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ADKAQRKADKPGKKTKKSKLPGDVYEAELFRLQTELVKLQEWVRATGARVVVVFEGRDAAGKGGAIKRVT EYLSPRVATIAALPAPTERERGQWYFQRYIQHLPTSGEIVLFDRSWYNRAGVEKVMGFCTPAEHALFLRQ APIFEQMLIEDGIILRKYWFSVSGEEQLRRFKSRHSDPVRRWKLSPMDLESVYRWEDYSRAKDEMMAHTD TPLSPWYVVESDIKKHARLNMIAHLLSTIDYYDVEAPKVTLPKKVVCSADYQRPPREASTYVDDHVASLM GDRE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4701 | - | - | 100% (285) | hypothetical protein Mflv_4701 |
| M. gilvum PYR-GCK | Mflv_0104 | - | 8e-23 | 28.68% (258) | hypothetical protein Mflv_0104 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3261c | pvdS | 1e-127 | 78.06% (278) | transcriptional regulatory protein PvdS |
| M. tuberculosis H37Rv | Rv3232c | pvdS | 1e-127 | 78.06% (278) | transcriptional regulatory protein PvdS |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4135c | - | 3e-78 | 61.64% (219) | hypothetical protein MAB_4135c |
| M. marinum M | MMAR_1312 | pvdS | 1e-127 | 75.62% (283) | transcriptional regulatory protein PvdS |
| M. avium 104 | MAV_4195 | - | 1e-127 | 77.78% (279) | polyphosphate kinase 2 |
| M. smegmatis MC2 155 | MSMEG_0891 | - | 3e-80 | 63.13% (217) | polyphosphate kinase 2 |
| M. thermoresistible (build 8) | TH_1923 | - | 1e-27 | 31.33% (233) | polyphosphate kinase 2 superfamily protein |
| M. ulcerans Agy99 | MUL_2568 | pvdS | 1e-127 | 75.62% (283) | transcriptional regulatory protein PvdS |
| M. vanbaalenii PYR-1 | Mvan_0772 | - | 1e-79 | 58.62% (232) | hypothetical protein Mvan_0772 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0891|M.smegmatis_MC2_155 -MLDSTG------------------YAVRDDDDDDPELLL-PGGEVVDTW
Mvan_0772|M.vanbaalenii_PYR-1 MTLDNPGRTVGSADPSRLVGSADPSYIVVDDDDDDPVLLLQPSGEVVDTW
MAB_4135c|M.abscessus_ATCC_199 -MTDTITAAAEG-------------YTVDDDDDDDPVLIA-PDGVAVDTW
MMAR_1312|M.marinum_M ---------------------------MSTATNDGA-----PAKAKKKKK
MUL_2568|M.ulcerans_Agy99 ---------------------------MSTATNDGA-----PAKAKKKKK
MAV_4195|M.avium_104 ---------------------------MSSAKNDGV-----PLKAGKKKS
Mb3261c|M.bovis_AF2122/97 --------------------MDIPSVDVSTATNDGA-----SSRAKGHR-
Rv3232c|M.tuberculosis_H37Rv --------------------MDIPSVDVSTATNDGA-----SSRAKGHR-
Mflv_4701|M.gilvum_PYR-GCK ---------------------------MADKAQRKA-----DKPGKKTK-
TH_1923|M.thermoresistible__bu ---------------------------LFRSXXXGK--------------
:
MSMEG_0891|M.smegmatis_MC2_155 REGYPYDERMHRADYEEQKRLLQIELLKLQKWSQAHGHRHVIVFEGRDAA
Mvan_0772|M.vanbaalenii_PYR-1 RENYPYDERMTRPDYEEQKRLLQIELLKLQKWSQSHGHRHVIVFEGRDAA
MAB_4135c|M.abscessus_ATCC_199 RENYPYDERMSRHQYELEKRLLQIELLKLQNWSKRTGARHVILFEGRDAA
MMAR_1312|M.marinum_M KSAGAGRHKISKSVYEAELFRLQTEFVRLQEWVRHAGARVVVIFEGRDAA
MUL_2568|M.ulcerans_Agy99 KSAGAGRHKISKGVYEAELFRLQTEFVRLQEWVRHAGARVVVIFEGRDAA
MAV_4195|M.avium_104 ARAAV---KIPDAVYEAELFRLQTELVKLQEWVRHSGARLVVVFEGRDAA
Mb3261c|M.bovis_AF2122/97 -SAAPGRRKISDAVYQAELFRLQTEFVKLQEWARHSGARLVVIFEGRDGA
Rv3232c|M.tuberculosis_H37Rv -SAAPGRRKISDAVYQAELFRLQTEFVKLQEWARHSGARLVVIFEGRDGA
Mflv_4701|M.gilvum_PYR-GCK ------KSKLPGDVYEAELFRLQTELVKLQEWVRATGARVVVVFEGRDAA
TH_1923|M.thermoresistible__bu ------ADAPALQTERSARLAELQEMLYANHRVRGDRRSVLLVLQGMDTA
. *:: :. : :::::* * *
MSMEG_0891|M.smegmatis_MC2_155 GKGGTIKRFMEHLNPRGARVVALEKPTERERTQWYFQRYVEHLPAAGELV
Mvan_0772|M.vanbaalenii_PYR-1 GKGGTIKRFMEHLNPRGARVVALEKPTEKERTQWYFQRYVEHLPSAGEMV
MAB_4135c|M.abscessus_ATCC_199 GKGGTIKRFMEHLNPRGARVVALEKPTERERTQWYFQRYVPHLPAAGEMV
MMAR_1312|M.marinum_M GKGGAIKRITEYLSPRHAYVAALPVPNDRERGQWYYQRYIAHLPAKGEIV
MUL_2568|M.ulcerans_Agy99 GKGGAIKRITEYLSPRHAYVAALPVPNDRERGQWYYQRYIAHLPAKGEIV
MAV_4195|M.avium_104 GKGGAIKRITEYLSPRVARVAALPVPTDRERGQWYYQRYIAHLPSKGEIV
Mb3261c|M.bovis_AF2122/97 GKGGAIKRITEYLNPRVARIAALPAPTDRERGQWYYQRYIAHLPAKGEIV
Rv3232c|M.tuberculosis_H37Rv GKGGAIKRITEYLNPRVARIAALPAPTDRERGQWYYQRYIAHLPAKGEIV
Mflv_4701|M.gilvum_PYR-GCK GKGGAIKRVTEYLSPRVATIAALPAPTERERGQWYFQRYIQHLPTSGEIV
TH_1923|M.thermoresistible__bu GKGGIVKHVVGAVNPMGVRYRAFGPPTAEEKARHYLWRVRRALPPPGHLG
**** :*:. :.* . *: *. .*: : * * **. *.:
MSMEG_0891|M.smegmatis_MC2_155 LFDRSWYNRAGVERVMGYCTPKQHAEFIRQAPLFEQMLVNDGISLTKLWF
Mvan_0772|M.vanbaalenii_PYR-1 LFDRSWYNRAGVERVMGFCTPKQHAEFIRQVPLFEQMLVNDGVSLTKLWF
MAB_4135c|M.abscessus_ATCC_199 FFDRSWYNRAGVERVMGFCSDEQHSEFIHQAPLFEQMLVNDGISLTKLWF
MMAR_1312|M.marinum_M FFDRSWYNRAGIEKVMGFCTPQEHALFLRQTPIFEQMLIDDGILLRKYWF
MUL_2568|M.ulcerans_Agy99 FFDRSWYNRAGIEKVMGFCTPQEHALFLRQTPIFEQMLIDDGILLRKYWF
MAV_4195|M.avium_104 LFDRSWYNRAGIEKVMGFCTPQEYVLFLRQTPIFEQMLIDDGILLRKYWF
Mb3261c|M.bovis_AF2122/97 LFDRSWYNRAGVEKVMGFCTPQEYVLFLRQTPIFEQMLIDDGILLRKYWF
Rv3232c|M.tuberculosis_H37Rv LFDRSWYNRAGVEKVMGFCTPQEYVLFLRQTPIFEQMLIDDGILLRKYWF
Mflv_4701|M.gilvum_PYR-GCK LFDRSWYNRAGVEKVMGFCTPAEHALFLRQAPIFEQMLIEDGIILRKYWF
TH_1923|M.thermoresistible__bu VFDRSHYEDVLVVRVHNLVPPEVWSDRYDEINAFERELVDAGMTLVKVAL
.**** *: . : :* . . : **: *:: *: * * :
MSMEG_0891|M.smegmatis_MC2_155 SVTRSEQLTRFTIRQVDPVRQWKLSPTDLASLDKWDDYTAAKEEMFAWTD
Mvan_0772|M.vanbaalenii_PYR-1 SVTASEQRTRFTIRQVDPVRQWKLSPTDLASLDKWDDYTAAKEDMFAWTD
MAB_4135c|M.abscessus_ATCC_199 SVSAAEQRTRFAIRQVDPVRQWKLSPMDLASLDKWDAYTKAKEEMFSLTD
MMAR_1312|M.marinum_M SVSDEEQLHRFKARQTDPVRQWKLSPMDLESVYRWEDYSRAKDEMMVHTD
MUL_2568|M.ulcerans_Agy99 SVSDEEQLHRFKARQTDPVRQWKLSPMDLESVYRWEDYSRAKDEMMVHTD
MAV_4195|M.avium_104 SVSEAEQLRRFKARLKDPVRRWKLSPIDLESVYRWEDYSRAKDEMMVHTD
Mb3261c|M.bovis_AF2122/97 SVSDAEQLRRFKARRNDPVRQWKLSPMDLESVYRWEDYSRAKDEMMVHTD
Rv3232c|M.tuberculosis_H37Rv SVSDAEQLRRFKARRNDPVRQWKLSPMDLESVYRWEDYSRAKDEMMVHTD
Mflv_4701|M.gilvum_PYR-GCK SVSGEEQLRRFKSRHSDPVRRWKLSPMDLESVYRWEDYSRAKDEMMAHTD
TH_1923|M.thermoresistible__bu FISPAEQRKNLLARLEDPAKHWKYSPSDVDERRHWPAYQAAYQDMLDRTS
:: ** .: * **.::** ** *: . :* * * ::*: *.
MSMEG_0891|M.smegmatis_MC2_155 TEIAPWTVVKSNDKKRARINAMRYVLGKFDYDNKDHEVVGQAD-PLIVG-
Mvan_0772|M.vanbaalenii_PYR-1 TEAAPWTVVKSNDKKRARINAMRHVLSKFDYDNKDHEVVGRPD-PLIVG-
MAB_4135c|M.abscessus_ATCC_199 TDHAPWIVVKSNDKKRARVNAMRHVLGKFDYDDKDLDVVGQAD-PLILG-
MMAR_1312|M.marinum_M TPVSPWYVVESDIKKHARLNMMAHLLSTIDYRPVEMPKVNLPDQPIVTGN
MUL_2568|M.ulcerans_Agy99 TPVSPWYVVESDIKKHARLNMMAHLLSTIDYRPVEMPKVNLPDQPIVTGN
MAV_4195|M.avium_104 TPESPWYVVESDIKKHARLNMMAHLLSTIPYHAVEAPPVKLPRRPVVTGN
Mb3261c|M.bovis_AF2122/97 TPVSPWYVVESDIKKHARLNMMAHLLSTIDYADVEKPKVKLPPRPLVSGN
Rv3232c|M.tuberculosis_H37Rv TPVSPWYVVESDIKKHARLNMMAHLLSTIDYADVEKPKVKLPPRPLVSGN
Mflv_4701|M.gilvum_PYR-GCK TPLSPWYVVESDIKKHARLNMIAHLLSTIDYYDVEAPKVTLPKKVVCSAD
TH_1923|M.thermoresistible__bu TVYAPWFVVPGDRRWYSRLAVTELLIDALAGMGLSWPPADFDVEAERNRL
* :** ** .: : :*: ::. : . .
MSMEG_0891|M.smegmatis_MC2_155 -----RALSD--------------
Mvan_0772|M.vanbaalenii_PYR-1 -----RALSD--------------
MAB_4135c|M.abscessus_ATCC_199 -----RALTD--------------
MMAR_1312|M.marinum_M YKRPPRELSKYVEDYASTLIGR--
MUL_2568|M.ulcerans_Agy99 YKRPPRELSKYVEDYASTLIGR--
MAV_4195|M.avium_104 YQRPPRELSRYVDDYAATLI----
Mb3261c|M.bovis_AF2122/97 YRRPPRELSTYVDDYVATLIAR--
Rv3232c|M.tuberculosis_H37Rv YRRPPRELSTYVDDYVATLIAR--
Mflv_4701|M.gilvum_PYR-GCK YQRPPREASTYVDDHVASLMGDRE
TH_1923|M.thermoresistible__bu LRA---------------------