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PQGNPLAVPNDGLTTRARRNMPILAVHTGEGKGKSTAAFGMALRAWNAGLDIAVFQFVKSAKWKVGEEAA FRQLGRLHDQHGIGGAVEWHKMGAGWSWTRTSRKAGTDVDRAAAAADGWAEIALRLATQRHDFYLLDEFT YPLKWGWLDVDEVVDVLRARPGHQHVVITGRDAPQRLVAAADLVTEMTKVKHPMDAGRKGQKGIEW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2849c | cobO | - | 100% (207) | cob(I)yrinic acid a,c-diamide adenosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2874c | cobO | 1e-121 | 99.52% (207) | cob(I)yrinic acid a,c-diamide adenosyltransferase |
| M. gilvum PYR-GCK | Mflv_4049 | - | 1e-101 | 81.64% (207) | cob(I)yrinic acid a,c-diamide adenosyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3156c | - | 4e-97 | 78.74% (207) | cob(I)yrinic acid a,c-diamide adenosyltransferase |
| M. marinum M | MMAR_1884 | cobO | 1e-103 | 84.06% (207) | cob(I)alamin adenosyltransferase CobO |
| M. avium 104 | MAV_3705 | cobO | 1e-100 | 83.09% (207) | cob(I)yrinic acid a,c-diamide adenosyltransferase |
| M. smegmatis MC2 155 | MSMEG_2616 | cobO | 2e-95 | 80.40% (199) | cob(I)yrinic acid a,c-diamide adenosyltransferase |
| M. thermoresistible (build 8) | TH_1497 | cobA | 1e-100 | 80.68% (207) | PROBABLE COB(I)ALAMIN ADENOSYLTRANSFERASE COBO (CORRINOID |
| M. ulcerans Agy99 | MUL_2112 | cobO | 1e-103 | 84.06% (207) | cob(I)yrinic acid a,c-diamide adenosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_2303 | - | 1e-101 | 81.64% (207) | cob(I)yrinic acid a,c-diamide adenosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2849c|M.tuberculosis_H37Rv MPQGNPLAVPNDGLTTRARRNMPILAVHTGEGKGKSTAAFGMALRAWNAG
Mb2874c|M.bovis_AF2122/97 MPQGNPLAVPNDGLTTRARRNMPILAVHTGEGKGKSTAAFGMALRAWNAG
MMAR_1884|M.marinum_M MPQGNPAQVPDDGLTTRQRRNTPVLAVHTGDGKGKSTAAFGMALRAWNVG
MUL_2112|M.ulcerans_Agy99 MPQGNPAQVPDDGLTTRQRRNTPVLAVHTGDGKGKSTAAFGMALRAWNVG
MAV_3705|M.avium_104 MPQGVPLQVPDDGLTTRARRHTPVLAVHTGAGKGKSTAAFGMALRAWNAG
Mflv_4049|M.gilvum_PYR-GCK MPQGQPLTVPDDGLTTRARRNAPLLAVHTGPGKGKSTAAFGMALRAWNQG
Mvan_2303|M.vanbaalenii_PYR-1 MPQGSPLTVPDDGLTTRARRNAPLLAVHTGPGKGKSTAAFGMALRAWNQG
MSMEG_2616|M.smegmatis_MC2_155 -------MVPDDGLTTRARRNAPVLAVHTGPGKGKSTAAFGMALRAWNQG
TH_1497|M.thermoresistible__bu MPQGQPTTVPDDGLTTRARRNLPVLAVHTGPGKGKSTAAFGMALRAWNQG
MAB_3156c|M.abscessus_ATCC_199 MPQGQPLVVPQDGLTTKARRNAPILAVHTGAGKGKSTAAFGMALRAWHHG
**:*****: **: *:****** ****************: *
Rv2849c|M.tuberculosis_H37Rv LDIAVFQFVKSAKWKVGEEAAFRQLGRLHDQHGIGGAVEWHKMGAGWSWT
Mb2874c|M.bovis_AF2122/97 LDIAVFQFVKSAKWKVGEEAAFRQLGRLHDQHGIGGAVEWHKMGAGWSWT
MMAR_1884|M.marinum_M LDVAVFQFVKSAKWKVGEETAFQHLGRLHDQQGIGAAVQWHKMGAGWSWS
MUL_2112|M.ulcerans_Agy99 LDVAVFQFVKSAKWKVGEETAFQHLGRLHDQQGIGAAVQWHKMGAGWSWS
MAV_3705|M.avium_104 LSVAVFQFVKSAKWKVGEEAAFAALGRLHEEQRIGAPVEWHKMGAGWSWT
Mflv_4049|M.gilvum_PYR-GCK FDIAVFQFVKSAKWKVGEESALTELGRAHDERGVGGPVEWHKMGSGWSWT
Mvan_2303|M.vanbaalenii_PYR-1 FDIAVFQFVKSAKWKVGEETALRELGRAHDERGVGGPVEWHKMGSGWSWT
MSMEG_2616|M.smegmatis_MC2_155 FRVAVFQFVKSAKWKVGEEAVFRELGRLHDEHGAGGPVEWHKMGSGWSWT
TH_1497|M.thermoresistible__bu FDIGVFQFVKSAKWKVGEEAAFRRLGALHTEHGVGGPVEWHKMGAGWSWA
MAB_3156c|M.abscessus_ATCC_199 ADVAVFQFVKSAKWRVGEESVFGELAKLHDEHGIGGSVQWHKMGSGWSWS
:.**********:****:.: *. * :: *..*:*****:****:
Rv2849c|M.tuberculosis_H37Rv RTSRKAGTDVDRAAAAADGWAEIALRLATQRHDFYLLDEFTYPLKWGWLD
Mb2874c|M.bovis_AF2122/97 RTSRKAGTDVDRAAAAADGCAEIALRLATQRHDFYLLDEFTYPLKWGWLD
MMAR_1884|M.marinum_M ---RKVGSDDDHAAAAADGWAEIARRLAAQRHQFYVLDEFTYPLKWGWVD
MUL_2112|M.ulcerans_Agy99 ---RKVGSDDDHAAAAADGWAEIARRLAAQRHQFYVLDEFTYPLKWGWVD
MAV_3705|M.avium_104 ---RKAGSDDDHAAAAADGWAEIARRLAAARHDFYVLDEFTYPLKWGWVD
Mflv_4049|M.gilvum_PYR-GCK ---RKSGTEVDHAAAAADGWAEISRRLAEQRHDFYVLDEFTYPLKWGWVD
Mvan_2303|M.vanbaalenii_PYR-1 ---RKAGTEIDHASAAADGWAEISRRLSEERHDFYVLDEFTYPLKWGWLD
MSMEG_2616|M.smegmatis_MC2_155 ---RKHGSDDDHAAAAADGWAEIKRRLAAEQHDFYVLDEFTYPLKWGWVD
TH_1497|M.thermoresistible__bu ---RKQGTEQDHAAAAADGWAEIKRRLAAERHDFYVLDEFTYPLKWGWIP
MAB_3156c|M.abscessus_ATCC_199 ---RKAGTETDHAADAAAGWAEIARRLAAQEHGFYVLDEFTYPLKWGWVD
** *:: *:*: ** * *** **: .* **:************:
Rv2849c|M.tuberculosis_H37Rv VDEVVDVLRARPGHQHVVITGRDAPQRLVAAADLVTEMTKVKHPMDAGRK
Mb2874c|M.bovis_AF2122/97 VDEVVDVLRARPGHQHVVITGRDAPQRLVAAADLVTEMTKVKHPMDAGRK
MMAR_1884|M.marinum_M VGEVVDVLLARPGYQHVVITGRDAPAQLIAAADLVTEMTKVKHPMDAGRK
MUL_2112|M.ulcerans_Agy99 VGEVVDVLLARPGYQHVVITGRDAPAQLIAAADLVTEMTKVKHPMDAGRK
MAV_3705|M.avium_104 VDEVVSVLAGRPGHQHVVITGRDAPQRLIDAADLVTEMANVKHPMDAGRK
Mflv_4049|M.gilvum_PYR-GCK VDDVVETLARRPGNQHVVITGRDAPQALLDAADLVTEMTKVKHPMDAGRK
Mvan_2303|M.vanbaalenii_PYR-1 VDDVVSTLTARPGTQHVVITGRDAPQALVDAADLVTEMTKVKHPMDVGRK
MSMEG_2616|M.smegmatis_MC2_155 VDDVVSTLTERPGRQHVVITGRDAPQALIDAADLVTEMTKIKHPMDVGRK
TH_1497|M.thermoresistible__bu VDEVIEVLTARPGTQHVVITGRDAPAALIEAADLVTEMTKIKHPMDAGRK
MAB_3156c|M.abscessus_ATCC_199 PDEVVEVLRSRPGMQHVVITGRDAPQQLLDAADLVTEMTKVKHPMDQGRK
.:*:..* *** *********** *: ********:::***** ***
Rv2849c|M.tuberculosis_H37Rv GQKGIEW
Mb2874c|M.bovis_AF2122/97 GQKGIEW
MMAR_1884|M.marinum_M GQKGIEW
MUL_2112|M.ulcerans_Agy99 GQKGIEW
MAV_3705|M.avium_104 GQKGIEW
Mflv_4049|M.gilvum_PYR-GCK GQKGIEW
Mvan_2303|M.vanbaalenii_PYR-1 GQKGIEW
MSMEG_2616|M.smegmatis_MC2_155 GQKGIEW
TH_1497|M.thermoresistible__bu GQKGIEW
MAB_3156c|M.abscessus_ATCC_199 GQRGIEW
**:****