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TGPLHAGSVVDAIAADMRSANYTTDGVADLLGADAGAAFSRGLWWSALRATDWAAADRQRLATLIRLFLL GTDEPRDRVGRAVPTSDVDALIDNGVLEQTPDGALRAALDIRPTSDGAADFLVVSDQDAALRAGPVRRDH VLGIGGASVSLAHAVVRDPVGRALDLGTGCGIQALHLEAHCDEIVATDTNPRALALAAATARLNGMSWDL RCGSMFEPVAGERFDLIVSNPPFVVGTGSLDYIYRDSGMAGDGLCQNLIAQVRDHLRPGGTAQIMANWIV RDPQNWQERVHGWLADTGLHAWVVQREFADPVSYVSLWTSDAGESPEQAARRGGEWLDWFDAEGIAGVGM GMITLRAPRDGETRSPDQVVEEITGAGEALTGPEVGAFFARREYLDRTGDEQLLAAKLSTAPVFLEEQSL PGPDGWQVVGSAVRRPGGPAAVIGVDEVSRALFAGCRGEVPLGTLIELLAGYHGVDADALADAAMPVVRE AIGRGILYEAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4693 | - | - | 100% (502) | methyltransferase small |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_0427 | - | 4e-08 | 29.95% (187) | methylase, putative |
| M. smegmatis MC2 155 | MSMEG_1892 | - | 0.0 | 73.68% (494) | transferase |
| M. thermoresistible (build 8) | TH_0663 | - | 0.0 | 74.70% (502) | transferase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_1773 | - | 0.0 | 85.63% (501) | methyltransferase small |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4693|M.gilvum_PYR-GCK --------MTGPLHAGSVVDAIAADMRSANYTTDGVADLLGADAGAAFSR
Mvan_1773|M.vanbaalenii_PYR-1 --------MSHPLQSGAVVDALAADLRSAQYTTDGVAELLGADAGAAFSR
TH_0663|M.thermoresistible__bu MAVTETASNRAPLQSTAVIDAIGADLRSAGYTTDGVTDFFGPEVGAAFDR
MSMEG_1892|M.smegmatis_MC2_155 --------MSGEIDG-AVIDAIGADFRAAGYTVDGVAELLGEQADAALLR
MAV_0427|M.avium_104 --------------------------------------------------
Mflv_4693|M.gilvum_PYR-GCK GLWWSALRATDWAAAD----RQRLATLIRLFLLGTDEPRDRVGRAVPTSD
Mvan_1773|M.vanbaalenii_PYR-1 GLWWSALRATDRADAG----HQRLATLVRLFLLGTDEPRERVGHAMPGAG
TH_0663|M.thermoresistible__bu GLWWPALRATDRALAAGAPDQHRLAVLIRLFLLGTDEPRERVESALPGVG
MSMEG_1892|M.smegmatis_MC2_155 GVWWPALHATRKVPPH----RQRLAALVCLFLLGTEEPRDAVEAAFPSAG
MAV_0427|M.avium_104 -----------------------------------------MTTTYP---
: : *
Mflv_4693|M.gilvum_PYR-GCK VDALIDNGVLEQTPDGALRAALDIRPTSDGAADFLVVSDQDAALRAGPVR
Mvan_1773|M.vanbaalenii_PYR-1 VDALIDNGVVEPAGPDSVRAALDIRPHSDGARDFLVVSDQDSALRSGPVR
TH_0663|M.thermoresistible__bu VEDLADNGVIEPTGAGEWRSLLDIRPHSDGVRDFLVVADQDAALRGGPVA
MSMEG_1892|M.smegmatis_MC2_155 VDAMVANGVLDVTEGGALRAALDIRPHSDGTHDFFVVSDQDAVVRSGPLR
MAV_0427|M.avium_104 -------------EPAVLPAHNVYQPQED-----------------SRLL
: :* .* . :
Mflv_4693|M.gilvum_PYR-GCK RDHVLGIGGASVSLAHAVVRDPVGRALDLGTGCGIQALHLEAH-CDEIVA
Mvan_1773|M.vanbaalenii_PYR-1 HDHVLGIGGASVSLAHAVVRSPVGRALDLGTGCGIQALHLDAH-CDEVVA
TH_0663|M.thermoresistible__bu PDHVLGIGGASASLARATIRTPVGRALDLGTGCGVQALHLSAH-CAEVVA
MSMEG_1892|M.smegmatis_MC2_155 HDHVLGIGGASVSLARAVMRTPADRVLDLGTGCGIQALHLDAH-SDHIVA
MAV_0427|M.avium_104 VDVMHGTG-----------LIPGRRVLDLCTGSGFVAIAAAEMGCASVTA
* : * * * *.*** **.*. *: . :.*
Mflv_4693|M.gilvum_PYR-GCK TDTNPRALALAAATARLNGMSWDLRCGSMFEPVAGERFDLIVSNPPFVVG
Mvan_1773|M.vanbaalenii_PYR-1 TDTNPRALALAAATARLNGMSWDLRCGSLFEPVAGERFDLIVSNPPFVVG
TH_0663|M.thermoresistible__bu TDTNERALALAAATARLNGMSWDLRCGSLFEPVAGERFDLIVANPPFVVG
MSMEG_1892|M.smegmatis_MC2_155 TDTNARALALAAATARLNGMSWDLRHGSLFEPVAGERFDLIVSNPPFVVG
MAV_0427|M.avium_104 FDKCPHAVRCARENAALAGVDVDVREGSWLAAVDCAPFDVVVSNPPYVPT
*. :*: * .* * *:. *:* ** : .* **::*:***:*
Mflv_4693|M.gilvum_PYR-GCK TGSLDYIYRDSGMAGDGLCQNLIAQVRDHLRPGGTAQIMANWIVRDPQN-
Mvan_1773|M.vanbaalenii_PYR-1 TGSLDYIYRDSGMVGDALCQSMIEQVADHLEPGGTAQIMANWIVRDGEED
TH_0663|M.thermoresistible__bu DGVRRYLYRDSGFSGDALSRHLVEQVPEYLEPGGTAQIMANWIVRDGQD-
MSMEG_1892|M.smegmatis_MC2_155 SGARDYIYRDSGMAGDTVCQKLIEQVGDHLNPGGTAHIMANWIVKRDTD-
MAV_0427|M.avium_104 P------------------------------PGAVLDELG----------
**.. . :.
Mflv_4693|M.gilvum_PYR-GCK --WQERVHGWLADTGLHAWVVQREFADPVSYVSLWTSDAGESPEQAARRG
Mvan_1773|M.vanbaalenii_PYR-1 GGWRDRVRGWLAGTGLHAWVVQREFADPISYVSLWTSDAGESPEQAARRG
TH_0663|M.thermoresistible__bu --WRDRVREWLAGTGLHAWVVQRELADPVSYISLWTSDAGESPRQAARRG
MSMEG_1892|M.smegmatis_MC2_155 --WRDRVAGWLAGTGLHAWVVQRELADPISYISLWLADAGETPQQAARRG
MAV_0427|M.avium_104 -----------------------PVTGPS-----WAWNAGRDGR------
.:.* * :**. .
Mflv_4693|M.gilvum_PYR-GCK GEWLDWFDAEGIAGVGMGMITLRAPRDGETRSPDQVVEEITGAGEALTGP
Mvan_1773|M.vanbaalenii_PYR-1 GQWLDWFDAEGIAGVGMGMVTLRAPRVGETRPPDQVLEEITGADEALTGP
TH_0663|M.thermoresistible__bu AQWLDWFDEQGITAVGMGMIILRAPRRGDDRPPELVFDEITAPDQGLTGP
MSMEG_1892|M.smegmatis_MC2_155 GEWLEWFTEQDIAGIGMGLILLRAPAGGE--PPEQIFEEITGADELVTGT
MAV_0427|M.avium_104 ----------------------------------LVLDPLCESAP-----
:.: : .
Mflv_4693|M.gilvum_PYR-GCK EVGAFFARREYLDRTGDEQLLAAKLSTAPVFLEEQSLPGPDGWQVVGSAV
Mvan_1773|M.vanbaalenii_PYR-1 EVEAFLARREYLHDTGDEQLLAARLSTAPVFLEEQSLPGPDGWQVIGAAV
TH_0663|M.thermoresistible__bu EVEAFFARREYLHRTSDDELLAARLSTAPVFLEEQSLPGPDGWQVVGAAV
MSMEG_1892|M.smegmatis_MC2_155 EVEAFFARRAYLRDTSDEQLLAARLSTAPVFLEEQSLPGPDGWQQVGAAV
MAV_0427|M.avium_104 ---------KLLRDGGSLLLVHSALAGVQQSLDSLKWAGMDAKVIASKWI
* .. *: : *: . *:. . .* *. . :
Mflv_4693|M.gilvum_PYR-GCK RRPGGPAAVIGVDEVSRALFAGCRGEVPLGTLIELLAGYHGVDADALADA
Mvan_1773|M.vanbaalenii_PYR-1 RRPGGPGAVIGVDEVSRALFAGCRGEVPLGTLIELLASFHGVDADALATA
TH_0663|M.thermoresistible__bu RRPGGPGAVLGVDEVVRALLAGCRGEVPLGVLIHLLAAHHGVDADALAGA
MSMEG_1892|M.smegmatis_MC2_155 RRPGGPGAVIGVDDVMRALLAGCRGEVPLGMLIDLLAAHHGVDANALAEA
MAV_0427|M.avium_104 P--------FGPVMLSRAHWLEDVGLIPRGRREEELIVIRAEKR------
:* : ** * :* * . * :. .
Mflv_4693|M.gilvum_PYR-GCK AMPVVREAIGRGILYEAG
Mvan_1773|M.vanbaalenii_PYR-1 ALPVVREAIGRGILYQAQ
TH_0663|M.thermoresistible__bu ALPVVREAIGRGILYQAE
MSMEG_1892|M.smegmatis_MC2_155 ALPEVRDAIARGILYQAQ
MAV_0427|M.avium_104 ------------------