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MLDLKITGGTVVDGTGADRFRADIGVKDGRIVEVRRRDGDDPGLQTEAAHQIDATGRIVAPGFVDVHTHY DGQVSWDETLEPSSLHGVTTVVSGNCGVGFAPVRPGREQWLIELMEGVEDIPGSALAEGITWQWESFPEY LDAIEKRSLAIDYGTQIAHGAVRGYAMGERGANNEEATADDIAAMARIVREAIEAGALGFSTSRTEAHRA IDGQAVPGTYAAEAELFGLGRAMAAGGQAVFEVAPQGTAGESPADACMREMEWMAKLSDDISRPVSFTLI QASHAPDLWRQQLDRAEKAHENGIELYAQFAARPFGMLLGFPGYHAFTHRPTFRAVSAGSTRDELAARLA DPAVKAAILAEEDLPPTPGALLDGLFALAQYSTDRIYAIGDPPDYEPTPDKTVAAIAAARGQKPLETMYD LMLEADAGAMLMLPFFNYAEGDHRAIYEMMQSPAAVSGLSDGGAHCGLICDASYPTFLLTHWARDRHRGP KFSLEYVVRKQTLDTATLFGLSDRGVIAAGKKADINVIDMDALRLDVPRMVYDLPADGRRLLQGASGYDA TVVNGVVTRRHGVDTGARPGRLLRGVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3037 | - | - | 100% (587) | amidohydrolase 3 |
| M. vanbaalenii PYR-1 | Mvan_0767 | - | e-128 | 42.64% (584) | amidohydrolase 3 |
| M. vanbaalenii PYR-1 | Mvan_3035 | - | 6e-28 | 26.14% (547) | hypothetical protein Mvan_3035 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2937c | - | 2e-29 | 28.26% (559) | D-amino acid aminohydrolase |
| M. gilvum PYR-GCK | Mflv_3315 | - | 0.0 | 80.41% (587) | amidohydrolase 3 |
| M. tuberculosis H37Rv | Rv2913c | - | 2e-29 | 28.26% (559) | D-amino acid aminohydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2605c | - | 3e-30 | 26.55% (550) | hypothetical protein MAB_2605c |
| M. marinum M | MMAR_0213 | - | 0.0 | 72.06% (587) | D-amino acid aminohydrolase |
| M. avium 104 | MAV_5277 | - | 0.0 | 71.48% (589) | amidohydrolase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_0883 | - | 1e-131 | 44.39% (588) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_3974 | - | 0.0 | 72.06% (587) | PUTATIVE Amidohydrolase 3 |
| M. ulcerans Agy99 | MUL_1396 | - | 1e-119 | 41.32% (576) | D-amino acid aminohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3037|M.vanbaalenii_PYR-1 --------------MLDLKITGGTVVDGTGADRFRADIGVKDGRIVEVRR
Mflv_3315|M.gilvum_PYR-GCK --------------MLDLKITGGTVVDGTGAERFRADVGIKDGRIVEVRR
MMAR_0213|M.marinum_M --------------MFDLKIVGGTVVDGTGAARYRADIGIKDGKIVDVVR
MAV_5277|M.avium_104 --------------MFDLKITGGTVVDGTGAQRYRADVGIRDGKIVDVVR
TH_3974|M.thermoresistible__bu -------------MVFDLKITGGTVVDGTGADRFLGDIGIAGGTIVEVRR
MSMEG_0883|M.smegmatis_MC2_155 -----------MSHAFDLVIRGGTVVDGLGGEPVVGDVAVRDGVIVQVG-
MUL_1396|M.ulcerans_Agy99 -------------------------MTGWGGEPYVGDVAVRDGIIVAVGP
Mb2937c|M.bovis_AF2122/97 MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAA
Rv2913c|M.tuberculosis_H37Rv MLAWRQLNDLEETVTYDVIIRDGLWFDGTGNAPLTRTLGIRDGVVATVAA
MAB_2605c|M.abscessus_ATCC_199 MVPC-------SDAQFDTVIRNGRWFDGTGAPSAIRNIGIKDGHVAAVSA
. * * :.: .* :. *
Mvan_3037|M.vanbaalenii_PYR-1 R-DGDDPGLQ-TEAAHQIDATGRIVAPGFVDVHTHYDGQVSWDETLEPSS
Mflv_3315|M.gilvum_PYR-GCK R-SGDADGLQ-TQAAREIDATGRIVAPGFVDIHTHYDGQVSWDETLEPSS
MMAR_0213|M.marinum_M R-GTDDPGLG-GESAETIDATGQVVAPGFVDIHTHYDGQVSWDSTLEPSS
MAV_5277|M.avium_104 ADGSEAGGLATAEAAETIDATGKIVAPGFVDIHTHYDGQVSWDSLLEPSS
TH_3974|M.thermoresistible__bu R-GPGDPPLE-GAAAETLDATGTIVAPGFVDIHTHYDGQVSWDDLLEPSS
MSMEG_0883|M.smegmatis_MC2_155 -------EVAGTGA-REIDAAGLLVTPGFVDLHTHYDGQAIWSDRLNPSS
MUL_1396|M.ulcerans_Agy99 P----DDSVNGDAAGRVIDASGLLVTPGFVDLHTHYDGQSIWSDRLTPSS
Mb2937c|M.bovis_AF2122/97 G------ALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESV
Rv2913c|M.tuberculosis_H37Rv G------ALDETGCPEVVDAAGKWVVPGFIDVHTHYDAEVLLDPGLRESV
MAB_2605c|M.abscessus_ATCC_199 D------DLDETHCPNIIDASGKWVLPGLVDIHTHYDIEVLAAPALSESV
: . . :**:* * **::*:***** : * *
Mvan_3037|M.vanbaalenii_PYR-1 LHGVTTVVSGNCGVGFAPVRPGREQWLIELMEGVEDIPGSALAEGIT--W
Mflv_3315|M.gilvum_PYR-GCK LHGVTTVVSGNCGVGFAPVRPGREQWLIELMEGVEDIPGSALAEGIT--W
MMAR_0213|M.marinum_M GHGVTTVVTGNCGVGFAPVRPGSEDWLIRLMEGVEDIPGTALTEGIT--W
MAV_5277|M.avium_104 GHGVTTVVTGNCGVGFAPVRPGTEQWLIELMEGVEDIPGTALTEGIT--W
TH_3974|M.thermoresistible__bu GHGVTTVVMGNCGVGFAPVRPGREEWLIELMEGVEDIPGAALSEGIS--W
MSMEG_0883|M.smegmatis_MC2_155 SHGVTTAVMGNCGVGFAPCRAEDHDVLVDVMAGVEDIPGVVMTEGLN--W
MUL_1396|M.ulcerans_Agy99 AHGVTTVLMGNCGVGFAPCRQQDHDVLVDVMAGVEDIPGLVMTDGLP--W
Mb2937c|M.bovis_AF2122/97 RHGVTTVLLGNCSLSTVYANSED---AADLFSRVEAVPREFVLGALRDNQ
Rv2913c|M.tuberculosis_H37Rv RHGVTTVLLGNCSLSTVYANSED---AADLFSRVEAVPREFVLGALRDNQ
MAB_2605c|M.abscessus_ATCC_199 RHGVTTVLLGSCSLSVVHVDGVD---AGDIFGRVEAIPRDHVIQVVDRYK
*****.: *.*.:. . :: ** :* : :
Mvan_3037|M.vanbaalenii_PYR-1 QWESFPEYLDAIEKRSLAIDYGTQIAHGAVRGYAMGERGANNEE--ATAD
Mflv_3315|M.gilvum_PYR-GCK EWESFPEYLDAVGRRSLAIDYGTQIAHSAVRGYVMGERGARNED--ATAD
MMAR_0213|M.marinum_M GWESYPQYLDTIGKQKFSIDVGSQIAHGSVRAYTMGERGARNEP--ATAE
MAV_5277|M.avium_104 GWETYPEYLDAIGKQKFAIDVGSQVAHGAIRAYAMGERGARNEP--ATPD
TH_3974|M.thermoresistible__bu GWESYADYLDVIGGRKLAIDVGSQIAHGTVRAYAMGERGARNEP--ATPD
MSMEG_0883|M.smegmatis_MC2_155 HWETFPEYLDALAARRLDIDVAAYLPHSPLRVYVMGQRGADREP--ATAD
MUL_1396|M.ulcerans_Agy99 TWETFPEFMDALEAGARDIDVAAFLPHSPLRVYVMGQRGADREP--ATPE
Mb2937c|M.bovis_AF2122/97 TWSTPAEYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEA
Rv2913c|M.tuberculosis_H37Rv TWSTPAEYIEAIDALPLGPNVSSLLGHSDLRTAVLGLDRATDDTVRPTEA
MAB_2605c|M.abscessus_ATCC_199 TWTNAGQYVAALESLPLGPNVAAFLGHSDIRAAAMGLDRATRKDERPTAA
* . ::: .: : .: : *. :* .:* * . .*
Mvan_3037|M.vanbaalenii_PYR-1 DIAAMARIVREAIEAGALGFSTSRTEAHRAID----GQAVPGTYAAEAEL
Mflv_3315|M.gilvum_PYR-GCK DIDAMARLVREGIEAGALGFSTSRTEAHRALD----GTVMPGTYAVEAEL
MMAR_0213|M.marinum_M DIAAMGRLVTEAIEAGALGFSTSRTLAHRAMD----GEPVPGTFAAEDEL
MAV_5277|M.avium_104 DIEAMGRLVREAIEAGALGFSTSRTMGHRAMD----GEPVPGTFAAEEEL
TH_3974|M.thermoresistible__bu DIAAMSRIVREAAEAGALGFSSSRTLAHRAID----GEPVPGTFAAEDEL
MSMEG_0883|M.smegmatis_MC2_155 DLARMRALAREAIEAGALGFASSRLATHRTEG----GRQIPSFEAAYEEI
MUL_1396|M.ulcerans_Agy99 DLATMRALAKQAIEIGALGFASSRLTIHKTES----GSPIPSYDAARAEI
Mb2937c|M.bovis_AF2122/97 ELAKMAKLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRER
Rv2913c|M.tuberculosis_H37Rv ELAKMAKLLDEALEAGMLGMSGMDAAIDKLDGDRFRSRALPSTFATWRER
MAB_2605c|M.abscessus_ATCC_199 EQAQMDRWLTEALDAGFVGMSSQQLLFDKLDGDVCRSRTLPSTYAKPREL
: * :. : * :*:: .: . . :*. * *
Mvan_3037|M.vanbaalenii_PYR-1 FGLGRAMAAGGQAVFEVAPQGTAGESPADACMREMEWMAKLSDDISRPVS
Mflv_3315|M.gilvum_PYR-GCK LGLGRAMAAGGQAVFECSPAGTAGEN-DAASLTELDLLTRIAADIERPVS
MMAR_0213|M.marinum_M FGLGRAMAAGGQAVFELAPQGAAGED-IVGPRKELEWMRRLAGEIDRPVS
MAV_5277|M.avium_104 FGLGRAMAAGGQAVFELAPQGAAGED-IIGPKKELDWMRRLSGEIDRPVS
TH_3974|M.thermoresistible__bu FALGRALADGGGAVFELAPQGAAGED-IVAPGKELEWMRRLGAEIDCALS
MSMEG_0883|M.smegmatis_MC2_155 REIARGIADGGGGLIQFVPDIPAGGY-----QPVLQQVFDAAGETGLPVT
MUL_1396|M.ulcerans_Agy99 EEIAKGVVDGGGGLLQFVPDIPAGGY-----QPVLQTVFDVAEEVGLPVT
Mb2937c|M.bovis_AF2122/97 RKLISVLRHRGR-ILQSAPDVDNPVS-------ALLFFLASSRIFNRRKG
Rv2913c|M.tuberculosis_H37Rv RKLISVLRHRGR-ILQSAPDVDNPVS-------ALLFFLASSRIFNRRKG
MAB_2605c|M.abscessus_ATCC_199 RRLKAQLRQRNR-VLQSGPDIQNPLN-------VLSQAVQSLGILRRP--
: : . ::: * :
Mvan_3037|M.vanbaalenii_PYR-1 FTLIQASHAPDLWRQQLDRAEKAHENGI----ELYAQFAARPFGMLLGFP
Mflv_3315|M.gilvum_PYR-GCK FTLLQTGGAPTLYREQLDRIGKAHDNGV----PVYGQFAARPFGMLFGFA
MMAR_0213|M.marinum_M FALIQVDADPNLWREQLELSASAHAAGS----RLHPQIAARPFGMMIGFQ
MAV_5277|M.avium_104 FALIQVDADPNLWREMLDLSADAHAAGA----RLYPQIAARPFGMMIGFQ
TH_3974|M.thermoresistible__bu FALIQVDADPNLWREQLEISAAAHEAGS----RLYPQVAARPFGMLLGFP
MSMEG_0883|M.smegmatis_MC2_155 FSLLVLNAGEPLWREAMEMVEKANTSATSAAPRVTAQVFPRPIGLMIGLE
MUL_1396|M.ulcerans_Agy99 FSLVVGNVGEPSWPDAITMVENANKNAG-EGTRFTAQLLPRPIGLIIGLQ
Mb2937c|M.bovis_AF2122/97 VRMSMLVSADAKSMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSD
Rv2913c|M.tuberculosis_H37Rv VRMSMLVSADAKSMPLAVHVFGLGTRVLNKLLGSQVRFQHLPVPFELYSD
MAB_2605c|M.abscessus_ATCC_199 LSTSLLSAADIKANPYAIRAMGPVASLVNKLGG-NFRWQHLPVPFEVYAD
. : *. : .
Mvan_3037|M.vanbaalenii_PYR-1 G-YHAFTHRPTFRAVSAGSTRDELAARLADPAVKAAILAEEDLPPTPGAL
Mflv_3315|M.gilvum_PYR-GCK G-YHAFTHRPTYRALKAQLGPQELAEKLAEPAVRAAILAESDLPPQPVPL
MMAR_0213|M.marinum_M G-HHAFTHRPTYRRLKADCTRDELAQRLADPAVKAAILSEDDLPIDPNVL
MAV_5277|M.avium_104 G-HHGFSHRPTYRRLAAECSREELAQRLADPAVKAAILGEDDLPVDPTLL
TH_3974|M.thermoresistible__bu G-HHAFTHRPTYRRLAAECDREELAARLAEPAVRAAILAEDDLPPDPDVL
MSMEG_0883|M.smegmatis_MC2_155 LSANPFVLYPSYQEIAG-LPLPERVAQMRKPEVRERILSD-----KPGGT
MUL_1396|M.ulcerans_Agy99 LSANPFVLYPSYREIAH-LPLAERVAEMRKPDVRARILAD-----KPGG-
Mb2937c|M.bovis_AF2122/97 G-----IDLPVFEEFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRI
Rv2913c|M.tuberculosis_H37Rv G-----IDLPVFEEFGAGTAALHLRDQLQRNELLADRSYRRSFRREFDRI
MAB_2605c|M.abscessus_ATCC_199 G-----IDLVIFEEFGAGAAALHLRDEVERNELLRDEKYRRRFRKEYES-
:. . . .: :
Mvan_3037|M.vanbaalenii_PYR-1 LDGLFALAQYSTDRIYAIGDPPDYEPTPDKTVAAIAAARG-QKPLETMYD
Mflv_3315|M.gilvum_PYR-GCK FDSLFALVQNALDRIYPMGNPPDYEPTPDMTVAAIAERAG-ADPLATLYD
MMAR_0213|M.marinum_M FDGMSAFVQYSLGRVYALGDPPDYEPTRDRTVAAIAQARG-QDPLATLYD
MAV_5277|M.avium_104 FDGMFALVQHSLHRLYALGDPPDYEPTPDRTVAAIAEARG-EDPLATLYD
TH_3974|M.thermoresistible__bu FDGMFAFAQHAVDRLYPLGDPPDYEPTPDRTVTAIAAERG-VDPLTAMYD
MSMEG_0883|M.smegmatis_MC2_155 PANPLVYLAQAWDWIFPLGPDANYEPDRSQSIAARARAHG-VTPLEEAYD
MUL_1396|M.ulcerans_Agy99 -GHPILYVAQAWDWIFPLTEDPNYEPAAADSIGARARARG-VSPMEEAYD
Mb2937c|M.bovis_AF2122/97 KLGPSLWHRDFHDAVIVECPD---KSLIGKSFGAIADERG-LHPLDAFLD
Rv2913c|M.tuberculosis_H37Rv KLGPSLWHRDFHDAVIVECPD---KSLIGKSFGAIADERG-LHPLDAFLD
MAB_2605c|M.abscessus_ATCC_199 KFGVRVWHRDFFDAEIVSCPD---KSVLGKSFGQVGMDRGGLHPVDAFLD
:. :. . * *: *
Mvan_3037|M.vanbaalenii_PYR-1 LMLEADAGAMLMLPFFNYAEGDHRAIYEMMQSPAAVSGLSDGGAHCGLIC
Mflv_3315|M.gilvum_PYR-GCK LMLEDDATAMLMLPFFNYADGNHDAIHEMMSHPGTVSGLSDGGAHCGLIC
MMAR_0213|M.marinum_M LMLESNASAMLMLPLFNYADGNCDAIREMMLHPAGVLGLSDGGAHCGMIC
MAV_5277|M.avium_104 LMLDADATNMLMLPLFNYADGNCDAIREMLLHPAGVLGLSDGGAHCGMIC
TH_3974|M.thermoresistible__bu LMLENGAGAMLLLPLYNYADGNHDAIREMLTHPAGVLGLSDGGAHCSMIC
MSMEG_0883|M.smegmatis_MC2_155 LLLEDDGHAILLGALANFYDNSLDTVGDLMTREDVVLGLGDGGAHYGMIC
MUL_1396|M.ulcerans_Agy99 RLLDDDGHAMLLVATSNMENNSLDTVGKLLHREDVVLGLGDGGAHYGMIC
Mb2937c|M.bovis_AF2122/97 VLVDNGERNVRWTTIVAN--HRPNQLNKLAAEPSVHMGFSDAGAHLRNMA
Rv2913c|M.tuberculosis_H37Rv VLVDNGERNVRWTTIVAN--HRPNQLNKLAAEPSVHMGFSDAGAHLRNMA
MAB_2605c|M.abscessus_ATCC_199 LVLEHG-TAMRWRTTISN--HRPEVLKQLAQDPGVQIGFSDAGAHLRNMA
::: . : . : .: *:.*.*** :.
Mvan_3037|M.vanbaalenii_PYR-1 DASYPTFLLTHWARDRHRGP-KFSLEYVVRKQTLDTATLFGLSDRGVIAA
Mflv_3315|M.gilvum_PYR-GCK DASYPTFLLTHWARDRHRGP-KFSLEAVIRKQTLDTATLFGLSDRGVIAP
MMAR_0213|M.marinum_M DASYPTFLLTHWARDRKRGE-KLPLEYVIRKQARDTAHLFGLTDRGTIEP
MAV_5277|M.avium_104 DASYPTFLLTHWARDRSRGD-KLALEYVIRKQSRDTAHLFGLTDRGTIEP
TH_3974|M.thermoresistible__bu DASYPTFLLTHWARDRSRGD-RLPLEYVIRKQAHDTAQLFGLTDRGTIAV
MSMEG_0883|M.smegmatis_MC2_155 DSSFPTYLLAHWARDRAEG--RMSVPQAVRQLTSVPAQVAGLADRGRIAV
MUL_1396|M.ulcerans_Agy99 DASYSTYCLTHWARDRASG--RFSVAEAVRELTSVPARVAGLGDRGRIAV
Mb2937c|M.bovis_AF2122/97 FYNFGLRLLKRARDADRAGQPFLSIERAVYRLTGELAEWFGIG-AGTLRQ
Rv2913c|M.tuberculosis_H37Rv FYNFGLRLLKRARDADRAGQPFLSIERAVYRLTGELAEWFGIG-AGTLRQ
MAB_2605c|M.abscessus_ATCC_199 FYNFGLRLLRHVREAQQAGRPFMTVEQAVHRLTGELADWYQID-AGHLRI
.: * : * :.: .: . : * : * :
Mvan_3037|M.vanbaalenii_PYR-1 GKKADINVIDMDALRLDVPRMVYDLPADGRRLLQGASGYDATVVNGVVTR
Mflv_3315|M.gilvum_PYR-GCK GKKADINVIDMDALRLDVPRMVHDLPAGGRRLIQGASGYDATVVSGVVTR
MMAR_0213|M.marinum_M GKKADLNVIDLEALRLHPAAMAYDLPAGGNRILQGASGYAATIVSGAVTR
MAV_5277|M.avium_104 GKKADINVIDMDALRLHPAAMAFDLPAGGNRILQGASGYAATIVSGTVTR
TH_3974|M.thermoresistible__bu GKKADLNVIDLDALTLHPPRMVYDLPAGGHRLVQGASGYVATIVGGVVTR
MSMEG_0883|M.smegmatis_MC2_155 GFKADLNVIDHDALRLHKPVVTYDLPAGGRRLDQSADGYVATVVSGEVIA
MUL_1396|M.ulcerans_Agy99 GYKADLNVIDHAALRLHKPVIRYDLPAGGRRLDQTAEGYVATVVSGQVIA
Mb2937c|M.bovis_AF2122/97 GDRADFAVIDPTHLDESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGG
Rv2913c|M.tuberculosis_H37Rv GDRADFAVIDPTHLDESVDGYHEEAVPYYGGLRRMVNRNDATVVATGVGG
MAB_2605c|M.abscessus_ATCC_199 GDRADLFVIDPEKLDATLTAYAEESVDAYGGLSRMVNRNDATVSTVLIGG
* :**: *** * : : : .. **: :
Mvan_3037|M.vanbaalenii_PYR-1 -------------RHGVDTGARPGRLLRGVR--------------
Mflv_3315|M.gilvum_PYR-GCK -------------RFGVDTGERPGRLVRGVR--------------
MMAR_0213|M.marinum_M -------------RGGVDTGARPGRLVRGAR--------------
MAV_5277|M.avium_104 -------------RNDVDTGARPGRLVRGAR--------------
TH_3974|M.thermoresistible__bu -------------RDGVDTGARPGRLVRGAR--------------
MSMEG_0883|M.smegmatis_MC2_155 -------------ENGVPTAARPGRLVRGRQSAPA----------
MUL_1396|M.ulcerans_Agy99 -------------ENGVPTAARPGKLVRGRQPAPVPA--------
Mb2937c|M.bovis_AF2122/97 TVVFRGGQFGGQFRDGYGQNVKSGRYLRAGELGAALSRSA-----
Rv2913c|M.tuberculosis_H37Rv TVVFRGGQFGGQFRDGYGQNVKSGRYLRAGELGAALSRSA-----
MAB_2605c|M.abscessus_ATCC_199 QPVVVDG----QLRDLLGK-RRTGRFLPAGAKARAVPVDTAPAPH
. :.*: : .