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VFTIGYSCASRGADSWLIRRCSVVQGCLDDPGATVEAIDDDGWPHTGDPCSPNSAASGKYGERPASVSTG DIHSLVIASDYRVPDPGRVWPLLQRNKSALADIGAHHVLIYASTHDSGRVLVMIGVRSREPIVELLRSRV FFDWFDAMGVDDIPAVFAGEIVDRFVAAPTTTQSTPRVPGVVVAAFASVNNVSNLTAEVRSAIARFTAAG IRKTWVFQAFDDAHEVLILQEFADEAGARQWIEHPDAAAEWMSGAGVGAYPPLFVGRFFDMMRIEALQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0852 | fadD16 | - | 100% (278) | POSSIBLE FATTY-ACID-CoA LIGASE FADD16 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0875 | fadD16 | 1e-163 | 100.00% (278) | fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_3323 | - | 7e-54 | 49.51% (204) | FadD16 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0596c | - | 7e-08 | 50.98% (51) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_4685 | fadD16 | 5e-90 | 76.33% (207) | fatty-acid-CoA ligase FadD16 |
| M. avium 104 | MAV_0972 | - | 1e-96 | 80.95% (210) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3566 | - | 1e-56 | 49.76% (209) | FadD16 protein |
| M. thermoresistible (build 8) | TH_0413 | - | 3e-59 | 50.47% (212) | FadD16 protein |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-05 | 62.50% (32) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_3044 | - | 7e-55 | 49.02% (204) | FadD16 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0852|M.tuberculosis_H37Rv --------------------------------------------------
Mb0875|M.bovis_AF2122/97 --------------------------------------------------
MAV_0972|M.avium_104 --------------------------------------------------
MMAR_4685|M.marinum_M --------------------------------------------------
Mflv_3323|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3044|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3566|M.smegmatis_MC2_155 --------------------------------------------------
TH_0413|M.thermoresistible__bu --------------------------------------------------
MAB_0596c|M.abscessus_ATCC_199 MESAQQTPGLTIPAALDQAAARFGERDALYADGSWLSFSELRARARRFAA
MUL_4126|M.ulcerans_Agy99 MTSDPR----TVPTALDRLVRRLPNHDALVTDERSFTVSELNDEVYRAAA
Rv0852|M.tuberculosis_H37Rv --------------------------------------------------
Mb0875|M.bovis_AF2122/97 --------------------------------------------------
MAV_0972|M.avium_104 --------------------------------------------------
MMAR_4685|M.marinum_M --------------------------------------------------
Mflv_3323|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3044|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3566|M.smegmatis_MC2_155 --------------------------------------------------
TH_0413|M.thermoresistible__bu --------------------------------------------------
MAB_0596c|M.abscessus_ATCC_199 ALIALGVEHGQRLAIWSPNSWHWPIACLGGQYAGAAVVPMNTRYTVDEAT
MUL_4126|M.ulcerans_Agy99 ALIELGVKPAARVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAA
Rv0852|M.tuberculosis_H37Rv -----MFTIGYSCASRGADSWLIRRCSVVQGCLDDPGATVEAIDDDGWPH
Mb0875|M.bovis_AF2122/97 -----MFTIGYSCASRGADSWLIRRCSVVQGCLDDPGATVEAIDDDGWPH
MAV_0972|M.avium_104 --------------------------------------------------
MMAR_4685|M.marinum_M --------------------------------------------------
Mflv_3323|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3044|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3566|M.smegmatis_MC2_155 --------------------------------------------------
TH_0413|M.thermoresistible__bu --------------------------------------------------
MAB_0596c|M.abscessus_ATCC_199 DILQRSHARVLVSVGKFLGTDRIEQLDTSSLPDLRHIVRVAVEDGDESGW
MUL_4126|M.ulcerans_Agy99 DILARTEAPVLFAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGT-W
Rv0852|M.tuberculosis_H37Rv TGDPCSPNSAASGKYGERPASVSTGDIHSLVIAS----------------
Mb0875|M.bovis_AF2122/97 TGDPCSPNSAASGKYGERPASVSTGDIHSLVIAS----------------
MAV_0972|M.avium_104 ---------------------MNNGDIHSMVIAS----------------
MMAR_4685|M.marinum_M ----------------------MTNDLHSMVIAS----------------
Mflv_3323|M.gilvum_PYR-GCK ---------------------MGEYDLHSFILAC----------------
Mvan_3044|M.vanbaalenii_PYR-1 ---------------------MGEYELHSFILAC----------------
MSMEG_3566|M.smegmatis_MC2_155 ---------------------MSEYDLHSLILAC----------------
TH_0413|M.thermoresistible__bu ---------------------MSEYDLDSLIVAC----------------
MAB_0596c|M.abscessus_ATCC_199 DAFVAHGDGVSDGDIDTRKAAVSSEDISDILFTSGTTGRSKGVLCMHRQP
MUL_4126|M.ulcerans_Agy99 DEFIET--GTDTGAVTARAAAVSPDDVSDILFTSGTTGRSKGVLCAHRQS
:: .::.:.
Rv0852|M.tuberculosis_H37Rv -----------DYRVPD----PGRVWPLLQRNKSALADIGAHHVLIYAST
Mb0875|M.bovis_AF2122/97 -----------DYRVPD----PGRVWPLLQRNKSALADIGAHHVLIYAST
MAV_0972|M.avium_104 -----------DYRVPD----PTRVWPLLERNKAALADIGAHHVLVYTST
MMAR_4685|M.marinum_M -----------DYRVSD----PTRVWPLLERNKSALADIGAHHVLVYAST
Mflv_3323|M.gilvum_PYR-GCK -----------DFKVDD----VDVMWKWLGKHRDGLHSIGAHHVVLYESI
Mvan_3044|M.vanbaalenii_PYR-1 -----------DFRVDD----VDRMWEWLKKHREGLESIGAHHVVLYESI
MSMEG_3566|M.smegmatis_MC2_155 -----------DFRVDD----VDDMWKWMNKHRDGLKSIGAHHVVLYKSI
TH_0413|M.thermoresistible__bu -----------DFRVED----VDGMWRWMQRQRDGLAEFGAHHVVVYSSL
MAB_0596c|M.abscessus_ATCC_199 LAASLAWATYGEFTENDRYLCVNPFFHNFGYKAGILACLQTGAALMPQLT
MUL_4126|M.ulcerans_Agy99 LSASASWAANGKITADDRHLCINPFFHNFGYKAGILACLQTGATLFPHLT
. * .: : : * : : .:.
Rv0852|M.tuberculosis_H37Rv HDSGRVLVMIG------VRSREPIVELLRSRVFFDWFDAM-------GVD
Mb0875|M.bovis_AF2122/97 HDSGRVLVMIG------VRSREPIVELLRSRVFFDWFDAM-------GVD
MAV_0972|M.avium_104 HDYGRVLVMIG------VHSREPIVELLRSRVFFDWFDEA-------GVD
MMAR_4685|M.marinum_M HDYGRVLVMIG------VHSREPVVELLRSRIFFDWFDAV-------GVD
Mflv_3323|M.gilvum_PYR-GCK WEPRRVLVTIG------IRQARSIREVLSSPAIFEWFDIS-------GAD
Mvan_3044|M.vanbaalenii_PYR-1 WEPRRVFVTIG------IRNARSIRDVLRSPAIFEWFDIS-------GAD
MSMEG_3566|M.smegmatis_MC2_155 WEPGRVLVTIG------IRQARSIRELLRSPEIFEWFDKS-------GVQ
TH_0413|M.thermoresistible__bu WEPGRILVTIG------IREPHSIRELLGSSRVFEWFDIA-------GVQ
MAB_0596c|M.abscessus_ATCC_199 FDPEKAMAAVQEHKITVLPGAPTIFQMLLDHPARKNYDLTSLRYSVTGAA
MUL_4126|M.ulcerans_Agy99 FDPLRTLQAIERHRITVLPGPPTIYQTLLDHPARDDYDLSSLRFAVTGAA
: : : : : .: : * . . :* *.
Rv0852|M.tuberculosis_H37Rv DIPAVFAGEIVDRFVAAPTTTQSTPRVPGVVVAAFASVNNVSNLTAEVR-
Mb0875|M.bovis_AF2122/97 DIPAVFAGEIVDRFVAAPTTTQSTPRVPGVVVAAFASVNNVSNLTAEVR-
MAV_0972|M.avium_104 DIPAVFAGEIVDRFITRPPTN---PRAPGVVVAAIASVNDVALLTSEVS-
MMAR_4685|M.marinum_M DIPAVFAGEIVDRFVVGASGS-GAAAAPGVVVAAIASVDDVATLIAEVA-
Mflv_3323|M.gilvum_PYR-GCK DIPPVFGGEVVEKIDLIGSGE--DNVVGRVVVGVMSSVQDVSTLMDKVH-
Mvan_3044|M.vanbaalenii_PYR-1 DIPPIFGGEVVEKIDLFGSGP--EGHVGRVVVGVMSSVADVSELMVKVH-
MSMEG_3566|M.smegmatis_MC2_155 DIPPIFGGEVVEKIDLGEPTP--ETHVAGVIVGAVAPVDDVSTLMRKVH-
TH_0413|M.thermoresistible__bu DIPPIFGGQVVERLDLFEPAP--ADAIANVIVGAMAAVDDVSNLMIKVR-
MAB_0596c|M.abscessus_ATCC_199 VVPVVLIERMQSELDFDLVLTAYGLTETQGFATICRSDDDAVTVATTCGR
MUL_4126|M.ulcerans_Agy99 TVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGR
:* :: .: ..: . . :. :
Rv0852|M.tuberculosis_H37Rv -------------------------------------SAIARFTAAGIRK
Mb0875|M.bovis_AF2122/97 -------------------------------------SAIARFTAAGIRK
MAV_0972|M.avium_104 -------------------------------------SAIDRFAQAGIRK
MMAR_4685|M.marinum_M -------------------------------------PAMERFVAAGIRK
Mflv_3323|M.gilvum_PYR-GCK -------------------------------------DGLDRFRQGGVRK
Mvan_3044|M.vanbaalenii_PYR-1 -------------------------------------DGLPRFKNGGVRK
MSMEG_3566|M.smegmatis_MC2_155 -------------------------------------DGLARFAGSGIRK
TH_0413|M.thermoresistible__bu -------------------------------------DALDRFTSAGVRR
MAB_0596c|M.abscessus_ATCC_199 PMLGYELRIDGAEKPGDEGEVLLRSANVMKGYLDDPKATAEAIDDDGWLH
MUL_4126|M.ulcerans_Agy99 PFADFELRIG-----PDTGEVLLRGPNVMLGYLDDPRATAAAIDADGWLH
: * :
Rv0852|M.tuberculosis_H37Rv TWVFQAFDDAHEVLILQEFADEAGARQWIEHPDAAAEWMSGAG------V
Mb0875|M.bovis_AF2122/97 TWVFQAFDDAHEVLILQEFADEAGARQWIEHPDAAAEWMSGAG------V
MAV_0972|M.avium_104 TWVFQAFDDDHEVLILQEFPDEDSAREWIDHPDAAAQWMSGAG------I
MMAR_4685|M.marinum_M TWVFQAFDDSHEVLILQEFPDEQRAREWIDHPDAAAQWLRGAG------I
Mflv_3323|M.gilvum_PYR-GCK IWVYRALDDGHEVLILQEIADEASARQWIEHPDAAAEWMTNAG------M
Mvan_3044|M.vanbaalenii_PYR-1 IWVYRAFDDGQEVLILQEIADEASARQWIEHPDAAAEWMTNAG------M
MSMEG_3566|M.smegmatis_MC2_155 IWVYRALDDGNEVMILQEIENEVSARQWISHPDAAAEWMTNAG------F
TH_0413|M.thermoresistible__bu IWVYRALDDGHEVMILQEIESEAAARQWIDHPDAAAEWMTKAG------L
MAB_0596c|M.abscessus_ATCC_199 TGDIGKLDARGNLTITDRLKDMYICGGFNVYPAEIEQVLMRLDGVADVAV
MUL_4126|M.ulcerans_Agy99 TGDIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAV
:* :: * :.: . . : :* : : . .
Rv0852|M.tuberculosis_H37Rv GAYPPLFVGRFFDMMRIEALQ-----------------------------
Mb0875|M.bovis_AF2122/97 GAYPPLFVGRFFDMMRIEALQ-----------------------------
MAV_0972|M.avium_104 GAYPPLFVGRFFDMMRIRAD------------------------------
MMAR_4685|M.marinum_M GAYPPLFVGRLSEMMRIDPQ------------------------------
Mflv_3323|M.gilvum_PYR-GCK GAYPTRFVGRLAHLMSVGEQV-----------------------------
Mvan_3044|M.vanbaalenii_PYR-1 GPYPSRFVGRFAHLMSVGEPG-----------------------------
MSMEG_3566|M.smegmatis_MC2_155 GPYPSLFVGKLAHIMTIEGQV-----------------------------
TH_0413|M.thermoresistible__bu GAYPSLFVGKFVHLMSVDESGNRMR-------------------------
MAB_0596c|M.abscessus_ATCC_199 IGVPDARLGEVGKAYIVLKPGATLNADSVIEYSAKHVANFKKPRFVDFLD
MUL_4126|M.ulcerans_Agy99 IGIPDHRLGEVGRAFIVARPGFNLDEKSVIDYTREHLANFKAPRSVRFVD
* :*.. :
Rv0852|M.tuberculosis_H37Rv ------------------------------
Mb0875|M.bovis_AF2122/97 ------------------------------
MAV_0972|M.avium_104 ------------------------------
MMAR_4685|M.marinum_M ------------------------------
Mflv_3323|M.gilvum_PYR-GCK ------------------------------
Mvan_3044|M.vanbaalenii_PYR-1 ------------------------------
MSMEG_3566|M.smegmatis_MC2_155 ------------------------------
TH_0413|M.thermoresistible__bu ------------------------------
MAB_0596c|M.abscessus_ATCC_199 ELPRNLGGKVVKPTLRAMHGEQRRAQKESS
MUL_4126|M.ulcerans_Agy99 TLPRNAGGKVVKPQLRELA-----------