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PSLPTTPAETAMTTLTGKTRWTIAILAVVAALMAALVAQLHDYSASSTISQRPAPREHRDGDTPEALAWS RQRANLPPCPAAGNGPGAAALRGVVVVCAGDGSAVDVARALAGRRVVINLWAHWCAPCMTELPVMAEYQR RVGPAVLVVTVHQGQNEAAALSRLADLGVRLPTLQDDRRRVAAALRVANVMPATVVLRPDGSVAQTLPRA FGSADEIVAAVGNDAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3673c | - | - | 100% (227) | POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) |
| M. tuberculosis H37Rv | Rv0526 | - | 7e-06 | 29.36% (109) | thioredoxin protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3697c | - | 1e-128 | 100.00% (227) | membrane-anchored thioredoxin-like protein |
| M. gilvum PYR-GCK | Mflv_1374 | - | 3e-63 | 58.82% (204) | alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal |
| M. leprae Br4923 | MLBr_02300 | - | 2e-81 | 71.16% (215) | hypothetical protein MLBr_02300 |
| M. abscessus ATCC 19977 | MAB_0419 | - | 5e-59 | 55.77% (208) | hypothetical protein MAB_0419 |
| M. marinum M | MMAR_5161 | - | 9e-82 | 71.03% (214) | membrane-anchored thioredoxin-like protein |
| M. avium 104 | MAV_0456 | - | 1e-83 | 72.22% (216) | hypothetical protein MAV_0456 |
| M. smegmatis MC2 155 | MSMEG_6186 | - | 4e-70 | 66.67% (204) | hypothetical protein MSMEG_6186 |
| M. thermoresistible (build 8) | TH_0960 | - | 4e-25 | 69.14% (81) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_4247 | - | 1e-76 | 71.14% (201) | membrane-anchored thioredoxin-like protein |
| M. vanbaalenii PYR-1 | Mvan_5432 | - | 2e-64 | 63.73% (204) | redoxin domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1374|M.gilvum_PYR-GCK ------------------------MALVILVALGVAFWSELDAQDPASPA
Mvan_5432|M.vanbaalenii_PYR-1 ------------------------MALVIVVALGAALWAELDADE-SQPR
MSMEG_6186|M.smegmatis_MC2_155 ---------------MSVSTRWTVAVLVVLLALGTAFWLELRDDG-AAPG
Rv3673c|M.tuberculosis_H37Rv MPSLPTTPAETAMTTLTGKTRWTIAILAVVAALMAALVAQLHDYS-ASST
Mb3697c|M.bovis_AF2122/97 MPSLPTTPAETAMTTLTGKTRWTIAILAVVAALMAALVAQLHDYS-ASST
MLBr_02300|M.leprae_Br4923 ------------MKTLTPKTCGTIVVLAVVVALVAALVGQLRDNA-RTIE
MMAR_5161|M.marinum_M ---------MPELTRLTPGARWTIAVLAVVVALIIALAAQLREGS-GPAG
MUL_4247|M.ulcerans_Agy99 -------------------------MLAVVVALIIALAAQLREGS-GSAG
MAV_0456|M.avium_104 --------MPIPRPTLTRKVRWHIAILAVVVALIVALLAQLRDDA-ATPG
TH_0960|M.thermoresistible__bu --------------------------------------------------
MAB_0419|M.abscessus_ATCC_1997 ------------MARLNTGARWTIAGVVLVAALIAVMLSQQHDQQRRGPQ
Mflv_1374|M.gilvum_PYR-GCK GNDARDTVSARDKRDADTPEALAGLRAAAGLEPCPAPGE-GQGPAPLRGI
Mvan_5432|M.vanbaalenii_PYR-1 --TQRDAISARDRRDADTPEALAGLRARAALEPCPTGGDAGPGPETLRGI
MSMEG_6186|M.smegmatis_MC2_155 --AEAPSATARDHRDADTPEALAEPRARADLPPCPGPGN-GQGPEALRGM
Rv3673c|M.tuberculosis_H37Rv ISQR---PAPREHRDGDTPEALAWSRQRANLPPCPAAGN-GPGAAALRGV
Mb3697c|M.bovis_AF2122/97 ISQR---PAPREHRDGDTPEALAWSRQRANLPPCPAAGN-GPGAAALRGV
MLBr_02300|M.leprae_Br4923 MTQA---TIEREHRDADTPAALAGPREHANLPPCPDAGS-GPGPAVLRGV
MMAR_5161|M.marinum_M HTGA---PVAREHRDADTPAALAGPRRRANLPPCPAGGA-GPGPARLQGV
MUL_4247|M.ulcerans_Agy99 HTGA---PVAREHRDADTPAALAGPRRRSNLPPCPAGGA-GPGPARLQGV
MAV_0456|M.avium_104 PPATGRVVADREHRDADTPAALAGPRQRADLPPCPAAGT-GPGPAALRGV
TH_0960|M.thermoresistible__bu --------------------------------------------------
MAB_0419|M.abscessus_ATCC_1997 GQQQ---VAARERRDAETPEALAELRRQAQLPSCPAANP-DPGTPALAGI
Mflv_1374|M.gilvum_PYR-GCK VLECVGDGAPTDIAAAVAGRPVVLNLWAYWCGPCADELPAMAEYQRRVGP
Mvan_5432|M.vanbaalenii_PYR-1 ELECVGDGSRVDVAEAVAGRPVVLNLWAYWCGPCADELPAMAEYQRRVGS
MSMEG_6186|M.smegmatis_MC2_155 TLECAGDGDPVDVAAALAGRPVVLNLWAYWCGPCADELPAMAEYQRRN-P
Rv3673c|M.tuberculosis_H37Rv VVVCAGDGSAVDVARALAGRRVVINLWAHWCAPCMTELPVMAEYQRRVGP
Mb3697c|M.bovis_AF2122/97 VVVCAGDGSAVDVARALAGRRVVINLWAHWCAPCMTELPVMAEYQRRVGP
MLBr_02300|M.leprae_Br4923 VLECASDGFAVDVARALAGRRVVLNLWASWCASCLGELPAMVEYQRRVGS
MMAR_5161|M.marinum_M VVECAANGAPVDVASAVAGRRVLLNLWAYWCAECTAELPALAEYQRRVGS
MUL_4247|M.ulcerans_Agy99 VVECAANGAPVDVASAVAGRRVLLNLWAYWCAECTAELPALAEYQRRVGS
MAV_0456|M.avium_104 TAECAADGSVVDAGRAVAGRRVVLNFWAYWCAPCAAELPAMAEYQRRAGA
TH_0960|M.thermoresistible__bu --------------------------------------------------
MAB_0419|M.abscessus_ATCC_1997 TLECS--GVRVPVGPVLAGRQVVLNLWAYWCGPCADELPAMAELQRRAGD
Mflv_1374|M.gilvum_PYR-GCK EVLVLTVHQDENESAALIRLAELGVHLPTVQDGRRSIAAALQVPNVMPAT
Mvan_5432|M.vanbaalenii_PYR-1 AVTVLTVHQDENESAALLRLTELGVHLPTLQDGRRTIAAALQVPNVMPAT
MSMEG_6186|M.smegmatis_MC2_155 DVLVLTVHQDENETAALLRLAELGVRLPTLQDGRRLVAAALKVPNVMPAT
Rv3673c|M.tuberculosis_H37Rv AVLVVTVHQGQNEAAALSRLADLGVRLPTLQDDRRRVAAALRVANVMPAT
Mb3697c|M.bovis_AF2122/97 AVLVVTVHQGQNEAAALSRLADLGVRLPTLQDDRRRVAAALRVANVMPAT
MLBr_02300|M.leprae_Br4923 DVMVVTVHQDENEMAALLRLAQLGVRLPTLQDGRRRVAAAFGVANVIPTT
MMAR_5161|M.marinum_M EVTVLTVHQDENEAAALVELADLGVRLPTLQDGRRKVAAALGVANVMPAT
MUL_4247|M.ulcerans_Agy99 EVTVLTVHQDENEAAALVELADLGVRLPTLQDGRRKVAAALGVANVMPAT
MAV_0456|M.avium_104 EVTVLTVHQDENETAALLRLAELGVRLPTLQDGRRRVAAALRVVNVMPAT
TH_0960|M.thermoresistible__bu -VTVLTVHQDPNEAAGLALLTELGVRLPTLQDGERRIAAALRVPNVMPAT
MAB_0419|M.abscessus_ATCC_1997 KLTVITVHQDENEAAGLNRLAELHVRLPMIQDGARRIAAALKSPNVMPTT
: *:****. ** *.* *::* *:** :**. * :***: **:*:*
Mflv_1374|M.gilvum_PYR-GCK VVLRADGSVAEILPRSFATADDIAAAVDPKIGVA-
Mvan_5432|M.vanbaalenii_PYR-1 VVLRADGSVAEILPRSFATADEIAAAVDPKIGAA-
MSMEG_6186|M.smegmatis_MC2_155 VVLRPDGSVAEILPRSFVDADEIAAAVDELIRSSR
Rv3673c|M.tuberculosis_H37Rv VVLRPDGSVAQTLPRAFGSADEIVAAVGNDAG---
Mb3697c|M.bovis_AF2122/97 VVLRPDGSVAQTLPRAFGSADEIVAAVGNDAG---
MLBr_02300|M.leprae_Br4923 VVLRPDGSVAQTLPRALVSVDQIAAAVGNDTG---
MMAR_5161|M.marinum_M VLLRPDGSVAQTLPRAFGSADEIAAAVGNPA----
MUL_4247|M.ulcerans_Agy99 VLLRPDGSVAQTLPRAFGSADEIAAAVENPA----
MAV_0456|M.avium_104 VVLRPDGSVAQTLPRAFSTADEIAAAIGNDRG---
TH_0960|M.thermoresistible__bu VVLRADGTVGEVLPRAFTTADEIAAAVERELGESR
MAB_0419|M.abscessus_ATCC_1997 ILIRADGSVAQVLPRSFTSADEIGAEVEQALGMRF
:::*.**:*.: ***:: .*:* * :