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PVAVVTGAGSGIGRATAERFGRKGWTIVVSDINEATGAETVDRITRTGGSAVFRRLDVADLEDWRQFTDW VCEEHGTPDLLVNNAGILIAGGFLEQTGADWRRMIAINMMSPLVGSRLFVQRMVEAGARGHIANICSVGA FMPTPLAPSYVVAKQGAWFGTQALRAEFGKRGIGVSAICPGLIDTNLSANGTRSGVDETAGSSWTDKLNR GQHFFGRSPDHVAEAVERSMRWNLSTVPVGFEAWIGWFLYRLSPGLMRGALGIAQMSLAERAVDVSSRAL TALGIGGKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0144c | - | - | 100% (290) | putative oxidoreductase EphD |
| M. abscessus ATCC 19977 | MAB_0143c | - | 5e-64 | 45.39% (271) | putative oxidoreductase EphD |
| M. abscessus ATCC 19977 | MAB_4022c | - | 8e-60 | 44.57% (276) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 2e-43 | 39.06% (256) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 9e-38 | 35.23% (264) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 2e-43 | 39.06% (256) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 7e-41 | 37.12% (264) | short chain dehydrogenase |
| M. marinum M | MMAR_3259 | ephD | 3e-41 | 39.31% (262) | short-chain dehydrogenase EphD |
| M. avium 104 | MAV_2275 | - | 2e-43 | 39.77% (264) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 3e-42 | 40.15% (259) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 2e-40 | 35.38% (260) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 2e-41 | 39.31% (262) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 7e-39 | 35.52% (259) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
Rv2214c|M.tuberculosis_H37Rv MPATQ---QMSR-LVDSPDGVRIAVYHEGNPDGPTVVLVHGFPDSHVLWD
MMAR_3259|M.marinum_M MSATR---QAPQQFVDSAGGVRIAVYEEGNPDGPTVVLVHGFPDSHVLWD
MUL_3574|M.ulcerans_Agy99 MPATK---QAPQQFVDSAGGVRIAVYEEGNPDSPTVVLVHGFPDSHVLWD
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MAV_2275|M.avium_104 MPAPQ---HSPQHFVHSADGTRIAVYDEGNPEGPTVVLVHGFPDSHVLWD
TH_4323|M.thermoresistible__bu --------MATEHFIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWD
Mflv_2937|M.gilvum_PYR-GCK --------MSSQRFVVSRDGVRIAVYEEGAADGPTVVLVHGHADTHEAWD
Mvan_3576|M.vanbaalenii_PYR-1 --------MSTQRFVESSDGVRIAVSEQGNPDGPTLVLVHGLRDTHRVWD
MSMEG_4280|M.smegmatis_MC2_155 ----------MYTFVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWD
MAB_0144c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
Rv2214c|M.tuberculosis_H37Rv GVVPLLAERFRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGELSP
MMAR_3259|M.marinum_M GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MUL_3574|M.ulcerans_Agy99 GVVPRLAERFRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEALSP
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MAV_2275|M.avium_104 GVVPLLAERFRILRYDNRGVGASSAPKPVSAYRMDRFADDFAAVIGELSP
TH_4323|M.thermoresistible__bu SVAPLLADRFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDALAP
Mflv_2937|M.gilvum_PYR-GCK AVVALLAARFRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAAVLDAVSA
Mvan_3576|M.vanbaalenii_PYR-1 PVVALLADRFRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAAVAAAVGG
MSMEG_4280|M.smegmatis_MC2_155 GVVGELGDRYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSP
MAB_0144c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
Rv2214c|M.tuberculosis_H37Rv GEPVHVLAHDWGSVGVWEYLRRPGASDRVASFTSVSGPSQDHLVNYVYGG
MMAR_3259|M.marinum_M GQPVHVLGHDWGSVAIWEYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MUL_3574|M.ulcerans_Agy99 GQPVHVLGHDWGSVAIWDYLTRSGAADRVASFTSVSGPSQDQLVNYIFGG
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MAV_2275|M.avium_104 GGPVHVLAHDWGSVGVWHYLKRPGANDRVATFTSVSGPSQDQLVDYIFSG
TH_4323|M.thermoresistible__bu GQRVHVLAHDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDG
Mflv_2937|M.gilvum_PYR-GCK EAPVHVLAHDRGSAGVWRYLARPESRGRLASFTSVSGPAPEHVARYLRDT
Mvan_3576|M.vanbaalenii_PYR-1 DTPVHVLAHGWGAAGVWQYLKRADAPERVASLTSVSGPSPEHVAGYVRAA
MSMEG_4280|M.smegmatis_MC2_155 DAPVHVLAHDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRG
MAB_0144c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR-RNM
Rv2214c|M.tuberculosis_H37Rv LRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVR-RNM
MMAR_3259|M.marinum_M LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVR-RNM
MUL_3574|M.ulcerans_Agy99 LRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSRASVR-RNM
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIR-RTM
MAV_2275|M.avium_104 LRAPWRPRAFARALGQALRLSYMILLSIPVLAPLALRLTLSIPALR-RNA
TH_4323|M.thermoresistible__bu LAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRL
Mflv_2937|M.gilvum_PYR-GCK LARPQHPARFAGGLGHLAR--------------------LAAAAPR----
Mvan_3576|M.vanbaalenii_PYR-1 LTSPR---RFVRGAGQLVR--------------------LAAAAPR----
MSMEG_4280|M.smegmatis_MC2_155 LARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR---RGAARR---L
MAB_0144c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 VGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPV
Rv2214c|M.tuberculosis_H37Rv VGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPV
MMAR_3259|M.marinum_M VDNLPLDRIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPV
MUL_3574|M.ulcerans_Agy99 VDNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRGVPVIDVPV
MLBr_00862|M.leprae_Br4923 VDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPV
MAV_2275|M.avium_104 VDNIPIEQIHHSDRLAADAARSVKTYPANYFRSFAIRK--QGVAVIDVPV
TH_4323|M.thermoresistible__bu RDGVPADRLHHSDTFAADAARSIKVYGANFLRTL---RHARTDHFVRVPV
Mflv_2937|M.gilvum_PYR-GCK -------------------AVTDKTLRANLFPVS----SGGDAHDVDIPV
Mvan_3576|M.vanbaalenii_PYR-1 -------------------AATAKPYRANLRPAA----PAG--VPVDVPV
MSMEG_4280|M.smegmatis_MC2_155 QAIDTPGPKFQSENLDIDAANSLKIYRANAIRSFT---HVRRDHYVQVPV
MAB_0144c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 QLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
Rv2214c|M.tuberculosis_H37Rv QLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MMAR_3259|M.marinum_M QLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MUL_3574|M.ulcerans_Agy99 QLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MLBr_00862|M.leprae_Br4923 QLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVH
MAV_2275|M.avium_104 QLIVNTEDRYVRPYGYDHTPRFVPRLWRRDIRAGHFSPMSHPQVMAAAVH
TH_4323|M.thermoresistible__bu QLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVT
Mflv_2937|M.gilvum_PYR-GCK QLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVTPTSHPGILARALT
Mvan_3576|M.vanbaalenii_PYR-1 QLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLSPGSHPQVLARAVD
MSMEG_4280|M.smegmatis_MC2_155 QLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQAVG
MAB_0144c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 DFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFA
Rv2214c|M.tuberculosis_H37Rv DFADLADGKQPSRALLRAQVGRPRGYFGDTLVSVTGAGSGIGRETALAFA
MMAR_3259|M.marinum_M DFADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFA
MUL_3574|M.ulcerans_Agy99 DFADLVDGKPPSRALLRAQVGRPRKYFGDTLVAVTGAGSGIGRETALAFA
MLBr_00862|M.leprae_Br4923 DLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALA
MAV_2275|M.avium_104 DFADMAEGKPASRALLRAQVGRPRKAFGDTLVSVTGAGSGIGRATAFAFA
TH_4323|M.thermoresistible__bu ELADHLAGAPAGRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFA
Mflv_2937|M.gilvum_PYR-GCK QLVDHLDGAPAARELLRAQVGRPRKAFGDTLVAVTGAASGIGRATALAFA
Mvan_3576|M.vanbaalenii_PYR-1 QLVDHLGGAPAPRELLRAQVGRARKVFGDTLVSVTGAASGIGRETALAFA
MSMEG_4280|M.smegmatis_MC2_155 EFVDHMEGAPPARALRRAEVARPRKAFSDMLVSVTGAASGIGRATALEFA
MAB_0144c|M.abscessus_ATCC_199 ----------------------------MPVAVVTGAGSGIGRATAERFG
:. :***..**** ** :.
Mb2237c|M.bovis_AF2122/97 REGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERV
Rv2214c|M.tuberculosis_H37Rv REGAEIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERV
MMAR_3259|M.marinum_M REGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQV
MUL_3574|M.ulcerans_Agy99 REGAEVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSDTEAVEAFADQV
MLBr_00862|M.leprae_Br4923 RRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQV
MAV_2275|M.avium_104 REGAELIVSDIDEAAVKATAAEIAGRGGVAHAYVLDVSDAQAVEEFAERV
TH_4323|M.thermoresistible__bu REGAEVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRFADEV
Mflv_2937|M.gilvum_PYR-GCK HHGADVVISDVNAAGLDETARLVTSAGVHAYPYTVDVADAAAVEAFAEQV
Mvan_3576|M.vanbaalenii_PYR-1 RAGADVVISDVDEAGLEQTARLVTAAGAAAHSYTVDVADAAAVEAMAELV
MSMEG_4280|M.smegmatis_MC2_155 RLGAEIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVADPDAVQRFVDDV
MAB_0144c|M.abscessus_ATCC_199 RKGWTIVVSDINEATGAETVDRITRTGGSAVFRRLDVADLEDWRQFTDWV
: * :::**:: * *. : * * :**:* :.: *
Mb2237c|M.bovis_AF2122/97 SAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQ
Rv2214c|M.tuberculosis_H37Rv SAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQ
MMAR_3259|M.marinum_M SATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQ
MUL_3574|M.ulcerans_Agy99 SATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLGGVVNGCRAFGQ
MLBr_00862|M.leprae_Br4923 SAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQ
MAV_2275|M.avium_104 SAAHGVPDIVVNNAGIGQAGGFLDTPAEEFDRVLAVNLGGVVNGCRSFAR
TH_4323|M.thermoresistible__bu CARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVLEVNLGGVVNGCRAFAP
Mflv_2937|M.gilvum_PYR-GCK CAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVLDINFGGVVNGCRSFGK
Mvan_3576|M.vanbaalenii_PYR-1 CAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVLGINFGGVVNGCRSWGR
MSMEG_4280|M.smegmatis_MC2_155 CATHGVPDIVVNNAGIGHAGNFLDTPADQYERVLEVNFGGVVNCCRAFGR
MAB_0144c|M.abscessus_ATCC_199 CEEHGTPDLLVNNAGILIAGGFLEQTGADWRRMIAINMMSPLVGSRLFVQ
. ** **::*****: ** **: . :: *:: :*: . : .* :
Mb2237c|M.bovis_AF2122/97 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAA
Rv2214c|M.tuberculosis_H37Rv RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAA
MMAR_3259|M.marinum_M RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
MUL_3574|M.ulcerans_Agy99 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
MLBr_00862|M.leprae_Br4923 RLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAV
MAV_2275|M.avium_104 RMVQRGTGGHLVNVSSMAAYAPLQSLSAYCTSKAATFMFSDCLRAELDAA
TH_4323|M.thermoresistible__bu RLVERGTGGHIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRAELDSA
Mflv_2937|M.gilvum_PYR-GCK RLADRGVGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAELDSF
Mvan_3576|M.vanbaalenii_PYR-1 RLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAELDSA
MSMEG_4280|M.smegmatis_MC2_155 RLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKAAVFMFSDCLRAELAHA
MAB_0144c|M.abscessus_ATCC_199 RMVEAGARGHIANICSVGAFMPTPLAPSYVVAKQGAWFGTQALRAEFGKR
*:.: *. **:.*:.*:.:: * :* .:* ..:: ::.****:
Mb2237c|M.bovis_AF2122/97 GVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFALRSYG
Rv2214c|M.tuberculosis_H37Rv GVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQIDKMFALRSYG
MMAR_3259|M.marinum_M DVGLTTICPGVINTNIVNTTRFDAPPGKGGDQVDGRRGQIDKMFALRSYG
MUL_3574|M.ulcerans_Agy99 DVGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRGQIDKMFALRSYG
MLBr_00862|M.leprae_Br4923 GVGLTTICPGVIDTNIIQSTRIDTP-TAKQERVRDRRGQLDMMFRLRRYG
MAV_2275|M.avium_104 GVGLTTICPGLIDTNIINTTRFDAPAGARAERVDDRRGQLGKMFALRHYG
TH_4323|M.thermoresistible__bu GIMLTTICPSTVNTNIIGSTRFNAP-DGLDDVVDTRREQLQKLFALRRFG
Mflv_2937|M.gilvum_PYR-GCK GIGLTTICPGFISTNIVDTTRFSLA-QGRDDDVDVLRGRAQKGFSARKYG
Mvan_3576|M.vanbaalenii_PYR-1 GIGVTTICPGVIGTNIVDTTRFSLP-EARRDDAESIRRRARQGFAVRRVG
MSMEG_4280|M.smegmatis_MC2_155 GIGVTTLCPGMIDTGIVDTTRFDVP-AHKAGQVEARRAQVKKTFQARRYG
MAB_0144c|M.abscessus_ATCC_199 GIGVSAICPGLIDTNLSANGTRSGVDETAGSSWTDKLNRGQHFFGR---S
.: ::::**. :.*.: . : * .
Mb2237c|M.bovis_AF2122/97 PDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLRVI--
Rv2214c|M.tuberculosis_H37Rv PDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLPQALRSTARLRVI--
MMAR_3259|M.marinum_M PDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARMRVI--
MUL_3574|M.ulcerans_Agy99 PDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLPPALRSTARMRVI--
MLBr_00862|M.leprae_Br4923 PDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI--
MAV_2275|M.avium_104 PDKVADAILSSVQKKKPIRPVAPEAYALYGLSRVMPQGLRNAARLRVI--
TH_4323|M.thermoresistible__bu PDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLPQALRSTARGRVL--
Mflv_2937|M.gilvum_PYR-GCK PEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHALPQVLRSTARGGNFV-
Mvan_3576|M.vanbaalenii_PYR-1 PDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHALPQAMRSAARGGNIM-
MSMEG_4280|M.smegmatis_MC2_155 PEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFPAALRRAARSQVL--
MAB_0144c|M.abscessus_ATCC_199 PDHVAEAVERSMRWNLSTVPVGFEAWIGWFLYRLSPGLMRGALGIAQMSL
*::.*.:: :: : . ** ** : : : * :* : :
Mb2237c|M.bovis_AF2122/97 ---------------------
Rv2214c|M.tuberculosis_H37Rv ---------------------
MMAR_3259|M.marinum_M ---------------------
MUL_3574|M.ulcerans_Agy99 ---------------------
MLBr_00862|M.leprae_Br4923 ---------------------
MAV_2275|M.avium_104 ---------------------
TH_4323|M.thermoresistible__bu ---------------------
Mflv_2937|M.gilvum_PYR-GCK ---------------------
Mvan_3576|M.vanbaalenii_PYR-1 ---------------------
MSMEG_4280|M.smegmatis_MC2_155 ---------------------
MAB_0144c|M.abscessus_ATCC_199 AERAVDVSSRALTALGIGGKR