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TEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDAIRKSL DNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLSIFG PVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRF SADRAADWYSLGLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALAS SVTCGPAHGPLPADLGSHPSH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3397c | phyA | - | 100% (302) | PROBABLE PHYTOENE SYNTHASE PHYA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3430c | phyA | 1e-171 | 100.00% (302) | phytoene synthase |
| M. gilvum PYR-GCK | Mflv_1846 | - | 1e-24 | 31.60% (288) | squalene/phytoene synthase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4807 | crtB | 6e-28 | 31.45% (283) | phytoene synthase, CrtB |
| M. avium 104 | MAV_3886 | - | 7e-27 | 30.56% (288) | phytoene synthase |
| M. smegmatis MC2 155 | MSMEG_2346 | - | 1e-24 | 30.74% (283) | phytoene synthase |
| M. thermoresistible (build 8) | TH_1482 | - | 3e-22 | 28.03% (289) | phytoene synthase |
| M. ulcerans Agy99 | MUL_0375 | crtB | 4e-29 | 31.80% (283) | phytoene synthase, CrtB |
| M. vanbaalenii PYR-1 | Mvan_1579 | - | 1e-22 | 30.82% (292) | squalene/phytoene synthase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1846|M.gilvum_PYR-GCK MIGSELDAAGVRDKDLRQAYRECRRLNAQHGKTFFLATRLLTPAQRPAVH
Mvan_1579|M.vanbaalenii_PYR-1 MIKIELDAAGVRDPELRDAYRQCRTINAQHGKTFYLATRLLAPRQRPAVH
TH_1482|M.thermoresistible__bu VIGSELDAAGVSDPALREAYRRCRMLNAAHGRTFFLATRLLAPHQRPAVH
MMAR_4807|M.marinum_M MIRSELDAAGIGDPRLREAYQQSRRINAASGRTFFLATRLLAPDQRPPVH
MUL_0375|M.ulcerans_Agy99 MIRSELDAAGIGDPRLREAYQQSRRINAASGRTFFLATRLLAPDQRPPVH
MSMEG_2346|M.smegmatis_MC2_155 MIRNEFAAAGIDDPMLREAYRRCREINAAHGRTFFLATRLLAPDQRPAVH
MAV_3886|M.avium_104 MMRSEWAAAGIEDPLLREGYRRCRELNAAHGRTFFLATRLLAPDQRPPVH
Rv3397c|M.tuberculosis_H37Rv ------------MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALS
Mb3430c|M.bovis_AF2122/97 ------------MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALS
:.:.*: . :. .:.*: . ***. :*..:
Mflv_1846|M.gilvum_PYR-GCK ALYGFARRADDVLDSFDD-RSVAARADELQNLATALFTRLVEKQHSGNDP
Mvan_1579|M.vanbaalenii_PYR-1 ALYGFARFADDILDDLADTATVEQRAERLQQLSTRLFHCLVDKESCEGDP
TH_1482|M.thermoresistible__bu ALYGFARQADDILDDFNPDRGAVERAEQLQRLATRLFDALVQGTGCGADP
MMAR_4807|M.marinum_M ALYGFARYADDILDSFDPRLDTDTRAQRLQQLAQQFFSGADHP----DNP
MUL_0375|M.ulcerans_Agy99 ALYGFARYADDILDSFDPRLDPDTRAQRLQQLAQQFFSGADHP----DNP
MSMEG_2346|M.smegmatis_MC2_155 ALYGFARYADDILDEFDPTLDTAARARQLQLLADQFFARAEHP----GDP
MAV_3886|M.avium_104 ALYGFARYADDILDDLDPRVAPAVRARRLQRLSERLFSGGAHT----DDP
Rv3397c|M.tuberculosis_H37Rv AVYALGRRIDDVAD---GELAPETKITELDAIRKSLDNIDDSS-----DP
Mb3430c|M.bovis_AF2122/97 AVYALGRRIDDVAD---GELAPETKITELDAIRKSLDNIDDSS-----DP
*:*.:.* **: * : .*: : : :*
Mflv_1846|M.gilvum_PYR-GCK VLDAVEDTARHYRIDWQLFDDFLASMRMDLTITDYPDRAALDRYIYGSAE
Mvan_1579|M.vanbaalenii_PYR-1 ILTAVVHTARTYDIGWDLFDDFLASMRMDLTVTDYPDRQALERYMYGSAE
TH_1482|M.thermoresistible__bu ALAAVVHTARRYDISWNLFDDFLASMRMDLTVTDYPDRPALEHYMHGSAE
MMAR_4807|M.marinum_M VLAAVSHTARRYGIGADLFEDFLESMRMDLTITDYPDRDALNTYMRGSAE
MUL_0375|M.ulcerans_Agy99 VLAAVSHTARRYGIGADLFEDFLESMRMDLSITDYPDRDALNTYMRGSAE
MSMEG_2346|M.smegmatis_MC2_155 VLTAVGHTVARYGIADELFEDFLRSMRMDLSVTDYADRAALEEYMRGSAE
MAV_3886|M.avium_104 LVAAVTHTARRYRISSQLFADFLASMRMDLTVTDYPDREALNRYMRGSAE
Rv3397c|M.tuberculosis_H37Rv VLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAG
Mb3430c|M.bovis_AF2122/97 VLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAG
: *: .:. : : :* ::: . **:: *. * * * .*
Mflv_1846|M.gilvum_PYR-GCK VIGLQMLPVLGTVVPREEAAPYAAALGKAFQLTNFLRDIDEDLTRGRVYL
Mvan_1579|M.vanbaalenii_PYR-1 VIGLQMLPVLGTVGPREEAAPYAAALGKAFQLTNFLRDVDEDLTRGRVYL
TH_1482|M.thermoresistible__bu VIGLQMLPVLGTVVPREEAAPYAAALGKAFQLTNFLRDVDEDLQRGRVYL
MMAR_4807|M.marinum_M AIGLQLLPILGTVVPAREAMPYAAALGRAFQLTNFIRDVDEDLARNRIYL
MUL_0375|M.ulcerans_Agy99 AIGLQLLPILGTVVPAREAMPYAAALGRAFQLTNFIRDVDEDLARNRIYL
MSMEG_2346|M.smegmatis_MC2_155 AIGLQLLPILGTVTAPEEAAPHAAALGRAFQLTNFLRDVDEDLLRDRVYL
MAV_3886|M.avium_104 AIGLQVLPILGTVTPVDEAAPYAAALGRAFQLTNFLRDVDEDLARGRVYL
Rv3397c|M.tuberculosis_H37Rv TIGKLCLSIFGPVS--TATSRYAEQLGIALQQTNILRDVREDFLNGRIYL
Mb3430c|M.bovis_AF2122/97 TIGKLCLSIFGPVS--TATSRYAEQLGIALQQTNILRDVREDFLNGRIYL
.** *.::*.* : :* ** *:* **::**: **: ..*:**
Mflv_1846|M.gilvum_PYR-GCK PADELAAHGVDREVLTWCQRNRRTDRRLRAALVEQHALTRRIYVQAERGI
Mvan_1579|M.vanbaalenii_PYR-1 PADELAAHGVDRELLTWCQANGRIEPRVRAALAEQHAITRQVYQQARPGI
TH_1482|M.thermoresistible__bu PADELAAHDVDRDVLMWCHTRHRTDPRVRRALAEQHAVTRRVYDYARTGI
MMAR_4807|M.marinum_M PADELAAYGVDRDVLMWCHHNQRSDGRVREALAAQHEITRETYRFAAAGI
MUL_0375|M.ulcerans_Agy99 PADELAAYGVDRDVLMWCHHNQRSDGRVREALAAQHEITRETYRFAAAGI
MSMEG_2346|M.smegmatis_MC2_155 PADELAVHGVDRDLLMWCHHNQHTDSRVRKALQAQHEIARRTYRYAAEGI
MAV_3886|M.avium_104 PADELAADGVDRELLMWCHEHRRTDPRVRRALIAQHHIARQTYRFATAGI
Rv3397c|M.tuberculosis_H37Rv PRDELDRLGVRLRLDDTGALDD-PDGRLAALLRFSADRAADWYSLGLRLI
Mb3430c|M.bovis_AF2122/97 PRDELDRLGVRLRLDDTGALDD-PDGRLAALLRFSADRAADWYSLGLRLI
* *** .* : : *: * . : * . *
Mflv_1846|M.gilvum_PYR-GCK AMLHPHSRPCVGAALTLYSEILDRIEEIDFAVFAQRATVSTARRLQVASA
Mvan_1579|M.vanbaalenii_PYR-1 AALAPPSRPCVAAALTLYSDILSRIEAIDFEIFGRRATVGKPRRLVVAAA
TH_1482|M.thermoresistible__bu AMLAPGSRPCISAALTLYSEILDRIESIDYAIFSQRASVGTARRLRVACG
MMAR_4807|M.marinum_M QLLAPRSRPCVATALTLYSEILDRIEGDDFAVFGRRATVGTARRLRVAGA
MUL_0375|M.ulcerans_Agy99 QLLAPRSRPCVATALTLYSEILDRIEGDDFAVFGRRATVGTARRLRVAGA
MSMEG_2346|M.smegmatis_MC2_155 AMLAPRSRPCVATAMQLYSEILDCIEESDFAIFRRRATVGTRRRIQVAGA
MAV_3886|M.avium_104 AVLQHRSRPCVAAAAALYSEILDCIEKSDFAVFGHRATVGTARRLRVGAV
Rv3397c|M.tuberculosis_H37Rv PHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAA
Mb3430c|M.bovis_AF2122/97 PHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAA
* * .* .: :* * *. :: :* ::. :: *.
Mflv_1846|M.gilvum_PYR-GCK GLARAARAR-FRHRGA---------
Mvan_1579|M.vanbaalenii_PYR-1 GIGKAWGQR-MRSRGA---------
TH_1482|M.thermoresistible__bu GLIRAWRSRGAEPAGGR--------
MMAR_4807|M.marinum_M GLIRAWRARTSDAIPDRSEYGAA--
MUL_0375|M.ulcerans_Agy99 GLIRAWRARTSDAIPDRSEYGAA--
MSMEG_2346|M.smegmatis_MC2_155 GLIHAWRARSHAAAVP----GAA--
MAV_3886|M.avium_104 GLIRSWRARNSGRGIRS---GAA--
Rv3397c|M.tuberculosis_H37Rv ALASSVTCGPAHGPLPADLGSHPSH
Mb3430c|M.bovis_AF2122/97 ALASSVTCGPAHGPLPADLGSHPSH
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