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VARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTTALTVVTDSERAWVSRGAHKL VGALEAFAIAVAGRRCLDAGASTGGFTEVLLDRGAAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLT PEAIGGRVDLVVADLSFISLATVLPALVGCASRDADIVPLVKPQFEVGKGQVGPGGVVHDPQLRARSVLA VARRAQELGWHSVGVKASPLPGPSGNVEYFLWLRTQTDRALSAKGLEDAVHRAISEGP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1694 | tlyA | - | 100% (268) | CYTOTOXIN|HAEMOLYSIN HOMOLOGUE TLYA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1720 | tlyA | 1e-149 | 100.00% (268) | cytotoxin |
| M. gilvum PYR-GCK | Mflv_3509 | - | 1e-108 | 74.63% (268) | hemolysin A |
| M. leprae Br4923 | MLBr_01358 | tlyA | 1e-114 | 78.73% (268) | cytotoxin/hemolysin |
| M. abscessus ATCC 19977 | MAB_2359 | - | 1e-97 | 69.00% (271) | cytotoxin/hemolysin TlyA |
| M. marinum M | MMAR_2499 | tlyA | 1e-121 | 81.34% (268) | cytotoxin/hemolysin, TlyA |
| M. avium 104 | MAV_3077 | - | 1e-117 | 79.48% (268) | hemolysin A |
| M. smegmatis MC2 155 | MSMEG_3751 | - | 1e-113 | 76.87% (268) | hemolysin A |
| M. thermoresistible (build 8) | TH_1550 | tlyA | 1e-108 | 73.51% (268) | HAEMOLYSIN HOMOLOGUE TLYA |
| M. ulcerans Agy99 | MUL_1683 | tlyA | 1e-121 | 81.72% (268) | cytotoxin/hemolysin, TlyA |
| M. vanbaalenii PYR-1 | Mvan_3290 | - | 1e-111 | 76.12% (268) | hemolysin A |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1694|M.tuberculosis_H37Rv MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTT
Mb1720|M.bovis_AF2122/97 MARRARVDAELVRRGLARSRQQAAELIGAGKVRIDGLPAVKPATAVSDTT
MLBr_01358|M.leprae_Br4923 MARRVRVDVELVRRGLARSRQQAAKLISAGKVSIDGLPAVKPSTAVAITT
MMAR_2499|M.marinum_M MARRTRVDAELVRRGLARSRQQAAELISAGKVRIDGLPAVKPATAVAATA
MUL_1683|M.ulcerans_Agy99 MARRTRVDAELVRRGLARSRQQAAELISAGKVRIDGLPAVKPATAVAATA
MAV_3077|M.avium_104 MSRRARVDAELVRRGLARSRQQAAELIGAGRVSIDGMPARKPGTAVAVTA
Mflv_3509|M.gilvum_PYR-GCK MTRRARVDAELVRRGLARSRQQAAELISAGKVRVDGMPAAKPATAVSVTA
Mvan_3290|M.vanbaalenii_PYR-1 MSRRARVDAELVRRGLARSRQQAAELIGAGRVRIDGMPAAKPATAVSLTA
TH_1550|M.thermoresistible__bu VTRRARVDAELVRRGLARSRQQAAELISAGRVCVDGIPARKPATAVAVTA
MSMEG_3751|M.smegmatis_MC2_155 MARRARVDAELVRRGLARSRQQAAELIGAGRVRIDGMPAAKPATAVSVDA
MAB_2359|M.abscessus_ATCC_1997 MARHARVDAELVRRGLARSRQQAAELIEAGRVRIDGIPAVKAATAVPATA
::*:.***.***************:** **:* :**:** *..***. :
Rv1694|M.tuberculosis_H37Rv ALTVVTDSERAWVSRGAHKLVGALEAFA---IAVAGRRCLDAGASTGGFT
Mb1720|M.bovis_AF2122/97 ALTVVTDSERAWVSRGAHKLVGALEAFA---IAVAGRRCLDAGASTGGFT
MLBr_01358|M.leprae_Br4923 VLTVADDGERSWVSRGAHKLMGALDTFG---IPVAGRCCLDAGASTGGFT
MMAR_2499|M.marinum_M ALTVAADSERGWVSRGAHKLIGALDAFG---IDVHGRRCLDAGASTGGFT
MUL_1683|M.ulcerans_Agy99 ALTVAADSERGWVSRGAHKLIGALDAFG---IDVHGRRCLDAGASTGGFT
MAV_3077|M.avium_104 ALTVAADGERGWVSRGAHKLLGALDAFE---IAVAGRRCLDAGASTGGFT
Mflv_3509|M.gilvum_PYR-GCK NLSVEAGDEDSWVSRGAHKLIGALDVFG---LTVAGRRCLDAGASTGGFT
Mvan_3290|M.vanbaalenii_PYR-1 NLTVEGGDADSWVSRGAHKLIGALDAFG---LSVRARRCLDAGASTGGFT
TH_1550|M.thermoresistible__bu HLTVTGADEREWVSRGAHKLIGALDAFD---VGVEGRRCLDAGASTGGFT
MSMEG_3751|M.smegmatis_MC2_155 NLTVIESDERTWVSRGAHKLIGALDAFG---LSVEGRRCLDAGASTGGFT
MAB_2359|M.abscessus_ATCC_1997 SLVVQGEAGDRWVSRGAHKLLGALEVFGPQGLSVEGKRCLDAGASTGGFT
* * *********:***:.* : * .: ************
Rv1694|M.tuberculosis_H37Rv EVLLDRGAAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLTPEAIGGR
Mb1720|M.bovis_AF2122/97 EVLLDRGAAHVVAADVGYGQLAWSLRNDPRVVVLERTNARGLTPEAIGGR
MLBr_01358|M.leprae_Br4923 EVLLDRGAAEVVAVDVGYGQLAWSVRCDPRVIVVERTNVHDLSPELIGGP
MMAR_2499|M.marinum_M DVLLDRGAAEVVAADVGYGQLAWSLRTDPRVIVIERTNVRDLSPAAIGGQ
MUL_1683|M.ulcerans_Agy99 EVLLDRGAAEVVAADVGYGQLAWSLRTDPRVIVIERTNVRDLSPAAIGGQ
MAV_3077|M.avium_104 EVLLDRGAAEVVAVDVGYGQLAWSLRSDARVVVVERTNVRDLTPEAIGGP
Mflv_3509|M.gilvum_PYR-GCK EVLLSRDVREVVAVDVGYGQLAWSVRTDPRVTVMERTNVRDLTAEAIGGP
Mvan_3290|M.vanbaalenii_PYR-1 EVLLDREAREVVAVDVGYGQLAWSLRTDPRVTVMDRTNVRELTPEAIGGP
TH_1550|M.thermoresistible__bu EVLLDRGAREVVAVDVGYGQLAWSLRTDPRVTVLERTNVRDLTPDAIGGP
MSMEG_3751|M.smegmatis_MC2_155 EVLLDRGAAEVVAADVGYGQLAWSLRSDPRVHVLERTNVRDLTPEAIGGP
MAB_2359|M.abscessus_ATCC_1997 EVLLRSGAREVVAADVGYGQLAWSLQSDDRVTVLDRTNVRTLTPALIGGT
:*** . .***.**********:: * ** *::***.: *:. ***
Rv1694|M.tuberculosis_H37Rv VDLVVADLSFISLATVLPALVGCASRDADIVPLVKPQFEVGKGQVGPGGV
Mb1720|M.bovis_AF2122/97 VDLVVADLSFISLATVLPALVGCASRDADIVPLVKPQFEVGKGQVGPGGV
MLBr_01358|M.leprae_Br4923 VDLVVADLSFISLATVLSALAGCALPSADIVPMVKPQFEVGKGQVGPGGV
MMAR_2499|M.marinum_M VDLVVADLSFISLTTVLPALAACALPHADIVPMVKPQFEVGKGQVGAGGV
MUL_1683|M.ulcerans_Agy99 VDLVVADLSFISLTTVLPALAACALPHADIVPMVKPQFEVGKGQVGAGGV
MAV_3077|M.avium_104 ADLVVADLSFISLCTVLPALAGCAAPHADIVPMVKPQFEVGKGQVGPGGV
Mflv_3509|M.gilvum_PYR-GCK VDLVVADLSFISLATVLPALAACASPGADIVPMVKPQFEVGKDRVGAGGV
Mvan_3290|M.vanbaalenii_PYR-1 VDLVVADLSFISLATVLPALTACASPDADIVPMVKPQFEVGKDRVGPGGV
TH_1550|M.thermoresistible__bu AELIVADLSFISLTTVLPALTRCATADADMVPMVKPQFEVGKDRVGAGGV
MSMEG_3751|M.smegmatis_MC2_155 VQMIVADLSFISLATVLPALTACAVRDADIVPMVKPQFEVGKDRVGAGGV
MAB_2359|M.abscessus_ATCC_1997 AQLIVSDLSFISLALVLDALIACAGPDADILPMVKPQFEVGKELVGAGGV
.:::*:******* ** ** ** **::*:********* **.***
Rv1694|M.tuberculosis_H37Rv VHDPQLRARSVLAVARRAQELGWHSVGVKASPLPGPSGNVEYFLWLRTQT
Mb1720|M.bovis_AF2122/97 VHDPQLRARSVLAVARRAQELGWHSVGVKASPLPGPSGNVEYFLWLRTQT
MLBr_01358|M.leprae_Br4923 VRDLRLRADSVLAVARRATELGWRTMDVTASSLPGLSGNVEYFLWLRAQT
MMAR_2499|M.marinum_M VQDPALRAGAVLSVARRAGELGWHTVGVTASPLPGPSGNVEYFLWLRAQT
MUL_1683|M.ulcerans_Agy99 VQDPALRAGAVLSVARRAGELGWHTVGVTASPLPGPSGNVEYFLWLRAQT
MAV_3077|M.avium_104 VNDPELRAQAVLSVARRADELGWHPVDVTASPLPGPSGNVEYFLRLRART
Mflv_3509|M.gilvum_PYR-GCK VSDPQLRVDAVLSVARRAASLNWHAVAVTASPLPGPAGNVEYFLHLRAR-
Mvan_3290|M.vanbaalenii_PYR-1 VSDPLLRAEAVLSVARRAAELNWHAVAVTASPLPGPAGNVEYFIHLRSDG
TH_1550|M.thermoresistible__bu VSDPGLRVTAVLSVAHRAADLGWSTVGVVASPLPGPAGNVEYFLHLRRDR
MSMEG_3751|M.smegmatis_MC2_155 VSDPELRIDAVCTVGRKAAALQWHAVDVTASPLPGPSGNVEYFLRLRAET
MAB_2359|M.abscessus_ATCC_1997 VRDPQLRADAVVSVARRARSQGWFTAGVTASPLPGPSGNVEYFLWLRRT-
* * ** :* :*.::* * . * **.*** :******: **
Rv1694|M.tuberculosis_H37Rv DRALSAKGLEDAVHRAISEGP-------------
Mb1720|M.bovis_AF2122/97 DRALSAKGLEDAVHRAISEGP-------------
MLBr_01358|M.leprae_Br4923 DLELSTDGLEAAVQRAIAEGPQ------------
MMAR_2499|M.marinum_M DRPLSDDTLSDAIQTAVAEGPGREPAGHAERGPQ
MUL_1683|M.ulcerans_Agy99 DRPLSDDTLSDAIQTAVAEGPGREPAGHAERGPQ
MAV_3077|M.avium_104 DRPLAGDALCRAVRRAVESGPQ------------
Mflv_3509|M.gilvum_PYR-GCK ADAMSQDALEGAVRRAVDEGPQ------------
Mvan_3290|M.vanbaalenii_PYR-1 AHRLQADALEAAVRRAVDEGPQ------------
TH_1550|M.thermoresistible__bu DGALTGAALDAAVDRAVTEGPQ------------
MSMEG_3751|M.smegmatis_MC2_155 DSPLEGDALEAAVRRAVEEGPQ------------
MAB_2359|M.abscessus_ATCC_1997 ---DSDVDVEAAVAEAVSRGPQ------------
: *: *: **