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TDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHG RGWAATARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAG ILAEVAQPFVVLGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAAD YRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3279c | birA | - | 100% (266) | biotin--protein ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3307c | birA | 1e-148 | 99.62% (266) | biotin--protein ligase |
| M. gilvum PYR-GCK | Mflv_4741 | - | 1e-65 | 51.33% (263) | biotin--acetyl-CoA-carboxylase ligase |
| M. leprae Br4923 | MLBr_00732 | birA | 1e-104 | 71.22% (271) | biotin apo-protein ligase |
| M. abscessus ATCC 19977 | MAB_3626c | - | 3e-69 | 55.20% (250) | biotin--acetyl-CoA-carboxylase ligase (BirA bifunctional |
| M. marinum M | MMAR_1257 | birA | 1e-101 | 69.78% (278) | bifunctional protein BirA |
| M. avium 104 | MAV_4248 | - | 3e-97 | 68.94% (264) | biotin- |
| M. smegmatis MC2 155 | MSMEG_1822 | - | 4e-66 | 52.24% (268) | biotin- |
| M. thermoresistible (build 8) | TH_0886 | - | 4e-39 | 49.71% (175) | biotin- |
| M. ulcerans Agy99 | MUL_2631 | birA | 1e-101 | 69.78% (278) | bifunctional protein BirA |
| M. vanbaalenii PYR-1 | Mvan_1722 | - | 4e-71 | 56.43% (241) | biotin--acetyl-CoA-carboxylase ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4741|M.gilvum_PYR-GCK --MPTPERPALNVDVLRSAITGTE--WHRVDVVDETGSTNADLIARADRG
Mvan_1722|M.vanbaalenii_PYR-1 --MPS----QLNIDELRAAVSDTE--WRRVDVVEETGSTNADLIARAAAG
Rv3279c|M.tuberculosis_H37Rv MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASG
Mb3307c|M.bovis_AF2122/97 MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASG
MMAR_1257|M.marinum_M MTDRDQLRLPLDASKLRSEAIDSG--WRQLDVVDETGSTNADLLARAAAG
MUL_2631|M.ulcerans_Agy99 MTDRDQLRLPLDASKLRSEAIDSG--WRQLDVVDETGSTNADLLARAAAG
MLBr_00732|M.leprae_Br4923 -MGSDLLKPPLDPAALRAELIGTGLRWRQLDVVTQTGSTNADLLARAASG
MAV_4248|M.avium_104 ----------MDAAALRAELIGTGLGWRRLDVVEQTGSTNADLLARAAAG
MAB_3626c|M.abscessus_ATCC_199 -MTSDRL----------TLTDSPGGHWRRIDVVEETGSTNADLVTRAAAG
TH_0886|M.thermoresistible__bu --------------------------------VPTTG-------------
MSMEG_1822|M.smegmatis_MC2_155 -MNSDTERPALDADAIRSAVVRPRGSWRSFDVVAETGSTNADLLARARSG
* **
Mflv_4741|M.gilvum_PYR-GCK EDIAGAVLLAEHQTAGRGRHGRTWSAPPRSQISMSFGVDTTGVPPAGWGW
Mvan_1722|M.vanbaalenii_PYR-1 EDIAGAVLLAEHQTAGRGRHGRSWSAPPRSQISMSVGVDATGVPAERWGW
Rv3279c|M.tuberculosis_H37Rv ADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGW
Mb3307c|M.bovis_AF2122/97 ADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGW
MMAR_1257|M.marinum_M ADIEGAVLIAEHQTAGRGRLGRGWSATARAQITMSVGVRVDGVPTATWGW
MUL_2631|M.ulcerans_Agy99 ADIEGAVLIAEHQTAGRGRLGRGWSATARAQITMSVGVRVDGVPTATWGW
MLBr_00732|M.leprae_Br4923 IDIDGAVLIAEHQTAGRGRHGRGWSASPRTQITMSIGVSIADVPVATWAW
MAV_4248|M.avium_104 DDVAGAVLIAEHQTAGRGRHGRGWSATPRAQVTMSVGVSVVDVPAAGWGW
MAB_3626c|M.abscessus_ATCC_199 EDIDGVVLLAEHQTAGRGRHGRSWGAPAHTQLSMSVGIGVGEVPPDRWGL
TH_0886|M.thermoresistible__bu ------------------------------------------VRPDRWGW
MSMEG_1822|M.smegmatis_MC2_155 TDINGAVLAAEHQTAGRGRNGRQWTTPPRSQIAVSVGIDTTGVPSTAWGL
* *.
Mflv_4741|M.gilvum_PYR-GCK LPLLTGLAVAHTLR---ESYGVNAGVKWPNDVMVGP----RKLAGILAEV
Mvan_1722|M.vanbaalenii_PYR-1 LPLLTGLAVAHVVR---EDYGVDAGVKWPNDILVGT----GKLAGILAEV
Rv3279c|M.tuberculosis_H37Rv LSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLAR--G--GKLAGILAEV
Mb3307c|M.bovis_AF2122/97 LSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLAR--G--GKLAGILAEV
MMAR_1257|M.marinum_M LSLATGLAVVDTVTPLLDGTAAQAGLKWPNDVLAGPPGSLGKLAGILAEV
MUL_2631|M.ulcerans_Agy99 LSLATGLAVVDTVTPLLDGTAAQAGLKWPNDVLAGLPGSLGKLAGILAEV
MLBr_00732|M.leprae_Br4923 LSLATGVAVLDTVAPLIDVTGVDAGLKWPNDVLAGPPGSKGKLAGILAEV
MAV_4248|M.avium_104 LPLATGVAVVDTVAPLLQPAGVAVGLKWPNDVLAGPAGSPGKLAGILAEV
MAB_3626c|M.abscessus_ATCC_199 VPLLAGVAIVDAVA---EVSGIQAGLKWPNDVLVDG----RKLCGILAEV
TH_0886|M.thermoresistible__bu LPLAAGVAVVDALA---EVAGVSAGLKWPNDVLVDG----RKIAGILAEV
MSMEG_1822|M.smegmatis_MC2_155 LPLATGVAVVDAIS---AVTGVEAKLKWPNDVLVDT----GKLAGILAEV
:.* :*:*: . : . :*****::. *:.******
Mflv_4741|M.gilvum_PYR-GCK SGP--VIVVGLGLNVEMTVDELPDPNAMSLSMLNHHA-DRTQLTASLLQE
Mvan_1722|M.vanbaalenii_PYR-1 SAP--VIVVGLGLNVSFTADELPDPNAVSLMMLGHDA-DRTALAATVLQE
Rv3279c|M.tuberculosis_H37Rv AQP--FVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLLRE
Mb3307c|M.bovis_AF2122/97 AQP--FVVLGVGLNVTQAPEEVD-PDATSLLDLGVAAPDRNRIASRLLRE
MMAR_1257|M.marinum_M AMP--YAVIGIGLNVTQAPDEIAGPAATSLLDLGVPAPDRNELAARLLRE
MUL_2631|M.ulcerans_Agy99 AMP--YAVIGIGLNVTQAPDEIAGPAATSLLDLGVPAPDRNEVAARLLRE
MLBr_00732|M.leprae_Br4923 VRP--VIVVGVGLNVTQAPKEVDGPGATSLLDLGVPAPDREQLVCWLLRE
MAV_4248|M.avium_104 SKP--VVVIGLGLNVTQSADEIDGPGATSLLDLGVAAPDRTALVSGLLRE
MAB_3626c|M.abscessus_ATCC_199 ATPHQAIVLGLGLNATFAQHELPDPNATSLTILGWADPDRDELARAVLRE
TH_0886|M.thermoresistible__bu AAPAPAVVVGIGVNVSLTEAELPEPTATSLTLLGARETDRTRLLAAVLHR
MSMEG_1822|M.smegmatis_MC2_155 ASPAPTVVIGTGLNVSVMPDDVPDSVATSLAMLTDAPVDRSALLTEFLTR
* *:* *:*. :: . * ** * ** : .* .
Mflv_4741|M.gilvum_PYR-GCK FSSRLRRWRLAGGADAGLATDYRERSTTIGTRVRALLPGDSEIIGVATGI
Mvan_1722|M.vanbaalenii_PYR-1 LSRQLHRWRAG---DPGLAADYRNASTTLGAPVRAVLPGGSEIVGVATGI
Rv3279c|M.tuberculosis_H37Rv LEARIIQW---RNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDI
Mb3307c|M.bovis_AF2122/97 LEARIIQW---RNANPQLAANYRARSLTIGSRVRVELPGGQDVVGIARDI
MMAR_1257|M.marinum_M LAARIDEF---RRAHARLSADYRARSLTIGSRVRAQLPGGREIVGIARDI
MUL_2631|M.ulcerans_Agy99 LAARIDEF---RRAHARLSADYRARSLTIGSRVRAQLPGGREIVGIARDI
MLBr_00732|M.leprae_Br4923 LDARVGQW---RSADPQLMADYRARSPIIGSRVRAELPGGKDVVGTVRGI
MAV_4248|M.avium_104 LGRRIVSWQAARGADWALAADYRARSLTIGTRVRADLPGGKHIEGTAGGI
MAB_3626c|M.abscessus_ATCC_199 LGGRIEHWRAARGLDERLLEDYRERSVTLGSRVRAELPGERELVGVAVGL
TH_0886|M.thermoresistible__bu LAERLAEWRTATGVDSPLGRAYRRHSRTLGTRVRASLPDERTLIGTATGI
MSMEG_1822|M.smegmatis_MC2_155 LADRVESWRAAGGADDRLLDDYRQCSGTLGTAVRVLLPGDRQLLGDAVDI
: :: : . * ** * :*: **. **. : * . .:
Mflv_4741|M.gilvum_PYR-GCK DDAGRLLIDTE-------GTTVTVSAADITHLRPAQD-------
Mvan_1722|M.vanbaalenii_PYR-1 DDAGRLLIDDD-------GTTVTVSAGDITHLR--HD-------
Rv3279c|M.tuberculosis_H37Rv DDQGRLCLDVG-------GRTVVVSAGDVVHLR-----------
Mb3307c|M.bovis_AF2122/97 DDQGRLCLDVG-------GRTVVVSAGDVVHLR-----------
MMAR_1257|M.marinum_M DEQGRLRLQTTPDEAGKSGETVVVAAGDVVHLR-----------
MUL_2631|M.ulcerans_Agy99 DEQGRLRLQTTPDEAGKSGETVVVAAGDVVHLR-----------
MLBr_00732|M.leprae_Br4923 DDQGRLCLKTEG---PTKGQTVVISAGDVVHLR-----------
MAV_4248|M.avium_104 DDQGRLCLDSG-------GQTVVVAAGDVVHLR-----------
MAB_3626c|M.abscessus_ATCC_199 GNDGQLRIEAAD------GTVTAVTAGDITHLRPLGDQ------
TH_0886|M.thermoresistible__bu DDAGRLRIDTGV------ESV-VVSAGDITHLRPVSGRDGSESG
MSMEG_1822|M.smegmatis_MC2_155 DESGRLLIDSEG------ERI-TVAAGDVTHLRPA---------
.: *:* :. .::*.*:.***