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MSDLLGRVLAGGAGPFALLYRPESGAPDTVDVVSGAVTAVERIADLPLRDAHPGHDLLALVPYRQIVERG FVAPDDGAPLLALVIEEQESAALSDVLDRISEHPVVVGHSDFDIDDEEYARLASGIISEEIGQGAGANFV LKRNLLVQLHDYSIDTALTLFRRLLERERGAYWTFLVSTGNQVFIGATPERHISVQDSLAVMNPISGTYR YDANGPSLDAVMEFLADTKESDELYMVVDEELKMMARICPEGGQVQGPYLKEMARLAHTEYLISGVTDRD PREILAETMFAPTVTGSPLENACRVIQRYEPKGRRYYSGVAALISADSAGVRQLDSAILIRTAEISADGA LTAGTGATIVRHSNPASEAAETRSKAAGLLSALTTRRELRSHPRVTEALASRNTGIGSFWLGHGSGESAA NLAGRTALVIDAEDTFTSMIGLQLRALGLRVDIRRFDEEIHPGSHDFLVLGPGPGDPTAIDMPKIAALTA LTKAALTQRVPFLSICLSHQVLCRQLGLPIRRKEQPNQGVQRQIDLFGTERHVGFYNTFAAVTGSEWLDT PAGRVQISSDAVTGEVHALRAKRFASIQFHAESILTRDGVGIFAELLTPLATGVPVLA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0298 | - | - | 100% (618) | putative phenazine biosynthesis protein PhzE |
| M. abscessus ATCC 19977 | MAB_2647c | - | 8e-16 | 30.45% (220) | anthranilate synthase component I |
| M. abscessus ATCC 19977 | MAB_3535 | - | 7e-11 | 27.52% (258) | isochorismate synthase EntC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1635 | trpE | 1e-15 | 31.13% (212) | anthranilate synthase component I |
| M. gilvum PYR-GCK | Mflv_3602 | - | 3e-16 | 31.28% (211) | anthranilate synthase component I |
| M. tuberculosis H37Rv | Rv1609 | trpE | 1e-15 | 31.13% (212) | anthranilate synthase component I |
| M. leprae Br4923 | MLBr_01269 | trpE | 2e-15 | 30.37% (214) | anthranilate synthase component I |
| M. marinum M | MMAR_2411 | trpE | 1e-15 | 28.77% (285) | anthranilate synthase component I TrpE |
| M. avium 104 | MAV_3177 | trpE | 1e-15 | 27.62% (286) | anthranilate synthase component I |
| M. smegmatis MC2 155 | MSMEG_3217 | trpE | 2e-15 | 31.13% (212) | anthranilate synthase component I |
| M. thermoresistible (build 8) | TH_2725 | - | 2e-14 | 31.13% (212) | PUTATIVE anthranilate synthase component I |
| M. ulcerans Agy99 | MUL_1589 | trpE | 7e-16 | 28.77% (285) | anthranilate synthase component I |
| M. vanbaalenii PYR-1 | Mvan_2814 | - | 4e-15 | 31.28% (211) | anthranilate synthase component I |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3602|M.gilvum_PYR-GCK MQTTAD----------------LSVTTSREDFRTLAAEHRVVPVTRKVLA
Mvan_2814|M.vanbaalenii_PYR-1 MQMTAT----------------LSATTTREDFRALAAEHRVVPVTRKVLA
MSMEG_3217|M.smegmatis_MC2_155 MQTTANHSSRSTQTGTRAHGAALAETTSREDFRALATEHRVVPVIRKVLA
TH_2725|M.thermoresistible__bu --------------------------------------------------
MAV_3177|M.avium_104 MHAH------------------LAATTSREDFRQLAAEHRVVPVTRKVLA
Mb1635|M.bovis_AF2122/97 MHAD------------------LAATTSREDFRLLAAEHRVVPVTRKVLA
Rv1609|M.tuberculosis_H37Rv MHAD------------------LAATTSREDFRLLAAEHRVVPVTRKVLA
MMAR_2411|M.marinum_M MRAD------------------LATTITRENFRSLAAEHRVVPVTRKVLA
MUL_1589|M.ulcerans_Agy99 MRAD------------------LATTITRENFRSLAAERRVVPVTRKVLA
MLBr_01269|M.leprae_Br4923 MHAH------------------LAATTSREDFRQLAVDHRVVPVTRKVLA
MAB_0298|M.abscessus_ATCC_1997 MSDLLG----------------RVLAGGAGPFALLYRPESGAPDTVDVVS
Mflv_3602|M.gilvum_PYR-GCK DSETPLS--AYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPSALTVR
Mvan_2814|M.vanbaalenii_PYR-1 DSETPLS--AYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPSALTVR
MSMEG_3217|M.smegmatis_MC2_155 DSETPLS--AYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPSALTVR
TH_2725|M.thermoresistible__bu ------------------------------------------------VX
MAV_3177|M.avium_104 DSETPLS--AYRKLAANRPGTFLLESAEHGRSWSRWSFIGAGSPSALTVR
Mb1635|M.bovis_AF2122/97 DSETPLS--AYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVR
Rv1609|M.tuberculosis_H37Rv DSETPLS--AYRKLAANRPGTFLLESAENGRSWSRWSFIGAGAPTALTVR
MMAR_2411|M.marinum_M DSETPLS--AYRKLADGRPGTFLLESAENGRSWSRWSFIGAGAPTALTVR
MUL_1589|M.ulcerans_Agy99 DSETPLS--AYRKLADGRPGTFLLESAENGRSWSRWSFIGAGAPTALTVR
MLBr_01269|M.leprae_Br4923 DSETPLS--AYRKLAANRPSTFLLESAENGRSWSQWSFIGVGAPSALTIR
MAB_0298|M.abscessus_ATCC_1997 GAVTAVERIADLPLRDAHPGHDLLALVPYRQIVERGFVAPDDGAPLLALV
:
Mflv_3602|M.gilvum_PYR-GCK DGEAVWLGVIPQDAPAGGDPLQALRTTLTLLETA---ALPGLPPLSSG--
Mvan_2814|M.vanbaalenii_PYR-1 DGEAVWLGVIPQDAPSGGDPLQALRATLTLLETA---PLPGLPPLSSG--
MSMEG_3217|M.smegmatis_MC2_155 DNAAAWLGTAPEGAPSGGDPLDALRATLDLLKTE---AMAGLPPLSSG--
TH_2725|M.thermoresistible__bu X--------------------XALRATLELLKTE---PLPGLPPLSSG--
MAV_3177|M.avium_104 DGEAGWLGVVPQDAPTGGDPLQALRATLDLLATG---PLSGLPPLSGG--
Mb1635|M.bovis_AF2122/97 EGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADRQSEPGLPPLSGG--
Rv1609|M.tuberculosis_H37Rv EGQAVWLGAVPKDAPTGGDPLRALQVTLELLATADRQSEPGLPPLSGG--
MMAR_2411|M.marinum_M DGEAVWLGTAPEGAPTGGDPLRALQSTLEVLATG---VMPGLPPLSGG--
MUL_1589|M.ulcerans_Agy99 DGEAVWLGTAPEGAPTGGDPLRALQSTLEVLATG---VMPGLPPLSGG--
MLBr_01269|M.leprae_Br4923 DGEAVWLGTVPQDAPTGGDPLHVLQATLELLATA---AMPGLPPLSSG--
MAB_0298|M.abscessus_ATCC_1997 IEEQESAALSDVLDRISEHPVVVGHSDFDIDDEEYARLASGIISEEIGQG
. : : : .*: . . *
Mflv_3602|M.gilvum_PYR-GCK -----------LVGFFAYDLVRRLERLPELTVDDLGLPDMMLLLATDIAA
Mvan_2814|M.vanbaalenii_PYR-1 -----------LVGFFAYDLVRRLERLPELTVDDLALPDMMLLLATDVAA
MSMEG_3217|M.smegmatis_MC2_155 -----------LVGFFAYDMVRRLERLPELAVDDLGLPDMLLLLATDIAA
TH_2725|M.thermoresistible__bu -----------LVGFFAYDLVRRLERLPELAVDDLGLPDMVLLLATDIAA
MAV_3177|M.avium_104 -----------MVGFFAYDLVRRLERLPELAVDDLGLPDMLLLLATDLAA
Mb1635|M.bovis_AF2122/97 -----------MVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLATDVAA
Rv1609|M.tuberculosis_H37Rv -----------MVGFFAYDMVRRLERLPERAVDDLCLPDMLLLLATDVAA
MMAR_2411|M.marinum_M -----------MVGFFAYDMVRRLERLPNLAVDDLQLPEMLLLLATDLAA
MUL_1589|M.ulcerans_Agy99 -----------MVGFFAYDMVRRLERLPNLAVDDLHLPEMLLLLATDLAA
MLBr_01269|M.leprae_Br4923 -----------MVGFFAYDMVRRLERLPELALNDLQLPDMLLLLATDVAA
MAB_0298|M.abscessus_ATCC_1997 AGANFVLKRNLLVQLHDYSIDTALTLFRRLLERERGAYWTFLVSTGNQVF
:* :. *.: * : . : .*: : : .
Mflv_3602|M.gilvum_PYR-GCK VDHHEGTITLIANAVNWNGTDERVDEAYDDAVARLDVMTAALAEPLASTV
Mvan_2814|M.vanbaalenii_PYR-1 VDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALAEPLASTV
MSMEG_3217|M.smegmatis_MC2_155 VDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTKALGQPLTSAV
TH_2725|M.thermoresistible__bu VDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGEPLPSAV
MAV_3177|M.avium_104 VDHHEGTITLIANAVNWNGTDERVDEAYDDAVARLDVMTAALGQPLASTV
Mb1635|M.bovis_AF2122/97 VDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTV
Rv1609|M.tuberculosis_H37Rv VDHHEGTITLIANAVNWNGTDERVDWAYDDAVARLDVMTAALGQPLPSTV
MMAR_2411|M.marinum_M VDHHEGTITLIANAVNWDGTDERVDWAYDDAIARLDVMTAALSQPLPSSV
MUL_1589|M.ulcerans_Agy99 VDHHEGTITLIANAVNWDGTDERVDWAYDDAIARLDVMTAALSQPLPSSV
MLBr_01269|M.leprae_Br4923 VDHHEGTITLIANAVNWNGTDERVDQAYDDAIARLDVMTAALGQPLPSTI
MAB_0298|M.abscessus_ATCC_1997 IGATPERHISVQDSLAVMNPIS-GTYRYDANGPSLDAVMEFLADTKESDE
:. : ::: .. . ** . **.: *.:. *
Mflv_3602|M.gilvum_PYR-GCK ATFRRPAPQPRAQLSVDEYT-------------AIVDKLVGDIEAGEAFQ
Mvan_2814|M.vanbaalenii_PYR-1 ATFSRPVPEHRSQRTVEEYT-------------AIVDKLVGDIEAGEAFQ
MSMEG_3217|M.smegmatis_MC2_155 ATFSRPAPDHRAQRTMEEYT-------------EIVDKLVGDIEAGEAFQ
TH_2725|M.thermoresistible__bu ATFSRPEPRYRAQRTVEEYT-------------AIVEKLVGDIEAGEAFQ
MAV_3177|M.avium_104 ATFERPEPRYRAQRSVEEYG-------------KIVDYLVEQIAAGEAFQ
Mb1635|M.bovis_AF2122/97 ATFSRPEPRHRAQRTVEEYG-------------AIVEYLVDQIAAGEAFQ
Rv1609|M.tuberculosis_H37Rv ATFSRPEPRHRAQRTVEEYG-------------AIVEYLVDQIAAGEAFQ
MMAR_2411|M.marinum_M ATFSRPEPHYRAQRTVEEYG-------------AIVEHLVEEIAAGEAFQ
MUL_1589|M.ulcerans_Agy99 ATFSRPEPHYRAQRTVEEYG-------------AIVEHLVEEIAAGEAFQ
MLBr_01269|M.leprae_Br4923 ATFSRPDPRRRAQCTIEEYG-------------AIVDHLVDQIAAGEAFQ
MAB_0298|M.abscessus_ATCC_1997 LYMVVDEELKMMARICPEGGQVQGPYLKEMARLAHTEYLISGVTDRDPRE
: * .: *: : :. :
Mflv_3602|M.gilvum_PYR-GCK VVPSQRFEMDTAADPLD-VYRMLRVTNPSPYMYLLNVP-----------D
Mvan_2814|M.vanbaalenii_PYR-1 VVPSQRFEMDTDADPLD-VYRMLRVTNPSPYMYLLNVP-----------N
MSMEG_3217|M.smegmatis_MC2_155 VVPSQRFEMDTAADPLD-VYRILRVTNPSPYMYLLNIP-----------D
TH_2725|M.thermoresistible__bu VVPSQRFEMDTDADPLD-VYRMLRVSNPSPYMYLLHVP-----------D
MAV_3177|M.avium_104 VVPSQRFEMDTDVDPID-VYRMLRVTNPSPYMYLLHVP-----------N
Mb1635|M.bovis_AF2122/97 VVPSQRFEMDTDVDPID-VYRILRVTNPSPYMYLLQVP-----------N
Rv1609|M.tuberculosis_H37Rv VVPSQRFEMDTDVDPID-VYRILRVTNPSPYMYLLQVP-----------N
MMAR_2411|M.marinum_M VVPSQRFEMDTTVDPID-VYRILRVTNPSPYMYLIQVP-----------N
MUL_1589|M.ulcerans_Agy99 VVPSQRFEMDTTVDPID-VYRILRVTNPSPYMYLIQVP-----------N
MLBr_01269|M.leprae_Br4923 VVPSQRFEVDTDVDPID-VYRMLRVTNPSPYMYLLHVP-----------N
MAB_0298|M.abscessus_ATCC_1997 ILAETMFAPTVTGSPLENACRVIQRYEPKGRRYYSGVAALISADSAGVRQ
::.. * . .*:: . *::: :*. * :. :
Mflv_3602|M.gilvum_PYR-GCK HDGGLDFSIVGSSPEALVTVKDGRATTHPIAGTRWRGDTEEEDILLEKEL
Mvan_2814|M.vanbaalenii_PYR-1 ADGGLDFSIVGSSPEALVTVKDGRATTHPIAGTRWRGDTEEEDLLLEKEL
MSMEG_3217|M.smegmatis_MC2_155 ADGGLDFSIVGSSPEALVTVKDGRATTHPIAGTRWRGATEEEDVLLEKEL
TH_2725|M.thermoresistible__bu DAGGLDFSIVGSSPEALVTVKDGRATTHPIAGTRWRGATEEEDVLLEKEL
MAV_3177|M.avium_104 DAGGTDFSIVGSSPEALVTVADGVATTHPIAGTRWRGQTDEEDQLLEKEL
Mb1635|M.bovis_AF2122/97 SDGAVDFSIVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEKEL
Rv1609|M.tuberculosis_H37Rv SDGAVDFSIVGSSPEALVTVHEGWATTHPIAGTRWRGRTDDEDVLLEKEL
MMAR_2411|M.marinum_M DHGSVEFSIVGSSPEALVTVHDGCATTHPIAGTRWRGETDEEDQLLEKEL
MUL_1589|M.ulcerans_Agy99 DHGSVEFSIVGSSPEALVTVHDGCATTHPIAGTRWRGETDEEDQLLEKEL
MLBr_01269|M.leprae_Br4923 SDGATGFSIVGSSPEALVTVKDGRVTTHPIAGTRWRGQTEEEDQLLEKEL
MAB_0298|M.abscessus_ATCC_1997 LDSAILIRTAEISADGALTAGTGATIVRHSNPASEAAETRSKAAGLLSAL
.. : . *.:. :*. * . .: : . * .: * . *
Mflv_3602|M.gilvum_PYR-GCK LSDEKERAEHLMLVDLGRN--DLGRVCRPGTVKVEDYSHIERYSHVMHLV
Mvan_2814|M.vanbaalenii_PYR-1 LCDEKERAEHLMLVDLGRN--DLGRVCRPGTVKVEDYSHIERYSHVMHLV
MSMEG_3217|M.smegmatis_MC2_155 LADEKERAEHLMLVDLGRN--DLGRVCRPGTVRVDDYSHIERYSHVMHLV
TH_2725|M.thermoresistible__bu LADEKERAEHLMLVDLGRN--DLGRVCRPGTVRVEDYSHIERYSHVMHLV
MAV_3177|M.avium_104 LADEKERAEHLMLVDLGRN--DLGRVCAPGTVRVDDYSHIERYSHVMHLV
Mb1635|M.bovis_AF2122/97 LADDKERAEHLMLVDLGRN--DLGRVCTPGTVRVEDYSHIERYSHVMHLV
Rv1609|M.tuberculosis_H37Rv LADDKERAEHLMLVDLGRN--DLGRVCTPGTVRVEDYSHIERYSHVMHLV
MMAR_2411|M.marinum_M LADQKELAEHLMLVDLGRN--DLGRVCIPGTVRVEDYSHIERYSHVMHLV
MUL_1589|M.ulcerans_Agy99 LADQKELAEHLMLVDLGRN--DLGRVCIPGTVRVEDYSHIERYSHVMHLV
MLBr_01269|M.leprae_Br4923 LADEKERAEHLMLVDLGRN--DLGRVCTPGTVRVEDYSHVERYSHVMHMV
MAB_0298|M.abscessus_ATCC_1997 TTRRELRSHPRVTEALASRNTGIGSFWLGHGSGESAANLAGRTALVIDAE
: :. : *. . .:* . . . * : *:.
Mflv_3602|M.gilvum_PYR-GCK STVTGLLADGRSAL--------------DAVTACFPAGTLSG------AP
Mvan_2814|M.vanbaalenii_PYR-1 STVTGLLADGKTAL--------------DAVTACFPAGTLSG------AP
MSMEG_3217|M.smegmatis_MC2_155 STVTGELAEDKTAL--------------DAVTACFPAGTLSG------AP
TH_2725|M.thermoresistible__bu STVTGELAEGKTAL--------------DPITACFPAGTLSG------AP
MAV_3177|M.avium_104 STVTGVLDAGRTAL--------------DAVTACFPAGTLSG------AP
Mb1635|M.bovis_AF2122/97 STVTGKLGEGRTAL--------------DAVTACFPAGTLSG------AP
Rv1609|M.tuberculosis_H37Rv STVTGKLGEGRTAL--------------DAVTACFPAGTLSG------AP
MMAR_2411|M.marinum_M STVTGLLDAGHSAL--------------DAVTACFPAGTLSG------AP
MUL_1589|M.ulcerans_Agy99 STVTGLLDAGHSAL--------------DAVTACFPAGTLSG------AP
MLBr_01269|M.leprae_Br4923 STVTGLLGEGRTAL--------------DAVTACFPAGTLSG------AP
MAB_0298|M.abscessus_ATCC_1997 DTFTSMIGLQLRALGLRVDIRRFDEEIHPGSHDFLVLGPGPGDPTAIDMP
.*.*. : ** : *. .* *
Mflv_3602|M.gilvum_PYR-GCK KVRAMELIEEVEKTRRGLYG-------------------------GVLGY
Mvan_2814|M.vanbaalenii_PYR-1 KVRAMELIEEVEKTRRGLYG-------------------------GVLGY
MSMEG_3217|M.smegmatis_MC2_155 KVRAMELIEEVEKTRRGLYG-------------------------GVVGY
TH_2725|M.thermoresistible__bu KVRAMELIEEVEKTRRGLYG-------------------------GVLGY
MAV_3177|M.avium_104 KVRAMELIEEVEKTRRGLYG-------------------------GVVGY
Mb1635|M.bovis_AF2122/97 KVRAMELIEEVEKTRRGLYG-------------------------GVVGY
Rv1609|M.tuberculosis_H37Rv KVRAMELIEEVEKTRRGLYG-------------------------GVVGY
MMAR_2411|M.marinum_M KVRAMELIEEMEKTRRGLYG-------------------------GVVGY
MUL_1589|M.ulcerans_Agy99 KVRAMELIEEMEKTRRGLYG-------------------------GVVGY
MLBr_01269|M.leprae_Br4923 KVRSMELIEEVEKTRRGLYG-------------------------GVVGY
MAB_0298|M.abscessus_ATCC_1997 KIAALTALTKAALTQRVPFLSICLSHQVLCRQLGLPIRRKEQPNQGVQRQ
*: :: : : *:* : **
Mflv_3602|M.gilvum_PYR-GCK LDFAGNADFAIAIRTALMRDGTAYVQAGGGVVADSNGPYEYNESANKARA
Mvan_2814|M.vanbaalenii_PYR-1 LDFAGNADFAIAIRTALIRNGTAYVQAGGGVVADSNGPYEYNEASNKARA
MSMEG_3217|M.smegmatis_MC2_155 LDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADSNGPYEYTEAANKARA
TH_2725|M.thermoresistible__bu LDFAGNADFAIAIRTALIRNGTAYVQSGGGVVADSNGPYEYNEAANKARA
MAV_3177|M.avium_104 LDFAGNADFAIAIRTALMRGGTAYVQSGGGVVADSNGPYEYTEATNKARA
Mb1635|M.bovis_AF2122/97 LDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARA
Rv1609|M.tuberculosis_H37Rv LDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADSNGSYEYNEARNKARA
MMAR_2411|M.marinum_M LDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADSNGPYEYNEARNKARA
MUL_1589|M.ulcerans_Agy99 LDFAGNADFAIAIRTALMRNGTAYVQAGGGVVADSNGPYEYNEARNKARA
MLBr_01269|M.leprae_Br4923 LDFAGNADFAIAIRTALMRDGIAYVQAGGGVVADSNGPYEYIEASNKARA
MAB_0298|M.abscessus_ATCC_1997 IDLFGTERHVGFYNTFAAVTGSEWLDTPAGRVQISSDAVTGEVHALRAKR
:*: *. .. .* * :::: .* * *... :*:
Mflv_3602|M.gilvum_PYR-GCK VLAAIAAAETLSEP-----------------------
Mvan_2814|M.vanbaalenii_PYR-1 VLAAIAAAETLSEP-----------------------
MSMEG_3217|M.smegmatis_MC2_155 VLNAIAAAATLAEP-----------------------
TH_2725|M.thermoresistible__bu VLHAIAAAETLSEP-----------------------
MAV_3177|M.avium_104 VLGAIAAAETLTEPGARR-------------------
Mb1635|M.bovis_AF2122/97 VLNAIAAAETLAAPGANRSGC----------------
Rv1609|M.tuberculosis_H37Rv VLNAIAAAETLAAPGANRSGC----------------
MMAR_2411|M.marinum_M VLNAIAAAETLARPDAACSD-----------------
MUL_1589|M.ulcerans_Agy99 VLNAIAAAETLARPDAACSD-----------------
MLBr_01269|M.leprae_Br4923 VLNAIAAAETLTSLDFGVALAPGRVAARGEAGNQGRL
MAB_0298|M.abscessus_ATCC_1997 FASIQFHAESILTRDGVGIFAELLTPLATGVPVLA--
. * ::