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MTLTEDELGEARAVIARALDEDLRYGPDVTTLATVAADAHTTAAVVSREPGVVAGLDVALLVLDEVLGAD GYRVGHRVADGTRLEAGGVALTVEGPTRGLLTAERTLLNLVCHLSGIATATAAWVDAVSGTGAQIRDTRK TLPGLRALQKYAVRVGGGTNHRMGLGDAALIKDNHVAAAGSVVAALRQVRSAAPDLPCEVEVDSLEQLDE VLAEDVELVLLDNFPVWQTQIAVQRRDARSPKTKLESSGGLALENAADYAGTGVDYLAVGALTHSVRVLD LGLDL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2800 | - | - | 100% (285) | nicotinate-nucleotide pyrophosphorylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1622 | nadC | 1e-120 | 78.25% (285) | nicotinate-nucleotide pyrophosphorylase |
| M. gilvum PYR-GCK | Mflv_3617 | - | 1e-134 | 84.91% (285) | nicotinate-nucleotide pyrophosphorylase |
| M. tuberculosis H37Rv | Rv1596 | nadC | 1e-119 | 77.89% (285) | nicotinate-nucleotide pyrophosphorylase |
| M. leprae Br4923 | MLBr_01227 | nadC | 1e-118 | 75.62% (283) | nicotinate-nucleotide pyrophosphorylase |
| M. abscessus ATCC 19977 | MAB_2672c | - | 1e-120 | 75.35% (284) | nicotinate-nucleotide pyrophosphorylase |
| M. marinum M | MMAR_2393 | nadC | 1e-122 | 77.54% (285) | nicotinate-nucleotide pyrophosphatase NadC |
| M. avium 104 | MAV_3189 | nadC | 1e-120 | 77.39% (283) | nicotinate-nucleotide pyrophosphorylase |
| M. smegmatis MC2 155 | MSMEG_3201 | nadC | 1e-126 | 80.28% (284) | nicotinate-nucleotide pyrophosphorylase |
| M. thermoresistible (build 8) | TH_1164 | nadC | 1e-135 | 84.72% (288) | Probable nicotinate-nucleotide pyrophosphatase nadC |
| M. ulcerans Agy99 | MUL_1570 | nadC | 1e-121 | 76.84% (285) | nicotinate-nucleotide pyrophosphorylase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1622|M.bovis_AF2122/97 -------------MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPA
Rv1596|M.tuberculosis_H37Rv -------------MGLSDWELAAARAAIARGLDEDLRYGPDVTTLATVPA
MMAR_2393|M.marinum_M -------------MTLTDQERDAARETIRRGLDEDLRYGPDVTTIATVPA
MUL_1570|M.ulcerans_Agy99 -------------MTLTDQERDAARETIRRGLDEDLRYGPDVTTIATVPA
MLBr_01227|M.leprae_Br4923 ------------MIMLSDCEFDAARDTIRRALHEDLRYGLDITTQATVPA
MAV_3189|M.avium_104 --------------MISDCELTAAREIIRRGLVEDLRYGPDVTTLATVPA
Mvan_2800|M.vanbaalenii_PYR-1 -------------MTLTEDELGEARAVIARALDEDLRYGPDVTTLATVAA
Mflv_3617|M.gilvum_PYR-GCK -----------MLMTFSDYECAEARAVIARALEEDLRYGPDVTTTATVGA
TH_1164|M.thermoresistible__bu -------------MRLTDTEVAEARVTITRALDEDLRYGPDITTTATVPA
MSMEG_3201|M.smegmatis_MC2_155 ----------MLMMKLSDAELTAAKAAVARAVEEDLAYGPDVTTMATVDA
MAB_2672c|M.abscessus_ATCC_199 MRSCATVWSAMLTGTLTETELAEARSVVERALAEDLHYGPDITSRATVPA
::: * *: : *.: *** ** *:*: *** *
Mb1622|M.bovis_AF2122/97 SATTTASLVTREAGVVAGLDVALLTLDEVLGTNGYRVLDRVEDGARVPPG
Rv1596|M.tuberculosis_H37Rv SATTTASLVTREAGVVAGLDVALLTLNEVLGTNGYRVLDRVEDGARVPPG
MMAR_2393|M.marinum_M DATATASMVPREAGVIAGVDVALMVLDEVIGKDGYQVLGRVDDGARLQTG
MUL_1570|M.ulcerans_Agy99 DATATASMVPREAGVIAGVDVALMVLDEVIGKDGYQVLGRVDDGARLQTG
MLBr_01227|M.leprae_Br4923 GTVVTGSMVPREPGVIAGVDVALLVLDEVFGVDGYRVLYRVEDGARLQSG
MAV_3189|M.avium_104 EAVATASMVPRQPGVIAGVDIALLVLDEVLGARGYQVLDRVEDGAHLQPG
Mvan_2800|M.vanbaalenii_PYR-1 DAHTTAAVVSREPGVVAGLDVALLVLDEVLGADGYRVGHRVADGTRLEAG
Mflv_3617|M.gilvum_PYR-GCK DASTTGLMVPREPGVLAGGELAVMVLDEVIGSGAYSVEQLIPDGTRMDAG
TH_1164|M.thermoresistible__bu DARTTASMVAREPGVVAGIDVALLVLDEVLGPDGYQVVHRVDDGARLAAG
MSMEG_3201|M.smegmatis_MC2_155 AATTTASVVSREPGVIAGVDVALLVLDEMIGADRYRVLHRVDDGAQLDAK
MAB_2672c|M.abscessus_ATCC_199 DAECTASMVTRAGGVIAGVDIALIVLDQVVGAGNYRVDSRLTDGARVGTG
: *. :*.* **:** ::*::.*:::.* * * : **::: .
Mb1622|M.bovis_AF2122/97 EALMTLEAQTRGLLTAERTMLNLVGHLSGIATATAAWVDAVRGTKAKIRD
Rv1596|M.tuberculosis_H37Rv EALMTLEAQTRGLLTAERTMLNLVGHLSGIATATAAWVDAVRGTKAKIRD
MMAR_2393|M.marinum_M EPVLTIRAQTRGLLTAERTMLNLVCHLSGIATATAAWVEAVHGTKAKIRD
MUL_1570|M.ulcerans_Agy99 EPVLTIRAQTRGLLTGERTMLNLVCHLSGIATATAAWVEAVHGTKAKIRD
MLBr_01227|M.leprae_Br4923 QPLLTVQAAARGLLTAERTMLNLVCHMSGIATVTVAWVDAVRGTKAKIRD
MAV_3189|M.avium_104 QSLLTVRAETRGLLTAERTMLNLICHLSGIATTTAHWVAAVQGTKAQVRD
Mvan_2800|M.vanbaalenii_PYR-1 GVALTVEGPTRGLLTAERTLLNLVCHLSGIATATAAWVDAVSGTGAQIRD
Mflv_3617|M.gilvum_PYR-GCK TVALAVKAPTRGLLTAERTMLNLVCHLSGIATATAAWVDAVSGTGAQIRD
TH_1164|M.thermoresistible__bu GAALTVQAPTRGLLTAERTMLNLVCHLSGIATTTAAWVAAVEGTKARIRD
MSMEG_3201|M.smegmatis_MC2_155 QTVLTVEAPTRELLTAERTMLNLLCHLSGVATATAAWVDAVAGTKAKIRD
MAB_2672c|M.abscessus_ATCC_199 VSLLTVTAPTRDLLTAERTMLNLVCHLSGIATTTAAWVDAVDGTGARIRD
::: . :* ***.***:***: *:**:**.*. ** ** ** *::**
Mb1622|M.bovis_AF2122/97 TRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAGSVVDALR
Rv1596|M.tuberculosis_H37Rv TRKTLPGLRALQKYAVRTGGGVNHRLGLGDAALIKDNHVAAAGSVVDALR
MMAR_2393|M.marinum_M TRKTLPGLRALQKYAVRVGGGVNHRLGLGDAALIKDNHVAAAGSVLEALR
MUL_1570|M.ulcerans_Agy99 TRKTLPGLRALQKYAVRVGGGVNHRLGLGDAALIKDNHVAAAGSVLEALR
MLBr_01227|M.leprae_Br4923 TRKTLPGLRALQKYAVRVGGGVNHRLGLGDTALIKDNHVAAVGSVVDALR
MAV_3189|M.avium_104 TRKTLPGLRALQKYAVRVGGGVNHRLGLGDAALIKDNHVVAAGSVVDALR
Mvan_2800|M.vanbaalenii_PYR-1 TRKTLPGLRALQKYAVRVGGGTNHRMGLGDAALIKDNHVAAAGSVVAALR
Mflv_3617|M.gilvum_PYR-GCK TRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHVAAAGSVVAALR
TH_1164|M.thermoresistible__bu TRKTLPGLRALQKYAVRVGGGVNHRMGLGDAALIKDNHVAAAGSVVAALR
MSMEG_3201|M.smegmatis_MC2_155 TRKTLPGLRLLQKYAVRVGGGVNHRMGLGDAALIKDNHVAAAGSVVAALK
MAB_2672c|M.abscessus_ATCC_199 TRKTLPGLRLLQKYAVRAGGGVNHRLGLGDAALIKDNHVVAAGSVVAALR
********* *******.***.***:****:********.*.***: **:
Mb1622|M.bovis_AF2122/97 AVRNAAPDLPCEVEVDSLEQLDAVLPEKP---ELILLDNFAVWQTQTAVQ
Rv1596|M.tuberculosis_H37Rv AVRNAAPDLPCEVEVDSLEQLDAVLPEKP---ELILLDNFAVWQTQTAVQ
MMAR_2393|M.marinum_M AVRAAAPDLPCEVEVDSLEQLDEVLPEKP---ELILLDNFPVWQTQTAVQ
MUL_1570|M.ulcerans_Agy99 AVRAAAPDLPCEVEVDSLEQLDEVLPEKP---ELILLDNFPVWQTQTALQ
MLBr_01227|M.leprae_Br4923 AVRAAAPELPCEVEVDSLEQLDAMLAEEP---ELILLDNFPVWQTQVAVQ
MAV_3189|M.avium_104 AVRDAAPELPCEVEVDSLEQLDEVLPEKP---ELVLLDNFPVWQTQMAVQ
Mvan_2800|M.vanbaalenii_PYR-1 QVRSAAPDLPCEVEVDSLEQLDEVLAEDV---ELVLLDNFPVWQTQIAVQ
Mflv_3617|M.gilvum_PYR-GCK EVRAAAPDLPCEVEVDSLEQLDEVLAEGV---ELVLLDNFPVWQTQIAVQ
TH_1164|M.thermoresistible__bu AVRSAAPDLPCEVEVDSLEQLDEVLAEDLGEEALILLDNFPVWQTQIAVQ
MSMEG_3201|M.smegmatis_MC2_155 AVREEAPGLPCEVEVDSLEQLDEVLALGV---ELVLLDNFPVWQTQMAVQ
MAB_2672c|M.abscessus_ATCC_199 AVRAVAPDIECEVEVDSLEQLDEVMAEGA---ELVLLDNFPVWQAQVAVQ
** ** : ************ ::. *:*****.***:* *:*
Mb1622|M.bovis_AF2122/97 RRDSRAPTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDIGLD
Rv1596|M.tuberculosis_H37Rv RRDSRAPTVMLESSGGLSLQTAATYAETGVDYLAVGALTHSVRVLDIGLD
MMAR_2393|M.marinum_M RRDSRAPTVLLESSGGLSLDTAATYAATGVDYLAVGALTHSVRVLDIGLD
MUL_1570|M.ulcerans_Agy99 RRDSRAPTVLLESSGGLSLDTAATYAATGVDYLAVGALTHSVRVLDIGLD
MLBr_01227|M.leprae_Br4923 RRDIRAPTVLLESSGGLSLENAAIYAGTGVDYLAVGALTHSVRILDIGLD
MAV_3189|M.avium_104 RRDARAPAVLLESSGGLSLENAADYAATGVDYLAVGALTHSVRVLDIGLD
Mvan_2800|M.vanbaalenii_PYR-1 RRDARSPKTKLESSGGLALENAADYAGTGVDYLAVGALTHSVRVLDLGLD
Mflv_3617|M.gilvum_PYR-GCK RRDARSPQTKLESSGGLALENAAEYAGTGVDYLAVGALTHSVRVLDLGLD
TH_1164|M.thermoresistible__bu RRDSRSPETKLESSGGLALENAADYAATGVDYLAVGALTHSVRVLDIGLD
MSMEG_3201|M.smegmatis_MC2_155 RRDARAPETLLESSGGLTLDTAADYAGTGVDYLAIGALTHSVRVLDLGLD
MAB_2672c|M.abscessus_ATCC_199 RRDARAPQLKLEASGGLSLETAAAYAKTGVDYLAVGALTHSARVLDIGLD
*** *:* **:****:*:.** ** *******:******.*:**:***
Mb1622|M.bovis_AF2122/97 M
Rv1596|M.tuberculosis_H37Rv M
MMAR_2393|M.marinum_M M
MUL_1570|M.ulcerans_Agy99 M
MLBr_01227|M.leprae_Br4923 L
MAV_3189|M.avium_104 M
Mvan_2800|M.vanbaalenii_PYR-1 L
Mflv_3617|M.gilvum_PYR-GCK L
TH_1164|M.thermoresistible__bu V
MSMEG_3201|M.smegmatis_MC2_155 F
MAB_2672c|M.abscessus_ATCC_199 M
.