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SHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPV NRWLMEQLIMIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQ IQGFFDGPVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQ VVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIV TNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTGLFDGDA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1017c | prsA | - | 100% (326) | ribose-phosphate pyrophosphokinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1045c | prsA | 0.0 | 100.00% (326) | ribose-phosphate pyrophosphokinase |
| M. gilvum PYR-GCK | Mflv_1943 | - | 1e-163 | 86.81% (326) | ribose-phosphate pyrophosphokinase |
| M. leprae Br4923 | MLBr_00248 | prsA | 1e-176 | 92.33% (326) | ribose-phosphate pyrophosphokinase |
| M. abscessus ATCC 19977 | MAB_1147c | - | 1e-162 | 85.67% (328) | ribose-phosphate pyrophosphokinase |
| M. marinum M | MMAR_4468 | prsA | 1e-180 | 95.71% (326) | ribose-phosphate pyrophosphokinase PrsA |
| M. avium 104 | MAV_1156 | - | 0.0 | 96.01% (326) | ribose-phosphate pyrophosphokinase |
| M. smegmatis MC2 155 | MSMEG_5427 | - | 1e-164 | 88.24% (323) | ribose-phosphate pyrophosphokinase |
| M. thermoresistible (build 8) | TH_0910 | prsA | 1e-167 | 87.93% (323) | PROBABLE RIBOSE-PHOSPHATE PYROPHOSPHOKINASE PRSA |
| M. ulcerans Agy99 | MUL_4638 | prsA | 1e-179 | 95.40% (326) | ribose-phosphate pyrophosphokinase |
| M. vanbaalenii PYR-1 | Mvan_4783 | - | 1e-164 | 87.42% (326) | ribose-phosphate pyrophosphokinase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1017c|M.tuberculosis_H37Rv -MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIF
Mb1045c|M.bovis_AF2122/97 -MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIF
MMAR_4468|M.marinum_M -MSHDWTDNRKNLMLFSGRAHPELAEQVAKELDVHVTAQTAREFANGEIF
MUL_4638|M.ulcerans_Agy99 -MSHDWTDNRKNLMLFSGRAHPELAEQVAKELDVHVTAQTAREFANGEIF
MAV_1156|M.avium_104 -MSHDWTDNRKNLMLFSGRAHPELAEQVAKELDVHVTAQTAREFANGEIF
MLBr_00248|M.leprae_Br4923 MLSHDWTDNRKNLMLFSGRAHPELAEQVAKELDMHVTTQDAREFANGEIF
TH_0910|M.thermoresistible__bu -VGTEWTENRKNLMFFSGRAHPELAEQVAKELDIHVTAQTARNFANGEIF
Mflv_1943|M.gilvum_PYR-GCK -MSHDWTDNRKNLMLFSGRAHPELAEQVAKELDVPVTAQTARVFANGEIF
Mvan_4783|M.vanbaalenii_PYR-1 -MSHDWTDNRKNLMLFSGRAHPELAEQVAKELDVPVTAQTARDFANGEIF
MSMEG_5427|M.smegmatis_MC2_155 -MATDWTDNRKNLMLFAGRAHPELADQVAKELDVAVTAQTARDFANGEIF
MAB_1147c|M.abscessus_ATCC_199 -MSTDWTDNRKNLMLFSGRAHPELAEQVAKELDVQVTAQTARDFANGEIF
:. :**:******:*:********:*******: **:* ** *******
Rv1017c|M.tuberculosis_H37Rv VRFHESVRGCDAFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPF
Mb1045c|M.bovis_AF2122/97 VRFHESVRGCDAFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPF
MMAR_4468|M.marinum_M VRFQESVRGCDAFVLQSCPAPVNTWLMEQLIMIDALKRGSAKRITAVMPF
MUL_4638|M.ulcerans_Agy99 VRFQESVRGCDAFVLQSCPAPVNTWLMEQLIMIDALKRGSAKRITAVMPF
MAV_1156|M.avium_104 VRFHESVRGCDAFVLQSAPAPVNSWLMEQLIMIDALKRGSAKRITAVMPF
MLBr_00248|M.leprae_Br4923 VRFHESVRGCDAFVLQSCPAPVNTWLMEQLIMIDALKRGSAKRITAVIPF
TH_0910|M.thermoresistible__bu VRYHESVRGCDAFVLQSHPAPLNEWIMEQLIMIDALKRGSAKRITAILPF
Mflv_1943|M.gilvum_PYR-GCK VRFDESVRGCDAFVLQSHPAPLNEWIMEQLLMIDALKRGSAKRITAILPF
Mvan_4783|M.vanbaalenii_PYR-1 VRFDESVRGCDAFVLQSHPAPLNTWLMEQLIMIDALKRGSAKRITAILPF
MSMEG_5427|M.smegmatis_MC2_155 VRFDESVRGCDAFVLQSHPAPLNQWLMEQLIMIDALKRGSAKRITAILPF
MAB_1147c|M.abscessus_ATCC_199 VRFEESVRGCDAFVLQSHPAPLNTWLMEQLIMIDALKRGSAKRITAILPF
**:.************* ***:* *:****:***************::**
Rv1017c|M.tuberculosis_H37Rv YPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGP
Mb1045c|M.bovis_AF2122/97 YPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGP
MMAR_4468|M.marinum_M YPYARQDKKHRGREPISARLVADLLKTAGADRIVTVDLHTDQIQGFFDGP
MUL_4638|M.ulcerans_Agy99 YPYARQDKKHRGREPISARLMADLLKTAGADRIVTVDLHTDQIQGFFDGP
MAV_1156|M.avium_104 YPYARQDKKHRGREPISARLVADLLKTAGADRIVTVDLHTDQIQGFFDGP
MLBr_00248|M.leprae_Br4923 YPYARQDKKHRGREPISARLVADLLKTAGADRIVTVDLHTDQIQGFFDGP
TH_0910|M.thermoresistible__bu YPYARQDKKHRGREPISARLIADLLKTAGADRIISVDLHTDQIQGFFDGP
Mflv_1943|M.gilvum_PYR-GCK YPYARQDKKHRGREPISARLIADLFKTAGADRIVTVDLHTDQIQGFFDGP
Mvan_4783|M.vanbaalenii_PYR-1 YPYARQDKKHRGREPISARLVADLYKTAGADRIVTVDLHTDQIQGFFDGP
MSMEG_5427|M.smegmatis_MC2_155 YPYARQDKKHRGREPISARLVADLLKTAGADRIVSVDLHTDQIQGFFDGP
MAB_1147c|M.abscessus_ATCC_199 YPYARQDKKHRGREPISARLVADLYKTAGADRIVTVDLHTDQIQGFFDGP
********************:*** ********::***************
Rv1017c|M.tuberculosis_H37Rv VDHMRGQNLLTGYIRDNYPD--GNMVVVSPDSGRVRIAEKWADALGGVPL
Mb1045c|M.bovis_AF2122/97 VDHMRGQNLLTGYIRDNYPD--GNMVVVSPDSGRVRIAEKWADALGGVPL
MMAR_4468|M.marinum_M VDHMRGQNLLTGYIRDNYSD--NNMVVVSPDSGRVRIAEKWADALGGVPL
MUL_4638|M.ulcerans_Agy99 VDHMRGQNLLTGYIRDNYSD--NNMVVVSPDSGRVRIAEKWADALGGVPL
MAV_1156|M.avium_104 VDHMRGQNLLTGYIRDNYPD--GNMVVVSPDSGRVRIAEKWADALGGVPL
MLBr_00248|M.leprae_Br4923 VDHMRGQNLLTGYIKNNYPD--TNMVVVSPDSGRVRIAEKWGDALGGVPL
TH_0910|M.thermoresistible__bu VDHMRAQNLLTGYIRDNYPC--DNMVVVSPDSGRVRVAEKWADSLGGTPL
Mflv_1943|M.gilvum_PYR-GCK VDHMRAQKLLTGYIADNYAD--HDMVVVSPDSGRVRVAEKWADSLGGVPL
Mvan_4783|M.vanbaalenii_PYR-1 VDHMRAQKLLTGYIAENYAD--HDMVVVSPDSGRVRVAEKWADALGGVPL
MSMEG_5427|M.smegmatis_MC2_155 VDHMRAQKLLTGYIGEHYAD--EDMVVVSPDSGRVRVAEKWADSLGGVPL
MAB_1147c|M.abscessus_ATCC_199 VDHMRAQSLLCGYIAEHYVSNGEDVVVVSPDSGRVRVAEKWADSLGGVPL
*****.*.** *** ::* ::***********:****.*:***.**
Rv1017c|M.tuberculosis_H37Rv AFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVALLH
Mb1045c|M.bovis_AF2122/97 AFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVALLH
MMAR_4468|M.marinum_M AFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVQLLR
MUL_4638|M.ulcerans_Agy99 AFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVQLLR
MAV_1156|M.avium_104 AFIHKTRDPRVPNQVVSNRVVGEVAGRTCVLIDDMIDTGGTIAGAVKLLR
MLBr_00248|M.leprae_Br4923 AFIHKTRDLRVPNQVVSNRVVGEVEGRTCVLIDDMIDTGGTVAGAVQLLR
TH_0910|M.thermoresistible__bu AFIHKTRDPRVPNEVVSNRVVGEVAGRCCVLTDDMIDTGGTIAGAVKLLK
Mflv_1943|M.gilvum_PYR-GCK AFIHKTRDPLVPNQVKSNRVVGDVRGKTCVITDDMIDTGGTIAGAVRLLK
Mvan_4783|M.vanbaalenii_PYR-1 AFIHKTRDPLVPNQVKSNRVVGDVKGRTCILTDDMIDTGGTIAGAVRLLK
MSMEG_5427|M.smegmatis_MC2_155 AFIHKTRDPLVPNQVKSNRVVGDVKGKTCILTDDMIDTGGTIAGAVNLLR
MAB_1147c|M.abscessus_ATCC_199 AFIHKTRDPRVPNQVKANRVVGDVTGKTCVITDDMIDTGGTIAGAVGLLH
******** ***:* :*****:* *: *:: *********:**** **:
Rv1017c|M.tuberculosis_H37Rv NDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLT
Mb1045c|M.bovis_AF2122/97 NDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLT
MMAR_4468|M.marinum_M NDGAGDVIIAATHGVLSDPAAERLAACGAREVIVTNTLPITEAKRFPQLT
MUL_4638|M.ulcerans_Agy99 NDGAGDVIIAATHGVLSDPAAERLAACGAREVIFTNTLPITEAKRFPQLT
MAV_1156|M.avium_104 DEGAGDVIIAATHGVLSDPAAERLASCGAREVIVTNTLPIGEEKRFPQLT
MLBr_00248|M.leprae_Br4923 NDGASDVIIAATHGVLSPPAAERLAQYGTREVIVTNTLPIGEEKRFPQLT
TH_0910|M.thermoresistible__bu EEGASEVIVAATHGVLSHPARDRLAECGAREVIVTNTLPIGEEKRFPQLT
Mflv_1943|M.gilvum_PYR-GCK EDGAGDVIIAATHGVLSDPARDRLAESGACEVIVTNTLPISEEKRFPQLT
Mvan_4783|M.vanbaalenii_PYR-1 QDGAADVVIAATHGVLSDPARERLAESGAREVIVTNTLPIGEDKMFPQLT
MSMEG_5427|M.smegmatis_MC2_155 EDGAKDVIIAATHGVLSDPAPQRLAECGAREVIVTNTLPITEDKRFPQLT
MAB_1147c|M.abscessus_ATCC_199 EAGAKDVVIAATHGVLSDPAAERLANCGAREVLVTNTLPIGEEKRFPQLT
: ** :*::******** ** :*** *: **:.****** * * *****
Rv1017c|M.tuberculosis_H37Rv VLSIAPLLASTIRAVFENGSVTGLFDGDA
Mb1045c|M.bovis_AF2122/97 VLSIAPLLASTIRAVFENGSVTGLFDGDA
MMAR_4468|M.marinum_M VLSIAPLLASTIRAVFENGSVTGLFDGDA
MUL_4638|M.ulcerans_Agy99 VLSIAPLLASTIRAVFENGSVTGLFDGDA
MAV_1156|M.avium_104 VLSIAPLLASTIRAVFENGSVTGLFDGDA
MLBr_00248|M.leprae_Br4923 VLSIAPLLASTIRAIFENGSVTGLFDGEA
TH_0910|M.thermoresistible__bu VLSIAPLLASTIRAVFENGSVTGLFDGDA
Mflv_1943|M.gilvum_PYR-GCK VLSIAPLLANTIRAVFDNGSVTSLFDGSA
Mvan_4783|M.vanbaalenii_PYR-1 VLSIAPLLANTIRAVFDNGSVTSLFDGSA
MSMEG_5427|M.smegmatis_MC2_155 VLSIAPLLANTIRAVFENGSVTGLFDGSA
MAB_1147c|M.abscessus_ATCC_199 VLSIAPLLASTIREVFENGSVTGLFDGNA
*********.*** :*:*****.****.*