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RVNPSEPRLVVVTGAGSGIGRATAIRFAKRGAHVVVTDLDLDTANETVDLILAMGRNASAVQLDVTDPAH WADVARYVSIEYGVPDVLVNNAGIALGGPFLKLTPADWDRLLSVNLMGVVHGCRVFGEQMVERGSGHIVN IASAAAFTPTAVMAPYSVSKAGVKMLTECLRLELGPKGVGVSAICPGFINTNIGVHGTMVGVDPEIADAS QRRIQRIREFTEKLPWTPMSPELVARAVTRAIRLDLVVVPVKLESWFGYFVSRALPAVNRRLMAPFGVDR FERLGARALVKQQEHYVPALVESVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4023c | - | - | 100% (306) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4022c | - | e-120 | 73.63% (292) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0514 | - | 1e-80 | 56.73% (275) | oxidoreductase EphD |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 3e-52 | 43.82% (267) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 4e-51 | 44.32% (264) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 3e-52 | 43.82% (267) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 5e-53 | 45.08% (264) | short chain dehydrogenase |
| M. marinum M | MMAR_1932 | ephD_1 | 1e-57 | 44.96% (278) | short-chain dehydrogenase EphD_1 |
| M. avium 104 | MAV_3670 | - | 9e-57 | 44.07% (270) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 4e-50 | 45.28% (265) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 3e-52 | 43.35% (263) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3574 | ephD | 4e-50 | 42.59% (263) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 3e-50 | 42.59% (263) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 MPATQ---QMSR-LVDSPDGVRIAVYHEG--NPDGPTVVLVHGFPDSHVL
Rv2214c|M.tuberculosis_H37Rv MPATQ---QMSR-LVDSPDGVRIAVYHEG--NPDGPTVVLVHGFPDSHVL
MUL_3574|M.ulcerans_Agy99 MPATK---QAPQQFVDSAGGVRIAVYEEG--NPDSPTVVLVHGFPDSHVL
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSG--QPEGPAIVLVHGFPDSHVL
TH_4323|M.thermoresistible__bu --------MATEHFIDSSGGVRIAAYEEG--NPDGPTVVLVHGWPDSHVV
Mflv_2937|M.gilvum_PYR-GCK --------MSSQRFVVSRDGVRIAVYEEG--AADGPTVVLVHGHADTHEA
Mvan_3576|M.vanbaalenii_PYR-1 --------MSTQRFVESSDGVRIAVSEQG--NPDGPTLVLVHGLRDTHRV
MSMEG_4280|M.smegmatis_MC2_155 ----------MYTFVTSQDGTRIAVYQQG--DPERPTLVMAHGWPDSHVL
MMAR_1932|M.marinum_M ------MNTASRTGITASDGATLAVYHYTPLDPQRPTILAIHGWPDNHHL
MAV_3670|M.avium_104 ------MTVTS--TITADDGVTLAVHRYTDIDPARPTILAIHGFPDNHHV
MAB_4023c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 WDGVVPLLAER-FRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGE
Rv2214c|M.tuberculosis_H37Rv WDGVVPLLAER-FRIVRYDNRGVGRSSVPKPISAYTMAHFADDFDAVIGE
MUL_3574|M.ulcerans_Agy99 WDGVVPRLAER-FRILRYDNRGVGLSSAPKAVSAYTTACLADDFAAVIEA
MLBr_00862|M.leprae_Br4923 WDGVVPLLAKR-FRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDE
TH_4323|M.thermoresistible__bu WDSVAPLLADR-FRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDA
Mflv_2937|M.gilvum_PYR-GCK WDAVVALLAAR-FRIVRYDTRGAGRSAAPQRTSGFRLERYADDLAAVLDA
Mvan_3576|M.vanbaalenii_PYR-1 WDPVVALLADR-FRIVAYDTRGAGNSGAPKQTSAYTVDRFADDFAAVAAA
MSMEG_4280|M.smegmatis_MC2_155 WDGVVGELGDR-YRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDA
MMAR_1932|M.marinum_M WDPVA-ELLGDRYNVVAYDVRGSGESSCPASRSGYRLEQLVSDTGAVIDS
MAV_3670|M.avium_104 WDGVADELTGAPYNFVAYDVRGAGESSCPATRSGYGFAQLARDMGAVIDS
MAB_4023c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LSPGEPVHVLAHDWGSVGVWEYLR-----RPGASDRVASFTSVSGPSQDH
Rv2214c|M.tuberculosis_H37Rv LSPGEPVHVLAHDWGSVGVWEYLR-----RPGASDRVASFTSVSGPSQDH
MUL_3574|M.ulcerans_Agy99 LSPGQPVHVLGHDWGSVAIWDYLT-----RSGAADRVASFTSVSGPSQDQ
MLBr_00862|M.leprae_Br4923 LSPDRPVHVLAHDWGSVGVWEYLS-----RSGASDRVASFTSVSGPSQDQ
TH_4323|M.thermoresistible__bu LAPGQRVHVLAHDWGSAGVWEYLA-----RPEAEDRIASFTSVSGPSGDH
Mflv_2937|M.gilvum_PYR-GCK VSAEAPVHVLAHDRGSAGVWRYLA-----RPESRGRLASFTSVSGPAPEH
Mvan_3576|M.vanbaalenii_PYR-1 VGGDTPVHVLAHGWGAAGVWQYLK-----RADAPERVASLTSVSGPSPEH
MSMEG_4280|M.smegmatis_MC2_155 VSPDAPVHVLAHDWGSVGIWEYLS-----RQGSAARMVSFTSVSGPSTDH
MMAR_1932|M.marinum_M LGVDR-VHLLAHDWGSIQGWAAVT-----ADSVMEKVASFTSISGPHLQY
MAV_3670|M.avium_104 LGVGR-VHLLAHDWGSIQAWAAVTDQAIMGESVMDKVASFTSISGPHLNY
MAB_4023c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 LVNYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSS
Rv2214c|M.tuberculosis_H37Rv LVNYVYGGLRRPWRPRTFLRAISQTLRLSYMALFSVPVVAPLLLRVALSS
MUL_3574|M.ulcerans_Agy99 LVNYIFGGLRQPWRPKTFARALTQALRLSYMALFSVPVLAPLVLRATLSR
MLBr_00862|M.leprae_Br4923 LVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSS
TH_4323|M.thermoresistible__bu LARYVLDGLAAPYRPRRFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSK
Mflv_2937|M.gilvum_PYR-GCK VARYLRDTLARPQHPARFAGGLGHLAR--------------------LAA
Mvan_3576|M.vanbaalenii_PYR-1 VAGYVRAALTSPR---RFVRGAGQLVR--------------------LAA
MSMEG_4280|M.smegmatis_MC2_155 YGAYVRRGLARPYRPVQFARAVNLASRFSYWIPFSIPVLAPALMR---RG
MMAR_1932|M.marinum_M AGAFLRSGRTPRSVAQVARQLASSGYIGFFLCPVVPELFFRSGIGVKLVG
MAV_3670|M.avium_104 AGAFLRSARTPRAVARVVRQLIASGYIGFFLCPGAAELSFRAGIGVKVIA
MAB_4023c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 AAVR-RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRA
Rv2214c|M.tuberculosis_H37Rv AAVR-RNMVGDIPVDQIHHSETLARDAAHSVKTYPANYFRSFSSSRRGRA
MUL_3574|M.ulcerans_Agy99 ASVR-RNMVDNLPLDQIHHSDNLASDAANSVKTYPANYFRAFSRQSRTRG
MLBr_00862|M.leprae_Br4923 ATIR-RTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKG
TH_4323|M.thermoresistible__bu ALRRSLRLRDGVPADRLHHSDTFAADAARSIKVYGANFLRTLRHARTDH-
Mflv_2937|M.gilvum_PYR-GCK AAPR-----------------------AVTDKTLRANLFPVS----SGGD
Mvan_3576|M.vanbaalenii_PYR-1 AAPR-----------------------AATAKPYRANLRPAA----PAG-
MSMEG_4280|M.smegmatis_MC2_155 AARR---LQAIDTPGPKFQSENLDIDAANSLKIYRANAIRSFTHVRRDH-
MMAR_1932|M.marinum_M AFER---IGQSSTRSQRGQTPRSIGDYVNALNLYRANMPAGFVT--DGSS
MAV_3670|M.avium_104 ALER---IGHTSTRSQRRDTQRSLRDYLNGLQLYRQNMPAPMLA--PGPR
MAB_4023c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 IPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHP
Rv2214c|M.tuberculosis_H37Rv IPIVDVPVQLIVNSQDPYVRPYGYDQTARWVPRLWRRDIKAGHFSPMSHP
MUL_3574|M.ulcerans_Agy99 VPVIDVPVQLIVNTKDPYVRPYGYDETARWVPRLWRRDIKAGHFSPMSHP
MLBr_00862|M.leprae_Br4923 VPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHP
TH_4323|M.thermoresistible__bu --FVRVPVQLIVNTRDPYVRPHVYDETDRWVSRLWRRDIKAGHWSPMSHP
Mflv_2937|M.gilvum_PYR-GCK AHDVDIPVQLIVGSADPYPDPHLFEDRAGRPARLWRRDVKAGHVTPTSHP
Mvan_3576|M.vanbaalenii_PYR-1 -VPVDVPVQLIVPDHDPHVGPHVYDGMSASVSRLWRRDIKTGDLSPGSHP
MSMEG_4280|M.smegmatis_MC2_155 --YVQVPVQLICNRKDPVVRGEGYRDESKWVPLLWRRDLDAGHWAPFSHP
MMAR_1932|M.marinum_M LPQTSVPVQVLVPRKDMFVTPALQRFTGAIPGGGRVVPIEGGHWVVTSRP
MAV_3670|M.avium_104 LPETTVPVQTLVPRRDVFVTPALQRFTGAIPQRARVIEIEGGHWVVTSRP
MAB_4023c|M.abscessus_ATCC_199 ------------------------------------------MRVNPSEP
*.*
Mb2237c|M.bovis_AF2122/97 QVMAAAVHDFADLADGKQPSRALLRAQVGRPRG--YFGDTLVSVTGAGSG
Rv2214c|M.tuberculosis_H37Rv QVMAAAVHDFADLADGKQPSRALLRAQVGRPRG--YFGDTLVSVTGAGSG
MUL_3574|M.ulcerans_Agy99 QVMAAAVHDFADLVDGKPPSRALLRAQVGRPRK--YFGDTLVAVTGAGSG
MLBr_00862|M.leprae_Br4923 QVMAAAVHDLADLVDGKQPSRALLRAQVGRSRD--TFGDTLVSVTGAGSG
TH_4323|M.thermoresistible__bu QVLATAVTELADHLAGAPAGRALLRAQVGRPRE--YFGDMLVAITGAGGG
Mflv_2937|M.gilvum_PYR-GCK GILARALTQLVDHLDGAPAARELLRAQVGRPRK--AFGDTLVAVTGAASG
Mvan_3576|M.vanbaalenii_PYR-1 QVLARAVDQLVDHLGGAPAPRELLRAQVGRARK--VFGDTLVSVTGAASG
MSMEG_4280|M.smegmatis_MC2_155 RAIAQAVGEFVDHMEGAPPARALRRAEVARPRK--AFSDMLVSVTGAASG
MMAR_1932|M.marinum_M DVVARLTADWVDRVVAGTGDAAATVVR-AGPGE---VRGQLALVTGAGAG
MAV_3670|M.avium_104 DVIARLTTEWVDLQSAGAVAPQLTGERRELPGERREVRGRLALVTGAGAG
MAB_4023c|M.abscessus_ATCC_199 ---------------------------------------RLVVVTGAGSG
*. :***..*
Mb2237c|M.bovis_AF2122/97 IGRETALAFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSD
Rv2214c|M.tuberculosis_H37Rv IGRETALAFAREGA-EIVISDIDEATVKDTAAEIAARGGIAYPYVLDVSD
MUL_3574|M.ulcerans_Agy99 IGRETALAFAREGA-EVVLSDIDEATVKDTAAEIAARGGVAHPYVLDVSD
MLBr_00862|M.leprae_Br4923 IGRETALALARRGA-EVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSD
TH_4323|M.thermoresistible__bu IGRETALAFAREGA-EVIVSDIDEATAKDTAAEIAARGGVAHAYQLDVSD
Mflv_2937|M.gilvum_PYR-GCK IGRATALAFAHHGA-DVVISDVNAAGLDETARLVTSAGVHAYPYTVDVAD
Mvan_3576|M.vanbaalenii_PYR-1 IGRETALAFARAGA-DVVISDVDEAGLEQTARLVTAAGAAAHSYTVDVAD
MSMEG_4280|M.smegmatis_MC2_155 IGRATALEFARLGA-EIVVSDIDEAGAKATATAIDEAGGVAHAYGLDVAD
MMAR_1932|M.marinum_M IGRATAVELARQGARMVIIADRDLAAANESATQVRAAGAAAAVYQVDVSD
MAV_3670|M.avium_104 IGRATAVELARQGARKVVIVDRDRAAADQTADAVRAAGAGAAVYQVDVSD
MAB_4023c|M.abscessus_ATCC_199 IGRATAIRFAKRGA-HVVVTDLDLDTANETVDLILAMGRNASAVQLDVTD
*** **: :*: ** ::: * : . :. : * * :**:*
Mb2237c|M.bovis_AF2122/97 AEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLG
Rv2214c|M.tuberculosis_H37Rv AEAVEAFAERVSAEHGVPDIVVNNAGIGQAGRFLDTPAEQFDRVLAVNLG
MUL_3574|M.ulcerans_Agy99 TEAVEAFADQVSATHGLPDIVVNNAGVGQAGRFLDTPAEQFDRVLDVNLG
MLBr_00862|M.leprae_Br4923 AAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAVNLG
TH_4323|M.thermoresistible__bu AAAVDRFADEVCARHGVPDIVVNNAGIGHAGRFLDTPRDQWDRVLEVNLG
Mflv_2937|M.gilvum_PYR-GCK AAAVEAFAEQVCAEHGVPDVVVNNAGVGHAGFFLDTPAEEFDRVLDINFG
Mvan_3576|M.vanbaalenii_PYR-1 AAAVEAMAELVCAAHGVPDIVVNNAGVGHAGFFLDTPAEEFDRVLGINFG
MSMEG_4280|M.smegmatis_MC2_155 PDAVQRFVDDVCATHGVPDIVVNNAGIGHAGNFLDTPADQYERVLEVNFG
MMAR_1932|M.marinum_M ETAMNDLAAQVLDEHGVVDILVNNAGIGMAGRFLETTPQHWDAILGINVG
MAV_3670|M.avium_104 EAAMNDLAAQVRNEHGVVDILVNNAGIGMAGRFLETSPANWDAIMGVNVR
MAB_4023c|M.abscessus_ATCC_199 PAHWADVARYVSIEYGVPDVLVNNAGIALGGPFLKLTPADWDRLLSVNLM
.. * :*: *::*****:. .* **. . .:: :: :*.
Mb2237c|M.bovis_AF2122/97 GVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMF
Rv2214c|M.tuberculosis_H37Rv GVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMF
MUL_3574|M.ulcerans_Agy99 GVVNGCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATFMF
MLBr_00862|M.leprae_Br4923 GVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMF
TH_4323|M.thermoresistible__bu GVVNGCRAFAPRLVERGTGGHIVNIASMASYAPLQSLNAYCTSKAAVYMF
Mflv_2937|M.gilvum_PYR-GCK GVVNGCRSFGKRLADRGVGGHIVNVASMASYTPVNVMNAYCTSKAAVFMF
Mvan_3576|M.vanbaalenii_PYR-1 GVVNGCRSWGRRLVDRGTGGHIVNVASMASYTPVNVMNAYCTSKAAVFMF
MSMEG_4280|M.smegmatis_MC2_155 GVVNCCRAFGRRLVEQGTGGHIVNVASMAAYSPAGSMNAYATSKAAVFMF
MMAR_1932|M.marinum_M GVISGSRAFGAQMVERGQGGTIINIASAAAYLPSKSMVAYSTTKAAVLGF
MAV_3670|M.avium_104 GVIWGSRAFGAQMVERGQGGTIINVASAAAYLPSKSMVAYGTTKAAVLAL
MAB_4023c|M.abscessus_ATCC_199 GVVHGCRVFGEQMVERGSG-HIVNIASAAAFTPTAVMAPYSVSKAGVKML
**: .* :. ::.::* * *:*::* *:: * : .* .:**.. :
Mb2237c|M.bovis_AF2122/97 SDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQ
Rv2214c|M.tuberculosis_H37Rv SDCLRAELDAAGVGLTTICPGVIDTNIVATTGFHAP-GTDEEKIDGRRGQ
MUL_3574|M.ulcerans_Agy99 SDCLRAELDAADVGLTTICPGVINTNIVNTTRFDAPPGKGGDQLDGRRGQ
MLBr_00862|M.leprae_Br4923 SDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTP-TAKQERVRDRRGQ
TH_4323|M.thermoresistible__bu SDCLRAELDSAGIMLTTICPSTVNTNIIGSTRFNAP-DGLDDVVDTRREQ
Mflv_2937|M.gilvum_PYR-GCK SDCLRAELDSFGIGLTTICPGFISTNIVDTTRFSLA-QGRDDDVDVLRGR
Mvan_3576|M.vanbaalenii_PYR-1 SDCLRAELDSAGIGVTTICPGVIGTNIVDTTRFSLP-EARRDDAESIRRR
MSMEG_4280|M.smegmatis_MC2_155 SDCLRAELAHAGIGVTTLCPGMIDTGIVDTTRFDVP-AHKAGQVEARRAQ
MMAR_1932|M.marinum_M SEALRADLADEGISVTAVCPGFVNTNIAKSTVYAGMSTEQQERARQKAD-
MAV_3670|M.avium_104 SESLRADFADEGITVTAVCPGFVNTNIAKSTIYAGMSAQQQERARDRAD-
MAB_4023c|M.abscessus_ATCC_199 TECLRLELGPKGVGVSAICPGFINTNIGVHGTMVGVDPEIADASQRRIQR
::.** :: .: ::::**. :.*.*
Mb2237c|M.bovis_AF2122/97 ---IDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLP
Rv2214c|M.tuberculosis_H37Rv ---IDKMFALRSYGPDKVADAIVSAVKKKKPIRPVAPEAYALYGISRVLP
MUL_3574|M.ulcerans_Agy99 ---IDKMFALRSYGPDKVAKAIVSAVKKNKPIRPVAPEAYALYGISRVLP
MLBr_00862|M.leprae_Br4923 ---LDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLP
TH_4323|M.thermoresistible__bu ---LQKLFALRRFGPDKAAKAIVSAVKQNKPIRPVMPEAYFVYGVSRVLP
Mflv_2937|M.gilvum_PYR-GCK ---AQKGFSARKYGPEKVADAIVDAVRTNKAIRPVAPEARFVYGVAHALP
Mvan_3576|M.vanbaalenii_PYR-1 ---ARQGFAVRRVGPDKVAKAIVAAVQKNKPVRPVTTEAYLVYGVAHALP
MSMEG_4280|M.smegmatis_MC2_155 ---VKKTFQARRYGPEKVAKAVTSAVSRNQALRPVTPEAYVAYGVSRLFP
MMAR_1932|M.marinum_M -----AAYRRRNFTPEATARAIVKAIRSGPAVLPVAAESKVGYAMRRISP
MAV_3670|M.avium_104 -----AAYRRRNFTPEATAKAIVKAIKTGPAVVPIAAESRIGYALRRISP
MAB_4023c|M.abscessus_ATCC_199 IREFTEKLPWTPMSPELVARAVTRAIRLDLVVVPVKLESWFGYFVSRALP
*: .* :: *: : *: *: * : : *
Mb2237c|M.bovis_AF2122/97 QALR-------------STARLRVI--------------
Rv2214c|M.tuberculosis_H37Rv QALR-------------STARLRVI--------------
MUL_3574|M.ulcerans_Agy99 PALR-------------STARMRVI--------------
MLBr_00862|M.leprae_Br4923 QVLR-------------STARIRVI--------------
TH_4323|M.thermoresistible__bu QALR-------------STARGRVL--------------
Mflv_2937|M.gilvum_PYR-GCK QVLR-------------STARGGNFV-------------
Mvan_3576|M.vanbaalenii_PYR-1 QAMR-------------SAARGGNIM-------------
MSMEG_4280|M.smegmatis_MC2_155 AALR-------------RAARSQVL--------------
MMAR_1932|M.marinum_M SMIR-------------MFARLDIRQR------------
MAV_3670|M.avium_104 GAIR-------------LLARWDIRQT------------
MAB_4023c|M.abscessus_ATCC_199 AVNRRLMAPFGVDRFERLGARALVKQQEHYVPALVESVG
* **