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TAPTFADLGVPAPLVKALAERGIAEPFPIQAATLPDSLAGRDVLGRGKTGSGKTLAFSIPLVAALTGIRR QASRPSGLVLAPTRELATQITAALEPMATAAGLRVTTIYGGVSQGRQVSALRGGIDIVVACPGRLEDLMQ QKVISLDNVTVTVLDEADHMADLGFLPGVTRILAATPRGGQRLLFSATLDNGVDKLVQRFLDNPVLHSVN EAAEAPAQMTHHVFHVGGVQEKKDLVHQLASGTGRRILFMRTKHQARKLAKQLTESGVPSVDLHGNLSQP ARERNLAAFSSGEARVLVATDIAARGVHVDDVELVVHVDPPMEHKAYLHRSGRTARAGSDGDVVTVVLPE QRRDTQQLLRKAGITVRPRDVHAKSSEVQALVGEIAPLRAPAPVAQPAAKKPDHGRGSRNGGSGGHGRSG GEHQRRGGGGGRGRDGQGGGSSSTSRGPRRRGQRPAGQSQRGVNTGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3959 | - | - | 100% (468) | DEAD/DEAH box helicase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4676 | - | 1e-72 | 36.31% (493) | DEAD/DEAH box helicase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2225 | - | 2e-62 | 38.86% (350) | DEAD/DEAH box helicase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3237 | rhlE | 1e-70 | 37.90% (467) | ATP-dependent RNA helicase RhlE |
| M. tuberculosis H37Rv | Rv3211 | rhlE | 4e-71 | 38.12% (467) | ATP-dependent RNA helicase RhlE |
| M. leprae Br4923 | MLBr_00811 | rhlE | 3e-74 | 39.05% (461) | putative ATP-dependent RNA helicase |
| M. abscessus ATCC 19977 | MAB_2158c | - | 1e-157 | 66.21% (438) | ATP-dependent RNA helicase |
| M. marinum M | MMAR_4824 | rhlE1 | 1e-176 | 70.95% (444) | ATP-dependent RNA helicase, RhlE1 |
| M. avium 104 | MAV_2956 | - | 1e-172 | 69.35% (460) | ATP-dependent RNA helicase |
| M. smegmatis MC2 155 | MSMEG_1540 | - | 1e-132 | 55.63% (462) | ATP-dependent RNA helicase |
| M. thermoresistible (build 8) | TH_4173 | - | 1e-108 | 53.62% (401) | PUTATIVE ATP-dependent RNA helicase |
| M. ulcerans Agy99 | MUL_0393 | rhlE1 | 1e-173 | 70.27% (444) | ATP-dependent RNA helicase, RhlE1 |
| M. vanbaalenii PYR-1 | Mvan_2437 | - | 0.0 | 79.66% (472) | DEAD/DEAH box helicase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3959|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2437|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4824|M.marinum_M MLLTTLTVAFDGQHVVKRFFTPRARPAFGADAGAVRISAIDFAHRQFRHL
MUL_0393|M.ulcerans_Agy99 MLLTTLTVAFDGQHVVKRFFTPRARPAFGADAGAVRISAIDFAHRQFRHL
MAV_2956|M.avium_104 --------------------------------------------------
MAB_2158c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_1540|M.smegmatis_MC2_155 --------------------------------------------------
TH_4173|M.thermoresistible__bu --------------------------------------------------
Mb3237|M.bovis_AF2122/97 --------------------------------------------------
Rv3211|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00811|M.leprae_Br4923 --------------------------------------------MNRDSK
Mflv_3959|M.gilvum_PYR-GCK ----------------------MTAPTFADLGVPAPLVKALAERGIAEPF
Mvan_2437|M.vanbaalenii_PYR-1 ----------------------MTTPTFTDLGVPAPLVQSLSQRGITEPF
MMAR_4824|M.marinum_M VLTERAYLAAHSAEPILKDIKLTTGTTFADLGVGESLIEVLAARGISHPF
MUL_0393|M.ulcerans_Agy99 VLTERAYLAAHSAEPILKDIKLATGTTFADLGVGESLIEVLAARGISHPF
MAV_2956|M.avium_104 ---------------------MTTPKTFADLGVPARIVDALTARGITSPF
MAB_2158c|M.abscessus_ATCC_199 --------------------------------MPAPLVNVLTRGGIDAPF
MSMEG_1540|M.smegmatis_MC2_155 ---------------------MSAQKTFAELGLPAELVSTLAANGVTTPF
TH_4173|M.thermoresistible__bu --------------------------------------------------
Mb3237|M.bovis_AF2122/97 ----------------MTAVKHTTESTFAKLGARDEIVRALGEEGIKRPF
Rv3211|M.tuberculosis_H37Rv ----------------MTAVKHTTESTFAKLGVRDEIVRALGEEGIKRPF
MLBr_00811|M.leprae_Br4923 TPTQNRFSHRKAFHPHMTAPTSTAEPAFAKLGVRDEIVRALAERGIQQPF
Mflv_3959|M.gilvum_PYR-GCK PIQAATLPDSLAGRDVLGRGKTGSGKTLAFSIPLVAALTG--IRRQAS-R
Mvan_2437|M.vanbaalenii_PYR-1 PIQAATLPDALAGRDVLGRGKTGSGKTLAFSIPLVTALTG--RRSQPS-R
MMAR_4824|M.marinum_M PIQIETLPDTLGGRDVLGRGKTGSGKTLAFSLPMVSRLAG--RPRRPA-R
MUL_0393|M.ulcerans_Agy99 PIQIETLPDTLGGRDVLGRGKTGSGKTLAFSLPMVSRLAG--RPRRPA-R
MAV_2956|M.avium_104 PIQAETLPDTLAGRDVLGRGKTGSGKTLAFSIPLVGRLST--GNRRPA-R
MAB_2158c|M.abscessus_ATCC_199 PIQAATLPDTLGGRDVLARGKTGSGKTLGFSIPVVARIAD--GTRVPG-R
MSMEG_1540|M.smegmatis_MC2_155 PIQAATLPDSLNGRDVLGRGRTGSGKTYAFLLPLVARLATSGTPRDAG-K
TH_4173|M.thermoresistible__bu ---------------VLGRGRTGSGKSYAFLLPVVARLARQPRTRTPR-R
Mb3237|M.bovis_AF2122/97 AIQELTLPLALDGEDVIGQARTGMGKTFAFGVPLLQRITSGDGTRPLTGA
Rv3211|M.tuberculosis_H37Rv AIQELTLPLALDGEDVIGQARTGMGKTFAFGVPLLQRITSGDGTRPLTGA
MLBr_00811|M.leprae_Br4923 AIQELTLPLALAGDDVIGQARTGMGKTFAFGVPLLQRISVTTTARPLSGA
*:.:.:** **: .* :*:: ::
Mflv_3959|M.gilvum_PYR-GCK PSGLVLAPTRELATQITAALEPMATAA--------------GLRVTTIYG
Mvan_2437|M.vanbaalenii_PYR-1 PSGLVLAPTRELATQITATLQPLAAAN--------------GLRITTIFG
MMAR_4824|M.marinum_M PTGLVLAPTRELASQITATLQPLAAVN--------------GLRVTTIFG
MUL_0393|M.ulcerans_Agy99 PTGLVLAPTRELASQITATLQPLAAVN--------------GLRVTTIFG
MAV_2956|M.avium_104 PTGLVLAPTRELATQITATLEPLAAAC--------------GLRVSTIFG
MAB_2158c|M.abscessus_ATCC_199 PRALVLAPTRELATQISAVIEPLAAAY--------------RMKVTTIFG
MSMEG_1540|M.smegmatis_MC2_155 PRAVILAPTRELVTQIEASLAPLAAAT--------------GLRTVNIFG
TH_4173|M.thermoresistible__bu PRALILAPTRELVTQLATALAPLAAVT--------------GLRSVTVFG
Mb3237|M.bovis_AF2122/97 PRALVVVPTRELCLQVTDDLATAGKYLTAGPDTDDAAAVRRRLSVVSIYG
Rv3211|M.tuberculosis_H37Rv PRALVVVPTRELCLQVTDDLATAGKYLTAGPDTDDAAAVRRRLSVVSIYG
MLBr_00811|M.leprae_Br4923 PRGLVVVPTRELCLQVADDLATVAKYLTADDDN-------RRFSVVSIYG
* .:::.***** *: : . . : .::*
Mflv_3959|M.gilvum_PYR-GCK GVSQGRQVSALRGGIDIVVACPGRLEDLMQQKVISLDNVTVTVLDEADHM
Mvan_2437|M.vanbaalenii_PYR-1 GVSQSRQVAALRAGVDIVVACPGRLEDLMGQKLISLQDVTTTVLDEADHM
MMAR_4824|M.marinum_M GVPQGRQVTALNSGVDIVVACPGRLEDLMKQRLISLDSIEITVIDEADHM
MUL_0393|M.ulcerans_Agy99 GVPQGRQVTALNSGVDIVVACSGRLEDLMKQRLISLDSIEITVIDEADHM
MAV_2956|M.avium_104 GVSQHRQVTALKAGVDIVVACPGRLEDLMRQRLITLEAVRVTVIDEADHM
MAB_2158c|M.abscessus_ATCC_199 GVSQHRQVQALKAGVDIVVACPGRLDDLLKQGHLTLDGIEISVLDEADHM
MSMEG_1540|M.smegmatis_MC2_155 GVGAGPQIAALRRGVDIVIACPGRLEDHVQSRHADLSSVEVTILDEADHM
TH_4173|M.thermoresistible__bu GVGAQPQIQRLRAGVDIVLACPGRLEDLMSSGHVDLSGVEITVLDEADHM
Mb3237|M.bovis_AF2122/97 GRPYEPQIEALRAGADVVVGTPGRLLDLCQQGHLQLGGLSVLVLDEADEM
Rv3211|M.tuberculosis_H37Rv GRPYEPQIEALRAGADVVVGTPGRLLDLCQQGHLQLGGLSVLVLDEADEM
MLBr_00811|M.leprae_Br4923 GRAYEPQIEALQTGADVVVSTPGRLLDLCQQGHLQLSGLSVLVLDEADEM
* *: *. * *:*:. .*** * . * : ::****.*
Mflv_3959|M.gilvum_PYR-GCK ADLGFLPGVTRILAATPRGGQRLLFSATLDNGVDKLVQRFLDNPVLHSVN
Mvan_2437|M.vanbaalenii_PYR-1 ADLGFLPGVTRILAATPRGGQRLLFSATLDNGVDKLVQRFLNDPVLHSVN
MMAR_4824|M.marinum_M ADLGFLPGVTRILAATPSGGQRLLFSATLDNGVDKLVNRFLHDAVLHSVD
MUL_0393|M.ulcerans_Agy99 ADLGFLPGVTRILAATPSGGQRLLFSATLDNGVDKLVNRFLHDAVLHSVD
MAV_2956|M.avium_104 ADLGFLPGVTRILAATPNDGQRLLFSATLDNGVDKLVTRFLRDAVLHSVD
MAB_2158c|M.abscessus_ATCC_199 ADLGFLPVVTRLLAATPSSGQRLLFSATLDNDVDKLVKRFLHSPAEHSVD
MSMEG_1540|M.smegmatis_MC2_155 ADLGFLPGVKRLLDRTPKHCQRLLFSATLDAGVDVLVKRYLHDPVVHSVD
TH_4173|M.thermoresistible__bu ADLGFLPGVKRLLDRTPRDGQRLLFSATLDAGVDVLVRRYLDDPVVHSVD
Mb3237|M.bovis_AF2122/97 LDLGFLPDIERILRQIPADRQSMLFSATMPDPIITLARTFMVRPTHIRAE
Rv3211|M.tuberculosis_H37Rv LDLGFLPDIERILRQIPADRQSMLFSATMPDPIITLARTFMVRPTHIRAE
MLBr_00811|M.leprae_Br4923 LDLGFFPDIERLLGQIPTDRQSMLFSATMPDPIITLARTFMDQPIHIRAE
****:* : *:* * * :*****: : *. :: . .:
Mflv_3959|M.gilvum_PYR-GCK EAAE-APAQMTHHVFHVGGVQEKKDLVHQLASGTGR--RILFMRTKHQAR
Mvan_2437|M.vanbaalenii_PYR-1 EAAE-APAQMTHHVFHVGGVQEKKDLVHRLASGTGR--RILFMRTKHQAR
MMAR_4824|M.marinum_M SSDS-PVPQMVHHVFHVSGAAAKKDLVHRLASGTGR--RILFMRTKHQAR
MUL_0393|M.ulcerans_Agy99 SSDS-PVPQMVRHVFHVSGAAAKKDLVHRLASGTGR--RILFMRTKHQAR
MAV_2956|M.avium_104 EANS-PVSEMTHHVFHVDSAQAKKELVHRLASGTGR--RILFLRTKHQAR
MAB_2158c|M.abscessus_ATCC_199 PVDS-PVAAMTHHVFAVAGPDAKRELINTLASGTGR--RILFMRTKHHAK
MSMEG_1540|M.smegmatis_MC2_155 SAQS-PVSAMVHHVLHVD-NAARINVVADLAAAPGR--TIVFARTKHGAK
TH_4173|M.thermoresistible__bu SEQS-PVTDMAHHVLHVQ-PSARIDVLTDLAAAPGR--TIVFARTKHGAK
Mb3237|M.bovis_AF2122/97 APHSSAVHDATEQFVYRAHALDKVELVSRVLQARDRGATMIFTRTKRTAQ
Rv3211|M.tuberculosis_H37Rv APHSSAVHDATEQFVYRAHALDKVELVSRVLQARDRGATMIFTRTKRTAQ
MLBr_00811|M.leprae_Br4923 APHSLAVHDTTQQFVYRAHALDKVELISRILQARGRGATMIFTRTKRTAQ
. . ..:.. : ::: : . .* ::* ***: *:
Mflv_3959|M.gilvum_PYR-GCK KLAKQLTESGVPSVDLHGNLSQPARERNLAAFSSGEARVLVATDIAARGV
Mvan_2437|M.vanbaalenii_PYR-1 KLAKQLTDAGVPSVDLHGNLSQPARERNLAAFSSGEARVLVATDIAARGV
MMAR_4824|M.marinum_M KLAKQLTESGVPAVDLHGNLSQPARDRNLAAFSKGEARVLVATDIAARGV
MUL_0393|M.ulcerans_Agy99 KLAKQLTESGVPAVDLHGNLSQPARDRNLAAFSKGEARVLVATDIAARGV
MAV_2956|M.avium_104 KLARQLTESGVPSVDLHGNLSQPARERNLAMFAAGSARVLVATDIAARGV
MAB_2158c|M.abscessus_ATCC_199 RLARQLTQSGIPSVDLHGNLSQGARDRNLAAFANGEARVLVATDVAARGV
MSMEG_1540|M.smegmatis_MC2_155 NLTRQLNSRGISAVELHGNLSQNARTRNLTAFSDGSATVMVATDIAARGI
TH_4173|M.thermoresistible__bu KLARQLNSRGVRAVELHGNLAQNARTRNLTAFADGSATVLVATDIAARGI
Mb3237|M.bovis_AF2122/97 KVADELTERGFAVGAVHGDLGQLAREKALKAFRTGGIDVLVATDVAARGI
Rv3211|M.tuberculosis_H37Rv KVADELTERGFAVGAVHGDLGQLAREKALKAFRTGGIDVLVATDVAARGI
MLBr_00811|M.leprae_Br4923 KVTNELNERGFAVGAVHGDLGQIARENALEAFRTGNVDVLVATDVAARGI
.:: :*.. *. :**:*.* ** . * * * *:****:****:
Mflv_3959|M.gilvum_PYR-GCK HVDDVELVVHVDPPMEHKAYLHRSGRTARAGSDGDVVTVVLPEQRRDTQQ
Mvan_2437|M.vanbaalenii_PYR-1 HVDDVELVVHVDPPMEHKAYLHRSGRTARAGSDGDVVTVVLPEQRRDTQQ
MMAR_4824|M.marinum_M HVDGIELVVHIDPPAEHKAYLHRSGRTARAGNAGDVVTVVLPEQRKDTHA
MUL_0393|M.ulcerans_Agy99 HVDGIELVVHIDPPAEHKAYLHRSGRTARAGNAGDVVTVVLPEQRKDTHA
MAV_2956|M.avium_104 HVDEVELVVHIDPPSEHKSYLHRSGRTARAGSAGDVVTVVLPEQREHTRA
MAB_2158c|M.abscessus_ATCC_199 HVDDVALVVHVDPPAEHKAYLHRSGRTARAGGTGDVVTLVLPEQRRDVDA
MSMEG_1540|M.smegmatis_MC2_155 HVDDVSLVVHADPPVEHKAYLHRSGRTARAGNEGTVVTLMLDAQVHDVRN
TH_4173|M.thermoresistible__bu HVDDVGLVVHADPPVEHKAYLHRSGRTARAGASGTVVTLMLDDQVSDVRA
Mb3237|M.bovis_AF2122/97 DIDDVTHVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELPRWSM
Rv3211|M.tuberculosis_H37Rv DIDDVTHVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELPRWSM
MLBr_00811|M.leprae_Br4923 DIDDVTHVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELHRWET
.:* : *:: : * :.* *:** ***.*** * .**:: :
Mflv_3959|M.gilvum_PYR-GCK LLRKAGITVR-PRDVHAKSSEVQALVG----------EIAPLRAP-----
Mvan_2437|M.vanbaalenii_PYR-1 LLRRAGITVR-PSNVDANSAEVHALVG----------EVAPLRHV-----
MMAR_4824|M.marinum_M LMRRAGIRVT-PQEVTADSAAVHELVG----------DIAPYQAP-----
MUL_0393|M.ulcerans_Agy99 LMRRAGIRVT-PQEVTADSAAVHELVG----------DIAPYQAP-----
MAV_2956|M.avium_104 LMRKAGIDVA-PQRVTAGSEAVHALVG----------PIAPPKPP-----
MAB_2158c|M.abscessus_ATCC_199 LLRKAAIKAT-PRQVTADSVEVANLVG----------EVAPYVKP-----
MSMEG_1540|M.smegmatis_MC2_155 LTRKAGVKPT-ITRISGLDHPVLREIAPGERVFGEPIRTEPAATP----S
TH_4173|M.thermoresistible__bu LTRKAGVKPV-ITRFTGPQHPVLHQIAPGERIFTTPIGTAPPGTAPAGTD
Mb3237|M.bovis_AF2122/97 IDQALGLGSPDPAETYSNSPHLYAELAIP--------ATAGGTVG-----
Rv3211|M.tuberculosis_H37Rv IDQALGLGSPDPAETYSNSPHLYAELAIP--------ATAGGTVG-----
MLBr_00811|M.leprae_Br4923 IDKALGLGTPDPAETYSNSPHLYTELAIP--------AEASGTVG-----
: : .: . . : :.
Mflv_3959|M.gilvum_PYR-GCK APVAQPAAKKPDHGRGSRNGGSGGHGRSGGEHQRRGGGGGRGRDGQGGGS
Mvan_2437|M.vanbaalenii_PYR-1 APKAVQATKP-----AVRNQ----------DH--------RGADPRRGGP
MMAR_4824|M.marinum_M APKQVAAPKKAGAPKKGAAP------------KKGAAPRNG--AAPHGSP
MUL_0393|M.ulcerans_Agy99 APKQVAAPKKAGAPKKGAAP------------KKGAAPRNG--AAPHGSP
MAV_2956|M.avium_104 AAAGVPSHPAGPHRPAAAGQ------------RRRRSGRSARTTAAHAAV
MAB_2158c|M.abscessus_ATCC_199 VPAQKTSQPAATNNRPARRVR-------------------KHTEAGEGRP
MSMEG_1540|M.smegmatis_MC2_155 RPRS-TQPRRSRPQGSG----------------------RPGRSGHGAQS
TH_4173|M.thermoresistible__bu RPXXXXAAASAAPAGRGAAAPGDDDRTAAAGHHHDDHHDHPGRTPAGDLL
Mb3237|M.bovis_AF2122/97 -PARKSQGRRRDTDCDGQK---------------------TAQHAR----
Rv3211|M.tuberculosis_H37Rv -PARKSQGRRRDTDCDGQK---------------------TAQHAR----
MLBr_00811|M.leprae_Br4923 -TPRKAQVKRRKTDRDGDKSG------------------TSAQAAKAART
.
Mflv_3959|M.gilvum_PYR-GCK SSTSRGPRRRGQRPAGQSQRGVNTGG------------------------
Mvan_2437|M.vanbaalenii_PYR-1 SRSARGPRRR--RPRQGTQRAANTGG------------------------
MMAR_4824|M.marinum_M RPRSAGSGGRRRGPRPGRMRQETS--------------------------
MUL_0393|M.ulcerans_Agy99 RPRSAGSGSLRRGPRPGRMRQETS--------------------------
MAV_2956|M.avium_104 PHRPAAPARRPDRRRASRAQGSAG--------------------------
MAB_2158c|M.abscessus_ATCC_199 ARTPRRGGGRGQQRPTRKAGNSGSR-------------------------
MSMEG_1540|M.smegmatis_MC2_155 EGAAAARGGAHRGGRGRRPRRSNESSAR----------------------
TH_4173|M.thermoresistible__bu GDRYEGTRGHHHGDVHRRLRPQPHPTQRLHPVDVHRDADLPVGDRLGAGV
Mb3237|M.bovis_AF2122/97 -NTPRRRRTRGGKPVTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVV
Rv3211|M.tuberculosis_H37Rv -NTPRRRRTRGGKPVTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVV
MLBr_00811|M.leprae_Br4923 SNSVQRHRIRGGQPVTGHPTNNPSADSLA-----------TNGKVVAETL
Mflv_3959|M.gilvum_PYR-GCK --------------------------------------
Mvan_2437|M.vanbaalenii_PYR-1 --------------------------------------
MMAR_4824|M.marinum_M --------------------------------------
MUL_0393|M.ulcerans_Agy99 --------------------------------------
MAV_2956|M.avium_104 --------------------------------------
MAB_2158c|M.abscessus_ATCC_199 --------------------------------------
MSMEG_1540|M.smegmatis_MC2_155 --------------------------------------
TH_4173|M.thermoresistible__bu EPVLGQQAQLHDHHQRRRGAVVEPQQRGSDELLTIGNR
Mb3237|M.bovis_AF2122/97 SGSRSGNGEAARRRRRRRRRPTHAQDG-----FAARAN
Rv3211|M.tuberculosis_H37Rv SGSRSGNGEAARRRRRRRRRPTHAQDG-----FAARAN
MLBr_00811|M.leprae_Br4923 PNSSSGSPSTNVRRRRHRRKPTEVAENGLDKNLAVQAN