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M. tuberculosis H37Rv Rv2761c (hsdS)

SRVEKVEKVRLGDHLDFSNGHTSGHTSPASEPGGRYPVYGANGVIGYSAQHNARGPLIVVGRVGSYCGSL
RYCDSDVWVTDNALACRAKKPEETRYWYYALLGFGLNRYRAGSGQPLLSQGVLRNVSVSAVAAPDRPRIG
EILGAFDDKIAANDRVIEAAEALMLAIVGRLSAYVPLSSLASRSTACLDAQHFDSTVAHYSFAAFDGGAQ
PSRVGGRTIRSAKLVVSQPCVLFPKLNPRIPRIWNITSLPSEMALASTEFVVLRPVGVDTSALWAALRQP
DVLAELRQLVGGMTGSRQRIQPTQLLRVWVRDVRRLTPGHAAAIANLGALCNERRIESARLASCRDALLP
LLMSGIDGLPAGR*

Operon Prediction Model: Genebank

Paralogs

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv2761c	hsdS	-	100% (364)	POSSIBLE TYPE I RESTRICTION/MODIFICATION SYSTEM SPECIFICITY DETERMINANT HSDS (S PROTEIN)
M. tuberculosis H37Rv	Rv2755c	hsdS.1	5e-05	29.89% (87)	type I restriction/modification system specificity

Closest Orthologs (e-value cutoff: 1e-4)

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	Mb2782c	hsdS	0.0	100.00% (364)	type I restriction/modification system specificity
M. gilvum PYR-GCK	Mflv_0804	-	2e-09	31.58% (114)	restriction modification system DNA specificity subunit
M. leprae Br4923	-	-	-	-	-
M. abscessus ATCC 19977	-	-	-	-	-
M. marinum M	MMAR_1960	hsdS	1e-118	62.25% (347)	type I restriction/modification system specificity
M. avium 104	-	-	-	-	-
M. smegmatis MC2 155	-	-	-	-	-
M. thermoresistible (build 8)	-	-	-	-	-
M. ulcerans Agy99	-	-	-	-	-
M. vanbaalenii PYR-1	-	-	-	-	-

CLUSTAL 2.0.9 multiple sequence alignment


Rv2761c|M.tuberculosis_H37Rv      MSRVEKVEKVRLGDHLDFSNGHTSGHTSPASEPGGRYPVYGANGVIGYSA
Mb2782c|M.bovis_AF2122/97         MSRVEKVEKVRLGDHLDFSNGHTSGHTSPASEPGGRYPVYGANGVIGYSA
MMAR_1960|M.marinum_M             ---------MRLGEHLEFR----SGSCSPPRRARGRVPVYGANGPIGFAA
Mflv_0804|M.gilvum_PYR-GCK        -------MKWPEVPIDSFCRPKQWPTISQSQLTPTGYPVYGANGQIGWYS
                                                  .*         * .  .    ******* **: :

Rv2761c|M.tuberculosis_H37Rv      QHNARGPLIVVGRVGSYCGSLRYCDSDVWVTDNALACRAKKPE--ETRYW
Mb2782c|M.bovis_AF2122/97         QHNARGPLIVVGRVGSYCGSLRYCDSDVWVTDNALACRAKKPE--ETRYW
MMAR_1960|M.marinum_M             EHNVSGPLIVVGRVGSYCGSVRYCDSDVWVTDNAYVCRANDPA--ETRYW
Mflv_0804|M.gilvum_PYR-GCK        TYNHESETVLITCRGATCGTVNVSPPKSYVTGNAMALDSLDEARIHLRYL
                                   :*  .  :::   *: **::. . .. :**.** .  : .    . ** 

Rv2761c|M.tuberculosis_H37Rv      YYALLGFGLNRYRAGSGQPLLSQGVLRNVSVSAVAAPDRPRIGEILGAFD
Mb2782c|M.bovis_AF2122/97         YYALLGFGLNRYRAGSGQPLLSQGVLRNVSVSAVAAPDRPRIGEILGAFD
MMAR_1960|M.marinum_M             YYALQTCRLNEHRAGSGQPLLNQRTLREVSVHVAQAPERRRIAEVLGALD
Mflv_0804|M.gilvum_PYR-GCK        VHVLTPERLRRSITGSAQPQITRESLKAITVPLPPLADQRRIAAILDQAD
                                   :.*    *..  :**.** :.:  *: ::*     .:: **. :*.  *

Rv2761c|M.tuberculosis_H37Rv      DKIAANDRVIEAAEALMLAIVGRLSAYVPLSSLASRSTACLDAQHFDSTV
Mb2782c|M.bovis_AF2122/97         DKIAANDRVIEAAEALMLAIVGRLSAYVPLSSLASRSTACLDAQHFDSTV
MMAR_1960|M.marinum_M             DKIANNERVIEAAEALMVAMVGSVDARVALSGLARRSTKLVNPADFDDVV
Mflv_0804|M.gilvum_PYR-GCK        RLRSHRHGLLRRYSELKRAGFASMFAGISSSGKLGDYGEVQGGLQVSRKR
                                     : .. ::.  . *  * .. : * :. *.         .  ...   

Rv2761c|M.tuberculosis_H37Rv      AHYSFAAFDGGAQPSRVGGRTIRSAK-LVVSQPCVLFPKLNPRIPRIWNI
Mb2782c|M.bovis_AF2122/97         AHYSFAAFDGGAQPSRVGGRTIRSAK-LVVSQPCVLFPKLNPRIPRIWNI
MMAR_1960|M.marinum_M             AHFSLPAFDAGAHARPVAGASVKSGK-FHLSEPCVLFAKLNPRVPRIWNV
Mflv_0804|M.gilvum_PYR-GCK        ESLPLERPYLRVANIYRGKLDLGEVKTIRVTEAESMRVRLEPGDLLFVEG
                                     .:      .     .   : . * : :::.  :  :*:*    : : 

Rv2761c|M.tuberculosis_H37Rv      TSLPSEMALASTEFVVLRPVGVDTSALWAALRQPDVLAELRQLVGGMTGS
Mb2782c|M.bovis_AF2122/97         TSLPSEMALASTEFVVLRPVGVDTSALWAALRQPDVLAELRQLVGGMTGS
MMAR_1960|M.marinum_M             VRLPPQMALASCEFVVLSPLGVDTSVLWSALRQPEVSTSLAQLVAGTSGS
Mflv_0804|M.gilvum_PYR-GCK        HANPNEVGRVAEWNGSVPDCLHQNHLIRVRLDRSAVEPTYAEAWFNSRDG
                                     * ::. .:     :     :.  :   * :. * .   :   .  ..

Rv2761c|M.tuberculosis_H37Rv      RQRIQPTQLLRVWVRDVRR-LTPGHAAAIANLGALCNERRIESARLASCR
Mb2782c|M.bovis_AF2122/97         RQRIQPTQLLRVWVRDVRR-LTPGHAAAIANLGALCNERRIESARLASCR
MMAR_1960|M.marinum_M             HQRIGPKDLLDLQVPDVRR-LGAAQSATITDLGALCHARRGQCAQLAALR
Mflv_0804|M.gilvum_PYR-GCK        SMHFQRAGKTTSGLNTINASQLRAAPLPVPPISLQREYVTVANAIDNHLR
                                    ::         :  :.     . . .:. :.   .      *     *

Rv2761c|M.tuberculosis_H37Rv      DALLPLLMSGIDGLPAGR----------
Mb2782c|M.bovis_AF2122/97         DALLPLLMSGIDGLPAGR----------
MMAR_1960|M.marinum_M             DALLPGLVTGEVAVSGGELLLASPLGTP
Mflv_0804|M.gilvum_PYR-GCK        DQTMQSELVDELFVSLQSRAFSGQL---
                                  *  :   : .   :.