ATP[c] + GL[c] -> GL3P[c] + H[c] + ADP[c]
reaction name: Glycerol kinase glpK
pathway: "C3 compounds, Glycerol metabolism"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3696c/glpK
metabolites:
  ATP[c] : adenosine-triphosphate
  GL[c] : Glycerol
  GL3P[c] : glycerol-3-phosphate
  H[c] : proton
  ADP[c] : adenosine-diphosphate

GL3P[c] + MK[c] -> MKH2[c] + DHAP[c]
reaction name: "glycerol-3-phosphate dehydrogenase glpD1, glpD2 "
pathway: "C3 compounds, Glycerol metabolism"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3302c/glpD2 OR Rv2249c/glpD1
metabolites:
  GL3P[c] : glycerol-3-phosphate
  MK[c] : ubiquinone-8
  MKH2[c] : ubiquinol-8
  DHAP[c] : dihydroxyacetone-phosphate

T3[c] + NAD[c] -> DGLYCERATE[c] + NADH[c]
reaction name: glyceraldehyde dehydrogenase aldC
pathway: "C3 compounds, glyceraldehyde"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv2858c/aldC OR Rv0458/-
metabolites:
  T3[c] : D-glyceraldehyde-3-phosphate
  NAD[c] : nicotinamide_adenine_dinucleotide
  DGLYCERATE[c] : D-glycerate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced

ATP[c] + DGLYCERATE[c] -> ADP[c] + 3PG[c]
reaction name: conserved hypothetical protein belonging to the glycerate kinase family
pathway: "C3 compounds, glycerate"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv2205c/-
metabolites:
  ATP[c] : adenosine-triphosphate
  DGLYCERATE[c] : D-glycerate
  ADP[c] : adenosine-diphosphate
  3PG[c] : 3-phosphoglycerate

ATP[c] + RIB[c] -> ADP[c] + R5P[c]
reaction name: ribokinase rbsK
pathway: "C5 compounds, D-ribose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv2436/rbsK
metabolites:
  ATP[c] : adenosine-triphosphate
  RIB[c] : Ribose
  ADP[c] : adenosine-diphosphate
  R5P[c] : D-ribose-5-phosphate

F1P[c] -> DHAP[c] + T3[c]
reaction name: fructose-bisphosphate aldolase fba
pathway: "C6 Compounds, Fructose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv0363c/fba
metabolites:
  F1P[c] : fructose-1-phosphate
  DHAP[c] : dihydroxyacetone-phosphate
  T3[c] : D-glyceraldehyde-3-phosphate

FRU[c] <=> GLC[c]
reaction name: Xylose isomerase
pathway: "C6 Compounds, Fructose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: orphan
metabolites:
  FRU[c] : fructose
  GLC[c] : -D-glucose

FRU[c] <=> MAN[c]
reaction name: Mannose isomerase
pathway: "C6 Compounds, mannose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: orphan
metabolites:
  FRU[c] : fructose
  MAN[c] : mannose

MAN6P[c] <=> F6P[c]
reaction name: mannose-6-phosphate isomerase manA
pathway: "C6 Compounds, mannose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3255c/manA
metabolites:
  MAN6P[c] : mannose-6-phosphate
  F6P[c] : D-fructose-6-phosphate

MAN1P[c] <=> MAN6P[c]
reaction name: "phosphomannomutase pmmA, pmmB"
pathway: "C6 Compounds, mannose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3257c/manB OR Rv3308/pmmB
metabolites:
  MAN1P[c] : -D-mannose_1-phosphate
  MAN6P[c] : mannose-6-phosphate

MAN1P[c] + GTP[c] -> GDPMAN[c] + PI[c]
reaction name: mannose-1-phosphate guanylyltransferase manB
pathway: "C6 Compounds, mannose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3264c/manB
metabolites:
  MAN1P[c] : -D-mannose_1-phosphate
  GTP[c] : guanosine-triphosphate
  GDPMAN[c] : guanosine_diphosphate_mannose
  PI[c] : phosphate

GDPMAN[c] + DPP[c] -> GDP[c] + PPM[c]
reaction name: "polyprenol mannose synthase, Ppm1"
pathway: "C6 Compounds, mannose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv2051c/ppm1
metabolites:
  GDPMAN[c] : guanosine_diphosphate_mannose
  DPP[c] : dimethylallyl-pyrophosphate
  GDP[c] : guanosine_diphosphate
  PPM[c] : polyprenolmannose

GDPMAN[c] -> GDPDHDOMAN[c]
reaction name: "Possible GDP-Mannose 4,6-dehydratase gca, gmdA "
pathway: GDP-D-rhamnose biosynthesis/ Fructose and mannose metabolism
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv0112/gca OR Rv1511/gmdA
metabolites:
  GDPMAN[c] : guanosine_diphosphate_mannose
  GDPDHDOMAN[c] : GDP-4-dehydro-6-deoxy-D-mannose

GDPDHDOMAN[c] -> GDPDHDOGAL[c]
reaction name: GDP-4-dehydro-6-deoxy-D-mannose epimerase / GDP-4-dehydro-6-L-deoxygalactose reductase
pathway: GDP-D-rhamnose biosynthesis/ Fructose and mannose metabolism
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv1512/epiA
metabolites:
  GDPDHDOMAN[c] : GDP-4-dehydro-6-deoxy-D-mannose
  GDPDHDOGAL[c] : GDP_4_dehydro_6_L_deoxygalactose

GDPDHDOGAL[c] + NADPH[c] -> GDPFUC[c] + NADP[c]
reaction name: GDP-4-dehydro-6-deoxy-D-mannose epimerase / GDP-4-dehydro-6-L-deoxygalactose reductase
pathway: GDP-D-rhamnose biosynthesis/ Fructose and mannose metabolism
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv1512/epiA
metabolites:
  GDPDHDOGAL[c] : GDP_4_dehydro_6_L_deoxygalactose
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  GDPFUC[c] : GDP_L_fucose
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate

ATP[c] + GLAC[c] -> ADP[c] + GAL1P[c]
reaction name: "galactokinase, galK"
pathway: "C6 Compounds, Galactose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv0620/galK
metabolites:
  ATP[c] : adenosine-triphosphate
  GLAC[c] : D-galactose
  ADP[c] : adenosine-diphosphate
  GAL1P[c] : -D-galactose_1-phosphate

GAL1P[c] + UTP[c] -> PPI[c] + UDPGAL[c]
reaction name: "UTP-hexose-1-phosphate uridylyltransferase, galTa, galTb"
pathway: "C6 Compounds, Galactose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv0619/galTb OR Rv0618/galTa
metabolites:
  GAL1P[c] : -D-galactose_1-phosphate
  UTP[c] : uridine-triphosphate
  PPI[c] : pyrophosphate
  UDPGAL[c] : UDP-galactose

UDPG[c] <=> UDPGAL[c]
reaction name: "UDP-glucose 4-epimerase galE1, galE2, galE3"
pathway: "C6 Compounds, Galactose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3634c/galE1 OR Rv0501/galE2 OR Rv0536/galE3
metabolites:
  UDPG[c] : UDP-D-glucose
  UDPGAL[c] : UDP-galactose

UTP[c] + G1P[c] -> PPI[c] + UDPG[c]
reaction name: "UTP-glucose-1-phosphate uridylyltransferase, galU"
pathway: "C6 Compounds, Galactose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv0993/galU
metabolites:
  UTP[c] : uridine-triphosphate
  G1P[c] : -D-glucose_1-phosphate
  PPI[c] : pyrophosphate
  UDPG[c] : UDP-D-glucose

bDG6P[c] <=> IP[c]
reaction name: "inositol-1-phosphate synthase, Ino1"
pathway: "Inositols, MYO-INOSITOL SYNTHESIS"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv0046c/ino1 OR Rv2612c/pgsA1 AND Rv1822/pgsA2
metabolites:
  bDG6P[c] : -D-glucose-6-phosphate
  IP[c] : inositol_phosphate

IP[c] -> PI[c] + MI[c]
reaction name: myoinositol phosphatase
pathway: "Inositols, MYO-INOSITOL SYNTHESIS"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv2701c/suhB
metabolites:
  IP[c] : inositol_phosphate
  PI[c] : phosphate
  MI[c] : myo-inositol

MLT[c] -> 2 GLC[c]
reaction name: alpha-glucosidase
pathway: "Disaccharides, maltose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv2471/aglA
metabolites:
  MLT[c] : maltose
  GLC[c] : -D-glucose

SUC[c] -> GLC[c] + FRU[c]
reaction name: alpha-glucosidase
pathway: "Disaccharides, Sucrose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv2471/aglA
metabolites:
  SUC[c] : sucrose
  GLC[c] : -D-glucose
  FRU[c] : fructose

h2o[c] + CELB[c] -> 2 bDGLC[c]
reaction name: beta-glucosidase bglS
pathway: "Disaccharides, cellobiose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv0186/bglS
metabolites:
  h2o[c] : water
  CELB[c] : cellobiose
  bDGLC[c] : -D-glucose

UDPG[c] + G6P[c] -> UDP[c] + TRE6P[c]
reaction name: "alpha,alpha-trehalose- phosphate synthase otsA"
pathway: Trehalose synthesis
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3490/otsA
metabolites:
  UDPG[c] : UDP-D-glucose
  G6P[c] : -D-glucose-6-phosphate
  UDP[c] : uridine-diphosphate
  TRE6P[c] : trehalose_6-phosphate

PI[c] + MLT[c] -> bDGLC[c] + bDG1P[c]
reaction name: Maltose phosphorylase
pathway: "Disaccharides, Trehalose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3401/-
metabolites:
  PI[c] : phosphate
  MLT[c] : maltose
  bDGLC[c] : -D-glucose
  bDG1P[c] : -D-Glucose_1-phosphate

bDG1P[c] <=> bDG6P[c]
reaction name: possible beta-phosphoglucomutase
pathway:
subsystem: Central carbon metabolism
enzymes: Rv3400/-
metabolites:
  bDG1P[c] : -D-Glucose_1-phosphate
  bDG6P[c] : -D-glucose-6-phosphate

MLT[c] <=> TRE[c]
reaction name: trehalose synthase treS (TreS Pathway)
pathway: "Disaccharides, Trehalose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: orphan
metabolites:
  MLT[c] : maltose
  TRE[c] : trehalose

TRE6P[c] -> PI[c] + TRE[c]
reaction name: trehalose-phosphatase otsB2
pathway: "Disaccharides, Trehalose"
subsystem: Carbon metabolism (excluding central carbon metabolism)
enzymes: Rv3372/otsB2
metabolites:
  TRE6P[c] : trehalose_6-phosphate
  PI[c] : phosphate
  TRE[c] : trehalose

NAD[c] + FOR[c] -> NADH[c] + CO2[c]
reaction name: formate dehydrogenase fdhF
pathway: Organic Acids
subsystem: Other
enzymes: Rv2900c/fdhF
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  FOR[c] : formate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  CO2[c] : carbon_dioxide

ATP[c] + GLC[c] -> ADP[c] + G6P[c]
reaction name: glucokinase
pathway: Phosphorylation of glucose
subsystem: Central carbon metabolism
enzymes: Rv0650/-
metabolites:
  ATP[c] : adenosine-triphosphate
  GLC[c] : -D-glucose
  ADP[c] : adenosine-diphosphate
  G6P[c] : -D-glucose-6-phosphate

ATP[c] + bDGLC[c] -> ADP[c] + bDG6P[c]
reaction name: glucokinase
pathway: Phosphorylation of glucose
subsystem: Central carbon metabolism
enzymes: Rv0650/-
metabolites:
  ATP[c] : adenosine-triphosphate
  bDGLC[c] : -D-glucose
  ADP[c] : adenosine-diphosphate
  bDG6P[c] : -D-glucose-6-phosphate

GLC[c] + 40_n_41_POLYP[c] -> G6P[c] + 40_n_1_41_POLYP[c]
reaction name: polyphosphate glucokinase ppgK
pathway: Phosphorylation of glucose
subsystem: Central carbon metabolism
enzymes: Rv2702/ppgK
metabolites:
  GLC[c] : -D-glucose
  40_n_41_POLYP[c] : (polyphosphate)(n)
  G6P[c] : -D-glucose-6-phosphate
  40_n_1_41_POLYP[c] : (polyphosphate)(n-1)

bDGLC[c] + 40_n_41_POLYP[c] -> bDG6P[c] + 40_n_1_41_POLYP[c]
reaction name: polyphosphate glucokinase
pathway: Phosphorylation of glucose
subsystem: Central carbon metabolism
enzymes: Rv2702/ppgK
metabolites:
  bDGLC[c] : -D-glucose
  40_n_41_POLYP[c] : (polyphosphate)(n)
  bDG6P[c] : -D-glucose-6-phosphate
  40_n_1_41_POLYP[c] : (polyphosphate)(n-1)

G6P[c] <=> bDG6P[c]
reaction name: glucose-6-phosphate isomerase
pathway: Interconversion between alpha and beta forms of glucose-6-phosphate
subsystem: Central carbon metabolism
enzymes: Rv0946c/pgi
metabolites:
  G6P[c] : -D-glucose-6-phosphate
  bDG6P[c] : -D-glucose-6-phosphate

G6P[c] <=> G1P[c]
reaction name: phosphoglucomutase pgmA
pathway: Interconversion between glucose-6-phosphate and glucose-1-phosphate
subsystem: Central carbon metabolism
enzymes: Rv3068c/pgmA
metabolites:
  G6P[c] : -D-glucose-6-phosphate
  G1P[c] : -D-glucose_1-phosphate

bDG6P[c] <=> F6P[c]
reaction name: glucose-6-phosphate isomerase
pathway: Interconversion between glucose-6-phosphate and fructose-6-phosphate
subsystem: Central carbon metabolism
enzymes: Rv0946c/pgi
metabolites:
  bDG6P[c] : -D-glucose-6-phosphate
  F6P[c] : D-fructose-6-phosphate

G6P[c] <=> F6P[c]
reaction name: "glucose-6-phosphate isomerase, pgi"
pathway: Interconversion between glucose-6-phosphate and fructose-6-phosphate
subsystem: Central carbon metabolism
enzymes: Rv0946c/pgi
metabolites:
  G6P[c] : -D-glucose-6-phosphate
  F6P[c] : D-fructose-6-phosphate

ATP[c] + F6P[c] -> ADP[c] + FDP[c]
reaction name: "6-phosphofructokinase, pfkA or pfkB"
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv3010c/pfkA OR Rv2029c/pfkB
metabolites:
  ATP[c] : adenosine-triphosphate
  F6P[c] : D-fructose-6-phosphate
  ADP[c] : adenosine-diphosphate
  FDP[c] : "fructose-1,6-bisphosphate"

FDP[c] -> F6P[c] + PI[c]
reaction name: fructose-bisphosphatase
pathway: Gluconeogenesis
subsystem: Central carbon metabolism
enzymes: Rv1099c/glpX
metabolites:
  FDP[c] : "fructose-1,6-bisphosphate"
  F6P[c] : D-fructose-6-phosphate
  PI[c] : phosphate

FDP[c] <=> DHAP[c] + G3P[c]
reaction name: fructose-bisphosphate aldolase
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv0363c/fba
metabolites:
  FDP[c] : "fructose-1,6-bisphosphate"
  DHAP[c] : dihydroxyacetone-phosphate
  G3P[c] : D-glyceraldehyde-3-phosphate

DHAP[c] <=> G3P[c]
reaction name: triose-phosphate isomerase
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv1438/tpiA
metabolites:
  DHAP[c] : dihydroxyacetone-phosphate
  G3P[c] : D-glyceraldehyde-3-phosphate

NAD[c] + PI[c] + G3P[c] <=> NADH[c] + 13PDG[c]
reaction name: glyceraldehyde-3-phosphate dehydrogenase
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv1436/gap
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  PI[c] : phosphate
  G3P[c] : D-glyceraldehyde-3-phosphate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  13PDG[c] : "1,3-diphosphateglycerate"

ADP[c] + 13PDG[c] <=> ATP[c] + 3PG[c]
reaction name: phosphoglycerate kinase
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv1437/pgk
metabolites:
  ADP[c] : adenosine-diphosphate
  13PDG[c] : "1,3-diphosphateglycerate"
  ATP[c] : adenosine-triphosphate
  3PG[c] : 3-phosphoglycerate

3PG[c] <=> 2PG[c]
reaction name: "phosphoglycerate mutase gpm2, gpm1"
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv3214/gpm2 OR Rv0489/gpm1
metabolites:
  3PG[c] : 3-phosphoglycerate
  2PG[c] : 2-phosphoglycerate

2PG[c] <=> PEP[c]
reaction name: phosphopyruvate hydratase
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv1023/eno
metabolites:
  2PG[c] : 2-phosphoglycerate
  PEP[c] : phosphoenolpyruvate

H[c] + ADP[c] + PEP[c] -> ATP[c] + PYR[c]
reaction name: pyruvate kinase
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv1617/pykA
metabolites:
  H[c] : proton
  ADP[c] : adenosine-diphosphate
  PEP[c] : phosphoenolpyruvate
  ATP[c] : adenosine-triphosphate
  PYR[c] : pyruvate

PYR[c] + LIPO[c] + 0.001 THI[c] -> CO2[c] + ADLIPO[c]
reaction name: "pyruvate dehydrogenase (acetyl-transferring), E1 component, aceE"
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv2241/aceE
metabolites:
  PYR[c] : pyruvate
  LIPO[c] : enzyme N6-(lipoyl)lysine
  THI[c] : thiamine
  CO2[c] : carbon_dioxide
  ADLIPO[c] : enzyme_N6-(S-acetyldihydrolipoyl)lysine

ADLIPO[c] + COA[c] <=> DLIPO[c] + ACCOA[c]
reaction name: "dihydrolipoyllysine-residue acetyltransferase pdhC, E2 component of PDH"
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv2215/dlaT
metabolites:
  ADLIPO[c] : enzyme_N6-(S-acetyldihydrolipoyl)lysine
  COA[c] : coenzyme_A
  DLIPO[c] : dlipo
  ACCOA[c] : acetyl-CoA

NAD[c] + DLIPO[c] <=> NADH[c] + LIPO[c]
reaction name: "dihydrolipoyl dehydrogenase lpdC, E3 component of PDH"
pathway: Glycolysis
subsystem: Central carbon metabolism
enzymes: Rv0462/lpd
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  DLIPO[c] : dlipo
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  LIPO[c] : enzyme N6-(lipoyl)lysine

ACCOA[c] + OA[c] -> COA[c] + CIT[c]
reaction name: "citrate synthasev citA, gltA1, gltA2"
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv0896/gltA OR Rv0889c/citA OR Rv1131/gltA1
metabolites:
  ACCOA[c] : acetyl-CoA
  OA[c] : oxaloacetate
  COA[c] : coenzyme_A
  CIT[c] : citrate

CIT[c] <=> CISACONITATE[c]
reaction name: Aconitase
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv1475c/acn
metabolites:
  CIT[c] : citrate
  CISACONITATE[c] : cisaconitate

CISACONITATE[c] <=> ICIT[c]
reaction name: Aconitase
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv1475c/acn
metabolites:
  CISACONITATE[c] : cisaconitate
  ICIT[c] : isocitrate

NADP[c] + ICIT[c] -> NADPH[c] + CO2[c] + AKG[c]
reaction name: "isocitrate dehydrogenase (NADP), icd1, icd2"
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv3339c/icd1 OR Rv0066c/icd2
metabolites:
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  ICIT[c] : isocitrate
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  CO2[c] : carbon_dioxide
  AKG[c] : -ketoglutarate

LIPO[c] + AKG[c] -> CO2[c] + SDLIPO[c]
reaction name: oxoglutarate dehydrogenase
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: orphan
metabolites:
  LIPO[c] : enzyme N6-(lipoyl)lysine
  AKG[c] : -ketoglutarate
  CO2[c] : carbon_dioxide
  SDLIPO[c] : succinyldihydrolipoyl

COA[c] + SDLIPO[c] -> DLIPO[c] + SUCCOA[c]
reaction name: dihydrolipoyllysine-residue succinyltransferase
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: orphan
metabolites:
  COA[c] : coenzyme_A
  SDLIPO[c] : succinyldihydrolipoyl
  DLIPO[c] : dlipo
  SUCCOA[c] : succinyl-CoA

AKG[c] -> CO2[c] + SUCCSAL[c]
reaction name: "Alpha-Ketoglutarate decarboxylase kgd (menD, sucA)"
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv1248c/kgd OR Rv0555/menD
metabolites:
  AKG[c] : -ketoglutarate
  CO2[c] : carbon_dioxide
  SUCCSAL[c] : succinate_semialdehyde_(succinic_semialdehyde)

COA[c] + AKG[c] + FERI[c] -> CO2[c] + SUCCOA[c] + FERO[c]
reaction name: a-ketoglutarate: ferredoxin oxidoreductase
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv2454c/- AND Rv2455c/-
metabolites:
  COA[c] : coenzyme_A
  AKG[c] : -ketoglutarate
  FERI[c] : oxidized ferredoxin
  CO2[c] : carbon_dioxide
  SUCCOA[c] : succinyl-CoA
  FERO[c] : reduced ferredoxin

ADP[c] + PI[c] + SUCCOA[c] <=> ATP[c] + COA[c] + SUCC[c]
reaction name: succinate-CoA ligase
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv0952/sucD AND Rv0951/sucC
metabolites:
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  SUCCOA[c] : succinyl-CoA
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  SUCC[c] : succinate

FUM[c] <=> MAL[c]
reaction name: fumarate hydratase
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv1098c/fumC
metabolites:
  FUM[c] : fumarate
  MAL[c] : malate

NAD[c] + MAL[c] <=> NADH[c] + OA[c]
reaction name: malate dehydrogenase
pathway: Citrate cycle (TCA cycle)
subsystem: Central carbon metabolism
enzymes: Rv1240/mdh
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  MAL[c] : malate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  OA[c] : oxaloacetate

ATP[c] + COA[c] + AC[c] -> PPI[c] + ACCOA[c] + AMP[c]
reaction name: acetyl-CoA synthetase
pathway: Pyruvate metabolism
subsystem: Other
enzymes: Rv3667/acs
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  AC[c] : acetate
  PPI[c] : pyrophosphate
  ACCOA[c] : acetyl-CoA
  AMP[c] : adenosine-monophosphate

NAD[c] + ACAL[c] -> NADH[c] + AC[c]
reaction name: aldehyde dehydrogenase (NAD)
pathway: Pyruvate metabolism
subsystem: Other
enzymes: Rv0458/-
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  ACAL[c] : acetaldehyde
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  AC[c] : acetate

ATP[c] + PI[c] + PYR[c] -> PPI[c] + PEP[c] + AMP[c]
reaction name: pyruvate phosphate dikinase ppdK
pathway: Gluconeogenesis
subsystem: Central carbon metabolism
enzymes: Rv1127c/ppdK
metabolites:
  ATP[c] : adenosine-triphosphate
  PI[c] : phosphate
  PYR[c] : pyruvate
  PPI[c] : pyrophosphate
  PEP[c] : phosphoenolpyruvate
  AMP[c] : adenosine-monophosphate

NAD[c] + LAC[c] <=> NADH[c] + PYR[c]
reaction name: D-lactate dehydrogenase
pathway: Pyruvate metabolism
subsystem: Central carbon metabolism
enzymes: Rv0728c/serA2
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  LAC[c] : D-lactate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  PYR[c] : pyruvate

NAD[c] + LLAC[c] <=> NADH[c] + PYR[c]
reaction name: "L-lactate dehydrogenase, lldD1 or lldD2"
pathway: Pyruvate metabolism
subsystem: Central carbon metabolism
enzymes: Rv1872c/lldD2 OR Rv0694/lldD1
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  LLAC[c] : lactate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  PYR[c] : pyruvate

NAD[c] + MAL[c] <=> NADH[c] + CO2[c] + PYR[c]
reaction name: malic enzyme (malate dehydrogenase (oxaloacetate-decarboxylating))
pathway: Pyruvate metabolism
subsystem: Central carbon metabolism
enzymes: Rv2332/mez
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  MAL[c] : malate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  CO2[c] : carbon_dioxide
  PYR[c] : pyruvate

NADH[c] + ACAL[c] <=> NAD[c] + ETH[c]
reaction name: "alcohol dehydrogenase adhA, adh, adhE1, adhB"
pathway: Pyruvate metabolism
subsystem: Other
enzymes: Rv1862/adhA OR Rv1530/adh OR Rv0162c/adhE1 OR Rv0761c/adhB
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACAL[c] : acetaldehyde
  NAD[c] : nicotinamide_adenine_dinucleotide
  ETH[c] : ethanol

NADPH[c] + ACAL[c] <=> NADP[c] + ETH[c]
reaction name: alcohol dehydrogenase (nadp dependent) adhC
pathway: Pyruvate metabolism
subsystem: Other
enzymes: Rv3045/adhC
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACAL[c] : acetaldehyde
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  ETH[c] : ethanol

ATP[c] + AC[c] -> ADP[c] + ACETYLP[c]
reaction name: acetate kinase ackA
pathway: Pyruvate metabolism
subsystem: Other
enzymes: Rv0409/ackA
metabolites:
  ATP[c] : adenosine-triphosphate
  AC[c] : acetate
  ADP[c] : adenosine-diphosphate
  ACETYLP[c] : acetylphosphate

COA[c] + ACETYLP[c] <=> PI[c] + ACCOA[c]
reaction name: phosphate acetyltransferase pta
pathway: Pyruvate metabolism
subsystem: Other
enzymes: Rv0408/pta
metabolites:
  COA[c] : coenzyme_A
  ACETYLP[c] : acetylphosphate
  PI[c] : phosphate
  ACCOA[c] : acetyl-CoA

ACETYLP[c] -> PI[c] + AC[c]
reaction name: acylphosphatase
pathway: Pyruvate metabolism
subsystem: Other
enzymes: Rv2922A/acyP
metabolites:
  ACETYLP[c] : acetylphosphate
  PI[c] : phosphate
  AC[c] : acetate

COA[c] + PROPIONYLP[c] <=> PI[c] + PROPIONYLCOA[c]
reaction name: phosphate acetyltransferase
pathway: Propanoate metabolism
subsystem: Central carbon metabolism
enzymes: Rv0408/pta
metabolites:
  COA[c] : coenzyme_A
  PROPIONYLP[c] : propionyl-P
  PI[c] : phosphate
  PROPIONYLCOA[c] : propionyl-CoA

ATP[c] + PROPANOATE[c] -> ADP[c] + PROPIONYLP[c]
reaction name: acetate kinase
pathway: Propanoate metabolism
subsystem: Central carbon metabolism
enzymes: Rv0409/ackA
metabolites:
  ATP[c] : adenosine-triphosphate
  PROPANOATE[c] : propanoate
  ADP[c] : adenosine-diphosphate
  PROPIONYLP[c] : propionyl-P

SMMALONYLCOA[c] -> CO2[c] + PROPIONYLCOA[c]
reaction name: methylmalonyl-CoA decarboxylase
pathway: Propanoate metabolism
subsystem: Central carbon metabolism
enzymes: Rv0974c/accD2 OR Rv3280/accD5
metabolites:
  SMMALONYLCOA[c] : (S)-methyl-malonyl-CoA
  CO2[c] : carbon_dioxide
  PROPIONYLCOA[c] : propionyl-CoA

ATP[c] + COA[c] + PROPANOATE[c] -> PPI[c] + AMP[c] + PROPIONYLCOA[c]
reaction name: acetyl-CoA synthetase
pathway: Propanoate metabolism
subsystem: Central carbon metabolism
enzymes: orphan
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  PROPANOATE[c] : propanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  PROPIONYLCOA[c] : propionyl-CoA

OA[c] + PROPIONYLCOA[c] -> COA[c] + 2METHYLCITRATE[c]
reaction name: "methycitrate synthase, prpC"
pathway: Propanoate metabolism - methycitrate cycle
subsystem: Central carbon metabolism
enzymes: Rv1131/gltA1
metabolites:
  OA[c] : oxaloacetate
  PROPIONYLCOA[c] : propionyl-CoA
  COA[c] : coenzyme_A
  2METHYLCITRATE[c] : 2-methylcitrate

2METHYLCITRATE[c] -> 2METHYLCISACONITATE[c]
reaction name: "2-methylcitrate dehydrase, prpD"
pathway: Propanoate metabolism - methycitrate cycle
subsystem: Central carbon metabolism
enzymes: Rv1130/-
metabolites:
  2METHYLCITRATE[c] : 2-methylcitrate
  2METHYLCISACONITATE[c] : 2-methyl-cis-aconitate

2METHYLCISACONITATE[c] -> METHYLISOCITRATE[c]
reaction name: "aconitate hydratase, can"
pathway: Propanoate metabolism - methycitrate cycle
subsystem: Central carbon metabolism
enzymes: Rv1475c/acn
metabolites:
  2METHYLCISACONITATE[c] : 2-methyl-cis-aconitate
  METHYLISOCITRATE[c] : methylisocitrate

METHYLISOCITRATE[c] -> PYR[c] + SUCC[c]
reaction name: 2-methylisocitrate lyase/isocitrarte lyase ICL1 (aceA or icl gene) or ILC2 (aceAa and aceAb genes)
pathway: Propanoate metabolism - methycitrate cycle
subsystem: Central carbon metabolism
enzymes: Rv0467/icl
metabolites:
  METHYLISOCITRATE[c] : methylisocitrate
  PYR[c] : pyruvate
  SUCC[c] : succinate

MK[c] + PROPIONYLCOA[c] -> MKH2[c] + ACRCOA[c]
reaction name: acyl-CoA dehydrogenase
pathway: Propanoate metabolism
subsystem: Central carbon metabolism
enzymes: Rv3140/fadE23
metabolites:
  MK[c] : ubiquinone-8
  PROPIONYLCOA[c] : propionyl-CoA
  MKH2[c] : ubiquinol-8
  ACRCOA[c] : acrylyl-CoA

NADP[c] + G6P[c] + 0.001 F420[c] -> NADPH[c] + D6PGL[c]
reaction name: "glucose-6-phosphate 1-dehydrogenase zwf, zwf2"
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv1447c/zwf2 OR Rv1121/zwf1
metabolites:
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  G6P[c] : -D-glucose-6-phosphate
  F420[c] : coenzyme F420
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  D6PGL[c] : D-glucono--lactone-6-phosphate

D6PGL[c] -> D6PGC[c]
reaction name: 6-phosphogluconolactonase
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv1445c/devB
metabolites:
  D6PGL[c] : D-glucono--lactone-6-phosphate
  D6PGC[c] : 6-phospho-D-gluconate

NADP[c] + D6PGC[c] -> NADPH[c] + CO2[c] + RL5P[c]
reaction name: "phosphogluconate dehydrogenase, gnd1 or gnd2"
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv1122/gnd2 OR Rv1844c/gnd1
metabolites:
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  D6PGC[c] : 6-phospho-D-gluconate
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  CO2[c] : carbon_dioxide
  RL5P[c] : D-ribulose-5-phosphate

RL5P[c] <=> X5P[c]
reaction name: ribulose-phosphate 3-epimerase rpe
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv0408/pta
metabolites:
  RL5P[c] : D-ribulose-5-phosphate
  X5P[c] : D-xylulose-5-phosphate

RL5P[c] <=> R5P[c]
reaction name: "ribose-5-phosphate isomerase, rpiB"
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv2465c/-
metabolites:
  RL5P[c] : D-ribulose-5-phosphate
  R5P[c] : D-ribose-5-phosphate

R1P[c] <=> R5P[c]
reaction name: phosphoglucomutase
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv3068c/pgmA
metabolites:
  R1P[c] : ribose-1-phosphate
  R5P[c] : D-ribose-5-phosphate

R5P[c] + 0.001 THI[c] + X5P[c] -> G3P[c] + S7P[c]
reaction name: transketolase tkt
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv1449c/tkt
metabolites:
  R5P[c] : D-ribose-5-phosphate
  THI[c] : thiamine
  X5P[c] : D-xylulose-5-phosphate
  G3P[c] : D-glyceraldehyde-3-phosphate
  S7P[c] : D-sedoheptulose-7-phosphate

G3P[c] + 0.001 THI[c] + S7P[c] -> R5P[c] + X5P[c]
reaction name: transketolase tkt
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv1449c/tkt
metabolites:
  G3P[c] : D-glyceraldehyde-3-phosphate
  THI[c] : thiamine
  S7P[c] : D-sedoheptulose-7-phosphate
  R5P[c] : D-ribose-5-phosphate
  X5P[c] : D-xylulose-5-phosphate

0.001 THI[c] + X5P[c] + E4P[c] -> F6P[c] + G3P[c]
reaction name: transketolase tkt
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv1449c/tkt
metabolites:
  THI[c] : thiamine
  X5P[c] : D-xylulose-5-phosphate
  E4P[c] : D-erythrose-4-phosphate
  F6P[c] : D-fructose-6-phosphate
  G3P[c] : D-glyceraldehyde-3-phosphate

F6P[c] + G3P[c] + 0.001 THI[c] -> X5P[c] + E4P[c]
reaction name: transketolase tkt
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv1449c/tkt
metabolites:
  F6P[c] : D-fructose-6-phosphate
  G3P[c] : D-glyceraldehyde-3-phosphate
  THI[c] : thiamine
  X5P[c] : D-xylulose-5-phosphate
  E4P[c] : D-erythrose-4-phosphate

G3P[c] + S7P[c] <=> F6P[c] + E4P[c]
reaction name: transaldolase tal
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv1448c/tal
metabolites:
  G3P[c] : D-glyceraldehyde-3-phosphate
  S7P[c] : D-sedoheptulose-7-phosphate
  F6P[c] : D-fructose-6-phosphate
  E4P[c] : D-erythrose-4-phosphate

ATP[c] + RIB[c] -> ADP[c] + DR5P[c]
reaction name: ribokinase rbsK
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv2436/rbsK
metabolites:
  ATP[c] : adenosine-triphosphate
  RIB[c] : Ribose
  ADP[c] : adenosine-diphosphate
  DR5P[c] : deoxyribose-5-phosphate

DR5P[c] -> G3P[c] + ACAL[c]
reaction name: deoxyribose-phosphate aldolase
pathway: Pentose phosphate pathway
subsystem: Central carbon metabolism
enzymes: Rv0478/deoC
metabolites:
  DR5P[c] : deoxyribose-5-phosphate
  G3P[c] : D-glyceraldehyde-3-phosphate
  ACAL[c] : acetaldehyde

PYR[c] + BIOTIN_CO2[c] <=> OA[c] + 0.999 BIOTIN[c]
reaction name: pyruvate carboxylase
pathway: Anapleurotic reactions
subsystem: Central carbon metabolism
enzymes: Rv2967c/pca
metabolites:
  PYR[c] : pyruvate
  BIOTIN_CO2[c] : BCCP-biotin-CO2
  OA[c] : oxaloacetate
  BIOTIN[c] : biotin

GDP[c] + CO2[c] + PEP[c] <=> GTP[c] + OA[c]
reaction name: phosphoenolpyruvate carboxykinase (GTP) pckA
pathway: Anapleurotic reactions
subsystem: Central carbon metabolism
enzymes: Rv0211/pckA
metabolites:
  GDP[c] : guanosine_diphosphate
  CO2[c] : carbon_dioxide
  PEP[c] : phosphoenolpyruvate
  GTP[c] : guanosine-triphosphate
  OA[c] : oxaloacetate

ICIT[c] -> SUCC[c] + GLX[c]
reaction name: isocitrate lyase ICL1 (aceA or icl gene) or ILC2 (aceAa and aceAb genes). Note that In Mycobacterium tuberculosis strain CDC155...
pathway: Glyoxylate shunt
subsystem: Central carbon metabolism
enzymes: Rv0467/icl
metabolites:
  ICIT[c] : isocitrate
  SUCC[c] : succinate
  GLX[c] : glyoxylate

ACCOA[c] + GLX[c] -> COA[c] + MAL[c]
reaction name: malate synthase
pathway: Glyoxylate shunt
subsystem: Central carbon metabolism
enzymes: Rv1837c/glcB
metabolites:
  ACCOA[c] : acetyl-CoA
  GLX[c] : glyoxylate
  COA[c] : coenzyme_A
  MAL[c] : malate

NAD[c] + GLAL[c] -> NADH[c] + GLYCOLATE[c]
reaction name: glycolaldehyde dehydrogenase
pathway: Glyoxylate shunt
subsystem: Central carbon metabolism
enzymes: orphan
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  GLAL[c] : glycolaldehyde
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  GLYCOLATE[c] : glycolate

GLYCOLATE[c] + O2[c] -> GLX[c] + H2O2[c]
reaction name: (S)-2-hydroxy-acid oxidase
pathway: Glyoxylate shunt
subsystem: Central carbon metabolism
enzymes: Rv1257c/-
metabolites:
  GLYCOLATE[c] : glycolate
  O2[c] : oxygen
  GLX[c] : glyoxylate
  H2O2[c] : hydrogen_peroxide

NADP[c] + METTHF[c] <=> NADPH[c] + METHF[c]
reaction name: methylenetetrahydrofolate dehydrogenase (NADP)
pathway: One carbon pool by folate
subsystem: Other
enzymes: Rv3356c/folD
metabolites:
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  METTHF[c] : "5,10-methylene-THF"
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  METHF[c] : "5,10-methenyl-THF"

METHF[c] <=> FTHF[c]
reaction name: methenyltetrahydrofolate cyclohydrolase
pathway: One carbon pool by folate
subsystem: Other
enzymes: Rv3356c/folD
metabolites:
  METHF[c] : "5,10-methenyl-THF"
  FTHF[c] : 4-fumaryl-acetoacetate

METTHF[c] + FADH2[c] -> MTHF[c] + FAD[c]
reaction name: "5,10-methylenetetrahydrofolate reductase (FADH2)"
pathway: One carbon pool by folate
subsystem: Other
enzymes: orphan
metabolites:
  METTHF[c] : "5,10-methylene-THF"
  FADH2[c] : flavin adenine dinucleotide reduced
  MTHF[c] : 5-methyl-THF
  FAD[c] : flavin adenine dinucleotide

ATP[c] + SLF[c] -> PPI[c] + APS[c]
reaction name: ATP sulfurylase
pathway: Sulfate metabolism
subsystem: Other
enzymes: Rv1285/cysD
metabolites:
  ATP[c] : adenosine-triphosphate
  SLF[c] : sulfate
  PPI[c] : pyrophosphate
  APS[c] : adenylyl-sulfate

ATP[c] + APS[c] -> ADP[c] + PAPS[c]
reaction name: "adenylyl-sulfate kinase, cysNC"
pathway: Sulfate metabolism
subsystem: Other
enzymes: Rv1286/cysN
metabolites:
  ATP[c] : adenosine-triphosphate
  APS[c] : adenylyl-sulfate
  ADP[c] : adenosine-diphosphate
  PAPS[c] : 3-phosphoadenylyl-sulfate

APS[c] + RTHIO[c] -> AMP[c] + OTHIO[c] + H2SO3[c]
reaction name: 3-phosphoadenylylsulfate (PAPS) reductase cysH (thioredoxin-dependent)
pathway: Sulfate metabolism
subsystem: Other
enzymes: Rv2392/cysH
metabolites:
  APS[c] : adenylyl-sulfate
  RTHIO[c] : reduced_thioredoxin
  AMP[c] : adenosine-monophosphate
  OTHIO[c] : thioredoxin_disulfide
  H2SO3[c] : sulfurous_acid_

6 FERO[c] + H2SO3[c] <=> 6 FERI[c] + H2S[c]
reaction name: sulfite reductase nirA
pathway: Sulfate metabolism
subsystem: Other
enzymes: Rv2391/nirA
metabolites:
  FERO[c] : reduced ferredoxin
  H2SO3[c] : sulfurous_acid_
  FERI[c] : oxidized ferredoxin
  H2S[c] : hydrogen_sulfide

PAP[c] -> PI[c] + AMP[c]
reaction name: "3,5-bisphosphate nucleotidase"
pathway: Sulfate metabolism
subsystem: Other
enzymes: orphan
metabolites:
  PAP[c] : "adenosine_3,5-bisphosphate"
  PI[c] : phosphate
  AMP[c] : adenosine-monophosphate

MKH2[c] + 0.001 MOLYBDENUM[c] + NO3[c] -> 2 H[c] + MK[c] + NO2[c]
reaction name: "nitrate reductase narGHIJ, or fused narX"
pathway: Nitrogen metabolism
subsystem: Other
enzymes: Rv1161/narG AND Rv1162/narH AND Rv1164/narI AND Rv1163/narJ OR Rv1736c/narX
metabolites:
  MKH2[c] : ubiquinol-8
  MOLYBDENUM[c] : molybdenum
  NO3[c] : nitrate
  H[c] : proton
  MK[c] : ubiquinone-8
  NO2[c] : nitrite

MK[c] + NADH[c] -> 4 H[c] + MKH2[c] + NAD[c]
reaction name: "type I NADH dehydrogenase, nuoA-N"
pathway: Energy metabolism
subsystem: Other
enzymes: Rv3145/nuoA AND Rv3146/nuoB AND Rv3147/nuoC AND Rv3148/nuoD AND Rv3149/nuoE AND Rv3150/nuoF AND Rv3151/nuoG AND Rv3152/nuoH AND Rv3153/nuoI AND Rv3154/nuoJ AND Rv3155/nuoK AND Rv3156/nuoL ...
metabolites:
  MK[c] : ubiquinone-8
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  H[c] : proton
  MKH2[c] : ubiquinol-8
  NAD[c] : nicotinamide_adenine_dinucleotide

MK[c] + NADH[c] -> MKH2[c] + NAD[c]
reaction name: "type II NADH dehydrogenase, ndhA or ndh"
pathway: Energy metabolism
subsystem: Other
enzymes: Rv1854c/ndh OR Rv0392c/ndhA
metabolites:
  MK[c] : ubiquinone-8
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  MKH2[c] : ubiquinol-8
  NAD[c] : nicotinamide_adenine_dinucleotide

MK[c] + NADPH[c] -> MKH2[c] + NADP[c]
reaction name: NADPH-dependent quinone oxidoreductase activity of LpdA - slow compared to NAD pathway
pathway: Energy metabolism
subsystem: Other
enzymes: Rv0462/lpd
metabolites:
  MK[c] : ubiquinone-8
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  MKH2[c] : ubiquinol-8
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate

MK[c] + SUCC[c] <=> MKH2[c] + FUM[c]
reaction name: "succinate dehydrogenase, sdhABCD"
pathway: Energy metabolism
subsystem: Central carbon metabolism
enzymes: Rv3318/sdhA AND Rv3319/sdhB AND Rv3316/sdhC AND Rv3317/sdhD
metabolites:
  MK[c] : ubiquinone-8
  SUCC[c] : succinate
  MKH2[c] : ubiquinol-8
  FUM[c] : fumarate

SUCC[c] + FAD[c] <=> FUM[c] + FADH2[c]
reaction name: "probable succinate dehydrogenase, sdhABCD OR probable fumarate reductase, frdABCD"
pathway: Energy metabolism
subsystem: Central carbon metabolism
enzymes: Rv3318/sdhA AND Rv3319/sdhB AND Rv3316/sdhC AND Rv3317/sdhD OR Rv1552/frdA AND Rv1553/frdB AND Rv1554/frdC AND Rv1555/frdD
metabolites:
  SUCC[c] : succinate
  FAD[c] : flavin adenine dinucleotide
  FUM[c] : fumarate
  FADH2[c] : flavin adenine dinucleotide reduced

NADPH[c] + FE3[c] <=> NADP[c] + FE2[c]
reaction name: "ferredoxin-NADP reductase fprA, fprB, fdR"
pathway: Energy metabolism
subsystem: Other
enzymes: Rv3106/fprA
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  FE3[c] : ferric iron
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  FE2[c] : ferrous iron

MKH2[c] + 2 HEME_FE3[c] <=> MK[c] + 2 HEME_FE2[c]
reaction name: "aa3-type cytochrome c oxidase, ctaCDE AND cytochrome bc1 Or bd-type menaquinol oxidase"
pathway: Energy metabolism
subsystem: Other
enzymes: Rv2194/qcrC AND Rv2195/qcrA AND Rv2196/qcrB AND Rv2196/qcrB AND Rv1451/ctaB AND Rv1456c/- AND Rv3029c/fixA AND Rv3028c/fixB AND Rv2200c/ctaC AND Rv3043c/ctaD AND Rv2193/ctaE AND Rv.../-
metabolites:
  MKH2[c] : ubiquinol-8
  HEME_FE3[c] : heme-fe3
  MK[c] : ubiquinone-8
  HEME_FE2[c] : heme-fe2

0.5 O2[c] + 2 HEME_FE2[c] -> 6 H[c] + 2 HEME_FE3[c]
reaction name: "aa3-type cytochrome c oxidase, ctaCDE AND cytochrome bc1"
pathway: Energy metabolism
subsystem: Other
enzymes: Rv2194/qcrC AND Rv2195/qcrA AND Rv2196/qcrB AND Rv2196/qcrB AND Rv1451/ctaB AND Rv1456c/- AND Rv3029c/fixA AND Rv3028c/fixB AND Rv2200c/ctaC AND Rv3043c/ctaD AND Rv2193/ctaE AND Rv.../-
metabolites:
  O2[c] : oxygen
  HEME_FE2[c] : heme-fe2
  H[c] : proton
  HEME_FE3[c] : heme-fe3

0.5 O2[c] + 2 HEME_FE2[c] -> 2 H[c] + 2 HEME_FE3[c]
reaction name: bd-type menaquinol oxidase
pathway: Energy metabolism
subsystem: Other
enzymes: Rv1623c/cydA AND Rv1622c/cydB
metabolites:
  O2[c] : oxygen
  HEME_FE2[c] : heme-fe2
  H[c] : proton
  HEME_FE3[c] : heme-fe3

4 H[c] + ADP[c] + PI[c] <=> ATP[c]
reaction name: Complex V: ATP synthase (atpABCDEFGH)
pathway: Energy metabolism
subsystem: Other
enzymes: Rv1308/atpA AND Rv1304/atpB AND Rv1311/atpC AND Rv1310/atpD AND Rv1305/atpE AND Rv1306/atpF AND Rv1309/atpG AND Rv1307/atpH
metabolites:
  H[c] : proton
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  ATP[c] : adenosine-triphosphate

ATP[c] -> ADP[c] + PI[c]
reaction name: Possible Mg2+ Transport P-Type ATPase C MGTC
pathway: Energy metabolism
subsystem: Other
enzymes: Rv1811/mgtC
metabolites:
  ATP[c] : adenosine-triphosphate
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate

PPI[c] -> 2 PI[c]
reaction name: Inorganic pyrophosphatase
pathway: Energy metabolism
subsystem: Other
enzymes: Rv3628/ppa
metabolites:
  PPI[c] : pyrophosphate
  PI[c] : phosphate

PPI[c] -> H[c] + 2 PI[c]
reaction name: proton-pumping inorganic diphosphatase
pathway: Energy metabolism
subsystem: Other
enzymes: Rv3628/ppa
metabolites:
  PPI[c] : pyrophosphate
  H[c] : proton
  PI[c] : phosphate

ATP[c] + 40_n_1_41_POLYP[c] <=> ADP[c] + 40_n_41_POLYP[c]
reaction name: polyphosphate kinase
pathway: Energy metabolism
subsystem: Other
enzymes: Rv2984/ppk
metabolites:
  ATP[c] : adenosine-triphosphate
  40_n_1_41_POLYP[c] : (polyphosphate)(n-1)
  ADP[c] : adenosine-diphosphate
  40_n_41_POLYP[c] : (polyphosphate)(n)

NADP[c] + 2 FERO[c] <=> NADPH[c] + 2 FERI[c]
reaction name: "ferredoxin-NADP reductase fprA, fprB"
pathway: Energy metabolism
subsystem: Other
enzymes: Rv3106/fprA OR Rv0886/fprB
metabolites:
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  FERO[c] : reduced ferredoxin
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  FERI[c] : oxidized ferredoxin

2 H2O2[c] -> O2[c]
reaction name: "catalase-peroxidase, katG"
pathway:
subsystem: Other
enzymes: Rv1908c/katG
metabolites:
  H2O2[c] : hydrogen_peroxide
  O2[c] : oxygen

GLU[c] -> CO2[c] + GABA[c]
reaction name: glutamate decarboxylase gadB
pathway: "Amino acid degradation, Glutamate family, Glutamate"
subsystem: Amino acid metabolism
enzymes: Rv3432c/gadB
metabolites:
  GLU[c] : glutamate
  CO2[c] : carbon_dioxide
  GABA[c] : 4-aminobutyrate_(GABA)

AKG[c] + GABA[c] <=> SUCCSAL[c] + GLU[c]
reaction name: 4-aminobutyrate transaminase gabT
pathway: "Amino acid degradation, Glutamate family, Glutamate"
subsystem: Amino acid metabolism
enzymes: Rv2589/gabT
metabolites:
  AKG[c] : -ketoglutarate
  GABA[c] : 4-aminobutyrate_(GABA)
  SUCCSAL[c] : succinate_semialdehyde_(succinic_semialdehyde)
  GLU[c] : glutamate

NADP[c] + SUCCSAL[c] -> NADPH[c] + SUCC[c]
reaction name: "succinate-semialdehyde dehydrogenase gabD1, gabD2"
pathway: "Amino acid degradation, Glutamate family, Glutamate"
subsystem: Amino acid metabolism
enzymes: Rv0234c/gabD1 OR Rv1731/gabD2
metabolites:
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  SUCCSAL[c] : succinate_semialdehyde_(succinic_semialdehyde)
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  SUCC[c] : succinate

FAD[c] + PRO[c] -> FADH2[c] + P5C[c]
reaction name: Proline dehydrogenase
pathway: "Amino acid degradation, Glutamate family, Proline"
subsystem: Amino acid metabolism
enzymes: Rv1188/-
metabolites:
  FAD[c] : flavin adenine dinucleotide
  PRO[c] : proline
  FADH2[c] : flavin adenine dinucleotide reduced
  P5C[c] : pyrroline_5-carboxylate

NAD[c] + P5C[c] -> NADH[c] + HYDROXYGLU[c]
reaction name: Probable pyrroline-5-carboxylate dehydrogenase
pathway: "Amino acid degradation, Glutamate family, 4-hydroxyproline"
subsystem: Amino acid metabolism
enzymes: Rv1187/rocA
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  P5C[c] : pyrroline_5-carboxylate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  HYDROXYGLU[c] : D-4-hydroxy-glutarate

AKG[c] + HYDROXYGLU[c] -> GLU[c] + HYDROXYAKG[c]
reaction name: Transaminase (aminotransferases)
pathway: "Amino acid degradation, Glutamate family, 4-hydroxyproline degradation"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  AKG[c] : -ketoglutarate
  HYDROXYGLU[c] : D-4-hydroxy-glutarate
  GLU[c] : glutamate
  HYDROXYAKG[c] : D-4-hydroxy-2-keto-glutarate

HYDROXYAKG[c] <=> PYR[c] + GLX[c]
reaction name: 4-hydroxy-2-oxoglutarate aldolase
pathway: Glyoxylate shunt
subsystem: Central carbon metabolism
enzymes: Rv1223/htrA
metabolites:
  HYDROXYAKG[c] : D-4-hydroxy-2-keto-glutarate
  PYR[c] : pyruvate
  GLX[c] : glyoxylate

NAD[c] + P5C[c] -> NADH[c] + GLU[c]
reaction name: 1-pyrroline-5-carboxylate dehydrogenase rocA
pathway: "Amino acid degradation, Glutamate family, Proline"
subsystem: Amino acid metabolism
enzymes: Rv1187/rocA
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  P5C[c] : pyrroline_5-carboxylate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  GLU[c] : glutamate

ARG[c] -> CITR[c] + NH3[c]
reaction name: arginine deiminase arcA
pathway: "Amino acid degradation, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1001/arcA
metabolites:
  ARG[c] : L-arginine
  CITR[c] : citrulline
  NH3[c] : ammonia

AKG[c] + ORN[c] -> GLU[c] + GLUGSAL[c]
reaction name: "ornithine aminotransferase rocD1, rocD2"
pathway: "Amino acid degradation, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv2321c/rocD2 OR Rv2322c/rocD1
metabolites:
  AKG[c] : -ketoglutarate
  ORN[c] : ornithine
  GLU[c] : glutamate
  GLUGSAL[c] : L-glutamate_-semialdehyde

ORN[c] + CAP[c] -> PI[c] + CITR[c]
reaction name: ornithine carbamoyltransferase
pathway: "Amino acid degradation, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1656/argF
metabolites:
  ORN[c] : ornithine
  CAP[c] : carbamoyl-phosphate
  PI[c] : phosphate
  CITR[c] : citrulline

ORN[c] -> CO2[c] + PTRSC[c]
reaction name: ornithine decarboxylase adi
pathway: "Amino acid degradation, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv2531c/-
metabolites:
  ORN[c] : ornithine
  CO2[c] : carbon_dioxide
  PTRSC[c] : putrescine

PTRSC[c] + SAM[c] -> SPRMD[c] + 5MTA[c]
reaction name: spermidine synthase
pathway: "Amino acid degradation, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv2601/speE
metabolites:
  PTRSC[c] : putrescine
  SAM[c] : S-adenosyl-L-methionine
  SPRMD[c] : spermidine
  5MTA[c] : 5-methylthioadenosine

UREA[c] -> CO2[c] + NH3[c]
reaction name: "Urease (3 subunits: alpha ureA, Beta ureB AND gamma ureC), and urease accessory proteins: ureD, ureF, ureG"
pathway: "Amino acid degradation, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  UREA[c] : urea
  CO2[c] : carbon_dioxide
  NH3[c] : ammonia

AKG[c] + ILE[c] <=> GLU[c] + OMVAL[c]
reaction name: Branched-chain-amino-acid transaminase
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv2210c/ilvE
metabolites:
  AKG[c] : -ketoglutarate
  ILE[c] : L-isoleucine
  GLU[c] : glutamate
  OMVAL[c] : 2-keto-3-methyl-valerate

LIPO[c] + OXOMETHYLPENTANOATE[c] -> CO2[c] + 2MBUTLIPO[c]
reaction name: 3-methyl-2-oxobutanoate dehydrogenase (alpha subunit AND beta subunit)
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv2497c/pdhA AND Rv2496c/pdhB
metabolites:
  LIPO[c] : enzyme N6-(lipoyl)lysine
  OXOMETHYLPENTANOATE[c] : 2-oxo-3-methylpentanoate
  CO2[c] : carbon_dioxide
  2MBUTLIPO[c] : enzyme_N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine

COA[c] + 2MBUTLIPO[c] <=> DLIPO[c] + 2MBUTCOA[c]
reaction name: dihydrolipoyllysine-residue acetyltransferase
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv2495c/pdhC
metabolites:
  COA[c] : coenzyme_A
  2MBUTLIPO[c] : enzyme_N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
  DLIPO[c] : dlipo
  2MBUTCOA[c] : S-2-methyl-butyryl-CoA

MK[c] + 2MBUTCOA[c] -> MKH2[c] + 2MBECOA[c]
reaction name: acyl-CoA dehydrogenase
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv3140/fadE23
metabolites:
  MK[c] : ubiquinone-8
  2MBUTCOA[c] : S-2-methyl-butyryl-CoA
  MKH2[c] : ubiquinol-8
  2MBECOA[c] : "2-methylbut-2-enoyl-CoA (tiglyl-CoA, 2-methylcrotonoyl-CoA)"

2MBECOA[c] -> HMBUTCOA[c]
reaction name: "enoyl-CoA hydratase echA8, echA6, echA14, echA12"
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv1070c/echA8 OR Rv0905/echA6 OR Rv2486/echA14 OR Rv1472/echA12
metabolites:
  2MBECOA[c] : "2-methylbut-2-enoyl-CoA (tiglyl-CoA, 2-methylcrotonoyl-CoA)"
  HMBUTCOA[c] : 3-hydroxybutyryl-CoA

NAD[c] + HMBUTCOA[c] -> NADH[c] + MAACCOA[c]
reaction name: 3-hydroxyacyl-CoA dehydrogenase
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv3774/echA21 OR Rv1144/-
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  HMBUTCOA[c] : 3-hydroxybutyryl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  MAACCOA[c] : maacoa

COA[c] + MAACCOA[c] <=> ACCOA[c] + PROPIONYLCOA[c]
reaction name: acetyl-CoA acetyltransferase fadA3
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv1074c/fadA3
metabolites:
  COA[c] : coenzyme_A
  MAACCOA[c] : maacoa
  ACCOA[c] : acetyl-CoA
  PROPIONYLCOA[c] : propionyl-CoA

PROPIONYLCOA[c] + BIOTIN_CO2[c] -> SMMALONYLCOA[c] + 0.999 BIOTIN[c]
reaction name: "acetyl-CoA/propionyl-CoA carboxylase carboxytransferase subunit: 6 paralogues in Mtb: accD1, accD2, accD3, accD4, accD5, accD6"
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv0904c/accD3 OR Rv2502c/accD1 OR Rv0974c/accD2 OR Rv0904c/accD3 OR Rv3799c/accD4 OR Rv3280/accD5 OR Rv2247/accD6
metabolites:
  PROPIONYLCOA[c] : propionyl-CoA
  BIOTIN_CO2[c] : BCCP-biotin-CO2
  SMMALONYLCOA[c] : (S)-methyl-malonyl-CoA
  BIOTIN[c] : biotin

SMMALONYLCOA[c] <=> RMMALONYLCOA[c]
reaction name: methylmalonyl-CoA epimerase
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv0855/far orA
metabolites:
  SMMALONYLCOA[c] : (S)-methyl-malonyl-CoA
  RMMALONYLCOA[c] : (R)-methylmalonyl-CoA

RMMALONYLCOA[c] + 0.001 COB_III[c] -> SUCCOA[c]
reaction name: methylmalonyl-CoA mutase (small subunit mutA AND large subunit mutB)
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv1492/mutA AND Rv1493/mutB
metabolites:
  RMMALONYLCOA[c] : (R)-methylmalonyl-CoA
  COB_III[c] : COB-III
  SUCCOA[c] : succinyl-CoA

SUCCOA[c] + 0.001 COB_III[c] -> RMMALONYLCOA[c]
reaction name: methylmalonyl-CoA mutase (small subunit mutA AND large subunit mutB)
pathway: "Amino acid degradation, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv1492/mutA AND Rv1493/mutB
metabolites:
  SUCCOA[c] : succinyl-CoA
  COB_III[c] : COB-III
  RMMALONYLCOA[c] : (R)-methylmalonyl-CoA

LIPO[c] + MOP[c] -> CO2[c] + 3MBUTLIPO[c]
reaction name: "3-methyl-2-oxobutanoate dehydrogenase pdhA, pdhB"
pathway: "Amino acid degradation, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv2496c/pdhB AND Rv2497c/pdhA
metabolites:
  LIPO[c] : enzyme N6-(lipoyl)lysine
  MOP[c] : 4-methyl-2-oxopentanoate
  CO2[c] : carbon_dioxide
  3MBUTLIPO[c] : enzyme_N6-(S-[3-methylbutanoyl]dihydrolipoyl)lysine

COA[c] + 3MBUTLIPO[c] <=> DLIPO[c] + 3MBUTCOA[c]
reaction name: "dihydrolipoyllysine-residue acetyltransferase, pdhC"
pathway: "Amino acid degradation, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv2495c/pdhC
metabolites:
  COA[c] : coenzyme_A
  3MBUTLIPO[c] : enzyme_N6-(S-[3-methylbutanoyl]dihydrolipoyl)lysine
  DLIPO[c] : dlipo
  3MBUTCOA[c] : S-3-methyl-butyryl-CoA

MK[c] + 3MBUTCOA[c] -> MKH2[c] + 3MBECOA[c]
reaction name: acyl-CoA dehydrogenase
pathway: "Amino acid degradation, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv3140/fadE23
metabolites:
  MK[c] : ubiquinone-8
  3MBUTCOA[c] : S-3-methyl-butyryl-CoA
  MKH2[c] : ubiquinol-8
  3MBECOA[c] : 3-methylbut-2-enoyl-CoA (3-methylcrotonyl-CoA)

BIOTIN_CO2[c] + 3MBECOA[c] -> 0.999 BIOTIN[c] + MGLUTCOA[c]
reaction name: "acetyl-CoA/propionyl-CoA carboxylase carboxytransferase subunit: 6 paralogues in Mtb: accD1, accD2, accD3, accD4, accD5, accD6"
pathway: "Amino acid degradation, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv0904c/accD3 OR Rv2502c/accD1 OR Rv0974c/accD2 OR Rv0904c/accD3 OR Rv3799c/accD4 OR Rv3280/accD5 OR Rv2247/accD6
metabolites:
  BIOTIN_CO2[c] : BCCP-biotin-CO2
  3MBECOA[c] : 3-methylbut-2-enoyl-CoA (3-methylcrotonyl-CoA)
  BIOTIN[c] : biotin
  MGLUTCOA[c] : 3-methylglutaconyl-CoA

MGLUTCOA[c] -> HMGLUTCOA[c]
reaction name: methylglutaconyl-CoA hydratase
pathway: "Amino acid degradation, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  MGLUTCOA[c] : 3-methylglutaconyl-CoA
  HMGLUTCOA[c] : 3-hydroxy-3-methyl-glutaryl-CoA

HMGLUTCOA[c] -> ACCOA[c] + ACTAC[c]
reaction name: hydroxymethylglutaryl-CoA lyase
pathway: "Amino acid degradation, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  HMGLUTCOA[c] : 3-hydroxy-3-methyl-glutaryl-CoA
  ACCOA[c] : acetyl-CoA
  ACTAC[c] : acetoacetate

ATP[c] + COA[c] + ACTAC[c] -> PPI[c] + AMP[c] + AACCOA[c]
reaction name: acetoacetate-CoA ligase
pathway: "Amino acid degradation, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  ACTAC[c] : acetoacetate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  AACCOA[c] : acetoacetyl-CoA

SUCCOA[c] + ACTAC[c] <=> SUCC[c] + AACCOA[c]
reaction name: "3-oxoacid CoA-transferase scoA, scoB"
pathway: "Amino acid degradation, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv2504c/scoA AND Rv2503c/scoB
metabolites:
  SUCCOA[c] : succinyl-CoA
  ACTAC[c] : acetoacetate
  SUCC[c] : succinate
  AACCOA[c] : acetoacetyl-CoA

LIPO[c] + OMVAL[c] -> CO2[c] + IBUTLIPO[c]
reaction name: 3-methyl-2-oxobutanoate dehydrogenase (alpha subunit pdhA AND beta subunit pdhB)
pathway: "Amino acid degradation, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv2497c/pdhA AND Rv2496c/pdhB
metabolites:
  LIPO[c] : enzyme N6-(lipoyl)lysine
  OMVAL[c] : 2-keto-3-methyl-valerate
  CO2[c] : carbon_dioxide
  IBUTLIPO[c] : ibutlipo

COA[c] + IBUTLIPO[c] <=> DLIPO[c] + IBUTCOA[c]
reaction name: dihydrolipoyllysine-residue acetyltransferase
pathway: "Amino acid degradation, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv2495c/pdhC
metabolites:
  COA[c] : coenzyme_A
  IBUTLIPO[c] : ibutlipo
  DLIPO[c] : dlipo
  IBUTCOA[c] : ibutcoa

MK[c] + IBUTCOA[c] -> MKH2[c] + MACRCOA[c]
reaction name: acyl-CoA dehydrogenase
pathway: "Amino acid degradation, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv3140/fadE23
metabolites:
  MK[c] : ubiquinone-8
  IBUTCOA[c] : ibutcoa
  MKH2[c] : ubiquinol-8
  MACRCOA[c] : methylacrylyl-CoA

MACRCOA[c] -> HIBUTCOA[c]
reaction name: enoyl-CoA hydratase
pathway: "Amino acid degradation, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv1070c/echA8 OR Rv0905/echA6 OR Rv2486/echA14 OR Rv1472/echA12
metabolites:
  MACRCOA[c] : methylacrylyl-CoA
  HIBUTCOA[c] : 3-hydroxy-isobutyryl-CoA

HIBUTCOA[c] -> COA[c] + HIBUT[c]
reaction name: 3-hydroxyisobutyryl-CoA hydrolase
pathway: "Amino acid degradation, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  HIBUTCOA[c] : 3-hydroxy-isobutyryl-CoA
  COA[c] : coenzyme_A
  HIBUT[c] : 3-hydroxy-isobutyrate

NAD[c] + HIBUT[c] -> NADH[c] + METHYMALONATE[c]
reaction name: 3-hydroxyacyl-CoA dehydrogenase
pathway: "Amino acid degradation, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv1144/- OR Rv0751c/mmsB
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  HIBUT[c] : 3-hydroxy-isobutyrate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  METHYMALONATE[c] : methylmalonate

NAD[c] + COA[c] + METHYMALONATE[c] -> NADH[c] + CO2[c] + PROPIONYLCOA[c]
reaction name: methylmalonate-semialdehyde dehydrogenase (acylating)
pathway: "Amino acid degradation, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv0753c/mmsA
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  METHYMALONATE[c] : methylmalonate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  CO2[c] : carbon_dioxide
  PROPIONYLCOA[c] : propionyl-CoA

ISUCC[c] -> OA[c] + NH3[c]
reaction name: spontaneous iminosuccinate deamination
pathway: "Amino acid degradation, The aspartate family, Aspartate"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  ISUCC[c] : iminoaspartate_(-iminosuccinate)
  OA[c] : oxaloacetate
  NH3[c] : ammonia

ASP[c] -> CO2[c] + bALA[c]
reaction name: "aspartate decarboxylase, panD"
pathway: "Amino acid degradation, The aspartate family, Aspartate"
subsystem: Amino acid metabolism
enzymes: Rv3601c/panD
metabolites:
  ASP[c] : L-aspartate
  CO2[c] : carbon_dioxide
  bALA[c] : -alanine

ASN[c] -> NH3[c] + ASP[c]
reaction name: asparaginase ansA
pathway: "Amino acid degradation, The aspartate family, Asparagine"
subsystem: Amino acid metabolism
enzymes: Rv1538c/ansA
metabolites:
  ASN[c] : L-asparagine
  NH3[c] : ammonia
  ASP[c] : L-aspartate

NAD[c] + THR[c] -> NADH[c] + 2A3KB[c]
reaction name: L-threonine 3-dehydrogenase
pathway: "Amino acid degradation, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: Rv2259/adhE2
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  THR[c] : threonine
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  2A3KB[c] : 2-amino-3-oxobutanoate

2A3KB[c] -> CO2[c] + AMINOACETONE[c]
reaction name: spontaneous decarboxylation
pathway: "Amino acid degradation, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  2A3KB[c] : 2-amino-3-oxobutanoate
  CO2[c] : carbon_dioxide
  AMINOACETONE[c] : aminoacetone

NADH[c] + AMINOACETONE[c] -> NAD[c] + 1_AMINO_PROPAN_2_OL[c]
reaction name: spontaneous
pathway: "Amino acid degradation, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  AMINOACETONE[c] : aminoacetone
  NAD[c] : nicotinamide_adenine_dinucleotide
  1_AMINO_PROPAN_2_OL[c] : 1-amino-propan-2-ol

NH3[c] + OBUT[c] + CYS[c] -> LLCT[c]
reaction name: cystathionine gamma-lyase
pathway: "Amino acid degradation, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: Rv1079/metB
metabolites:
  NH3[c] : ammonia
  OBUT[c] : 2-oxobutanoate
  CYS[c] : L-cysteine
  LLCT[c] : cystathionine

LYS[c] -> CO2[c] + CADA[c]
reaction name: lysine decarboxylase
pathway: "Amino acid degradation, The aspartate family, Lysine"
subsystem: Amino acid metabolism
enzymes: Rv2531c/-
metabolites:
  LYS[c] : L-lysine
  CO2[c] : carbon_dioxide
  CADA[c] : cadaverine

PI[c] + O2[c] + OBUT[c] -> CO2[c] + PROPIONYLP[c]
reaction name: spontaneous
pathway: "Amino acid degradation, The aspartate family, methionine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  PI[c] : phosphate
  O2[c] : oxygen
  OBUT[c] : 2-oxobutanoate
  CO2[c] : carbon_dioxide
  PROPIONYLP[c] : propionyl-P

SAP[c] + THF[c] -> METTHF[c] + NH3[c] + DHLIPOYLPROTEIN[c]
reaction name: aminomethyltransferase gcvT
pathway: "Amino acid degradation, The serine family, Glycine"
subsystem: Amino acid metabolism
enzymes: Rv2211c/gcvT
metabolites:
  SAP[c] : H-protein-S-(aminomethyldihydrolipoyl)lysine
  THF[c] : tetrahydrofolate
  METTHF[c] : "5,10-methylene-THF"
  NH3[c] : ammonia
  DHLIPOYLPROTEIN[c] : enzyme_N6-(dihydrolipoyl)lysine

THF[c] + SER[c] <=> METTHF[c] + GLY[c]
reaction name: "glycine hydroxymethyltransferase glyA, glyA2"
pathway: "Amino acid degradation, The serine family, Glycine"
subsystem: Amino acid metabolism
enzymes: Rv1093/glyA OR Rv0070c/glyA2
metabolites:
  THF[c] : tetrahydrofolate
  SER[c] : serine
  METTHF[c] : "5,10-methylene-THF"
  GLY[c] : glycine

GLY[c] + LIPOYLPROTEIN[c] -> CO2[c] + SAP[c]
reaction name: glycine dehydrogenase gcvB
pathway: "Amino acid degradation, The serine family, Glycine"
subsystem: Amino acid metabolism
enzymes: Rv1832/gcvB
metabolites:
  GLY[c] : glycine
  LIPOYLPROTEIN[c] : H-protein-(lipoyl)lysine
  CO2[c] : carbon_dioxide
  SAP[c] : H-protein-S-(aminomethyldihydrolipoyl)lysine

NAD[c] + GLY[c] -> NADH[c] + GLX[c] + NH3[c]
reaction name: glycine dehydrogenase gcvB
pathway: "Amino acid degradation, The serine family, Glycine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  GLY[c] : glycine
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  GLX[c] : glyoxylate
  NH3[c] : ammonia

NAD[c] + DHLIPOYLPROTEIN[c] <=> NADH[c] + LIPOYLPROTEIN[c]
reaction name: dihydrolipoyl dehydrogenase lpd
pathway: "Amino acid degradation, The serine family, Glycine"
subsystem: Amino acid metabolism
enzymes: Rv0462/lpd
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  DHLIPOYLPROTEIN[c] : enzyme_N6-(dihydrolipoyl)lysine
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  LIPOYLPROTEIN[c] : H-protein-(lipoyl)lysine

SER[c] -> PYR[c] + NH3[c]
reaction name: L-serine ammonia-lyase (dehydratase) sdaA
pathway: "Amino acid degradation, The serine family, Serine"
subsystem: Amino acid metabolism
enzymes: Rv0069c/sdaA
metabolites:
  SER[c] : serine
  PYR[c] : pyruvate
  NH3[c] : ammonia

CYS[c] -> PYR[c] + H2S[c] + NH3[c]
reaction name: cysteine desulfhydrase
pathway: "Amino acid degradation, The serine family, cysteine"
subsystem: Amino acid metabolism
enzymes: Rv1464/csd
metabolites:
  CYS[c] : L-cysteine
  PYR[c] : pyruvate
  H2S[c] : hydrogen_sulfide
  NH3[c] : ammonia

AKG[c] + TYR[c] <=> GLU[c] + 4HPP[c]
reaction name: L-Tyrosine:2-oxoglutarate aminotransferase
pathway: "Amino acid degradation, The aromatic family, Tyrosine"
subsystem: Amino acid metabolism
enzymes: Rv3565/aspB OR Rv0337c/aspC
metabolites:
  AKG[c] : -ketoglutarate
  TYR[c] : tyrosine
  GLU[c] : glutamate
  4HPP[c] : p-hydroxyphenylpyruvate

O2[c] + 4HPP[c] -> CO2[c] + HOMOGEN[c]
reaction name: 4-hydroxyphenylpyruvate dioxygenase
pathway: "Amino acid degradation, The aromatic family, Tyrosine"
subsystem: Amino acid metabolism
enzymes: Rv1322A/-
metabolites:
  O2[c] : oxygen
  4HPP[c] : p-hydroxyphenylpyruvate
  CO2[c] : carbon_dioxide
  HOMOGEN[c] : homogentisate

O2[c] + HOMOGEN[c] -> MACAC[c]
reaction name: "homogentisate 1,2-dioxygenase"
pathway: "Amino acid degradation, The aromatic family, Tyrosine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  O2[c] : oxygen
  HOMOGEN[c] : homogentisate
  MACAC[c] : 4-maleyl-acetoacetate

MACAC[c] <=> FUACAC[c]
reaction name: maleylacetoacetate isomerase
pathway: "Amino acid degradation, The aromatic family, Tyrosine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  MACAC[c] : 4-maleyl-acetoacetate
  FUACAC[c] : -L-fucose_1-phosphate

FUACAC[c] -> FUM[c] + ACTAC[c]
reaction name: fumarylacetoacetase
pathway: "Amino acid degradation, The aromatic family, Tyrosine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  FUACAC[c] : -L-fucose_1-phosphate
  FUM[c] : fumarate
  ACTAC[c] : acetoacetate

AKG[c] + PHE[c] <=> GLU[c] + PHPYR[c]
reaction name: L-Phenylalanine:2-oxoglutarate aminotransferase
pathway: "Amino acid degradation, The aromatic family, Phenylalanine"
subsystem: Amino acid metabolism
enzymes: Rv3565/aspB OR Rv0337c/aspC
metabolites:
  AKG[c] : -ketoglutarate
  PHE[c] : phenylalanine
  GLU[c] : glutamate
  PHPYR[c] : phenylpyruvate

ATP[c] + GLU[c] + NH3[c] -> ADP[c] + PI[c] + GLN[c]
reaction name: "glutamine synthetase glnA1, glnA3, glnA4"
pathway: "Amino acid biosynthesis, Glutamate family, Glutamate/glutamine"
subsystem: Amino acid metabolism
enzymes: Rv2220/glnA1 OR Rv1878/glnA3 OR Rv2860c/glnA4
metabolites:
  ATP[c] : adenosine-triphosphate
  GLU[c] : glutamate
  NH3[c] : ammonia
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  GLN[c] : glutamine

NADH[c] + AKG[c] + GLN[c] <=> NAD[c] + 2 GLU[c]
reaction name: "glutamate synthase gltB, gltD"
pathway: "Amino acid biosynthesis, Glutamate family, Glutamate/glutamine"
subsystem: Amino acid metabolism
enzymes: Rv3859c/gltB AND Rv3858c/gltD
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  AKG[c] : -ketoglutarate
  GLN[c] : glutamine
  NAD[c] : nicotinamide_adenine_dinucleotide
  GLU[c] : glutamate

NADPH[c] + AKG[c] + NH3[c] <=> NADP[c] + GLU[c]
reaction name: glutamate dehydrogenase (NADP)
pathway: "Amino acid biosynthesis, Glutamate family, Glutamate/glutamine"
subsystem: Amino acid metabolism
enzymes: Rv2476c/gdh
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  AKG[c] : -ketoglutarate
  NH3[c] : ammonia
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  GLU[c] : glutamate

ATP[c] + GLU[c] -> ADP[c] + GLUP[c]
reaction name: glutamate 5-kinase proB
pathway: "Amino acid biosynthesis, Glutamate family, Proline"
subsystem: Amino acid metabolism
enzymes: Rv2439c/proB
metabolites:
  ATP[c] : adenosine-triphosphate
  GLU[c] : glutamate
  ADP[c] : adenosine-diphosphate
  GLUP[c] : L-glutamate-5-phosphate

NADPH[c] + GLUP[c] -> PI[c] + NADP[c] + GLUGSAL[c]
reaction name: glutamate-5-semialdehyde dehydrogenase proA
pathway: "Amino acid biosynthesis, Glutamate family, Proline"
subsystem: Amino acid metabolism
enzymes: Rv2427c/proA
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  GLUP[c] : L-glutamate-5-phosphate
  PI[c] : phosphate
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  GLUGSAL[c] : L-glutamate_-semialdehyde

GLUGSAL[c] <=> P5C[c]
reaction name: spontaneous
pathway: "Amino acid biosynthesis, Glutamate family, Proline"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  GLUGSAL[c] : L-glutamate_-semialdehyde
  P5C[c] : pyrroline_5-carboxylate

NADH[c] + NADPH[c] + 2 P5C[c] <=> NAD[c] + NADP[c] + 2 PRO[c]
reaction name: pyrroline-5-carboxylate reductase proC
pathway: "Amino acid biosynthesis, Glutamate family, Proline"
subsystem: Amino acid metabolism
enzymes: Rv0500/proC
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  P5C[c] : pyrroline_5-carboxylate
  NAD[c] : nicotinamide_adenine_dinucleotide
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  PRO[c] : proline

ACCOA[c] + GLU[c] <=> COA[c] + NAGLU[c]
reaction name: "N-acetylglutamate synthase, argA"
pathway: "Amino acid biosynthesis, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv2747/-
metabolites:
  ACCOA[c] : acetyl-CoA
  GLU[c] : glutamate
  COA[c] : coenzyme_A
  NAGLU[c] : N-acetyl-L-glutamate

ATP[c] + NAGLU[c] -> ADP[c] + NAGLUP[c]
reaction name: acetylglutamate kinase
pathway: "Amino acid biosynthesis, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1654/argB
metabolites:
  ATP[c] : adenosine-triphosphate
  NAGLU[c] : N-acetyl-L-glutamate
  ADP[c] : adenosine-diphosphate
  NAGLUP[c] : N-acetylglutamyl-phosphate

NADPH[c] + NAGLUP[c] -> PI[c] + NADP[c] + NAGLUS[c]
reaction name: N-acetyl-gamma-glutamyl-phosphate reductase
pathway: "Amino acid biosynthesis, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1652/argC
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  NAGLUP[c] : N-acetylglutamyl-phosphate
  PI[c] : phosphate
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  NAGLUS[c] : N-acetyl-L-glutamate_5-semialdehyde

GLU[c] + NAGLUS[c] -> AKG[c] + NAORN[c]
reaction name: acetonitrile aminotransferase
pathway: "Amino acid biosynthesis, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1655/argD
metabolites:
  GLU[c] : glutamate
  NAGLUS[c] : N-acetyl-L-glutamate_5-semialdehyde
  AKG[c] : -ketoglutarate
  NAORN[c] : N-acetyl-L-ornithine

GLU[c] + NAORN[c] <=> ORN[c] + NAGLU[c]
reaction name: glutamate N-acetyltransferase
pathway: "Amino acid biosynthesis, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1653/argJ
metabolites:
  GLU[c] : glutamate
  NAORN[c] : N-acetyl-L-ornithine
  ORN[c] : ornithine
  NAGLU[c] : N-acetyl-L-glutamate

2 ATP[c] + CO2[c] + GLN[c] -> 2 ADP[c] + PI[c] + GLU[c] + CAP[c]
reaction name: carbamoyl-phosphate synthase (small chain carA and large chain carB)
pathway: "Amino acid biosynthesis, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1383/carA AND Rv1384/carB
metabolites:
  ATP[c] : adenosine-triphosphate
  CO2[c] : carbon_dioxide
  GLN[c] : glutamine
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  GLU[c] : glutamate
  CAP[c] : carbamoyl-phosphate

ATP[c] + CITR[c] + ASP[c] -> PPI[c] + AMP[c] + ARGSUCC[c]
reaction name: argininosuccinate synthase
pathway: "Amino acid biosynthesis, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1658/argG
metabolites:
  ATP[c] : adenosine-triphosphate
  CITR[c] : citrulline
  ASP[c] : L-aspartate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  ARGSUCC[c] : L-arginino-succinate

ARGSUCC[c] -> FUM[c] + ARG[c]
reaction name: argininosuccinate lyase
pathway: "Amino acid biosynthesis, Glutamate family, Arginine"
subsystem: Amino acid metabolism
enzymes: Rv1659/argH
metabolites:
  ARGSUCC[c] : L-arginino-succinate
  FUM[c] : fumarate
  ARG[c] : L-arginine

2 PYR[c] + 0.001 THI[c] -> CO2[c] + ACLAC[c]
reaction name: "acetolactate synthase, ilvB and ilvN"
pathway: "Amino acid biosynthesis, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv3002c/ilvH AND Rv3003c/ilvB1
metabolites:
  PYR[c] : pyruvate
  THI[c] : thiamine
  CO2[c] : carbon_dioxide
  ACLAC[c] : 2-acetolactate

NADPH[c] + ACLAC[c] -> NADP[c] + DHMVA[c]
reaction name: ketol-acid reductoisomerase ilvC
pathway: "Amino acid biosynthesis, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv3001c/ilvC
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACLAC[c] : 2-acetolactate
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  DHMVA[c] : "2,3-dihydroxy-3-methylvalerate"

DHMVA[c] -> OMVAL[c]
reaction name: dihydroxy-acid dehydratase ilvD
pathway: "Amino acid biosynthesis, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv0189c/ilvD
metabolites:
  DHMVA[c] : "2,3-dihydroxy-3-methylvalerate"
  OMVAL[c] : 2-keto-3-methyl-valerate

GLU[c] + OMVAL[c] <=> AKG[c] + VAL[c]
reaction name: branched-chain-amino-acid transaminase ilvE
pathway: "Amino acid biosynthesis, Branched chain amino acids, Valine"
subsystem: Amino acid metabolism
enzymes: Rv2210c/ilvE
metabolites:
  GLU[c] : glutamate
  OMVAL[c] : 2-keto-3-methyl-valerate
  AKG[c] : -ketoglutarate
  VAL[c] : valine

THR[c] -> NH3[c] + OBUT[c]
reaction name: threonine ammonia-lyase
pathway: "Amino acid biosynthesis, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv1559/ilvA
metabolites:
  THR[c] : threonine
  NH3[c] : ammonia
  OBUT[c] : 2-oxobutanoate

PYR[c] + OBUT[c] -> CO2[c] + ABUT[c]
reaction name: "acetolactate synthase ilvX, ilvG, ilvB1, ilvB2"
pathway: "Amino acid biosynthesis, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv3509c/ilvX OR Rv1820/ilvG OR Rv3003c/ilvB1 OR Rv3470c/ilvB2 AND Rv3002c/ilvH
metabolites:
  PYR[c] : pyruvate
  OBUT[c] : 2-oxobutanoate
  CO2[c] : carbon_dioxide
  ABUT[c] : 2-aceto-2-hydroxy-butyrate

NADPH[c] + ABUT[c] -> NADP[c] + DIHYDROXYMETHYLPENTANOATE[c]
reaction name: ketol-acid reductoisomerase
pathway: "Amino acid biosynthesis, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv3001c/ilvC
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ABUT[c] : 2-aceto-2-hydroxy-butyrate
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  DIHYDROXYMETHYLPENTANOATE[c] : Dihydroxy-methylpentanoate

DIHYDROXYMETHYLPENTANOATE[c] -> OXOMETHYLPENTANOATE[c]
reaction name: dihydroxy-acid dehydratase
pathway: "Amino acid biosynthesis, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv0189c/ilvD
metabolites:
  DIHYDROXYMETHYLPENTANOATE[c] : Dihydroxy-methylpentanoate
  OXOMETHYLPENTANOATE[c] : 2-oxo-3-methylpentanoate

GLU[c] + OXOMETHYLPENTANOATE[c] <=> AKG[c] + ILE[c]
reaction name: branched-chain-amino-acid transaminase
pathway: "Amino acid biosynthesis, Branched chain amino acids, Isoleucine"
subsystem: Amino acid metabolism
enzymes: Rv2210c/ilvE
metabolites:
  GLU[c] : glutamate
  OXOMETHYLPENTANOATE[c] : 2-oxo-3-methylpentanoate
  AKG[c] : -ketoglutarate
  ILE[c] : L-isoleucine

ACCOA[c] + OMVAL[c] -> COA[c] + IPPMAL[c]
reaction name: 2-isopropylmalate synthase leuA
pathway: "Amino acid biosynthesis, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv3710/leuA
metabolites:
  ACCOA[c] : acetyl-CoA
  OMVAL[c] : 2-keto-3-methyl-valerate
  COA[c] : coenzyme_A
  IPPMAL[c] : 2-isopropylmalate

IPPMAL[c] <=> CBHCAP[c]
reaction name: 3-isopropylmalate dehydratase (large subunit leuC AND small subunit leuD)
pathway: "Amino acid biosynthesis, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv2988c/leuC AND Rv2987c/leuD
metabolites:
  IPPMAL[c] : 2-isopropylmalate
  CBHCAP[c] : 3-carboxy-2-hydroxy-4-methylpentanoate

NAD[c] + CBHCAP[c] -> NADH[c] + OICAP[c]
reaction name: 3-isopropylmalate dehydrogenase
pathway: "Amino acid biosynthesis, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv2995c/leuB
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  CBHCAP[c] : 3-carboxy-2-hydroxy-4-methylpentanoate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  OICAP[c] : oicap

OICAP[c] -> CO2[c] + MOP[c]
reaction name: spontaneous
pathway: "Amino acid biosynthesis, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  OICAP[c] : oicap
  CO2[c] : carbon_dioxide
  MOP[c] : 4-methyl-2-oxopentanoate

GLU[c] + MOP[c] <=> AKG[c] + LEU[c]
reaction name: branched-chain-amino-acid transaminase
pathway: "Amino acid biosynthesis, Branched chain amino acids, Leucine"
subsystem: Amino acid metabolism
enzymes: Rv2210c/ilvE
metabolites:
  GLU[c] : glutamate
  MOP[c] : 4-methyl-2-oxopentanoate
  AKG[c] : -ketoglutarate
  LEU[c] : L-leucine

OA[c] + GLU[c] <=> AKG[c] + ASP[c]
reaction name: "aspartate transaminase aspB, aspC"
pathway: "Amino acid biosynthesis, The aspartate family, Aspartate"
subsystem: Amino acid metabolism
enzymes: Rv3565/aspB OR Rv0337c/aspC
metabolites:
  OA[c] : oxaloacetate
  GLU[c] : glutamate
  AKG[c] : -ketoglutarate
  ASP[c] : L-aspartate

ATP[c] + ASP[c] + GLN[c] -> PPI[c] + AMP[c] + GLU[c] + ASN[c]
reaction name: asparagine synthase asnB
pathway: "Amino acid biosynthesis, The aspartate family, Asparagine"
subsystem: Amino acid metabolism
enzymes: Rv2201/asnB
metabolites:
  ATP[c] : adenosine-triphosphate
  ASP[c] : L-aspartate
  GLN[c] : glutamine
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  GLU[c] : glutamate
  ASN[c] : L-asparagine

ATP[c] + ASP[c] -> ADP[c] + ASP4P[c]
reaction name: aspartate kinase ask
pathway: "Amino acid biosynthesis, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: Rv3709c/ask
metabolites:
  ATP[c] : adenosine-triphosphate
  ASP[c] : L-aspartate
  ADP[c] : adenosine-diphosphate
  ASP4P[c] : L-aspartyl-4-phosphate

NADPH[c] + ASP4P[c] -> PI[c] + NADP[c] + ASPSA[c]
reaction name: aspartate-semialdehyde dehydrogenase asd
pathway: "Amino acid biosynthesis, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: Rv3708c/asd
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ASP4P[c] : L-aspartyl-4-phosphate
  PI[c] : phosphate
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  ASPSA[c] : L-aspartate-semialdehyde

NADPH[c] + ASPSA[c] -> NADP[c] + HSER[c]
reaction name: homoserine dehydrogenase thrA
pathway: "Amino acid biosynthesis, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: Rv1294/thrA
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ASPSA[c] : L-aspartate-semialdehyde
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  HSER[c] : homoserine

ATP[c] + HSER[c] -> ADP[c] + PHSER[c]
reaction name: homoserine kinase thrB
pathway: "Amino acid biosynthesis, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: Rv1296/thrB
metabolites:
  ATP[c] : adenosine-triphosphate
  HSER[c] : homoserine
  ADP[c] : adenosine-diphosphate
  PHSER[c] : o-phospho-l-homoserine

PHSER[c] -> PI[c] + THR[c]
reaction name: threonine synthase thrC
pathway: "Amino acid biosynthesis, The aspartate family, Threonine"
subsystem: Amino acid metabolism
enzymes: Rv1295/thrC
metabolites:
  PHSER[c] : o-phospho-l-homoserine
  PI[c] : phosphate
  THR[c] : threonine

PYR[c] + ASPSA[c] -> DIHYDRODIPICOLINATE[c]
reaction name: dihydrodipicolinate synthase dapA
pathway: "Amino acid biosynthesis, The aspartate family, Lysine"
subsystem: Amino acid metabolism
enzymes: Rv2753c/dapA
metabolites:
  PYR[c] : pyruvate
  ASPSA[c] : L-aspartate-semialdehyde
  DIHYDRODIPICOLINATE[c] : "L-2,3-dihydrodipicolinate"

NADH[c] + NADPH[c] + 2 DIHYDRODIPICOLINATE[c] -> NAD[c] + NADP[c] + 2 TETRAHYDRODIPICOLINATE[c]
reaction name: dihydrodipicolinate reductase dapB
pathway: "Amino acid biosynthesis, The aspartate family, Lysine"
subsystem: Amino acid metabolism
enzymes: Rv2773c/dapB
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  DIHYDRODIPICOLINATE[c] : "L-2,3-dihydrodipicolinate"
  NAD[c] : nicotinamide_adenine_dinucleotide
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  TETRAHYDRODIPICOLINATE[c] : tetrahydrodipicolinate

SUCCOA[c] + TETRAHYDRODIPICOLINATE[c] -> COA[c] + SAOPIM[c]
reaction name: "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase"
pathway: "Amino acid biosynthesis, The aspartate family, Lysine"
subsystem: Amino acid metabolism
enzymes: Rv1201c/-
metabolites:
  SUCCOA[c] : succinyl-CoA
  TETRAHYDRODIPICOLINATE[c] : tetrahydrodipicolinate
  COA[c] : coenzyme_A
  SAOPIM[c] : N-succinyl-2-amino-6-ketopimelate

GLU[c] + SAOPIM[c] <=> AKG[c] + SDAPIM[c]
reaction name: succinyldiaminopimelate transaminase argD
pathway: "Amino acid biosynthesis, The aspartate family, Lysine"
subsystem: Amino acid metabolism
enzymes: Rv1655/argD OR Rv0858c/-
metabolites:
  GLU[c] : glutamate
  SAOPIM[c] : N-succinyl-2-amino-6-ketopimelate
  AKG[c] : -ketoglutarate
  SDAPIM[c] : "N-succinyl-L,L-2,6-diaminopimelate"

SDAPIM[c] -> SUCC[c] + DAPIM[c]
reaction name: succinyl-diaminopimelate desuccinylase dapE
pathway: "Amino acid biosynthesis, The aspartate family, Lysine"
subsystem: Amino acid metabolism
enzymes: Rv1202/dapE
metabolites:
  SDAPIM[c] : "N-succinyl-L,L-2,6-diaminopimelate"
  SUCC[c] : succinate
  DAPIM[c] : "L,L-diaminopimelate"

DAPIM[c] <=> MDAPIM[c]
reaction name: diaminopimelate epimerase dapF
pathway: "Amino acid biosynthesis, The aspartate family, Lysine"
subsystem: Amino acid metabolism
enzymes: Rv2726c/dapF
metabolites:
  DAPIM[c] : "L,L-diaminopimelate"
  MDAPIM[c] : meso-diaminopimelate

MDAPIM[c] -> CO2[c] + LYS[c]
reaction name: diaminopimelate decarboxylase lysA
pathway: "Amino acid biosynthesis, The aspartate family, Lysine"
subsystem: Amino acid metabolism
enzymes: Rv1293/lysA
metabolites:
  MDAPIM[c] : meso-diaminopimelate
  CO2[c] : carbon_dioxide
  LYS[c] : L-lysine

SUCCOA[c] + HSER[c] <=> COA[c] + OSLHSER[c]
reaction name: homoserine O-succinyltransferase
pathway: "Amino acid biosynthesis, The aspartate family, Methionine"
subsystem: Amino acid metabolism
enzymes: orphan
metabolites:
  SUCCOA[c] : succinyl-CoA
  HSER[c] : homoserine
  COA[c] : coenzyme_A
  OSLHSER[c] : O-succinyl-L-homoserine

CYS[c] + OSLHSER[c] -> SUCC[c] + LLCT[c]
reaction name: cystathionine gamma-synthase metB
pathway: "Amino acid biosynthesis, The aspartate family, Methionine"
subsystem: Amino acid metabolism
enzymes: Rv1079/metB
metabolites:
  CYS[c] : L-cysteine
  OSLHSER[c] : O-succinyl-L-homoserine
  SUCC[c] : succinate
  LLCT[c] : cystathionine

LLCT[c] -> PYR[c] + NH3[c] + HCYS[c]
reaction name: cystathionine beta-lyase
pathway: "Amino acid biosynthesis, The aspartate family, Methionine"
subsystem: Amino acid metabolism
enzymes: Rv3340/metC
metabolites:
  LLCT[c] : cystathionine
  PYR[c] : pyruvate
  NH3[c] : ammonia
  HCYS[c] : L-homocysteine

SAM[c] + HCYS[c] -> MET[c] + SAH[c]
reaction name: Probable Homocysteine S-Methyltransferase mmuM
pathway: "Amino acid biosynthesis, The aspartate family, Methionine"
subsystem: Amino acid metabolism
enzymes: Rv2458/mmuM
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  HCYS[c] : L-homocysteine
  MET[c] : methionine
  SAH[c] : S-adenosyl-L-homocysteine

MTHF[c] + HCYS[c] + 0.002 COB[I][c] -> THF[c] + MET[c] + 0.001 COB_II[c]
reaction name: methionine synthase (cobalamin-dependent) metH
pathway: "Amino acid biosynthesis, The aspartate family, Methionine"
subsystem: Amino acid metabolism
enzymes: Rv2124c/metH
metabolites:
  MTHF[c] : 5-methyl-THF
  HCYS[c] : L-homocysteine
  COB[I][c] : coenzyme B12
  THF[c] : tetrahydrofolate
  MET[c] : methionine
  COB_II[c] : COB-II

THF[c] + MET[c] + 0.002 COB[I][c] -> MTHF[c] + HCYS[c] + 0.001 COB_II[c]
reaction name: methionine synthase (cobalamin-dependent) metH
pathway: "Amino acid biosynthesis, The aspartate family, Methionine"
subsystem: Amino acid metabolism
enzymes: Rv2124c/metH
metabolites:
  THF[c] : tetrahydrofolate
  MET[c] : methionine
  COB[I][c] : coenzyme B12
  MTHF[c] : 5-methyl-THF
  HCYS[c] : L-homocysteine
  COB_II[c] : COB-II

MTHF[c] + HCYS[c] <=> THF[c] + MET[c]
reaction name: methionine synthase (cobalamin-independent) metE
pathway: "Amino acid biosynthesis, The aspartate family, Methionine"
subsystem: Amino acid metabolism
enzymes: Rv1133c/metE
metabolites:
  MTHF[c] : 5-methyl-THF
  HCYS[c] : L-homocysteine
  THF[c] : tetrahydrofolate
  MET[c] : methionine

NADH[c] + PYR[c] + NH3[c] <=> NAD[c] + ALA[c]
reaction name: alanine dehydrogenase
pathway: "Amino acid biosynthesis, The pyruvate family, alanine"
subsystem: Amino acid metabolism
enzymes: Rv2780/ald
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  PYR[c] : pyruvate
  NH3[c] : ammonia
  NAD[c] : nicotinamide_adenine_dinucleotide
  ALA[c] : D-alanine

NAD[c] + 3PG[c] -> NADH[c] + PHP[c]
reaction name: phosphoglycerate dehydrogenase
pathway: "Amino acid biosynthesis, The serine family, Serine"
subsystem: Amino acid metabolism
enzymes: Rv2996c/serA1
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  3PG[c] : 3-phosphoglycerate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  PHP[c] : 3-phospho-hydroxypyruvate

GLU[c] + PHP[c] <=> AKG[c] + 3PSER[c]
reaction name: phosphoserine transaminase
pathway: "Amino acid biosynthesis, The serine family, Serine"
subsystem: Amino acid metabolism
enzymes: Rv0884c/serC
metabolites:
  GLU[c] : glutamate
  PHP[c] : 3-phospho-hydroxypyruvate
  AKG[c] : -ketoglutarate
  3PSER[c] : 3-phospho-serine

3PSER[c] -> PI[c] + SER[c]
reaction name: phosphoserine phosphatase
pathway: "Amino acid biosynthesis, The serine family, Serine"
subsystem: Amino acid metabolism
enzymes: Rv3042c/serB2
metabolites:
  3PSER[c] : 3-phospho-serine
  PI[c] : phosphate
  SER[c] : serine

ACCOA[c] + SER[c] <=> COA[c] + ASER[c]
reaction name: serine O-acetyltransferase
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv2335/cysE
metabolites:
  ACCOA[c] : acetyl-CoA
  SER[c] : serine
  COA[c] : coenzyme_A
  ASER[c] : O-acetyl-L-serine

H2S[c] + ASER[c] -> AC[c] + CYS[c]
reaction name: "cysteine synthase cysK, cysM"
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv2334/cysK1 OR Rv1336/cysM
metabolites:
  H2S[c] : hydrogen_sulfide
  ASER[c] : O-acetyl-L-serine
  AC[c] : acetate
  CYS[c] : L-cysteine

ACCOA[c] + HSER[c] <=> COA[c] + OAHSER[c]
reaction name: homoserine O-acetyltransferase metA
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv3341/metX
metabolites:
  ACCOA[c] : acetyl-CoA
  HSER[c] : homoserine
  COA[c] : coenzyme_A
  OAHSER[c] : O-acetyl-L-homoserine

CYS[c] + OAHSER[c] -> AC[c] + LLCT[c]
reaction name: cystathionine gamma-synthase metB
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv1079/metB
metabolites:
  CYS[c] : L-cysteine
  OAHSER[c] : O-acetyl-L-homoserine
  AC[c] : acetate
  LLCT[c] : cystathionine

H2S[c] + OAHSER[c] -> AC[c] + HCYS[c]
reaction name: cystathionine gamma-synthase metB
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv1079/metB
metabolites:
  H2S[c] : hydrogen_sulfide
  OAHSER[c] : O-acetyl-L-homoserine
  AC[c] : acetate
  HCYS[c] : L-homocysteine

H2S[c] + OSLHSER[c] -> SUCC[c] + HCYS[c]
reaction name: cystathionine gamma-synthase metB
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv1079/metB
metabolites:
  H2S[c] : hydrogen_sulfide
  OSLHSER[c] : O-succinyl-L-homoserine
  SUCC[c] : succinate
  HCYS[c] : L-homocysteine

OSLHSER[c] -> SUCC[c] + NH3[c] + OBUT[c]
reaction name: cystathionine gamma-synthase metB
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv1079/metB
metabolites:
  OSLHSER[c] : O-succinyl-L-homoserine
  SUCC[c] : succinate
  NH3[c] : ammonia
  OBUT[c] : 2-oxobutanoate

SER[c] + HCYS[c] -> LLCT[c]
reaction name: cystathionine beta-synthase cysM2
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv1077/cbs
metabolites:
  SER[c] : serine
  HCYS[c] : L-homocysteine
  LLCT[c] : cystathionine

LLCT[c] -> NH3[c] + OBUT[c] + CYS[c]
reaction name: cystathionine gamma-lyase
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv1079/metB
metabolites:
  LLCT[c] : cystathionine
  NH3[c] : ammonia
  OBUT[c] : 2-oxobutanoate
  CYS[c] : L-cysteine

ATP[c] + MET[c] -> PI[c] + PPI[c] + SAM[c]
reaction name: s-adenosylmethionine synthetase
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv1392/metK
metabolites:
  ATP[c] : adenosine-triphosphate
  MET[c] : methionine
  PI[c] : phosphate
  PPI[c] : pyrophosphate
  SAM[c] : S-adenosyl-L-methionine

SAH[c] -> HCYS[c] + ADN[c]
reaction name: S-adenosylhomocysteine hydrolase
pathway: "Amino acid biosynthesis, The serine family, Cysteine"
subsystem: Amino acid metabolism
enzymes: Rv3248c/sahH
metabolites:
  SAH[c] : S-adenosyl-L-homocysteine
  HCYS[c] : L-homocysteine
  ADN[c] : adenosine

ATP[c] + PRPP[c] -> PPI[c] + PRBATP[c]
reaction name: ATP phosphoribosyltransferase
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv2121c/hisG
metabolites:
  ATP[c] : adenosine-triphosphate
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  PPI[c] : pyrophosphate
  PRBATP[c] : 5-phosphoribosyl_1-pyrophosphate

PRBATP[c] -> PPI[c] + PRBAMP[c]
reaction name: phosphoribosyl-ATP diphosphatase
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv2122c/hisE
metabolites:
  PRBATP[c] : 5-phosphoribosyl_1-pyrophosphate
  PPI[c] : pyrophosphate
  PRBAMP[c] : phosphoribosylformiminoAICAR-phosphate

PRBAMP[c] -> PRFP[c]
reaction name: phosphoribosyl-AMP cyclohydrolase
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv1606/hisI
metabolites:
  PRBAMP[c] : phosphoribosylformiminoAICAR-phosphate
  PRFP[c] : phosphoribosylformiminoAICAR-phosphate

PRFP[c] -> PRLP[c]
reaction name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv1603/hisA
metabolites:
  PRFP[c] : phosphoribosylformiminoAICAR-phosphate
  PRLP[c] : phosphoribulosylformimino-AICAR-P

GLN[c] + PRLP[c] -> GLU[c] + AICAR[c] + DIMGP[c]
reaction name: amidotransferase
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv1602/hisH
metabolites:
  GLN[c] : glutamine
  PRLP[c] : phosphoribulosylformimino-AICAR-P
  GLU[c] : glutamate
  AICAR[c] : amino-4-imidazolecarboxamide_ribotide
  DIMGP[c] : D-erythro-imidazole-glycerol-phosphate

DIMGP[c] -> IMACP[c]
reaction name: imidazole glycerol-phosphate dehydratase
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv1601/hisB
metabolites:
  DIMGP[c] : D-erythro-imidazole-glycerol-phosphate
  IMACP[c] : imidazole_acetol-phosphate

GLU[c] + IMACP[c] <=> AKG[c] + HISOLP[c]
reaction name: "histidinol-phosphate transaminase hisC, hisC2"
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv3772/hisC2 OR Rv1600/hisC1
metabolites:
  GLU[c] : glutamate
  IMACP[c] : imidazole_acetol-phosphate
  AKG[c] : -ketoglutarate
  HISOLP[c] : L-histidinol-phosphate

HISOLP[c] -> PI[c] + HISOL[c]
reaction name: histidinol-phosphatase
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv1601/hisB
metabolites:
  HISOLP[c] : L-histidinol-phosphate
  PI[c] : phosphate
  HISOL[c] : histidinol

2 NAD[c] + HISOL[c] -> 2 NADH[c] + HIS[c]
reaction name: histidinol dehydrogenase hisD
pathway: "Amino acid biosynthesis, The histidine family, Histidine"
subsystem: Amino acid metabolism
enzymes: Rv1599/hisD
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  HISOL[c] : histidinol
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  HIS[c] : L-histidine

PEP[c] + E4P[c] -> PI[c] + 3DDAH7P[c]
reaction name: 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase aroG
pathway: "Amino acid biosynthesis, The aromatic family, The shikimate pathway"
subsystem: Amino acid metabolism
enzymes: Rv2178c/aroG
metabolites:
  PEP[c] : phosphoenolpyruvate
  E4P[c] : D-erythrose-4-phosphate
  PI[c] : phosphate
  3DDAH7P[c] : 3-deoxy-D-arabino-heptulosonate-7-phosphate

3DDAH7P[c] -> PI[c] + DQT[c]
reaction name: 3-dehydroquinate synthase
pathway: "Amino acid biosynthesis, The aromatic family, The shikimate pathway"
subsystem: Amino acid metabolism
enzymes: Rv2538c/aroB
metabolites:
  3DDAH7P[c] : 3-deoxy-D-arabino-heptulosonate-7-phosphate
  PI[c] : phosphate
  DQT[c] : 3-dehydroquinate

DQT[c] -> DHSK[c]
reaction name: 3-dehydroquinate dehydratase
pathway: "Amino acid biosynthesis, The aromatic family, The shikimate pathway"
subsystem: Amino acid metabolism
enzymes: Rv2537c/aroD
metabolites:
  DQT[c] : 3-dehydroquinate
  DHSK[c] : 3-dehydro-shikimate

NADPH[c] + DHSK[c] -> NADP[c] + SME[c]
reaction name: shikimate dehydrogenase
pathway: "Amino acid biosynthesis, The aromatic family, The shikimate pathway"
subsystem: Amino acid metabolism
enzymes: Rv2552c/aroE
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  DHSK[c] : 3-dehydro-shikimate
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  SME[c] : shikimate

ATP[c] + SME[c] -> ADP[c] + SME3P[c]
reaction name: shikimate kinase
pathway: "Amino acid biosynthesis, The aromatic family, The shikimate pathway"
subsystem: Amino acid metabolism
enzymes: Rv2539c/aroK
metabolites:
  ATP[c] : adenosine-triphosphate
  SME[c] : shikimate
  ADP[c] : adenosine-diphosphate
  SME3P[c] : shikimate-3-phosphate

PEP[c] + SME3P[c] -> PI[c] + 3PSME[c]
reaction name: 3-phosphoshikimate 1-carboxyvinyltransferase
pathway: "Amino acid biosynthesis, The aromatic family, The shikimate pathway"
subsystem: Amino acid metabolism
enzymes: Rv3227/aroA
metabolites:
  PEP[c] : phosphoenolpyruvate
  SME3P[c] : shikimate-3-phosphate
  PI[c] : phosphate
  3PSME[c] : 5-enolpyruvyl-shikimate-3-phosphate

3PSME[c] -> PI[c] + CHOR[c]
reaction name: chorismate synthase
pathway: "Amino acid biosynthesis, The aromatic family, The shikimate pathway"
subsystem: Amino acid metabolism
enzymes: Rv2540c/aroF
metabolites:
  3PSME[c] : 5-enolpyruvyl-shikimate-3-phosphate
  PI[c] : phosphate
  CHOR[c] : chorismate

GLN[c] + CHOR[c] -> PYR[c] + GLU[c] + AN[c]
reaction name: "anthranilate synthase trpE, trpG"
pathway: "Amino acid biosynthesis, The aromatic family, Tryptophan biosynthesis"
subsystem: Amino acid metabolism
enzymes: Rv1609/trpE
metabolites:
  GLN[c] : glutamine
  CHOR[c] : chorismate
  PYR[c] : pyruvate
  GLU[c] : glutamate
  AN[c] : anthranilate

PRPP[c] + AN[c] -> PPI[c] + NPRAN[c]
reaction name: anthranilate phosphoribosyltransferase trpD
pathway: "Amino acid biosynthesis, The aromatic family, Tryptophan biosynthesis"
subsystem: Amino acid metabolism
enzymes: Rv2192c/trpD
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  AN[c] : anthranilate
  PPI[c] : pyrophosphate
  NPRAN[c] : N-(5-phosphoribosyl)-anthranilate

NPRAN[c] -> CPAD5P[c]
reaction name: phosphoribosylanthranilate isomerase
pathway: "Amino acid biosynthesis, The aromatic family, Tryptophan biosynthesis"
subsystem: Amino acid metabolism
enzymes: Rv1603/hisA
metabolites:
  NPRAN[c] : N-(5-phosphoribosyl)-anthranilate
  CPAD5P[c] : 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate

CPAD5P[c] -> CO2[c] + IGP[c]
reaction name: indole-3-glycerol-phosphate synthase trpC
pathway: "Amino acid biosynthesis, The aromatic family, Tryptophan biosynthesis"
subsystem: Amino acid metabolism
enzymes: Rv1611/trpC
metabolites:
  CPAD5P[c] : 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate
  CO2[c] : carbon_dioxide
  IGP[c] : indole-3-glycerol-phosphate

SER[c] + IGP[c] -> G3P[c] + TRP[c]
reaction name: "tryptophan synthase trpA, trpB"
pathway: "Amino acid biosynthesis, The aromatic family, Tryptophan biosynthesis"
subsystem: Amino acid metabolism
enzymes: Rv1613/trpA AND Rv1612/trpB
metabolites:
  SER[c] : serine
  IGP[c] : indole-3-glycerol-phosphate
  G3P[c] : D-glyceraldehyde-3-phosphate
  TRP[c] : tryptophan

CHOR[c] <=> PHEN[c]
reaction name: chorismate mutase
pathway: "Amino acid biosynthesis, The aromatic family, Tyrosine and phenylalanine"
subsystem: Amino acid metabolism
enzymes: Rv1885c/- OR Rv0948c/-
metabolites:
  CHOR[c] : chorismate
  PHEN[c] : prephenate

PHEN[c] -> CO2[c] + PHPYR[c]
reaction name: prephenate dehydratase
pathway: "Amino acid biosynthesis, The aromatic family, Tyrosine and phenylalanine"
subsystem: Amino acid metabolism
enzymes: Rv3838c/pheA
metabolites:
  PHEN[c] : prephenate
  CO2[c] : carbon_dioxide
  PHPYR[c] : phenylpyruvate

GLU[c] + PHPYR[c] <=> AKG[c] + PHE[c]
reaction name: aspartate transaminase
pathway: "Amino acid biosynthesis, The aromatic family, Tyrosine and phenylalanine"
subsystem: Amino acid metabolism
enzymes: Rv3565/aspB OR Rv0337c/aspC
metabolites:
  GLU[c] : glutamate
  PHPYR[c] : phenylpyruvate
  AKG[c] : -ketoglutarate
  PHE[c] : phenylalanine

NAD[c] + PHEN[c] -> NADH[c] + CO2[c] + 4HPP[c]
reaction name: prephenate dehydrogenase tyrA
pathway: "Amino acid biosynthesis, The aromatic family, Tyrosine and phenylalanine"
subsystem: Amino acid metabolism
enzymes: Rv3754/tyrA
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  PHEN[c] : prephenate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  CO2[c] : carbon_dioxide
  4HPP[c] : p-hydroxyphenylpyruvate

GLU[c] + 4HPP[c] <=> AKG[c] + TYR[c]
reaction name: aspartate transaminase aspB
pathway: "Amino acid biosynthesis, The aromatic family, Tyrosine and phenylalanine"
subsystem: Amino acid metabolism
enzymes: Rv3565/aspB OR Rv0337c/aspC
metabolites:
  GLU[c] : glutamate
  4HPP[c] : p-hydroxyphenylpyruvate
  AKG[c] : -ketoglutarate
  TYR[c] : tyrosine

ATP[c] + R5P[c] <=> AMP[c] + PRPP[c]
reaction name: ribose-phosphate diphosphokinase
pathway: Nucleotide biosynthesis
subsystem: Nucleotide biosynthesis
enzymes: Rv1017c/prsA
metabolites:
  ATP[c] : adenosine-triphosphate
  R5P[c] : D-ribose-5-phosphate
  AMP[c] : adenosine-monophosphate
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate

CAP[c] + ASP[c] -> PI[c] + CAASP[c]
reaction name: aspartate carbamoyltransferase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv1380/pyrB
metabolites:
  CAP[c] : carbamoyl-phosphate
  ASP[c] : L-aspartate
  PI[c] : phosphate
  CAASP[c] : carbamoyl-L-aspartate

CAASP[c] <=> DOROA[c]
reaction name: dihydroorotase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv1381/pyrC
metabolites:
  CAASP[c] : carbamoyl-L-aspartate
  DOROA[c] : dihydroorotate

O2[c] + DOROA[c] -> H2O2[c] + OROA[c]
reaction name: dihydroorotate oxidase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv2139/pyrD
metabolites:
  O2[c] : oxygen
  DOROA[c] : dihydroorotate
  H2O2[c] : hydrogen_peroxide
  OROA[c] : orotate

PRPP[c] + OROA[c] -> PPI[c] + OMP[c]
reaction name: orotate phosphoribosyltransferase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv0382c/pyrE
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  OROA[c] : orotate
  PPI[c] : pyrophosphate
  OMP[c] : orotidine-5-phosphate

OMP[c] -> CO2[c] + UMP[c]
reaction name: orotidine-5-phosphate decarboxylase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv1385/pyrF
metabolites:
  OMP[c] : orotidine-5-phosphate
  CO2[c] : carbon_dioxide
  UMP[c] : uridine-monophosphate

ATP[c] + UMP[c] <=> ADP[c] + UDP[c]
reaction name: cytidylate kinase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv1712/cmk
metabolites:
  ATP[c] : adenosine-triphosphate
  UMP[c] : uridine-monophosphate
  ADP[c] : adenosine-diphosphate
  UDP[c] : uridine-diphosphate

ATP[c] + UDP[c] <=> ADP[c] + UTP[c]
reaction name: nucleoside-diphosphate kinase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv2445c/ndk
metabolites:
  ATP[c] : adenosine-triphosphate
  UDP[c] : uridine-diphosphate
  ADP[c] : adenosine-diphosphate
  UTP[c] : uridine-triphosphate

ATP[c] + UTP[c] + GLN[c] -> ADP[c] + PI[c] + GLU[c] + CTP[c]
reaction name: CTP synthase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv1699/pyrG
metabolites:
  ATP[c] : adenosine-triphosphate
  UTP[c] : uridine-triphosphate
  GLN[c] : glutamine
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  GLU[c] : glutamate
  CTP[c] : cytidine-5-triphosphate

ATP[c] + UTP[c] + NH3[c] -> ADP[c] + PI[c] + CTP[c]
reaction name: CTP synthase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv1699/pyrG
metabolites:
  ATP[c] : adenosine-triphosphate
  UTP[c] : uridine-triphosphate
  NH3[c] : ammonia
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  CTP[c] : cytidine-5-triphosphate

O2[c] + RTHIO[c] + CDP[c] -> OTHIO[c] + DCDP[c]
reaction name: "ribonucleoside-diphosphate reductase, nrdE and nrdF2"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv3051c/nrdE AND Rv3048c/nrdF
metabolites:
  O2[c] : oxygen
  RTHIO[c] : reduced_thioredoxin
  CDP[c] : cytidine-diphosphate
  OTHIO[c] : thioredoxin_disulfide
  DCDP[c] : deoxycytidine-diphosphate

RTHIO[c] + COB_II[c] + CDP[c] -> OTHIO[c] + COB_III[c] + DCDP[c]
reaction name: "ribonucleoside-diphosphate reductase, nrdZ"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv0570/nrdZ
metabolites:
  RTHIO[c] : reduced_thioredoxin
  COB_II[c] : COB-II
  CDP[c] : cytidine-diphosphate
  OTHIO[c] : thioredoxin_disulfide
  COB_III[c] : COB-III
  DCDP[c] : deoxycytidine-diphosphate

ATP[c] + DCDP[c] -> ADP[c] + DCTP[c]
reaction name: nucleoside-diphosphate kinase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv2445c/ndk
metabolites:
  ATP[c] : adenosine-triphosphate
  DCDP[c] : deoxycytidine-diphosphate
  ADP[c] : adenosine-diphosphate
  DCTP[c] : deoxycytidine-triphosphate

DCTP[c] -> NH3[c] + DUTP[c]
reaction name: dCTP deaminase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine deoxyribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv0321/dcd
metabolites:
  DCTP[c] : deoxycytidine-triphosphate
  NH3[c] : ammonia
  DUTP[c] : deoxyuridine-triphosphate

DUTP[c] -> PPI[c] + DUMP[c]
reaction name: dUTP diphosphatase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine deoxyribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv2697c/dut
metabolites:
  DUTP[c] : deoxyuridine-triphosphate
  PPI[c] : pyrophosphate
  DUMP[c] : deoxyuridine-phosphate

METTHF[c] + FADH2[c] + DUMP[c] <=> FAD[c] + THF[c] + DTMP[c]
reaction name: "thymidylate synthase, thyX"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine deoxyribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv2754c/thyX
metabolites:
  METTHF[c] : "5,10-methylene-THF"
  FADH2[c] : flavin adenine dinucleotide reduced
  DUMP[c] : deoxyuridine-phosphate
  FAD[c] : flavin adenine dinucleotide
  THF[c] : tetrahydrofolate
  DTMP[c] : deoxythymidine 5-phosphate

METTHF[c] + DUMP[c] <=> DTMP[c] + DHF[c]
reaction name: "thymidylate synthase, thyA"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine deoxyribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv2764c/thyA
metabolites:
  METTHF[c] : "5,10-methylene-THF"
  DUMP[c] : deoxyuridine-phosphate
  DTMP[c] : deoxythymidine 5-phosphate
  DHF[c] : "7,8-dihydrofolate"

ATP[c] + DTMP[c] <=> ADP[c] + DTDP[c]
reaction name: dTMP kinase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine deoxyribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv3247c/tmk
metabolites:
  ATP[c] : adenosine-triphosphate
  DTMP[c] : deoxythymidine 5-phosphate
  ADP[c] : adenosine-diphosphate
  DTDP[c] : deoxythymidine-5-diphosphate

ATP[c] + DTDP[c] <=> ADP[c] + DTTP[c]
reaction name: nucleoside-diphosphate kinase
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine deoxyribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv2445c/ndk
metabolites:
  ATP[c] : adenosine-triphosphate
  DTDP[c] : deoxythymidine-5-diphosphate
  ADP[c] : adenosine-diphosphate
  DTTP[c] : deoxythymidine 5-triphosphate

ATP[c] + CDP[c] <=> ADP[c] + CTP[c]
reaction name: nucleoside-diphosphate kinase
pathway: "Nucleotide biosynthesis, Pyrimidines"
subsystem: Nucleotide biosynthesis
enzymes: Rv2445c/ndk
metabolites:
  ATP[c] : adenosine-triphosphate
  CDP[c] : cytidine-diphosphate
  ADP[c] : adenosine-diphosphate
  CTP[c] : cytidine-5-triphosphate

ATP[c] + CMP[c] <=> ADP[c] + CDP[c]
reaction name: cytidylate kinase
pathway: "Nucleotide biosynthesis, Pyrimidines"
subsystem: Nucleotide biosynthesis
enzymes: Rv1712/cmk
metabolites:
  ATP[c] : adenosine-triphosphate
  CMP[c] : cytidine-monophosphate
  ADP[c] : adenosine-diphosphate
  CDP[c] : cytidine-diphosphate

DCTP[c] -> PPI[c] + DCMP[c]
reaction name: dCTP pyrophosphatase
pathway: "Nucleotide biosynthesis, Pyrimidines"
subsystem: Nucleotide biosynthesis
enzymes: orphan
metabolites:
  DCTP[c] : deoxycytidine-triphosphate
  PPI[c] : pyrophosphate
  DCMP[c] : deoxycytidine_monophosphate

ATP[c] + DCMP[c] <=> ADP[c] + DCDP[c]
reaction name: cytidylate kinase
pathway: "Nucleotide biosynthesis, Pyrimidines"
subsystem: Nucleotide biosynthesis
enzymes: Rv1712/cmk
metabolites:
  ATP[c] : adenosine-triphosphate
  DCMP[c] : deoxycytidine_monophosphate
  ADP[c] : adenosine-diphosphate
  DCDP[c] : deoxycytidine-diphosphate

NADPH[c] + OTHIO[c] -> NAD[c] + RTHIO[c]
reaction name: thioredoxin-disulfide reductase
pathway: "Nucleotide biosynthesis, Pyrimidines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3913/trxB2
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  OTHIO[c] : thioredoxin_disulfide
  NAD[c] : nicotinamide_adenine_dinucleotide
  RTHIO[c] : reduced_thioredoxin

PPI[c] + UMP[c] -> PRPP[c] + URA[c]
reaction name: uracil phosphoribosyltransferase
pathway: "Nucleotide biosynthesis, Pyrimidines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3309c/upp
metabolites:
  PPI[c] : pyrophosphate
  UMP[c] : uridine-monophosphate
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  URA[c] : uracil

PRPP[c] + URA[c] -> PPI[c] + UMP[c]
reaction name: uracil phosphoribosyltransferase
pathway: "Nucleotide biosynthesis, Pyrimidines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3309c/upp
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  URA[c] : uracil
  PPI[c] : pyrophosphate
  UMP[c] : uridine-monophosphate

GLN[c] + PRPP[c] -> PPI[c] + GLU[c] + PRAM[c]
reaction name: amidophosphoribosyltransferase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0808/purF
metabolites:
  GLN[c] : glutamine
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  PPI[c] : pyrophosphate
  GLU[c] : glutamate
  PRAM[c] : 5-phosphoribosylamine

ATP[c] + GLY[c] + PRAM[c] -> ADP[c] + PI[c] + GAR[c]
reaction name: phosphoribosylamine-glycine ligase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0772/purD
metabolites:
  ATP[c] : adenosine-triphosphate
  GLY[c] : glycine
  PRAM[c] : 5-phosphoribosylamine
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  GAR[c] : 5-phospho-ribosyl-glycineamide

FTHF[c] + GAR[c] -> THF[c] + FGAR[c]
reaction name: phosphoribosylglycinamide formyltransferase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0956/purN
metabolites:
  FTHF[c] : 4-fumaryl-acetoacetate
  GAR[c] : 5-phospho-ribosyl-glycineamide
  THF[c] : tetrahydrofolate
  FGAR[c] : 5-phosphoribosyl-N-formylglycineamide

ATP[c] + GLN[c] + FGAR[c] -> ADP[c] + PI[c] + GLU[c] + FGAM[c]
reaction name: phosphoribosylformylglycinamidine synthase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0803/purL
metabolites:
  ATP[c] : adenosine-triphosphate
  GLN[c] : glutamine
  FGAR[c] : 5-phosphoribosyl-N-formylglycineamide
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  GLU[c] : glutamate
  FGAM[c] : 5-phosphoribosyl-N-formylglycineamidine

ATP[c] + FGAM[c] -> ADP[c] + PI[c] + AIR[c]
reaction name: phosphoribosylformylglycinamidine cyclo-ligase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0809/purM
metabolites:
  ATP[c] : adenosine-triphosphate
  FGAM[c] : 5-phosphoribosyl-N-formylglycineamidine
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  AIR[c] : 5-aminoimidazole_ribonucleotide

ATP[c] + AIR[c] + HCO3[c] -> ADP[c] + PI[c] + CAIR[c]
reaction name: phosphoribosylaminoimidazole carboxylase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3276c/purK
metabolites:
  ATP[c] : adenosine-triphosphate
  AIR[c] : 5-aminoimidazole_ribonucleotide
  HCO3[c] : bicarbonate
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  CAIR[c] : 4-carboxyaminoimidazole_ribonucleotide

ATP[c] + ASP[c] + CAIR[c] -> ADP[c] + PI[c] + SAICAR[c]
reaction name: "phosphoribosylaminoimidazolesuccinocarboxamide synthase, purC"
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0780/hemH
metabolites:
  ATP[c] : adenosine-triphosphate
  ASP[c] : L-aspartate
  CAIR[c] : 4-carboxyaminoimidazole_ribonucleotide
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  SAICAR[c] : 5-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole

SAICAR[c] <=> FUM[c] + AICAR[c]
reaction name: adenylosuccinate lyase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0777/purB
metabolites:
  SAICAR[c] : 5-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole
  FUM[c] : fumarate
  AICAR[c] : amino-4-imidazolecarboxamide_ribotide

FTHF[c] + AICAR[c] <=> THF[c] + PRFICA[c]
reaction name: phosphoribosylaminoimidazolecarboxamide formyltransferase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0957/purH
metabolites:
  FTHF[c] : 4-fumaryl-acetoacetate
  AICAR[c] : amino-4-imidazolecarboxamide_ribotide
  THF[c] : tetrahydrofolate
  PRFICA[c] : phosphoribosyl-formamido-carboxamide

PRFICA[c] <=> IMP[c]
reaction name: phosphoribosylaminoimidazolecarboxamide formyltransferase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0957/purH
metabolites:
  PRFICA[c] : phosphoribosyl-formamido-carboxamide
  IMP[c] : inosine-5-phosphate

ATP[c] -> PPI[c] + cAMP[c]
reaction name: adenylate cyclase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv1625c/cya or Rv1264/- or Rv1647/- or Rv2212/- or Rv0386/- or Rv1318c/- or Rv1319c/- or Rv1320c/- or Rv3645/- or Rv1900c/lipJ
metabolites:
  ATP[c] : adenosine-triphosphate
  PPI[c] : pyrophosphate
  cAMP[c] : cyclic-AMP

GTP[c] -> PPI[c] + cGMP[c]
reaction name: Probable Adenylate-or Guanylate cyclase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv2435c/-
metabolites:
  GTP[c] : guanosine-triphosphate
  PPI[c] : pyrophosphate
  cGMP[c] : cyclic-GMP

cAMP[c] -> AMP[c]
reaction name: "3,5-cyclic-nucleotide phosphodiesterase"
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0805/-
metabolites:
  cAMP[c] : cyclic-AMP
  AMP[c] : adenosine-monophosphate

cGMP[c] -> GMP[c]
reaction name: "3,5-cyclic-nucleotide phosphodiesterase"
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv0805/-
metabolites:
  cGMP[c] : cyclic-GMP
  GMP[c] : guanosine-monophosphate

ATP[c] + DGMP[c] <=> ADP[c] + DGDP[c]
reaction name: guanylate kinase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv1389/gmk
metabolites:
  ATP[c] : adenosine-triphosphate
  DGMP[c] : deoxyguanosine-monophosphate
  ADP[c] : adenosine-diphosphate
  DGDP[c] : deoxyguanosine-diphosphate

GMP[c] + DATP[c] <=> GDP[c] + DADP[c]
reaction name: guanylate kinase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv1389/gmk
metabolites:
  GMP[c] : guanosine-monophosphate
  DATP[c] : deoxyadenosine-triphosphate
  GDP[c] : guanosine_diphosphate
  DADP[c] : deoxyadenosine-diphosphate

ATP[c] + DUDP[c] <=> ADP[c] + DUTP[c]
reaction name: nucleoside-diphosphate kinase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv2445c/ndk
metabolites:
  ATP[c] : adenosine-triphosphate
  DUDP[c] : deoxyuridine-diphosphate
  ADP[c] : adenosine-diphosphate
  DUTP[c] : deoxyuridine-triphosphate

UDP[c] + O2[c] + RTHIO[c] -> OTHIO[c] + DUDP[c]
reaction name: "ribonucleoside-diphosphate reductase, nrdE and nrdF2"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv3051c/nrdE AND Rv3048c/nrdF
metabolites:
  UDP[c] : uridine-diphosphate
  O2[c] : oxygen
  RTHIO[c] : reduced_thioredoxin
  OTHIO[c] : thioredoxin_disulfide
  DUDP[c] : deoxyuridine-diphosphate

UDP[c] + RTHIO[c] + COB_45_II[c] -> OTHIO[c] + DUDP[c] + COB_45_III[c]
reaction name: "ribonucleoside-diphosphate reductase, nrdZ"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv0570/nrdZ
metabolites:
  UDP[c] : uridine-diphosphate
  RTHIO[c] : reduced_thioredoxin
  COB_45_II[c] : COB-II
  OTHIO[c] : thioredoxin_disulfide
  DUDP[c] : deoxyuridine-diphosphate
  COB_45_III[c] : COB-III

PI[c] + 5MTA[c] -> MTR1P[c] + AD[c]
reaction name: Probable 5-Methylthioadenosine Phosphorylase PNP
pathway: Other nucleotide metabolism
subsystem: Nucleotide biosynthesis
enzymes: Rv0535/pnp
metabolites:
  PI[c] : phosphate
  5MTA[c] : 5-methylthioadenosine
  MTR1P[c] : 5-methylthioribose-1-phosphate
  AD[c] : adenine

PRPP[c] + AD[c] -> PPI[c] + AMP[c]
reaction name: adenine phosphoribosyltransferase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv2584c/apt
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  AD[c] : adenine
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate

PRPP[c] + GN[c] -> PPI[c] + GMP[c]
reaction name: Hypoxanthine-guanine phosphoribosyltransferase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3624c/hpt
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  GN[c] : guanine
  PPI[c] : pyrophosphate
  GMP[c] : guanosine-monophosphate

PRPP[c] + HYXN[c] -> PPI[c] + IMP[c]
reaction name: Hypoxanthine-guanine phosphoribosyltransferase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3624c/hpt
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  HYXN[c] : hypoxanthine
  PPI[c] : pyrophosphate
  IMP[c] : inosine-5-phosphate

PRPP[c] + XAN[c] -> PPI[c] + XMP[c]
reaction name: Xanthine phosphoribosyltransferase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: orphan
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  XAN[c] : xanthine
  PPI[c] : pyrophosphate
  XMP[c] : xanthosine-5-phosphate

PI[c] + DIN[c] <=> HYXN[c] + DR1P[c]
reaction name: purine-nucleoside phosphorylase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3307/deoD
metabolites:
  PI[c] : phosphate
  DIN[c] : deoxyinosine
  HYXN[c] : hypoxanthine
  DR1P[c] : deoxyribose-1-phosphate

PI[c] + DA[c] <=> AD[c] + DR1P[c]
reaction name: purine-nucleoside phosphorylase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3307/deoD
metabolites:
  PI[c] : phosphate
  DA[c] : deoxyadenosine
  AD[c] : adenine
  DR1P[c] : deoxyribose-1-phosphate

DR1P[c] <=> R5P[c]
reaction name: phosphoglucomutase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3068c/pgmA
metabolites:
  DR1P[c] : deoxyribose-1-phosphate
  R5P[c] : D-ribose-5-phosphate

R1P[c] + HYXN[c] <=> PI[c] + INS[c]
reaction name: purine-nucleoside phosphorylase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3307/deoD
metabolites:
  R1P[c] : ribose-1-phosphate
  HYXN[c] : hypoxanthine
  PI[c] : phosphate
  INS[c] : inosine

R1P[c] + AD[c] <=> PI[c] + ADN[c]
reaction name: purine-nucleoside phosphorylase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3307/deoD
metabolites:
  R1P[c] : ribose-1-phosphate
  AD[c] : adenine
  PI[c] : phosphate
  ADN[c] : adenosine

R1P[c] + GN[c] <=> PI[c] + GSN[c]
reaction name: purine-nucleoside phosphorylase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3307/deoD
metabolites:
  R1P[c] : ribose-1-phosphate
  GN[c] : guanine
  PI[c] : phosphate
  GSN[c] : guanosine

R1P[c] + XAN[c] <=> PI[c] + XTSINE[c]
reaction name: purine-nucleoside phosphorylase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3307/deoD
metabolites:
  R1P[c] : ribose-1-phosphate
  XAN[c] : xanthine
  PI[c] : phosphate
  XTSINE[c] : xanthosine

XTSINE[c] -> RIB[c] + XAN[c]
reaction name: ribonucleoside hydrolase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: orphan
metabolites:
  XTSINE[c] : xanthosine
  RIB[c] : Ribose
  XAN[c] : xanthine

ADN[c] -> NH3[c] + INS[c]
reaction name: adenosine deaminase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3313c/add
metabolites:
  ADN[c] : adenosine
  NH3[c] : ammonia
  INS[c] : inosine

DA[c] -> NH3[c] + DIN[c]
reaction name: adenosine deaminase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv3313c/add
metabolites:
  DA[c] : deoxyadenosine
  NH3[c] : ammonia
  DIN[c] : deoxyinosine

DGTP[c] -> PPI[c] + DGMP[c]
reaction name: dGTP pyrophosphohydrolase mutT
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: orphan
metabolites:
  DGTP[c] : deoxyguanosine-triphosphate
  PPI[c] : pyrophosphate
  DGMP[c] : deoxyguanosine-monophosphate

ATP[c] + GTP[c] -> AMP[c] + ppGpp[c]
reaction name: GTP diphosphokinase
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv2583c/relA
metabolites:
  ATP[c] : adenosine-triphosphate
  GTP[c] : guanosine-triphosphate
  AMP[c] : adenosine-monophosphate
  ppGpp[c] : ppgpp

ppGpp[c] -> GDP[c] + PPI[c]
reaction name: "guanosine-3,5-bis(diphosphate) 3-diphosphatase"
pathway: "Nucleotide biosynthesis, Purines"
subsystem: Nucleotide biosynthesis
enzymes: Rv2583c/relA
metabolites:
  ppGpp[c] : ppgpp
  GDP[c] : guanosine_diphosphate
  PPI[c] : pyrophosphate

GTP[c] + ASP[c] + IMP[c] -> PI[c] + GDP[c] + ASUC[c]
reaction name: adenylosuccinate synthase
pathway: "Nucleotide biosynthesis, Purines, ATP, ADP"
subsystem: Nucleotide biosynthesis
enzymes: Rv0357c/purA
metabolites:
  GTP[c] : guanosine-triphosphate
  ASP[c] : L-aspartate
  IMP[c] : inosine-5-phosphate
  PI[c] : phosphate
  GDP[c] : guanosine_diphosphate
  ASUC[c] : adenylo-succinate

ASUC[c] <=> FUM[c] + AMP[c]
reaction name: adenylosuccinate lyase
pathway: "Nucleotide biosynthesis, Purines, ATP, ADP"
subsystem: Nucleotide biosynthesis
enzymes: Rv0777/purB
metabolites:
  ASUC[c] : adenylo-succinate
  FUM[c] : fumarate
  AMP[c] : adenosine-monophosphate

ATP[c] + AMP[c] <=> 2 ADP[c]
reaction name: adenylate kinase
pathway: "Nucleotide biosynthesis, Purines, ATP, ADP"
subsystem: Nucleotide biosynthesis
enzymes: Rv0733/adk
metabolites:
  ATP[c] : adenosine-triphosphate
  AMP[c] : adenosine-monophosphate
  ADP[c] : adenosine-diphosphate

ATP[c] + ADN[c] <=> ADP[c] + AMP[c]
reaction name:
pathway:
subsystem: Nucleotide biosynthesis
enzymes: Rv2202c/cbhK
metabolites:
  ATP[c] : adenosine-triphosphate
  ADN[c] : adenosine
  ADP[c] : adenosine-diphosphate
  AMP[c] : adenosine-monophosphate

ADP[c] + O2[c] + RTHIO[c] -> OTHIO[c] + DADP[c]
reaction name: "ribonucleoside-diphosphate reductase, nrdE and nrdF2"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv3051c/nrdE AND Rv3048c/nrdF
metabolites:
  ADP[c] : adenosine-diphosphate
  O2[c] : oxygen
  RTHIO[c] : reduced_thioredoxin
  OTHIO[c] : thioredoxin_disulfide
  DADP[c] : deoxyadenosine-diphosphate

ADP[c] + RTHIO[c] + COB_II[c] -> OTHIO[c] + COB_III[c] + DADP[c]
reaction name: "ribonucleoside-diphosphate reductase, nrdZ"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv0570/nrdZ
metabolites:
  ADP[c] : adenosine-diphosphate
  RTHIO[c] : reduced_thioredoxin
  COB_II[c] : COB-II
  OTHIO[c] : thioredoxin_disulfide
  COB_III[c] : COB-III
  DADP[c] : deoxyadenosine-diphosphate

ATP[c] + DADP[c] <=> ADP[c] + DATP[c]
reaction name: nucleoside-diphosphate kinase
pathway: "Nucleotide biosynthesis, Purines, ATP, ADP"
subsystem: Nucleotide biosynthesis
enzymes: Rv2445c/ndk
metabolites:
  ATP[c] : adenosine-triphosphate
  DADP[c] : deoxyadenosine-diphosphate
  ADP[c] : adenosine-diphosphate
  DATP[c] : deoxyadenosine-triphosphate

NAD[c] + IMP[c] -> NADH[c] + XMP[c]
reaction name: "IMP dehydrogenase guaB1, guaB2, guaB3"
pathway: "Nucleotide biosynthesis, Purines, GTP, dGTP"
subsystem: Nucleotide biosynthesis
enzymes: Rv3411c/guaB2 AND Rv3410c/guaB3 AND Rv1843c/guaB1
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  IMP[c] : inosine-5-phosphate
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  XMP[c] : xanthosine-5-phosphate

ATP[c] + GLN[c] + XMP[c] -> PPI[c] + AMP[c] + GLU[c] + GMP[c]
reaction name: GMP synthase
pathway: "Nucleotide biosynthesis, Purines, GTP, dGTP"
subsystem: Nucleotide biosynthesis
enzymes: Rv3396c/guaA
metabolites:
  ATP[c] : adenosine-triphosphate
  GLN[c] : glutamine
  XMP[c] : xanthosine-5-phosphate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  GLU[c] : glutamate
  GMP[c] : guanosine-monophosphate

ATP[c] + GMP[c] <=> ADP[c] + GDP[c]
reaction name: guanylate kinase
pathway: "Nucleotide biosynthesis, Purines, GTP, dGTP"
subsystem: Nucleotide biosynthesis
enzymes: Rv1389/gmk
metabolites:
  ATP[c] : adenosine-triphosphate
  GMP[c] : guanosine-monophosphate
  ADP[c] : adenosine-diphosphate
  GDP[c] : guanosine_diphosphate

ATP[c] + GDP[c] <=> ADP[c] + GTP[c]
reaction name: nucleoside-diphosphate kinase
pathway: "Nucleotide biosynthesis, Purines, GTP, dGTP"
subsystem: Nucleotide biosynthesis
enzymes: Rv2445c/ndk
metabolites:
  ATP[c] : adenosine-triphosphate
  GDP[c] : guanosine_diphosphate
  ADP[c] : adenosine-diphosphate
  GTP[c] : guanosine-triphosphate

GDP[c] + O2[c] + RTHIO[c] -> OTHIO[c] + DGDP[c]
reaction name: "ribonucleoside-diphosphate reductase, nrdE and nrdF2"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv3051c/nrdE AND Rv3048c/nrdF
metabolites:
  GDP[c] : guanosine_diphosphate
  O2[c] : oxygen
  RTHIO[c] : reduced_thioredoxin
  OTHIO[c] : thioredoxin_disulfide
  DGDP[c] : deoxyguanosine-diphosphate

GDP[c] + RTHIO[c] + COB_45_II[c] -> OTHIO[c] + DGDP[c] + COB_45_III[c]
reaction name: "ribonucleoside-diphosphate reductase, nrdZ"
pathway: "Nucleotide biosynthesis, de novo biosynthesis of pyrimidine ribonucleotides "
subsystem: Nucleotide biosynthesis
enzymes: Rv0570/nrdZ
metabolites:
  GDP[c] : guanosine_diphosphate
  RTHIO[c] : reduced_thioredoxin
  COB_45_II[c] : COB-II
  OTHIO[c] : thioredoxin_disulfide
  DGDP[c] : deoxyguanosine-diphosphate
  COB_45_III[c] : COB-III

ATP[c] + DGDP[c] <=> ADP[c] + DGTP[c]
reaction name: nucleoside-diphosphate kinase
pathway: "Nucleotide biosynthesis, Purines, GTP, dGTP"
subsystem: Nucleotide biosynthesis
enzymes: Rv2445c/ndk
metabolites:
  ATP[c] : adenosine-triphosphate
  DGDP[c] : deoxyguanosine-diphosphate
  ADP[c] : adenosine-diphosphate
  DGTP[c] : deoxyguanosine-triphosphate

FUM[c] + ASP[c] -> SUCC[c] + ISUCC[c]
reaction name: L-aspartate oxidase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1595/nadB
metabolites:
  FUM[c] : fumarate
  ASP[c] : L-aspartate
  SUCC[c] : succinate
  ISUCC[c] : iminoaspartate_(-iminosuccinate)

O2[c] + ASP[c] -> H2O2[c] + ISUCC[c]
reaction name: L-aspartate oxidase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1595/nadB
metabolites:
  O2[c] : oxygen
  ASP[c] : L-aspartate
  H2O2[c] : hydrogen_peroxide
  ISUCC[c] : iminoaspartate_(-iminosuccinate)

DHAP[c] + ISUCC[c] -> PI[c] + QA[c]
reaction name: quinolinate synthase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1594/nadA
metabolites:
  DHAP[c] : dihydroxyacetone-phosphate
  ISUCC[c] : iminoaspartate_(-iminosuccinate)
  PI[c] : phosphate
  QA[c] : quinolinate

PRPP[c] + QA[c] -> PPI[c] + CO2[c] + NACN[c]
reaction name: nicotinate-nucleotide diphosphorylase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1596/nadC
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  QA[c] : quinolinate
  PPI[c] : pyrophosphate
  CO2[c] : carbon_dioxide
  NACN[c] : nicotinate_nucleotide

h2o[c] + NAM[c] <=> NH3[c] + NAC[c]
reaction name: nicotinamidase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2043c/pncA
metabolites:
  h2o[c] : water
  NAM[c] : nicotinamide
  NH3[c] : ammonia
  NAC[c] : nicotinate

PRPP[c] + NAC[c] -> PPI[c] + NACN[c]
reaction name: nicotinate phosphoribosyltransferase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0573c/-
metabolites:
  PRPP[c] : 5-phosphoribosyl_1-pyrophosphate
  NAC[c] : nicotinate
  PPI[c] : pyrophosphate
  NACN[c] : nicotinate_nucleotide

ATP[c] + NACN[c] -> PPI[c] + NAAD[c]
reaction name: nicotinate-nucleotide adenylyltransferase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2421c/nadD
metabolites:
  ATP[c] : adenosine-triphosphate
  NACN[c] : nicotinate_nucleotide
  PPI[c] : pyrophosphate
  NAAD[c] : deamido-nad

ATP[c] + NH3[c] + NAAD[c] -> NAD[c] + PPI[c] + AMP[c]
reaction name: "NAD synthetase (NH3-dependent), nadE"
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2438c/nadE
metabolites:
  ATP[c] : adenosine-triphosphate
  NH3[c] : ammonia
  NAAD[c] : deamido-nad
  NAD[c] : nicotinamide_adenine_dinucleotide
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate

ATP[c] + GLN[c] + NAAD[c] -> NAD[c] + PPI[c] + AMP[c] + GLU[c]
reaction name: "NAD synthase (glutamine-hydrolysing), nadE"
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2438c/nadE
metabolites:
  ATP[c] : adenosine-triphosphate
  GLN[c] : glutamine
  NAAD[c] : deamido-nad
  NAD[c] : nicotinamide_adenine_dinucleotide
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  GLU[c] : glutamate

R1P[c] + NAC[c] -> PI[c] + NACD[c]
reaction name: purine-nucleoside phosphorylase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3307/deoD
metabolites:
  R1P[c] : ribose-1-phosphate
  NAC[c] : nicotinate
  PI[c] : phosphate
  NACD[c] : nicotinate_ribonucleoside

R1P[c] + NAM[c] -> PI[c] + NAMD[c]
reaction name: purine-nucleoside phosphorylase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3307/deoD
metabolites:
  R1P[c] : ribose-1-phosphate
  NAM[c] : nicotinamide
  PI[c] : phosphate
  NAMD[c] : nicotinamide_riboside

ATP[c] + NACD[c] -> ADP[c] + NACN[c]
reaction name: serine/threonine-protein kinase PknG
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0410c/pknG
metabolites:
  ATP[c] : adenosine-triphosphate
  NACD[c] : nicotinate_ribonucleoside
  ADP[c] : adenosine-diphosphate
  NACN[c] : nicotinate_nucleotide

ATP[c] + NAMD[c] -> ADP[c] + NAMN[c]
reaction name: ribosylnicotinamide kinase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  ATP[c] : adenosine-triphosphate
  NAMD[c] : nicotinamide_riboside
  ADP[c] : adenosine-diphosphate
  NAMN[c] : nicotinamide_mononucleotide

ATP[c] + NAMN[c] -> NAD[c] + PPI[c]
reaction name: nicotinate-nucleotide adenylyltransferase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2421c/nadD
metabolites:
  ATP[c] : adenosine-triphosphate
  NAMN[c] : nicotinamide_mononucleotide
  NAD[c] : nicotinamide_adenine_dinucleotide
  PPI[c] : pyrophosphate

NAD[c] + NADPH[c] <=> NADH[c] + NADP[c]
reaction name: NAD(P) transhydrogenase (pntAa AND pntAb AND pntB)
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0155/pntAa AND Rv0157/pntB AND Rv0156/pntAb
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate

ATP[c] + NAD[c] -> ADP[c] + NADP[c]
reaction name: NAD kinase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1695/ppnK
metabolites:
  ATP[c] : adenosine-triphosphate
  NAD[c] : nicotinamide_adenine_dinucleotide
  ADP[c] : adenosine-diphosphate
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate

NADP[c] -> NAD[c] + PI[c]
reaction name: NADP phosphatase
pathway: "Cofactor biosynthesis, Nicotinamide nucleotides (NAD+, NADP) biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  NAD[c] : nicotinamide_adenine_dinucleotide
  PI[c] : phosphate

NAD[c] + NADPH[c] -> NADH[c] + NADP[c]
reaction name: Probable Soluble Pyrimidine Nucleotide Transhydrogenase sthA
pathway: "Cofactor biosynthesis, Nicotinate and nicotinamide metabolism"
subsystem: Cofactor biosynthesis
enzymes: Rv2713/sthA OR Rv3303c/lpdA
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate

NAD[c] -> AMP[c] + NAMN[c]
reaction name: Probable NADH Pyrophosphatase nudC
pathway: "Cofactor biosynthesis, NAD salvage pathway II "
subsystem: Cofactor biosynthesis
enzymes: Rv3199c/nudC
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  AMP[c] : adenosine-monophosphate
  NAMN[c] : nicotinamide_mononucleotide

GTP[c] -> PPI[c] + FOR[c] + D6RP5P[c]
reaction name: "GTP cyclohydrolase II ribA2, ribA2"
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1415/ribA2 OR Rv1940/ribA1
metabolites:
  GTP[c] : guanosine-triphosphate
  PPI[c] : pyrophosphate
  FOR[c] : formate
  D6RP5P[c] : "2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone_5-phosphate"

D6RP5P[c] -> NH3[c] + A6RP5P[c]
reaction name: "diaminohydroxyphosphoribosylaminopyrimidine deaminase ribD, ribG"
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2671/ribD OR Rv1409/ribG
metabolites:
  D6RP5P[c] : "2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone_5-phosphate"
  NH3[c] : ammonia
  A6RP5P[c] : 5-amino-6-(5-phosphoribitylamino)uracil

NADPH[c] + A6RP5P[c] -> NADP[c] + A6RP5P2[c]
reaction name: 5-amino-6-(5-phosphoribosylamino)uracil reductase
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2671/ribD OR Rv1409/ribG
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  A6RP5P[c] : 5-amino-6-(5-phosphoribitylamino)uracil
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  A6RP5P2[c] : 5-amino-6-(5-phosphoribosylamino)uracil

A6RP5P2[c] -> PI[c] + A6RP[c]
reaction name: pyrimidine phosphatase
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  A6RP5P2[c] : 5-amino-6-(5-phosphoribosylamino)uracil
  PI[c] : phosphate
  A6RP[c] : 5-amino-6-(5-phosphoribosylamino)uracil

RL5P[c] -> FOR[c] + DB4P[c]
reaction name: "3,4-dihydroxy-2-butanone 4-phosphate synthase"
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1940/ribA1
metabolites:
  RL5P[c] : D-ribulose-5-phosphate
  FOR[c] : formate
  DB4P[c] : "2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone_5-phosphate"

A6RP[c] + DB4P[c] -> PI[c] + D8RL[c]
reaction name: "6,7-dimethyl-8-ribityllumazine synthase"
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1416/ribH
metabolites:
  A6RP[c] : 5-amino-6-(5-phosphoribosylamino)uracil
  DB4P[c] : "2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone_5-phosphate"
  PI[c] : phosphate
  D8RL[c] : "6,7-dimethyl-8-(1-D-ribityl)lumazine"

2 D8RL[c] -> A6RP[c] + RIBFLAV[c]
reaction name: riboflavin synthase
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1412/ribC
metabolites:
  D8RL[c] : "6,7-dimethyl-8-(1-D-ribityl)lumazine"
  A6RP[c] : 5-amino-6-(5-phosphoribosylamino)uracil
  RIBFLAV[c] : riboflavin

ATP[c] + RIBFLAV[c] -> ADP[c] + FMN[c]
reaction name: riboflavin kinase/FMN adenylyltransferase
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2786c/ribF
metabolites:
  ATP[c] : adenosine-triphosphate
  RIBFLAV[c] : riboflavin
  ADP[c] : adenosine-diphosphate
  FMN[c] : flavin_mononucleotide

H[c] + FMN[c] -> FMNH2[c]
reaction name: FMN reductase
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  H[c] : proton
  FMN[c] : flavin_mononucleotide
  FMNH2[c] : flavin_mononucleotide reduced

H[c] + NADH[c] + O2[c] + FMNH2[c] -> NAD[c] + E4P[c] + DMB[c]
reaction name: "5,6-dimethylbenzimidazole synthase, BluB"
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  H[c] : proton
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  O2[c] : oxygen
  FMNH2[c] : flavin_mononucleotide reduced
  NAD[c] : nicotinamide_adenine_dinucleotide
  E4P[c] : D-erythrose-4-phosphate
  DMB[c] : dimethylbenzimidazole

NACN[c] + DMB[c] -> ARP[c]
reaction name: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase, CobT"
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  NACN[c] : nicotinate_nucleotide
  DMB[c] : dimethylbenzimidazole
  ARP[c] : -ribazole 5-phosphate

ATP[c] + FMN[c] -> PPI[c] + FAD[c]
reaction name: FMN adenylyltransferase
pathway: "Cofactor biosynthesis, Riboflavin (vitamin B2), FMN and FAD biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2786c/ribF
metabolites:
  ATP[c] : adenosine-triphosphate
  FMN[c] : flavin_mononucleotide
  PPI[c] : pyrophosphate
  FAD[c] : flavin adenine dinucleotide

METTHF[c] + OMVAL[c] -> THF[c] + AKP[c]
reaction name: 3-methyl-2-oxobutanoate hydroxymethyltransferase
pathway: "Cofactor biosynthesis, Coenzyme-A biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2225/panB
metabolites:
  METTHF[c] : "5,10-methylene-THF"
  OMVAL[c] : 2-keto-3-methyl-valerate
  THF[c] : tetrahydrofolate
  AKP[c] : 2-dehydropantoate

NADPH[c] + AKP[c] -> NADP[c] + PANT[c]
reaction name: 2-dehydropantoate 2-reductase
pathway: "Cofactor biosynthesis, Coenzyme-A biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2573/-
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  AKP[c] : 2-dehydropantoate
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  PANT[c] : L-pantoate

ATP[c] + bALA[c] + PANT[c] -> PPI[c] + AMP[c] + PNTO[c]
reaction name: "pantoate-beta-alanine ligase, panC"
pathway: "Cofactor biosynthesis, Coenzyme-A biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3602c/panC
metabolites:
  ATP[c] : adenosine-triphosphate
  bALA[c] : -alanine
  PANT[c] : L-pantoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  PNTO[c] : pantothenate

ATP[c] + PNTO[c] -> ADP[c] + 4PPNTO[c]
reaction name: pantothenate kinase
pathway: "Cofactor biosynthesis, Coenzyme-A biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1092c/coaA
metabolites:
  ATP[c] : adenosine-triphosphate
  PNTO[c] : pantothenate
  ADP[c] : adenosine-diphosphate
  4PPNTO[c] : D-4-phosphopantothenate

CYS[c] + CTP[c] + 4PPNTO[c] -> PPI[c] + CMP[c] + 4PPNCYS[c]
reaction name: "phosphopantothenate—cysteine ligase, coaB (bifunctional protein)"
pathway: "Cofactor biosynthesis, Coenzyme-A biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1391/dfp
metabolites:
  CYS[c] : L-cysteine
  CTP[c] : cytidine-5-triphosphate
  4PPNTO[c] : D-4-phosphopantothenate
  PPI[c] : pyrophosphate
  CMP[c] : cytidine-monophosphate
  4PPNCYS[c] : R-4-phosphopantothenoyl-L-cysteine

4PPNCYS[c] -> CO2[c] + 4PPNTE[c]
reaction name: "phosphopantothenoylcysteine decarboxylase, coaB (bifunctional protein)"
pathway: "Cofactor biosynthesis, Coenzyme-A biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1391/dfp
metabolites:
  4PPNCYS[c] : R-4-phosphopantothenoyl-L-cysteine
  CO2[c] : carbon_dioxide
  4PPNTE[c] : pantetheine_4-phosphate

ATP[c] + 4PPNTE[c] -> PPI[c] + DPCOA[c]
reaction name: pantetheine-phosphate adenylyltransferase
pathway: "Cofactor biosynthesis, Coenzyme-A biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2965c/coaD
metabolites:
  ATP[c] : adenosine-triphosphate
  4PPNTE[c] : pantetheine_4-phosphate
  PPI[c] : pyrophosphate
  DPCOA[c] : dephospho-CoA

ATP[c] + DPCOA[c] -> ADP[c] + COA[c]
reaction name: dephospho-CoA kinase
pathway: "Cofactor biosynthesis, Coenzyme-A biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1631/coaE
metabolites:
  ATP[c] : adenosine-triphosphate
  DPCOA[c] : dephospho-CoA
  ADP[c] : adenosine-diphosphate
  COA[c] : coenzyme_A

COA[c] -> ACP[c]
reaction name: "holo-[acyl-carrier-protein] synthase acpS OR hypothetical withy 4-phosphopantetheinyl transferase region, pptA - artificial r... "
pathway: "Cofactor biosynthesis, ACP biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2523c/acpS OR Rv2794c/-
metabolites:
  COA[c] : coenzyme_A
  ACP[c] : acyl-carrier-protein

GTP[c] -> FOR[c] + AHTD[c]
reaction name: GTP cyclohydrolase I
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3609c/folE
metabolites:
  GTP[c] : guanosine-triphosphate
  FOR[c] : formate
  AHTD[c] : "7,8-dihydroneopterin_3-triphosphate"

AHTD[c] -> 3 PI[c] + DHP[c]
reaction name: alkaline phosphatase (phoP & phoR)
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0757/phoP AND Rv0758/phoR
metabolites:
  AHTD[c] : "7,8-dihydroneopterin_3-triphosphate"
  PI[c] : phosphate
  DHP[c] : dihydro-neo-pterin

DHP[c] -> GLAL[c] + AHHMP[c]
reaction name: dihydroneopterin aldolase [note: GLAL product removed as it is a dead-end]
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3607c/folB
metabolites:
  DHP[c] : dihydro-neo-pterin
  GLAL[c] : glycolaldehyde
  AHHMP[c] : 6-hydroxymethyl-dihydropterin

ATP[c] + AHHMP[c] -> AMP[c] + AHHMD[c]
reaction name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3606c/folK
metabolites:
  ATP[c] : adenosine-triphosphate
  AHHMP[c] : 6-hydroxymethyl-dihydropterin
  AMP[c] : adenosine-monophosphate
  AHHMD[c] : "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine_diphosphate"

GLN[c] + CHOR[c] -> GLU[c] + ADCHOR[c]
reaction name: aminodeoxychorismate synthase
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0013/trpG
metabolites:
  GLN[c] : glutamine
  CHOR[c] : chorismate
  GLU[c] : glutamate
  ADCHOR[c] : 4-amino-4-deoxychorismate

ADCHOR[c] -> PYR[c] + PABA[c]
reaction name: aminodeoxychorismate lyase
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0812/-
metabolites:
  ADCHOR[c] : 4-amino-4-deoxychorismate
  PYR[c] : pyruvate
  PABA[c] : para-aminobenzoic_acid

AHHMD[c] + PABA[c] -> PPI[c] + DHPT[c]
reaction name: "dihydropteroate synthase, DHPS or probable dihydropteroate synthase"
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3608c/folP1 OR Rv1207/folP2
metabolites:
  AHHMD[c] : "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine_diphosphate"
  PABA[c] : para-aminobenzoic_acid
  PPI[c] : pyrophosphate
  DHPT[c] : "7,8-dihydropteroate"

AHHMP[c] + PABA[c] -> DHPT[c]
reaction name: "dihydropteroate synthase, DHPS or probable dihydropteroate synthase"
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3608c/folP1 OR Rv1207/folP2
metabolites:
  AHHMP[c] : 6-hydroxymethyl-dihydropterin
  PABA[c] : para-aminobenzoic_acid
  DHPT[c] : "7,8-dihydropteroate"

ATP[c] + GLU[c] + DHPT[c] -> ADP[c] + PI[c] + DHF[c]
reaction name: dihydrofolate synthase
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2447c/folC
metabolites:
  ATP[c] : adenosine-triphosphate
  GLU[c] : glutamate
  DHPT[c] : "7,8-dihydropteroate"
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  DHF[c] : "7,8-dihydrofolate"

NADPH[c] + DHF[c] -> NADP[c] + THF[c]
reaction name: "dihydrofolate reductase, folA (dfrA)"
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2763c/dfrA
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  DHF[c] : "7,8-dihydrofolate"
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  THF[c] : tetrahydrofolate

ATP[c] + GLU[c] + THF[c] -> ADP[c] + PI[c] + THFG[c]
reaction name: tetrahydrofolylpolyglutamate synthase
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2447c/folC
metabolites:
  ATP[c] : adenosine-triphosphate
  GLU[c] : glutamate
  THF[c] : tetrahydrofolate
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  THFG[c] : THF-L-glutamate

THFG[c] -> GLU[c] + THF[c]
reaction name: g-glutamyl hydrolase
pathway: "Cofactor biosynthesis, Folate biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  THFG[c] : THF-L-glutamate
  GLU[c] : glutamate
  THF[c] : tetrahydrofolate

FE2[c] + CYS[c] -> FERO[c] + ALA[c]
reaction name: cysteine desulfurase nifS OR csdB
pathway: "Cofactor biosynthesis, ferredoxin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3025c/iscS OR Rv1464/csd
metabolites:
  FE2[c] : ferrous iron
  CYS[c] : L-cysteine
  FERO[c] : reduced ferredoxin
  ALA[c] : D-alanine

CHOR[c] <=> ICHOR[c]
reaction name: "isochorismate synthase entC, mbt1"
pathway: "Cofactor biosynthesis, Menaquinone biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3215/entC OR Rv2386c/mbtI
metabolites:
  CHOR[c] : chorismate
  ICHOR[c] : isochorismate

AKG[c] + ICHOR[c] -> CO2[c] + PYR[c] + SHCHC[c]
reaction name: "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase"
pathway: "Cofactor biosynthesis, Menaquinone biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0555/menD
metabolites:
  AKG[c] : -ketoglutarate
  ICHOR[c] : isochorismate
  CO2[c] : carbon_dioxide
  PYR[c] : pyruvate
  SHCHC[c] : "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate"

SHCHC[c] -> OSB[c]
reaction name: o-succinylbenzoate synthase
pathway: "Cofactor biosynthesis, Menaquinone biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  SHCHC[c] : "2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate"
  OSB[c] : O-succinylbenzoate

ATP[c] + COA[c] + OSB[c] -> PPI[c] + AMP[c] + OSBCOA[c]
reaction name: o-succinylbenzoate-CoA ligase
pathway: "Cofactor biosynthesis, Menaquinone biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0542c/menE AND Rv0553/menC
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  OSB[c] : O-succinylbenzoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  OSBCOA[c] : O-succinylbenzoyl-CoA

OSBCOA[c] -> COA[c] + DHN[c]
reaction name: "naphthoate synthase, menB"
pathway: "Cofactor biosynthesis, Menaquinone biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0548c/menB
metabolites:
  OSBCOA[c] : O-succinylbenzoyl-CoA
  COA[c] : coenzyme_A
  DHN[c] : "1,4-dihydroxy-2-naphthoate"

DHN[c] + NPP[c] -> PPI[c] + CO2[c] + DMK[c]
reaction name: "1,4-dihydroxy-2-naphthoate prenyltransferase, menA "
pathway: "Cofactor biosynthesis, Menaquinone biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0534c/menA
metabolites:
  DHN[c] : "1,4-dihydroxy-2-naphthoate"
  NPP[c] : nerylpyrophosphate
  PPI[c] : pyrophosphate
  CO2[c] : carbon_dioxide
  DMK[c] : 3-demethylubiquinone-8

SAM[c] + DMK[c] -> MKH2[c] + SAH[c]
reaction name: demethylmenaquinone methyltransferase
pathway: "Cofactor biosynthesis, Menaquinone biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  DMK[c] : 3-demethylubiquinone-8
  MKH2[c] : ubiquinol-8
  SAH[c] : S-adenosyl-L-homocysteine

4 ACCOA[c] -> 3 COA[c] + PIMELOYL_COA[c]
reaction name: hypothetical reaction
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  ACCOA[c] : acetyl-CoA
  COA[c] : coenzyme_A
  PIMELOYL_COA[c] : pimeloyl-coa

ALA[c] + PIMELOYL_COA[c] -> CO2[c] + COA[c] + 8_AMINO7_OXONOOATE[c]
reaction name: "probable-8-amino-7-oxonooate synthase bioF1, bioF2"
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1569/bioF1 AND Rv0032/bioF2
metabolites:
  ALA[c] : D-alanine
  PIMELOYL_COA[c] : pimeloyl-coa
  CO2[c] : carbon_dioxide
  COA[c] : coenzyme_A

SAM[c] + 8_AMINO7_OXONOOATE[c] -> 7_8_DIAMINONOOATE[c] + SAM_2_OXOBUTANOATE[c]
reaction name: probable adenosylmethionine-8-amino-7-oxonooate amino transferase bioA
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1568/bioA
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  SAM_2_OXOBUTANOATE[c] : S-adenosyl-4-methylthio-2-oxobutanoate

SAM_2_OXOBUTANOATE[c] -> SAM[c]
reaction name: artificial reaction to regenerate SAM
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  SAM_2_OXOBUTANOATE[c] : S-adenosyl-4-methylthio-2-oxobutanoate
  SAM[c] : S-adenosyl-L-methionine

ATP[c] + CO2[c] + 7_8_DIAMINONOOATE[c] -> ADP[c] + DETHIOBIOTIN[c]
reaction name: probable dethiobiotin synthase bioD
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1570/bioD
metabolites:
  ATP[c] : adenosine-triphosphate
  CO2[c] : carbon_dioxide
  ADP[c] : adenosine-diphosphate
  DETHIOBIOTIN[c] : dethiobiotin

H2S[c] + SAM[c] + DETHIOBIOTIN[c] -> BIOTIN[c] + DA[c]
reaction name: biotin synthase bioB
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1589/bioB
metabolites:
  H2S[c] : hydrogen_sulfide
  SAM[c] : S-adenosyl-L-methionine
  DETHIOBIOTIN[c] : dethiobiotin
  BIOTIN[c] : biotin
  DA[c] : deoxyadenosine

CO2[c] -> HCO3[c]
reaction name: carbonic anhydrase
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3588c/- OR Rv1284/-
metabolites:
  CO2[c] : carbon_dioxide
  HCO3[c] : bicarbonate

ATP[c] + BIOTIN[c] -> PPI[c] + AMP[c] + BIOTIN_BCCP[c]
reaction name: "biotin—[acetyl-CoA-carboxylase] ligase, birA"
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3279c/birA
metabolites:
  ATP[c] : adenosine-triphosphate
  BIOTIN[c] : biotin
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  BIOTIN_BCCP[c] : biotin-BCCP

ATP[c] + HCO3[c] + BIOTIN_BCCP[c] -> ADP[c] + PI[c] + BIOTIN_CO2[c]
reaction name: "acetyl/propionyl-CoA carboxylase alpha subunit encoding both biotin carboxylase and BCCP. Three paralogues in Mtb: accA1, accA2,... "
pathway: "Cofactor biosynthesis, biotin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2501c/accA1 OR Rv0973c/accA2 OR Rv3285/accA3
metabolites:
  ATP[c] : adenosine-triphosphate
  HCO3[c] : bicarbonate
  BIOTIN_BCCP[c] : biotin-BCCP
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  BIOTIN_CO2[c] : BCCP-biotin-CO2

OCTANOYL_ACP[c] -> ACP[c] + APO_LIPO[c]
reaction name: lipoyl-protein ligase lipB
pathway: "Cofactor biosynthesis, lipoic acid biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2217/lipB
metabolites:
  OCTANOYL_ACP[c] : octanoyl-acp
  ACP[c] : acyl-carrier-protein
  APO_LIPO[c] : apolipo protein

2 H2S[c] + 2 SAM[c] + APO_LIPO[c] -> LIPO[c] + 2 MET[c] + 2 DA[c]
reaction name: "lipoate synthase, lipA"
pathway: "Cofactor biosynthesis, lipoic acid biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2218/lipA
metabolites:
  H2S[c] : hydrogen_sulfide
  SAM[c] : S-adenosyl-L-methionine
  APO_LIPO[c] : apolipo protein
  LIPO[c] : enzyme N6-(lipoyl)lysine
  MET[c] : methionine
  DA[c] : deoxyadenosine

ATP[c] + GLU[c] -> PPI[c] + AMP[c] + TRNA_GLU[c]
reaction name: "glutamyl-tRNA synthase, gltS"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2992c/gltX
metabolites:
  ATP[c] : adenosine-triphosphate
  GLU[c] : glutamate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  TRNA_GLU[c] : tRNAGlu

NADPH[c] + TRNA_GLU[c] -> NADP[c] + GLU1SEMIALD[c]
reaction name: "glutamyl-trna reductase, hemA"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0509/hemA
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  TRNA_GLU[c] : tRNAGlu
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  GLU1SEMIALD[c] : glutamate-1-semialdehyde

GLU1SEMIALD[c] -> 5_AMINO_LEVULINATE[c]
reaction name: "glutamate-1-semialdehyde 2,1-aminomutase, hemL"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0524/hemL
metabolites:
  GLU1SEMIALD[c] : glutamate-1-semialdehyde
  5_AMINO_LEVULINATE[c] : 5-amino-levulinate

2 5_AMINO_LEVULINATE[c] -> PORPHOBILILOGIN[c]
reaction name: "delta-aminolevulinic acid dehydratase, hemB"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0512/hemB
metabolites:
  5_AMINO_LEVULINATE[c] : 5-amino-levulinate
  PORPHOBILILOGIN[c] : porphobilinogen

4 PORPHOBILILOGIN[c] -> 4 NH3[c] + HYDROXYMETHYLBILANE[c]
reaction name: "porphobilinogen deaminase, hemC"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0510/hemC
metabolites:
  PORPHOBILILOGIN[c] : porphobilinogen
  NH3[c] : ammonia
  HYDROXYMETHYLBILANE[c] : hydroxymethylbilane

HYDROXYMETHYLBILANE[c] -> UROPORPHYRINOGEN_III[c]
reaction name: "uroporphyrin-iii c-methyltransferase / Uroporphyrinogen-III synthase, cysG"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0511/hemD
metabolites:
  HYDROXYMETHYLBILANE[c] : hydroxymethylbilane
  UROPORPHYRINOGEN_III[c] : uroporphyrinogen-III

UROPORPHYRINOGEN_III[c] -> 4 CO2[c] + COPROPORPHYRINOGEN_III[c]
reaction name: "Probable uroporphyrinogen decarboxylase, hemE"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2678c/hemE
metabolites:
  UROPORPHYRINOGEN_III[c] : uroporphyrinogen-III
  CO2[c] : carbon_dioxide
  COPROPORPHYRINOGEN_III[c] : coproporphyrinogen_III

2 O2[c] + COPROPORPHYRINOGEN_III[c] -> 2 CO2[c] + 2 H2O2[c] + PROTOPORPHYRINOGEN[c]
reaction name: coproporphyrinogen:oxygen oxidoreductase (decarboxylating)
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  O2[c] : oxygen
  COPROPORPHYRINOGEN_III[c] : coproporphyrinogen_III
  CO2[c] : carbon_dioxide
  H2O2[c] : hydrogen_peroxide
  PROTOPORPHYRINOGEN[c] : protoporphyrinogen_IX

2 SAM[c] + COPROPORPHYRINOGEN_III[c] -> 2 CO2[c] + 2 MET[c] + PROTOPORPHYRINOGEN[c]
reaction name: Probable oxygen-independent coproporphyrinogen III oxidase
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2388c/hemN
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  COPROPORPHYRINOGEN_III[c] : coproporphyrinogen_III
  CO2[c] : carbon_dioxide
  MET[c] : methionine
  PROTOPORPHYRINOGEN[c] : protoporphyrinogen_IX

1.5 O2[c] + PROTOPORPHYRINOGEN[c] -> PROTOPORPHYRIN_IX[c]
reaction name: "Probable protoporphyrinogen oxidase, hemY or hemK"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2677c/hemY or Rv1300/hemK
metabolites:
  O2[c] : oxygen
  PROTOPORPHYRINOGEN[c] : protoporphyrinogen_IX
  PROTOPORPHYRIN_IX[c] : protoporphyrin_IX

FE2[c] + PROTOPORPHYRIN_IX[c] -> PROTOHEME_FE2[c]
reaction name: "ferrochelatase, hemZ"
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1485/hemH
metabolites:
  FE2[c] : ferrous iron
  PROTOPORPHYRIN_IX[c] : protoporphyrin_IX
  PROTOHEME_FE2[c] : protoheme

PROTOHEME_FE2[c] + FPP[c] -> PPI[c] + HEME_FE2[c]
reaction name: alkyl or aryl transferase
pathway: "Cofactor biosynthesis, heme biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  PROTOHEME_FE2[c] : protoheme
  FPP[c] : "trans, trans-farnesyl diphosphate"
  PPI[c] : pyrophosphate
  HEME_FE2[c] : heme-fe2

2 SAM[c] + UROPORPHYRINOGEN_III[c] -> 2 SAH[c] + PRECORIN[2][c]
reaction name: "Probable siroheme synthase, cysG2, OR possible uroporphyrin-III c-methyltransferase / Uroporphyrinogen-III synthase cysG"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2847c/cysG OR Rv0511/hemD
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  UROPORPHYRINOGEN_III[c] : uroporphyrinogen-III
  SAH[c] : S-adenosyl-L-homocysteine
  PRECORIN[2][c] : precorrin-2

SAM[c] + PRECORIN[2][c] -> SAH[c] + PRECORIN_3A[c]
reaction name: "Probable Precorrin-3B C17-methyltransferase / Precorrin-2 C20-methyltransferase, cobI/cobJ"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2066/cobI
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  PRECORIN[2][c] : precorrin-2
  SAH[c] : S-adenosyl-L-homocysteine
  PRECORIN_3A[c] : precorrin-3A

O2[c] + PRECORIN_3A[c] -> PRECORIN_3B[c]
reaction name: possible precorrin-3X synthase; CobG
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2064/cobG
metabolites:
  O2[c] : oxygen
  PRECORIN_3A[c] : precorrin-3A
  PRECORIN_3B[c] : precorrin-3B

SAM[c] + PRECORIN_3B[c] -> SAH[c] + PRECORIN_4B[c]
reaction name: "Precorrin-3B C17-methyltransferase / Precorrin-2 C20-methyltransferase, cobI"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2066/cobI
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  PRECORIN_3B[c] : precorrin-3B
  SAH[c] : S-adenosyl-L-homocysteine
  PRECORIN_4B[c] : precorrin-4B

SAM[c] + PRECORIN_4B[c] -> SAH[c] + PRECORIN[5][c]
reaction name: "Probable precorrin-3 methylase, cobM"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2071c/cobM
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  PRECORIN_4B[c] : precorrin-4B
  SAH[c] : S-adenosyl-L-homocysteine
  PRECORIN[5][c] : precorrin-5

SAM[c] + PRECORIN[5][c] -> AC[c] + SAH[c] + PRECORIN_6X[c]
reaction name: Precorrin-6A synthase (deacetylating).
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  PRECORIN[5][c] : precorrin-5
  AC[c] : acetate
  SAH[c] : S-adenosyl-L-homocysteine
  PRECORIN_6X[c] : precorrin-6x

2 H[c] + NADPH[c] + PRECORIN_6X[c] -> NADP[c] + PRECORIN_6Y[c]
reaction name: probable precorrin-6x reductase
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2070c/cobK
metabolites:
  H[c] : proton
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  PRECORIN_6X[c] : precorrin-6x
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  PRECORIN_6Y[c] : precorrin-6y

2 SAM[c] + PRECORIN_6Y[c] -> 3 H[c] + CO2[c] + 2 SAH[c] + PRECORIN_8X[c]
reaction name: " probable precorrin-6Y C5,15-methyltransferase (decarboxylating), cobl"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2072c/cobL
metabolites:
  SAM[c] : S-adenosyl-L-methionine
  PRECORIN_6Y[c] : precorrin-6y
  H[c] : proton
  CO2[c] : carbon_dioxide
  SAH[c] : S-adenosyl-L-homocysteine
  PRECORIN_8X[c] : precorrin-8x

PRECORIN_8X[c] -> HYDROGENOBYRINATE[c]
reaction name: "probable precorrin isomerase, cobH"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2065/cobH
metabolites:
  PRECORIN_8X[c] : precorrin-8x
  HYDROGENOBYRINATE[c] : hydrogenobyrinate

2 ATP[c] + 2 GLN[c] + HYDROGENOBYRINATE[c] -> 2 ADP[c] + 2 PI[c] + 2 GLU[c] + HYDROGENOBYRINATE_A_C_DIAMIDE[c]
reaction name: "probable cobyrinicacid a,c-diamide synthase , cobB"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2848c/cobB
metabolites:
  ATP[c] : adenosine-triphosphate
  GLN[c] : glutamine
  HYDROGENOBYRINATE[c] : hydrogenobyrinate
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  GLU[c] : glutamate
  HYDROGENOBYRINATE_A_C_DIAMIDE[c] : "hydrogenobyrinate_a,c_diamide"

ATP[c] + HYDROGENOBYRINATE_A_C_DIAMIDE[c] + CO_II[c] -> ADP[c] + PI[c] + COB_II_RINICACID_A_C_DIAMIDE[c]
reaction name: cobaltochelatase
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  ATP[c] : adenosine-triphosphate
  HYDROGENOBYRINATE_A_C_DIAMIDE[c] : "hydrogenobyrinate_a,c_diamide"
  CO_II[c] : Co2+ (cobalt ion)
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  COB_II_RINICACID_A_C_DIAMIDE[c] : "cob(II)yrinic acid a,c-diamide"

NADH[c] + COB_II_RINICACID_A_C_DIAMIDE[c] -> NAD[c] + COB_I_RINICACID_A_C_DIAMIDE[c]
reaction name: "cob(II)yrinic acid a,c-diamide reductase/oxidoreductase"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  COB_II_RINICACID_A_C_DIAMIDE[c] : "cob(II)yrinic acid a,c-diamide"
  NAD[c] : nicotinamide_adenine_dinucleotide
  COB_I_RINICACID_A_C_DIAMIDE[c] : "cob(I)yrinic acid a,c-diamide"

ATP[c] + COB_I_RINICACID_A_C_DIAMIDE[c] -> PPI[c] + ADENOSYL_COBRINICACID_A_C_DIAMIDE[c]
reaction name: "probable cob(i)alamin adenosyltransferase, cobA"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2849c/cobO
metabolites:
  ATP[c] : adenosine-triphosphate
  COB_I_RINICACID_A_C_DIAMIDE[c] : "cob(I)yrinic acid a,c-diamide"
  PPI[c] : pyrophosphate
  ADENOSYL_COBRINICACID_A_C_DIAMIDE[c] : "adenosyl-cobyrinic acid a,c-diamide"

4 ATP[c] + 4 GLN[c] + ADENOSYL_COBRINICACID_A_C_DIAMIDE[c] -> 4 ADP[c] + 4 PI[c] + 4 GLU[c] + ADENOSYL_COBRATE[c]
reaction name: "Probable cobyric acid synthase, cobQ"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0255c/cobQ1
metabolites:
  ATP[c] : adenosine-triphosphate
  GLN[c] : glutamine
  ADENOSYL_COBRINICACID_A_C_DIAMIDE[c] : "adenosyl-cobyrinic acid a,c-diamide"
  ADP[c] : adenosine-diphosphate
  PI[c] : phosphate
  GLU[c] : glutamate
  ADENOSYL_COBRATE[c] : adenosyl-cobyrate

1_AMINO_PROPAN_2_OL[c] + ADENOSYL_COBRATE[c] -> ADENOSYLCOBINAMIDE[c]
reaction name: "Possible cobC, aminotransferase."
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2231c/cobC
metabolites:
  1_AMINO_PROPAN_2_OL[c] : 1-amino-propan-2-ol
  ADENOSYL_COBRATE[c] : adenosyl-cobyrate
  ADENOSYLCOBINAMIDE[c] : adenosylcobinamide

ATP[c] + ADENOSYLCOBINAMIDE[c] -> ADP[c] + ADENOSYLCOBINIMIDE[P][c]
reaction name: "Probable cobinamide kinase, cobU"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0254c/cobU
metabolites:
  ATP[c] : adenosine-triphosphate
  ADENOSYLCOBINAMIDE[c] : adenosylcobinamide
  ADP[c] : adenosine-diphosphate
  ADENOSYLCOBINIMIDE[P][c] : adenosylcobinamide-P

GTP[c] + ADENOSYLCOBINIMIDE[P][c] -> PPI[c] + ADENOSYLCOBINAMIDE_GDP[c]
reaction name: adenosylcobinamide-phosphate guanylyltransferase
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  GTP[c] : guanosine-triphosphate
  ADENOSYLCOBINIMIDE[P][c] : adenosylcobinamide-P
  PPI[c] : pyrophosphate
  ADENOSYLCOBINAMIDE_GDP[c] : adenosylcobinamide-GDP

ADENOSYLCOBINAMIDE_GDP[c] -> COB[I][c] + GMP[c]
reaction name: "Probable cobalamin (5-phosphate) synthase, cobS"
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2208/cobS
metabolites:
  ADENOSYLCOBINAMIDE_GDP[c] : adenosylcobinamide-GDP
  COB[I][c] : coenzyme B12
  GMP[c] : guanosine-monophosphate

ARP[c] + ADENOSYLCOBINAMIDE_GDP[c] -> GMP[c] + ADOCBL[c]
reaction name: adenosylcobinamide-GDP ribazoletransferase
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  ARP[c] : -ribazole 5-phosphate
  ADENOSYLCOBINAMIDE_GDP[c] : adenosylcobinamide-GDP
  GMP[c] : guanosine-monophosphate
  ADOCBL[c] : adenosylcobalamin

ADOCBL[c] -> 2 H[c] + PI[c] + COB[I][c]
reaction name: adenosylcobalamin/alpha-ribazole-5-phosphate phosphohydrolase
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  ADOCBL[c] : adenosylcobalamin
  H[c] : proton
  PI[c] : phosphate
  COB[I][c] : coenzyme B12

NADH[c] + COB_II[c] <=> NAD[c] + COB[I][c]
reaction name: oxidoreductase
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  COB_II[c] : COB-II
  NAD[c] : nicotinamide_adenine_dinucleotide
  COB[I][c] : coenzyme B12

NADH[c] + COB_III[c] <=> NAD[c] + COB_II[c]
reaction name: oxidoreductase
pathway: "Cofactor biosynthesis, cobalamin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  COB_III[c] : COB-III
  NAD[c] : nicotinamide_adenine_dinucleotide
  COB_II[c] : COB-II

ATP[c] + CYS[c] + MOAD_COOH[c] -> PPI[c] + AMP[c] + SER[c] + MOAD_COSH[c]
reaction name: probably molybdopterin biosynthesis protein MoeB + cysteine desulfurase csdB
pathway: "Cofactor biosynthesis, molybdopterin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3206c/moeB1 AND Rv3025c/iscS
metabolites:
  ATP[c] : adenosine-triphosphate
  CYS[c] : L-cysteine
  MOAD_COOH[c] : moad-cooh
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  SER[c] : serine
  MOAD_COSH[c] : moad-cosh

GTP[c] -> PPI[c] + PRECURSOR[Z][c]
reaction name: probably precursor Z biosynthesis protein complex MoaABC
pathway: "Cofactor biosynthesis, molybdopterin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3109/moaA1 AND Rv3116/moeB2 AND Rv3111/moaC
metabolites:
  GTP[c] : guanosine-triphosphate
  PPI[c] : pyrophosphate
  PRECURSOR[Z][c] : precursor-Z

MOAD_COSH[c] + PRECURSOR[Z][c] -> MOAD_COOH[c] + MOLYBDOPTERIN[c]
reaction name: "probably molybdopterin biosynthesis protein, (moaE1 OR moaE2) large subunit 2 AND moaE3 small subunit"
pathway: "Cofactor biosynthesis, molybdopterin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3119/moaE1 OR Rv0866/moaE2 AND Rv3322c/-
metabolites:
  MOAD_COSH[c] : moad-cosh
  PRECURSOR[Z][c] : precursor-Z
  MOAD_COOH[c] : moad-cooh
  MOLYBDOPTERIN[c] : molybdopterin

MOLYBDOPTERIN[c] + MO2[c] -> MOLYBDENUM[c]
reaction name: "probably molybdopterin biosynthesis protein moeA1 OR moaA2, N-terminal region"
pathway: "Cofactor biosynthesis, molybdopterin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0994/moeA1 OR Rv0438c/moeA2
metabolites:
  MOLYBDOPTERIN[c] : molybdopterin
  MO2[c] : molybdenum_ion
  MOLYBDENUM[c] : molybdenum

GTP[c] + MOLYBDENUM[c] -> PPI[c] + MOLYBDOPTERIN_GDP[c]
reaction name: probable molybdopterin-guanine dinucleotide biosynthesis protein MobA
pathway: "Cofactor biosynthesis, molybdopterin biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2453c/mobA
metabolites:
  GTP[c] : guanosine-triphosphate
  MOLYBDENUM[c] : molybdenum
  PPI[c] : pyrophosphate
  MOLYBDOPTERIN_GDP[c] : molybdopterin_guanine_dinucleotide

TYR[c] -> TS_COSH_TYR[c]
reaction name: Hypothetical reaction
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  TYR[c] : tyrosine
  TS_COSH_TYR[c] : L-tyrosine/ThiS-COSH_complex

TS_PROTEIN[c] -> TS_COSH_TYR[c]
reaction name: Hypothetical reaction
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  TS_PROTEIN[c] : "ThiS_protein/C1of_Tyrosine,_4hydroxybenzyl_alcohol_complex"
  TS_COSH_TYR[c] : L-tyrosine/ThiS-COSH_complex

AIR[c] -> AHMMP[c]
reaction name: thiamine biosynthesis protein ThiC
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0423c/thiC
metabolites:
  AIR[c] : 5-aminoimidazole_ribonucleotide
  AHMMP[c] : hydroxymethylpyrimidine

ATP[c] + AHMMP[c] -> ADP[c] + AMPMP[c]
reaction name: PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0422c/thiD
metabolites:
  ATP[c] : adenosine-triphosphate
  AHMMP[c] : hydroxymethylpyrimidine
  ADP[c] : adenosine-diphosphate
  AMPMP[c] : hydroxymethylpyrimidine_phosphate

ATP[c] + AMPMP[c] -> ADP[c] + MAHMPPP[c]
reaction name: PROBABLE PHOSPHOMETHYLPYRIMIDINE KINASE THID
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0422c/thiD
metabolites:
  ATP[c] : adenosine-triphosphate
  AMPMP[c] : hydroxymethylpyrimidine_phosphate
  ADP[c] : adenosine-diphosphate
  MAHMPPP[c] : 4-amino-5-hydroxymethyl-2-methylpyrimidine-pyrophosphate

TS_COSH_TYR[c] + DX5P[c] -> TS_PROTEIN[c] + HEMT[c]
reaction name: PROBABLE THIAMIN BIOSYNTHESIS PROTEIN THIG
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0417/thiG
metabolites:
  TS_COSH_TYR[c] : L-tyrosine/ThiS-COSH_complex
  DX5P[c] : 1-deoxy-D-xylulose 5-phosphate
  TS_PROTEIN[c] : "ThiS_protein/C1of_Tyrosine,_4hydroxybenzyl_alcohol_complex"
  HEMT[c] : 4-methyl-5-(-hydroxyethyl)thiazole

ATP[c] + HEMT[c] -> ADP[c] + MPET[c]
reaction name: ATP:4-methyl-5-(2-hydroxyethyl)-thiazole 2-phosphotransferase
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  ATP[c] : adenosine-triphosphate
  HEMT[c] : 4-methyl-5-(-hydroxyethyl)thiazole
  ADP[c] : adenosine-diphosphate
  MPET[c] : 4-methyl-5-(-hydroxyethyl)thiazole_phosphate

MAHMPPP[c] + MPET[c] -> PPI[c] + THIP[c]
reaction name: "2-methyl-4-aminopyridine-5-methenyltransferase, thiE"
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0414c/thiE
metabolites:
  MAHMPPP[c] : 4-amino-5-hydroxymethyl-2-methylpyrimidine-pyrophosphate
  MPET[c] : 4-methyl-5-(-hydroxyethyl)thiazole_phosphate
  PPI[c] : pyrophosphate
  THIP[c] : thiamine-phosphate

THIP[c] -> PI[c] + THI[c]
reaction name:
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  THIP[c] : thiamine-phosphate
  PI[c] : phosphate
  THI[c] : thiamine

THI[c] -> AHMMP[c] + HEMT[c]
reaction name: Thiamin hydrolase
pathway: "Cofactor biosynthesis, Thiamine biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  THI[c] : thiamine
  AHMMP[c] : hydroxymethylpyrimidine
  HEMT[c] : 4-methyl-5-(-hydroxyethyl)thiazole

GTP[c] + LLAC[c] -> GDP[c] + 2_PHOSPHO_L_LACTATE[c]
reaction name:
pathway: "Cofactor biosynthesis, F420 biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  GTP[c] : guanosine-triphosphate
  LLAC[c] : lactate
  GDP[c] : guanosine_diphosphate
  2_PHOSPHO_L_LACTATE[c] : 2-phospho-L-lactate

GTP[c] + 2_PHOSPHO_L_LACTATE[c] -> PPI[c] + LPPG[c]
reaction name:
pathway: "Cofactor biosynthesis, F420 biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  GTP[c] : guanosine-triphosphate
  2_PHOSPHO_L_LACTATE[c] : 2-phospho-L-lactate
  PPI[c] : pyrophosphate
  LPPG[c] : LPPG

4HPP[c] + A6RP[c] -> NH3[c] + FO[c]
reaction name: "F420 biosynthesis protein, FbiC: Lactyl (2) diphospho-(5)guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lacta... "
pathway: "Cofactor biosynthesis, F420 biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1173/fbiC
metabolites:
  4HPP[c] : p-hydroxyphenylpyruvate
  A6RP[c] : 5-amino-6-(5-phosphoribosylamino)uracil
  NH3[c] : ammonia
  FO[c] : FO

LPPG[c] + FO[c] -> GMP[c] + F420[0][c]
reaction name: "F420 biosynthesis proteins, Fbia AND FbiB: Coenzyme F420-0:L-glutamate ligase"
pathway: "Cofactor biosynthesis, F420 biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3261/fbiA AND Rv3262/fbiB
metabolites:
  LPPG[c] : LPPG
  FO[c] : FO
  GMP[c] : guanosine-monophosphate
  F420[0][c] : F420-0

5 ATP[c] + 5 GLU[c] + F420[0][c] -> F420[c]
reaction name: "F420 biosynthesis proteins, Fbia AND FbiB: Coenzyme F420-0:L-glutamate ligase"
pathway: "Cofactor biosynthesis, F420 biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv3261/fbiA AND Rv3263/-
metabolites:
  ATP[c] : adenosine-triphosphate
  GLU[c] : glutamate
  F420[0][c] : F420-0
  F420[c] : coenzyme F420

IP[c] + UDPNAG[c] -> PI[c] + UDP[c] + NAG_INS[c]
reaction name: "glycosyltransferase, mshA"
pathway: "Cofactor biosynthesis, mycothiol biosynthesis - hyothetical reaction"
subsystem: Cofactor biosynthesis
enzymes: Rv0486/-
metabolites:
  IP[c] : inositol_phosphate
  UDPNAG[c] : UDP-N-acetyl-D-glucosamine
  PI[c] : phosphate
  UDP[c] : uridine-diphosphate
  NAG_INS[c] : 1-D-myo-inosityl-2-acetamido-2-deoxy--D-glucopyranoside

NAG_INS[c] -> AC[c] + NG_INS[c]
reaction name: "N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-?-D-glucopyranoside deacetylase, mshB "
pathway: "Cofactor biosynthesis, mycothiol biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1170/mshB
metabolites:
  NAG_INS[c] : 1-D-myo-inosityl-2-acetamido-2-deoxy--D-glucopyranoside
  AC[c] : acetate
  NG_INS[c] : glucosaminyl-inositol

ATP[c] + CYS[c] + NG_INS[c] -> PPI[c] + AMP[c] + CYS_NG_INS[c]
reaction name: "L-cysteine:1 D-myo-inositol 2-amino-2-deoxy-?-D-glucopyranoside ligase, mshC"
pathway: "Cofactor biosynthesis, mycothiol biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv2130c/cysS
metabolites:
  ATP[c] : adenosine-triphosphate
  CYS[c] : L-cysteine
  NG_INS[c] : glucosaminyl-inositol
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  CYS_NG_INS[c] : desacetylmycothiol_(1-D-myo-inosityl-2-(L-cysteinyl)amido-2-deoxy--D-glucopyranoside)

ACCOA[c] + CYS_NG_INS[c] -> COA[c] + MYCOTHIOL[c]
reaction name: "mycothiol synthase, mshD"
pathway: "Cofactor biosynthesis, mycothiol biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv0819/-
metabolites:
  ACCOA[c] : acetyl-CoA
  CYS_NG_INS[c] : desacetylmycothiol_(1-D-myo-inosityl-2-(L-cysteinyl)amido-2-deoxy--D-glucopyranoside)
  COA[c] : coenzyme_A
  MYCOTHIOL[c] : mycothiol

MYCOTHIOL[c] + ELECTROPHILE[X][c] -> H2X[c] + MYCOTHIOL_S_CONJUGATE[c]
reaction name: mycothiol oxidation
pathway: "Cofactor biosynthesis, mycothiol biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: orphan
metabolites:
  MYCOTHIOL[c] : mycothiol
  ELECTROPHILE[X][c] : electrophile-x
  H2X[c] : H2X
  MYCOTHIOL_S_CONJUGATE[c] : mycothiol-s-conjugate

MYCOTHIOL_S_CONJUGATE[c] -> 0.999 NG_INS[c] + N_ACETYL_S_CONJUGATE[c]
reaction name: "mycothiol conjugate amidase, mca"
pathway: "Cofactor biosynthesis, mycothiol biosynthesis"
subsystem: Cofactor biosynthesis
enzymes: Rv1082/mca
metabolites:
  MYCOTHIOL_S_CONJUGATE[c] : mycothiol-s-conjugate
  NG_INS[c] : glucosaminyl-inositol
  N_ACETYL_S_CONJUGATE[c] : n-acetyl-s-conjugate

ICHOR[c] -> PYR[c] + SAL[c]
reaction name: isochorismate pyruvate-lyase
pathway: mycobactin synthesis
subsystem: Other
enzymes: orphan
metabolites:
  ICHOR[c] : isochorismate
  PYR[c] : pyruvate
  SAL[c] : salicylate

2 COA[c] -> MBT_HOLO[c]
reaction name: phosphopantetheinyl transferase
pathway: mycobactin synthesis
subsystem: Other
enzymes: Rv2523c/acpS
metabolites:
  COA[c] : coenzyme_A
  MBT_HOLO[c] : mycobactinF-HOLO

ATP[c] + SAL[c] + MBT_HOLO[c] -> PPI[c] + AMP[c] + MBTA_SAL[c]
reaction name: peptide arylase
pathway: mycobactin synthesis
subsystem: Other
enzymes: Rv2384/mbtA
metabolites:
  ATP[c] : adenosine-triphosphate
  SAL[c] : salicylate
  MBT_HOLO[c] : mycobactinF-HOLO
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  MBTA_SAL[c] : mycobactinA-SAL

ATP[c] + SER[c] + MBT_HOLO[c] -> PPI[c] + AMP[c] + MBTB_SER[c]
reaction name: "peptide synthetase, mbtB"
pathway: mycobactin synthesis
subsystem: Other
enzymes: Rv2383c/mbtB
metabolites:
  ATP[c] : adenosine-triphosphate
  SER[c] : serine
  MBT_HOLO[c] : mycobactinF-HOLO
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  MBTB_SER[c] : mycobactinB-SER

ATP[c] + LYS[c] + MBT_HOLO[c] -> PPI[c] + AMP[c] + MBTE_LYS[c]
reaction name: peptide synthetase
pathway: mycobactin synthesis
subsystem: Other
enzymes: Rv2380c/mbtE
metabolites:
  ATP[c] : adenosine-triphosphate
  LYS[c] : L-lysine
  MBT_HOLO[c] : mycobactinF-HOLO
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  MBTE_LYS[c] : mycobactinE-LYS

ATP[c] + LYS[c] + MBT_HOLO[c] -> PPI[c] + AMP[c] + MBTF_LYS[c]
reaction name: peptide synthetase
pathway: mycobactin synthesis
subsystem: Other
enzymes: Rv2380c/mbtE
metabolites:
  ATP[c] : adenosine-triphosphate
  LYS[c] : L-lysine
  MBT_HOLO[c] : mycobactinF-HOLO
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  MBTF_LYS[c] : mycobactinF-LYS

ACCOA[c] + MBT_HOLO[c] + MALCOA[c] -> 2 COA[c] + MBTCD_HBA[c]
reaction name: "polyketide synthase mbtC, mbtD"
pathway: mycobactin synthesis
subsystem: Other
enzymes: Rv2382c/mbtC AND Rv2381c/mbtD
metabolites:
  ACCOA[c] : acetyl-CoA
  MBT_HOLO[c] : mycobactinF-HOLO
  MALCOA[c] : malonyl-CoA
  COA[c] : coenzyme_A
  MBTCD_HBA[c] : mycobactinCD-HBA

MBTA_SAL[c] + MBTB_SER[c] + MBTE_LYS[c] + MBTF_LYS[c] + MBTCD_HBA[c] -> 5 MBT_HOLO[c] + MBT[c]
reaction name:
pathway: mycobactin synthesis
subsystem: Other
enzymes: orphan
metabolites:
  MBTA_SAL[c] : mycobactinA-SAL
  MBTB_SER[c] : mycobactinB-SER
  MBTE_LYS[c] : mycobactinE-LYS
  MBTF_LYS[c] : mycobactinF-LYS
  MBTCD_HBA[c] : mycobactinCD-HBA
  MBT_HOLO[c] : mycobactinF-HOLO
  MBT[c] : mycobactin

2 NADPH[c] + 2 ACCOA[c] + MBT[c] -> 2 NADP[c] + 2 COA[c] + MBTSEC[c]
reaction name: acyl transferase - hypothetical reaction
pathway: mycobactin synthesis
subsystem: Other
enzymes: orphan
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACCOA[c] : acetyl-CoA
  MBT[c] : mycobactin
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  COA[c] : coenzyme_A
  MBTSEC[c] : mycobactinSEC

18 NADPH[c] + 9 ACCOA[c] + MBT[c] -> 18 NADP[c] + 9 COA[c] + MBTWALL[c]
reaction name: acyl transferase - hypothetical reaction
pathway: mycobactin synthesis
subsystem: Other
enzymes: orphan
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACCOA[c] : acetyl-CoA
  MBT[c] : mycobactin
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  COA[c] : coenzyme_A
  MBTWALL[c] : mycobactinWALL

ACCOA[c] + BIOTIN_CO2[c] -> 0.999 BIOTIN[c] + MALCOA[c]
reaction name: "acetyl-CoA/propionyl-CoA carboxylase carboxytransferase subunit: 6 paralogues in Mtb: accD1, accD2, accD3, accD4, accD5, accD6"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv0904c/accD3 OR Rv2502c/accD1 OR Rv0974c/accD2 OR Rv0904c/accD3 OR Rv3799c/accD4 OR Rv3280/accD5 OR Rv2247/accD6
metabolites:
  ACCOA[c] : acetyl-CoA
  BIOTIN_CO2[c] : BCCP-biotin-CO2
  BIOTIN[c] : biotin
  MALCOA[c] : malonyl-CoA

ACCOA[c] + ACP[c] <=> COA[c] + ACACP[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  ACCOA[c] : acetyl-CoA
  ACP[c] : acyl-carrier-protein
  COA[c] : coenzyme_A
  ACACP[c] : acetyl-ACP

4 NADPH[c] + ACACP[c] + 2 MALACP[c] -> 4 NADP[c] + 2 CO2[c] + 2 ACP[c] + HEXANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  HEXANOYL_ACP[c] : hexanoyl-ACP

8 NADPH[c] + ACACP[c] + 4 MALACP[c] -> 8 NADP[c] + 4 CO2[c] + 4 ACP[c] + OCTANOYL_ACP[c]
reaction name:
pathway:
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  OCTANOYL_ACP[c] : octanoyl-acp

12 NADPH[c] + ACACP[c] + 6 MALACP[c] -> 12 NADP[c] + 6 CO2[c] + 6 ACP[c] + TETRADECANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  TETRADECANOYL_ACP[c] : tetradecanoyl-ACP

14 NADPH[c] + ACACP[c] + 7 MALACP[c] -> 14 NADP[c] + 7 CO2[c] + 7 ACP[c] + HEXADECANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  HEXADECANOYL_ACP[c] : hexadecanoyl-ACP

13 NADPH[c] + ACACP[c] + 7 MALACP[c] -> 13 NADP[c] + 7 CO2[c] + 7 ACP[c] + 9_HEXADECENOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  9_HEXADECENOYL_ACP[c] : 9-hexadecenoyl-ACP

16 NADPH[c] + ACACP[c] + 8 MALACP[c] -> 16 NADP[c] + 8 CO2[c] + 8 ACP[c] + OCTADECANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  OCTADECANOYL_ACP[c] : octadecanoyl-ACP

15 NADPH[c] + ACACP[c] + 8 MALACP[c] -> 15 NADP[c] + 8 CO2[c] + 8 ACP[c] + 9_OCTADECENOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  9_OCTADECENOYL_ACP[c] : 9-octadecenoyl-ACP

18 NADPH[c] + ACACP[c] + 9 MALACP[c] -> 18 NADP[c] + 9 CO2[c] + 9 ACP[c] + EICOSANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  EICOSANOYL_ACP[c] : eicosanoyl-ACP

20 NADPH[c] + ACACP[c] + 10 MALACP[c] -> 20 NADP[c] + 10 CO2[c] + 10 ACP[c] + DOCOSANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  DOCOSANOYL_ACP[c] : docosanoyl-ACP

22 NADPH[c] + ACACP[c] + 11 MALACP[c] -> 22 NADP[c] + 11 CO2[c] + 11 ACP[c] + TETRACOSANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  TETRACOSANOYL_ACP[c] : tetracosanoyl-ACP

24 NADPH[c] + ACACP[c] + 12 MALACP[c] -> 24 NADP[c] + 12 CO2[c] + 12 ACP[c] + HEXACOSANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  HEXACOSANOYL_ACP[c] : hexacosanoyl-ACP

26 NADPH[c] + ACACP[c] + 13 MALACP[c] -> 26 NADP[c] + 13 CO2[c] + 13 ACP[c] + OCTACOSANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  ACACP[c] : acetyl-ACP
  MALACP[c] : malonyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  OCTACOSANOYL_ACP[c] : octacosanoyl-ACP

BIOTIN_CO2[c] + HEXACOSANOYL_COA[c] -> BIOTIN[c] + HEXACOSANOYL_COA_CO2[c]
reaction name: "hexacosanoyl-CoA carboxylase, accA3, accD4 and accD5"
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv3280/accD5 AND Rv3799c/accD4 AND Rv3285/accA3
metabolites:
  BIOTIN_CO2[c] : BCCP-biotin-CO2
  HEXACOSANOYL_COA[c] : hexacosanoyl-CoA
  BIOTIN[c] : biotin
  HEXACOSANOYL_COA_CO2[c] : hexacosanoyl-CoA-CO2

COA[c] + HEXANOYL_ACP[c] <=> ACP[c] + HEXANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  HEXANOYL_ACP[c] : hexanoyl-ACP
  ACP[c] : acyl-carrier-protein
  HEXANOYL_COA[c] : hexanoyl-CoA

COA[c] + TETRADECANOYL_ACP[c] <=> ACP[c] + TETRADECANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  TETRADECANOYL_ACP[c] : tetradecanoyl-ACP
  ACP[c] : acyl-carrier-protein
  TETRADECANOYL_COA[c] : tetradecanoyl-CoA

COA[c] + HEXADECANOYL_ACP[c] <=> ACP[c] + HEXADECANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  HEXADECANOYL_ACP[c] : hexadecanoyl-ACP
  ACP[c] : acyl-carrier-protein
  HEXADECANOYL_COA[c] : hexadecanoyl-COA

COA[c] + 9_HEXADECENOYL_ACP[c] <=> ACP[c] + 9_HEXADECENOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  9_HEXADECENOYL_ACP[c] : 9-hexadecenoyl-ACP
  ACP[c] : acyl-carrier-protein
  9_HEXADECENOYL_COA[c] : 9-hexadecenoyl-CoA

COA[c] + OCTADECANOYL_ACP[c] <=> ACP[c] + OCTADECANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  OCTADECANOYL_ACP[c] : octadecanoyl-ACP
  ACP[c] : acyl-carrier-protein
  OCTADECANOYL_COA[c] : octadecanoyl-CoA

COA[c] + 9_OCTADECENOYL_ACP[c] <=> ACP[c] + 9_OCTADECENOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  9_OCTADECENOYL_ACP[c] : 9-octadecenoyl-ACP
  ACP[c] : acyl-carrier-protein
  9_OCTADECENOYL_COA[c] : 9-octadecenoyl-CoA

COA[c] + EICOSANOYL_ACP[c] <=> ACP[c] + EICOSANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  EICOSANOYL_ACP[c] : eicosanoyl-ACP
  ACP[c] : acyl-carrier-protein
  EICOSANOYL_COA[c] : eicosanoyl-CoA

COA[c] + DOCOSANOYL_ACP[c] <=> ACP[c] + DOCOSANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  DOCOSANOYL_ACP[c] : docosanoyl-ACP
  ACP[c] : acyl-carrier-protein
  DOCOSANOYL_COA[c] : docosanoyl-CoA

COA[c] + TETRACOSANOYL_ACP[c] <=> ACP[c] + TETRACOSANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  TETRACOSANOYL_ACP[c] : tetracosanoyl-ACP
  ACP[c] : acyl-carrier-protein
  TETRACOSANOYL_COA[c] : tetracosanoyl-CoA

COA[c] + HEXACOSANOYL_ACP[c] <=> ACP[c] + HEXACOSANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  HEXACOSANOYL_ACP[c] : hexacosanoyl-ACP
  ACP[c] : acyl-carrier-protein
  HEXACOSANOYL_COA[c] : hexacosanoyl-CoA

COA[c] + OCTACOSANOYL_ACP[c] <=> ACP[c] + OCTACOSANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  OCTACOSANOYL_ACP[c] : octacosanoyl-ACP
  ACP[c] : acyl-carrier-protein
  OCTACOSANOYL_COA[c] : octacosanoyl-COA

COA[c] + NONADECANOYL_ACP[c] <=> ACP[c] + NONADECANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  NONADECANOYL_ACP[c] : nonadecanoyl-ACP
  ACP[c] : acyl-carrier-protein
  NONADECANOYL_COA[c] : nonadecanoyl-COA

COA[c] + HEPTADECANOYL_ACP[c] <=> ACP[c] + HEPTADECANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  HEPTADECANOYL_ACP[c] : heptadecanoyl-ACP
  ACP[c] : acyl-carrier-protein
  HEPTADECANOYL_COA[c] : heptadecanoyl-CoA

COA[c] + PENTADECANOYL_ACP[c] <=> ACP[c] + PENTADECANOYL_COA[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, pathway 1"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  COA[c] : coenzyme_A
  PENTADECANOYL_ACP[c] : pentadecanoyl-ACP
  ACP[c] : acyl-carrier-protein
  PENTADECANOYL_COA[c] : pentadecanoyl-CoA

PROPIONYLCOA[c] + ACP[c] -> COA[c] + PROPIONYLACP[c]
reaction name: transacylase fabD or fabD2 and acyl carrier protein AcpM
pathway: "lipid biosynthesis, odd numbered fatty acids"
subsystem: Lipid biosyntheis
enzymes: Rv2243/fabD OR Rv0649/fabD2 AND Rv2244/acpP
metabolites:
  PROPIONYLCOA[c] : propionyl-CoA
  ACP[c] : acyl-carrier-protein
  COA[c] : coenzyme_A
  PROPIONYLACP[c] : propionyl-ACP

12 NADPH[c] + 6 MALACP[c] + PROPIONYLACP[c] -> 12 NADP[c] + 6 CO2[c] + 6 ACP[c] + PENTADECANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, odd numbered fatty acids"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  MALACP[c] : malonyl-ACP
  PROPIONYLACP[c] : propionyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  PENTADECANOYL_ACP[c] : pentadecanoyl-ACP

2 NADPH[c] + MALACP[c] + PENTADECANOYL_ACP[c] -> 2 NADP[c] + CO2[c] + ACP[c] + HEPTADECANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, odd numbered fatty acids"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  MALACP[c] : malonyl-ACP
  PENTADECANOYL_ACP[c] : pentadecanoyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  HEPTADECANOYL_ACP[c] : heptadecanoyl-ACP

2 NADPH[c] + MALACP[c] + HEPTADECANOYL_ACP[c] -> 2 NADP[c] + CO2[c] + ACP[c] + NONADECANOYL_ACP[c]
reaction name: "fatty acid synthase, FAS-1"
pathway: "lipid biosynthesis, odd numbered fatty acids"
subsystem: Lipid biosyntheis
enzymes: Rv2524c/fas
metabolites:
  NADPH[c] : Nicotinamide_adenine_dinucleotide_phosphate_-_reduced
  MALACP[c] : malonyl-ACP
  HEPTADECANOYL_ACP[c] : heptadecanoyl-ACP
  NADP[c] : nicotinamide_adenine_dinucleotide_phosphate
  CO2[c] : carbon_dioxide
  ACP[c] : acyl-carrier-protein
  NONADECANOYL_ACP[c] : nonadecanoyl-ACP

ATP[c] + COA[c] + HEXANOATE[c] -> PPI[c] + AMP[c] + HEXANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  HEXANOATE[c] : hexanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  HEXANOYL_COA[c] : hexanoyl-CoA

ATP[c] + COA[c] + DECANOATE[c] -> PPI[c] + AMP[c] + DECANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  DECANOATE[c] : decanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  DECANOYL_COA[c] : decanoyl-CoA

ATP[c] + COA[c] + DODECANOATE[c] -> PPI[c] + AMP[c] + DODECANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  DODECANOATE[c] : dodecanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  DODECANOYL_COA[c] : dodecanoyl-CoA

ATP[c] + COA[c] + TETRADECANOATE[c] -> PPI[c] + AMP[c] + TETRADECANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  TETRADECANOATE[c] : tetradecanoate_
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  TETRADECANOYL_COA[c] : tetradecanoyl-CoA

ATP[c] + COA[c] + HEXADECANOATE[c] -> PPI[c] + AMP[c] + HEXADECANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  HEXADECANOATE[c] : hexadecanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  HEXADECANOYL_COA[c] : hexadecanoyl-COA

ATP[c] + COA[c] + 9_HEXADECENOATE[c] -> PPI[c] + AMP[c] + 9_HEXADECENOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  9_HEXADECENOATE[c] : 9-hexadecenoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  9_HEXADECENOYL_COA[c] : 9-hexadecenoyl-CoA

ATP[c] + COA[c] + OCTADECANOATE[c] -> PPI[c] + AMP[c] + OCTADECANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  OCTADECANOATE[c] : octadecanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  OCTADECANOYL_COA[c] : octadecanoyl-CoA

ATP[c] + COA[c] + 9_OCTADECENOATE[c] -> PPI[c] + AMP[c] + 9_OCTADECENOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  9_OCTADECENOATE[c] : 9-octadecenoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  9_OCTADECENOYL_COA[c] : 9-octadecenoyl-CoA

ATP[c] + COA[c] + EICOSANOATE[c] -> PPI[c] + AMP[c] + EICOSANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  EICOSANOATE[c] : eicosanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  EICOSANOYL_COA[c] : eicosanoyl-CoA

ATP[c] + COA[c] + DOCOSANOATE[c] -> PPI[c] + AMP[c] + DOCOSANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  DOCOSANOATE[c] : docosanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  DOCOSANOYL_COA[c] : docosanoyl-CoA

ATP[c] + COA[c] + TETRACOSANOATE[c] -> PPI[c] + AMP[c] + TETRACOSANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  TETRACOSANOATE[c] : tetracosanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  TETRACOSANOYL_COA[c] : tetracosanoyl-CoA

ATP[c] + COA[c] + HEXACOSANOATE[c] -> PPI[c] + AMP[c] + HEXACOSANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  HEXACOSANOATE[c] : hexacosanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  HEXACOSANOYL_COA[c] : hexacosanoyl-CoA

ATP[c] + COA[c] + PENTADECANOATE[c] -> PPI[c] + AMP[c] + PENTADECANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  PENTADECANOATE[c] : pentadecanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  PENTADECANOYL_COA[c] : pentadecanoyl-CoA

ATP[c] + COA[c] + HEPTADECANOATE[c] -> PPI[c] + AMP[c] + HEPTADECANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  HEPTADECANOATE[c] : heptadecanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  HEPTADECANOYL_COA[c] : heptadecanoyl-CoA

ATP[c] + COA[c] + NONADECANOATE[c] -> PPI[c] + AMP[c] + NONADECANOYL_COA[c]
reaction name: fadD1 - fadD34
pathway: acylCoA synthases
subsystem: Lipid biosyntheis
enzymes: Rv0035/fadD34 OR Rv0099/fadD10 OR Rv0119/fadD7 OR Rv0166/fadD5 OR Rv0214/fadD4 OR Rv0270/fadD2 OR Rv0275c/- OR Rv0404/fadD30 OR Rv0551c/fadD8 OR Rv0852/fadD16 OR Rv1058/fadD14 OR Rv1185c/fadD21 OR Rv119.../-
metabolites:
  ATP[c] : adenosine-triphosphate
  COA[c] : coenzyme_A
  NONADECANOATE[c] : nonadecanoate
  PPI[c] : pyrophosphate
  AMP[c] : adenosine-monophosphate
  NONADECANOYL_COA[c] : nonadecanoyl-COA

NAD[c] + COA[c] + FAD[c] + OCTACOSANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + HEXACOSANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  OCTACOSANOYL_COA[c] : octacosanoyl-COA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  HEXACOSANOYL_COA[c] : hexacosanoyl-CoA

NAD[c] + COA[c] + FAD[c] + HEXACOSANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + TETRACOSANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  HEXACOSANOYL_COA[c] : hexacosanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  TETRACOSANOYL_COA[c] : tetracosanoyl-CoA

NAD[c] + COA[c] + FAD[c] + TETRACOSANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + DOCOSANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  TETRACOSANOYL_COA[c] : tetracosanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  DOCOSANOYL_COA[c] : docosanoyl-CoA

NAD[c] + COA[c] + FAD[c] + DOCOSANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + EICOSANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  DOCOSANOYL_COA[c] : docosanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  EICOSANOYL_COA[c] : eicosanoyl-CoA

NAD[c] + COA[c] + FAD[c] + EICOSANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + OCTADECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  EICOSANOYL_COA[c] : eicosanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  OCTADECANOYL_COA[c] : octadecanoyl-CoA

NAD[c] + COA[c] + FAD[c] + OCTADECANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + HEXADECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  OCTADECANOYL_COA[c] : octadecanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  HEXADECANOYL_COA[c] : hexadecanoyl-COA

NAD[c] + COA[c] + FAD[c] + HEXADECANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + TETRADECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  HEXADECANOYL_COA[c] : hexadecanoyl-COA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  TETRADECANOYL_COA[c] : tetradecanoyl-CoA

NAD[c] + COA[c] + FAD[c] + TETRADECANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + DODECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  TETRADECANOYL_COA[c] : tetradecanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  DODECANOYL_COA[c] : dodecanoyl-CoA

NAD[c] + COA[c] + FAD[c] + DODECANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + DECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  DODECANOYL_COA[c] : dodecanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  DECANOYL_COA[c] : decanoyl-CoA

NAD[c] + COA[c] + FAD[c] + DECANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + OCTANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  DECANOYL_COA[c] : decanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  OCTANOYL_COA[c] : octanoyl-coa

NAD[c] + COA[c] + FAD[c] + OCTANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + HEXANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  OCTANOYL_COA[c] : octanoyl-coa
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  HEXANOYL_COA[c] : hexanoyl-CoA

NAD[c] + COA[c] + FAD[c] + HEXANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + BUTANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  HEXANOYL_COA[c] : hexanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  BUTANOYL_COA[c] : butanoyl-CoA

NAD[c] + COA[c] + FAD[c] + BUTANOYL_COA[c] -> NADH[c] + 2 ACCOA[c] + FADH2[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  BUTANOYL_COA[c] : butanoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced

NAD[c] + COA[c] + FAD[c] + 9_OCTADECENOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + 9_HEXADECENOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of unsaturated fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  9_OCTADECENOYL_COA[c] : 9-octadecenoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  9_HEXADECENOYL_COA[c] : 9-hexadecenoyl-CoA

NAD[c] + COA[c] + FAD[c] + 9_HEXADECENOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + CIS_DELTA_5_TETRADECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of unsaturated fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  9_HEXADECENOYL_COA[c] : 9-hexadecenoyl-CoA
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  CIS_DELTA_5_TETRADECANOYL_COA[c] : cis-delta-5-tetradecanoyl-coa

NAD[c] + COA[c] + FAD[c] + CIS_DELTA_5_TETRADECANOYL_COA[c] -> NADH[c] + ACCOA[c] + FADH2[c] + CIS_DELTA_3_DODECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of unsaturated fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  COA[c] : coenzyme_A
  FAD[c] : flavin adenine dinucleotide
  CIS_DELTA_5_TETRADECANOYL_COA[c] : cis-delta-5-tetradecanoyl-coa
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  ACCOA[c] : acetyl-CoA
  FADH2[c] : flavin adenine dinucleotide reduced
  CIS_DELTA_3_DODECANOYL_COA[c] : cis-delta-3-dodecanoyl-coa

CIS_DELTA_3_DODECANOYL_COA[c] -> TRANS_DELTA_2_DODECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of unsaturated fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  CIS_DELTA_3_DODECANOYL_COA[c] : cis-delta-3-dodecanoyl-coa
  TRANS_DELTA_2_DODECANOYL_COA[c] : trans-delta-2-dodecanoyl-coa

TRANS_DELTA_2_DODECANOYL_COA[c] -> TRANS_DELTA_2_HYDROXY_DODECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of unsaturated fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  TRANS_DELTA_2_DODECANOYL_COA[c] : trans-delta-2-dodecanoyl-coa
  TRANS_DELTA_2_HYDROXY_DODECANOYL_COA[c] : trans-delta-2-hydroxy-dodecanoyl-coa

NAD[c] + TRANS_DELTA_2_HYDROXY_DODECANOYL_COA[c] -> NADH[c] + DODECANOYL_COA[c]
reaction name: acyl-CoA dehydrogenase fadE1-36 AND enoyl-CoA hydratase/isomerase echA1-21 AND 3-hydroxyacyl-CoA dehydrogenase fadB2-5 AND acety...
pathway: beta oxidation of unsaturated fatty acids
subsystem: beta oxidation of fatty acids
enzymes: Rv0131c/fadE1 OR Rv0154c/fadE2 OR Rv0215c/fadE3 OR Rv0231/fadE4 OR Rv0244c/fadE5 OR Rv0271c/fadE6 OR Rv0400c/fadE7 OR Rv0752c/fadE9 OR Rv0873/fadE10 OR Rv0972c/fadE12 OR Rv0975c/fadE13 OR Rv1346/fadE14 OR...
metabolites:
  NAD[c] : nicotinamide_adenine_dinucleotide
  TRANS_DELTA_2_HYDROXY_DODECANOYL_COA[c] : trans-delta-2-hydroxy-dodecanoyl-coa
  NADH[c] : nicotinamide_adenine_dinucleotide_-_reduced
  DODECANOYL_COA[c] : dodecanoyl-CoA

PA[c] -> PI[c] + DAG[c]
reaction name: phosphatidic acid phosphatase
pathway: "Acylglycerol synthesis, Diacylglycerol synthesis"
subsystem: Lipid biosyntheis
enzymes: orphan
metabolites:
  PA[c] : L-phosphatidate
  PI[c] : phosphate
  DAG[c] : "1,2-diacylglycerol"