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SRPAEAVQRVIKAYDVRGLVGVDIDEAFVADVGAAFARLVRDSLEQPATQVAIGHDMRASSPALSKAFAD GVLAQGLDVVHIGLASTDQLYFASGLLDCPGAMFTASHNPAAYNGIKLCRAGAKPVGRETGLAAVAEEVI AGVPGYDGPHGSVSERDVLADYGDFLRSLVDIGGDRPLRVAVDAGNGMAGHTAPAVLGSIASLTLKPLYF ELDGEFPNHEANPLDPANLVDLQAFVLETGADIGLAFDGDADRCFVVDERGQAVSPSAVTALVAARELNR EIGATVIHNLITSRAVPELVGERGGTAVRSRVGHSYIKALMAETGAIFGGEHSAHYYFRDFWGADSGMLA ALHVLAALGEQDRPLSEMMADYQRYEASGEINFTVTDAPEIVDSVLQALGGRIHAIDHLDGVTVDLGDGR WFNIRMSNTEPLLRLNVEARTAEEVTEIVDEIGGYITSGARAST*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4726 | manB | - | 100% (465) | phosphomannomutase/phosphoglucomutase |
| M. gilvum PYR-GCK | Mflv_4947 | glmM | 5e-32 | 26.42% (458) | phosphoglucosamine mutase |
| M. gilvum PYR-GCK | Mflv_4831 | - | 1e-11 | 25.48% (361) | phosphoglucomutase/phosphomannomutase alpha/beta/subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3285c | manB | 0.0 | 77.34% (459) | phosphomannomutase/phosphoglucomutase |
| M. tuberculosis H37Rv | Rv3257c | manB | 0.0 | 77.12% (459) | phosphomannomutase/phosphoglucomutase |
| M. leprae Br4923 | MLBr_00763 | manB | 0.0 | 75.54% (462) | phosphomannomutase/phosphoglucomutase |
| M. abscessus ATCC 19977 | MAB_3603c | manB | 0.0 | 75.54% (462) | phosphomannomutase/phosphoglucomutase |
| M. marinum M | MMAR_1285 | manB | 0.0 | 75.65% (460) | phosphomannomutase PmmA |
| M. avium 104 | MAV_4384 | glmM | 6e-31 | 28.17% (458) | phosphoglucosamine mutase |
| M. smegmatis MC2 155 | MSMEG_1834 | manB | 0.0 | 81.40% (457) | phosphomannomutase/phosphoglucomutase |
| M. thermoresistible (build 8) | TH_0773 | - | 0.0 | 80.34% (468) | phosphomannomutase/phosphoglucomutase |
| M. ulcerans Agy99 | MUL_2602 | manB | 0.0 | 75.33% (458) | phosphomannomutase/phosphoglucomutase |
| M. vanbaalenii PYR-1 | Mvan_1737 | manB | 0.0 | 86.88% (465) | phosphomannomutase/phosphoglucomutase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3285c|M.bovis_AF2122/97 MSWPAAAVDRVIKAYDVRGLVGEEIDESLVTDLGAAFARLMRT---EDAR
Rv3257c|M.tuberculosis_H37Rv MSWPAAAVDRVIKAYDVRGLVGEEIDESLVTDLGAAFARLMRT---EDAR
MMAR_1285|M.marinum_M MSWPAAVINRVIKAYDVRGLVGEEITEALCADIGAAFARLMRG---EGAR
MUL_2602|M.ulcerans_Agy99 MSWPAAVINRVIKAYDVRGLVGEEITEALCADIGAAFARLMRG---EGAR
MLBr_00763|M.leprae_Br4923 MSRPAAAVHRVVKAYDVRGLVGKEIDESLSADFGAAFARLMRA---EGAR
Mflv_4726|M.gilvum_PYR-GCK MSRPAEAVQRVIKAYDVRGLVGVDIDEAFVADVGAAFARLVRDSLEQPAT
Mvan_1737|M.vanbaalenii_PYR-1 MSRPAAAVQRVIKAYDVRGLVGEEIDESFVRDVGAAFARLVRD-AAQPAS
MSMEG_1834|M.smegmatis_MC2_155 MSRPAAAVHGVIKAYDVRGLVGSELDESFVADVGGAFARLVRG---EGAR
TH_0773|M.thermoresistible__bu MSWPAEAVHRVIKAYDVRGLVGEEITEEFVADVGAAFARLMRSELAETAT
MAB_3603c|M.abscessus_ATCC_199 MARSADAVHAVIKAYDVRGLLGEQIDESFVFDVGSSFARLIKAERDDSAD
MAV_4384|M.avium_104 -------MGRLFGTDGVRGVANRELTAELALALGAAAARQLASGSAPGRR
: :. : .***: . :: : .*.: ** :
Mb3285c|M.bovis_AF2122/97 P-----VVIGHDMRDSSPSLADAFAAGVTGQGLDVVRVGLASTDQLYFAS
Rv3257c|M.tuberculosis_H37Rv P-----VVIGHDMRDSSPSLADAFAAGVTGQGLDVVRVGLASTDQLYFAS
MMAR_1285|M.marinum_M Q-----VVIGYDMRDSSPALAAAFASGVVAQGLDVVRIGLASTDQLYFAA
MUL_2602|M.ulcerans_Agy99 Q-----VVIGYDMRDSSPALAAAFASGVVAQGLGVVRIGLGSTDQLYFAA
MLBr_00763|M.leprae_Br4923 Q-----VVLGYDMRDSSPSLAAAFATGVTGQGVDVVRIGLSSTDQLYFAA
Mflv_4726|M.gilvum_PYR-GCK Q-----VAIGHDMRASSPALSKAFADGVLAQGLDVVHIGLASTDQLYFAS
Mvan_1737|M.vanbaalenii_PYR-1 Q-----IVIGHDMRASSPTLSAAFADGVTAQGLDVVRIGLASTDQLYFAS
MSMEG_1834|M.smegmatis_MC2_155 Q-----VVIGHDMRSSSPALAAAFADGVTTQGLDVVRIGLASTDQLYFAS
TH_0773|M.thermoresistible__bu TG--PTVVIGHDMRASSPGLAAAFADGVTKQGVDVVRIGLASTDQLYFAS
MAB_3603c|M.abscessus_ATCC_199 SSRAPRVVVGRDMRDSSPSLAQAFTDGVTAQGVDVVQIGLASTDQLYFAS
MAV_4384|M.avium_104 V-----AVIGRDPRASGEMLEAAVIAGLTSQGVDALRVGVLPTPAVAYLT
.:* * * *. * *. *: **:..:::*: .* : : :
Mb3285c|M.bovis_AF2122/97 GLLDCP-GAMFTASHNPAAYNGIKMCRAAAKPVGADTGLTAIRDDLIAGV
Rv3257c|M.tuberculosis_H37Rv GLLDCP-GAMFTASHNPAAYNGIKMCRAAAKPVGADTGLTAIRDDLIAGV
MMAR_1285|M.marinum_M GQLDCP-GAMFTASHNPAAYNGIKLCRAGAKPVGADTGLNAIREDLVNPV
MUL_2602|M.ulcerans_Agy99 GQLDCP-GAMFTASHNPAAYNGIKLCRAGAKPVGADTGLNAIREDLVNPV
MLBr_00763|M.leprae_Br4923 GLLDCP-GAMFTASHNPAAYNGIKLCLAGAKPVGADTGLAIIRDDVIAGI
Mflv_4726|M.gilvum_PYR-GCK GLLDCP-GAMFTASHNPAAYNGIKLCRAGAKPVGRETGLAAVAEEVIAGV
Mvan_1737|M.vanbaalenii_PYR-1 GLLDCP-GAMFTASHNPAAYNGIKLCRAGAKPVGKDTGLTVISDEVIAGV
MSMEG_1834|M.smegmatis_MC2_155 GLLECP-GAMFTASHNPAAYNGIKLCRAGAKPVGKDTGLAAISEEVIGGV
TH_0773|M.thermoresistible__bu GLLDCP-GAMFTASHNPAAYNGIKLCRAGAKPVGRDTGLTQISDMVIAGV
MAB_3603c|M.abscessus_ATCC_199 GLLDCP-GAMFTASHNPAAYNGIKLCRAGAKPVGKDTGLSVISGELIDGV
MAV_4384|M.avium_104 GAYDADFGVMISASHNPMPDNGIKIFGPGGHKLDDGTEDRIEALVGDAGP
* :. *.*::***** . ****: ...: :. *
Mb3285c|M.bovis_AF2122/97 AR---YDGTPGTIADQDVLVDYGAFLRSLVDTSGLRPLRVAVDAGNGMAG
Rv3257c|M.tuberculosis_H37Rv AR---YDGTPGTIADQDVLVDYGAFLRSLVDTSGLRPLRVAVDAGNGMAG
MMAR_1285|M.marinum_M AIA--VAETAGTIADKDVLGDYGVFLRSLVNTADLRPLRVAVDAGNGMAG
MUL_2602|M.ulcerans_Agy99 AIA--VAETAGTIADKDVLGDYGVFLRSLVNTADLRPLRVAVDAGNGMAG
MLBr_00763|M.leprae_Br4923 PPYPLSRGRPGTIADRDVLADYGVFLRSLVNTAGLRPLRVAVDAGNGMAG
Mflv_4726|M.gilvum_PYR-GCK PG---YDGPHGSVSERDVLADYGDFLRSLVDIGGDRPLRVAVDAGNGMAG
Mvan_1737|M.vanbaalenii_PYR-1 PD---YDGPRGRVSDRDVLADYGEFLRSLVDISAARPLHVAVDAGNGMAG
MSMEG_1834|M.smegmatis_MC2_155 PA---HDGPRGGITDRDVLADYGEFLRSLVDLSGSRPLRIAVDAGNGMAG
TH_0773|M.thermoresistible__bu PE---HDGAAGAVRDQDVLADYGDFLRSLVDLTELRPLRVAVDAGNGMAG
MAB_3603c|M.abscessus_ATCC_199 PG---YDGPVGTVTERDVLAEYGDFLRSLVQLSGARPLRVAVDAGNGMAG
MAV_4384|M.avium_104 RP---VGAGIGRVIDAEDAADRYLRHLSKASTLRLDGLTVVVDCAHGAAS
* : : : : * .. * :.**..:* *.
Mb3285c|M.bovis_AF2122/97 HTAPAVLGVIDSITLLPLYFELDGSFPNHEANPLDPANLVDLQAYVRDTG
Rv3257c|M.tuberculosis_H37Rv HTAPAVLGVIDSITLLPSYFELDGSFPNHEANPLDPANLVDLQAYVRDTG
MMAR_1285|M.marinum_M HTAPAVLGAIDSVTLLPLYFELDGTFPNHEANPLDPANLLDLQKFVVATG
MUL_2602|M.ulcerans_Agy99 HTAPAVLGAIDSVTLLPLYFELDGTFPNHEANPLDPANLLDLQKFVVATG
MLBr_00763|M.leprae_Br4923 HTTPAVLGAIDSITLLPLYFELDGSFPNHEANPLDPANLVDLQAYVRDTG
Mflv_4726|M.gilvum_PYR-GCK HTAPAVLGSIASLTLKPLYFELDGEFPNHEANPLDPANLVDLQAFVLETG
Mvan_1737|M.vanbaalenii_PYR-1 HTAPAVLGPISSITLSPLYFELDGDFPNHEANPLNPANLVDLQNFVRETG
MSMEG_1834|M.smegmatis_MC2_155 HTTPAVLGPIPGATILPLYFELDGTFPNHEANPLDPANLVDLQRFVVESG
TH_0773|M.thermoresistible__bu HTTPAVLGEVPAITLLPLYFELDGTFPNHEANPLDPANLVDLQRHVVATG
MAB_3603c|M.abscessus_ATCC_199 HTTPAVLGAIPSITLAPLYFELDGNFPNHEANPLDAENLRDLQAFVAAES
MAV_4384|M.avium_104 SVAPRAYRAAG-ARVIAINADPNGLNINDNCG---STHLDSLRAAVVAHR
.:* . : . : :* *.:.. . :* .*: *
Mb3285c|M.bovis_AF2122/97 ADIGLAFDGDADRCFVVDERGQPVS--PSTVTALVAARELNREIGATIIH
Rv3257c|M.tuberculosis_H37Rv ADIGLAFDGDADRCFVVDERGQPVS--PSTVTALVAARELNREIGATIIH
MMAR_1285|M.marinum_M ADIGLAFDGDADRCFVVDERGEPVS--PSTVTSLVAARELSREIGATVIH
MUL_2602|M.ulcerans_Agy99 ADIGLAFDGDADRCFVVDERGEPVS--PSTVTSLVAARELSREIGATVIH
MLBr_00763|M.leprae_Br4923 ADIGLAFDGDADRCFVVDERGLSVS--PSTVTSLVAARALKREIGATIIY
Mflv_4726|M.gilvum_PYR-GCK ADIGLAFDGDADRCFVVDERGQAVS--PSAVTALVAARELNREIGATVIH
Mvan_1737|M.vanbaalenii_PYR-1 ADIGLAFDGDADRCFVVDETGAAVS--PSAVTALVAARELQREIGATVIH
MSMEG_1834|M.smegmatis_MC2_155 ADIGLAFDGDADRCFVVDELGRPVS--PSAVTALVAGRELTREIGATIIH
TH_0773|M.thermoresistible__bu ADIGLAFDGDADRCFVVDEKGGLVS--PSAVTALVAVRELNREIGATIIH
MAB_3603c|M.abscessus_ATCC_199 ADIGLAFDGDADRCFVVDERGRAVS--PSAVTALVARRELEREIGGTIIH
MAV_4384|M.avium_104 ADLGLAHDGDADRCLAVDADGNLVDGDHIMVVLALAMREAGELASDTLVT
**:***.*******:.** * *. *. :* * . . *::
Mb3285c|M.bovis_AF2122/97 NVITSRAVPELVAERGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHYYF
Rv3257c|M.tuberculosis_H37Rv NVITSRAVPELVAERGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHYYF
MMAR_1285|M.marinum_M NVITSRAVPELVVERGGTPLRSRVGHSYIKALMADTGAIFGGEHSAHYYF
MUL_2602|M.ulcerans_Agy99 NVITSRAVPELVVERGGTPLRSRVGHSYIKALMADTGAIFGGEHSAHYYF
MLBr_00763|M.leprae_Br4923 NVITSRAVPELVSECGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHYYF
Mflv_4726|M.gilvum_PYR-GCK NLITSRAVPELVGERGGTAVRSRVGHSYIKALMAETGAIFGGEHSAHYYF
Mvan_1737|M.vanbaalenii_PYR-1 NLITSRAVPELVTERGGTPVRSRVGHSYIKGLMAETGAIFGGEHSAHYYF
MSMEG_1834|M.smegmatis_MC2_155 NLITSRAVPELVTERGGTPVRARVGHSYIKALMAETSAIFGGEHSAHYYF
TH_0773|M.thermoresistible__bu NLITSRAVPELITERGGTPVRSRVGHSYIKALMAETGAIFGGEHSAHYYF
MAB_3603c|M.abscessus_ATCC_199 NLITSRAVPELVVEHGGTPVRSRVGHSFIKALMAETGAIFGGEHSAHYYF
MAV_4384|M.avium_104 TVMSNLGLHLAMRSAGITVRTTGVGDRYVVEELRAGDYSLGGEQSGHIVM
.:::. .: : . * * : **. :: : . :***:*.* :
Mb3285c|M.bovis_AF2122/97 RDFWGADSGMLAALHVLAALGEQSRPLSELTADYQRYESSGEINFTVVDS
Rv3257c|M.tuberculosis_H37Rv RDFWGADSGMLAALHVLAALGEQSRPLSELTADYQRYESSGEINFTVVDS
MMAR_1285|M.marinum_M RDFWGADSGMLAALYVLAALGEQSRPLSELTADYQRYASSGEINFTVADA
MUL_2602|M.ulcerans_Agy99 RDFWGADSGMLAALYVLAALGEQSRPLSELTADYQRYASSGEINFTVADA
MLBr_00763|M.leprae_Br4923 RDFWGADSGMLAALYVLAALGEQQRPLSELAADYQRYESSGEINFTVADA
Mflv_4726|M.gilvum_PYR-GCK RDFWGADSGMLAALHVLAALGEQDRPLSEMMADYQRYEASGEINFTVTDA
Mvan_1737|M.vanbaalenii_PYR-1 RDFWGADSGMLAALHVLAALGEQDRPLSEMMADYQRYEASGEINYTVADA
MSMEG_1834|M.smegmatis_MC2_155 RDFWGADSGMLAALHVLAALGEQDRPLSEIMADYQRYEASGEINFTVSDA
TH_0773|M.thermoresistible__bu RDFWGADSGMLAALHVLAALGEQDRPLSEVMADYQRYEASGEINFTVGDA
MAB_3603c|M.abscessus_ATCC_199 RDFWGADSGMLAALHVLAALSEQERPLSDLMSDYERYAASGEINFRVSNA
MAV_4384|M.avium_104 PALGSTGDGIVTGLRLMTRMAQTGSPLSDLASAMQTLP-QVLINVTVADK
: .:..*:::.* ::: :.: ***:: : : . ** * :
Mb3285c|M.bovis_AF2122/97 SACVEAVLKSFGNRIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVE
Rv3257c|M.tuberculosis_H37Rv SACVEAVLKSFGNRIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVE
MMAR_1285|M.marinum_M PACVEGVLKSFGSRIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVE
MUL_2602|M.ulcerans_Agy99 PACVEGVLKSFGSRIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVE
MLBr_00763|M.leprae_Br4923 PSCMDAVVEFFGSQIHSIDHLDGVTVDLGGGSWFNLRNSNTEPLLRLNVE
Mflv_4726|M.gilvum_PYR-GCK PEIVDSVLQALGGRIHAIDHLDGVTVDLGDGRWFNIRMSNTEPLLRLNVE
Mvan_1737|M.vanbaalenii_PYR-1 PAIVDSVLQEFASRIYAIDHLDGVTVDLGEGRWFNLRMSNTEPLLRLNVE
MSMEG_1834|M.smegmatis_MC2_155 SACVDAVLTSYGTAIHSIDHLDGVTVDLGDDCWFNLRSSNTEPLLRLNVE
TH_0773|M.thermoresistible__bu AACVEQVLKAFGSEIQSIDHLDGVTVDLGGGRWFNLRSSNTEPLLRLNVE
MAB_3603c|M.abscessus_ATCC_199 GACIDEVLKSFGTQIVSIDHLDGVTVDIGAGTWFNLRTSNTEPLLRLNVE
MAV_4384|M.avium_104 ATAATAPSVQT--------AVGQAAAELGDTGRILLRPSGTEPMIRVMVE
:. .:.::* : :* *.***::*: **
Mb3285c|M.bovis_AF2122/97 GRSVGDVDAVVRQVS---------AEIAAQSAHAKAGP
Rv3257c|M.tuberculosis_H37Rv GRSVGDVDAVVRQVS---------AEIAAQSAHAKAGP
MMAR_1285|M.marinum_M ARSAEDVDAVVQQVS---------AEIAAQSPRGEAGP
MUL_2602|M.ulcerans_Agy99 ARSAGDVDAVVQQVS---------AEIAVQSPRGEAGP
MLBr_00763|M.leprae_Br4923 GRSTEDVDVVVAQIS---------AQIAAHISGPEAEP
Mflv_4726|M.gilvum_PYR-GCK ARTAEEVTEIVDEIG---------GYITSGARAST---
Mvan_1737|M.vanbaalenii_PYR-1 ARSADEVTELVDEIG---------GYITSGVKEST---
MSMEG_1834|M.smegmatis_MC2_155 ARTTEEVDAVVDRIADVIRATNEPGSVNGAVNEAAT--
TH_0773|M.thermoresistible__bu ARTTEEVDAIVERVA---------ARITATGSGAS---
MAB_3603c|M.abscessus_ATCC_199 ARTDEDVAAVVARIS----------DLVDRTEAAT---
MAV_4384|M.avium_104 APEKDIAQRLATRVA-------------EAVSAAR---
. . :. .:.