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MTALTADVRNGLDYKVADLSLAEFGRKEIRLAEHEMPGLMALRHEYAEVQPLKGARISGSLHMTVQTAVL IETLVALGAEVRWASCNIFSTQDHAAAAVVVGPNGTPEEPKGTPVFAWKGETLEEYWWAAEQMLTWEGKP ANMILDDGGDATMLVLRGAQYEKAGVVPPAEDDDPAEWKVFLSLVREGFEKDKTKWTKIAESVKGVTEET TTGVLRLYQFAAAGELAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKG CAESLAGQGARVAVTEIDPINALQALMDGFDVVTVEQGIAEADIVITSTGNKDIITLDHMKAMKNQAILG NIGHFDNEIDMAALERSGATRINIKPQVDQWIFESGKSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQVI AQIELWTKNDEYDNEVYRLAKHLDEKVARIHVEALGGTLTKLTKEQAEYIGVDVEGPYKPEHYRY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1746 | - | - | 100% (485) | S-adenosyl-L-homocysteine hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3276c | sahH | 0.0 | 87.45% (486) | S-adenosyl-L-homocysteine hydrolase |
| M. gilvum PYR-GCK | Mflv_4717 | - | 0.0 | 92.80% (486) | S-adenosyl-L-homocysteine hydrolase |
| M. tuberculosis H37Rv | Rv3248c | sahH | 0.0 | 87.65% (486) | S-adenosyl-L-homocysteine hydrolase |
| M. leprae Br4923 | MLBr_00771 | sahH | 0.0 | 86.63% (486) | S-adenosyl-L-homocysteine hydrolase |
| M. abscessus ATCC 19977 | MAB_3595c | - | 0.0 | 91.15% (486) | S-adenosyl-L-homocysteine hydrolase |
| M. marinum M | MMAR_1295 | sahH | 0.0 | 86.86% (487) | adenosylhomocysteinase SahH |
| M. avium 104 | MAV_4211 | ahcY | 0.0 | 84.29% (490) | S-adenosyl-L-homocysteine hydrolase |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_0466 | sahH | 0.0 | 91.70% (482) | PROBABLE ADENOSYLHOMOCYSTEINASE SAHH |
| M. ulcerans Agy99 | MUL_2592 | sahH | 0.0 | 86.65% (487) | S-adenosyl-L-homocysteine hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3276c|M.bovis_AF2122/97 MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLR
Rv3248c|M.tuberculosis_H37Rv MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLR
MMAR_1295|M.marinum_M MT---TTETSLSADTKNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLR
MUL_2592|M.ulcerans_Agy99 MT---TTETSLSADTKNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLR
MLBr_00771|M.leprae_Br4923 MT---TTENSLMPDVRNGIDFKVADLSLANFGRKELDLAEYEMPGLMSLR
Mvan_1746|M.vanbaalenii_PYR-1 MT-------ALTADVRNGLDYKVADLSLAEFGRKEIRLAEHEMPGLMALR
Mflv_4717|M.gilvum_PYR-GCK MT-------ALTADVRNGIDYKVADLSLAEFGRKEIRLAEHEMPGLMELR
MAB_3595c|M.abscessus_ATCC_199 MT-------ELVADVRNGIEYKVADLSEAEFGRKEIRLAEHEMPGLMALR
TH_0466|M.thermoresistible__bu MTT----TEKMTADVRNGIDFKVADLSLAEFGRMEIRLAEHEMPGLMALR
MAV_4211|M.avium_104 MT---TTENALTPDVRNGIEFKVADLSLADYGRRDIELSEQEMPGLMSLR
** : .*.:**:::*:**** *::** :: ::* ****** **
Mb3276c|M.bovis_AF2122/97 REYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQD
Rv3248c|M.tuberculosis_H37Rv REYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQD
MMAR_1295|M.marinum_M REYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQD
MUL_2592|M.ulcerans_Agy99 REYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQD
MLBr_00771|M.leprae_Br4923 HEYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQD
Mvan_1746|M.vanbaalenii_PYR-1 HEYAEVQPLKGARISGSLHMTVQTAVLIETLVALGAEVRWASCNIFSTQD
Mflv_4717|M.gilvum_PYR-GCK REYHDVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQD
MAB_3595c|M.abscessus_ATCC_199 REYAEVLPLKGARISGSLHMTIQTAVLIETLVALGAEVRWASCNIFSTQD
TH_0466|M.thermoresistible__bu REYADVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQD
MAV_4211|M.avium_104 REYHDVQPLKGARISGSLHMTVQTAVLIETLVALGAEVRWASCNIFSTQD
:** :* **************:*********.******************
Mb3276c|M.bovis_AF2122/97 HAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDP----
Rv3248c|M.tuberculosis_H37Rv HAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDP----
MMAR_1295|M.marinum_M HAAAAVVVGPHGTPEEPKGVPVFAWKGESLEEYWWCAEQMLTWPDS----
MUL_2592|M.ulcerans_Agy99 HAAAAVVVGPHGTPEEPKGVPVFAWKGESLEEYWWCAEQMLTWPDS----
MLBr_00771|M.leprae_Br4923 HAAAAVVVGPYGTPEEPKGVPVFAWKGETLEEYWWAAEQMLTWPDP----
Mvan_1746|M.vanbaalenii_PYR-1 HAAAAVVVGPNGTPEEPKGTPVFAWKGETLEEYWWAAEQMLTWE------
Mflv_4717|M.gilvum_PYR-GCK HAAAAVVVGPNGTPEEPKGTPVFAWKGETLEEYWWAAEQMLTWP------
MAB_3595c|M.abscessus_ATCC_199 HAAAAVVVGPNGTPEEPQGTPVFAWKGETLEEYWWAAEQMLTWP------
TH_0466|M.thermoresistible__bu HAAAAVVVGPHGTPEEPKGVSVFAWKGETLEEYWWAAEQMLTWP------
MAV_4211|M.avium_104 HAAAAVVVGPHGTPEEPRGVPVFAWKGETLEEYWWAAEQALTWPPLADGT
********** ***:**:*..*******:******.*** ***
Mb3276c|M.bovis_AF2122/97 DKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKIFLNLLRT
Rv3248c|M.tuberculosis_H37Rv DKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRT
MMAR_1295|M.marinum_M DKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDSAEWKVFLGLLRS
MUL_2592|M.ulcerans_Agy99 DKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDSAEWKVFLGLLRS
MLBr_00771|M.leprae_Br4923 DKPVNMILDDGGDATMLVLRGVQYEKAGVVPPAEVDDSAEWKVFLNLLRK
Mvan_1746|M.vanbaalenii_PYR-1 GKPANMILDDGGDATMLVLRGAQYEKAGVVPPAEDDDPAEWKVFLSLVRE
Mflv_4717|M.gilvum_PYR-GCK GEPANMILDDGGDATMLVLRGAQYEKAGVVPPAEDDDSAEWKVFLELCRK
MAB_3595c|M.abscessus_ATCC_199 NEPANMILDDGGDATMLVLRGAQFEQAGVVPPADDNDSAEYKVFLNLLRE
TH_0466|M.thermoresistible__bu GEPANMILDDGGDATMMVLRGAQYEKQGVVPPVEEDDPAEWKVFLSTLRK
MAV_4211|M.avium_104 EAPANMILDDGGDATMLVLRGAQYEKAGVVPPDDEDDSAEHRVFLNLLRE
*.************:**** *:*: ***** : :*.** ::** *
Mb3276c|M.bovis_AF2122/97 RFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSV
Rv3248c|M.tuberculosis_H37Rv RFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSV
MMAR_1295|M.marinum_M RFETDKGKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSV
MUL_2592|M.ulcerans_Agy99 RFETDKGKWTKIAESVKGVTEETTTGVLRLYQFAEAGDLAFPAINVNDSV
MLBr_00771|M.leprae_Br4923 RFETDKGKWTKIAKSVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSV
Mvan_1746|M.vanbaalenii_PYR-1 GFEKDKTKWTKIAESVKGVTEETTTGVLRLYQFAAAGELAFPAINVNDSV
Mflv_4717|M.gilvum_PYR-GCK GYEQSKDKWTKIAESVQGVTEETTTGVLRLYQFAAAGELAFPAINVNDSV
MAB_3595c|M.abscessus_ATCC_199 RFETDKDKWTKIAESVQGVTEETTTGVLRLYQFAAAGELAFPAINVNDSV
TH_0466|M.thermoresistible__bu TFETDKTKWTKIAESVKGVTEETTTGVLRLYQFEAAGELPFPAINVNDSV
MAV_4211|M.avium_104 RFETDKTKWTKISESIKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSV
:* .* *****::*::**************** **:*.**********
Mb3276c|M.bovis_AF2122/97 TKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKG
Rv3248c|M.tuberculosis_H37Rv TKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKG
MMAR_1295|M.marinum_M TKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKG
MUL_2592|M.ulcerans_Agy99 TKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKG
MLBr_00771|M.leprae_Br4923 TKSKFDNKYGTRHSLIDGINRGTDSLIGGKNVLICGYGDVGKGCAEAAKG
Mvan_1746|M.vanbaalenii_PYR-1 TKSKFDNKYGTRHSLIDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAG
Mflv_4717|M.gilvum_PYR-GCK TKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAESLAG
MAB_3595c|M.abscessus_ATCC_199 TKSKFDNKYGTRHSLVDGINRGTDVLIGGKKVLICGYGDVGKGCAESLAG
TH_0466|M.thermoresistible__bu TKSKFDNKYGTRHSLIDGINRGTDVLIGGKKALVCGYGDVGKGCAESLAG
MAV_4211|M.avium_104 TKSKFDNKYGCRHSLIDGINRGTDVLIGGKNVLVCGYGDVGKGSVESLAG
********** ****:******** *****:.*:*********..*: *
Mb3276c|M.bovis_AF2122/97 QGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIML
Rv3248c|M.tuberculosis_H37Rv QGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIML
MMAR_1295|M.marinum_M QGARVSVTEIDPINALQAMMEGFDVVTVEDAIGDADIVVTSTGNKDIIML
MUL_2592|M.ulcerans_Agy99 QGARVSVTEIDPINALQAMMEGFDVVTVEDAIGDADIVVTSTGNKDIIML
MLBr_00771|M.leprae_Br4923 QGARVTITEIDPINALQALMEGFDVKRVEDVIADSDIVVTATGNKDIILL
Mvan_1746|M.vanbaalenii_PYR-1 QGARVAVTEIDPINALQALMDGFDVVTVEQGIAEADIVITSTGNKDIITL
Mflv_4717|M.gilvum_PYR-GCK QGARVQVTEIDPINALQALMDGYDVVTVEQAIGDADIVITSTGNKDIITL
MAB_3595c|M.abscessus_ATCC_199 QGARVQVTEIDPINALQALMDGFDVVTVEQAIGDADIVVTATGNFDIILL
TH_0466|M.thermoresistible__bu QGARVQVTEIDPINALQALMDGFDVVTVEQAIADADIVITATGNKDIITL
MAV_4211|M.avium_104 QGARVTVTEIDPINALQALMEGYNVKRVEDVIGEADIVITATGNKDIITL
***** :***********:*:*::* **: *.::***:*:*** *** *
Mb3276c|M.bovis_AF2122/97 EHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTG
Rv3248c|M.tuberculosis_H37Rv EHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTG
MMAR_1295|M.marinum_M EHIKAMKDHSILGNIGHFDNEIDMAGLERSGATRTNIKPQVDLWTFGDTG
MUL_2592|M.ulcerans_Agy99 EHIKAMKDHSILGNIGHFDNEIDMAGLERSGATRTNIKPQVDLWTFGDTG
MLBr_00771|M.leprae_Br4923 EHMKAMKDHAILGNIGHFDNEIDMAALERSGATRLNIKPQVDLWTFGDSG
Mvan_1746|M.vanbaalenii_PYR-1 DHMKAMKNQAILGNIGHFDNEIDMAALERSGATRINIKPQVDQWIF-ESG
Mflv_4717|M.gilvum_PYR-GCK DHMKAMKDHSILGNIGHFDNEIDIAALERSGATRINIKPQVDEWTFGETG
MAB_3595c|M.abscessus_ATCC_199 EHMKAMKDQAILGNIGHFDNEIDMAALEKSGAVRLNIKPQVDLWTFGDSG
TH_0466|M.thermoresistible__bu EHMRAMKNQAILGNIGHFDNEIDMAGLERSGAKKTNIKPQVDLWTF-EDG
MAV_4211|M.avium_104 EHMKAMKDKAILGNIGHFDNEIQIARLEKSGAIKTNIRPQVDLWTFPDTG
:*::***:::************::* **:*** : *::**** * * : *
Mb3276c|M.bovis_AF2122/97 RSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEV
Rv3248c|M.tuberculosis_H37Rv RSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEV
MMAR_1295|M.marinum_M RSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEV
MUL_2592|M.ulcerans_Agy99 RSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEV
MLBr_00771|M.leprae_Br4923 KSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDDYDNEV
Mvan_1746|M.vanbaalenii_PYR-1 KSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEV
Mflv_4717|M.gilvum_PYR-GCK KSIILLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEV
MAB_3595c|M.abscessus_ATCC_199 KSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEV
TH_0466|M.thermoresistible__bu KSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNAV
MAV_4211|M.avium_104 KSIIVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEV
:***:************************:**.***********:*** *
Mb3276c|M.bovis_AF2122/97 YRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY
Rv3248c|M.tuberculosis_H37Rv YRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY
MMAR_1295|M.marinum_M YRLPKHLDEKVARIHVEALGGRLTKLTKDQAEYLGVDVEGPYKPDHYRY
MUL_2592|M.ulcerans_Agy99 YRLPKHLDEKVARIHVEALGGRLTKLTKDQAEYLGVDVEGPYKPDHYRY
MLBr_00771|M.leprae_Br4923 YRLPKHLDEKVARVHVEALGGQLTKLTKDQAEYLGVDVDGPFKPDHYRY
Mvan_1746|M.vanbaalenii_PYR-1 YRLAKHLDEKVARIHVEALGGTLTKLTKEQAEYIGVDVEGPYKPEHYRY
Mflv_4717|M.gilvum_PYR-GCK YRLAKHLDEKVAKIHVEALGGTLTRLTKDQAEYIGVDVEGPYKPEHYRY
MAB_3595c|M.abscessus_ATCC_199 YRLAKHLDEKVARIHVEALGGTLTKLTKDQAEYIGVDVEGPYKPEHYRY
TH_0466|M.thermoresistible__bu YRLPKHLDEKVARIHVEALGGTLTKLTKEQAEYIGVDVEGPYKPEHYRY
MAV_4211|M.avium_104 YRLPKHLDEKVARIHVEALGGELTKLTKEQAEYIGVDVDGPYKADHYRY
***.********::******* **:***:****:****:**:*.:****