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ELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQTPHGQTSLLEALVADPEGQLGS ASRARFGDVLPFLVKVLAADEPLSLQAHPSAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQP FEALAGFREAARTTELLRALAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQY VSSGATEFGAEAKTVLELGERYPGDAGVLAALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNV LRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGDHLGHEVDASSG HDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPAKLFRATVGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3255c | manA | - | 100% (408) | PROBABLE MANNOSE-6-PHOSPHATE ISOMERASE MANA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHOSPHOHEXOMUTASE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3283c | manA | 0.0 | 100.00% (408) | mannose-6-phosphate isomerase |
| M. gilvum PYR-GCK | Mflv_4724 | - | 1e-176 | 73.77% (408) | mannose-6-phosphate isomerase, class I |
| M. leprae Br4923 | MLBr_00765 | manA | 0.0 | 84.67% (411) | putative mannose-6-phosphate isomerase |
| M. abscessus ATCC 19977 | MAB_3601c | - | 1e-146 | 63.79% (406) | mannose-6-phosphate isomerase ManA |
| M. marinum M | MMAR_1287 | manA | 0.0 | 88.73% (408) | mannose-6-phosphate isomerase ManA |
| M. avium 104 | MAV_4217 | manA | 0.0 | 83.82% (408) | mannose-6-phosphate isomerase, class I |
| M. smegmatis MC2 155 | MSMEG_1836 | manA | 1e-168 | 76.46% (378) | mannose-6-phosphate isomerase, class I |
| M. thermoresistible (build 8) | TH_0473 | manA | 1e-171 | 73.07% (401) | PROBABLE MANNOSE-6-PHOSPHATE ISOMERASE MANA (PHOSPHOMANNOSE |
| M. ulcerans Agy99 | MUL_2600 | manA | 0.0 | 88.97% (408) | mannose-6-phosphate isomerase ManA |
| M. vanbaalenii PYR-1 | Mvan_1739 | - | 1e-175 | 72.30% (408) | mannose-6-phosphate isomerase, class I |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4724|M.gilvum_PYR-GCK MHLLRGAVRTYAWGSRTAIAEFVGGPSPTPHPEAELWFGAHPGDPAWLQT
Mvan_1739|M.vanbaalenii_PYR-1 MHLLKGAVRTYAWGSRTAIAEFVGAPSPTAHPEAELWFGAHPGDPAYLKT
TH_0473|M.thermoresistible__bu -------VRTYAWGSRTAIADFTGRPSPTMHPEAELWFGAHPADPAYLQT
MSMEG_1836|M.smegmatis_MC2_155 -----------------------------MHPEAELWFGAHPADPAWLQT
Rv3255c|M.tuberculosis_H37Rv MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQT
Mb3283c|M.bovis_AF2122/97 MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQT
MMAR_1287|M.marinum_M MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLET
MUL_2600|M.ulcerans_Agy99 MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLET
MLBr_00765|M.leprae_Br4923 MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDSVWLQA
MAV_4217|M.avium_104 MELLRGALRTYAWGSRTAIAEFTERPVPAAHPEAELWFGAHPGDPAWLET
MAB_3601c|M.abscessus_ATCC_199 MNLLRGAIRTYAWGSRTAIAEFTGRPTPTPHPEAELWLGAHPADPAYLET
*******:****.*..:*::
Mflv_4724|M.gilvum_PYR-GCK DDGERSLLDALRADPEGELGSAVRGRFGDTLPFLVKVLAADEPLSLQAHP
Mvan_1739|M.vanbaalenii_PYR-1 DDGDRSLLDALRADPEGELGAAVRGRFGDTLPFLVKVLAADEPLSLQAHP
TH_0473|M.thermoresistible__bu DDGEQSLLDALAADPEGQLGPVARGRFGDSVPFLVKVLAADEPLSLQAHP
MSMEG_1836|M.smegmatis_MC2_155 DDGERSLLQALADDPEGQLGSTAVARFGDALPFLVKVLAADEPLSLQAHP
Rv3255c|M.tuberculosis_H37Rv PHGQTSLLEALVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHP
Mb3283c|M.bovis_AF2122/97 PHGQTSLLEALVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHP
MMAR_1287|M.marinum_M DGGESSLLETLSADPEGQLGPGARARFGDVLPFLVKVLAADEPLSLQAHP
MUL_2600|M.ulcerans_Agy99 DGGESSLLETLSADPEGQLGPGARARFGDVLPFLVKVLAADEPLSLQAHP
MLBr_00765|M.leprae_Br4923 ANGETSLLEALVADPEGQLGSVSRARFGDVLPFLVKVLAADEPLSLQAHP
MAV_4217|M.avium_104 DNGEITLLDALRADPEGQLGPGSRARFGDVLPFLVKVLAADEPLSLQAHP
MAB_3601c|M.abscessus_ATCC_199 GGGAESLLEVVAADPTGQLGAASVAEFGDQLPFLLKVLAADEPLSLQAHP
* :**:.: ** *:**. ..*** :***:***************
Mflv_4724|M.gilvum_PYR-GCK STEQAVEGFAREDRMGIPVTAPDRNYRDPSHKPEIIVALSQFEALAGFRP
Mvan_1739|M.vanbaalenii_PYR-1 STEQAVEGFAREDRLGIPISAPDRNYRDRSHKPEIIVALSQFEALAGFRP
TH_0473|M.thermoresistible__bu SAEQAAEGYAREDQLGIPVSAPMRNYRDRNHKAELLVALGPFEALAGFRP
MSMEG_1836|M.smegmatis_MC2_155 SAAQAQEGFEREDRLQIPISSPVRNYRDRSHKPELLVALEEFHALAGFRP
Rv3255c|M.tuberculosis_H37Rv SAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFRE
Mb3283c|M.bovis_AF2122/97 SAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFRE
MMAR_1287|M.marinum_M SAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFRQ
MUL_2600|M.ulcerans_Agy99 SAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFRQ
MLBr_00765|M.leprae_Br4923 STKQAVEGYLREERLGIPVSSPERNYRDTSHKPELLVALQSFEALAGFRQ
MAV_4217|M.avium_104 SAEQAAEGYLREERLGIPLNSPVRNYRDTSHKPELLVALYPFEALAGFRP
MAB_3601c|M.abscessus_ATCC_199 SAQQAADGFAREEAAGVPLNSPVRNYRDRNHKPELVVALDRFEALAGFRD
*: ** :*: **: :*:.:* ***** .**.*::*** *.******
Mflv_4724|M.gilvum_PYR-GCK AARSVELMTALGVADLDPYIGLLSGQRDEDGLRALFTTWITCPQPDLDLL
Mvan_1739|M.vanbaalenii_PYR-1 AARSVELMRALGVADLDPFISLLHGQRDEDGLRALFTTWITFPQPDLDVL
TH_0473|M.thermoresistible__bu VAETVELLQALSVPELQTAINLLDGQPDADGLRTVFTTWITAPQPDLDAL
MSMEG_1836|M.smegmatis_MC2_155 VARTVELMRTLAVTDLDPYINLLSDQSDADGLRALFTTWITAPQPDLDVL
Rv3255c|M.tuberculosis_H37Rv AARTTELLRALAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVL
Mb3283c|M.bovis_AF2122/97 AARTTELLRALAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVL
MMAR_1287|M.marinum_M AARTRELLQALAVSDLDPFIDLLFDQSDADGLRALFTTWITAPQPDIDVL
MUL_2600|M.ulcerans_Agy99 AARTRELLQALAVSDLDPFIDLLFDQSDADGLRALFTTWITAPQPDIDVL
MLBr_00765|M.leprae_Br4923 SSRTAELLTALAVSDLDPFIHLLSDQSDADGLRALFTTWITAPQTDIDML
MAV_4217|M.avium_104 ASRTVELLRALAVSDLDPFIELLGDQSDADGLRALFTTWITAPQPDIDVL
MAB_3601c|M.abscessus_ATCC_199 PGDTVDLFRALDVEALTPYVNLLAGQSDADGLRALFTTWITLPQPSLDVL
. : :*: :* * * . : ** * ****::****** **..:* *
Mflv_4724|M.gilvum_PYR-GCK VPAVIDGAINYVRSGAQEFAREAKTVLELGERYPGDAGVLASLLLNRLSL
Mvan_1739|M.vanbaalenii_PYR-1 VPAVIDGAIGYVRSGEREFAREAKTVLELGERYPGDAGVLCSMLLNRLSL
TH_0473|M.thermoresistible__bu VPAVLEGAVRYVQSGHTRFVAEAKTVLELGERYPGDAGVLASLLLNRISL
MSMEG_1836|M.smegmatis_MC2_155 VPAVLDGAINYIRSGEKAFAAEAKTVLELGERYPGDAGVLASLLLNRIVL
Rv3255c|M.tuberculosis_H37Rv VPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVLAALLLNRISL
Mb3283c|M.bovis_AF2122/97 VPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVLAALLLNRISL
MMAR_1287|M.marinum_M VPAVLDGAIHYVSSGATEFVAEAKTVLELGERYPGDAGVLAALLLNRISL
MUL_2600|M.ulcerans_Agy99 VPAVLDGAIQYVSSGATEFVAEAKTVLELGERYPGDAGVLAALLLNRISL
MLBr_00765|M.leprae_Br4923 VPAVLEGAIAYVSSGATEFLAEVKTVMELGERYPGDAGVLASLLLNRISL
MAV_4217|M.avium_104 VPAVLDGAIAYLSSGATEFAAEAKTVLELGERYPGDAGVLAALLLNRVSL
MAB_3601c|M.abscessus_ATCC_199 VPAVLDGAVRYLSSDDVRFVGEARTLLELGERYPADAGVLASLLLNRLTL
****::**: *: *. * *.:*::*******.*****.::****: *
Mflv_4724|M.gilvum_PYR-GCK APGEALYLPAGNLHAYLEGVGVEVMANSDNVLRGGLTPKHVDVPELLRVL
Mvan_1739|M.vanbaalenii_PYR-1 APGEALYLPAGNLHAYLHGIGVEVMANSDNVLRGGLTPKHVDVPELLRVL
TH_0473|M.thermoresistible__bu KAGEGIYLPAGNLHAYLHGIGVEVMANSDNVLRGGLTPKHVDVPELLRVL
MSMEG_1836|M.smegmatis_MC2_155 QPGEGLYLPAGNLHAYLHGVGVEVMANSDNVLRGGLTPKHVDVPELLRVL
Rv3255c|M.tuberculosis_H37Rv APGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVL
Mb3283c|M.bovis_AF2122/97 APGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVL
MMAR_1287|M.marinum_M APGEAIFLPAGNLHAYLRGFALEVMANSDNVLRGGLTPKHVDVPELLRVL
MUL_2600|M.ulcerans_Agy99 APGEAIFLPAGNLHAYLRGFALEVMANSDNVLRGGLTPKHVDVPELLRVL
MLBr_00765|M.leprae_Br4923 TPGEAIFLPAGNLHAYLRGVGVEVMANSDNVLRGGLTPKHVDVPELLRVL
MAV_4217|M.avium_104 APGEAIFVSAGNLHTYLRGFAVEVMANSDNVLRGGLTPKHVDVPELLRVL
MAB_3601c|M.abscessus_ATCC_199 EPGEGIYLPAGNLHAYLRGLAVEIMANSDNVLRGGLTPKHVDVPELLRVL
.**.:::.*****:*:.*..:*:**************************
Mflv_4724|M.gilvum_PYR-GCK DFTPAEDVLVVPETIRGGAEIVYPTPAPEFAVSILHLDGESLGHEIDAPT
Mvan_1739|M.vanbaalenii_PYR-1 DFTPAEDVYVRPETVRDGTEIVYPTPAPEFSVSVLGIEGERLGHEIDAPT
TH_0473|M.thermoresistible__bu DFTPTAAADLHPAVTRNDSELVYHTPAPEFAVSVVTVDGDQLGHEIDAPS
MSMEG_1836|M.smegmatis_MC2_155 DFTPTPEDRLRPVIVHDAKELVYQTPAPEFAVSVLRLDGEQLGHEIDAQS
Rv3255c|M.tuberculosis_H37Rv DFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGDHLGHEVDASS
Mb3283c|M.bovis_AF2122/97 DFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGDHLGHEVDASS
MMAR_1287|M.marinum_M DFAPTAASDLRPPVRREGPELVYETPTDEFAVALLVLDGDYLGHEIDASS
MUL_2600|M.ulcerans_Agy99 DFAPTAASDLRPPVRREGPELVYETPTDEFAVALLVLDGDYLGHEIDASS
MLBr_00765|M.leprae_Br4923 DFNPTPEEALRPPTRCEGFAVVYETPTDEFEVALLALDGDYLGHEVDASP
MAV_4217|M.avium_104 DFAPTTEDQLRPRVRREGFGRIYETPTDEFAVALLELEDEYVGHEVDATC
MAB_3601c|M.abscessus_ATCC_199 DFSPASEAHLHVETVTDGAQTRYRTPAREFALSRFDLAA---GEPTQVGI
** *: : : **: ** : . : *. :.
Mflv_4724|M.gilvum_PYR-GCK R--HDGPQILLCTDGAATVQANGSAVALKRGAAAWVGAGDGPIRLSAQEP
Mvan_1739|M.vanbaalenii_PYR-1 C--HDGPQILLCTQGAATVHAKADAVVLEKGAAAWVSADDGPIRLVAQEP
TH_0473|M.thermoresistible__bu R--HDGPQILLCTEGATIVRAKTNSVTLERGAAAWVSADDGPIRLEAHKP
MSMEG_1836|M.smegmatis_MC2_155 R--HDGPQLLLCTEGSLKVHAKAGQLELSRGEAAWVAADDGPIRLTAELP
Rv3255c|M.tuberculosis_H37Rv G--HDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQP
Mb3283c|M.bovis_AF2122/97 G--HDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQP
MMAR_1287|M.marinum_M S--HEGPQILLCTEGSTVVHGKSQSLTLEHGNAAWVAADDGPIRLLAQEP
MUL_2600|M.ulcerans_Agy99 S--HEGPQILLCTEGSTVVHGKSQSLTLEHGNAAWVAADDGPIRLLAQEP
MLBr_00765|M.leprae_Br4923 HDVSQGPQILLCTEGEITVHGKFQALTVERGMAVWMAADDGPIRLVAQQP
MAV_4217|M.avium_104 S--HDGPQILLCIQGCTTVHGKSGSLRLKRGMAAWVAADDAPIRLVAHEP
MAB_3601c|M.abscessus_ATCC_199 K----GPRILLCTQGDVTLDGSGAGLKVRAGQSVWVPADGGSVTLTGRSD
**::*** :* : .. : : * :.*: *....: * .
Mflv_4724|M.gilvum_PYR-GCK TKLFRVTVGI--
Mvan_1739|M.vanbaalenii_PYR-1 TRLFRVTVGI--
TH_0473|M.thermoresistible__bu TKLFRVTVGI--
MSMEG_1836|M.smegmatis_MC2_155 AAMFRVTVGI--
Rv3255c|M.tuberculosis_H37Rv AKLFRATVGL--
Mb3283c|M.bovis_AF2122/97 AKLFRATVGL--
MMAR_1287|M.marinum_M TKLFRATVGL--
MUL_2600|M.ulcerans_Agy99 TKLFRATVGL--
MLBr_00765|M.leprae_Br4923 AKLFRATVGL--
MAV_4217|M.avium_104 TKLFRATVGL--
MAB_3601c|M.abscessus_ATCC_199 ARVFMATVDADA
: :* .**.