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M. thermoresistible (build 8) TH_4466 (-)

annotation: conserved hypothetical proline and threonine rich protein
coordinates: 2478374 - 2479687
length: 438

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4466--100% (438)conserved hypothetical proline and threonine rich protein
M. thermoresistible (build 8)TH_1245-8e-8448.01% (352) conserved hypothetical proline rich protein
M. thermoresistible (build 8)TH_3857-1e-7550.62% (322) PUTATIVE putative conserved hypothetical proline rich protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0320-1e-7846.78% (357) hypothetical protein Mb0320
M. gilvum PYR-GCKMflv_0276-1e-12764.45% (346) hypothetical protein Mflv_0276
M. tuberculosis H37RvRv0312-7e-7846.50% (357) hypothetical protein Rv0312
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4291-6e-8949.72% (356) hypothetical protein MAB_4291
M. marinum MMMAR_0617-4e-8642.96% (433) hypothetical protein MMAR_0617
M. avium 104MAV_4816-2e-8147.13% (348) hypothetical protein MAV_4816
M. smegmatis MC2 155MSMEG_0692-1e-12766.19% (349) hypothetical protein MSMEG_0692
M. ulcerans Agy99MUL_0582-3e-8843.65% (433) hypothetical protein MUL_0582
M. vanbaalenii PYR-1Mvan_0621-1e-12861.06% (398) hypothetical protein Mvan_0621

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_0276|M.gilvum_PYR-GCK          ---MTEPLGLSIGTTNLVAARVG--RPPVTRRAILTLVAGQAPQVGTPEE
Mvan_0621|M.vanbaalenii_PYR-1       ---MTEPLGLSIGMTNLVAARVG--RPPVTRRSILNLYTDRAPEVGAPSE
MSMEG_0692|M.smegmatis_MC2_155      ---MTDSLGLSIGITNLVAAREG--RAPVVRRSILNLYRDRAPEVG---E
TH_4466|M.thermoresistible__bu      ---MTDPLGLSVGMTNLVAARIG--QPPVLRRAVLTMFGDRPPEVGVPDP
MMAR_0617|M.marinum_M               ---MSESLGLSIGVANLVATRAG--GAPLRRASVLHLFQHQAAEVGLPEE
MUL_0582|M.ulcerans_Agy99           MWDMSESLGLSIGVANLVATRAG--GAPLRRASVLHLFQHQAAEVGLPEE
MAV_4816|M.avium_104                MRDMSEPLGLSIGVANLVAARAG--SVPVIRSSVLTLFEQRPTEVGLPDE
MAB_4291|M.abscessus_ATCC_1997      ---MANALGLSIGATQLVATPDDPQSQPVVRSSILTLHEDGPPEVGVPSQ
Mb0320|M.bovis_AF2122/97            ---MYDPLGLSIGTTNLVAAGNG--GPPVTRRAVLTLYPHCAPKIGVPSQ
Rv0312|M.tuberculosis_H37Rv         ---MYDPLGLSIGTTNLVAAGNG--GPPVTRRAVLTLYPHCAPKIGVPSQ
                                       * :.****:* ::***:  .    *: * ::* :    ..::*    

Mflv_0276|M.gilvum_PYR-GCK          NAGNNP-------SGVVLTGFVDRVGDPVPLIAEDGSAHRGEQVLAAALD
Mvan_0621|M.vanbaalenii_PYR-1       IPGFSQ-------PRLVLSGFVERVGDPVPLVAADGSAHRGEQTLAQALD
MSMEG_0692|M.smegmatis_MC2_155      LGG----------DGLALTGFVERTGDPVPIVAADGSQHRGELALAEALD
TH_4466|M.thermoresistible__bu      GAGSVDGPAPGLGGGMVLSGFVERIGDPVPLVAADGTAHRGERVLVEALD
MMAR_0617|M.marinum_M               NPSLAG-------AGLVLRGFVERVGDQSPLIAADGTKYLGEALAVQALS
MUL_0582|M.ulcerans_Agy99           NPGLAG-------AGLVLRGFVERVGDQSPLIAADGTKYLGEALAVQALS
MAV_4816|M.avium_104                NPNLTE-------PGLVLRGFVERVGDRAPLVAADGTKYLGAALTVEAVE
MAB_4291|M.abscessus_ATCC_1997      -------------PGLTLTGFVGRVGDPVGIVAADGSVHRAEWALTEAMR
Mb0320|M.bovis_AF2122/97            NPNLIE-------PGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALD
Rv0312|M.tuberculosis_H37Rv         NPNLIE-------PGALMSGFVERIGDAVALVSPDGSVHDPDLLLVEALD
                                                     : *** * **   ::: **: :      . *: 

Mflv_0276|M.gilvum_PYR-GCK          AMAR----LVDGGSP---VAIAVPSHWGPGTVGALRGALRTVPSLSPGGV
Mvan_0621|M.vanbaalenii_PYR-1       AMAG----LVDGGAP---VAIAVPAHWGPGTVGALRGALRAAPRLSPNGI
MSMEG_0692|M.smegmatis_MC2_155      AMAR----EVGGGAP---VAIATPAYWGPAALGALRGALRNKPAFAPDGI
TH_4466|M.thermoresistible__bu      AMAR----QVGYGAP---IAVAIPAHWGPGTVGALRGALRDKPSLCPDGL
MMAR_0617|M.marinum_M               ALAR----TVGYGSP---VTIAAPAYWSGAQLGALRGALLTEPALAPNGV
MUL_0582|M.ulcerans_Agy99           ALAR----TVGYGSP---VTIAAPAYWSGAQLGALRGALLTEPALAPNGV
MAV_4816|M.avium_104                AMAR----AVGYGAP---ITIAVPAYWSDDQFAALREEFFAQSDLAREGV
MAB_4291|M.abscessus_ATCC_1997      VLIADAVSSANFTAPPV-LSASIPAHWSPQTVSTLRDAIDRVPAFAPGGR
Mb0320|M.bovis_AF2122/97            AMVL----TAGADASSSEIAIAVPAHWKPGAVHALRNGLRTHVGFVRSGM
Rv0312|M.tuberculosis_H37Rv         AMVL----TAGADASSSEIAIAVPAHWKPGAVHALRNGLRTHVGFVRSGM
                                    .:       ..  :.   :: : *::*    . :**  :     :   * 

Mflv_0276|M.gilvum_PYR-GCK          PATLIPDSTAALASLRVSPGLPGSGVVVLVDLGGSGSSVTLADAGAN---
Mvan_0621|M.vanbaalenii_PYR-1       PPALIPDATAALAALRVTPGLPSQGVVVLVDLGGSGSSITLADAGSG---
MSMEG_0692|M.smegmatis_MC2_155      PAALVPDSMAALAALKADPGLPADGVVVLCDFGGSGTSVTLADAAAD---
TH_4466|M.thermoresistible__bu      PPALVPDSVAALAALQAAPGLPAEGVIVLCDFGGTGTSISLANAGSN---
MMAR_0617|M.marinum_M               AAAVVSDAAAALAALRPTPGFPASGVVALCDFGAGGTSVTLAQVGAS---
MUL_0582|M.ulcerans_Agy99           AAAVVSDAAAALAALRPTPGFPASGVVALCDFGAGGTSVTLAQVGSS---
MAV_4816|M.avium_104                APMLVSDATAALAMLRGTPGFPSDGVIALCDFGAGGTTVTLMDGRAG---
MAB_4291|M.abscessus_ATCC_1997      QLKLIPDARAALEALAAGPGTPDRGVVVVCDLGGSGSSITLADAARG---
Mb0320|M.bovis_AF2122/97            APRLVSDAIAALTAVNSELGLPHGGVVGLLDFGGSATYVTLVETKSDSRT
Rv0312|M.tuberculosis_H37Rv         APRLVSDAIAALTAVNSELGLPHGSVVGLLDFGGSATYVTLVETKSDSRT
                                       ::.*: ***  :    * *  .*: : *:*. .: ::* :   .   

Mflv_0276|M.gilvum_PYR-GCK          --LVVVGQTVRYPEFSGDGIDRALLDHVLAGVSDTGQAD---TAGTAAVG
Mvan_0621|M.vanbaalenii_PYR-1       --AATIGQTVRYPDFSGEAIDQALLGHVLTGIADADTADPAGTAGTAAVG
MSMEG_0692|M.smegmatis_MC2_155      --YATLGQTVRYPEFSGDQIDQALLNHVLTGIAAANDAD---PAGTAAVG
TH_4466|M.thermoresistible__bu      --LDAIGDTVRHTEFSGDLIDQLLLDHVLAGAAADAEAD---PAATAAVG
MMAR_0617|M.marinum_M               --LQQIGPTFRYREFSGDEIDQLILSHLLTVTPGIDSTEVS--GTATSMG
MUL_0582|M.ulcerans_Agy99           --LQQIGPTFRYREFSGDEIDQLILNHILTVTPGIDSAEVS--GTATSMG
MAV_4816|M.avium_104                --FAPVGPSLRYTDFSGDAIDQLVLDHLLASDV---STAMR--GGSGRIG
MAB_4291|M.abscessus_ATCC_1997      --FQQIGQTIRFADFSGQQIDQMLLTQVLTDLNQD-------PEGTTSVG
Mb0320|M.bovis_AF2122/97            SDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDVD---PASTAAVG
Rv0312|M.tuberculosis_H37Rv         SDFQPVSATARYQDFSGSQIDQALLLRVIDQFGYGDDVD---PASTAAVG
                                         :. : *. :***. **: :* :::                :  :*

Mflv_0276|M.gilvum_PYR-GCK          PLMRLREECRAAKERLSSETATAVPVDLPGFRS-EVRVTRPELEQMIAGP
Mvan_0621|M.vanbaalenii_PYR-1       PLSRLRDECRAAKERLSGETATAVPVELPGFSS-DVRVTRPELEQLISEP
MSMEG_0692|M.smegmatis_MC2_155      SLAHLRSDCRNAKEALSADTVATISADLPGYTS-EVRVTRPELEQLISAP
TH_4466|M.thermoresistible__bu      ALARLREDCRRAKERLSADTVAVVPVALPAFQS-DVRVTRPELEQLIAGP
MMAR_0617|M.marinum_M               SVTLLLGGCRFAKEHLSAAPVATIATGAAGQPGADIRFSRNEFEQLITQP
MUL_0582|M.ulcerans_Agy99           SVTLLLGGCRFAKEHLSAAPVATIATGAAGQPGADIRFSRNEFEQLITQP
MAV_4816|M.avium_104                SQSRLLGACRRAKEQLSTA----VAVTVAGAPGQGAQLTRAEFEQLISTP
MAB_4291|M.abscessus_ATCC_1997      ALTRLRDQCRLAKERLSGDTATSVPVQLPGITT-DVRLTRAELEGHLRGP
Mb0320|M.bovis_AF2122/97            QLGQLREQCRAAKERLSTDVATELFAELAGCSS-SIEMTREQLEDLIQDP
Rv0312|M.tuberculosis_H37Rv         QLGQLREQCRAAKERLSTDVATELFAELAGCSS-SIEMTREQLEDLIQDP
                                        *   ** *** **      : .  ..      ..:* ::*  :  *

Mflv_0276|M.gilvum_PYR-GCK          LDGLLSLIDDTLTRNGVATENISAIATVGGGAAIPLVTQRLSERLRAPVV
Mvan_0621|M.vanbaalenii_PYR-1       LTGLLSAIDDVLQRNGIAAGDVSAVATVGGGAAIPLVTQRLSERLRAPVV
MSMEG_0692|M.smegmatis_MC2_155      LDGFLNAVEDTLQRNNIALSSVTAVATVGGGAAIPYVTQRLSERLRAPVV
TH_4466|M.thermoresistible__bu      LAGVLNAIDDTLQRNQIAPQRVTAVATVGGGAAIPLITQRLSERWRAPVI
MMAR_0617|M.marinum_M               LDRFIGSVEDMLQRSGVPRPSLAAVAAVGGGAAIPLIGNRLSERLQVPVF
MUL_0582|M.ulcerans_Agy99           LDRFIGSVEDMLQRSGVPRPSLAAVAAVGGGAAIPLIGNRLSERLQVPVF
MAV_4816|M.avium_104                LDRFLDWCQEALRRNGIGNSTLRGVAIVGGGASIPLLTARLSGRFGVPVH
MAB_4291|M.abscessus_ATCC_1997      LSNLINAIQDTVERNGIHPANITAVASVGGGASIPLVTQQLSERMRVPVI
Mb0320|M.bovis_AF2122/97            LTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVL
Rv0312|M.tuberculosis_H37Rv         LTGFIYAFDDMLARHNASWADLAAVVTVGGGANIPLVTQRLSFHTRRPVL
                                    *  .:   :: : *       : .:. ***** ** :  :** :   ** 

Mflv_0276|M.gilvum_PYR-GCK          TTPQALLNIGAGAALIAN------QTLDADAPTGMAPTGMAAAADVPTAM
Mvan_0621|M.vanbaalenii_PYR-1       TTPEPALNVAAGAALVAN------QSLATDAPTGMAP-----AADAPTAM
MSMEG_0692|M.smegmatis_MC2_155      TSPQPQLVAAAGAALLAD------RAVDAGAPTGLAPG--VAAADAPTGL
TH_4466|M.thermoresistible__bu      TTPQPQFNVAAGAALISA------RGXXX---------------------
MMAR_0617|M.marinum_M               TTAQPIFSAAIGAAMLGQ------DQSSAGAPTGAG-PAVDMPTNIVGAA
MUL_0582|M.ulcerans_Agy99           TTAQPIFSAAIGAAMLGQ------DQSSAGAPTGAG-PAVDMPTNIVGAA
MAV_4816|M.avium_104                STAQPGLSAALGAATLGA------QYASGAAPTAAAAAAVETPTEMVGAG
MAB_4291|M.abscessus_ATCC_1997      TAPQPQLAAARGVALLATRPDLPPQDATAMRPVEQPPGDATMMRPVPTGT
Mb0320|M.bovis_AF2122/97            TASQPGCAAAMGALLLAN------RGGERDSRTRTSIGLATAAAAGTS--
Rv0312|M.tuberculosis_H37Rv         TASQPGCAAAMGALLLAN------RGGERDSRTRTSIGLATAAAAGTS--
                                    ::.:.    . *.  :.                                 

Mflv_0276|M.gilvum_PYR-GCK          G---------PAVDAPTALGPAAPPVAGG--------ALAWSQDDDGVQD
Mvan_0621|M.vanbaalenii_PYR-1       G---------HAAWAAGAAGLAATESAGDGASSATFRALAWSQDDDAAGD
MSMEG_0692|M.smegmatis_MC2_155      GP-------TAALGAAGAAGTDGPESSTFR-------ALAWSEDDAPAGE
TH_4466|M.thermoresistible__bu      --------------------------------------------------
MMAR_0617|M.marinum_M               GTIGAMTEVSPTAWANQAGSAAASESASDNAKSATYRALAWSQDADTGNE
MUL_0582|M.ulcerans_Agy99           GTIGAMTEVSPTAWANQAGSAAASESASDNAKSATYRALAWSQDADTGNE
MAV_4816|M.avium_104                G-----LDMTQAAWAAQA--------------TDVDDALAWSQDADTSDE
MAB_4291|M.abscessus_ATCC_1997      G-----------TFAAPVAAAANEEPELAWSQDDSAPDLAPLQETGYQSG
Mb0320|M.bovis_AF2122/97            ----------VIELPAGDVMVIDHEALTDR-------ELAWSQTDFPSEA
Rv0312|M.tuberculosis_H37Rv         ----------VIELPAGDVMVIDHEALTDR-------ELAWSQTDFPSEA
                                                                                      

Mflv_0276|M.gilvum_PYR-GCK          PLPYTGADYTSPAGYGDAATGARPPVAFAPG---DDGYSDDLPPLPWYKR
Mvan_0621|M.vanbaalenii_PYR-1       PLPYTGEDYTVAGGYADPGTAARPSVDFAGQ---DDTYTDELAPLPWYKR
MSMEG_0692|M.smegmatis_MC2_155      PVPYAGPDYETQAG----ATAARPPVEFSHE---EEMYDAGPAPLPWYKR
TH_4466|M.thermoresistible__bu      --------------------------------------------------
MMAR_0617|M.marinum_M               PVPYTGPDATGEYGREP---ATDYAPRYDYP---DQDRYAEAAPLPWYKR
MUL_0582|M.ulcerans_Agy99           PVPYTGPDATGEYGREP---ATDYAPRYDYP---DQDRYAEAAPLPWYKR
MAV_4816|M.avium_104                PVPYTGRDATGEYASE--------ARRFDD---------VAAGGLPWYKR
MAB_4291|M.abscessus_ATCC_1997      YTVDLDDEYQGPTEATT----ARPELRFSHGPYADEDDYDDYPPLPWYRR
Mb0320|M.bovis_AF2122/97            PARFEGDSYNEGGPCWS---MRLNAVEPPKG---PAWRRIRVSQLLIGVS
Rv0312|M.tuberculosis_H37Rv         PARFEGDSYNEGGPCWS---MRLNAVEPPKG---PAWRRIRVSQLLIGVS
                                                                                      

Mflv_0276|M.gilvum_PYR-GCK          PPVLFGLAAA-AALLAVGGLAVTLTSSEG-STTVTETASTTAPSDTTPVE
Mvan_0621|M.vanbaalenii_PYR-1       PPVLFGVAAA-AALLAAGGLAVTLTGSQGDSGTVTETAS--VPTETPPAE
MSMEG_0692|M.smegmatis_MC2_155      PPILFGAAAV-AALLAAGGLAVTLTSTSGDSTPVTETSTTYSMGPSPEGP
TH_4466|M.thermoresistible__bu      -------------------------------------------------R
MMAR_0617|M.marinum_M               AAVVFSLAAAGLAILVAVVLGLTLGTSNN-----------KPVNTTVPAP
MUL_0582|M.ulcerans_Agy99           AAVVFSLAAAGLAILVAVVLGLTLGTSNN-----------KPVNTTVPAP
MAV_4816|M.avium_104                TALVLSVAGAGAAVLIALVLAINLLLTKS-----------TQDRPTSPPS
MAB_4291|M.abscessus_ATCC_1997      PLVWFIAAAA-VAGIAFTGMMVSLTSSESPAPATTTPSVNVVPSTGDAPA
Mb0320|M.bovis_AF2122/97            AVVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTP
Rv0312|M.tuberculosis_H37Rv         AVVAMTAIGGVALTLTAIERRPSPLPTPIVPGLAPMPPGSVVPSSRAPTP
                                                                                      

Mflv_0276|M.gilvum_PYR-GCK          LPPP-VTTVTIGPDGVATTTVSQPPPPPPSSTSSTTTTTPSSSTTTTTTT
Mvan_0621|M.vanbaalenii_PYR-1       LPPP-VTTVTVGADGIATTTVSQPPPPPPSSSTTTPTTASTTSPTTTTTT
MSMEG_0692|M.smegmatis_MC2_155      PPEP-VTTVTVGPDGQQTTTVVVPPPVTTTTTEPTSTTSPTTTTTTTTTT
TH_4466|M.thermoresistible__bu      LSRP-ASTPRSGSEIRASRSAR---------VTRTTDRWPGSSTATSATV
MMAR_0617|M.marinum_M               LPEP-ITTTILGPNSSPTVTVITPTPPSTTTTSPSATTTTTQPTTTTTTT
MUL_0582|M.ulcerans_Agy99           SPEP-ITTTILGPNSSPTVTVITPTPPSTTTTSPSATTTTTQPTTTTTTT
MAV_4816|M.avium_104                TPAPPQTVTITGPNDSTTVTVVPAPPPPSSEAPPPPATTTTAPPEPSTTT
MAB_4291|M.abscessus_ATCC_1997      EPPP--SPEPPPPPQTHTVTQSVQPPPPSPEPPPPPPPTTTTTTTPPTTT
Mb0320|M.bovis_AF2122/97            PPPP-STVAPLPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTT
Rv0312|M.tuberculosis_H37Rv         PPPP-STVAPLPSAAPAPTTVAPAPPPPTQVVTTTTAPPVTTTPRPSPTT
                                     . *  :     .    . :              ..      .. ...*.

Mflv_0276|M.gilvum_PYR-GCK          TT---------TTTTTTTNTAPTTTTTRTTTAPPTTTPPPTTTQAPPPPT
Mvan_0621|M.vanbaalenii_PYR-1       TT---------TTTTTTT-----TTTTRTTTTQPTTTAPPTTTQPPPPTT
MSMEG_0692|M.smegmatis_MC2_155      TT---------TTTTTTTPTTTRTTTTQPTTTAPTTTAPPTTTQAPITTT
TH_4466|M.thermoresistible__bu      SA---------DNRSLARRQCSRSLLNAPTAAVPAGSVPPDWATLSSTND
MMAR_0617|M.marinum_M               TTPTTTTTTTTTTTPPTTTTTTQPTTTRTTTTQATTTAPP-TTTQQPSTT
MUL_0582|M.ulcerans_Agy99           TT--------TTTTPP-TTTTTQPTTTRTTTTQPTTTAPP-TTTQQPSTT
MAV_4816|M.avium_104                TT----------TTPP-------PSSTTTTSAAPTTTAQPSTTSAAPTTT
MAB_4291|M.abscessus_ATCC_1997      TT----------TTTTTTTTTTTTTTPTTTTTQPTTTTTQPTSTSRPAIT
Mb0320|M.bovis_AF2122/97            TTTTAP-----PSTTTTTELPVTTTSTIPTIPTTTTTVKMTTEWLHVPFL
Rv0312|M.tuberculosis_H37Rv         TTTTAP-----PSTTTTTEPPVTTTSTIPTIPTTTTTVKMTTEWLHVPFL
                                    ::          . .        .    .* . .: :          .  

Mflv_0276|M.gilvum_PYR-GCK          TEEPPP-TVDPPDPIVTT-VIPDGGA-
Mvan_0621|M.vanbaalenii_PYR-1       TAAPPPTTVDPPDPVTTTVIIPEDGA-
MSMEG_0692|M.smegmatis_MC2_155      TVEIPD-VPDDPD------VPDDGGA-
TH_4466|M.thermoresistible__bu      SRA------------------------
MMAR_0617|M.marinum_M               TAAPITPTTEAPGA-------------
MUL_0582|M.ulcerans_Agy99           TAAPITPTTEAPGA-------------
MAV_4816|M.avium_104                RVRPIPPIFQPPFGR------------
MAB_4291|M.abscessus_ATCC_1997      IPGLPPIPIGPRN--------------
Mb0320|M.bovis_AF2122/97            PVPIPVPIPQNPGAGEPQNPFGSLGSG
Rv0312|M.tuberculosis_H37Rv         PVPIPVPIPQNPGAGEPQNPFGSLGSG