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VMGGTYNEPNTNLTSPETTIRNLVHGIGFQRDVLGAEPATAWQLDVFGHDPQFPGLAADAGLTSSSWARG PHHQWGPAQGGVDRMQFCSEFEWIAPSGRGLLTHYMPAHYSAGWSMDSSTSLADAEAATYALFDQLKKVA LTRNVLLPVGTDYTPPNKWVTAIHRDWGARYTWPRFVCALPKEFFAAVRAELAKRGWVPSPQTRDMNPIY TGKDVSYIDTKQANRAAENAVLEAERFAVFAALLTGAEYPQAALAKAWVQLAYGAHHDAITGSESDQVYL DLLTGWRDAWELGRAARDNSLRLLSGAVAASHDRVVVWNPLTQRRTDIVTARVDPPLQAGVRVFDPDGAE VAALVEHDGRSVTWLACDVPSLGWRVYRLVPADEAPGWELVPGTDIANEHYRLAVDPERGGALSSLVQDG RQLIAAGRVANELALYEEYPSHPTQGEGPWHLLPTGPVVCSSACPAQVQAYRGPLGQRLVVRGRIGTLLR YTQTLTLWDGVDRVDCRTSIDEFTGEDRLLRLRWPCPVPGAMPISEVGDAVVGRGFALLHEGPESVDTAQ HPWTLDNPAYGWFGLSSAVRVRAGDGVRAVSVAEVVSPTETVSGPMARDLMVALVRAGVTATCSGADKPR YGHLDVDSNLPDARIALGGPDRNTFTKAVLAEAAPAYTAELQRQLAKTGTARVWVPAANPLARAWLPGAD LRAPCALPVLVIDGRDEKHLRAAVASLADDLADAEIVVHQRAAPQMEPFEDRTVALLNRGVPSFAVDSEG TLHTALMRSCTGWPSGVWIDQPRRTAPDGSNFQLQHWTHHFDYALVCGGGDWRRAGIPARSAQFSHPLLA VAPRRPQGELPAVGSLLHVEPADSVQLGALKAAGNPLAAGSARPVQPAAVALRLVQTTGADTPVTIGCEL GKVGALRPADLLETPLAMARARKSSIDLHGYQVATVLARLDVAADMANVLAADDVALAPHAETAQPQYAR YWLHNRGPAPLGGLPAVAHLHPRRVRGQPGDDVVLRLTAASDCTDSVLGGVVDVVCPLGWPATPARLPFT LGAGAHLQADIALSIPAGAPPGPYPVRAQLRVVDTAVPAAWRQVVEDVCVVTVGADSDLEELVYLVDGPA DIELAAGDRARLAVTIGSRAHAELALDAHSISPWGTWEWIGPPALGAVLPARGMAKLAFDVTPPAWLEPG QWWALVRVGCAGQLVYSPAVKVSVT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0648 | - | - | 100% (1215) | ALPHA-MANNOSIDASE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0667 | - | 0.0 | 99.84% (1215) | alpha-mannosidase |
| M. gilvum PYR-GCK | Mflv_5104 | - | 0.0 | 62.35% (1227) | glycoside hydrolase family protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4227c | - | 2e-18 | 26.22% (389) | putative glycosyl hydrolase |
| M. marinum M | MMAR_0985 | - | 0.0 | 76.88% (1224) | alpha-mannosidase |
| M. avium 104 | MAV_4512 | - | 0.0 | 74.67% (1224) | alpha-mannosidase |
| M. smegmatis MC2 155 | MSMEG_1361 | - | 0.0 | 66.48% (1229) | alpha-mannosidase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0737 | - | 0.0 | 76.03% (1185) | alpha-mannosidase |
| M. vanbaalenii PYR-1 | Mvan_1249 | - | 0.0 | 63.55% (1229) | glycoside hydrolase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5104|M.gilvum_PYR-GCK MDVLSAASTELFTGPPDAPMQVVRVTYRDCALPTPVRVEGAGLCTVGEPV
Mvan_1249|M.vanbaalenii_PYR-1 MDITSAESTELFTGPPDAPLQVVRVTYRGCSAPTRVRVEGPGLQTVADAV
MSMEG_1361|M.smegmatis_MC2_155 MHVTSAESTERYTGPAEEPRQLVAVTYRGCTQPSIITVEGDGIS--GSAR
Rv0648|M.tuberculosis_H37Rv --------------------------------------------------
Mb0667|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0985|M.marinum_M MQVVSAESTELFVGPPDAPLQLVRVRIAECTEPTSIRVDGAGLS--GQAL
MUL_0737|M.ulcerans_Agy99 MQVVSAESTELFVGPPDAPLQLVRVRIVECTEPTSIRVDGAGLS--GQAL
MAV_4512|M.avium_104 MEMTSALSTELFVGPPEAPLQLVRVAVAGCAEPTPVRVDGPGLR--GRAL
MAB_4227c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5104|M.gilvum_PYR-GCK AEPGGVPVEVSVQVADPAPGRRRDATVVAG----DTSAAFDFVDAEPGWT
Mvan_1249|M.vanbaalenii_PYR-1 AGPGGTLVEVAVRVGDPRPGQRRAARAVTG----DGTVDFDFIDAEPGWT
MSMEG_1361|M.smegmatis_MC2_155 IDPGDGVVEVPVDVERPVPGEIRRAHASG--------LGFDFTVAEPGWT
Rv0648|M.tuberculosis_H37Rv --------------------------------------------------
Mb0667|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0985|M.marinum_M AAVGAEILEVPVVLEDPVVGQRRDARVWAGPAGAACTFTFTFTVAEPGWT
MUL_0737|M.ulcerans_Agy99 AAVGAEILEVPVVLEDPVVGQRRDARVWAGSAGAACTFTFAFTVAEPGWT
MAV_4512|M.avium_104 AEAGAEVIEVAVTVDEPVVGQRRPARAGAG----EAELPFEFTVAEPGWT
MAB_4227c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5104|M.gilvum_PYR-GCK MFMVSHFHYDPVWWNTQAAYTSVWTENPPGRCRQTNGFELVSAHLDMARR
Mvan_1249|M.vanbaalenii_PYR-1 VFMVSHFHYDPVWWNTQAAYTSTWTEDPPGRCRQTNGFELVSAHLEMARR
MSMEG_1361|M.smegmatis_MC2_155 MYMISHFHYDPVWWNTQAAYTSVWTEDPPGQCRQTHGFDLVRAHLEMARR
Rv0648|M.tuberculosis_H37Rv --------------------------------------------------
Mb0667|M.bovis_AF2122/97 --------------------------------------------------
MMAR_0985|M.marinum_M MFMVSHFHYDPVWWNTQGAYTSQWHEDPPGRARQTNGFELVHAHLEMARR
MUL_0737|M.ulcerans_Agy99 MFMVSHFHYDPVWWNTQGAYTSQWHEDPPGRARQTNGFELVHAHLEMARR
MAV_4512|M.avium_104 MFMVSHFHYDPVWWNTQGAYTSEWTEDPPGRARQTNGFDLVHAHLEMARR
MAB_4227c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_5104|M.gilvum_PYR-GCK DPEYTFVLAEVDYLKPFWDTHPWERADLRRLIAEGRVEIMGGTYNEPNTN
Mvan_1249|M.vanbaalenii_PYR-1 EPEYKFVLAEVDYLKPFWDTHPEDRADLRRLISEGRVEIMGGTYNEPNTN
MSMEG_1361|M.smegmatis_MC2_155 EPEYKFVLAEVDYLKPYWDAHPEDRADLRRFIASGRVEIMGGTYNEPNTN
Rv0648|M.tuberculosis_H37Rv --------------------------------------MMGGTYNEPNTN
Mb0667|M.bovis_AF2122/97 --------------------------------------MMGGTYNEPNTN
MMAR_0985|M.marinum_M DPDYKFVLAEVDYLKPYWDTHPQDRADLRRFLAQGRVEVMGGTYNEPNTN
MUL_0737|M.ulcerans_Agy99 DPDYKFVLAEVDYLKPYWDTHPQDRADLRRFLAQGRVEVMGGTYNEPNTN
MAV_4512|M.avium_104 EPEYKFVLAEVDYLKPYWDTRPEDRADLRRFIAQGRVEVMGGTYNEPNTN
MAB_4227c|M.abscessus_ATCC_199 ----------------------------------------------MHDD
: :
Mflv_5104|M.gilvum_PYR-GCK LTSPETAIRNFVHGIGFQRDVLGAEPATAWQLDVFGHDPQFPGMAADAGL
Mvan_1249|M.vanbaalenii_PYR-1 LTGPETAIRNFVHGTGFQRDVLGAHPATAWQLDVFGHDPQFPAMAADAGL
MSMEG_1361|M.smegmatis_MC2_155 LTSPETAIRNFVHGMGFQRDILGATPATAWQLDVFGHDPQFPGMAADAGL
Rv0648|M.tuberculosis_H37Rv LTSPETTIRNLVHGIGFQRDVLGAEPATAWQLDVFGHDPQFPGLAADAGL
Mb0667|M.bovis_AF2122/97 LTSPETTIRNLVHGIGFQRDVLGAEPATAWQLDVFGHDPQFPGLAADAGL
MMAR_0985|M.marinum_M LTSPETTIRNLVHGIGFQRDVLGADPATAWQLDVFGHDPQFPGMAADAGL
MUL_0737|M.ulcerans_Agy99 LTSPETTIRNLVHGIGFQRDVLGADPATAWQLDVFGHDPQFPGMAADAGL
MAV_4512|M.avium_104 LTSPETTIRNLVHGMGFQRDVLGADPATAWQLDVFGHDPQFPGLAADAGL
MAB_4227c|M.abscessus_ATCC_199 RRIVEDRIRRFVD-----KRLNGAVYVDSAPLTVTAWAAPGEPVPFAEAV
* **.:*. : : ** . : * * . . :. .:
Mflv_5104|M.gilvum_PYR-GCK TSSSWARGPHHQWGPMAEVDGRAGDPARMQFASEFEWIAPSGRGLLTHYM
Mvan_1249|M.vanbaalenii_PYR-1 TSSSWARGPHHQWGPMASENGRVGDPTRMQFASEFEWMAPSGRGLLTHYM
MSMEG_1361|M.smegmatis_MC2_155 TSSSWARGPHHQWGPMQND----GDPERMQFCSEFEWIAPSGRGLLTHYM
Rv0648|M.tuberculosis_H37Rv TSSSWARGPHHQWGPAQGG------VDRMQFCSEFEWIAPSGRGLLTHYM
Mb0667|M.bovis_AF2122/97 TSSSWARGPHHQWGPAQGG------VDRMQFCSEFEWIAPSGRGLLTHYM
MMAR_0985|M.marinum_M TSSSWARGPHHQWGPAQGGRGE-G-VERMQFCSEFEWISPSGRGLLTHYM
MUL_0737|M.ulcerans_Agy99 TSSSWARGPHHQWGPAQGGRGE-G-VERMQFCSEFEWISPSGRGLLTHYM
MAV_4512|M.avium_104 TSSSWARGPHHQWGPATGDGSD-GGVERMQFSSEFEWIAPSGRGLLTHYM
MAB_4227c|M.abscessus_ATCC_199 GQDFHEITPGTPWGPPWST----------MWLHVTGTVPPSWRGRDEGSP
.. * *** : :.** **
Mflv_5104|M.gilvum_PYR-GCK PAHYAGGWWMDSSATLQEAEDATFELFTNLKKVALTRNVLLPVGTDYTPP
Mvan_1249|M.vanbaalenii_PYR-1 PAHYAAGWWMDSAPSLQEAEDATYELFTRMKTVALTRNVLLPVGTDYTPP
MSMEG_1361|M.smegmatis_MC2_155 PAHYSAGWWMDTSASLAEAEDATYTLFTKLKRVALTRNVLLPVGTDYTPP
Rv0648|M.tuberculosis_H37Rv PAHYSAGWSMDSSTSLADAEAATYALFDQLKKVALTRNVLLPVGTDYTPP
Mb0667|M.bovis_AF2122/97 PAHYSAGWSMDSSTSLADAEAATYALFDQLKKVALTRNVLLPVGTDYTPP
MMAR_0985|M.marinum_M PAHYSAGWWMDSSSSLAEAAAATYALFDELKRVALTRNVLLPVGTDYTPP
MUL_0737|M.ulcerans_Agy99 PAHYSAGWWMDSSSSLAEAAAATYALFDELKRVALTRNVLLPVGTDYTPP
MAV_4512|M.avium_104 PAHYSAGWWMDSAASLAEAQDATYALFVQLKKVALTRNVLLPVGTDYTPP
MAB_4227c|M.abscessus_ATCC_199 EMRVELGFTGGPG---FNAEGLVYRPDGTVVKGIAPRNAFVPIDNPDGPV
: *: ... :* .: : .**.::*:.. *
Mflv_5104|M.gilvum_PYR-GCK NKWVTDIHRDWNARYTWPRFVCALPREFFAAVRAELDARGGTASPQTRDM
Mvan_1249|M.vanbaalenii_PYR-1 NKWVTDIHRDWNARYTWPRFVCALPCEFFAAVRAELDAAGATASPQTRDM
MSMEG_1361|M.smegmatis_MC2_155 NKWVTEIHRDWNARYVWPKFVCALPSEFFAAVRAELDERGITPSPQTRDM
Rv0648|M.tuberculosis_H37Rv NKWVTAIHRDWGARYTWPRFVCALPKEFFAAVRAELAKRGWVPSPQTRDM
Mb0667|M.bovis_AF2122/97 NKWVTAIHRDWGARYTWPRFVCALPKEFFAAVRAELAKRGWVPLPQTRDM
MMAR_0985|M.marinum_M NKWVSEIHRDWAARYTWPRFVCGLPREFFAAVRAELADRGAVASPQTRDM
MUL_0737|M.ulcerans_Agy99 NKWVSEIHRDWAARYTWPRFVCGLPREFFAAVRAELADRGAVASPQTRDM
MAV_4512|M.avium_104 NKWVTAIHRDWAARYTWPRFVCALPREFFAAVRAELAQRGGAPSPQTRDM
MAB_4227c|M.abscessus_ATCC_199 DFYIEAAANPDIGKYFWS----PMPLGDKATSGEDALYRLGDVDLALRDL
: :: . .:* *. :* *: : **:
Mflv_5104|M.gilvum_PYR-GCK NPIYTGKDVSYIDTKQANRAAENATLEAEQFAVFAGALTGATYPDAALAK
Mvan_1249|M.vanbaalenii_PYR-1 NPIYTGKDVSYIDTKQANCAAEFAVLAGEQFAVFAALVTGATYPEAALAK
MSMEG_1361|M.smegmatis_MC2_155 NPIYTGKDVSYIDTKQANRAAEDAVLDAERFAVFAGLLGGADYPQAALAK
Rv0648|M.tuberculosis_H37Rv NPIYTGKDVSYIDTKQANRAAENAVLEAERFAVFAALLTGAEYPQAALAK
Mb0667|M.bovis_AF2122/97 NPIYTGKDVSYIDTKQANRAAENAVLEAERFAVFAALLTGAEYPQAALAK
MMAR_0985|M.marinum_M NPIYTGKDVSYIDTKQANRAAENAVLQAERFAVFAGVLCGAPYPQAALAK
MUL_0737|M.ulcerans_Agy99 NPIYTGKDVSYIDTKQANRAAENAVLQAERFAVFAGVLCGAPYPQAALAK
MAV_4512|M.avium_104 NPIYTGKDVSYIDTKQANRAAENTVLAAERFAVFAGLLAGAEYPQAALAK
MAB_4227c|M.abscessus_ATCC_199 NLWGLQQDIATLDG-------------------LMHTLPEDLPRRHEILR
* :*:: :* : : : :
Mflv_5104|M.gilvum_PYR-GCK AWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWQLGTTARDHALALLSD
Mvan_1249|M.vanbaalenii_PYR-1 AWVQLAYGAHHDGITGSESDQVYLDLLTGWRDAWQLGSATRDRALTLLSD
MSMEG_1361|M.smegmatis_MC2_155 AWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELGTTARSAALQLLSE
Rv0648|M.tuberculosis_H37Rv AWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELGRAARDNSLRLLSG
Mb0667|M.bovis_AF2122/97 AWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELGRAARDNSLRLLSG
MMAR_0985|M.marinum_M AWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWEIGRTVRDNSLQLLSR
MUL_0737|M.ulcerans_Agy99 AWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWEIGRTVRDNSLQLLSR
MAV_4512|M.avium_104 AWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELGRTARDDALALLSR
MAB_4227c|M.abscessus_ATCC_199 ALERMLDTVDPDDLAG--------TAAAGREQLADVLARPAYASAHRITA
* :: .. * ::* :* .: :: : ::
Mflv_5104|M.gilvum_PYR-GCK SVDAS---VVVWNPLSHNRCDMVTVRLEEPFTG--GMIDRDGNAVPVLTE
Mvan_1249|M.vanbaalenii_PYR-1 AVDAS---VVVWNPLSHNRSDVVTLHLDEPTSG--QLVDSEGRPVPVLTE
MSMEG_1361|M.smegmatis_MC2_155 AVDGS---IVVWNALAHSRTDVVTMHLDRPFPG--ALLGTDGNVVPVVVE
Rv0648|M.tuberculosis_H37Rv AVAASHDRVVVWNPLTQRRTDIVTARVDPPLQAGVRVFDPDGAEVAALVE
Mb0667|M.bovis_AF2122/97 AVAASHDRVVVWNPLTQRRTDIVTARVDPPLQAGVRVFDPDGAEVAALVE
MMAR_0985|M.marinum_M AVAGPGEAVVVWNPLTRRRTDIVTIELQRPLGAGVAVRGPDGAHTPAHVD
MUL_0737|M.ulcerans_Agy99 AVAGPGEAVVVWNPSTRRRTDIVTIELQRPLGAGVAVRGPDGAHTPAHVD
MAV_4512|M.avium_104 RVDG--ADVTVWNPLNGRRTDVVTARLDAAPGAGVRVLDADGAEVPAHVE
MAB_4227c|M.abscessus_ATCC_199 VGHAHIDSAWLWPVRETVR------KCARTFSNMVDLMDRHPDFR--FAC
. :* * . . : . . .
Mflv_5104|M.gilvum_PYR-GCK HGGRTVTWRARDVPSLGWQSYTFVPGDQGGGWEPSEGDEIANDRYRVRVD
Mvan_1249|M.vanbaalenii_PYR-1 HGGHTLTWIAHDVPSVGWRSYRMVPGHPPSSWEPLAGRQIGNDHYRLSVD
MSMEG_1361|M.smegmatis_MC2_155 HDGLTVSWLARDVPSLGWRSYRLADG-AGGGWSPVLGDAISNERYRLRVD
Rv0648|M.tuberculosis_H37Rv HDGRSVTWLACDVPSLGWRVYRLVPADEAPGWELVPGTDIANEHYRLAVD
Mb0667|M.bovis_AF2122/97 HDGRSVTWLACDVPSLGWRVYRLVPADEAPGWELVPGTDIANEHYRLAVD
MMAR_0985|M.marinum_M ADGRTVSWLASDVPSLGWKTYQLIPTDAATGWEPVTGTEIANEHYRLRVD
MUL_0737|M.ulcerans_Agy99 ADGRTVSWLASDVPSLGWKTYQLIPTDAATGWEPVTGTEIANEHYRLRVD
MAV_4512|M.avium_104 HGGRSVSWLARDVPSLGWRAYRLVAGEAASGWAPLRGSAIANEHYRLAVD
MAB_4227c|M.abscessus_ATCC_199 SSAQQYAWIKDKYPSL---FARIKEKVAAGQFIPVGG-------------
.. :* . **: : : *
Mflv_5104|M.gilvum_PYR-GCK PARGGGVCSLQADGRELVAEGRVGNELTVYAEYPAHPVAGEGPWHLLPRG
Mvan_1249|M.vanbaalenii_PYR-1 LARGGGVSSLVAGGRELIADGRVGNELAVYEEYPAHPTAGEGPWHLLPKG
MSMEG_1361|M.smegmatis_MC2_155 AARGGGVTSLVRDGRQLIAGGGVGNELAVYDEYSAHPQAGEGPWHLLPKG
Rv0648|M.tuberculosis_H37Rv PERGGALSSLVQDGRQLIAAGRVANELALYEEYPSHPTQGEGPWHLLPTG
Mb0667|M.bovis_AF2122/97 PERGGALSSLVQDGRQLIAAGRVANELALYEEYPSHPTQGEGPWHLLPTG
MMAR_0985|M.marinum_M PERGGGVESLVRDHRQLIADGRVGNELAVYQEYPSHPTQGEGPWHLLPNG
MUL_0737|M.ulcerans_Agy99 PERGGGVESLVRDHRQLIADGRVGNELAVYQEYPSHPTQGEGPWHLLPNG
MAV_4512|M.avium_104 AERGGTVASLIADGRELIGEGRVGNELAVYEEYPSHPSQGEGPWHLLPKG
MAB_4227c|M.abscessus_ATCC_199 --------MWVEADTNMPGAEAMARQFVMGKRFFLDEFGIDTPEVWLPDS
:: . :..::.: .: . : * ** .
Mflv_5104|M.gilvum_PYR-GCK PVTSSSQHPATAVRRYRSALGERLVIDGEIPGLFTYTQTLTLWHGVDRLD
Mvan_1249|M.vanbaalenii_PYR-1 PVLTSSQHPASSVQAYRSELGERIVVTGQIPGLLCYTQTLTLWQGIDRLD
MSMEG_1361|M.smegmatis_MC2_155 PVVCSSAAPADQVRCYRSAVGQRVVVRGRIGDLLRYTQTITLWNGLDRVD
Rv0648|M.tuberculosis_H37Rv PVVCSSAC-PAQVQAYRGPLGQRLVVRGRIGTLLRYTQTLTLWDGVDRVD
Mb0667|M.bovis_AF2122/97 PVVCSSAC-PAQVQAYRGPLGQRLVVRGRIGTLLRYTQTLTLWDGVDRVD
MMAR_0985|M.marinum_M PVVCSSES-AAEVRGYRCPIGQRLVVRGRIGTLLRYTQTLTLWRGVARVD
MUL_0737|M.ulcerans_Agy99 PVVCSSES-ADEVRGYRCPIGQRLVVRGRIGTLLRYTQTLTLWRGVARVD
MAV_4512|M.avium_104 PVVCSSAT-RARVRAYRGPLGERVVVHGRIGTLLRYTQTLTLWRGVARVD
MAB_4227c|M.abscessus_ATCC_199 FGYSAAMPQIVAASGSEYFLTQKISWN----SVNRMPHHTFIWEGIDGTG
:: . . : ::: : .: :* *: .
Mflv_5104|M.gilvum_PYR-GCK CRTTVDDFGGSDRLLRLRWPCPITGAMPVSEVGDAVIGRGFALLHD-PDS
Mvan_1249|M.vanbaalenii_PYR-1 CRTTVDDFLGEDRLLRLRWPCPIPGAMPVSEVGNAVIGRGFGLLHP-PGS
MSMEG_1361|M.smegmatis_MC2_155 CRTVVDEFTGEDRLLRLRWPCPVPGALPVSEVGDAVIGRGFGLMHD-GVS
Rv0648|M.tuberculosis_H37Rv CRTSIDEFTGEDRLLRLRWPCPVPGAMPISEVGDAVVGRGFALLH----E
Mb0667|M.bovis_AF2122/97 CRTSIDEFTGEDRLLRLRWPCPVPGAMPISEVGDAVVGRGFALLH----E
MMAR_0985|M.marinum_M CRTTIDDFSGNDQLVRLRWPCPVPGAMAVSEVGDAVVGRGFALLHPAGES
MUL_0737|M.ulcerans_Agy99 CRTTIDDFSGNDQLVRLRWPCPVPGAMAVSEVGDAVVGRGFALLHPVGES
MAV_4512|M.avium_104 CRTTIDEFTGADRLVRLRWPCPVPGAMPVSEVGDAVVGRGFALLH----D
MAB_4227c|M.abscessus_ATCC_199 VFTHFPPVDTYN-----------------SDLGGGDLAHAQRNYR-----
* . . : *::*.. :.:. :
Mflv_5104|M.gilvum_PYR-GCK -GESVDAAVHSHTLDNPAFGWFGLSSALRVRFRGDAVRAVSVAEVISPSG
Mvan_1249|M.vanbaalenii_PYR-1 -SDSVDTAVFPYTLDNPAHGWFGLSSAVRVRFRGGAVRAVSVAEVICSGG
MSMEG_1361|M.smegmatis_MC2_155 DGRAVDSARHPWTLDNPAYGWFGLSSAARIRIN-TGVRAVSVAEVVTADE
Rv0648|M.tuberculosis_H37Rv GPESVDTAQHPWTLDNPAYGWFGLSSAVRVRAG-DGVRAVSVAEVVSPTE
Mb0667|M.bovis_AF2122/97 GPESVDTAQHPWTLDNPAYGWFGLSSAVRVRAG-DGVRAVSVAEVVSPTE
MMAR_0985|M.marinum_M GARSVDTAQHLWTLDNPAYGWFGLSSAVRVRAGSDAVRAVSVAEVVSPSE
MUL_0737|M.ulcerans_Agy99 GARSVDTAQHLWTLDNPAYGWFGLFSAVRVRAGSDAVRAVSVAEVVSPSE
MAV_4512|M.avium_104 GDRALDTARHPWTLDNPAYGWFGLSSAARVRISDGGLRCLSVAEVVSPAE
MAB_4227c|M.abscessus_ATCC_199 -----DSGAGTMSLVPFGYGDGGGGPTREMLAYATRKRSLEGSPTVT---
*:. :* ..* * .: .: *.:. : .:
Mflv_5104|M.gilvum_PYR-GCK CEP--AVRKLVAALVRAGVTATCTAADAPRYG-DLSIDSNLPDLRISVGG
Mvan_1249|M.vanbaalenii_PYR-1 DE---TVGDLIAALGRAGVTATCTAADAPRYG-DLSVDSNLPDMRISIG-
MSMEG_1361|M.smegmatis_MC2_155 DPG--AARELMVALVRAGVTATCSSADKPRYG-DLTVDSNLPDTRFALGG
Rv0648|M.tuberculosis_H37Rv TVSGPMARDLMVALVRAGVTATCSGADKPRYG-HLDVDSNLPDARIALGG
Mb0667|M.bovis_AF2122/97 TVSGPMARDLMVALVRAGVTATCSGADKPRYG-HLDVDSNLPDARIALGG
MMAR_0985|M.marinum_M ATSGPLARELMVALVRAGVTATCSGADKPRYG-NLDVDSNLPDVRIALGG
MUL_0737|M.ulcerans_Agy99 ATSGPLARELMVALVRAGVTATCSGADKPRYG-NLDVDSNLPDVRIALGG
MAV_4512|M.avium_104 TTSGPLARELLVALVRAGVTATCSAADGPRYG-HLEVDSNLPDVRVALGG
MAB_4227c|M.abscessus_ATCC_199 ----------LGTPAQFFADARAEYANPPRWSGELYLELHRGTYTSQANT
: : : . * . *: **:. .* :: : .
Mflv_5104|M.gilvum_PYR-GCK VDENAFTATILTG--------------VVGDPPRWIPAARPLREVWVPGA
Mvan_1249|M.vanbaalenii_PYR-1 --VNSFTAQVLDG--------------AAGAARVWVPAARALREVWVPGA
MSMEG_1361|M.smegmatis_MC2_155 PDENPFTAAVLADADMAYTDELKRQLDAHGTARVWVPATAPLTEVWVPGA
Rv0648|M.tuberculosis_H37Rv PDRNTFTKAVLAEAAPAYTAELQRQLAKTGTARVWVPAANPLARAWLPGA
Mb0667|M.bovis_AF2122/97 PDRNTFTKAVLAEAAPAYTAELQRQLAKTGTARVWVPAANPLARAWLPGA
MMAR_0985|M.marinum_M PARNVFTKAVLADADPGYTAELERQLASGGRARVWVPAATSLASVWVPGA
MUL_0737|M.ulcerans_Agy99 PARNVFTKAVLADADPGYTAELERQLASGGRARVWVPAATSLASVWVPGA
MAV_4512|M.avium_104 PRRNAFTAAVLADADPAYADELRRQLAATGRARLWVPARAPLAAVWLPDA
MAB_4227c|M.abscessus_ATCC_199 KQGNRRSEHLLRE------------------AELWAATAAVRTGFEYPYA
* : :* . * .: * *
Mflv_5104|M.gilvum_PYR-GCK DLRDPSTLPVLVVGADGDV--DDAIAALIDDLADAQIRIDQDVDEH---F
Mvan_1249|M.vanbaalenii_PYR-1 DLRDPAALPVLVVGADGDT--AAAVSALIEDLADAEILVDQDVEAE---F
MSMEG_1361|M.smegmatis_MC2_155 DLRGVRAVGVLILAGD--------LDAVIEDLVDAEISVDQEILGDPGSF
Rv0648|M.tuberculosis_H37Rv DLRAPCALPVLVIDGRDEKHLRAAVASLADDLADAEIVVHQRAAPQMEPF
Mb0667|M.bovis_AF2122/97 DLRAPCALPVLVIDGRDEKHLRAAVASLADDLADAEIVVHQRAAPQMEPF
MMAR_0985|M.marinum_M DLRAPRALPVLVIDGRDDTDLAAAIAALVDDLADAEISVRQQAPPDMEPF
MUL_0737|M.ulcerans_Agy99 DLRAPRALPVLVIDGRDDTDLAAAIAALVDDLADAEISVRQQAPADMEPF
MAV_4512|M.avium_104 DLRDARALPVLVVDGRDERELRAAIAALVDDLGDAEITVTQQSPSRTADF
MAB_4227c|M.abscessus_ATCC_199 ELDEIWKLVLLQQFHDILPG-----SSIAWVHKDAERNYAAIANRLQAVI
:* : :* :: **: :
Mflv_5104|M.gilvum_PYR-GCK ESYTVAMINRGVPGFAVEADGTLNASLMRSCTGWPSGTWIDPPRRTAPDG
Mvan_1249|M.vanbaalenii_PYR-1 EPRTVAMINRGVPGFAVETDGTLHSSLMRSCTGWPSGTWIDPPRRTAPDG
MSMEG_1361|M.smegmatis_MC2_155 EDFTVAVLNRGVPGFAVDPDGTLHTSLMRSCTGWPSGTWIDPPRRTAPDG
Rv0648|M.tuberculosis_H37Rv EDRTVALLNRGVPSFAVDSEGTLHTALMRSCTGWPSGVWIDQPRRTAPDG
Mb0667|M.bovis_AF2122/97 EDRTVALLNRGVPSFAVDSEGTLHTALMRSCTGWPSGVWIDQPRRTAPDG
MMAR_0985|M.marinum_M EARTIALFNRGMPSFAVDSEGTLHTALMRSCTGWPSGVWIDEPRRTAPDG
MUL_0737|M.ulcerans_Agy99 EARTIALFNRGMPSFAVDSEGTLHTALMRSCTGWPSRVWIDEPRRTAPDG
MAV_4512|M.avium_104 DDYTVALLNLGVPSFAVDTAGTLHTALLRSCTGWPSGIWIDDPRRSAPDG
MAB_4227c|M.abscessus_ATCC_199 EAATGALAGTGARKLVFNAAPHARDGVPALGASVAD---RPRPVTPTPAP
: * *: . * :..:. . .: :. .. * .:*
Mflv_5104|M.gilvum_PYR-GCK SNFQLQHWTHAFDYAVVAGEGDWRDLRMPSRAAEFNQPLLPVPARHD--P
Mvan_1249|M.vanbaalenii_PYR-1 SNFALQHWTHTFDYALTAGDGDWRDSDIPSRSAEFNQPLMPVLTHHD--P
MSMEG_1361|M.smegmatis_MC2_155 SNFQLQHWTHTFDYAVVAGDGDWRDVGAPARAAEFNRPLVAVPSEDGRGE
Rv0648|M.tuberculosis_H37Rv SNFQLQHWTHHFDYALVCGGGDWRRAGIPARSAQFSHPLLAVAPRRP---
Mb0667|M.bovis_AF2122/97 SNFQLQHWTHHFDYALVCGGGDWRRAGIPARSAQFSHPLLAVAPRRP---
MMAR_0985|M.marinum_M SNFQLQHWTHDFDYALVCADGDWRRADIPARSAEFSQPLLAVTARDR---
MUL_0737|M.ulcerans_Agy99 SNFQLQHWTHDFDYALVCADGDWRRADIPARSAEFSQPLLAVTARDR---
MAV_4512|M.avium_104 SNFQLQHWTHHFDYALVSGPGDWRRAEIPARSAQFGNPLLAVAAGGG---
MAB_4227c|M.abscessus_ATCC_199 GGFRLDNGTIAATFDADGLLVSLVDAVSGREAMAAPGNLLQLHRDTP---
..* *:: * : . .: *: :
Mflv_5104|M.gilvum_PYR-GCK SRGG---LPSWGSLLDVAPERDVRVAALKAHGNPTARGSARRGGPHDGVT
Mvan_1249|M.vanbaalenii_PYR-1 SAGG---LPPWGSLIEVQPERTVRIGALKAAGNPSARGSAHRTDPADGII
MSMEG_1361|M.smegmatis_MC2_155 HPGG---LPPWGSLLEIEPAEVVQLGALKATGNPLASGSVHTVRPAEGIT
Rv0648|M.tuberculosis_H37Rv -QGE---LPAVGSLLHVEPADSVQLGALKAAGNPLAAGSARPVQPAA-VA
Mb0667|M.bovis_AF2122/97 -QGE---LPAVGSLLHVEPADSVQLGALKAAGNRLAAGSARPVQPAA-VA
MMAR_0985|M.marinum_M -AGK---LAQVGSLLEIEPAGSVQLGALKAAGNPLTAGSARSVDPAA-VT
MUL_0737|M.ulcerans_Agy99 -AGK---LAQVGSLLEIEPAGSVQLGALKAAGNPLTAGSARSVDPAA-VT
MAV_4512|M.avium_104 -AGTGPGLPPAGSLLRVQPAESVQLAALKPASNPLASGSAARPDPTA-VA
MAB_4227c|M.abscessus_ATCC_199 ----------------NQWDAWDIDGFYRNTVTDLAGADSVAIVDDALVI
. : . : .. :
Mflv_5104|M.gilvum_PYR-GCK LRVVETLGRDAEVSVQSGLRHIDAPQRLNLIEEPLRETRRT---AHLAGY
Mvan_1249|M.vanbaalenii_PYR-1 VRLVETLGRTTDVTVQSGLRDISDQVHVNLIEEPVPARAR-----ALHGY
MSMEG_1361|M.smegmatis_MC2_155 ARLVEITGAATEVKIRSGLRNASGAVPLNLLEEPVDGEPS-----HLHGY
Rv0648|M.tuberculosis_H37Rv LRLVQTTGADTPVTIGCELGKVGALRPADLLETPLAMARARKSSIDLHGY
Mb0667|M.bovis_AF2122/97 LRLVQTTGADTPVTIGCELGKVGALRPADLLETPLAMARARKSSIDLHGY
MMAR_0985|M.marinum_M LRLVETTGAAAPVTLRCELGELSELRMADLLEHPQRATPG----VNLHGF
MUL_0737|M.ulcerans_Agy99 LRLVETTGAAAPVTLRCELGELSELRMADLLEHPQRATPG----VNLHGF
MAV_4512|M.avium_104 LRLVETAGAGTRVAVDSDVATVSDLHAADLLEKPSRQVNS----IDLHGY
MAB_4227c|M.abscessus_ATCC_199 ARTFGNSRVMQRITLRQGSGALDIDIDIDWHESEKLLKLSFPFDVHADRS
* . : : . : *
Mflv_5104|M.gilvum_PYR-GCK EIATLRTELNFPRIRNAE----QMSLAPDAEPVQPLYARYWLHNRGPAPL
Mvan_1249|M.vanbaalenii_PYR-1 EIATLRTQLNLPRVSGAD----RQSLAPEAEPVQPLYARYWLHNRGPAPL
MSMEG_1361|M.smegmatis_MC2_155 QIATLSTRMNLPQVLRGE----HRQLAPEAEAAQPLYARYWLHNRGPAPL
Rv0648|M.tuberculosis_H37Rv QVATVLARLDVAADMANVLAADDVALAPHAETAQPQYARYWLHNRGPAPL
Mb0667|M.bovis_AF2122/97 QVATVLARLDVAADMANVLAADDVALAPHAETAQPQYARYWLHNRGPAPL
MMAR_0985|M.marinum_M HVATTLARLEMPAVLS-----CSDALAPQHEAAQPLYARYWLHNRGPAPL
MUL_0737|M.ulcerans_Agy99 HVATTLARLEMPAVLS-----CSDALAPQHEAAQPLYARYWLHNRGPAPL
MAV_4512|M.avium_104 QVATVLARLHAPAAPAG-----AAALAPHAEAAQPLYARYWLHNRGPAPL
MAB_4227c|M.abscessus_ATCC_199 ASETQFGHVYRPTHAN----------TSWDEAKFEICAHRWVHVGESG--
* .: . :. *. *: *:* ..
Mflv_5104|M.gilvum_PYR-GCK GGLPAVAHLHPHRLQAVGSEVVTLRLTVASDATDTALHGRVRLVAPPGWD
Mvan_1249|M.vanbaalenii_PYR-1 GGLPAAAHLHPHRLAAADGETVPFRLTAVSDATDAALHGRVRVEVPPGWR
MSMEG_1361|M.smegmatis_MC2_155 GGLPAVAYLHPENAAAEPDSQVALRLTVASDCTDAPLHGRVRVTVPPGWT
Rv0648|M.tuberculosis_H37Rv GGLPAVAHLHPRRVRGQPGDDVVLRLTAASDCTDSVLGGVVDVVCPLGWP
Mb0667|M.bovis_AF2122/97 GGLPAVAHLHPRRVRGQPGDDVVLRLTAASDCTDSVLGGVVDVVCPLGWP
MMAR_0985|M.marinum_M GGLPAVAYLHPEQVTAEPGSQVTLRLTTASDCTDSSLRGLIEVRFPDGWS
MUL_0737|M.ulcerans_Agy99 GGLPAVAYLHPEQVTAEPGSQVTLRLTTASDCTDSSLCGLIEVRFPDGWS
MAV_4512|M.avium_104 GGLPAVAHLHPARASADPDSRVTLRLSAASDCTDATLAGAVLLRCPDGWS
MAB_4227c|M.abscessus_ATCC_199 YGVAVVNNSTYGHDISRRGSTTVVRMSLLR----------APLFPDPDCD
*:... . . .. . .*:: : .
Mflv_5104|M.gilvum_PYR-GCK LGADELPFVVPPGEYLESTVEVRVPGDVMPGHYPVRAELALVGG---EIP
Mvan_1249|M.vanbaalenii_PYR-1 VDVTEMPFLLPPGEYLESTVEVVIPTGAAPGLYPVRAELAATGG---AIP
MSMEG_1361|M.smegmatis_MC2_155 VATTELSFVLPPDEYLETEVVIDIPPGAEPGLYPVRAELAVTGGDAAGVP
Rv0648|M.tuberculosis_H37Rv ATPARLPFTLGAGAHLQADIALSIPAGAPPGPYPVRAQLRVVDT---AVP
Mb0667|M.bovis_AF2122/97 ATPARLPFTLGAGAHLQADIALSIPAGAPPGPYPVRAQLRVVDT---AVP
MMAR_0985|M.marinum_M VAPRRLPFDLGAGEYVETNVMVRIPATAGPGLYPVRAQLSITEP---EVP
MUL_0737|M.ulcerans_Agy99 VAPRRLPFDLGAGEYVETNVMVRIPATAGPGLYPVRAQLSITEP---EVP
MAV_4512|M.avium_104 ADPAELPLRLCAGQHLQADIAVSVPARAAPGLYPVRAELRLTGE---HLP
MAB_4227c|M.abscessus_ATCC_199 QGRHRLQFSVRPGATIGDAVEEGYRRNLDPR--IVNGAVDAVEP---LIS
.: : : .. : : * *.. : . :.
Mflv_5104|M.gilvum_PYR-GCK AAWHQTVEDVAVISVG--GHADPLLHWVAEPQAVHVDAGQVASLGVTVGS
Mvan_1249|M.vanbaalenii_PYR-1 ASWHQTVEDVAVITVG--HHDDTLLRLVDEPQGIDIAAGDTAQLRVTVGT
MSMEG_1361|M.smegmatis_MC2_155 PSWRQCVEDVCVVTVG--EPGGHILRMLAEPQPVEVAVGDVARLSMTVGT
Rv0648|M.tuberculosis_H37Rv AAWRQVVEDVCVVTVGADSDLEELVYLVDGPADIELAAGDRARLAVTIGS
Mb0667|M.bovis_AF2122/97 AAWRQVVEDVCVVTVGADSDLEELVYLVDGPADIELAAGDRARLAVTIGS
MMAR_0985|M.marinum_M AAWRQMVEDVCVVAVG--TDLSQLVYLAEEPADLELAAGSSARHAVTVGS
MUL_0737|M.ulcerans_Agy99 AAWRQMVEDVCVVAVG--TDLSQLVYLAEEPAELELAAGSSARLAVTVGS
MAV_4512|M.avium_104 ASWRQGVEDVCVVAVG-DGERAPLIYLADEPAEVTLEPGEAADLTVAVGS
MAB_4227c|M.abscessus_ATCC_199 LDNPAVVVESVKLALD--GSGDVVVRLYESR-----GGRAEATLRSNFGH
* : :::. :: * .*
Mflv_5104|M.gilvum_PYR-GCK AAHADLTVEAHLISPWGTWEWLRPNIVGGALPARGGLALHFEVAPPVGTA
Mvan_1249|M.vanbaalenii_PYR-1 DSYADLTVEAHLISPWGTWEWLGPNIVGGVVPRRGTLALAFDVAPPVWAE
MSMEG_1361|M.smegmatis_MC2_155 DARADLSAEAHLISPWGTWEWMWPAAAGVDLPAGGSAEVVFDVAPPPWVA
Rv0648|M.tuberculosis_H37Rv RAHAELALDAHSISPWGTWEWIGPPALGAVLPARGMAKLAFDVTPPAWLE
Mb0667|M.bovis_AF2122/97 RAHAELALDAHSISPWGTWEWIGPPALGAVLPARGMAKLAFDVTPPAWLE
MMAR_0985|M.marinum_M RAQTDLTLEAHLISPWGTWEWMAPAAAGAVLPACGSAELVFDVAPPGWLA
MUL_0737|M.ulcerans_Agy99 RAQTDLTLEAHLISPWGTWEWMAPAAAGAALPVSGTSE------------
MAV_4512|M.avium_104 HARAELALEAHLISPWGTWDWMGPAAVGAVLPARGAVDLGFRLAPPAWLD
MAB_4227c|M.abscessus_ATCC_199 GQPIVTDLLERPIDESGTVSFNGDEIHLTLRPFKILTLRFPSVERRA---
: *. ** .: *
Mflv_5104|M.gilvum_PYR-GCK PGRWWALIRVACAGELLYSPAVPVVVRR
Mvan_1249|M.vanbaalenii_PYR-1 PGRWWALVRVACAGELVYSPAVPVVVR-
MSMEG_1361|M.smegmatis_MC2_155 PGEWWALIRVGCAGRLLYSPAVQVVVR-
Rv0648|M.tuberculosis_H37Rv PGQWWALVRVGCAGQLVYSPAVKVSVT-
Mb0667|M.bovis_AF2122/97 PGQWWALVRVGCAGQLVYSPAVKVSVT-
MMAR_0985|M.marinum_M PGQWWALVRVGCAGRLVYSPAVRVTVT-
MUL_0737|M.ulcerans_Agy99 -------------GR-------------
MAV_4512|M.avium_104 PGQWWALVRIGCAGELLYSPAVRVTVT-
MAB_4227c|M.abscessus_ATCC_199 ----------------------------