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MGQLDGRVAVITGAGRGIGREHALLFAKEGASVVVNDLGGANDGSGSDAGPAQEVVDEITAAGGKAVANT DNISTWAGASNLVNQAVETFGQLDAVVNNAGILRDGFIAGLEEEQWDAVIQVHLKGHFAVLRHAAEYWKG QAKAGADIKATVVNTASDSGVTLPNPGQGNYGAAKAGIAALSCVAAAELERYGVKVNAIAPVARTRLTLA TPGMGAIFAAPVEEGAFDMFSPANISPLVAYLSTEKNPWTGQVFKVTGGSIQRLKGWSVTDTAETDGPWS IDLVRDSIEPWK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0380 | - | - | 100% (292) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2948c | - | e-115 | 72.40% (279) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0608 | - | 6e-82 | 56.38% (282) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3578c | - | 4e-77 | 56.78% (273) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1492 | - | 8e-74 | 52.30% (283) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3548c | - | 6e-77 | 56.78% (273) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 2e-21 | 29.77% (262) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. marinum M | MMAR_5036 | - | 2e-77 | 54.80% (281) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0612 | - | 1e-76 | 54.06% (283) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5999 | - | 2e-76 | 53.71% (283) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3887 | - | 7e-78 | 54.77% (283) | PUTATIVE short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4110 | - | 6e-77 | 54.45% (281) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2341 | - | 1e-113 | 70.21% (282) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0380|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_2341|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1492|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_5999|M.smegmatis_MC2_155 --------------------------------------------------
TH_3887|M.thermoresistible__bu --------------------------------------------------
MAV_0612|M.avium_104 --------------------------------------------------
Mb3578c|M.bovis_AF2122/97 --------------------------------------------------
Rv3548c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5036|M.marinum_M --------------------------------------------------
MUL_4110|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MAB_0380|M.abscessus_ATCC_1997 ------------------------MG----------QLDGRVAVITGAGR
Mvan_2341|M.vanbaalenii_PYR-1 -----------------------MMG----------MLDGRVAVITGAGR
Mflv_1492|M.gilvum_PYR-GCK ------------------------MG----------LLDGRVVIVTGAGG
MSMEG_5999|M.smegmatis_MC2_155 ------------------------MG----------LLDGRVVIVTGAGG
TH_3887|M.thermoresistible__bu ------------------------MG----------IVDGRVVIVTGAGN
MAV_0612|M.avium_104 ------------------------MG----------VVDGRVVIVTGAGG
Mb3578c|M.bovis_AF2122/97 ------------------------MG----------LVDGRVVIVTGAGG
Rv3548c|M.tuberculosis_H37Rv ------------------------MG----------LVDGRVVIVTGAGG
MMAR_5036|M.marinum_M ------------------------MG----------LLDGRVVIVTGAGG
MUL_4110|M.ulcerans_Agy99 ------------------------MG----------LLDGRVVIVTGAGG
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
:* .*. ..
MAB_0380|M.abscessus_ATCC_1997 GIGREHALLFAKEGASVVVNDLGGANDGSGSDAG-PAQEVVDEITAAGGK
Mvan_2341|M.vanbaalenii_PYR-1 GIGREHALLFAAQGAAVVVNDLGGSNTGEGADAG-PAHEVVAEITANGGR
Mflv_1492|M.gilvum_PYR-GCK GIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAQTVVDEIIAAGGE
MSMEG_5999|M.smegmatis_MC2_155 GIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQTVVDEIVAAGGE
TH_3887|M.thermoresistible__bu GIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQAVVDEIKAAGGE
MAV_0612|M.avium_104 GIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQSVVDEITAAGGE
Mb3578c|M.bovis_AF2122/97 GIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQDVVDEILAAGGQ
Rv3548c|M.tuberculosis_H37Rv GIGRAHALAFAAEGARVVVNDIGVGLDGSPASGGSAAQDVVDEILAAGGQ
MMAR_5036|M.marinum_M GIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAHGVVDEITAAGGE
MUL_4110|M.ulcerans_Agy99 GIGRAHALAFAVEGARVVVNDIGVGLDGSPAGGGSAAHGVVDEITAAGGE
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
*: . .: : * . * :* . : *: .: : *.
MAB_0380|M.abscessus_ATCC_1997 AVANTD--NISTWAGASNLVNQAVETFGQLDAVVNNAGILRDGFIAGLEE
Mvan_2341|M.vanbaalenii_PYR-1 AVANTD--SVADWDGAKRVVQQAIDEFGRLDVLVNNAGILRDAFIAGMAE
Mflv_1492|M.gilvum_PYR-GCK AVTSGA--NVADWGQAEGLIQTAVDAFGGLDVLVNNAGIVRDRMFANTSE
MSMEG_5999|M.smegmatis_MC2_155 AVANGS--NVADWAQAESLVQTAVDTFGGLDVLVNNAGIVRDRMFANTSE
TH_3887|M.thermoresistible__bu AVANGS--NVADWAQAEELVKTAIDTYGGLDVLVNNAGIVRDRMIANTSE
MAV_0612|M.avium_104 AVADGS--NVADWDQAAGLIQTAVETFGGLDVLVNNAGIVRDRMIANTSE
Mb3578c|M.bovis_AF2122/97 AVADGS--DISDWDQAANLIQAAVETYGGVDVLVNNAGIVRDRMIANTSE
Rv3548c|M.tuberculosis_H37Rv AVADGS--DISDWDQAANLIQAAVETYGGVDVLVNNAGIVRDRMIANTSE
MMAR_5036|M.marinum_M AVANGS--DVSNWQQAADLISTAVDTFGGLDVLVNNAGIVRDRMMANTSE
MUL_4110|M.ulcerans_Agy99 AVANGS--DVSNWQQAADLISTAVDTFGGLDVLVNNAGIVRDRMMANTSE
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
: : .:: . .:.* : : : .. :
MAB_0380|M.abscessus_ATCC_1997 EQWDAVIQVHLKGHFAVLR-----HAAEYWKGQAKAGAD---IKATVVNT
Mvan_2341|M.vanbaalenii_PYR-1 DQWDAVINVHLKGHFAMLH-----HAAAYWKEQSKAGEQ---PTAAVINT
Mflv_1492|M.gilvum_PYR-GCK EEFDAVTAVHLKGHFATMR-----HAAAYWRAKSKAGDT---VDARIINT
MSMEG_5999|M.smegmatis_MC2_155 EEFDAVVAVHLKGHFATMK-----HAAAYWRAKSKAGET---VDARIINT
TH_3887|M.thermoresistible__bu EEFDAVVAVHLKGHFATTR-----HAAAYWRGLAKEGKA---VDARIINT
MAV_0612|M.avium_104 EEFDAVIAVHLKGHFATMR-----HAAAYWRGLSKAGKA---VDGRIINT
Mb3578c|M.bovis_AF2122/97 EEFDAVIAVHLKGHFATMR-----HAASHWRGLSKAGKAPKDIDARIINT
Rv3548c|M.tuberculosis_H37Rv EEFDAVIAVHLKGHFATMR-----HAASHWRGLSKAGKAPKDIDARIINT
MMAR_5036|M.marinum_M EEFDAVIAVHLKGHFATMR-----HAASYWRGLSKAGKA---VDARIINT
MUL_4110|M.ulcerans_Agy99 EEFDAVIAVHLKGHFATMR-----HAASYWRGLSKVGKA---VDARIINT
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGAR--VVAIDVESA
. : *:.:.* .* . :: * : .:
MAB_0380|M.abscessus_ATCC_1997 ASDSGVTLPNPGQGNYGAAKAGIAALSCVAAAELERYGVKVNAIAPVART
Mvan_2341|M.vanbaalenii_PYR-1 ASGSGVTLPNAGQANYGAAKAGIAALTLIAAEELERYGVRVNAIAPIART
Mflv_1492|M.gilvum_PYR-GCK SSGAGLQG-SVGQANYSAAKAGIAALTLVAAAEMGRYGVSVNAIAPSART
MSMEG_5999|M.smegmatis_MC2_155 SSGAGLQG-SVGQANYSAAKAGIAALTLVAAAEMGRYGVTVNAIAPSART
TH_3887|M.thermoresistible__bu SSGAGLQG-SVGQGNYSAAKAGIAALTLVAAAELGRYGVTVNAIAPSART
MAV_0612|M.avium_104 SSGAGLQG-SVGQGNYSAAKAGIATLTLVGAAEMGRYGVTVNAIAPSART
Mb3578c|M.bovis_AF2122/97 SSGAGLQG-SVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAART
Rv3548c|M.tuberculosis_H37Rv SSGAGLQG-SVGQGNYSAAKAGIAALTLVGAAEMRRYGVTVNAIAPAART
MMAR_5036|M.marinum_M SSGAGLQG-SVGQANYSAAKAGIAALTLVGAAEMGRYGVTVNAIAPAART
MUL_4110|M.ulcerans_Agy99 SSGAGLQG-SVGQANYSAAKAGIAALTLVGAAEMGRYGVTVNAIAPAART
MLBr_02565|M.leprae_Br4923 AEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGI
:. . * . . :. :: : * .: :. *
MAB_0380|M.abscessus_ATCC_1997 RLTLATPGMGAIFAAPVEEGAFDMFSPANISP---------------LVA
Mvan_2341|M.vanbaalenii_PYR-1 RLTLATPGMGALMAEP-DDGELDLFAPANISP---------------LVG
Mflv_1492|M.gilvum_PYR-GCK RMTETV--FADMMATQ--DKDFDAMAPENVSP---------------LVV
MSMEG_5999|M.smegmatis_MC2_155 RMTETV--FADMMATQ--DQEFDAMAPENISP---------------IVV
TH_3887|M.thermoresistible__bu RMTETV--FAEMMATQ--DQEFDSMAPENISP---------------LVV
MAV_0612|M.avium_104 RMTETV--FAEMMATQ--DQDFDAMAPENVSP---------------LVV
Mb3578c|M.bovis_AF2122/97 RMTETV--FAEVMAKP--QEGFDAMAPENVSP---------------LVV
Rv3548c|M.tuberculosis_H37Rv RMTETV--FAEMMAKP--QEGFDAMAPENVSP---------------LVV
MMAR_5036|M.marinum_M RMTETV--FAEMMAKP--DEGFDAMAPENVSP---------------LVV
MUL_4110|M.ulcerans_Agy99 RMTETV--FAEMMAKP--DEGFDAMAPENVSP---------------LVV
MLBr_02565|M.leprae_Br4923 TRDKLLANMDDCRWDA--VLEVNLLAPQRLTEGLVGNGSISKGGRVIVLS
: .: ::* .:: ::
MAB_0380|M.abscessus_ATCC_1997 YLSTEKN-PWTGQVFKVTGGSIQRLKGWSVTDTAETDGPWS--------I
Mvan_2341|M.vanbaalenii_PYR-1 YLASEKC-PVTGKVYAVQGGAISLLQGWQDVETIETDKVWE--------L
Mflv_1492|M.gilvum_PYR-GCK WLGSVESRDVTGKMFEVEGGKIRVAEGWAHGPEIDKGARWDPAELGPVVG
MSMEG_5999|M.smegmatis_MC2_155 WLGSAEARDVTGKMFEVEGGKIRIAEGWAHGPEIDKGARWDPAELGPVVA
TH_3887|M.thermoresistible__bu WLGSAESKDVSGRVFEVEGGKVRVAEGWAHGPEADKGARWDPAELGPVVR
MAV_0612|M.avium_104 WLGSAEARDVTGKVFEVEGGKIRVAEGWAHGPQIDKGARWDPAELGPVVA
Mb3578c|M.bovis_AF2122/97 WLGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVS
Rv3548c|M.tuberculosis_H37Rv WLGSAESRDVTGKVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVS
MMAR_5036|M.marinum_M WLASAEAGAVTGKVFEVEGGVIRVAEGWAHGPEVDKGAKWDPAELRLVVA
MUL_4110|M.ulcerans_Agy99 WLASAEAGAVTGKVFEVEGGVIRVAEGWAHGPEVDKGAKWDPAELRLVVA
MLBr_02565|M.leprae_Br4923 SMAGIAGNRGQTNYATAKAGVIGLTQALAPG-LAEKGITINAVAPGFIET
:. . . .* : :. :.. .
MAB_0380|M.abscessus_ATCC_1997 DLVRDSIEPWK---------------------------------------
Mvan_2341|M.vanbaalenii_PYR-1 DDIAARLPGA----------------------------------------
Mflv_1492|M.gilvum_PYR-GCK DLLAKARTPVPVYGA-----------------------------------
MSMEG_5999|M.smegmatis_MC2_155 DLLAKARPAVPVYGA-----------------------------------
TH_3887|M.thermoresistible__bu DLLAKARQPVPVYGAXXAPPSTACSRSTSALSLRQLVANV----------
MAV_0612|M.avium_104 DLLGKARPPVPVYGA-----------------------------------
Mb3578c|M.bovis_AF2122/97 DLLAKSRPPVPVYGA-----------------------------------
Rv3548c|M.tuberculosis_H37Rv DLLAKSRPPVPVYGA-----------------------------------
MMAR_5036|M.marinum_M DLLAKSRPSVPVYGA-----------------------------------
MUL_4110|M.ulcerans_Agy99 DLLAKSRPSVPVYGA-----------------------------------
MLBr_02565|M.leprae_Br4923 QMTAAIPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIR
:
MAB_0380|M.abscessus_ATCC_1997 ---------
Mvan_2341|M.vanbaalenii_PYR-1 ---------
Mflv_1492|M.gilvum_PYR-GCK ---------
MSMEG_5999|M.smegmatis_MC2_155 ---------
TH_3887|M.thermoresistible__bu ---------
MAV_0612|M.avium_104 ---------
Mb3578c|M.bovis_AF2122/97 ---------
Rv3548c|M.tuberculosis_H37Rv ---------
MMAR_5036|M.marinum_M ---------
MUL_4110|M.ulcerans_Agy99 ---------
MLBr_02565|M.leprae_Br4923 VCGQAMLGA