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VSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTTGQVHVVGEVTTSAKEAFADI TNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQSPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFG YAINATPELMPLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVVISTQHAADID LEKTLDPDIREKVLNTVLDDLAHETLDASTVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGG GAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAI GEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDLKRAI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1392 | metK | - | 100% (403) | S-adenosylmethionine synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1427 | metK | 0.0 | 99.75% (403) | S-adenosylmethionine synthetase |
| M. gilvum PYR-GCK | Mflv_3737 | - | 0.0 | 86.75% (400) | S-adenosylmethionine synthetase |
| M. leprae Br4923 | MLBr_00544 | metK | 0.0 | 91.56% (403) | S-adenosylmethionine synthetase |
| M. abscessus ATCC 19977 | MAB_2820c | - | 0.0 | 84.91% (391) | S-adenosylmethionine synthetase (methionine |
| M. marinum M | MMAR_2205 | metK | 0.0 | 95.04% (403) | s-adenosylmethionine synthetase MetK |
| M. avium 104 | MAV_3382 | metK | 0.0 | 92.06% (403) | S-adenosylmethionine synthetase |
| M. smegmatis MC2 155 | MSMEG_3055 | metK | 0.0 | 87.00% (400) | S-adenosylmethionine synthetase |
| M. thermoresistible (build 8) | TH_0824 | metK | 0.0 | 88.72% (399) | PROBABLE S-ADENOSYLMETHIONINE SYNTHETASE METK (MAT) (AdoMet |
| M. ulcerans Agy99 | MUL_1791 | metK | 0.0 | 94.79% (403) | S-adenosylmethionine synthetase |
| M. vanbaalenii PYR-1 | Mvan_2670 | - | 0.0 | 87.44% (398) | S-adenosylmethionine synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1392|M.tuberculosis_H37Rv MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTT
Mb1427|M.bovis_AF2122/97 MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTT
MMAR_2205|M.marinum_M MSEKGRLFTSESVTEGHPDKICDAVSDSVLDALLAADPRSRVAVETLVTT
MUL_1791|M.ulcerans_Agy99 MSEKGRLFTSESVTEGHPDKICDAVSDSVLDALLAADPRSRVAVETLVTT
MLBr_00544|M.leprae_Br4923 MSEKGRLFTSESVTEGHPDKICDAISDSILDALLAEDPCSRVAVETLVTT
MAV_3382|M.avium_104 MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAQDPRSRVAVETLVTT
MAB_2820c|M.abscessus_ATCC_199 ------------MTEGHPDKICDAISDSILDAMLAQDPKSRVAVETLVTT
Mflv_3737|M.gilvum_PYR-GCK -MSEARLFTSESVTEGHPDKICDAISDSVLDALLAGDPKSRVAVETLVTT
Mvan_2670|M.vanbaalenii_PYR-1 -MSDARLFTSESVTEGHPDKICDAISDSVLDALLADDPKSRVAVETLVTT
MSMEG_3055|M.smegmatis_MC2_155 -MSKGRLFTSESVTEGHPDKICDAISDSVLDALLEQDPKSRVAVETLVTT
TH_0824|M.thermoresistible__bu -VSTGRLFTSESVTEGHPDKICDAISDSVLDALLAQDPNSRVAVETLVTT
:***********:***:***:* ** ***********
Rv1392|M.tuberculosis_H37Rv GQVHVVGEVTTSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIG
Mb1427|M.bovis_AF2122/97 GQVHVVGEVATSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIG
MMAR_2205|M.marinum_M GQVHVVGEVTTTAKEAFADITNIVRERILDIGYDSSDKGFDGASCGVNIG
MUL_1791|M.ulcerans_Agy99 GQVHVVGEVTTTAKEAFADITNIVRERILDIGYDSSDKGFDGASCGVNIG
MLBr_00544|M.leprae_Br4923 GQVHVVGEVTTLAKTAFADISNTVRERILDIGYDSSDKGFDGASCGVNIG
MAV_3382|M.avium_104 GQVHVVGEVTTTAKEAFADITNTVRERILDIGYDSSDKGFDGASCGVNIG
MAB_2820c|M.abscessus_ATCC_199 GQVHVAGEVTT---SAYVDIPHIVRERVLEIGYDSSSKGFDGNSCGVNVA
Mflv_3737|M.gilvum_PYR-GCK GQVHVVGEVTTNAKEAFADITNTVRERILEIGYDHSDKGFDGETCGVNIG
Mvan_2670|M.vanbaalenii_PYR-1 GQVHVVGEVTTTAKAAFADITNTVRERILEIGYDHSDKGFDGLTCGVNIG
MSMEG_3055|M.smegmatis_MC2_155 GQVHVAGEVTT---TAYADIPKIVRDRILDIGYDSSTKGFDGASCGVNVA
TH_0824|M.thermoresistible__bu GQVHVVGEVTTNAKEAFADITNTVRERILDIGYDSSEKGFDGATCGVNIG
*****.***:* *:.**.: ** *:*:**** * ***** :****:.
Rv1392|M.tuberculosis_H37Rv IGAQSPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELM
Mb1427|M.bovis_AF2122/97 IGAQSPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELM
MMAR_2205|M.marinum_M IGAQSPDIAQGVDTAHEARVEGAADPLDAQGAGDQGLMFGYAINDTPELM
MUL_1791|M.ulcerans_Agy99 IGAQSPDIAQGVDTAHEARVEGAADPLDAQGAGDQGLMFGYAINDTPELM
MLBr_00544|M.leprae_Br4923 IGAQSSDIAQGVNTAHEVRVEGAADPLDAQGAGDQGLMFGYAINDTPELM
MAV_3382|M.avium_104 IGAQSPDIAQGVDTAHETRVEGAADPLDAQGAGDQGLMFGYAINDTPERM
MAB_2820c|M.abscessus_ATCC_199 IGAQSPDIAQGVDTAHEARVEGAADPLDAQGAGDQGLMFGYAINDTPELM
Mflv_3737|M.gilvum_PYR-GCK IGRQSPDIAQGVDTAHETRVGGAADPLDSQGAGDQGLMFGYAIADTPELM
Mvan_2670|M.vanbaalenii_PYR-1 IGKQSPDIAQGVDTAHETRVEGAADPLDSQGAGDQGLMFGYAIADTPELM
MSMEG_3055|M.smegmatis_MC2_155 IGAQSPDIAQGVDTAHETRVEGKADPLDLQGAGDQGLMFGYAIGDTPELM
TH_0824|M.thermoresistible__bu IGAQSPDIAQGVDTAHEARVEGAADPLDTQGAGDQGLMFGYAIRDTPELM
** **.******:****.** * ***** ************** *** *
Rv1392|M.tuberculosis_H37Rv PLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVV
Mb1427|M.bovis_AF2122/97 PLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVV
MMAR_2205|M.marinum_M PLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDRVPVRLDTVV
MUL_1791|M.ulcerans_Agy99 PLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDRVPVRLDTVV
MLBr_00544|M.leprae_Br4923 PLPIALAHRLARRLTEVRKNGVLPYLRSDGKTQVTIAYEDNVPVRLDTVV
MAV_3382|M.avium_104 PLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIEFEDDVPVRLDTVV
MAB_2820c|M.abscessus_ATCC_199 PLPIALAHRLSRRLTEVRKDGLLPYLRPDGKTQVTIEYDGNKAVRLDTVV
Mflv_3737|M.gilvum_PYR-GCK PLPIALAHRLSRKLTEVRKNGTLDYLRPDGKTQVTVQYDGTTPVRLDTVV
Mvan_2670|M.vanbaalenii_PYR-1 PLPIALAHRLSRKLTEVRKNGTLDYLRPDGKTQVTVQYDGTTPVRLDTVV
MSMEG_3055|M.smegmatis_MC2_155 PLPIALAHRLARRLTEVRKNGVLDYLRPDGKTQVTIQYDGTTPVRLDTVV
TH_0824|M.thermoresistible__bu PLPIALAHRLARRLTEVRKNGVLPYLRPDGKTQVTIQYDGTRPVRLDTVV
**********:*:******:* * ***.*******: ::. .*******
Rv1392|M.tuberculosis_H37Rv ISTQHAADIDLEKTLDPDIREKVLNTVLDDLAHETLDASTVRVLVNPTGK
Mb1427|M.bovis_AF2122/97 ISTQHAADIDLEKTLDPDIREKVLNTVLDDLAHETLDASTVRVLVNPTGK
MMAR_2205|M.marinum_M ISTQHADDIDLVKTLDPDIREQVLKTVLDDLAHDTLDASAVRVLVNPTGK
MUL_1791|M.ulcerans_Agy99 ISTQHADDIDLVKTLDPDIREQVLKTVLDDLAHDTLDASAVRVLVNPTGK
MLBr_00544|M.leprae_Br4923 ISTQHAAGVDLDATLAPDIREKVLNTVIDDLSHDTLDVSSVRVLVNPTGK
MAV_3382|M.avium_104 ISTQHAADIDLENTLTPDIREKVLNTVLNDLAHDTLDTSSTRLLVNPTGK
MAB_2820c|M.abscessus_ATCC_199 LSTQHAADIDLENLLTPDIREKVVQVVLDELNQDGLDISDYRLLVNPTGK
Mflv_3737|M.gilvum_PYR-GCK LSTQHADGIELDSQLEPEIKQHVIDAVLTELGHQTLDTSNPRILVNPTGK
Mvan_2670|M.vanbaalenii_PYR-1 LSTQHADGIDLESQLAPEIKQHVIDAVLTELGHDTLDTSAPRILVNPTGK
MSMEG_3055|M.smegmatis_MC2_155 LSTQHADGIDLEGTLTPDIREKVVNTVLADLGHETLDTSDYRLLVNPTGK
TH_0824|M.thermoresistible__bu LSTQHAPDVDLDETLAPEIREKVVNTVLDDLGHDTVDTSDYRLLVNPTGK
:***** .::* * *:*:::*:..*: :* :: :* * *:*******
Rv1392|M.tuberculosis_H37Rv FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
Mb1427|M.bovis_AF2122/97 FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
MMAR_2205|M.marinum_M FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
MUL_1791|M.ulcerans_Agy99 FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
MLBr_00544|M.leprae_Br4923 FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
MAV_3382|M.avium_104 FVVGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
MAB_2820c|M.abscessus_ATCC_199 FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
Mflv_3737|M.gilvum_PYR-GCK FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
Mvan_2670|M.vanbaalenii_PYR-1 FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
MSMEG_3055|M.smegmatis_MC2_155 FVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMR
TH_0824|M.thermoresistible__bu FVLGGPMGDAGLTGRKIIVDTYGGFARHGGGAFSGKDPSKVDRSAAYAMR
**:*********************:*************************
Rv1392|M.tuberculosis_H37Rv WVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAI
Mb1427|M.bovis_AF2122/97 WVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAI
MMAR_2205|M.marinum_M WVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGSEAVDPVKIEKAI
MUL_1791|M.ulcerans_Agy99 WVAKNVVAAGLAEGVEVQVAYAIGKAAPVGLFVETFGSEAVDPVKIEKAI
MLBr_00544|M.leprae_Br4923 WVAKNIVAAGLAERIEVQVAYAIGKAAPVGLFVETFGTEAVDPAKIEKAI
MAV_3382|M.avium_104 WVAKNIVAAGLAERVEVQVAYAIGKAAPVGLFIETFGTATVDPVKIEKIV
MAB_2820c|M.abscessus_ATCC_199 WVAKNVVAAGLADRAEVQVAYAIGKAAPVGLFVDTFGTATVDQAKIEKAI
Mflv_3737|M.gilvum_PYR-GCK WVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGSETVDPVKIEKAI
Mvan_2670|M.vanbaalenii_PYR-1 WVAKNVVAAGLAQRVEVQVAYAIGKAAPVGLFVETFGSETVDPVKIQKAI
MSMEG_3055|M.smegmatis_MC2_155 WVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGSETVDPAKIEKAI
TH_0824|M.thermoresistible__bu WVAKNVVAAGLADRIEVQVAYAIGKAAPVGLFVETFGSETVDPAKIERAI
*****:******: *****************::***: : * .**:: :
Rv1392|M.tuberculosis_H37Rv GEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDLK
Mb1427|M.bovis_AF2122/97 GEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDLK
MMAR_2205|M.marinum_M GEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVDLPWERLDKVDDLK
MUL_1791|M.ulcerans_Agy99 GEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVDLPWERLDKVDDLK
MLBr_00544|M.leprae_Br4923 GEVFDLRPGAIIRDLHLLRPIYAQTAAYGHFGRTDVELPWEQLNKVDDLK
MAV_3382|M.avium_104 PEVFDLRPGAIIRDLDLLRPIYAQTAAYGHFGRTDVELPWEQLNKVDDLK
MAB_2820c|M.abscessus_ATCC_199 NEVFDLRPGAIIRDLDLLRPIYAQTAAYGHFGRTDVELPWEQTDRVDALK
Mflv_3737|M.gilvum_PYR-GCK GEVFDLRPGAIVRDLDLLRPIYAPTAAYGHFGRTDIELPWEQLNKVDDLK
Mvan_2670|M.vanbaalenii_PYR-1 GEVFDLRPGAIVRDLDLLRPIYAPTAAYGHFGRTDIELPWEQLDKVDDLK
MSMEG_3055|M.smegmatis_MC2_155 GEVFDLRPAAIVRDLDLLRPIYAPTAAYGHFGRTDIELPWEQTNKVDDLK
TH_0824|M.thermoresistible__bu LEVFDLRPGAIIRDLDLLRPIYAPTAAYGHFGRTDVDLPWERLDKVEALK
*******.**:***.******* ***********::****: ::*: **
Rv1392|M.tuberculosis_H37Rv RAI
Mb1427|M.bovis_AF2122/97 RAI
MMAR_2205|M.marinum_M RAI
MUL_1791|M.ulcerans_Agy99 RAI
MLBr_00544|M.leprae_Br4923 RAI
MAV_3382|M.avium_104 RAI
MAB_2820c|M.abscessus_ATCC_199 AAI
Mflv_3737|M.gilvum_PYR-GCK SAV
Mvan_2670|M.vanbaalenii_PYR-1 AAV
MSMEG_3055|M.smegmatis_MC2_155 SAI
TH_0824|M.thermoresistible__bu SVI
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