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PEPTVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDLLAEASIVVIRILGGYRAWQSGIDTVIAGG VPAVLVSGEQAADAELTDRSTVAAGTALQAHIYLAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWG VLERPDAGKTGPTIAVLYYRAQHLAGNTGYVEALCRAIEDAGGRPLPLYCASLRTAEPRLLERLGGADAM VVTVLAAGGVKPAAASAGGDDDSWNVEHLAALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQVAVPEF DGRIITVPFSFKEIDDDGLISYVADPERCARVAGLAVRHARLRQVAPADKRVALVFSAYPTKHARIGNAV GLDTPASAVALLQAMRQRGYRVGDLPGVESNDGDALIHALIECGGHDPDWLTEGQLAGNPIRVSAKEYRD WFATLPAELTDVVTAYWGPPPGELFVDRSHDPDGEIVIAALRAGNLVLMVQPPRGFGENPVAIYHDPDLP PSHHYLAAYRWLDTGFSNGFGAHAVVHLGKHGNLEWLPGKTLGMSASCGPDAALGDLPLIYPFLVNDPGE GTQAKRRAHAVLVDHLIPPMARAETYGDIARLEQLLDEHASVAALDPGKLPAIRQQIWTLIRAAKMDHDL GLTERPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQNPTGEQELDLVLAILRARQLFGGAHAIPGLR QALGLAEDGTDERATVDQTEAKARELVAALQATGWDPSAADRLTGNADAAAVLRFAATEVIPRLAGTATE IEQVLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRLAWEAGVALADSLLARYRDEHGRW PRSVGLSVWGTSAMRTAGDDIAEVLALLGVRPVWDDASRRVIDLAPMQPAELGRPRIDVTVRISGFFRDA FPHVVTMLDDAVRLVADLDEAAEDNYVRAHAQADLAHHGDQRRATTRIFGSKPGTYGAGLLQLIDSRSWR DDADLAQVYTAWGGFAYGRDLDGREAIDDMNRQYRRIAVAAKNTDTREHDIADSDDYFQYHGGMVATVRA LTGQAPAAYIGDNTRPDAIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYDATA GVMADWMYEQLTQRYVLDAQNRTFMTESNPWALHGMAERLLEAAGRGLWAQPAPETLDGLRQVLLETEGD LEA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2062c | cobN | - | 100% (1194) | cobaltochelatase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2088c | cobN | 0.0 | 99.92% (1194) | cobaltochelatase subunit CobN |
| M. gilvum PYR-GCK | Mflv_3112 | cobN | 0.0 | 81.70% (1202) | cobaltochelatase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2201 | cobN | 0.0 | 76.22% (1207) | cobaltochelatase subunit CobN |
| M. marinum M | MMAR_3037 | cobN | 0.0 | 89.10% (1193) | cobalamin biosynthesis protein, CobN |
| M. avium 104 | MAV_2437 | cobN | 0.0 | 89.61% (1194) | cobaltochelatase |
| M. smegmatis MC2 155 | MSMEG_3864 | cobN | 0.0 | 83.15% (1199) | cobaltochelatase |
| M. thermoresistible (build 8) | TH_0437 | cobN | 0.0 | 83.61% (1190) | Probable cobalamin biosynthesis protein cobN |
| M. ulcerans Agy99 | MUL_2277 | cobN | 0.0 | 88.26% (1193) | cobaltochelatase subunit CobN |
| M. vanbaalenii PYR-1 | Mvan_3426 | cobN | 0.0 | 83.32% (1193) | cobaltochelatase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2062c|M.tuberculosis_H37Rv MPEP--------TVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDL
Mb2088c|M.bovis_AF2122/97 MPEP--------TVLLLSTSDTDLISARSSGKNYRWANPSRLSDLELTDL
MAV_2437|M.avium_104 MAEP--------TILLLSTSDTDLISARSSGKNYRWANPSRLSDDELPDL
MMAR_3037|M.marinum_M MAEP--------TILLLSTSDTDLICARSSGRAYRWANPARLSDLELADL
MUL_2277|M.ulcerans_Agy99 MAEP--------TILLLSTSDTDLICARSSGRAYRWANPARLSDLELADL
Mflv_3112|M.gilvum_PYR-GCK MPEPVAATRMP-TVLLLSTSDTDLITARESGAAYRWANPARLVDGELDEL
Mvan_3426|M.vanbaalenii_PYR-1 MTAPDAASQTPPTVLLLSTSDTDLIAARASGAAYRWANPSRLVDGELEDL
MSMEG_3864|M.smegmatis_MC2_155 MPDPRDAVPSAPTILLLSTSDTDLITARASGAGYRWANPSRLVDGELEEL
TH_0437|M.thermoresistible__bu VAQPTAEPDTRPTVLLLSTSDTDLITARASGARYRWANPSRLVDGELDEL
MAB_2201|M.abscessus_ATCC_1997 MSDA--------PILILSTSDTDLLSARASGANYRWANPSRIHVDDLPGL
:. . .:*:********: ** ** ******:*: :* *
Rv2062c|M.tuberculosis_H37Rv LAEASIVVIRILGGYRAWQSGIDTVIAGGVPAVLVSGEQAADAELTDRST
Mb2088c|M.bovis_AF2122/97 LAEASIVVIRILGGYRAWQSGIDTVIAGGVPAALVSGEQAADAELTDRST
MAV_2437|M.avium_104 LADAAIVVVRILGGYRAWQHGIDTVLASGVPTVLVSGEQAADAELTGLST
MMAR_3037|M.marinum_M LTDAAIVVVRILGGYRAWEDGIEAVLAAGVPAVMVSGEQAADAELMDRSS
MUL_2277|M.ulcerans_Agy99 LTDAAIVVVRILGGYRAWEDGIEAVLTAGVPAVMVSGEQAADAELMDRSS
Mflv_3112|M.gilvum_PYR-GCK LRDADIVVVRILGGYRAWEDGIDAVVARGVPAVVVSGEQSPDADLMAHST
Mvan_3426|M.vanbaalenii_PYR-1 LSGADIVVVRILGGYRAWEDGIDTVVAGGLPTVVVSGEQSPDADLMNHST
MSMEG_3864|M.smegmatis_MC2_155 LAGADIAVVRILGGYRAWQDGIDAVVASGVPAVVVSGEQTPDAELMRHST
TH_0437|M.thermoresistible__bu LTGTDIAVIRILGGYRAWQDGIDTVVASGIPTVVVSGEQTPDADLMEHST
MAB_2201|M.abscessus_ATCC_1997 LDGMGAVVVRLLGGRRGWEEGIDAVIASGVPAVVVSGEQAPDAELMECST
* .*:*:*** *.*: **::*:: *:*:.:*****:.**:* *:
Rv2062c|M.tuberculosis_H37Rv VAAGTALQAHIYLAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWGV
Mb2088c|M.bovis_AF2122/97 VAAGTALQAHIYLAHGGVDNLRELHAFLCDTVLMTGFGFTPPVATPTWGV
MAV_2437|M.avium_104 PAAGIAVQAHIYLAHGGVENLRQLHAFLSDTVLMTGFGFAPPVMTPTWGE
MMAR_3037|M.marinum_M VPAGIALQAHIYLAQGGVDNLRQLHSFLCDTVLMTGVGFGPPVAIPSWGV
MUL_2277|M.ulcerans_Agy99 VPAGIALQAHVYLAQGGVDNLRQLHSFLCDTVLMTGVGFGPPVAIPSWGV
Mflv_3112|M.gilvum_PYR-GCK TPAGVALQTHIYLAQGGTANLANLHAFLSDTLLMTGFGFAEPVTTPTWGV
Mvan_3426|M.vanbaalenii_PYR-1 TPAGVALQSHIYLAQGGVENLANLHAFLSDTLLMTGFGFAEPTATPSWGV
MSMEG_3864|M.smegmatis_MC2_155 APQGAALQTHIYLAQGGLENLRNLHAFLSDTLLMTGFGFAPPVATPSWGI
TH_0437|M.thermoresistible__bu TPQGAALQAHIYLAQGGTDNLANLYAFLCDTVLMTGFGFEPPSLTPSWGL
MAB_2201|M.abscessus_ATCC_1997 VPGGVALQVHRYLAEGGTTNLRQLHAFLSDTILMTGIGFEPPATNPAWGV
. * *:* * ***.** ** :*::**.**:****.** * *:**
Rv2062c|M.tuberculosis_H37Rv LERP-----DAGKTG-PTIAVLYYRAQHLAGNTGYVEALCRAIEDAGGRP
Mb2088c|M.bovis_AF2122/97 LERP-----DAGKTG-PTIAVLYYRAQHLAGNTGYVEALCRAIEDAGGRP
MAV_2437|M.avium_104 PARP-----NAIDTDGPTIAVLYYRAQHLAGNTGYVEALCAAIEDAGARP
MMAR_3037|M.marinum_M LRRP-----DAGSTG-PTIAVLYYRAQHLAGNTAYVEALCAAIEAAGGRA
MUL_2277|M.ulcerans_Agy99 LRRP-----DAGSAG-PTIAVLYYRAQHLAGNTAYVEALCAAIEAAGGRA
Mflv_3112|M.gilvum_PYR-GCK LER------PGVVTGGPTVAVLYYRAQHLAGNTRYIEALCEAIESAGAQP
Mvan_3426|M.vanbaalenii_PYR-1 LER------KAAATGGPTVAVLYYRAQHLAGNTGYVEALCDAIESAGGSA
MSMEG_3864|M.smegmatis_MC2_155 LERPLEHAEAQSLDGAPKIAVLYYRAQQLAGNTAYVEALCRAIENAGGRP
TH_0437|M.thermoresistible__bu LER------TAVRTDGPTIAVLYYRAQHLAGNTAYVEALCEAIEAAGGRA
MAB_2201|M.abscessus_ATCC_1997 LQRE----GARATPDGPTVAVLYYRAQQLAGNIAYVDALCTAIEDHGGNA
* . *.:********:**** *::*** *** *. .
Rv2062c|M.tuberculosis_H37Rv LPLYCASLRTAEPRLLERLGGADAMVVTVLAAGGVKPAAASAGGDDDSWN
Mb2088c|M.bovis_AF2122/97 LPLYCASLRTAEPRLLERLGGADAMVVTVLAAGGVKPAAASAGGDDDSWN
MAV_2437|M.avium_104 MPIYCASLRTAEPELLQRLREADTMVVTVLAAGGLKPAEAAAGGSDDSWN
MMAR_3037|M.marinum_M LPVYCASLRTAEPELLTTLGSADAMVVTVLAAGGVKPATASAGGDDDSWN
MUL_2277|M.ulcerans_Agy99 LPAYCASLRTAEPELLTTLGSADAMVVTVLAAGGVKPATASAGGDDDSWN
Mflv_3112|M.gilvum_PYR-GCK LPVFCASLRTADDALIELLGTADALITTVLAAGGATPAAVGAGGVDDAWN
Mvan_3426|M.vanbaalenii_PYR-1 LPVFCASLRTADDALIELLGTADALVTTVLAAGGATPAAVGAGGTDDTWN
MSMEG_3864|M.smegmatis_MC2_155 LPVFCASLRTAEPELLELLGTADALITTVLAAGGATPAAVGAGGDDDSWN
TH_0437|M.thermoresistible__bu LPVYCASLRTAEPELLELLGTADALITTVLAAGGAVPAAVSAGGDDDSWN
MAB_2201|M.abscessus_ATCC_1997 LPVYCASLRTAPPELLETLAAADAMVVTVLAAGGAIPAAVGAGGADDEWS
:* :******* *: * **:::.******* ** ..*** ** *.
Rv2062c|M.tuberculosis_H37Rv VEHLAALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQVAVPEFDGRII
Mb2088c|M.bovis_AF2122/97 VEHLAALDIPILQGLCLTSPRDQWCANDDGLSPLDVASQVAVPEFDGRII
MAV_2437|M.avium_104 VEHLAALDIPILQGLCLTTPRAQWLQNDDGLSPLDVASQVAVPEFDGRII
MMAR_3037|M.marinum_M VEHLAALDIPILQGLCLTSPRAQWCANDDGLSPLDVATQVAVPEFDGRII
MUL_2277|M.ulcerans_Agy99 VEHLAALDIPILQGLCLTSPRAQWCANDDGLSPLDVATQVAVPEFDGRII
Mflv_3112|M.gilvum_PYR-GCK VAHLAALDVPILQGLCLTSSKAQWESNDDGLSPLDVATQVAVPEFDGRLI
Mvan_3426|M.vanbaalenii_PYR-1 VAHLAALDIPILQGLCLTSSKAQWDENDDGLSPLDVATQVAVPEFDGRII
MSMEG_3864|M.smegmatis_MC2_155 VAHLAALDIPILQGLCLTSSRSDWSDNDDGLSPLDVATQVAVPEFDGRII
TH_0437|M.thermoresistible__bu VAHLAALDMPILQGLCLTSSRAQWVDNDDGLSPLDVASQVAVPEFDGRII
MAB_2201|M.abscessus_ATCC_1997 VAHLAALDIPILQGLCLTSPREDWDANDDGMSPLDVATQVAVPEFDGRII
* ******:*********:.: :* ****:******:**********:*
Rv2062c|M.tuberculosis_H37Rv TVPFSFKEIDDDGLISYVADPERCARVAGLAVRHARLRQVAPADKRVALV
Mb2088c|M.bovis_AF2122/97 TVPFSFKEIDDDGLISYVADPERCARVAGLAVRHARLRQVAPADKRVALV
MAV_2437|M.avium_104 TVPFSFKEIDDDGLISYVADPERCARVAGLAVRHARLRHVGPADKRVALV
MMAR_3037|M.marinum_M TVPFSFKEIDDDGLIAYVADPERCDRVAGLALRHARLRGVDPADKRVALV
MUL_2277|M.ulcerans_Agy99 TVPFSFKEIDDDGLIAYVADPERCDRVAGLALRHARLRGVDPADKRVALV
Mflv_3112|M.gilvum_PYR-GCK TVPFSFKEIDDEGLISYVPDPERCARVAGLAVRHARLRSIAPSDKRVALV
Mvan_3426|M.vanbaalenii_PYR-1 TVPFSFKEIDDEGLISYVPDPERCARVAGLAVRHARLRSIAPADKRVALV
MSMEG_3864|M.smegmatis_MC2_155 TVPFSFKEIDHEGLISYVADPERCARVAGLAVRHARLKSIAAKDKRVALV
TH_0437|M.thermoresistible__bu TVPFSFKEIDDEGLTSYVPDRERCARVAGLAVRYARLRAVEAADKRVALV
MAB_2201|M.abscessus_ATCC_1997 TVPFSFKEIDGDGLITYVPDTERCARVAGIALRHAKLRSIPPGERRIAVV
********** :** :**.* *** ****:*:*:*:*: : . ::*:*:*
Rv2062c|M.tuberculosis_H37Rv FSAYPTKHARIGNAVGLDTPASAVALLQAMRQRGYRVG---DLPGVESN-
Mb2088c|M.bovis_AF2122/97 FSAYPTKHARIGNAVGLDTPASAVALLQAMRQRGYRVG---DLPGVESN-
MAV_2437|M.avium_104 FSAYPTKHARIGNAVGLDTPASAVALLRAMRAHGYRIG---DLPGVEAN-
MMAR_3037|M.marinum_M FSAYPTKHARIGNAVGLDTPASAVALLRAMGERGYQVG---ELPGVEAA-
MUL_2277|M.ulcerans_Agy99 FSAYPTKHARIGNAVGLDTPASAVALLRAMGERGYQVG---ELPGVEAA-
Mflv_3112|M.gilvum_PYR-GCK FSAYPTKHARIGNAVGLDTPASAIRLLTAMSDAGYDVG---EVPGLEAGD
Mvan_3426|M.vanbaalenii_PYR-1 FSAYPTKHARIGNAVGLDTPASAIAVLNAMAEAGYHVG---EIPGLEAG-
MSMEG_3864|M.smegmatis_MC2_155 FSAYPTKHARIGNAVGLDTPASAVALLRAMRAHGYDLGADDAIPGVISG-
TH_0437|M.thermoresistible__bu FSAYPTKHARIGNAVGLDTPASAVALLKALRDKGYQIG---DIPGLDAG-
MAB_2201|M.abscessus_ATCC_1997 FSAYPTKHARIGNAVGLDTPASAVALLTAMRDAGYDVGADGDIPGLPATG
***********************: :* *: ** :* :**: :
Rv2062c|M.tuberculosis_H37Rv --------DGDALIHALIECGGHDPDWLTEGQLAGNPIRVSAKEYRDWFA
Mb2088c|M.bovis_AF2122/97 --------DGDALIHALIECGGHDPDWLTEGQLAGNPIRVSAKEYRDWFA
MAV_2437|M.avium_104 --------DGDALIHALIERGGQDPDWLTEGQLAGNPIRVSAGDYRAWFA
MMAR_3037|M.marinum_M --------DGDALIHALIERGGQDPDWLTEGQLSGNPIRVSAKDYRRWFA
MUL_2277|M.ulcerans_Agy99 --------DGDALIHALIERGGQDPDWLTEGQLSGNPIRVSAKDYRRWFA
Mflv_3112|M.gilvum_PYR-GCK LGTIIASGDGDALIHAMIERGGQDPAWLTEGQLAGNPIRVSAKDYRAWFA
Mvan_3426|M.vanbaalenii_PYR-1 --------DGDALIHAMIERGGQDPAWLTEGQLAGNPIRVSAKDYRAWFA
MSMEG_3864|M.smegmatis_MC2_155 --------DGDALIHALIERGGQDAEWLTEEQLARNPIRVPAKDYREWFA
TH_0437|M.thermoresistible__bu --------DGDALMHALIERGGQDPDWVTDKQFTENPIRVSAKDYRAWFD
MAB_2201|M.abscessus_ATCC_1997 --RPAGDGDGDTLIHALIERGGQDPDWLTSDQLAGNPIRVPARQYREWFS
***:*:**:** **:*. *:*. *:: *****.* :** **
Rv2062c|M.tuberculosis_H37Rv TLPAELTDVVTAYWGPPPGELFVDRSHDPDGEIVIAALRAGNLVLMVQPP
Mb2088c|M.bovis_AF2122/97 TLPAELTDVVTAYWGPPPGELFVDRSHDPDGEIVIAALRAGNLVLMVQPP
MAV_2437|M.avium_104 TLPAEFTDAVQQHWGPPPGQLFVDRSNDPDGEIIIAAIQSGNLVLMVQPP
MMAR_3037|M.marinum_M TLPSELTDAVTQHWGPPPGELFVDRSNDPDGEIVIAAMQSGNLVLMVQPP
MUL_2277|M.ulcerans_Agy99 TLPSELTDAVTQHWGPPPGELFVDRSNDPDGEIVIAAMQSGNLVLMVQPP
Mflv_3112|M.gilvum_PYR-GCK TLPAELTDAVTEHWGPPPGELFVDRSRDPEGEIVIAAMHSGNVVLMVQPP
Mvan_3426|M.vanbaalenii_PYR-1 TLPTEFADAVVEHWGPPPGELFVDRSHDPDGEIVIAAMQAGNIVLMVQPP
MSMEG_3864|M.smegmatis_MC2_155 TLPAELADAVVEHWGPPPGHLFVDRSRDPDGEIVIAALQAGNLVIMVQPP
TH_0437|M.thermoresistible__bu TLPAEFADAVVEHWGPPPGELFVDRSRDPDGEIVIAALQAGNVVLMVQPP
MAB_2201|M.abscessus_ATCC_1997 RLAPGLAEQVVEHWGPPPGELFVDTSANPDGDIVIAALQAGNTVLLVQPP
*.. ::: * :******.**** * :*:*:*:***:::** *::****
Rv2062c|M.tuberculosis_H37Rv RGFGENPVAIYHDPDLPPSHHYLAAYRWLDTGFSNG---FGAHAVVHLGK
Mb2088c|M.bovis_AF2122/97 RGFGENPVAIYHDPDLPPSHHYLAAYRWLDTGFSNG---FGAHAVVHLGK
MAV_2437|M.avium_104 RGFGDNPVAIYHDPDLPPSHHYLAAYHWLDA----G---FGAHAVVHLGK
MMAR_3037|M.marinum_M RGFGENPVAIYHDPDLPPSHHYLAAYHWLDA----G---FGAHAVVHLGK
MUL_2277|M.ulcerans_Agy99 RGFGENPVAIYHDPDLPPSHHYLAAYHWLDA----G---FGAHAVVHLGK
Mflv_3112|M.gilvum_PYR-GCK RGFGENPVAIYHDPDLPPSHHYLAAYHWLDRGFSNG---FEADAIVHLGK
Mvan_3426|M.vanbaalenii_PYR-1 RGFGENPVAIYHDPDLPPSHHYLAAYRWLDGQFEGSSPSFRADVVVHLGK
MSMEG_3864|M.smegmatis_MC2_155 RGFGENPVAIYHDPDLPPSHHYLAAYRWLDSAFPES---FGADAVIHLGK
TH_0437|M.thermoresistible__bu RGFGENPVAIYHDPDLPPSHHYLAAYRWLDNTFPNG---FGADVVVHLGK
MAB_2201|M.abscessus_ATCC_1997 RGFGENPVAIYHDPDLPPSHHYLAAYRWLSASRDEG--GFGADALVHLGK
****:*********************:**. . * *..::****
Rv2062c|M.tuberculosis_H37Rv HGNLEWLPGKTLGMSASCGPDAALGDLPLIYPFLVNDPGEGTQAKRRAHA
Mb2088c|M.bovis_AF2122/97 HGNLEWLPGKTLGMSASCGPDAALGDLPLIYPFLVNDPGEGTQAKRRAHA
MAV_2437|M.avium_104 HGNLEWLPGKTLGLSAGCAPDAALGDLPLIYPFLVNDPGEGTQAKRRAHA
MMAR_3037|M.marinum_M HGNLEWLPGKTLGMSAACGSDAALGNLPLIYPFLVNDPGEGTQAKRRAHA
MUL_2277|M.ulcerans_Agy99 HGNLEWLPGKTLGMSAACGSDAALGNLPLIYPFLVNDPGEGIQAKRRAHA
Mflv_3112|M.gilvum_PYR-GCK HGNLEWLPGKTLGMSAACGTDAALGDQPLIYPFLVNDPGEGTQAKRRAHA
Mvan_3426|M.vanbaalenii_PYR-1 HGNLEWLPGKTLGMSAACGTDAALGDLPLVYPFLVNDPGEGTQAKRRAHA
MSMEG_3864|M.smegmatis_MC2_155 HGNLEWLPGKTLGMSAACGTDAALGDLPLIYPFLVNDPGEGTQAKRRAHA
TH_0437|M.thermoresistible__bu HGNLEWLPGKTLGMSAQCGPDAALGDLPLIYPFLVNDPGEGTQAKRRAHA
MAB_2201|M.abscessus_ATCC_1997 HGNLEWLPGKTVGLSADCATDAAIGDLPLIYPFLVNDPGEGTQAKRRAHA
***********:*:** *..***:*: **:*********** ********
Rv2062c|M.tuberculosis_H37Rv VLVDHLIPPMARAETYGDIARLEQLLDEHASVAALDPGKLPAIRQQIWTL
Mb2088c|M.bovis_AF2122/97 VLVDHLIPPMARAETYGDIARLEQLLDEHASVAALDPGKLPAIRQQIWTL
MAV_2437|M.avium_104 VLVDHLIPPMARAETYGDIARLEQLLDEHANVAALDPGKLPAIRQQIWTL
MMAR_3037|M.marinum_M VLVDHLIPPMARAETYGDIARLEQLLDEHANVAALDPAKLPAIRQQIWTL
MUL_2277|M.ulcerans_Agy99 VLVDHLIPPMARAETYGDIARLEQLLDEHANVAALDPAKLPAIRQQIWTL
Mflv_3112|M.gilvum_PYR-GCK TLVDHLIPPMARAETYGDIARLEQLLDEHANISALDPGKLPAIRQQIWTL
Mvan_3426|M.vanbaalenii_PYR-1 TLVDHLIPPMARAETYGDIARLEQLLDEHANVSALDPGKLPAIRQQIWTL
MSMEG_3864|M.smegmatis_MC2_155 TLVDHLIPPMARAETYGDIAKLEQLLDEHANVSALDPGKLPAIRQQIWTL
TH_0437|M.thermoresistible__bu TLVDHLIPPMARAETYGDIARLEQLLDEHANVSALDPAKLPAIRQQIWTL
MAB_2201|M.abscessus_ATCC_1997 TLVDHLIPPMARAETYGDIARLEQLLDEHANISALDPAKLPAIRQQIWTL
.*******************:*********.::****.************
Rv2062c|M.tuberculosis_H37Rv IRAAKMDHDLGLTERPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQN
Mb2088c|M.bovis_AF2122/97 IRAAKMDHDLGLTERPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQN
MAV_2437|M.avium_104 IRAAKMDHDLGLTERPEEDSFDDMLLHVDGWLCEIKDVQIRDGLHVLGQK
MMAR_3037|M.marinum_M IRAAKMDHDLGLTERPEEDCFDDMLLHVDGWLCEIKDVQIRDGLHILGQK
MUL_2277|M.ulcerans_Agy99 IRAAKMDHDLGLTERPEEDCFDDMLLHVDGWLCEIKDVQIRDGLHILGQK
Mflv_3112|M.gilvum_PYR-GCK MRAAKMDHDLGLEDRPDEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGET
Mvan_3426|M.vanbaalenii_PYR-1 MRAAKMDHDLGLEDRPDEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQT
MSMEG_3864|M.smegmatis_MC2_155 MRAAKMDHDLGLQDRPDEDSFDDMLLHVDGWLCEIKDVQIRDGLHVLGQK
TH_0437|M.thermoresistible__bu MRAAKMDHDLGLEERPDEDSFDDMLLHVDGWLCEIKDVQIRDGLHILGQT
MAB_2201|M.abscessus_ATCC_1997 MRAAKMDHDLGLDERPDEEVFDDMLLHVDGWLCEIKDVQIRDGLHILGSA
:*********** :**:*: *************************:**.
Rv2062c|M.tuberculosis_H37Rv PTGEQELDLVLAILRARQLFGGAHAIPGLRQALGLAEDGTD---ERATVD
Mb2088c|M.bovis_AF2122/97 PTGEQELDLVLAILRARQLFGGAHAIPGLRQALGLAEDGTD---ERATVD
MAV_2437|M.avium_104 PTGEAELDLVLAILRARQLFGGEQVIPGLRQALGLAEDGTD---ERSAVD
MMAR_3037|M.marinum_M PTGETELDLVLAILRARQLFAGAQALPGLRQALGLAEDGTD---ERAAVD
MUL_2277|M.ulcerans_Agy99 PTGETELDLVLAILRARQLFAGAQALPGLRQALGLAEDGTD---ERAAVD
Mflv_3112|M.gilvum_PYR-GCK PSDETQLDLVLAILRARQLFGGEQTVPGLREALGLIENGVEGRVERAAVD
Mvan_3426|M.vanbaalenii_PYR-1 PTGEAQLDLVLAILRARQLFGGEQTVPGLRQALGLAEDGSD---DRASVD
MSMEG_3864|M.smegmatis_MC2_155 PTGAGELDLVLAILRARQLFGGEQTVPGLRQALGLVEDGSD---DRAAVD
TH_0437|M.thermoresistible__bu PQGEAELDLVLAILRSRQLFGGEQTVPGLRQALGLSEDGRD---ERATVD
MAB_2201|M.abscessus_ATCC_1997 PEGGAQVDLVLAILRARQMWAGEQSVPGLRQALGLAEDGTD---DRSRVD
* . ::********:**::.* : :****:**** *:* : :*: **
Rv2062c|M.tuberculosis_H37Rv QTEAKARELVAALQATGWDPSAADRLTGNADAAAVLRFAATEVIPRLAGT
Mb2088c|M.bovis_AF2122/97 QTEAKARELVAALQATGWDPSAADRLTGNADAAAVLRFAATEVIPRLAGT
MAV_2437|M.avium_104 GAEAAARELVAALQATGWDPDAAGRLTNNAEAAAVLRFAAAEVVPRLAGS
MMAR_3037|M.marinum_M QTEAAARGLVAALQAADWDCAAVEQITDNPEVAAVLRFAATEVVPRLAGT
MUL_2277|M.ulcerans_Agy99 RIEAAARGLVSALQAADWDCAAVEQITDNPEAAAVLRFAATEVVPRLAGT
Mflv_3112|M.gilvum_PYR-GCK DAEARARELVAALQASGWDAGTVDSLTDDPDVAAILRFAATEVVPRLAGT
Mvan_3426|M.vanbaalenii_PYR-1 IAEAQARELVAALQDSGWDADVVDTLTDHADVAAILRFAATEVVPRLAGT
MSMEG_3864|M.smegmatis_MC2_155 AAEAGARELVAALQETGWDPAAVDTITDNPDIARILKFAATEVVPRLAGT
TH_0437|M.thermoresistible__bu AVEAAARGYVAELQASGWDPAAADRIADNPAVAEILRFAATEVVPRLAGT
MAB_2201|M.abscessus_ATCC_1997 EIDQQAHSLLTALQSASWSPDAADELTDDPQVAQILRFAATEVVPRLNGT
: *: :: ** :.*. .. ::... * :*:***:**:*** *:
Rv2062c|M.tuberculosis_H37Rv ATEIEQVLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRL
Mb2088c|M.bovis_AF2122/97 ATEIEQVLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRL
MAV_2437|M.avium_104 SAEIDQVLRALDGRFIPAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRL
MMAR_3037|M.marinum_M EAEIDQVLRALDGHFIAAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRL
MUL_2277|M.ulcerans_Agy99 EAEIDQVLRALDGHFIAVGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRL
Mflv_3112|M.gilvum_PYR-GCK AREIDQILRALDGRFIESGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRL
Mvan_3426|M.vanbaalenii_PYR-1 AGEIGQILRALDGRFIASGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRL
MSMEG_3864|M.smegmatis_MC2_155 ECEIDQVLRALDGGFIPSGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSRL
TH_0437|M.thermoresistible__bu AREIEQVLRALDGRFIEAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSKL
MAB_2201|M.abscessus_ATCC_1997 DGEIDAVLRALDGRFIEAGPSGSPLRGLVNVLPTGRNFYSVDPKAVPSKL
** :****** ** ******************************:*
Rv2062c|M.tuberculosis_H37Rv AWEAGVALADSLLARYRDEHGRWPRSVGLSVWGTSAMRTAGDDIAEVLAL
Mb2088c|M.bovis_AF2122/97 AWEAGVALADSLLARYRDEHGRWPRSVGLSVWGTSAMRTAGDDIAEVLAL
MAV_2437|M.avium_104 AWEAGVALADSLLTRYRDDHGRWPQSVGLSVWGTSAMRTAGDDIAEVLAL
MMAR_3037|M.marinum_M AWEAGAALADSLLTRYRNDHGRWPQSVGLSVWGTSAMRTAGDDIAEVLAL
MUL_2277|M.ulcerans_Agy99 AWEAGAALADSLLTRYRNDHGRWPQSVGLSVWGTSAMRTAGDDIAEVLAL
Mflv_3112|M.gilvum_PYR-GCK AWETGVAMADSLLDRYRADYGRWPESVGLSVWGTSAMRTSGDDIAEVLAL
Mvan_3426|M.vanbaalenii_PYR-1 AWETGVAMADSLLERYRTDYGRWPESVGLSVWGTSAMRTSGDDIAEVLAL
MSMEG_3864|M.smegmatis_MC2_155 AWETGVAMADSLLARYREDYGRWPQSVGLSVWGTSAMRTAGDDIAEVLAL
TH_0437|M.thermoresistible__bu AWETGVALADSLLNRFREDHGRWPESVGLSVWGTSAMRTAGDDIAEVLAL
MAB_2201|M.abscessus_ATCC_1997 AWETGQAMADSLLDRYRSDYGDWPRSVGLSIWGTSAMRTSGDDIAEVLAL
***:* *:***** *:* ::* **.*****:********:**********
Rv2062c|M.tuberculosis_H37Rv LGVRPVWDDASRRVIDLAPMQPAELGRPRIDVTVRISGFFRDAFPHVVTM
Mb2088c|M.bovis_AF2122/97 LGVRPVWDDASRRVIDLAPMQPAELGRPRIDVTVRISGFFRDAFPHVVTM
MAV_2437|M.avium_104 LGVRPVWDDASRRVVDLAPIPLTELGRPRIDVTVRISGFFRDAFPHVVTM
MMAR_3037|M.marinum_M LGVRPVWDEASRRVVDLTPIALAELGRPRIDVTVRISGFFRDAFPHVVTM
MUL_2277|M.ulcerans_Agy99 LGVRPVWDEASRRVVDLTPIALAKLGRPRIDVTVRISGFFRDAFPHVVTM
Mflv_3112|M.gilvum_PYR-GCK LGVRPIWDEASRRVVDLAAISLEELGRPRIDVTVRISGFFRDAFPHVVAM
Mvan_3426|M.vanbaalenii_PYR-1 LGVRPIWDDASRRVVDLEAIPLAELGRPRIDVTVRISGFFRDAFPHVVAM
MSMEG_3864|M.smegmatis_MC2_155 LGVRPVWDDASRRVVNLEPIDLAELGRPRIDVTVRISGFFRDAFPHVVTM
TH_0437|M.thermoresistible__bu LGVRPIWDDASRRVVDLEPIPLDELGRPRIDVTVRISGFFRDAFPHVVTM
MAB_2201|M.abscessus_ATCC_1997 LGVRPVWDDASRRVVSLEAIPLAELGRPRIDVTVRISGFFRDAFPHVVTM
*****:**:*****:.* .: :************************:*
Rv2062c|M.tuberculosis_H37Rv LDDAVRLVADLDEAAEDNYVRAHAQADLAHHGDQRRATTRIFGSKPGTYG
Mb2088c|M.bovis_AF2122/97 LDDAVRLVADLDEAAEDNYVRAHAQADLAHHGDQRRATTRIFGSKPGTYG
MAV_2437|M.avium_104 LDDAVRLVAGLGEPAADNYVRAHAQADLAQHGDQRRATTRIFGSKPGTYG
MMAR_3037|M.marinum_M LDDAVRLVAELDEPAEDNYVRAHAQADLAQHGDQRRATTRIFGSKPGTYG
MUL_2277|M.ulcerans_Agy99 LDDAVRLVAELDEPAEDNYVRAHAQADLAQHGDQRRATTRIFGSKPGTYG
Mflv_3112|M.gilvum_PYR-GCK LDDAVQLVAALDEPDTDNYVRAHAQVDMAEHGDRRRATTRIFGSKPGTYG
Mvan_3426|M.vanbaalenii_PYR-1 LDDAVQLVAGLDEPAEDNFVRAHAQVDLSEHGDQRRATTRIFGSKPGTYG
MSMEG_3864|M.smegmatis_MC2_155 LDDAVALVAALDEPAEHNYVRAHAQADLAEHGDERRATTRIFGSKPGTYG
TH_0437|M.thermoresistible__bu LDDAVQLVAGLDEPAEHNYVRAHAQADLAEHGDHRRATTRIFGSKPGTYG
MAB_2201|M.abscessus_ATCC_1997 LDDAVALAAGLDEPAAQNYLRAHAETDRAEHGDWRRATMRIFGSKPGTYG
***** *.* *.*. .*::****:.* :.*** **** ***********
Rv2062c|M.tuberculosis_H37Rv AGLLQLIDSRSWRDDADLAQVYTAWGGFAYGRDLDGREAIDDMNRQYRRI
Mb2088c|M.bovis_AF2122/97 AGLLQLIDSRSWRDDADLAQVYTAWGGFAYGRDLDGREAIDDMNRQYRRI
MAV_2437|M.avium_104 AGLLQLIDSRNWRDDADLAAVYTAWGGFAYGRDLDGREAVDDMNRQYRRI
MMAR_3037|M.marinum_M AGLLQLIDSRNWRDDADLAQVYTAWGGFAYGRDLEGREAVDDMNRQYRRI
MUL_2277|M.ulcerans_Agy99 AGLLQLIDSRNWRDDADLAQVYTAWGGFAYGRDLEGREAVDDMDRQYRRI
Mflv_3112|M.gilvum_PYR-GCK AGLLQLIDSRNWRDDADLAQVYTAWGGFAYGRGLDGAPATDDMNRAYRRI
Mvan_3426|M.vanbaalenii_PYR-1 AGLLQLIDSRNWRDDADLAAVYTAWGGFAYGRGLDGAPATDDMNRAYRRI
MSMEG_3864|M.smegmatis_MC2_155 AGLLQLIDSRNWRDDADLAQVYTAWGGFAYGRGLDGAAASDDMNRAYRRI
TH_0437|M.thermoresistible__bu AGLLQLIDSRNWRDDADLAQVYTAWGGFAYGRGLDGAPAADDMTRQYRRI
MAB_2201|M.abscessus_ATCC_1997 AGLLQLIDSQNWRNDSDLEQVYTAWGGFAYGRGLDGAAASEDMRHQYRRI
*********:.**:*:** ************.*:* * :** : ****
Rv2062c|M.tuberculosis_H37Rv AVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGQAPAAYIGDNTRPD
Mb2088c|M.bovis_AF2122/97 AVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGQAPAAYIGDNTRPD
MAV_2437|M.avium_104 AVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGQAPAAYIGDNTRPD
MMAR_3037|M.marinum_M AVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGQAPAAYIGDNTRPD
MUL_2277|M.ulcerans_Agy99 AVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGQAPAAYIGDNTRPD
Mflv_3112|M.gilvum_PYR-GCK AVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGKDPAAYIGDNTRPD
Mvan_3426|M.vanbaalenii_PYR-1 AVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGKDPAAYIGDNTRPD
MSMEG_3864|M.smegmatis_MC2_155 AVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGKAPAAYIGDNTRPD
TH_0437|M.thermoresistible__bu VVAAKNTDTREHDIADSDDYFQYHGGMVATVRALTGKDPAAYIGDNTRPD
MAB_2201|M.abscessus_ATCC_1997 AVAAKNTDTREHDIADSDDYFQYHGGMVAAVRALTGKAPAAYIGDNTRPD
.****************************:******: ************
Rv2062c|M.tuberculosis_H37Rv AIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYD
Mb2088c|M.bovis_AF2122/97 AIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYD
MAV_2437|M.avium_104 AIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYD
MMAR_3037|M.marinum_M AIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEMAATVDYLFGYD
MUL_2277|M.ulcerans_Agy99 AIRTRTLSEETTRVFRARVVNPRWMAAMRRHGYKGAFEMAATIDYLFGYD
Mflv_3112|M.gilvum_PYR-GCK AVRTRTLSEETTRVFRARVVNPRWINAMRRHGYKGAFEMAATVDYLFGYD
Mvan_3426|M.vanbaalenii_PYR-1 AVRTRTLSEETTRVFRARVVNPRWITAMRRHGYKGAFEMAATVDYLFGYD
MSMEG_3864|M.smegmatis_MC2_155 AVRTRTLSEETNRVFRARVVNPRWINAMRRHGYKGAFEMAATVDYLFGYD
TH_0437|M.thermoresistible__bu SVRTRTLHEETARVFRARVVNPRWMNAMRRHGYKGAFEMAATVDYLFGYD
MAB_2201|M.abscessus_ATCC_1997 SVRTRTLSEETTRVFRARVVNPRWLEAMRRHGYKGAFEMAATVDYLFGYD
::***** *** ************: ****************:*******
Rv2062c|M.tuberculosis_H37Rv ATAGVMADWMYEQLTQRYVLDAQNRTFMTESNPWALHGMAERLLEAAGRG
Mb2088c|M.bovis_AF2122/97 ATAGVMADWMYEQLTQRYVLDAQNRTFMTESNPWALHGMAERLLEAAGRG
MAV_2437|M.avium_104 ATAGVMADWMYEQLTERYVLDPENRKFMAESNPWALHGMAERLLEAAGRG
MMAR_3037|M.marinum_M ATAGVMADWMYEQLTERYVLDPENRKFMTESNPWALHGMAERLLEAAGRG
MUL_2277|M.ulcerans_Agy99 ATAGVMADWMYEQLTERYVLDPENRKFMTESNPWALHGMAERLLEAAGRG
Mflv_3112|M.gilvum_PYR-GCK ATAGVMADWMYEQLSQSYVLDDENRKFMNESNPWALHGMAERLLEAAGRG
Mvan_3426|M.vanbaalenii_PYR-1 ATAGVMADWMYEQLSQSYVLDDENRKFMAESNPWALHGMAERLLEAAGRG
MSMEG_3864|M.smegmatis_MC2_155 ATAHVMADWMYERLAGEYVLDDENRKFMNESNPWALHGMAERLLEAATRG
TH_0437|M.thermoresistible__bu ATANVMADWMYEQLTQQYVLDEENRKFMAESNPWALHGMAERLLEAAGRG
MAB_2201|M.abscessus_ATCC_1997 ATANVMADWMYEQLTNSYVLDEQNRKFMQQSNPWALHGIAERLLEAASRG
*** ********:*: **** :**.** :********:******** **
Rv2062c|M.tuberculosis_H37Rv LWAQPAPETLDGLRQVLLETEGDLEA
Mb2088c|M.bovis_AF2122/97 LWAQPAPETLDGLRQVLLETEGDLEA
MAV_2437|M.avium_104 MWAQPQPETLDGLRQALLETEGDLEG
MMAR_3037|M.marinum_M MWAQPQPETLDGLRQALLETEGDLEG
MUL_2277|M.ulcerans_Agy99 MWAQPQPETLDGLRQALLETEGDLEG
Mflv_3112|M.gilvum_PYR-GCK MWAAPEQATLDGLRQVLLETEGDLEG
Mvan_3426|M.vanbaalenii_PYR-1 MWAAPEQATLDGLKQVLLETEGDLEG
MSMEG_3864|M.smegmatis_MC2_155 MWAEPEPATLDGLRQVLLETEGELEG
TH_0437|M.thermoresistible__bu MWEKPEASTLDALRQVLLETEGELEG
MAB_2201|M.abscessus_ATCC_1997 LWEKPDQQVLDDLRNVFLETEGELES
:* * .** *::.:*****:**.