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TRVLLLGGTAEGRALAKELHPHVEIVSSLAGRVPNPALPIGPVRIGGFGGVEGLRGWLREERIDAVVDAT HPFAVTITAHAAQVCGELGLPYLVLARPPWDPGTAIIAVSDIEAADVVAEQGYSRVFLTTGRSGIAAFAN SDAWFLIRVVTAPDGTALPRRHKLVLSRGPYGYHDEFALLREQRIDALVTKNSGGKMTRAKLDAAAALGI SVVMIARPLLPAGVAAVDSVHRAAMWVAGLPSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2070c | cobK | - | 100% (244) | cobalt-precorrin-6x reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2096c | cobK | 1e-126 | 98.68% (227) | cobalt-precorrin-6x reductase |
| M. gilvum PYR-GCK | Mflv_0359 | - | 1e-44 | 47.30% (241) | precorrin-6x reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2197 | - | 5e-75 | 59.40% (234) | cobalt-precorrin-6x reductase |
| M. marinum M | MMAR_3052 | cobK | 1e-104 | 76.15% (239) | precorrin-6x reductase, CobK |
| M. avium 104 | MAV_2427 | cobK | 1e-103 | 76.15% (239) | cobalt-precorrin-6x reductase |
| M. smegmatis MC2 155 | MSMEG_3875 | cobK | 2e-94 | 69.83% (242) | cobalt-precorrin-6x reductase |
| M. thermoresistible (build 8) | TH_0442 | cobK | 3e-83 | 63.18% (239) | Probable precorrin-6X reductase CobK |
| M. ulcerans Agy99 | MUL_2296 | cobK | 1e-103 | 75.10% (241) | cobalt-precorrin-6x reductase |
| M. vanbaalenii PYR-1 | Mvan_0378 | - | 4e-48 | 49.39% (245) | precorrin-6x reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2070c|M.tuberculosis_H37Rv -----MTRVLLLGGTAEGRALAKELH---PHVEIVSSLAGRVPNPALPIG
Mb2096c|M.bovis_AF2122/97 ------------------MRWRKSCN---PHVEIVSSLAGRVPNPALPIG
MMAR_3052|M.marinum_M -----MTRLLLLGGTSEGRALAARLH---PQVDLVSSLAGRVPDPALPVG
MUL_2296|M.ulcerans_Agy99 -----MTRLLLLGGTSEGRALAARLH---PQVDLVSSLAGRVPDPALPVG
MAV_2427|M.avium_104 ------MRLLLLGGTGEARALAKALH---PRIDIISSLAGRVPDPALPVG
MSMEG_3875|M.smegmatis_MC2_155 MTETATMRVLLLGGTGEARALAAALHPLQPEIEVISSLAGRVPDPALPVG
TH_0442|M.thermoresistible__bu ------MRILLLGGTGEARALAARLH---PDVGVISSLAGRVPDPALPVG
MAB_2197|M.abscessus_ATCC_1997 ---------MILGGSAEARELAERLA---PRFDVTTSLAGRVNNPAVPAG
Mflv_0359|M.gilvum_PYR-GCK ------MRVLILGGTAEARALAELLT--ADGVEVMSSLAGRVADPRLPVG
Mvan_0378|M.vanbaalenii_PYR-1 ------MRIMLLGGTSEARALAELLT--AESVEVTTSLAGRVNDPRLPVG
. : :****** :* :* *
Rv2070c|M.tuberculosis_H37Rv PVRIGGFGGVEGLRGWLREERIDAVVDATHPFAVTITAHAAQVCGELGLP
Mb2096c|M.bovis_AF2122/97 PVRIGGFGGVEGLRGWLREERIDAVVDATHPFAVTITAHAAQVCGELGLP
MMAR_3052|M.marinum_M PVRIGGFGGVDGLRRWLVDERIDAVVDATHPFAATMTAHAAQVCAELALP
MUL_2296|M.ulcerans_Agy99 PVRIGRFGGVDGLRRWLVDERIDAVVDATHPFAATMTAHAAQVCAELALP
MAV_2427|M.avium_104 PVRIGGFGGVDGLRRWLRDEHIDAVVDATHPFASTMTAHAAQACAELGVP
MSMEG_3875|M.smegmatis_MC2_155 QVRIGGFGGVEGMRRWLRDEGIDAVVDATHPFAETITTHAAQVCAELGLP
TH_0442|M.thermoresistible__bu DVRIGGFGGPQGLRRWLSENPVDAVIDATHPFAATMTATAAQVCADTGVP
MAB_2197|M.abscessus_ATCC_1997 ALRIGGFGGEVGLRKWLLDNAIDAVVDATHPFAATITENAAAACARLGIP
Mflv_0359|M.gilvum_PYR-GCK DVRIGGFGGVDGLAATARD--YTAVVDATHPFAQHISANAVAACTSAHTP
Mvan_0378|M.vanbaalenii_PYR-1 EVRIGGFGGVDGLRAALSG--YDAVVDATHPFARNISANAAAAAG--DTP
:*** *** *: **:******* :: *. .. *
Rv2070c|M.tuberculosis_H37Rv YLVLARPPWD--PGTAIIAVSDIEAADVVAEQGYSRVFLTTGRSGIAAFA
Mb2096c|M.bovis_AF2122/97 YLVLARPPWD--PGTAIIAVSDIEAADVVAEQGYSRVFLTTGRSGIAAFA
MMAR_3052|M.marinum_M HIVLARPPWD--PGAALVVRSDIEAAESVAQQRFSRIFLTTGRSGTAAFI
MUL_2296|M.ulcerans_Agy99 HIVLARPPWD--PGAALVVRSDIEAVESVAQQRFSRIFLTTGRSGTAAFI
MAV_2427|M.avium_104 HLVLARPAWD--PGAATVVDSDTRAAETVAEQGYSRVFLTTGRSGARAFK
MSMEG_3875|M.smegmatis_MC2_155 HLVLARPAWS--PGDAIVVASDTEAAEVVAQRGFSRVFLTTGRSGTSAFR
TH_0442|M.thermoresistible__bu HLVLVRPAWP--TDGAIVVRSDRDAARAVREHRFTRVFVTSGRSSLPAFT
MAB_2197|M.abscessus_ATCC_1997 HLIVRRPPWP--AGDATVVSSAAEAKDAVVAQGFSRVFLTSGRSSVGAFL
Mflv_0359|M.gilvum_PYR-GCK LLRLERPGWSGRSQESWHWVDSHEDAAATAARLGGRPFLTVGRQEMHRFV
Mvan_0378|M.vanbaalenii_PYR-1 LLRLERPGWADRSRDSWHWVDTHEEAAAAAAQLGRRPFLTVGRQEIARFI
: : ** * . : . . : * *:* **. *
Rv2070c|M.tuberculosis_H37Rv --NSDAWFLIRVVTAPDGTALPRRHKLVLSRGPYGYHDEFALLREQRIDA
Mb2096c|M.bovis_AF2122/97 --NSDAWFLIRVVTAPDGTALPRRHKLVLSRGPYGYHDEFALLREQRIDA
MMAR_3052|M.marinum_M --DSDAWFLIRAVTAPDGASLPRRHQLVLSRGPYHYDDEVRLLREHRIDA
MUL_2296|M.ulcerans_Agy99 --DSDAWFLIRAVTAPDGASLPRRHQLVLSRGPYHYDDEVRLLREHRIDA
MAV_2427|M.avium_104 --DSDAWFLIRAVTEPDATTLPRRHRVVLSRGPYRYDDELAMLGEHRIDA
MSMEG_3875|M.smegmatis_MC2_155 --GVDAWFLIRAVTEPDAGTLPARHELLLSRGPYDYEGELALLRDHRIDA
TH_0442|M.thermoresistible__bu --DVDAWFLIRVVTPPEQRVLPRRHELLLSRGPYHLEGERNLLRHHRIDA
MAB_2197|M.abscessus_ATCC_1997 --FSDAWFLIRVVEPMSADELPERHHLLLSRGPYTVAEETELMRQYEIEV
Mflv_0359|M.gilvum_PYR-GCK PDLGDHAVLARVVQAP-EFPLPSAWRLLTSRGPYELAGELALMRNHRTDV
Mvan_0378|M.vanbaalenii_PYR-1 PDLRDRAVLARVVQAP-DVALPPTWRLLTSRGPYELPGELHLMREHRADV
* .* *.* ** .:: ***** * :: . . :.
Rv2070c|M.tuberculosis_H37Rv LVTKNSGGKMTRAKLDAAAALGISVVMIARPLLPAGVAAVDSVHRAAMWV
Mb2096c|M.bovis_AF2122/97 LVTKNSGGKMTRAKLDAAAALGISVVMIARPLLPAGVAAVDSVHRAAMWV
MMAR_3052|M.marinum_M LVTKNSGGAMTRAKLDAAGALDVPVVMVARPRLPAGVSSVGTVEEAAAWV
MUL_2296|M.ulcerans_Agy99 LVTKNSGGAMTRAKLDAAGALDVPVVMVARPRLPAGVSSVGTVEEAAAWV
MAV_2427|M.avium_104 LVTKNSGGQMTRAKLDAAAALDIPVVMVARPALPAGVSAVGSVAEAAEWV
MSMEG_3875|M.smegmatis_MC2_155 LVTKNSGGDMTQPKLDAAATAGVAVIMVDRPPLPAGVHSVTTVEQARDWV
TH_0442|M.thermoresistible__bu LVTKNSGGRMTRAKLDAAAELNIPVIMVDRPALPPGVTTVSTVAEAVDWV
MAB_2197|M.abscessus_ATCC_1997 LVTKNSGGTMTSAKLEAAAALGIPVVMIDRPALPENVSTVSTVDAAQQWV
Mflv_0359|M.gilvum_PYR-GCK LITKDSGGQHTWPKMEAAVTLGVPVVVVRRPPRSQAVPTVHEVADAAEWV
Mvan_0378|M.vanbaalenii_PYR-1 LITKDSGGQHTWPKMEAAAQLDVPVVVVRRPARAAGVPTVHDATEAVAWV
*:**:*** * .*::** .:.*::: ** . * :* . * **
Rv2070c|M.tuberculosis_H37Rv AGLPSR--
Mb2096c|M.bovis_AF2122/97 AGLPSR--
MMAR_3052|M.marinum_M ALLR----
MUL_2296|M.ulcerans_Agy99 ARLR----
MAV_2427|M.avium_104 AALAIKD-
MSMEG_3875|M.smegmatis_MC2_155 SSLRR---
TH_0442|M.thermoresistible__bu SSLRG---
MAB_2197|M.abscessus_ATCC_1997 TERDNAGV
Mflv_0359|M.gilvum_PYR-GCK RRQTV---
Mvan_0378|M.vanbaalenii_PYR-1 RNLPGASR