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AMASKSALRDQLLAARRRVADDVRAAEARMLRGHLERMVTSDSTVCAYVPVGGEPGSIEMLDVLLRRAGR VLLPVARTAGGDLPLPLRWGEYRAGGLARARWGLLEPPEPWLPEAALAQASLVLVPALAVDRQGVRLGRG RGFYDRSLRCRDPHARLVAVVRTVELVDVLPSEPHDVPMTHALTPERGLIALPCGE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0992c | - | - | 100% (197) | hypothetical protein Rv0992c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1019c | - | 1e-110 | 99.49% (197) | hypothetical protein Mb1019c |
| M. gilvum PYR-GCK | Mflv_1896 | - | 2e-55 | 55.26% (190) | 5-formyltetrahydrofolate cyclo-ligase |
| M. leprae Br4923 | MLBr_00181 | - | 4e-78 | 72.59% (197) | hypothetical protein MLBr_00181 |
| M. abscessus ATCC 19977 | MAB_1085c | - | 9e-40 | 49.45% (182) | 5-formyltetrahydrofolate cyclo-ligase-like protein |
| M. marinum M | MMAR_4522 | - | 1e-70 | 65.98% (194) | hypothetical protein MMAR_4522 |
| M. avium 104 | MAV_1101 | - | 2e-83 | 78.76% (193) | 5,10-methenyltetrahydrofolate synthetase |
| M. smegmatis MC2 155 | MSMEG_5472 | - | 1e-58 | 58.73% (189) | 5,10-methenyltetrahydrofolate synthetase |
| M. thermoresistible (build 8) | TH_0941 | - | 2e-57 | 59.79% (189) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4694 | - | 9e-71 | 65.98% (194) | hypothetical protein MUL_4694 |
| M. vanbaalenii PYR-1 | Mvan_4834 | - | 7e-55 | 55.56% (189) | 5-formyltetrahydrofolate cyclo-ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0992c|M.tuberculosis_H37Rv ------MAMASKSALRDQLLAARRRVADDVRAAEARMLRGHLERMVTSDS
Mb1019c|M.bovis_AF2122/97 ------MAIASKSALRDQLLAARRRVADDVRAAEARMLRGHLERMVTSDS
MAV_1101|M.avium_104 ------MATTGKAALRERLLAARRRVADDVRAAEARMLREQLEFMVTSGS
MLBr_00181|M.leprae_Br4923 ------MVTASKATLRKQLLAARRSVADDIRAAETKMLSQHLELLVNSAS
MMAR_4522|M.marinum_M ------MTSVNKAAMRARLRQARRLVPDDVHAAEALLLDAHLAQVIDGGA
MUL_4694|M.ulcerans_Agy99 ------MTSVNKAAMRARLRQARRVVPDEVHAAEALLLDAHLAQVIDGGA
Mflv_1896|M.gilvum_PYR-GCK ------MAS-TKSQARAAILAVRRSLSEQTQERESTLLARHLAALIRPGT
Mvan_4834|M.vanbaalenii_PYR-1 ------MAL-TKAQVRAEILTARRSLTQQQHDREAAQLAAHLKALIAPGT
MSMEG_5472|M.smegmatis_MC2_155 ------MSPRSKSQLRTALLQNRRSVPEAVREGEAEALRGWLSGLKISGR
TH_0941|M.thermoresistible__bu VETSSTERQEAKQQLRRRLLAARRAVTAEVRAEEAAALARHVRRLVHADE
MAB_1085c|M.abscessus_ATCC_199 -------------------MQARRAISPAEREKQNDALAAHVLTAVSGLS
** :. : : * :
Rv0992c|M.tuberculosis_H37Rv TVCAYVPVGGEPGSIEMLDVLLRRAGRVLLPVARTAGGDLPLPLRWGEYR
Mb1019c|M.bovis_AF2122/97 TVCAYVPVGGEPGSIEMLDVLLRRAGRVLLPVARTAGGDLPLPLRWGEYR
MAV_1101|M.avium_104 TVCAYVPVGAEPGSVEMLDMLLRRAGRVLLPVARTAADDTPLPLCWGEYR
MLBr_00181|M.leprae_Br4923 TVCAYVPVGTEPGAIEMLDVLLRKTGRVLLPVARTGDDEIPLPLQWGEYR
MMAR_4522|M.marinum_M TVCGYVPVGTEPGSITMLDVLLQHGARVLLPVARTTDGDGPLPLMWGEYR
MUL_4694|M.ulcerans_Agy99 TVCGYVPVGTEPGSIPMLDVLLQHGARVLLPVARTTDGDGPLPLMWGEYR
Mflv_1896|M.gilvum_PYR-GCK TVCAHIPVGSEPGSLAIVDDIAGRAGSVLLPVARESDDGTPLPLQWGRYV
Mvan_4834|M.vanbaalenii_PYR-1 VVCAFIPVGSEPGSIAMVDDLVHRGVEVLLPVAREDIDGTPLPIRWGPHT
MSMEG_5472|M.smegmatis_MC2_155 TVCAYVPVGSEPGSIALLDTLLELGARVLLPVARNDAAGIPLPLQWGKYR
TH_0941|M.thermoresistible__bu TVCAYVPVGAEPGSLELVEALHAVAARVLLPVVRHDEDGAPAPLQWAEYR
MAB_1085c|M.abscessus_ATCC_199 VIAAYLPVGSEPGSVRMLDALLDRGVRILLPIARNDEAGIPMALRWGYYA
.:...:*** ***:: ::: : :***:.* * .: *. :
Rv0992c|M.tuberculosis_H37Rv AGGLARARWGLLEPPEPWLP-EAALAQASLVLVPALAVDRQGVRLGRGRG
Mb1019c|M.bovis_AF2122/97 AGGLARARWGLLEPPEPWLP-EAALAQASLVLVPALAVDRQGVRLGRGRG
MAV_1101|M.avium_104 PGTLTTGRWGLLEPAQPWLP-ASALADAALVLVPALAVDRRGVRLGRGRG
MLBr_00181|M.leprae_Br4923 PGGLTSGPWGLLEPPELRLP-ESALAEANLVLVPALAVDHHGVRLGRGGG
MMAR_4522|M.marinum_M PGELVRGRWGLLEPPAPWLP-ESAVGQAGLVLLPALAVDLEGVRLGKGLG
MUL_4694|M.ulcerans_Agy99 PGELVRGRWGLLEPPAPWLP-ESAVGQASLVLLPALAVDLEGVRLGKGLG
Mflv_1896|M.gilvum_PYR-GCK PGKLVAAPYGLREPEPPWLP-PETVATADVVLVPALAVDRAGSRLGRGAG
Mvan_4834|M.vanbaalenii_PYR-1 PGAVAKAPFGLREPHPPWLP-PEAVGRASVVLVPALAVDRSGARLGRGAG
MSMEG_5472|M.smegmatis_MC2_155 PGTLVAAEFGLREPPPPWLP-AETIGEADVILVPALAVDRSGARLGRGAG
TH_0941|M.thermoresistible__bu RDNLVRADYGLLEPAPPWLA-ADSVADAAVILVPALAVDRTGVRLGRGAG
MAB_1085c|M.abscessus_ATCC_199 REELVDAPFGLREPANPVAGSAAALAEAQLVLVPALAVDKQGNRLGRGAG
:. . :** ** ::. * ::*:****** * ***:* *
Rv0992c|M.tuberculosis_H37Rv FYDRSLRCRDPHARLVAVVRTVELVDVLPSEPHDVPMTHALTPERGLIAL
Mb1019c|M.bovis_AF2122/97 FYDRSLRCRDPHARLVAVVRTVELVDVLPSEPHDVPMTHALTPERGLIAL
MAV_1101|M.avium_104 FYDRSLGDRDPRARLVALVRDAELLDELPAEPHDVPMTHALTPQRGLVTL
MLBr_00181|M.leprae_Br4923 FYDRSLAGRDPHTLLIALVRDTELLNELPSEPHDVRMTHAVTPERGVIAL
MMAR_4522|M.marinum_M FYDRSLANRNPQARLLAIVRDEEVVDRLPSEPHDVRMTHAMTPQRGVISF
MUL_4694|M.ulcerans_Agy99 FYDRSLTNRNPQARLLAIVRDEEVVDRLPSEPHDVRMTHAITPQRGIISF
Mflv_1896|M.gilvum_PYR-GCK FYDRTLALVNPAALVIAVVRDDELVDHLPSEPHDVPMTHALTPGRGLVTL
Mvan_4834|M.vanbaalenii_PYR-1 FYDRTLPLADADAWLVAVVRDDEVVDHLPSEPHDVRMTHALTPQKGLVAL
MSMEG_5472|M.smegmatis_MC2_155 FYDRTLHHAAATAQVIAVVRDDELLDEIPAEPHDVAMTHVLTPKRGIVAL
TH_0941|M.thermoresistible__bu FYDRTLPSAAASALLVAVVRDDELVERLPAEPHDVVMTHALTPRRGLVPL
MAB_1085c|M.abscessus_ATCC_199 FYDRSLGFAARATPLVTPLFVGEIRDELPAGPHDVPITHAITAD-GLVTL
****:* : ::: : *: : :*: **** :**.:*. *::.:
Rv0992c|M.tuberculosis_H37Rv PCGE-----------
Mb1019c|M.bovis_AF2122/97 PCGE-----------
MAV_1101|M.avium_104 GAR------------
MLBr_00181|M.leprae_Br4923 PNSE-----------
MMAR_4522|M.marinum_M PHRE-----------
MUL_4694|M.ulcerans_Agy99 PHRE-----------
Mflv_1896|M.gilvum_PYR-GCK ASRRQPGNA------
Mvan_4834|M.vanbaalenii_PYR-1 GPEAGPSGRE-----
MSMEG_5472|M.smegmatis_MC2_155 R--------------
TH_0941|M.thermoresistible__bu SRDDSPARPGPRSAE
MAB_1085c|M.abscessus_ATCC_199 GAGTWQT--------