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aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_0691 | dfrA | - | 100% (168) | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2785c | dfrA | 1e-63 | 70.06% (157) | dihydrofolate reductase |
| M. gilvum PYR-GCK | Mflv_4006 | - | 5e-65 | 68.35% (158) | dihydrofolate reductase |
| M. tuberculosis H37Rv | Rv2763c | dfrA | 1e-63 | 70.06% (157) | dihydrofolate reductase DFRA (DHFR) (tetrahydrofolate |
| M. leprae Br4923 | MLBr_01518 | folA | 1e-57 | 62.11% (161) | dihydrofolate reductase |
| M. abscessus ATCC 19977 | MAB_3090c | - | 5e-49 | 57.50% (160) | dihydrofolate reductase DfrA |
| M. marinum M | MMAR_1957 | dfrA | 5e-62 | 67.90% (162) | dihydrofolate reductase DfrA |
| M. avium 104 | MAV_3651 | folA | 4e-63 | 70.19% (161) | dihydrofolate reductase |
| M. smegmatis MC2 155 | MSMEG_2671 | folA | 6e-58 | 66.45% (155) | dihydrofolate reductase |
| M. ulcerans Agy99 | MUL_2179 | dfrA | 3e-62 | 67.90% (162) | dihydrofolate reductase DfrA |
| M. vanbaalenii PYR-1 | Mvan_2381 | - | 3e-61 | 64.56% (158) | dihydrofolate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4006|M.gilvum_PYR-GCK ------MTELNLIWAQSSSGVIGRDGGIPWHVPEDMARFKELTMGHTVIM
Mvan_2381|M.vanbaalenii_PYR-1 ----MTLSELNMVWAQSSSGVIGRGDAIPWHVPEDMARFKELTMGHTVIM
MSMEG_2671|M.smegmatis_MC2_155 ---------MRLIWAQSTSGIIGRDNSIPWRLPEDLARFKEMTMGHPVVM
TH_0691|M.thermoresistible__bu MSAGESPREVGLIWAQSTSGVIGRDGGLPWQLPEDLARFKEITMGHTVVM
Mb2785c|M.bovis_AF2122/97 --------MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVM
Rv2763c|M.tuberculosis_H37Rv --------MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVM
MLBr_01518|M.leprae_Br4923 ------MTVVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVM
MMAR_1957|M.marinum_M ------MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVM
MUL_2179|M.ulcerans_Agy99 ------MTSVGLIWAQSTSGVIGRDGGIPWRLPEDLAHFKRLTMGHTVVM
MAV_3651|M.avium_104 ---------MGLVWAQSTSGVIGRGGDIPWNVPEDLTRFKEVTMGHTVIM
MAB_3090c|M.abscessus_ATCC_199 -----MTGTIGLIWAQTRAGVIGADGAIPWRLPEDQARFKRITMGHTVIM
: ::***: :*:** .. :**.:*** ::*:.:****.::*
Mflv_4006|M.gilvum_PYR-GCK GRQTWESLPEKFRPLPGRRNVVLTRQADYVAEGAEVVTALEDAPL----D
Mvan_2381|M.vanbaalenii_PYR-1 GRLTWESLPAKFRPLPGRRNVVVTRQAGYQADGAEVVTSFEDAPL----D
MSMEG_2671|M.smegmatis_MC2_155 GRLTWESLPASVRPLPGRRNIVVTRDADYRAEGAEVVTDLPDEP------
TH_0691|M.thermoresistible__bu GRRTWESLPAAVRPLPGRKNVVLSRRSDYPAEGAQVVHTLDDALG----D
Mb2785c|M.bovis_AF2122/97 GRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALT----S
Rv2763c|M.tuberculosis_H37Rv GRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALT----S
MLBr_01518|M.leprae_Br4923 GRRTWDSLPVGVRPLPGRRNIVLSRQIDFMAEGAEVFGSLEETISNLETE
MMAR_1957|M.marinum_M GRRTWDSLPAAHRPLPGRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPD
MUL_2179|M.ulcerans_Agy99 GRRTWDSLPAAHRPLPGRRNVVVTRQTGLVAHGAQVVGSLEQALCPAEPD
MAV_3651|M.avium_104 GRRTWESLPAKVRPLPGRRNVVVSRRPDFVAEGARVAGSLEAALAYAGSD
MAB_3090c|M.abscessus_ATCC_199 GRKTWESLPGSVRPLPGRPNIVLTRDALFEPDGALAVGCADAALAAS--D
** **:*** ****** *:*::* . ** .
Mflv_4006|M.gilvum_PYR-GCK -DAWVIGGSQVYGLALPLATRCEITEVDLDLHRQDEDALAPLLDEAWVGT
Mvan_2381|M.vanbaalenii_PYR-1 -DAWVIGGSQIYGLALPLATRCEITEVDIDLRREDDDALAPVLDEAWVGT
MSMEG_2671|M.smegmatis_MC2_155 -DAWVIGGAQIYAMALARADRCEVTEVDIALTPLDGDARAPVLDDSWVAT
TH_0691|M.thermoresistible__bu GETWVIGGAEIFGLALEVATRCEVTEIEIDLRRREGDAMAPVLDESWVGT
Mb2785c|M.bovis_AF2122/97 PETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGE
Rv2763c|M.tuberculosis_H37Rv PETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGE
MLBr_01518|M.leprae_Br4923 PEMWVIGGEQIYRLALPLATRCGVTEVDTYLLHEDDDVLAPVLDDTWVGV
MMAR_1957|M.marinum_M AETWVIGGAQIYALALPLANRCEVTEVDVDLPPEDEDALAPVLDQTWAGT
MUL_2179|M.ulcerans_Agy99 AETWVIGGAQIYALALPLANRCEVTEVDVDLPPEDEDALAPVLDQTWAGT
MAV_3651|M.avium_104 PAPWVIGGAQIYLLALPHATRCEVTEIEIDLRRDDDDALAPALDDSWVGE
MAB_3090c|M.abscessus_ATCC_199 EAPWVIGGGEIYRLFLPLAQRCEVTVVEADVP---GDALAPELGEGWVVE
***** ::: : * * ** :* :: : *. ** *.: *
Mflv_4006|M.gilvum_PYR-GCK EGEWRDSASGLRYRFYSYVRK--------------
Mvan_2381|M.vanbaalenii_PYR-1 EGDWRDSSSGLRYRFYSFVRK--------------
MSMEG_2671|M.smegmatis_MC2_155 TGEWQTSTSGLRFRFCSYRR---------------
TH_0691|M.thermoresistible__bu VGEWRTSRSGLRYRYYHYTRV--------------
Mb2785c|M.bovis_AF2122/97 TGEWRFSRSGLRYRLYSYHRS--------------
Rv2763c|M.tuberculosis_H37Rv TGEWRFSRSGLRYRLYSYHRS--------------
MLBr_01518|M.leprae_Br4923 TGEWLVSCSGLRYRLHSYHRS--------------
MMAR_1957|M.marinum_M SGEWLVSRSGLRYRMHSYRRL--------------
MUL_2179|M.ulcerans_Agy99 SGEWLVSRSGLRYRMHSYRRL--------------
MAV_3651|M.avium_104 TGEWLASRSGLRYRFHSYRRDPRSSVRGCSPSRPS
MAB_3090c|M.abscessus_ATCC_199 ENDWQTSESGLRYQFLSYRKVDG------------
.:* * ****:: : :