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VTREPTFVFAGPDGVVVGEGVHTAFPHIADARAALASHSSPIVVGALPFDLSRPAALMRPQSVRFTDVMP EGPGRELASTEITETSPDADEHRRRIGVALARLRDPADPLDKVVLARALLLTAQGRLDARTVLDRLASAD AQATKYLVDLSAAGEGYSGTALVGASPELLVARHGRHVLCRPFAGSAPRRPDPEDDAASGAALVESDKNR HEHQLVVDALRAALEPLCTDLQIAPRPQLTRTAAVWHLYTPITATLRERSTTALDLAVALHPTPAVGGSP TDRAVALIDELEGDRGFYAGAVGWCDQRGDGRWVVSIRCAQLSADRHTALAHSGGGIVAASDPDNELDET TTKFRTILSALGVES
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4680 | - | - | 100% (365) | isochorismate synthase |
| M. gilvum PYR-GCK | Mflv_3602 | - | 3e-22 | 32.35% (204) | anthranilate synthase component I |
| M. gilvum PYR-GCK | Mflv_1926 | - | 2e-17 | 35.32% (201) | para-aminobenzoate synthase component I |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3241 | entC | 1e-121 | 62.88% (361) | isochorismate synthase |
| M. tuberculosis H37Rv | Rv3215 | entC | 1e-121 | 62.88% (361) | isochorismate synthase |
| M. leprae Br4923 | MLBr_00808 | entC | 1e-121 | 61.50% (361) | putative isochorismate synthase |
| M. abscessus ATCC 19977 | MAB_3535 | - | 1e-95 | 50.83% (360) | isochorismate synthase EntC |
| M. marinum M | MMAR_1342 | entC | 1e-124 | 63.43% (361) | isochorismate synthase EntC |
| M. avium 104 | MAV_4163 | - | 1e-126 | 64.19% (363) | isochorismate synthase DhbC |
| M. smegmatis MC2 155 | MSMEG_1925 | - | 1e-130 | 65.56% (360) | isochorismate synthase DhbC |
| M. thermoresistible (build 8) | TH_0672 | entC | 1e-111 | 73.14% (283) | PROBABLE ISOCHORISMATE SYNTHASE ENTC (ISOCHORISMATE |
| M. ulcerans Agy99 | MUL_2537 | entC | 1e-123 | 62.88% (361) | isochorismate synthase EntC |
| M. vanbaalenii PYR-1 | Mvan_1787 | - | 1e-176 | 82.97% (364) | isochorismate synthases |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4680|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1787|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1925|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1342|M.marinum_M --------------------------------------------------
MUL_2537|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00808|M.leprae_Br4923 MAIRRGRNRASTFGCTELELTDTGRAQAKLAERALAEQKLVDPMMASNPR
Mb3241|M.bovis_AF2122/97 --------------------------------------------------
Rv3215|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4163|M.avium_104 --------------------------------------------------
TH_0672|M.thermoresistible__bu --------------------------------------------------
MAB_3535|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4680|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1787|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1925|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1342|M.marinum_M --------------------------------------------------
MUL_2537|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00808|M.leprae_Br4923 QCDLVTAKLAGLTVDKVSPLLAECTYGSYEDLTTAKTREAEPAWLAWTHR
Mb3241|M.bovis_AF2122/97 --------------------------------------------------
Rv3215|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4163|M.avium_104 --------------------------------------------------
TH_0672|M.thermoresistible__bu --------------------------------------------------
MAB_3535|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4680|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1787|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1925|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1342|M.marinum_M --------------------------------------------------
MUL_2537|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00808|M.leprae_Br4923 YPRGEKRLASQRTCRPGRRYGVRALGVTDHVVRQPWPPLLGGDHTLDRAA
Mb3241|M.bovis_AF2122/97 --------------------------------------------------
Rv3215|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4163|M.avium_104 --------------------------------------------------
TH_0672|M.thermoresistible__bu --------------------------------------------------
MAB_3535|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4680|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1787|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1925|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_1342|M.marinum_M --------------------------------------------------
MUL_2537|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00808|M.leprae_Br4923 ICRGPALRYAHQLDWDVRVRVRATATTHAWVAWLATTGRTRVNINNDDDK
Mb3241|M.bovis_AF2122/97 --------------------------------------------------
Rv3215|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4163|M.avium_104 --------------------------------------------------
TH_0672|M.thermoresistible__bu --------------------------------------------------
MAB_3535|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_4680|M.gilvum_PYR-GCK ------------MTREPTFVFAGPDGVVVGEGVHTAFPHIADARAALASH
Mvan_1787|M.vanbaalenii_PYR-1 ------------MTREPAFVFAGPDGVIVGEGVHTAFPRIADARAALASH
MSMEG_1925|M.smegmatis_MC2_155 ------------MS-APSFVFAGPSGVLIGEGVQTGFATIAGARAALTSG
MMAR_1342|M.marinum_M -----------MRASEPPFALCGPRGNLIAEGVRTSYSEIAAAQAALRSG
MUL_2537|M.ulcerans_Agy99 -----------MRASEPPFALCGPRGNLIAEGVRTSYSEIAAAQAALRSG
MLBr_00808|M.leprae_Br4923 RRPVAQERAEQMRPSEPPFALCGPRGTLVADGVHTRYDDVYLAQAALRSG
Mb3241|M.bovis_AF2122/97 -----MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSG
Rv3215|M.tuberculosis_H37Rv -----MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSG
MAV_4163|M.avium_104 ------------MNDEPTFALCGPTQTLVADGVRRSYRDVAAAQAALRSQ
TH_0672|M.thermoresistible__bu --------------------------------------------------
MAB_3535|M.abscessus_ATCC_1997 -------MTATDSPARPHFVMSRAADALYAYGRDATYDDVFTAAEALRTG
Mflv_4680|M.gilvum_PYR-GCK SSPIVVGALPFDLSRPAALMRPQSVRFTDVMPEGPGRELASTEITETSPD
Mvan_1787|M.vanbaalenii_PYR-1 STPIIVGALPFDITKPAALIRPQSVRFTDALPVWPPREMSTAQITGTTPD
MSMEG_1925|M.smegmatis_MC2_155 AADLVVGALPFDLTGPAALHAPASARVAGALPDWPTGTPPVLRTRETLPS
MMAR_1342|M.marinum_M SAPMLLGALPFDVSQPAALMVPTSVRRETGLPDWPTEAPPRVRISAAVPP
MUL_2537|M.ulcerans_Agy99 SAPMLLGALPFDVSQPAALMVPTSVRRETGLPDWPTEAPPRVRISAAVPP
MLBr_00808|M.leprae_Br4923 VTPILLGALPFDAESPAALMAPSAVLRTDTLPNWQTGPLPTLRITAAVPT
Mb3241|M.bovis_AF2122/97 TAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPP
Rv3215|M.tuberculosis_H37Rv TAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPP
MAV_4163|M.avium_104 EVSIVLGALPFDVRRPAALLTPDTVSVSDGPPDWPARKLPSMRVAAALPP
TH_0672|M.thermoresistible__bu -----------------------------------------XRIVRTEPA
MAB_3535|M.abscessus_ATCC_1997 RHHMLVGALPFDTSRPVALTAPVTVQR--GLPQEFYGAMPNTQVTQQVPA
. *
Mflv_4680|M.gilvum_PYR-GCK ADEHRRRIGVALARLRDPADPLDKVVLARALLLTAQGRLDARTVLDRLAS
Mvan_1787|M.vanbaalenii_PYR-1 ADEHRRRIGMALARLRDPDDALQKVVLARALRLTADGRLDARTLLNRLAA
MSMEG_1925|M.smegmatis_MC2_155 GDVHRERVAEAVRRLRDADTPLDKVVLARALRLTAEAPWDPRTVLRRLAD
MMAR_1342|M.marinum_M LAEHRARITRARDELAAPQGLLHKVVLARALQLTAETALDARVVLRRLMA
MUL_2537|M.ulcerans_Agy99 LAEHRARITRARDQLAAPQGLLHKVVLARALQLTAETALDPRVVLRRLMA
MLBr_00808|M.leprae_Br4923 RANYRVWISNAREQLTAPGNSLHKVVLARALQLVADAPLDGRAILRRLVT
Mb3241|M.bovis_AF2122/97 PADYLTRIGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVV
Rv3215|M.tuberculosis_H37Rv PADYLTRIGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVV
MAV_4163|M.avium_104 PIDYRDRICRAREQLAATDNPLHKVVLARALHLVADAPLDARTILRRLIA
TH_0672|M.thermoresistible__bu PEEHRARIETALQLLTDPRHGLHKVVLARALHLHADAPLDAGVVARRLAA
MAB_3535|M.abscessus_ATCC_1997 PSEHLRRVTEAVEVLRS-DAGLAKVVLARVLELRAESPVDPLVLTHRLIR
: : * * * ******.: * *: * .: **
Mflv_4680|M.gilvum_PYR-GCK ADAQATKYLVDLSAAGEGYSGTALVGASPELLVARHGRHVLCRPFAGSAP
Mvan_1787|M.vanbaalenii_PYR-1 NDAQATKYLVDLSAAGEGYSGAALIGASPELLVARHGRQVICRPFAGSAP
MSMEG_1925|M.smegmatis_MC2_155 ADPAATVYLADLSPAGDPHTGTVLVGASPELLVARDGDEVICRPFAGSAP
MMAR_1342|M.marinum_M ADPTSYGYLVDLTAAGDCYTGAALVGASPELLVARFGDQVTCQPFAGSAP
MUL_2537|M.ulcerans_Agy99 ADPTSYGYLVDLTAAGDCYTGAALVGASPELLVARFGDQVTCQPFAGSAP
MLBr_00808|M.leprae_Br4923 ADPTAYGYLVDLTAAGGQYAGVALVGASPELLVSRFGDRVVCRPFAGSAP
Mb3241|M.bovis_AF2122/97 ADPTAYGYLVDLTSAGNDDTGAALVGASPELLVARSGNRVMCKPFAGSAP
Rv3215|M.tuberculosis_H37Rv ADPTAYGYLVDLTSAGNDDTGAALVGASPELLVARSGNRVMCKPFAGSAP
MAV_4163|M.avium_104 ADPGAYGYLVDLSAAGHDHAGVALVGASPELLVARTGDRVECRPFAGSAP
TH_0672|M.thermoresistible__bu ADATANTFLVDLSAAGGRHRGTALVGASPELLVDRRGELVRCRPFAGSAP
MAB_3535|M.abscessus_ATCC_1997 NDPDANSFCVDLSPAGNRFRGHTMVGCSPELLVERRGDMVICHPFAGSAP
*. : : .**:.** * .::*.****** * * * *:*******
Mflv_4680|M.gilvum_PYR-GCK RRPDPEDDAASGAALVESDKNRHEHQLVVDALRAALEPLCTDLQIAPRPQ
Mvan_1787|M.vanbaalenii_PYR-1 RLDDPAADAANGAALADSEKNRHEHQLVVDALRSALEPLCTDLQIADRPQ
MSMEG_1925|M.smegmatis_MC2_155 RSADLETDRANAAALAASGKNRHEHELVVDVMRKALDPLCVDLQIAAQPE
MMAR_1342|M.marinum_M RSADPEIDAANATALAGSAKNRHEHQLVIDTMREALEPLCDELKIAPEPE
MUL_2537|M.ulcerans_Agy99 RSADPEIDAANATALAGSAKNQHEHQLVIDTMREALEPLCDELKIAPEPE
MLBr_00808|M.leprae_Br4923 RATNPEVDSANSAALAGSIKNRHEHQLVIDAIRAALEPVCDNLTIAPEPE
Mb3241|M.bovis_AF2122/97 RAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTIPAQPQ
Rv3215|M.tuberculosis_H37Rv RAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTIPAQPQ
MAV_4163|M.avium_104 RAADPDTDAANGAALASSAKNRHEHQLVIETIRAALEPLCDDLSIAAQPQ
TH_0672|M.thermoresistible__bu RLADPEADAASGAALAASAKNLHEHQLVVDAIRQALGPLCVDLQIAPEPQ
MAB_3535|M.abscessus_ATCC_1997 RSSDPSQDRRTGEDLAGSHKNRHEHSVVIDQLREDLASLCVDVQVPPEPT
* : * .. *. * ** ***.:*:: :* * .:* :: :. .*
Mflv_4680|M.gilvum_PYR-GCK LTRTAAVWHLYTPITATLRERSTTALDLAVALHPTPAVGGSPTDRAVALI
Mvan_1787|M.vanbaalenii_PYR-1 LSRTAAVWHLYTPMSGVLREKSLTALDLAVALHPTPAVGGSPTDEAVAFI
MSMEG_1925|M.smegmatis_MC2_155 LHATDALWHLSTPIRGRLRDKAITAIDLAVALHPTPAVGGVPTDLAASLI
MMAR_1342|M.marinum_M LTGTAAVWHLCTPVIGKLRDTATTAIDLALALHPTPAVGGVPTNAASELI
MUL_2537|M.ulcerans_Agy99 LTGTAAVWHLCTPVIGKLRDTATTAIDLALALHPTPAVGGVPTNAASELI
MLBr_00808|M.leprae_Br4923 LSRTAAVWHLCTPISGRLRDTSITAIDLALMLHPTPAVGGVPAEAASELI
Mb3241|M.bovis_AF2122/97 LNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELI
Rv3215|M.tuberculosis_H37Rv LNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELI
MAV_4163|M.avium_104 LSRTATVWHLCTPISGRLRDKSTTAIDLALALHPTPAVGGVPTDAAVELI
TH_0672|M.thermoresistible__bu LSRTAAVWHLSTPITARLREPSTTALDLALAMHPTPAVGGTPTDVAAATI
MAB_3535|M.abscessus_ATCC_1997 LSRTAALWHLSTSISARLRQSSTTALDLALALHPTPAVCGTPTEAAADLI
* * ::*** *.: . **: : **:***: :****** * *:. * *
Mflv_4680|M.gilvum_PYR-GCK DELEGDRGFYAGAVGWCDQRGDGRWVVSIRCAQLSADRHTALAHSGGGIV
Mvan_1787|M.vanbaalenii_PYR-1 NDVEGDRGFYAGAVGWCDQRGDGRWVVSIRCAQLSADRRTAVAHSGGGIV
MSMEG_1925|M.smegmatis_MC2_155 TELEGDRGFYAGAVGWCDSAGNGRWVVSIRCAVLSADRRVALANAGGGIV
MMAR_1342|M.marinum_M ASLEGDRGFYAGTVGWCDAGGDGYWVVSIRCAQLSADRRTALAHAGGGIV
MUL_2537|M.ulcerans_Agy99 ASLEGDRGFYAGTVGWCDAGGDGYWVVSIRCAQLSADRRTALAHAGGGIV
MLBr_00808|M.leprae_Br4923 AALEGDRGFYAGAVGWCDARGDGHWVVSIRCAQLSADRRIAFAHAGGGIV
Mb3241|M.bovis_AF2122/97 AELEGDRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHAGGGIV
Rv3215|M.tuberculosis_H37Rv AELEGDRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHAGGGIV
MAV_4163|M.avium_104 AELEGDRGFYAGAVGWCDARGDGRWVVSIRCAQLSADRRSALARAGGGIV
TH_0672|M.thermoresistible__bu SRIEGDRGFYAGAVGWCDARGDGRWVVSIRCAQLSADRRSAVAHAGGGIV
MAB_3535|M.abscessus_ATCC_1997 SRIEGDRGFYAGAIGWCDRNGDGRWAVTIRCAELSADGTAIRAYAGGGLV
:*********::**** *:* *.*:**** **** * :***:*
Mflv_4680|M.gilvum_PYR-GCK AASDPDNELDETTTKFRTILSALGVES-
Mvan_1787|M.vanbaalenii_PYR-1 AESDPDDEVDETTTKFRTILSALGVEQ-
MSMEG_1925|M.smegmatis_MC2_155 AESDPDDEVDETTTKFRTILTGLGVQ--
MMAR_1342|M.marinum_M AESNPDDEVDETTTKFATILTALGVKQ-
MUL_2537|M.ulcerans_Agy99 AESNPDDEVDETTTKFATILTALGVKQ-
MLBr_00808|M.leprae_Br4923 AESDPDDEVDETTAKFATILNALGVKQ-
Mb3241|M.bovis_AF2122/97 AESDPDDELEETTTKFATILTALGVEQ-
Rv3215|M.tuberculosis_H37Rv AESDPDDELEETTTKFATILTALGVEQ-
MAV_4163|M.avium_104 AESDPDDEVAETTTKFATILNALDVR--
TH_0672|M.thermoresistible__bu AESDPDDELTETTTKFTTMLKALGVQP-
MAB_3535|M.abscessus_ATCC_1997 AESDPQDELSETTVKFRTVLAALGAKID
* *:*::*: ***.** *:* .*...