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MPVEAPRPARHLEVERKFDVIESTVSPSFEGIAAVVRVEQSPTQQLDAVYFDTPSHDLARNQITLRRRTG GADAGWHLKLPAGPDKRTEMRAPLSASGDAVPAELLDVVLAIVRDQPVQPVARISTHRESQILYGAGGDA LAEFCNDDVTAWSAGAFHAAGAADNGPAEQQWREWELELVTTDGTADTKLLDRLANRLLDAGAAPAGHGS KLARVLGATSPGELPNGPQPPADPVHRAVSEQVEQLLLWDRAVRADAYDAVHQMRVTTRKIRSLLTDSQE SFGLKESAWVIDELRELADVLGVARDAEVLGDRYQRELDALAPELVRGRVRERLVDGARRRYQTGLRRSL IALRSQRYFRLLDALDALVSERAHATSGEESAPVTIDAAYRRVRKAAKAAKTAGDQAGDHHRDEALHLIR KRAKRLRYTAAATGADNVSQEAKVIQTLLGDHQDSVVSREHLIQQAIAANTAGEDTFTYGLLYQQEADLA ERCREQLEAALRKLDKAVRKARD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2226 | - | - | 100% (513) | hypothetical protein Rv2226 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2250 | - | 0.0 | 99.61% (513) | hypothetical protein Mb2250 |
| M. gilvum PYR-GCK | Mflv_2900 | - | 1e-165 | 60.38% (525) | CHAD domain-containing protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1914c | - | 1e-151 | 58.53% (504) | adenylate cyclase |
| M. marinum M | MMAR_3301 | - | 0.0 | 67.97% (537) | hypothetical protein MMAR_3301 |
| M. avium 104 | MAV_2235 | - | 0.0 | 66.79% (548) | adenylate cyclase, putative |
| M. smegmatis MC2 155 | MSMEG_4302 | - | 1e-163 | 59.46% (518) | adenylate cyclase, putative |
| M. thermoresistible (build 8) | TH_1469 | - | 1e-39 | 69.35% (124) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1328 | - | 0.0 | 67.60% (537) | hypothetical protein MUL_1328 |
| M. vanbaalenii PYR-1 | Mvan_3605 | - | 1e-172 | 63.23% (514) | CHAD domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2226|M.tuberculosis_H37Rv ---------------MPVEAPRPARHLEVERKFDVIESTVSPSFEGIAAV
Mb2250|M.bovis_AF2122/97 ---------------MPVEAPRPARHLEVERKFDVIESTVSPSFEDIAAV
MMAR_3301|M.marinum_M ---------------MPVKAPKTARHLEVERKFDVVESTVSPSFEGIAAV
MUL_1328|M.ulcerans_Agy99 ---------------MPVKAPKTARHLEVECKFDVVESTVSPSFEGIAAV
MAV_2235|M.avium_104 ---------------MPAQAPQTSRHLEVERKFDVVESTVMPSFEGIAAV
MAB_1914c|M.abscessus_ATCC_199 ---------------------MPSQHVEVERKFDVTDATISPSFEGISVV
MSMEG_4302|M.smegmatis_MC2_155 ---------------MVPIKPKTARYTEVERKFEVTAATVSPSFEGLSAI
Mflv_2900|M.gilvum_PYR-GCK ---------------MAAKSPETSRYTETERKFEVVDSTVSPSFEGLSAV
Mvan_3605|M.vanbaalenii_PYR-1 MARYGPRNHGRDRVTMAANSPETSRHTETERKFEVVEATVSPSFDGLSAV
TH_1469|M.thermoresistible__bu --------------------------------------------------
Rv2226|M.tuberculosis_H37Rv VRVEQSPTQQLDAVYFDTPSHDLARNQITLRRRTGGADAGWHLKLPAGPD
Mb2250|M.bovis_AF2122/97 VRVEQSPTQQLDAVYFDTPSHDLARNQITLRRRTGGADAGWHLKLPAGPD
MMAR_3301|M.marinum_M ARVERKPVQALDAVYFDTADQDLASNRITLRRRTGGSDAGWHLKLPAGGD
MUL_1328|M.ulcerans_Agy99 ARVERKPVQALDAVYFDTADQDLASNRITLRRRTGGSDAGWHLKLPAGGD
MAV_2235|M.avium_104 ARVEQSPTQILDATYFDTPAHDLARNKITLRRRTGGSDAGWHLKLPAGPD
MAB_1914c|M.abscessus_ATCC_199 ARVEQQPQQNLDAVYFDTPGQRLAQHHITLRRRTGGTDAGWHLKLPAGPD
MSMEG_4302|M.smegmatis_MC2_155 ARIERIPSQELDAVYFDTSTRALAARRVTLRRRTGGTDAGWHLKLPAGPD
Mflv_2900|M.gilvum_PYR-GCK ARVERSPSQSLAAVYFDTPGRDLARHKITLRRRTGGTDAAWHLKLPAGAE
Mvan_3605|M.vanbaalenii_PYR-1 GRVQRLTSQSLDAVYFDTPGRDLARHRITLRRRTGGTDAGWHLKLPAGAD
TH_1469|M.thermoresistible__bu --------------------------------------------------
Rv2226|M.tuberculosis_H37Rv KRTEMRAPLSASG----------DAVPAELLDVVLAIVRDQPVQPVARIS
Mb2250|M.bovis_AF2122/97 KRTEMRAPLSASG----------DAVPAELLDVVLAIVRDQPVQPVARIS
MMAR_3301|M.marinum_M ARTELHAPITEPDTSESLGAPTQHRVPAELLDVVLAIVRDRPLQPVARIS
MUL_1328|M.ulcerans_Agy99 ARTELHAPITEPDTSGSLGAPTQHRVPAELLDVVLAIVRDRPLQPVARIN
MAV_2235|M.avium_104 ARTEVRAPLDASD---------ADTVPTELVDVVLAIVRNRPLRPVARIT
MAB_1914c|M.abscessus_ATCC_199 TRTELRLPLTEDD----------DAVPEELRDTVLAVVREDELAPVARIS
MSMEG_4302|M.smegmatis_MC2_155 ARTEVRAPLDNAT----------DGVPDDLRDIVLGIVRERPLEPVARIT
Mflv_2900|M.gilvum_PYR-GCK TRTEIHVPLGDDEP------ADDPTVPESLRDVVAAIVRDRPLAPVARIN
Mvan_3605|M.vanbaalenii_PYR-1 SRTEVHAPLSDDGD------AAHPTVPESLRDIVLAIVRDRPLAPVARIS
TH_1469|M.thermoresistible__bu --------------------------------------------------
Rv2226|M.tuberculosis_H37Rv THRESQILYGAGGDALAEFCNDDVTAWS-----AGAFHAAGAADNG----
Mb2250|M.bovis_AF2122/97 THRESQILYGAGGDALAEFCNDDVTAWS-----AGAFHAAGAADNG----
MMAR_3301|M.marinum_M TQRASQFLYGVDGAPLAEFCDDHVTAWS-----AGAG-----PDAE----
MUL_1328|M.ulcerans_Agy99 TQRASQFLYGVDGAPLAEFCDDHVTAWS-----AGAG-----PDAE----
MAV_2235|M.avium_104 TERDTQVLYDAAGQPLAEFSNDHVTAWATPSAPEGPDDGSGGVDEGSGGF
MAB_1914c|M.abscessus_ATCC_199 TVRLVSRLIGADGEELAEFCDDHVTAGD----------------------
MSMEG_4302|M.smegmatis_MC2_155 THRTVSVLYAHNGAVLAEFCDDHVTASATG--------------------
Mflv_2900|M.gilvum_PYR-GCK TTRVVEKLYGPGGVGIAEFCDDHVTAGAVG--------------------
Mvan_3605|M.vanbaalenii_PYR-1 TLRNVDVLYGPDGSAVAEFCDDQVTASAVG--------------------
TH_1469|M.thermoresistible__bu --LSGNVFVQPEG--LQTFSQTHSGIAG----------------------
. : * : *.: .
Rv2226|M.tuberculosis_H37Rv ---------------------PAEQQWREWELELV----TTDGTADTKLL
Mb2250|M.bovis_AF2122/97 ---------------------PAEQQWREWELELV----TTDGTADTKLL
MMAR_3301|M.marinum_M ---------------------PAQQQWREWELELS----DPSQSASRELL
MUL_1328|M.ulcerans_Agy99 ---------------------PAQQQWREWELELS----DPSQSASRELL
MAV_2235|M.avium_104 DDTAASPTDQAPTQNPPTRHPPTQQEWREWELELLGGNGHAEGAAGAELL
MAB_1914c|M.abscessus_ATCC_199 ------------------------LSWREWELELS-------GGPDIALF
MSMEG_4302|M.smegmatis_MC2_155 -------------------HEDHAQQWREWELELA-------PGADAELL
Mflv_2900|M.gilvum_PYR-GCK ---------------------GDELTWREWELELQ-------PGGDTDVF
Mvan_3605|M.vanbaalenii_PYR-1 ---------------------GDEQHWREWELELG-------PGTGSEVF
TH_1469|M.thermoresistible__bu ------------------------------ALPQS---------------
*
Rv2226|M.tuberculosis_H37Rv DRLANRLLDAGAAPAGHGSKLARVLGATSPG-ELPN---GPQPPADPVHR
Mb2250|M.bovis_AF2122/97 DRLANRLLDAGAAPAGHGSKLARVLGATSPG-ELPN---GPQPPADPVHR
MMAR_3301|M.marinum_M DRLSNRLLDTGAAPAGHGSKLARVLGSTSP----SA---GRPEPADPVHR
MUL_1328|M.ulcerans_Agy99 DRLSNRLLDTGAAPAGHDSKLARVLGSTSP----WA---GRPEPADPVHR
MAV_2235|M.avium_104 NRLSNRLLDAGAVPAGHGSKLARVLGRAPS----PN---GARPPEDPLQR
MAB_1914c|M.abscessus_ATCC_199 DRITARLLDAGAVPAGHGSKLARVLDVPER---------ERPKGKDSIQR
MSMEG_4302|M.smegmatis_MC2_155 DRLTNRLLDAGAQPAGHGSKLARALASAPGAPSDTP---EPAQPTDALHR
Mflv_2900|M.gilvum_PYR-GCK DRLTNRLLDAGARAAGHGSKLARVLASAPDAGDSVPGESTGAEADDPARR
Mvan_3605|M.vanbaalenii_PYR-1 DRLTNRLLDAGARPAGHGSKLARVLESS---APEVEDTEAVAAPTDPARR
TH_1469|M.thermoresistible__bu --------SAEATPG----------------------------PVETSHG
.: * .. :. :
Rv2226|M.tuberculosis_H37Rv AVSEQVEQLLLWDRAVRADAYDAVHQMRVTTRKIRSLLTDSQESFGLKES
Mb2250|M.bovis_AF2122/97 AVSEQVEQLLLWDRAVRADAYDAVHQMRVTTRKIRSLLTDSQESFGLKES
MMAR_3301|M.marinum_M AVARYVAELLVWDRAVRADVDDSVHQMRVTTRKIRSLLADSQDSFGLADK
MUL_1328|M.ulcerans_Agy99 AVARYVAELLVWDRAVRTDVDDSVHQMRVTTRKIRSLLADSQDSFGLADK
MAV_2235|M.avium_104 AIAEQVRELLVWDRAVRADAFDSVHQMRVTTRKLRSLLRDYQDSFGLGDD
MAB_1914c|M.abscessus_ATCC_199 ALLEQLDQLQGWDRAVRVDTDDSVHQMRVTIRRIRSLLQSNPERFGLDTN
MSMEG_4302|M.smegmatis_MC2_155 AIAEHLDELLVWDRAVRADAEDSVHQMRVTTRKIRSLLKESGDAFG--DV
Mflv_2900|M.gilvum_PYR-GCK AVAQHIAELVEWDRAVRADEWDSVHQMRVTTRKIRSLLQSSEGSFDIADH
Mvan_3605|M.vanbaalenii_PYR-1 AVAVHLEELIEWDRAVRADAWDSVHQMRVTTRKIRSLLQSSEGSFDIADH
TH_1469|M.thermoresistible__bu PIAAAANAALRNALSSRG---GTVQATTTSAATISELLHR----------
.: : * .:*: .: : .**
Rv2226|M.tuberculosis_H37Rv AWVIDELRELADVLGVARDAEVLGDRYQRELDALAPELVRGRVRERLVDG
Mb2250|M.bovis_AF2122/97 AWVIDELRELANVLGVARDAEVLGDRYQRELDALAPELVRGRVRERLVDG
MMAR_3301|M.marinum_M AWVLDELRELAAVLGVARDAEVLGQRYQHALERLDPTLVRGPVYERLVDG
MUL_1328|M.ulcerans_Agy99 AWVLDELRELAAVLGVARDAEVLGQRYQHALERLDPTLVRGPVYERLVDG
MAV_2235|M.avium_104 AWVLDELRELAGILGVARDAEVLAERYERDLGALPPELVRGPVRERLVGG
MAB_1914c|M.abscessus_ATCC_199 PEPLDELRLLANILGVARDAEVLAQRYDEALAELPDTLIRGPVYERLVDA
MSMEG_4302|M.smegmatis_MC2_155 GPILDELRELGTVLGVARDAEVLAERYEHALADLPDELVRGPVAERLVGG
Mflv_2900|M.gilvum_PYR-GCK EWILDELRELAAVLGIARDAEVLAERYERALDALPEVNVRGPVRERLVEG
Mvan_3605|M.vanbaalenii_PYR-1 EWVLDELRELAAVLGVARDAEVLAERYQRAIDKLPEANVRGPVRERLVDG
TH_1469|M.thermoresistible__bu --------------------------------------------------
Rv2226|M.tuberculosis_H37Rv ARRRYQTGLRRSLIALRSQRYFRLLDALDALVSER--AHATSGEESAP-V
Mb2250|M.bovis_AF2122/97 ARRRYQTGLRRSLIALRSQRYFRLLDALDALVSER--AHATSGEESAP-V
MMAR_3301|M.marinum_M ARHRYHAGLRRSLVAMRSKRYFRLLDALDAIAAAYPADTAAAGAEPAPPP
MUL_1328|M.ulcerans_Agy99 ARHRYHAGLRRSLVAMRSKRYFRLLDALDAIAAAYPADTAAAGAEPAPPP
MAV_2235|M.avium_104 ARRRYQVGLRRSLIAMRSQRYFRLLDSLDAIAARR---PGLPGAEEQAPV
MAB_1914c|M.abscessus_ATCC_199 ARQRYEAGLRRALAAMRSHRYFRLLDSLDELVASAG--PASDTHHSDEGG
MSMEG_4302|M.smegmatis_MC2_155 ARQRYESGLRRIHLAMRSQRYFRLLDALEGLVASS-----TDTDTGDPAA
Mflv_2900|M.gilvum_PYR-GCK AKKRYQTGWKRSLTAMRSQRYFRLLDALDELVASDP--PESAAGEEPPQL
Mvan_3605|M.vanbaalenii_PYR-1 AEKRYQTGWKRSLTAMRSQRYFRLLDALEELIATEP--VASGRGETPAEL
TH_1469|M.thermoresistible__bu AARAYQEGDLRSAEELR--------AAANAIADGTG----AGGX------
* : *. * * :* : : :
Rv2226|M.tuberculosis_H37Rv TIDAAYRRVRKAAKAAKTAGDQ-----------AGDHHR-DEALHLIRKR
Mb2250|M.bovis_AF2122/97 TIDAAYRRVRKAAKAAKTAGDQ-----------AGDHHR-DEALHLIRKR
MMAR_3301|M.marinum_M SIEAAYRRVRKAAKLAKAAAKAPSSPAESAAVDAGAHLGPNEALHRIRKR
MUL_1328|M.ulcerans_Agy99 SIEAAYRRVRKAAKLAKAAAKAPSSPAESAAVDAGAHLGPNEALHRIRKR
MAV_2235|M.avium_104 TIDTAYRKVRKAAKAAARVDREH----------PGDRHLRDEAIHRIRKR
MAB_1914c|M.abscessus_ATCC_199 TLDAAYRKVRRAARAAARAEGEYR----------------DEALHRIRKS
MSMEG_4302|M.smegmatis_MC2_155 TVAAAYKRVRKAVKKAQHTDHTTDPDAGTDAG-TDAVAARNHALHRIRKR
Mflv_2900|M.gilvum_PYR-GCK NIGSAYKRVRKAAKAARAAAGDAETG----------TDESNEALHRIRKR
Mvan_3605|M.vanbaalenii_PYR-1 TIDSAYKRVRKAAKAARAAAADAKT-------------ESDEALHRIRKR
TH_1469|M.thermoresistible__bu --XXAHERVRKAAKAADRAAGDD---------------ERDEALHRIRKG
*:.:**:*.: * . :.*:* ***
Rv2226|M.tuberculosis_H37Rv AKRLRYTAAATGADNVSQEAKVIQTLLGDHQDSVVSREHLIQQAIAANTA
Mb2250|M.bovis_AF2122/97 AKRLRYTAAATGADNVSQEAKVIQTLLGDHQDSVVSREHLIQQAIAANTA
MMAR_3301|M.marinum_M AKRLRYTAAATGAVQVSSQAKAIQTLLGDHQDSVVSREHLLHETDAAHAA
MUL_1328|M.ulcerans_Agy99 AKRLRYTAAATGAVQVSSQAKAIQTLLGDHQDSVVSREHLLHETDAAHAA
MAV_2235|M.avium_104 AKRLRYTATATGAARVAERAKAVQSLLGDHQDSVVSREHLSQEAQAAHAA
MAB_1914c|M.abscessus_ATCC_199 AKRLRYVASAEGAKKISQAAKDIQELLGEHQDSTVSRAYLATQAAEAHSA
MSMEG_4302|M.smegmatis_MC2_155 AKQLRYTASAAGEDRIAERAKAVQSLLGDHQDAVVSMAHLLDQADAAHAA
Mflv_2900|M.gilvum_PYR-GCK AKALRYTAAATAASKVADRAKAIQSLLGDHQDSVVSRTHLSRQAEVAHAA
Mvan_3605|M.vanbaalenii_PYR-1 AKQLRYTAAAIGENKVAERAKVIQSLLGDHQDSVVSRAHLSRQAQVAHAA
TH_1469|M.thermoresistible__bu AKRLRYLAAAAGAAEVADRAEAVQTLLGEHQDSVVSRAHLIAQADAAHAA
** *** *:* . .::. *: :* ***:***:.** :* :: *::*
Rv2226|M.tuberculosis_H37Rv GEDTFTYGLLYQQEADLAERCREQLEAALRKLDKAVRKARD--
Mb2250|M.bovis_AF2122/97 GEDTFTYGLLYQQEADLAERCREQLEAALRKLDKAVRKARD--
MMAR_3301|M.marinum_M GQDTFTYGLLYQRESDLAEGCRQRLDAALHRLDKSVRKTRR--
MUL_1328|M.ulcerans_Agy99 GQDTFTYGLLYQRESDLAEGCRQRLDAALHRLDKSVRKTRR--
MAV_2235|M.avium_104 GEDTFTYGLLYQREADLAQRCRDELDDTLRKLGKAVHKAD---
MAB_1914c|M.abscessus_ATCC_199 GEDTFTYGVLYQREHDAAETARHQVEATLKALRKAVRHKK---
MSMEG_4302|M.smegmatis_MC2_155 GEDTFTYGLLYQQEDELAWQARTQLQKVLKKLKRAVRKDL---
Mflv_2900|M.gilvum_PYR-GCK GEDTFTYGLLYQLEDDLARRCEEQIDDALKALDKAVAKSR---
Mvan_3605|M.vanbaalenii_PYR-1 GEDTFTYGLLYQQEDDLALRCEEQIEDALRQLDKSVGRR----
TH_1469|M.thermoresistible__bu GADTFTYGLLYQQEVALAQRCRAQLDPALKKLRKAVRRYRKRG
* ******:*** * * .. .:: .*: * ::* :