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MERMSEIPGPAPGPWWRSLQAASTRRALLLTALGGLLIAGVITALPKADPTGGLTANSISLGPRGNDTFD HAKSGDCLNWPDRTPDAAEVVDCAAEHRFEVAESVDMRTFPGSEYGPDAAPPSAARIQQISQEQCSAAVK RYLGARFDPNSRFTISMLWSGDKAWRQSGERRMLCGLQLPGPNNQQLAFQGKVAEIDQSKVWPAGTCLGI DPATNQPTDIPIDCAAPHAMEVTGAVNLAAKFPDVLPAEAEQDTFIKDECTKMTDAYLAPIKLRETTLTL IYSTVSLPSWAAGSRQVSCSIGATLGNGGWSTLLNSAKGPLMINGQPPVPPPDIPEERLTLPAIPVPDSS SDSSSDSSGSSSSSGSTYDESESPQQTVHGPQPTTAPTQTEEPAGQAPPGQGNTFLNGPPPAPPAPPAGP LPPAPPGAPLPPAPPAEVVPPPAEVLPPPPAPLPPPPPGI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5660 | - | - | 100% (460) | hypothetical protein Mvan_5660 |
| M. vanbaalenii PYR-1 | Mvan_2991 | - | 2e-13 | 36.07% (122) | hypothetical protein Mvan_2991 |
| M. vanbaalenii PYR-1 | Mvan_1068 | - | 1e-11 | 50.63% (79) | glycosyl transferase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3865 | - | 1e-158 | 63.53% (436) | hypothetical protein Mb3865 |
| M. gilvum PYR-GCK | Mflv_1149 | - | 0.0 | 80.09% (432) | hypothetical protein Mflv_1149 |
| M. tuberculosis H37Rv | Rv3835 | - | 1e-158 | 63.53% (436) | hypothetical protein Rv3835 |
| M. leprae Br4923 | MLBr_00081 | - | 1e-149 | 62.17% (423) | hypothetical protein MLBr_00081 |
| M. abscessus ATCC 19977 | MAB_0151c | - | 1e-135 | 53.12% (465) | hypothetical protein MAB_0151c |
| M. marinum M | MMAR_5387 | - | 1e-162 | 62.88% (466) | hypothetical protein MMAR_5387 |
| M. avium 104 | MAV_0192 | - | 1e-162 | 61.57% (471) | hypothetical protein MAV_0192 |
| M. smegmatis MC2 155 | MSMEG_6414 | - | 1e-178 | 66.18% (482) | hypothetical protein MSMEG_6414 |
| M. thermoresistible (build 8) | TH_0891 | - | 1e-168 | 79.32% (353) | PROBABLE CONSERVED MEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_5007 | - | 1e-158 | 62.69% (453) | hypothetical protein MUL_5007 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5660|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1149|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6414|M.smegmatis_MC2_155 --------------------------------------------------
TH_0891|M.thermoresistible__bu -----------------------------------------MLDAPGVDG
Mb3865|M.bovis_AF2122/97 --------------------------------------------------
Rv3835|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_5387|M.marinum_M --------------------------------------------------
MUL_5007|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00081|M.leprae_Br4923 --------------------------------------------------
MAV_0192|M.avium_104 --------------------------------------------------
MAB_0151c|M.abscessus_ATCC_199 MSDEAEPTPKVERDDSTPDEPTNDELGTDASADSPVESPDSATPPAEAPG
Mvan_5660|M.vanbaalenii_PYR-1 ----MERMSEIPGP---------APGPWW---------------------
Mflv_1149|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6414|M.smegmatis_MC2_155 ----MERMLEAPEHPDQLPDQRERKGRFW---------------------
TH_0891|M.thermoresistible__bu PGAEPDAGDPLTEDEPAKSGQAAERRRWWRLRSTRGSGPRGEPRWSPRQW
Mb3865|M.bovis_AF2122/97 -------MLDAPEQDPVDPGDP------ASPPHGEAEQPLPGPRWP----
Rv3835|M.tuberculosis_H37Rv -------MLDAPEQDPVDPGDP------ASPPHGEAEQPLPGPRWP----
MMAR_5387|M.marinum_M ----MELMLDAPEKELAPDSEPDPDAEADAETAAEAEQPSAGFRWP----
MUL_5007|M.ulcerans_Agy99 -------MLDAPEKELAPDSEPDPDAEADAETAAEAEQPSAGFRWP----
MLBr_00081|M.leprae_Br4923 -------MLDAPEEEPALADDL----------TGEDEQPPVEFQWP----
MAV_0192|M.avium_104 ----MEPMSQAPEKDLPEAGEA----------PAVETTAASAFLWP----
MAB_0151c|M.abscessus_ATCC_199 SASSAEGATESVDTEQAPATEILEYPDTDDSAVPVAEEPQQGAQESAKPQ
Mvan_5660|M.vanbaalenii_PYR-1 ---------RSLQAASTRRALLLTALGGLLIAGVITALPKAD-PTG-GLT
Mflv_1149|M.gilvum_PYR-GCK ---------------------------------MITALPDTD-PTG-GLT
MSMEG_6414|M.smegmatis_MC2_155 ---------ISLHAASTRRALLLTALGGLLIAGLITALPRSE-GANNTLS
TH_0891|M.thermoresistible__bu LQTPSAQRLRSLQATPTSRALLLTALGGLLIAGTVTAVPDQDRTAGRGLT
Mb3865|M.bovis_AF2122/97 ---------RALRASATRRALLLTALGGLLIAGLVTAIPAVGRAPERLAG
Rv3835|M.tuberculosis_H37Rv ---------RALRASATRRALLLTALGGLLIAGLVTAIPAVGRAPERLAG
MMAR_5387|M.marinum_M ---------RALQASATRRGLLLTALGGLLIAGLITAIPDVATGPGRLAG
MUL_5007|M.ulcerans_Agy99 ---------RALQASATRRGLLLTALGGLLIAGLITAIPDVATGPGRLGG
MLBr_00081|M.leprae_Br4923 ---------STLQARATRRGLLLTALGGLLIGGLVTAIPTVGTGSGLLAT
MAV_0192|M.avium_104 ---------RSLQARATRRALLLTALGGLLIAGLVTAIP-VGGGTG-SGR
MAB_0151c|M.abscessus_ATCC_199 WWAG---LKEGLKERSTHRALLLVTFGGLFIAGVTQALPDGWTSADRLVN
*:* .
Mvan_5660|M.vanbaalenii_PYR-1 AN----SISLGPRGNDTFDHAKSGDCLNWPD-RTPDAAEVVDCAAEHRFE
Mflv_1149|M.gilvum_PYR-GCK AN----SISLGPRGNDTFDHAKRGDCLTWPD-RTPDAAEIVDCAGEHRFE
MSMEG_6414|M.smegmatis_MC2_155 AG----AIALGPRGNETFNHVKDGDCLNWPG-RNPDAARIVDCGENHRFE
TH_0891|M.thermoresistible__bu SS----TISLGARGNATFDKASSGDCLTWPD-RTPDAAEIVDCTEEHRFE
Mb3865|M.bovis_AF2122/97 YIASNPVPSTGAKINASFNRVASGDCLMWPD-GTPESAAIVSCADEHRFE
Rv3835|M.tuberculosis_H37Rv YIASNPVPSTGAKINASFNRVASGDCLMWPD-GTPESAAIVSCADEHRFE
MMAR_5387|M.marinum_M YIDNNPVPSTGTKSNAAFNRATTGDCLMWPE-GTPEAATIVDCGDEHRFE
MUL_5007|M.ulcerans_Agy99 YIDNNPVPSTGTKSNAAFNRATTGDCLMWPE-GTPEAATIVDCGDEHRFE
MLBr_00081|M.leprae_Br4923 YIDSNPVPSTGAKSNVAFNRATNGDCLMWPD-STPHTAVIVNCADDHRFE
MAV_0192|M.avium_104 LLDASPVRSTGAKSDAAFNRAASGECLMWPD-TTPESAKIVNCGDDHKFE
MAB_0151c|M.abscessus_ATCC_199 KIDSNPVPSTGAPGNSTFNSAKAGECLNWPAPASTNDVNIVDCANDHRFE
: *. : :*: . *:** ** ... . :*.* :*:**
Mvan_5660|M.vanbaalenii_PYR-1 VAESVDMRTFPGSEYGPDAAPPSAARIQQISQEQCSAAVKRYLGARFDPN
Mflv_1149|M.gilvum_PYR-GCK VAESVDMGTFPGSEYGPDAAPPSAARIQQISQEQCSAAVKRYLGARFDPN
MSMEG_6414|M.smegmatis_MC2_155 VAAAIDMRTFPGSEYGPSAPPPSMDRIKQISQEQCTPALKSYLGPKFDPN
TH_0891|M.thermoresistible__bu VAEAIDMATFPGSEYGPDAAPPSPARIQQISQEQCESAVRNYLGPQYDPN
Mb3865|M.bovis_AF2122/97 VAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPN
Rv3835|M.tuberculosis_H37Rv VAESIDMRTFPGMEYGQNAAPPSPARIQQISEEQCEAAVRRYLGTKFDPN
MMAR_5387|M.marinum_M VAESIDMRTFPGSEYGPDAAPPSPARIQQISQEQCQAAVRRYLGAKFDPN
MUL_5007|M.ulcerans_Agy99 VAESIDMRTFPGSEYGPDASPPSPARIQQISQEQCRAAVRRYLGAEFDPN
MLBr_00081|M.leprae_Br4923 VAESIDMRTFPGSEYGPNAAPPSPARIQQISEEQCETAVRRYLGTKFDPN
MAV_0192|M.avium_104 VAESIDMRTFPGSEYGPNAAPPTPARIQQITQEQCEAAVRNYLGPKFDPN
MAB_0151c|M.abscessus_ATCC_199 IAESIDLRTFPGTEYGPNSKPPTVGRIQEISQEQCQVAINRYLGDRYDPN
:* ::*: **** *** .: **: **::*::*** *:. *** .:***
Mvan_5660|M.vanbaalenii_PYR-1 SRFTISMLWSGDKAWRQSGERRMLCGLQLPGPNNQQLAFQGKVAEIDQSK
Mflv_1149|M.gilvum_PYR-GCK SRFSVSMLWSGDKAWRQSGERRMLCGLQLPGPNNQQLAFTGRVADVDQSK
MSMEG_6414|M.smegmatis_MC2_155 GKFTIGLLWSGEKAWKQSGERRMLCGLQLLGPGDTQLEFTGKVADIDQSK
TH_0891|M.thermoresistible__bu SKFTISMLWSGDKAWTQSGERRVLCGLQLPGPNNQQLAFKGKVADIDQSK
Mb3865|M.bovis_AF2122/97 SKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSK
Rv3835|M.tuberculosis_H37Rv SKFTISMLWPGDRAWRQAGERRMLCGLQSPGPNNQQLAFKGKVADIDQSK
MMAR_5387|M.marinum_M SKFTTSMLWSGDRAWRQAGERRMLCGLQLPGPNNQQTAFKGKVADINQSK
MUL_5007|M.ulcerans_Agy99 SKFTTSMLWSGDRAWRQAGERRMLCGLQLPGPNNQQTAFKGKVADINQSK
MLBr_00081|M.leprae_Br4923 SKYTISMLWSGDRAWRQSGERRMLCGLQLPGVNNQQVAFKGKVANIDQSK
MAV_0192|M.avium_104 SKFTVSLLWPGDRAWRQGGDRRMLCGLQLPGANNQQQVFKGKVADVDQSK
MAB_0151c|M.abscessus_ATCC_199 SRFTMGMLWPGEKGWTEAGERRVLCGLQLPGADNQQQLFRGKVAEQDQSK
.::: .:**.*::.* :.*:**:***** * .: * * *:**: :***
Mvan_5660|M.vanbaalenii_PYR-1 VWPAGTCLGIDPATNQPTDIPIDCAAPHAMEVTGAVNLAAKFPDVLPAEA
Mflv_1149|M.gilvum_PYR-GCK VWPVGTCLGIDPATNQPTDIPVDCAAPHAMEVTGAVNLAAKFPAALPPEP
MSMEG_6414|M.smegmatis_MC2_155 VWPAGTCLGIDPATNQPTDVPVDCAAPHAMEVTGAVNLAEKFPGPLPAED
TH_0891|M.thermoresistible__bu VWPPGTCLGIDPATNQPTDIPVDCAAPHAMEVTGAVNLAERFPDGLPPDP
Mb3865|M.bovis_AF2122/97 VWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEP
Rv3835|M.tuberculosis_H37Rv VWPAGTCLGIDATTNQPIDVPVDCAAPHAMEVSGTVNLAERFPDALPSEP
MMAR_5387|M.marinum_M VWPAGTCLGIDSTTNQPIDIPVDCAAPHAMEVTGTVNLAEKFPDALPPEP
MUL_5007|M.ulcerans_Agy99 VWPAGTCLGIDSTTNQPIDIPVDCAAPHAMEVTGTVNLAEKFPDALPPEP
MLBr_00081|M.leprae_Br4923 VWPAGTCLSIDLTTNQPIDIPVDCVAPHAMEVTGTVNLADKFPNALPAAS
MAV_0192|M.avium_104 IWPTGTCLGIDSATNQPTDVPVDCAAPHAMEVTGTVNLAEKFPGALPAEP
MAB_0151c|M.abscessus_ATCC_199 VWPAGTCLGIDSTTNLPTELPVDCDKAHAMEITGTVSLAEQFPGSVPPEP
:** ****.** :** * ::*:** .****::*:*.** :** :*.
Mvan_5660|M.vanbaalenii_PYR-1 EQDTFIKDECTKMTDAYLA-PIKLRETTLTLIYSTVSLPSWAAGSRQVSC
Mflv_1149|M.gilvum_PYR-GCK EQDTFIKDECTKMTDAYLA-PIELRETTLTLVYSTVSLPSWAAGSRQVSC
MSMEG_6414|M.smegmatis_MC2_155 DQDEFIKDACTKQTDAYLA-PVQLRSTTLALSYSTISLPSWSAGSRQVSC
TH_0891|M.thermoresistible__bu EQDAFIKEECTRMTDEYLA-PIQLRDTTLTLIYSTISLPSWSAGSRQVSC
Mb3865|M.bovis_AF2122/97 EQDGFIKDACTRMTDAYLA-PLKLRTTTLTLIYPTLTLPSWSAGSRVVAC
Rv3835|M.tuberculosis_H37Rv EQDGFIKDACTRMTDAYLA-PLKLRTTTLTLIYPTLTLPSWSAGSRVVAC
MMAR_5387|M.marinum_M EQDGYIKDTCTRLTDAYLA-PIKLRTTTLTLIYPTLSLPSWSAGSREVAC
MUL_5007|M.ulcerans_Agy99 EQDGYIKDTCTRMTGAYLG-PIKLRTTTLTLIYPTLSLPSWSAGSREVAC
MLBr_00081|M.leprae_Br4923 EQDTFIKDACTRLTDIYLA-AIELRTTTLTLIYPTLSLSSWAAGSRKVAC
MAV_0192|M.avium_104 DQDAFIKDSCTKMTDAYLA-PVKLRTTTLTLIYPTVPLASWTAGSREVAC
MAB_0151c|M.abscessus_ATCC_199 DQDAFIKDNCTRLTNDYMGNPDGFRATTLTLSYNTITLPSWTAGSRQVSC
:** :**: **: *. *:. . :* ***:* * *:.*.**:**** *:*
Mvan_5660|M.vanbaalenii_PYR-1 SIGATLGNGGWSTLLNSAK-GPLMINGQPPVPPPDIPEERLTLPAIPVPD
Mflv_1149|M.gilvum_PYR-GCK SIGATLGNGGWSTLLNSAK-GPLMINGQPPVPPPDIPEERLSLPPIPVPD
MSMEG_6414|M.smegmatis_MC2_155 SIGATLGNGGWSTLVNTAK-GPLLINGQPPVAPPDIPAERLNLDPIPLPD
TH_0891|M.thermoresistible__bu SIGATLGNGGWSTLLNSAK-GPLLINGQPPVPPPEIPPERLSLPPIPLPQ
Mb3865|M.bovis_AF2122/97 SIGATLGNGGWATLVNSAK-GALLINGQPPVPPPDIPEERLNLPPIPLQL
Rv3835|M.tuberculosis_H37Rv SIGATLGNGGWATLVNSAK-GALLINGQPPVPPPDIPEERLNLPPIPLQL
MMAR_5387|M.marinum_M SIGATLGNGGWATLVNSAK-GELLINGQPPVPPPDIPEERLTLPPIPLQV
MUL_5007|M.ulcerans_Agy99 SIGATLSNGGWATLVNSAK-GELLINGQPPVPPPDIPEERLTLPPIPLQV
MLBr_00081|M.leprae_Br4923 SIGATMGNGGWATLVNSAK-GPLLINNQPPTPPPDIPEERLGMPPIPLHH
MAV_0192|M.avium_104 SIGATLGNGGWATLLNSAK-GQLLINGQPPVPPPDIPEERLSMPPIPLQA
MAB_0151c|M.abscessus_ATCC_199 NIGSTLGNGAWSTLVNSAKSGQLLINGQPPVPPPDIPADRLNMPPIPLST
.**:*:.**.*:**:*:** * *:**.***..**:** :** : .**:
Mvan_5660|M.vanbaalenii_PYR-1 ----SSSDSSSDSSGSSSSSGS--TYDESESPQQTVHGPQPTTAPTQTEE
Mflv_1149|M.gilvum_PYR-GCK ----SSSGSSSSSSSSGSSSSS--GSSDSSGSSDSSSGS-SQSEDQTVHG
MSMEG_6414|M.smegmatis_MC2_155 VAETSSGSSSSSSSGSSSSSGSSGTSGSSSSSSSGSSGSSGSSGSADQHL
TH_0891|M.thermoresistible__bu PPASSSSGSTSGSSGAGSSGAGSSGAGSGAGSSGAGAGSGSSNQTQQSHG
Mb3865|M.bovis_AF2122/97 P--------------------------TPRPAPP--AQQLPSTPPGTQHL
Rv3835|M.tuberculosis_H37Rv P--------------------------TPRPAPP--AQQLPSTPPGTQHL
MMAR_5387|M.marinum_M P--------------------------PAAPAPA--PRQTQTAPPSNQHL
MUL_5007|M.ulcerans_Agy99 P--------------------------PAAPA----PRQTQTAPPSNQHL
MLBr_00081|M.leprae_Br4923 L--------------------------QVPNSQS--NVPVNPIPPGNQQH
MAV_0192|M.avium_104 P--------------------------AQSPSTQSGSAAAPEMPPNNQHL
MAB_0151c|M.abscessus_ATCC_199 TP-------------------APTQQPTQTQQPTYTQQPTYTQQPTRTQQ
.
Mvan_5660|M.vanbaalenii_PYR-1 PAG-----QAPPGQG---NTFLNGPPPAPPAPPAGPLPP-APPGAPLPPA
Mflv_1149|M.gilvum_PYR-GCK PQA-----PAPAPTE---QPPVNPAPPPPAAAPADQLPPPGPLLLPPPPP
MSMEG_6414|M.smegmatis_MC2_155 PAQSTDTQQAPQSTDPAQQNTFNPPPPDAPAPPADQAAP-APAPAPAPAP
TH_0891|M.thermoresistible__bu QQH------APQQQE-------TGAPEXXXGTPPTTWWS-GCWRCSWPGR
Mb3865|M.bovis_AF2122/97 PAQ------QPVVT--------PTRPPESHAPASAAP-----AETQPPPP
Rv3835|M.tuberculosis_H37Rv PAQ------QPVVT--------PTRPPESHAPASAAP-----AETQPPPP
MMAR_5387|M.marinum_M PNQ------QPVVT--------PSRAPAAPATTTQATQPPPATQSQPPPA
MUL_5007|M.ulcerans_Agy99 PNQ------QPVVT--------PSRAPAAPATTTQATQPPPATQSQPPPA
MLBr_00081|M.leprae_Br4923 RKQ------QPIVT--------VPQSPASTAPAASVSP----AKHLPKAR
MAV_0192|M.avium_104 PGQ------QPVVTQ-------PPQAPPPPVDNGAPPP----ANPAPEAP
MAB_0151c|M.abscessus_ATCC_199 PTQQT--TQQPTRTSTAPTSSGAPSPPNQPGITIVTTLPPGAGPPPAPAG
* .
Mvan_5660|M.vanbaalenii_PYR-1 P---PAEVVPPPAEVLPPPPAPLPPPPPGI--
Mflv_1149|M.gilvum_PYR-GCK P---PAPVAGPPAEPLPPG----PPPPPGV--
MSMEG_6414|M.smegmatis_MC2_155 E---QAPPPPGPVDVPPPPGAP-VPPPPGP--
TH_0891|M.thermoresistible__bu R---WCRWP---------------IPIPG---
Mb3865|M.bovis_AF2122/97 D---AGAPPATQS-PEATPPGPAEPAPAG---
Rv3835|M.tuberculosis_H37Rv D---AGAPPATQS-PEATPPGPAEPAPAG---
MMAR_5387|M.marinum_M D---GGAPPPAQA-PEPEAPAPAEPAPGG---
MUL_5007|M.ulcerans_Agy99 D---GGAPPPAQA-PEPEAPAPAEPAPGG---
MLBr_00081|M.leprae_Br4923 H---TRQMSKRRGRPISPHPWAGRASPGGLAE
MAV_0192|M.avium_104 P---AAPPPPPPPAPEAP---PGGPPPAG---
MAB_0151c|M.abscessus_ATCC_199 PPMDGPPMEGPPMEGPPPGQAPAGAPPPGPA-
. *