For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TRFIDRVVIHARAGNGGNGCASVHREKFKPLGGPDGGNGGRGGSVVFVVDPQVHTLLDFHFHPHVVAPSG KQGAGSNRDGAAGTDLEVKVPDGTVVLDEHGQILADLVGEGTRFEAAAGGRGGLGNAALASRARKAPGFA LLGEKGESRDLTLELKTVADVGLVGFPSAGKSSLVSTISAAKPKIADYPFTTLAPNLGVVSAGEHTYTVA DVPGLIPGASQGRGLGLDFLRHIERCAVLVHVIDCATLEPGRDPISDIEALEAELAAYTPTLQGDSTLGD LAERPRAVVLNKIDVPEARELADFVREEIEAKFGWPVFEISTVAREGLRQLTFALWDMVAAYRAAQPAAV SRRPVIRPIPVDETAFSVVPDGQGGFIVKGTRPQRWVAQTNFDNDEAVGYLGDRLARLGVEDALLKLGAR PGCAVTIGDMTFDWEPQTPAGVDVPLTGRGTDVRLEQTDRVGADERKAARKARRQSGDE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3944 | obgE | - | 100% (480) | GTPase ObgE |
| M. vanbaalenii PYR-1 | Mvan_4625 | - | 9e-14 | 33.33% (129) | translation-associated GTPase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2467c | obgE | 0.0 | 81.34% (477) | GTPase ObgE |
| M. gilvum PYR-GCK | Mflv_2637 | obgE | 0.0 | 94.78% (479) | GTPase ObgE |
| M. tuberculosis H37Rv | Rv2440c | obgE | 0.0 | 81.34% (477) | GTPase ObgE |
| M. leprae Br4923 | MLBr_01465 | obgE | 0.0 | 78.24% (478) | GTPase ObgE |
| M. abscessus ATCC 19977 | MAB_1612 | obgE | 0.0 | 78.20% (477) | GTPase ObgE |
| M. marinum M | MMAR_3765 | obgE | 0.0 | 81.67% (480) | GTP1/OBGfamily GTP-binding protein Obg |
| M. avium 104 | MAV_1731 | obgE | 0.0 | 83.37% (481) | GTPase ObgE |
| M. smegmatis MC2 155 | MSMEG_4623 | obgE | 0.0 | 86.43% (479) | GTPase ObgE |
| M. thermoresistible (build 8) | TH_1177 | menG | 0.0 | 82.02% (445) | PROBABLE S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE |
| M. ulcerans Agy99 | MUL_3712 | obgE | 0.0 | 81.46% (480) | GTPase ObgE |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3944|M.vanbaalenii_PYR-1 -----------------------------------------MTRFIDRVV
Mflv_2637|M.gilvum_PYR-GCK -----------------------------------------MPRFIDRVV
MSMEG_4623|M.smegmatis_MC2_155 -----------------------------------------MPRFVDRVV
MLBr_01465|M.leprae_Br4923 -----------------------------------------MPRFVDRVV
MAV_1731|M.avium_104 -----------------------------------------MPRFVDRVV
Mb2467c|M.bovis_AF2122/97 -----------------------------------------MPRFVDRVV
Rv2440c|M.tuberculosis_H37Rv -----------------------------------------MPRFVDRVV
MMAR_3765|M.marinum_M -----------------------------------------MPRFVDRVV
MUL_3712|M.ulcerans_Agy99 -----------------------------------------MPRFVDRVV
MAB_1612|M.abscessus_ATCC_1997 -----------------------------------------MPRFVDRVV
TH_1177|M.thermoresistible__bu VIVEPRPTADLVDEIGPDVRSCDLQLQQYGGRAQFAGPISTVRCFQDNAL
: * *..:
Mvan_3944|M.vanbaalenii_PYR-1 IHARAGNGGNG-------------------CASVHREK------------
Mflv_2637|M.gilvum_PYR-GCK VHARAGNGGNG-------------------CASVHREK------------
MSMEG_4623|M.smegmatis_MC2_155 IHARAGNGGNG-------------------CASVHREK------------
MLBr_01465|M.leprae_Br4923 IHTWAGSGGNG-------------------CASIHRSK------------
MAV_1731|M.avium_104 IHARAGSGGNG-------------------CASVHREK------------
Mb2467c|M.bovis_AF2122/97 IHTRAGSGGNG-------------------CASVHREK------------
Rv2440c|M.tuberculosis_H37Rv IHTRAGSGGNG-------------------CASVHREK------------
MMAR_3765|M.marinum_M IHTRAGSGGNG-------------------CASVHREK------------
MUL_3712|M.ulcerans_Agy99 IHTRAGSGGNG-------------------CASVHREK------------
MAB_1612|M.abscessus_ATCC_1997 IHAKAGTGGHG-------------------CASVHREK------------
TH_1177|M.thermoresistible__bu LKSVLSEPGNGGVLVIDGDGSLHTALVGDVIAELARGNGWAGLIINGAVR
::: . *:* *.: * :
Mvan_3944|M.vanbaalenii_PYR-1 -----------FKPLGG---------------------------------
Mflv_2637|M.gilvum_PYR-GCK -----------FKPLGG---------------------------------
MSMEG_4623|M.smegmatis_MC2_155 -----------FKPLGG---------------------------------
MLBr_01465|M.leprae_Br4923 -----------FKPLGG---------------------------------
MAV_1731|M.avium_104 -----------FKPLGG---------------------------------
Mb2467c|M.bovis_AF2122/97 -----------FKPLGG---------------------------------
Rv2440c|M.tuberculosis_H37Rv -----------FKPLGG---------------------------------
MMAR_3765|M.marinum_M -----------FKPLGG---------------------------------
MUL_3712|M.ulcerans_Agy99 -----------FKPLGG---------------------------------
MAB_1612|M.abscessus_ATCC_1997 -----------FKPLGG---------------------------------
TH_1177|M.thermoresistible__bu DSATLRTLDIGIKALGTNPRKSTKTGAGQRDVAVEFGGVTFVPGEIAYAD
:*.**
Mvan_3944|M.vanbaalenii_PYR-1 ------PDGGNGGRGGSVVFVVDPQVHTLLDFHFHPHVVAPSGKQGAGSN
Mflv_2637|M.gilvum_PYR-GCK ------PDGGNGGRGGSVVFVVDPQVHTLLDFHFHPHVVAPSGKQGAGSN
MSMEG_4623|M.smegmatis_MC2_155 ------PDGGNGGRGGSVILVVDPQVHTLLDFHFHPHVVAPSGKPGAGSN
MLBr_01465|M.leprae_Br4923 ------PDGGNGGRGGSVVFVVDPHVHTLLDFHFRPHITAPSGKQGMGNN
MAV_1731|M.avium_104 ------PDGGNGGRGGSIVFVVDPQVHTLLDFHFHPHISAPSGKQGMGNN
Mb2467c|M.bovis_AF2122/97 ------PDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNN
Rv2440c|M.tuberculosis_H37Rv ------PDGGNGGRGGSIVFVVDPQVHTLLDFHFRPHLTAASGKHGMGNN
MMAR_3765|M.marinum_M ------PDGGNGGRGGSVVFVVDPQVHTLLDFHFRPHVTAASGKQGMGSN
MUL_3712|M.ulcerans_Agy99 ------PDGGNGGRGGSVVFVVDPQVHTLLDFHFRPHVTAASGKQGMGSN
MAB_1612|M.abscessus_ATCC_1997 ------PDGGNGGRGGSVILEVDPQVHTLLDFHFHPHLQAPNGTQGMGGH
TH_1177|M.thermoresistible__bu EDGIVVXXGGNGGRGGSVILVVDPQVHTLLDFHFHPHVVAPSGKPGQGSN
*********::: ***:*********:**: *..*. * *.:
Mvan_3944|M.vanbaalenii_PYR-1 RDGAAGTDLEVKVPDGTVVLDEHGQILADLVGEGTRFEAAAGGRGGLGNA
Mflv_2637|M.gilvum_PYR-GCK RDGAAGADLEVKVPDGTVVLDERGQILADLIGAGTRFEAAAGGRGGLGNA
MSMEG_4623|M.smegmatis_MC2_155 RDGAAGIDLEVRVPDGTVVLDENGRMLADLVGAGTRFEAAAGGRGGLGNA
MLBr_01465|M.leprae_Br4923 RDGAAGADLEVKVPDGTVVLDEDGRLLADLVGAGTRFQAAAGGRGGLGNA
MAV_1731|M.avium_104 RDGAAGADLEVKVPDGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNA
Mb2467c|M.bovis_AF2122/97 RDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNA
Rv2440c|M.tuberculosis_H37Rv RDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAGGRGGLGNA
MMAR_3765|M.marinum_M RDGAAGADLEVKVPDGTVVLDDNGRLLADLVGAGTRFEAAAGGRGGLGNA
MUL_3712|M.ulcerans_Agy99 RDGAAGADLEVKVPDGTVVLDDNGRLLADLVGAGTRFEAAAGGRGGLGNA
MAB_1612|M.abscessus_ATCC_1997 RNGANGDDLILKVPDGTVVLDDDGRILADLVGAGARFDAAAGGRGGLGNA
TH_1177|M.thermoresistible__bu RDGAAGADLEVKVPDGTVVLDEHGNLLADLTGAGTRFVAAEGGRGGLGNA
*:** * ** ::**:******: *.:**** * *:** ** *********
Mvan_3944|M.vanbaalenii_PYR-1 ALASRARKAPGFALLGEKGESRDLTLELKTVADVGLVGFPSAGKSSLVST
Mflv_2637|M.gilvum_PYR-GCK ALASRARKAPGFALLGEQGEVRELTLELKTVADVGLVGFPSAGKSSLVST
MSMEG_4623|M.smegmatis_MC2_155 ALASRARKAPGFALLGEKGQERDLTLELKTVADVGLIGFPSAGKSSLVST
MLBr_01465|M.leprae_Br4923 ALASRTRKVPGFALLGEQGESRDLTLELKSVADVGLIGFPSAGKSSLVSV
MAV_1731|M.avium_104 ALASRARKAPGFALLGEPGETRELTLELKTVADVGLIGFPSAGKSSLVSA
Mb2467c|M.bovis_AF2122/97 ALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSA
Rv2440c|M.tuberculosis_H37Rv ALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSA
MMAR_3765|M.marinum_M ALASRARKAPGFALLGEPGQARDLTLELKTVADVGLVGFPSAGKSSLVSV
MUL_3712|M.ulcerans_Agy99 ALASRARKAPGFALLGEPGQARDLTLELKTVADVGLVGFPSAGKSSLVSV
MAB_1612|M.abscessus_ATCC_1997 ALASRARKAPGFALLGEAGAEVDLTLELKTVADVGLVGFPSAGKSSLVSV
TH_1177|M.thermoresistible__bu ALASRARKAPGFALLGEPGQARDLVLELKTVADVGLIGYPSAGKSSLVST
*****.**.******** * :*.****:******:*:**********.
Mvan_3944|M.vanbaalenii_PYR-1 ISAAKPKIADYPFTTLAPNLGVVSAGEHTYTVADVPGLIPGASQGRGLGL
Mflv_2637|M.gilvum_PYR-GCK ISAAKPKIADYPFTTLAPNLGVVSAGEHTFTVADVPGLIPGASEGRGLGL
MSMEG_4623|M.smegmatis_MC2_155 ISAAKPKIADYPFTTLVPNLGVVSAGENTYTVADVPGLIPGASEGRGLGL
MLBr_01465|M.leprae_Br4923 ISAAKPKIADYPFTTLVPNLGVVSVGEHAFTVADVPGLIPGASAGRGLGL
MAV_1731|M.avium_104 ISAAKPKIADYPFTTLVPNLGVVSAGEHTFTVADVPGLIPGASAGRGLGL
Mb2467c|M.bovis_AF2122/97 ISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGL
Rv2440c|M.tuberculosis_H37Rv ISAAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGL
MMAR_3765|M.marinum_M ISAAKPKIADYPFTTLVPNLGVVAAGGHSFIVADVPGLIPGASQGRGLGL
MUL_3712|M.ulcerans_Agy99 ISAAKPKIADYPFTTLVPNLGVVAAGGHSFTVADVPGLIPGASQGRGLGL
MAB_1612|M.abscessus_ATCC_1997 LSAAKPKIADYPFTTLVPNLGVVTTGENSFVMADVPGLIPGAAEGRGLGL
TH_1177|M.thermoresistible__bu ISAAKPKIADYPFTTLTPNLGVVSAGDETFTVADVPGLIPGASEGRGLGL
:***************.******:.* .:: :**********: ******
Mvan_3944|M.vanbaalenii_PYR-1 DFLRHIERCAVLVHVIDCATLEPGRDPISDIEALEAELAAYTPTLQGDST
Mflv_2637|M.gilvum_PYR-GCK DFLRHIERCAVLVHVVDCATLEPGRDPISDIEALEAEIAAYTPTLQGDST
MSMEG_4623|M.smegmatis_MC2_155 DFLRHLERCAVLVHVVDCATMEPGRDPISDIEALEAELAAYTPTLQGDSA
MLBr_01465|M.leprae_Br4923 DFLRHIERCAVLVHVVDCTSVEPGRDPILDIAALEAELAAYTPTLQGDTT
MAV_1731|M.avium_104 DFLRHIERCAVLVHVIDCATADPGRDPISDIDALEAELAAYTPTLQGDVT
Mb2467c|M.bovis_AF2122/97 DFLRHIERCAVLVHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAA
Rv2440c|M.tuberculosis_H37Rv DFLRHIERCAVLVHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAA
MMAR_3765|M.marinum_M DFLRHIERCAVLVHVVDCATAEPGRDPISDIDALEAELAAYQPTLQGDAV
MUL_3712|M.ulcerans_Agy99 DFLRHIERCAVLVHVVNCATAEPGRDPISDIDALEAELAAYQPTLQGDAV
MAB_1612|M.abscessus_ATCC_1997 EFLRHIERCAVLVHVVDCATLEPGRDPVSDIDALENELARYQPTLQDDSV
TH_1177|M.thermoresistible__bu DFLRHIERCAVLVHVVDCATLELGRDPVSDIETLENELAAYTPTLQGDSE
:****:*********::*:: : ****: ** :** *:* * ****.*
Mvan_3944|M.vanbaalenii_PYR-1 LGDLAERPRAVVLNKIDVPEARELADFVREEIEAKFGWPVFEISTVAREG
Mflv_2637|M.gilvum_PYR-GCK LGDLAERPRAVVLNKIDVPEARELADFVREDVETRFGWPVFEISTVAREG
MSMEG_4623|M.smegmatis_MC2_155 LGDLASRPRAVVLNKIDVPDARELADFVRDEVAGRFGWPVYEISTVSRDG
MLBr_01465|M.leprae_Br4923 LGDFAERPRAVVLNKIDVPDARELAEFVCDNIAAERGWPVFSVSTVTREN
MAV_1731|M.avium_104 LGDLTERPRAVVLNKIDVPEARELAEFVRDEIA-ERGWPVFLVSTVAREG
Mb2467c|M.bovis_AF2122/97 LGDLAARPRAVVLNKIDVPEARELAEFVRDDIA-QRGWPVFCVSTATREN
Rv2440c|M.tuberculosis_H37Rv LGDLAARPRAVVLNKIDVPEARELAEFVRDDIA-QRGWPVFCVSTATREN
MMAR_3765|M.marinum_M LDDLAERPRAVVLNKIDVPEARELAEFVEDELA-QRGWPVFLVSTVTREN
MUL_3712|M.ulcerans_Agy99 LDDLAERPRAVVLNKIDVPEARELAEFVEDELA-QRGWPVFLVSTVTREN
MAB_1612|M.abscessus_ATCC_1997 LGDLADRPRAVVLNKVDVPEADELADFVTEEVS-QRGWPVFKVSTLTRDG
TH_1177|M.thermoresistible__bu LDDLTERPRAVVLNKIDVPEARELAEFVRDEIVQRFGWPVFLVSTATREG
*.*:: *********:***:* ***:** ::: . ****: :** :*:.
Mvan_3944|M.vanbaalenii_PYR-1 LRQLTFALWDMVAAYRAAQPAAVSRRPVIRPIPVDETAFSVVPDGQ--GG
Mflv_2637|M.gilvum_PYR-GCK LRPLIFALWDMVAAYRAAQPAAVPRRPVIRPIPVDETAFSVVPDGQ--GG
MSMEG_4623|M.smegmatis_MC2_155 LRPLIFALWEMVKKYRDAQPVAAPRRPIIRPIPVDESGFTISSDGE--GG
MLBr_01465|M.leprae_Br4923 LQSLIFGLWQMISAYHAARSEPAPGRSLIRPVPVDDSGFTVEPDGQ--GG
MAV_1731|M.avium_104 LQPLIFGLWQMISEYQSAQPEIVPRRSVIRPVPVDDSGFRVEPDPRQPGA
Mb2467c|M.bovis_AF2122/97 LQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGH--GG
Rv2440c|M.tuberculosis_H37Rv LQPLIFGLSQMISDYNAARPVAVPRRPVIRPIPVDDSGFTVEPDGH--GG
MMAR_3765|M.marinum_M LQPLIFGLWQMVSEYNAARPQAAPRRPVIRPVPVDDSGFDVQADGH--GG
MUL_3712|M.ulcerans_Agy99 LQPLIFGLWQMVSEYNAARPQAAPRRPVIRPVPVDDSGFDVQADGH--GG
MAB_1612|M.abscessus_ATCC_1997 LRPLTFALWEMIVAARAARPEPVKTRPVIRPIPVDESGFTVSADPQNPGG
TH_1177|M.thermoresistible__bu LRPLVFALWEMMKQYRASQPEVAPRRPVIRPVPVDETGFTVHPDGE--GG
*: * *.* :*: . ::. . *.:***:***::.* : .* . *.
Mvan_3944|M.vanbaalenii_PYR-1 FIVKGTRPQRWVAQTNFDNDEAVGYLGDRLARLGVEDALLKLGARPGCAV
Mflv_2637|M.gilvum_PYR-GCK FVVKGTRPQRWVAQTNFDNDEAVGYLGDRLARLGVEDELLKLGARPGCAV
MSMEG_4623|M.smegmatis_MC2_155 FIVRGTRPERWIAQTDFNNDEAVGYLGDRLARLGVEDELLKRGAKPGCAV
MLBr_01465|M.leprae_Br4923 FVVTGTRPERWIHQTNFDNAEAVGYLADRLARLGVEDELLRVGAQPGCTV
MAV_1731|M.avium_104 FVVSGARPERWVRQTNFDNDEAVGYLADRLARLGVEEELLRLGARPGCAV
Mb2467c|M.bovis_AF2122/97 FVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGARSGCAV
Rv2440c|M.tuberculosis_H37Rv FVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGARSGCAV
MMAR_3765|M.marinum_M FVVTGARPERWIGQTNFDNDEAVGYLADRLARLGVEEELLRLGAKPGCAV
MUL_3712|M.ulcerans_Agy99 FVVTGARPERWIGQTNFDNDEAVGYLADRLVRLGVEEELLRLGAKPGCAV
MAB_1612|M.abscessus_ATCC_1997 FVVRGVRPERWIRQTNFENDEAVGYLGDRLARLGVEDELLKLGAEPGCAV
TH_1177|M.thermoresistible__bu FVVRGVRPERWVTQTDFNNDEAVGYLADRLARLGVEEELLQLGAEPGCEV
*:* *.**:**: **:*:* ******.***.*****: **: **..** *
Mvan_3944|M.vanbaalenii_PYR-1 TIGDMTFDWEPQTPAGVD-VPLTGRGTDVRLEQTDRVGADERKAARKARR
Mflv_2637|M.gilvum_PYR-GCK TIGDMTFDWEPQTPAGVD-VHLSGRGTDVRLEQTDRVGADERKAARKARR
MSMEG_4623|M.smegmatis_MC2_155 TIGDVTFDWEPQTPAGVD-VTMTGRGTDIRLEQTDRVGAAERKAARRERR
MLBr_01465|M.leprae_Br4923 SIGGMTFDWEPQKPAGHP-VAMSGRGTDARLESTDPVGTAERKVARHQRH
MAV_1731|M.avium_104 TIGDMTFDWEPQTPAGQQ-VVLSGRGTDARLERTERVGAAERKAARRQRR
Mb2467c|M.bovis_AF2122/97 TIGEMTFDWEPQTPAGEP-VAMSGRGTDPRLDSNKRVGAAERKAARSRRR
Rv2440c|M.tuberculosis_H37Rv TIGEMTFDWEPQTPAGEP-VAMSGRGTDPRLDSNKRVGAAERKAARSRRR
MMAR_3765|M.marinum_M TIGEMTFDWEPQTPAGGH-VAMSGRGTDVRLERSDRVGAAERKAARRQRR
MUL_3712|M.ulcerans_Agy99 TIGEMTFDWEPQTPAGGH-VAMSGRGTDVRLERSDRVGAAERKAARRQRR
MAB_1612|M.abscessus_ATCC_1997 TIGDMTFDWEPQTPAGVD-VTMSGRGTDARIDKTDRVGAAERRQARRVRR
TH_1177|M.thermoresistible__bu TIGDMTFEWEPQTPAGVDDVPLSGRGTDARLEQSERVTAAERKAARRARR
:** :**:****.*** * ::***** *:: .. * : **: ** *:
Mvan_3944|M.vanbaalenii_PYR-1 QS----GDE-------
Mflv_2637|M.gilvum_PYR-GCK QSDD--GEE-------
MSMEG_4623|M.smegmatis_MC2_155 QPGESGGEDS------
MLBr_01465|M.leprae_Br4923 KHGG------------
MAV_1731|M.avium_104 TGDDAERGTTERGENT
Mb2467c|M.bovis_AF2122/97 EHGDG-----------
Rv2440c|M.tuberculosis_H37Rv EHGDG-----------
MMAR_3765|M.marinum_M ERDDD-----------
MUL_3712|M.ulcerans_Agy99 ERDDD-----------
MAB_1612|M.abscessus_ATCC_1997 GQVEPE----------
TH_1177|M.thermoresistible__bu EPGGEP----------