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TEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVDTPGLHRPRTLL GKRLNDLVRETYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTLVVIVTKIDKVPKEKVVAQLVA VSELVTNAAEIVPVSAMTGDRVDLLIDVLAAALPAGPAYYPDGELTDEPEEVLMAELIREAALQGVRDEL PHSLAVVIDEVSPREGRDDLIDVHAALYVERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLR VKVAKNWQRDPKQLGRLGF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2364c | era | - | 100% (300) | GTP-binding protein Era |
| M. tuberculosis H37Rv | Rv1713 | engA | 1e-07 | 29.32% (191) | GTP-binding protein EngA |
| M. tuberculosis H37Rv | Rv2725c | hflX | 1e-05 | 27.85% (237) | GTP-binding protein HflX |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2385c | era | 1e-169 | 100.00% (300) | GTP-binding protein Era |
| M. gilvum PYR-GCK | Mflv_2710 | era | 1e-135 | 79.80% (302) | GTP-binding protein Era |
| M. leprae Br4923 | MLBr_00631 | era | 1e-137 | 81.40% (301) | GTP-binding protein Era |
| M. abscessus ATCC 19977 | MAB_1672 | era | 1e-133 | 78.74% (301) | GTP-binding protein Era |
| M. marinum M | MMAR_3674 | era | 1e-148 | 86.96% (299) | GTP-binding protein Era |
| M. avium 104 | MAV_2029 | era | 1e-150 | 89.00% (300) | GTP-binding protein Era |
| M. smegmatis MC2 155 | MSMEG_4493 | era | 1e-141 | 82.67% (300) | GTP-binding protein Era |
| M. thermoresistible (build 8) | TH_1204 | bex | 1e-140 | 82.89% (298) | PROBABLE GTP-BINDING PROTEIN ERA |
| M. ulcerans Agy99 | MUL_3617 | era | 1e-147 | 86.62% (299) | GTP-binding protein Era |
| M. vanbaalenii PYR-1 | Mvan_3828 | era | 1e-135 | 80.40% (301) | GTP-binding protein Era |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2364c|M.tuberculosis_H37Rv ------------------MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVA
Mb2385c|M.bovis_AF2122/97 ------------------MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVA
MAV_2029|M.avium_104 ------------------MTEFRSGFVCLVGRPNTGKSTLTNALVGTKVA
MMAR_3674|M.marinum_M -----------------MTSEFHSGFVCLVGRPNTGKSTLTNALVGTKVA
MUL_3617|M.ulcerans_Agy99 -----------------MTSEFHSGFVCLVGRPNTGKSTLTNALVGTKVA
MLBr_00631|M.leprae_Br4923 ----------------MDMAEFRSGFVCLIGRPNTGKSTLTNALVGTKVA
Mflv_2710|M.gilvum_PYR-GCK ----------------MSDSEFRSGFVCFVGRPNTGKSTLTNALVGTKVA
Mvan_3828|M.vanbaalenii_PYR-1 ---------------MTDEAEFRSGFVCFVGRPNTGKSTLTNALVGTKVA
MSMEG_4493|M.smegmatis_MC2_155 ----------------MALTEFRSGFVCFVGRPNTGKSTLTNALVGQKVA
MAB_1672|M.abscessus_ATCC_1997 ----------------MSSPEFRSGFVCFVGRPNTGKSTLTNALVGQKVA
TH_1204|M.thermoresistible__bu VTAQDVSPSGSGPEDSRGNGEFRSGFVCLVGRPNTGKSTLTNALVGAKVA
**:*****::**************** ***
Rv2364c|M.tuberculosis_H37Rv ITSTRPQTTRHAIRGIVHSDD-FQIILVDTPGLHRPRTLLGKRLNDLVRE
Mb2385c|M.bovis_AF2122/97 ITSTRPQTTRHAIRGIVHSDD-FQIILVDTPGLHRPRTLLGKRLNDLVRE
MAV_2029|M.avium_104 ITSMRPQTTRHTIRGIVHRDD-FQIILVDTPGLHRPRTLLGKRLNDLVRD
MMAR_3674|M.marinum_M ITSMRPQTTRHTIRGIVHRES-FQIILVDTPGLHRPRTLLGKRLNDLVRD
MUL_3617|M.ulcerans_Agy99 ITSMRPQTTRHTIRGIVHRES-FQIILVDTPGLHRPRTLLGKRLNDLVRD
MLBr_00631|M.leprae_Br4923 ITSMKPQTTRHTIRGIVHREGNFQIVLVDTPGLHRPRTLLGKRLNDLVRD
Mflv_2710|M.gilvum_PYR-GCK ITSNRPQTTRHTIRGIVHRDD-FQIVLVDTPGLHRPRTLLGQRLNELVKD
Mvan_3828|M.vanbaalenii_PYR-1 ITSNRPQTTRHTIRGIVHRDE-FQIVLVDTPGLHRPRTLLGQRLNELVKD
MSMEG_4493|M.smegmatis_MC2_155 ITSNRPQTTRHTIRGIVHRED-FQIILVDTPGLHRPRTLLGQRLNDLVKD
MAB_1672|M.abscessus_ATCC_1997 ITSNRPQTTRHTIRGIVHREN-FQIVLVDTPGLHRPRTLLGQRLNDLVRD
TH_1204|M.thermoresistible__bu ITSNRPQTTRHTIRGIVHREN-FQIVLVDTPGLHRPRTLLGQRLNDLVKD
*** :******:****** : ***:***************:***:**::
Rv2364c|M.tuberculosis_H37Rv TYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTLVVIVTKIDKVP
Mb2385c|M.bovis_AF2122/97 TYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTLVVIVTKIDKVP
MAV_2029|M.avium_104 TYAEVDVIGLCIPADEAIGPGDRWIVEQIRATAPK-TTLVAIVTKIDKVP
MMAR_3674|M.marinum_M TYSEVDVIGLCIPADESIGPGDRWIIEQIAATAPK-VKLVVIVTKIDKVP
MUL_3617|M.ulcerans_Agy99 TYSEVDVIGLCIPADESIGPGDRWIIEQIAATAPK-VKLVVIVTKIDKVP
MLBr_00631|M.leprae_Br4923 TYTEVDLIGLCIPADEATGPGDRWIVNQIRSVAPK-TILVVIVTKIDKVP
Mflv_2710|M.gilvum_PYR-GCK TYSEVDVIGMCIPADEKIGPGDRWIYEQIRAVAPR-TTLIAIVTKIDKVS
Mvan_3828|M.vanbaalenii_PYR-1 TYSEVDVIGMCIPADEKIGPGDRWIYEQIRAVAPR-TTLIAIVTKIDKVS
MSMEG_4493|M.smegmatis_MC2_155 TYSEVDVIGMCIPADEAIGPGDRWIYQQIRAVAPR-TTLIGIVTKIDKVP
MAB_1672|M.abscessus_ATCC_1997 TYSEVDVIGLCIPADEGIGPGDKWIYEQIKLVAPR-TTLIAIVTKIDKVS
TH_1204|M.thermoresistible__bu TYSTVDVIGLCIPADEAIGPGDRWIHDQIRAVAPD-TTLVAIVTKIDKVP
**: **:**:****** ****:** :*: ..* . *: ********.
Rv2364c|M.tuberculosis_H37Rv KEKVVAQLVAVSELVTNAAEIVPVSAMTGDRVDLLIDVLAAALPAGPAYY
Mb2385c|M.bovis_AF2122/97 KEKVVAQLVAVSELVTNAAEIVPVSAMTGDRVDLLIDVLAAALPAGPAYY
MAV_2029|M.avium_104 KDRVAAQLVAVSELVGDSAEIVPVSAVTGAQVDIVIDVLAAALPPGPAYY
MMAR_3674|M.marinum_M KDQVAAQLVAVSELVTNSAEIVPVSAVTGAQVEVLIDVLARTLPQGPAYY
MUL_3617|M.ulcerans_Agy99 KDQVAAQLVAVSELVTNSAEIVPVSAVTGAQVEVLIDVLARTLPQGPAYY
MLBr_00631|M.leprae_Br4923 KDRLSAQLVAVSDLVADSAEIVPVSAVTGEQVDVLIDVLAAALPPGPAYY
Mflv_2710|M.gilvum_PYR-GCK KDRVGEQLLAVSELFGPDADIVPVSATSGTQLDVLTDVLVSKLPPGPAFY
Mvan_3828|M.vanbaalenii_PYR-1 KDRVGEQLLAVSELFGPDADIVPVSATSGTQLDVLIDVLVSKLPPGPAFY
MSMEG_4493|M.smegmatis_MC2_155 KDRVAAQLLAVSELMGPDAEIVPVSATSGEQLDVLTNVLVSQLPPGPAYY
MAB_1672|M.abscessus_ATCC_1997 KERVAEQLLSVSQLVGKEVDIVPVSAVSGAQVEVLTEVLASKLQPGPAFY
TH_1204|M.thermoresistible__bu KHRVAEQLIAVSELVGPDVEIVPVSAVTGEQTDVLIEVLAAQLPPGPAFY
*.:: **::**:*. .:****** :* : ::: :**. * ***:*
Rv2364c|M.tuberculosis_H37Rv PDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGR---
Mb2385c|M.bovis_AF2122/97 PDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGR---
MAV_2029|M.avium_104 PDGELTDEPEEVLMAELIREAALEGVRDELPHSLAVVIDEVNPREDR---
MMAR_3674|M.marinum_M PDGELTDEPEEVLMAELIREAALEGVHDELPHSLAVVIDEVSPREGR---
MUL_3617|M.ulcerans_Agy99 PDGELTDEPEEVLMAELIREATLEGVHDELPHSLAVVIDEVSPREGR---
MLBr_00631|M.leprae_Br4923 SAGELTDEPEELLMAELIREAVLEGVHDELPHSLAVVIDEVSPRAGR---
Mflv_2710|M.gilvum_PYR-GCK PDGELTDEPEEVLMAELIREAALEGVRDELPHSLAVVIDEVEERPGRPED
Mvan_3828|M.vanbaalenii_PYR-1 PDGELTDEPEEVLMAELIREAALEGVRDELPHSLAVVIDEVEERPGRPDD
MSMEG_4493|M.smegmatis_MC2_155 PDGELTDEPEEVLMAELIREAALEGVRDELPHSLAVVIDEVSQREDR---
MAB_1672|M.abscessus_ATCC_1997 PDGELTDEPEEVLMAELIREAALEGVRDELPHSLAVVIDECSEREGRPEG
TH_1204|M.thermoresistible__bu PDGELTDEPEETLMAELIREAALEGVRDELPHSLAVVIDEVEKRPDR---
. ********* *********.*:**:************* . * .*
Rv2364c|M.tuberculosis_H37Rv DDLIDVHAALYVERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYL
Mb2385c|M.bovis_AF2122/97 DDLIDVHAALYVERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYL
MAV_2029|M.avium_104 DDLIDVHALLYVERDSQKGIIIGKGGARLREVGTAARAQIEKLLGTKVYL
MMAR_3674|M.marinum_M EDLIDVHAVLYVERDSQKGIIIGKGGARLREVGTAARSQIEKLLGTKIYL
MUL_3617|M.ulcerans_Agy99 EDLIDVHAVLYVERDSQKGIIIGKGGARLREVGTAARSQIEKLLGTKIYL
MLBr_00631|M.leprae_Br4923 GDLIDVHAVLYVERPSQKGIVIGKSGARLREVGIAARRQIEKLLGTNIYL
Mflv_2710|M.gilvum_PYR-GCK DPLIDVHAILYVERDSQKGIVIGKGGARLREVGTAARTQIEKLLGTRVYL
Mvan_3828|M.vanbaalenii_PYR-1 DPLIDVHAILYVERDSQKGIVIGKGGARLREVGTAARTQIEKLLGTKVYL
MSMEG_4493|M.smegmatis_MC2_155 DDLIDVHAILYVERDSQKGIVIGKGGARLREVGTAARKQIEKLLGTKVYL
MAB_1672|M.abscessus_ATCC_1997 SELIDVHAILYVERDSQKGIVIGKGGARLREVGTNARTQIEKLLGTKVFL
TH_1204|M.thermoresistible__bu DDLIDVHAILYVERDSQKGIVIGRGGSRLREVGTAARQQIEKLLGTKVFL
****** ***** *****:**:.*:****** ** ***:****.::*
Rv2364c|M.tuberculosis_H37Rv DLRVKVAKNWQRDPKQLGRLGF
Mb2385c|M.bovis_AF2122/97 DLRVKVAKNWQRDPKQLGRLGF
MAV_2029|M.avium_104 DLRVKVAKNWQSDPKQLGRLGF
MMAR_3674|M.marinum_M DLRVKVAKNWQRDPKQLGRLGF
MUL_3617|M.ulcerans_Agy99 DLRVKVAKNWQRDPKQLGRLGF
MLBr_00631|M.leprae_Br4923 DLHVNVAKNWQRNPKQLGRLGF
Mflv_2710|M.gilvum_PYR-GCK DLRVKIAKNWQRDPKQLGRLGF
Mvan_3828|M.vanbaalenii_PYR-1 DLRVKIAKNWQRDPKQLGRLGF
MSMEG_4493|M.smegmatis_MC2_155 DLRVKIAKNWQRDPKQLGKLGF
MAB_1672|M.abscessus_ATCC_1997 DLRVKVAKNWQRDPKQLGKLGF
TH_1204|M.thermoresistible__bu DLRVKVAKNWQRDPKQLGRLGF
**:*::***** :*****:***