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NAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIEALRNKDLEVDTSDLHIEIDAD KAARTLTVRDNGIGMAREEVVDLIGTLAKSGTAELRAQLREAKNAAASEELIGQFGIGFYSSFMVADKVQ LLTRKAGESAATRWESSGEGTYTIESVEDAPQGTSVTLHLKPEDAEDDLHDYTSEWKIRNLVKKYSDFIA WPIRMDVERRTPASQEEGGEGGEETVTIETETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEII AMKAEGTFEYQALLFIPSHAPFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKGVVDAQDMSLNV SREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRTFWTQFGRVLKEGLLSDIDNRETLLGISSFVS TYSEEEPTTLAEYVERMKDGQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVDEVWVGMVPEFD GKPLQSVAKGEVDLSSEEDTSEAEREERQKEFADLLTWLQETLSDHVKEVRLSTRLTESPACLITDAFGM TPALARIYRASGQEVPVGKRILELNPSHPLVTGLRQAHQDRADDAEKSLAETAELLYGTALLAEGGALED PARFAELLAERLARTL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2299c | htpG | - | 100% (647) | heat shock protein 90 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2321c | htpG | 0.0 | 100.00% (647) | heat shock protein 90 |
| M. gilvum PYR-GCK | Mflv_4650 | - | 0.0 | 82.03% (651) | heat shock protein 90 |
| M. leprae Br4923 | MLBr_01623 | htpG | 0.0 | 80.64% (656) | heat shock protein 90 |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3521 | htpG | 0.0 | 85.49% (648) | chaperone protein HtpG |
| M. avium 104 | MAV_2118 | - | 0.0 | 87.23% (650) | heat shock protein 90 |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2744 | htpG | 0.0 | 85.34% (648) | heat shock protein 90 |
| M. vanbaalenii PYR-1 | Mvan_1817 | - | 0.0 | 81.78% (653) | heat shock protein 90 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4650|M.gilvum_PYR-GCK MAPHVEQLEFQAEARQLLDLMIHSVYSNKDSFLRELISNASDALDKLRLE
Mvan_1817|M.vanbaalenii_PYR-1 MAAHVEQLEFQAEARQLLDLMIHSVYSNKDSFLRELVSNASDALDKLRLE
Rv2299c|M.tuberculosis_H37Rv MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIE
Mb2321c|M.bovis_AF2122/97 MNAHVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRIE
MMAR_3521|M.marinum_M MNARVEQLEFQAEARQLLDLMIHSVYSNKDSFLRELISNASDALDKLRIE
MUL_2744|M.ulcerans_Agy99 MNARVEQLEFQAEARQLLDLMIHSVYSNKDSFLRELISNASDALDKLRIE
MAV_2118|M.avium_104 MNARVEQLEFQAEARQLLDLMVHSVYSNKDSFLRELISNASDALDKLRLE
MLBr_01623|M.leprae_Br4923 MSAQVEQLEFQAEARQLLDLMVHSVYSNKDAFLRELISNASDALDKLRLE
* .:*****************:********:*****:***********:*
Mflv_4650|M.gilvum_PYR-GCK AFRNKDLD---VDTSDLHIEIVVDKEARTLTVRDNGIGMSRDEVVRLIGT
Mvan_1817|M.vanbaalenii_PYR-1 SFRNKDLD---VDTSDLHIEIDVDKEARTLTVRDNGIGMTRDEVVSLIGT
Rv2299c|M.tuberculosis_H37Rv ALRNKDLE---VDTSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGT
Mb2321c|M.bovis_AF2122/97 ALRNKDLE---VDTSDLHIEIDADKAARTLTVRDNGIGMAREEVVDLIGT
MMAR_3521|M.marinum_M AFRNKDLE---VDTSDLHIEIEADKGARTLTVRDNGIGMTRAEVVDLIGT
MUL_2744|M.ulcerans_Agy99 AFRNKDLE---VDTSDLHIETEADKGARTLTVRDNGIGMTRAEVVDLIGT
MAV_2118|M.avium_104 AFRNKDLD---VDTSDLHIQIEVDKDARTLTIRDNGIGMTRAEVVDLIGT
MLBr_01623|M.leprae_Br4923 AFRNKDLDPRTVDTSDLHIEIEVDKNTRILTVRDNGIGMTRAEVVDLIGT
::*****: ********: .** :* **:*******:* *** ****
Mflv_4650|M.gilvum_PYR-GCK LAKSGTAELRQQLREAK---DANANEELIGQFGIGFYASFMVADRVELLT
Mvan_1817|M.vanbaalenii_PYR-1 LAKSGTGELRQQLREAK---DKDTSEELIGQFGIGFYASFMVADRVELLT
Rv2299c|M.tuberculosis_H37Rv LAKSGTAELRAQLREAK---NAAASEELIGQFGIGFYSSFMVADKVQLLT
Mb2321c|M.bovis_AF2122/97 LAKSGTAELRAQLREAK---NAAASEELIGQFGIGFYSSFMVADKVQLLT
MMAR_3521|M.marinum_M LAKSGTAELRAQLREAK---NDAASEELIGQFGIGFYSSFMVADKVELLT
MUL_2744|M.ulcerans_Agy99 LAKSGTAELRAQLREAK---NDAASEELIGQFGIGFYSSFMVADKVELLT
MAV_2118|M.avium_104 LAKSGTAELRQQLREAKNAQNEAASEELIGQFGIGFYSSFMVADKVELLT
MLBr_01623|M.leprae_Br4923 LAKSGTAKLRQKLHAAKNLKDTAASEGLIGQFGIGFYSSFMVANKVELLT
******.:** :*: ** : :.* **********:*****::*:***
Mflv_4650|M.gilvum_PYR-GCK RKAGESEATRWESTGEGSYTIETVDQAGGEVPQGTSVTLHLKPEDREDEL
Mvan_1817|M.vanbaalenii_PYR-1 RKAGESEATRWESSGEGTYTIETVDQAGGEVPQGTSVTLHLKPEDREDEL
Rv2299c|M.tuberculosis_H37Rv RKAGESAATRWESSGEGTYTIESVEDA----PQGTSVTLHLKPEDAEDDL
Mb2321c|M.bovis_AF2122/97 RKAGESAATRWESSGEGTYTIESVEDA----PQGTSVTLHLKPEDAEDDL
MMAR_3521|M.marinum_M RKAGESEATKWESSGEGTYTIESVEGA----PQGTSVTLHLKPEDAEDEL
MUL_2744|M.ulcerans_Agy99 RKAGESEATKWESSGEGTYTIESVEGA----PQGTSVTLHLKPEDAEDEL
MAV_2118|M.avium_104 RKAGESEATKWESSGEGTYTIESVENA----PQGTSVTLHLKPEDTEDEL
MLBr_01623|M.leprae_Br4923 RKAGETAATRWSSDGEATYTIESVDEA----PQGTSVTLHLKPEDFEDEL
*****: **:*.* **.:****:*: * ************** **:*
Mflv_4650|M.gilvum_PYR-GCK HDYTSEWKIRELVKQYSDFIAWPVRMDVERRTPAS----EEGGEETVTVE
Mvan_1817|M.vanbaalenii_PYR-1 HDYTSEWKIRELVKQYSDFIAWPIRMEVERRTPAP----EDGGEESVTVE
Rv2299c|M.tuberculosis_H37Rv HDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIE
Mb2321c|M.bovis_AF2122/97 HDYTSEWKIRNLVKKYSDFIAWPIRMDVERRTPASQEEGGEGGEETVTIE
MMAR_3521|M.marinum_M YDYTADWKLRHLIKKYSDFIAWPIRMEVEKRVPAPHEEGEEPGEETVVLE
MUL_2744|M.ulcerans_Agy99 YDYTADWKLRHLIKKYSDFIAWPIRMEVEKRVPAPHEEGEEPGEETVVLE
MAV_2118|M.avium_104 HDYTSEFKIKSLVKKYSDFIAWPIRMEVERRTPAT----EEGGEETVTRE
MLBr_01623|M.leprae_Br4923 HDYTSEWKIRELVKKYSDFIAWPIRMEVERRAPATSDGEGADGEEQVTIE
:***:::*:: *:*:********:**:**:*.**. *** *. *
Mflv_4650|M.gilvum_PYR-GCK TQTLNSMKALWARPRDEVSDEEYTEFYKHVAHAWDEPLETIAMRAEGTFE
Mvan_1817|M.vanbaalenii_PYR-1 TETLNSMKALWARPRDEVSDEEYTEFYKHVAHAWDEPLEVIAMKAEGTFE
Rv2299c|M.tuberculosis_H37Rv TETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFE
Mb2321c|M.bovis_AF2122/97 TETLNSMKALWARPKEEVSEQEYKEFYKHVAHAWDDPLEIIAMKAEGTFE
MMAR_3521|M.marinum_M TETLNSMKALWARPKDEVSADEYNEFYKHIAHAWDDPMEVIAMKAEGTFE
MUL_2744|M.ulcerans_Agy99 TETLNSMKALWARPKDEVSADEYNEFYKHIAHAWDDPMEVIAMKAEGTFE
MAV_2118|M.avium_104 VETLNSMKALWARPKDEVSEEEYKEFYKHIAHAWDDPLEVIAMKAEGTFE
MLBr_01623|M.leprae_Br4923 TQTINSMKALWTKSKDEVSEDEYKEFYKHIAHAWDDPLEVIAMKAEGTFE
.:*:*******::.::*** :**.*****:*****:*:* ***:******
Mflv_4650|M.gilvum_PYR-GCK YQALLFIPSHAPFDLFQQNATVGVQLYVKRVFIMGDCDQLMPPYLRFVKG
Mvan_1817|M.vanbaalenii_PYR-1 YQALLFIPSHAPFDLFNQNAAVGVQLYVKRVFIMGDCDQLMPPYLRFVKG
Rv2299c|M.tuberculosis_H37Rv YQALLFIPSHAPFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKG
Mb2321c|M.bovis_AF2122/97 YQALLFIPSHAPFDLFDRDAHVGIQLYVKRVFIMGDCDQLMPEYLRFVKG
MMAR_3521|M.marinum_M YQALLFIPSHAQHDLFNRDAVFGIQLYVKRVFIMGDCDQLMPEYLRFVKG
MUL_2744|M.ulcerans_Agy99 YQALLFIPSHAQHDLFNRDAVFGIQLYVKRVFIMGDCDQLMPEYLRFVKG
MAV_2118|M.avium_104 YQALLFIPSHAPFDLFNRDAHTGIQLYVKRVFIMGDCDQLMPEYLRFVKG
MLBr_01623|M.leprae_Br4923 YQALLFIPSHAPFDLFNSDAKIGMQLYVKRVFIMSDCDQLMPMYLRFVKG
*********** .***: :* *:**********.******* *******
Mflv_4650|M.gilvum_PYR-GCK VVDAQDMSLNVSREILQQDRQIRAIRRRLTKKVLSTIAEMQAERPEKYRT
Mvan_1817|M.vanbaalenii_PYR-1 VVDAQDMSLNVSREILQQDRQIRAIRRRLTKKVLSTITEMQTERPEKYRT
Rv2299c|M.tuberculosis_H37Rv VVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRT
Mb2321c|M.bovis_AF2122/97 VVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDVQSSRPEDYRT
MMAR_3521|M.marinum_M VVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDLQSERPEDYRT
MUL_2744|M.ulcerans_Agy99 VVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKDLQSERPEDYRT
MAV_2118|M.avium_104 VVDAQDMSLNVSREILQQDRQIKAIRRRLTKKVLSTIKELQSERPDDYRT
MLBr_01623|M.leprae_Br4923 VVDAEDMSLNVSREILQQNRQINAIRRRLTKKVLSAIKDLQAERPQDYRT
****:*************:***.************:* ::*:.**:.***
Mflv_4650|M.gilvum_PYR-GCK FWTQFGRVLKEGLLSDTDNQETLLRVSSFASTRSDDEPTTLAEYVERMPE
Mvan_1817|M.vanbaalenii_PYR-1 FWTQFGRVLKEGLLTDIENQETLLRVCSFASTHSEDEPTTLAEYVERMPD
Rv2299c|M.tuberculosis_H37Rv FWTQFGRVLKEGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKD
Mb2321c|M.bovis_AF2122/97 FWTQFGRVLKEGLLSDIDNRETLLGISSFVSTYSEEEPTTLAEYVERMKD
MMAR_3521|M.marinum_M FWTQFGKVVKEGLLADFDNRETLLEISSFASTHSEEEPTTLAGYVERMKE
MUL_2744|M.ulcerans_Agy99 FWTQFGKVVKEGLLADFDNRETLLEISSFASTHSEEEPTTLAGYVERMKE
MAV_2118|M.avium_104 FWTQFGRVVKEGLLSDFDNQETLLQLCSFASTHSEEEATTLAQYVERMKE
MLBr_01623|M.leprae_Br4923 FWTQFGKVLKEGLMSDSDNRDTLLHISSFASTHSDEEPTTLAQYVERMKD
******:*:****::* :*::*** :.**.** *::*.**** ***** :
Mflv_4650|M.gilvum_PYR-GCK GQTQIFYAAGESRQQLLNSPHLEAFKAKGYEVLLLTDPVDEVWVESIHEF
Mvan_1817|M.vanbaalenii_PYR-1 GQSQIFYAAGESRQQLLHSPHLEAFKAKGYEVLLLTDPVDEVWVESVHEF
Rv2299c|M.tuberculosis_H37Rv GQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVDEVWVGMVPEF
Mb2321c|M.bovis_AF2122/97 GQQQIFYATGETRQQLLKSPHLEAFKAKGYEVLLLTDPVDEVWVGMVPEF
MMAR_3521|M.marinum_M GQTQIFFATGDSRQQILKSPHLEAFRAKGYEVLLLTEPVDEVWVGVVNEF
MUL_2744|M.ulcerans_Agy99 DQTQIFFATGDSRQQILKSPHLEAFRAKGYEVLLLTEPVDEVWVGVVNEF
MAV_2118|M.avium_104 GQTQIFYATGETRQQILKSPHLEAFKAKGYEVLLLTDPVDEVWVGTVTEF
MLBr_01623|M.leprae_Br4923 GQDQIFYATGESRQQVMNSPHLEAFKAKGYEVLLLTDPVDEVWVGMAPEF
.* ***:*:*::***:::*******:**********:******* **
Mflv_4650|M.gilvum_PYR-GCK DGKPLQSVAKGEVDLDSEADKEAQETERQQREKEFADVIAWLTEVLGDHV
Mvan_1817|M.vanbaalenii_PYR-1 DGKPLQSVAKGEVDLDSDADNDGQDAERQEREQGFADLIAWLKEALSDHV
Rv2299c|M.tuberculosis_H37Rv DGKPLQSVAKGEVDLSSEE--DTSEAEREERQKEFADLLTWLQETLSDHV
Mb2321c|M.bovis_AF2122/97 DGKPLQSVAKGEVDLSSEE--DTSEAEREERQKEFADLLTWLQETLSDHV
MMAR_3521|M.marinum_M DGKPLQSVAKGEVDLDSDG--EGSEAEREEQQKEFADLLGWLKETLGEQV
MUL_2744|M.ulcerans_Agy99 DGKPLQSVAKGEVDLDSDG--EGSEAEREEQQKEFADLLGWLKETLGEQV
MAV_2118|M.avium_104 DGKPLQSIAKGEVDLSAEG--EESQAEREEQQKEFADLLAWLKDTLSDHV
MLBr_01623|M.leprae_Br4923 DGKPLKSVARGEVDLESEEEKTAHEAERKEQEQNFAGLVNWLKETLSDHV
*****:*:*:*****.:: ::**::::: **.:: ** :.*.::*
Mflv_4650|M.gilvum_PYR-GCK KEVRLSTRLTDSPACLITDTFGITPALARMYRASGQPVPVEKRILELNPT
Mvan_1817|M.vanbaalenii_PYR-1 KEVRLSTRLTDSPACLITDTFGITPALARMYRASGQPVPVEKRILELNPN
Rv2299c|M.tuberculosis_H37Rv KEVRLSTRLTESPACLITDAFGMTPALARIYRASGQEVPVGKRILELNPS
Mb2321c|M.bovis_AF2122/97 KEVRLSTRLTESPACLITDAFGMTPALARIYRASGQEVPVGKRILELNPS
MMAR_3521|M.marinum_M KEVRLSTRLTDSPACLITDTFGITPALARIYRATGQDVPVGKRTLELNPT
MUL_2744|M.ulcerans_Agy99 KEVRLSTRLTESPACLITDTFGITPALARIYRATGQDVPVGKRTLELNPT
MAV_2118|M.avium_104 KEVRLSNRLTDSPACLITDAFGITPALARLYRASGQDIPVGKRILELNPK
MLBr_01623|M.leprae_Br4923 KEVRLSTRLTESPACLITDAFGITPALARIYRASGQDVPFGKRILELNPN
******.***:********:**:******:***:** :*. ** *****.
Mflv_4650|M.gilvum_PYR-GCK HPLVVGLREAHESRGADD---ELAGTAELLYGTALLAEGGALEDPARFAG
Mvan_1817|M.vanbaalenii_PYR-1 HPLITGLREAHKSRGADA---ELVGTAELLYGTALLAEGGVLEDPARFAG
Rv2299c|M.tuberculosis_H37Rv HPLVTGLRQAHQDRADDAEK-SLAETAELLYGTALLAEGGALEDPARFAE
Mb2321c|M.bovis_AF2122/97 HPLVTGLRQAHQDRADDAEK-SLAETAELLYGTALLAEGGALEDPARFAE
MMAR_3521|M.marinum_M HPLVIGLRQAQASADDDAKKAAVSETAELLYGTALLAEGGAPDDPARFAE
MUL_2744|M.ulcerans_Agy99 HPLVIGLRQAQASADDDAKKEAVSETAELLYGTALLAEGGAPDDPARFAE
MAV_2118|M.avium_104 HPLVTGLRQAHQDRADDP---SVAETAELLYGTALLAEGGALDDPARFAE
MLBr_01623|M.leprae_Br4923 HPLITGLQQAHENGGDDTHLRQLSETAELLYGTALLTEGGALENPAKFAG
***: **::*: . * : ***********:***. ::**:**
Mflv_4650|M.gilvum_PYR-GCK LLADRLTRMVGEQS
Mvan_1817|M.vanbaalenii_PYR-1 LLADRLTRTVGDQT
Rv2299c|M.tuberculosis_H37Rv LLAERLARTL----
Mb2321c|M.bovis_AF2122/97 LLAERLARTL----
MMAR_3521|M.marinum_M LLADRLTRTL----
MUL_2744|M.ulcerans_Agy99 LLADRLTRTL----
MAV_2118|M.avium_104 ILADRLARTL----
MLBr_01623|M.leprae_Br4923 LLADLLSRSM----
:**: *:* :