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VPTNEQRRATAKRKLERQLEHRAERERKRRQYTIIGSAVGGVLVVAAVVATIVLVNRDSGTETASASTST TETSSPFDVPPPAEAVTLPEFVAPEGLGGNCQYPEAEPASKPNNAPRTGKVPTEPAQVSASMETDQGNIG LQLDNGKSPCTVNSFASLAQQGYFANTPCHRLTTSDSLGVLQCGDPTGEGTGGPGYQFDNEYPTDQYQPD DPKLGEPVVYPRGTLAMANAGPGTNGSQFFLVYKDSQLPPQYTVFGTIDETGLETLDKIAEAGVDGGGPD GAPKLPVTVKNIQLD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3811 | - | - | 100% (295) | peptidyl-prolyl cis-trans isomerase, cyclophilin type |
| M. gilvum PYR-GCK | Mflv_0817 | - | 4e-16 | 33.16% (190) | peptidylprolyl isomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2613 | ppiB | 1e-106 | 64.86% (296) | peptidyl-prolyl cis-trans isomerase B |
| M. tuberculosis H37Rv | Rv2582 | ppiB | 1e-106 | 64.86% (296) | peptidyl-prolyl cis-trans isomerase B |
| M. leprae Br4923 | MLBr_00492 | ppiB | 1e-102 | 63.42% (298) | putative peptidyl-prolyl cis-trans isomerase |
| M. abscessus ATCC 19977 | MAB_2874 | - | 5e-96 | 59.55% (309) | peptidyl-prolyl cis-trans isomerase |
| M. marinum M | MMAR_2125 | ppiB | 1e-110 | 66.22% (296) | peptidyl-prolyl cis-trans isomerase B PpiB |
| M. avium 104 | MAV_3462 | - | 1e-106 | 65.44% (298) | peptidyl-prolyl cis-trans isomerase, cyclophilin-type |
| M. smegmatis MC2 155 | MSMEG_2974 | - | 1e-112 | 68.14% (295) | peptidyl-prolyl cis-trans isomerase, cyclophilin-type |
| M. thermoresistible (build 8) | TH_2333 | ppiB | 7e-94 | 60.14% (296) | PROBABLE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B PPIB |
| M. ulcerans Agy99 | MUL_1730 | ppiB | 1e-110 | 66.22% (296) | peptidyl-prolyl cis-trans isomerase B PpiB |
| M. vanbaalenii PYR-1 | Mvan_2588 | - | 1e-148 | 86.49% (296) | peptidyl-prolyl cis-trans isomerase, cyclophilin type |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3811|M.gilvum_PYR-GCK ------------------------------MPTNEQRRATAKRKLERQLE
Mvan_2588|M.vanbaalenii_PYR-1 --------MAAQRQLAHSVPTGSTARRTPAVPTNEQRRATAKRKLERQLE
MSMEG_2974|M.smegmatis_MC2_155 ------------------------------MPTNEQRRATAKRKLERQLE
Mb2613|M.bovis_AF2122/97 MGHLTPVAAPRLACA--------------FVPTNAQRRATAKRKLERQLE
Rv2582|M.tuberculosis_H37Rv MGHLTPVAAPRLACA--------------FVPTNAQRRATAKRKLERQLE
MMAR_2125|M.marinum_M ------------------------------MPTNQQRRATAKRKLERQLE
MUL_1730|M.ulcerans_Agy99 MGCLTRVSALTLAWAGHSARFTGQAGRTSAVPTNQQRRATAKRKLERQLE
MAV_3462|M.avium_104 ------------------------------MPTNEQRRANAKRKLERQLE
MLBr_00492|M.leprae_Br4923 ------------------------------MPTNEQRRATAKRKLKRQLE
MAB_2874|M.abscessus_ATCC_1997 ------------------------------MPTNEQRRQTAKRKLERQLE
TH_2333|M.thermoresistible__bu -----------------------------VPTTNAERREAAKRKLEEQLA
.** :** *****:.**
Mflv_3811|M.gilvum_PYR-GCK HRAERERKRRQYTIIGSAVGGVLVVAAVVATIVLVNRDSGTETASASTST
Mvan_2588|M.vanbaalenii_PYR-1 NRAERERKRRLYTIIGSAVAAVVVIAAVVATIVITNRDSGTQTASTATST
MSMEG_2974|M.smegmatis_MC2_155 RRAARARKQRILTIAGSVVA-VLVIGAVITTLVITDKDGGGDTTASAATS
Mb2613|M.bovis_AF2122/97 RRAKQAKRRRILTIVGGSLAAVAVIVAVVFTVVVNKDDHQSTTSATPTDS
Rv2582|M.tuberculosis_H37Rv RRAKQAKRRRILTIVGGSLAAVAVIVAVVVTVVVNKDDHQSTTSATPTDS
MMAR_2125|M.marinum_M RRAKQAKRRRILMIVGSAVAAVAVIAAVVVVVVINKGDHKTTASASPSSS
MUL_1730|M.ulcerans_Agy99 RRAKQAKRRRILMIVGSAVAAVAVIAAVVVVVVINKGDHKTTASASPSSS
MAV_3462|M.avium_104 RRAKQARTRRILLIAAGSIVAVAVIAAVVVTVLNNRHEHKASTAAPSTST
MLBr_00492|M.leprae_Br4923 RRAKQARWRRVLLISGGVVVAVAVIITVVATVVISKLGHKHDTASSTASN
MAB_2874|M.abscessus_ATCC_1997 NRAERARKQRIWAISGVAVLAVVVAVAITAWFAISKGDKTDTAHDTASTT
TH_2333|M.thermoresistible__bu RREARARRNRLLAVIGSVVAVIALVGAAVYVFVLDRDDAESDTTAQSETP
.* : : .* : . : : : : . : .
Mflv_3811|M.gilvum_PYR-GCK TETSSPFDVPPPAEAVT--------LPEFVAPEGLGGNCQYP-EAEPASK
Mvan_2588|M.vanbaalenii_PYR-1 TQTSSPFDVPPPTEAGA--------LPEFVAAEGLGSDCQYPKSAEAASK
MSMEG_2974|M.smegmatis_MC2_155 SEAAEP------AADGQ--------LPPFVAPADLGANCQYP-AAGEASK
Mb2613|M.bovis_AF2122/97 ASTS---PPQAATAPP---------LPPFKPSANLGANCQYPPSPDKAVK
Rv2582|M.tuberculosis_H37Rv ASTS---PPQAATAPP---------LPPFKPSANLGANCQYPPSPDKAVK
MMAR_2125|M.marinum_M EPTSSAAAPADDSVPP---------LPAFKPSANLGANCQYPASPDKAAK
MUL_1730|M.ulcerans_Agy99 EPTSSAAAPADDSVPP---------LPAFKPSANLGANCQYPASPDKAAK
MAV_3462|M.avium_104 SAPETTTPGQPSQVPP---------LPPFKPSADVGANCQYPPSPEPAAK
MLBr_00492|M.leprae_Br4923 SLTATKTPAVTPSVLP---------LPSFQPSTNLGVNCQYPPSADKAAK
MAB_2874|M.abscessus_ATCC_1997 PVSTVDAPPTSSLPTPDEPPLAGPALPKFVPSAEVGANCQYRPS-GKASK
TH_2333|M.thermoresistible__bu DTQLAGPTPLPAGGPGQ--------LPAFNPPPDLGADCQYPAAATPASK
** * .. :* :*** * *
Mflv_3811|M.gilvum_PYR-GCK PNN--APRTGKVPTEPAQVSASMETDQGNIGLQLDNGKSPCTVNSFASLA
Mvan_2588|M.vanbaalenii_PYR-1 SNN--PPRSGKVPTEPALVSASMATDQGNIGLQLDNGKSPCTVNSFASLA
MSMEG_2974|M.smegmatis_MC2_155 PVE--PPRSGKVPTDPATISVSMVTTQGNIGLQLDNAKAPCTVNSFASLA
Mb2613|M.bovis_AF2122/97 PVK--LPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPCTVNSFVSLA
Rv2582|M.tuberculosis_H37Rv PVK--LPRTGKVPTDPAQVSVSMVTNQGNIGLMLANNESPCTVNSFVSLA
MMAR_2125|M.marinum_M PAK--PPRSGKVPTEPAQVSASMMTSQGKVGLMLANNESPCTVNSFASLA
MUL_1730|M.ulcerans_Agy99 PAK--PPRSGKVPTEPAQVSASMMTSQGKVGLMLANNESPCTVNSFASLA
MAV_3462|M.avium_104 QVK--PPRTGKVPTDPAQVSASMVTNQGHIGLMLANNESPCTVNSFASLI
MLBr_00492|M.leprae_Br4923 PVK--PPRAGKVPTDPATVSASMATNQGNIGLLLNNAESPCTVNSFASLT
MAB_2874|M.abscessus_ATCC_1997 TIEKQIPRTGKIPTDPATLTASMKTSQGNIGLVLDNAKAPCTVNSFASLA
TH_2333|M.thermoresistible__bu EVN--PPRTGKVPTDPEWVSVSMSTNQGNLGLWLDNGKAPCTVNSFVSLA
: **:**:**:* ::.** * **::** * * ::*******.**
Mflv_3811|M.gilvum_PYR-GCK QQGYFANTPCHRLTTSDSLGVLQCGDPTGEGTGGPGYQFDNEYPTDQYQP
Mvan_2588|M.vanbaalenii_PYR-1 QQGFFNDTPCHRLTTSDSLGVLQCGDPTGEGTGGPGYEFANEYPTDQYQP
MSMEG_2974|M.smegmatis_MC2_155 AKDYFNDTPCHRLTTGG-LSVLQCGDPTGTGTGGPGYQFANEYPTNQYQP
Mb2613|M.bovis_AF2122/97 QQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSA
Rv2582|M.tuberculosis_H37Rv QQGFFKGTTCHRLTTSPMLAVLQCGDPKGDGTGGPGYQFANEYPTDQYSA
MMAR_2125|M.marinum_M QQGFFKDTKCHRLTTSPTLSVLQCGDPKGDGTGGPGYQFANEYPTDQYPP
MUL_1730|M.ulcerans_Agy99 QQGFFKDTKCHRLTTSPTLSVLQCGDPKGDGTGGPGYQFANEYPTDQYPP
MAV_3462|M.avium_104 GQKYFDNTKCHRLTTSPSLGVLQCGDPKGEGTGGPGYQFANEYPTDQYPP
MLBr_00492|M.leprae_Br4923 GQGFFNNTKCHRLTTSLMLGVLQCGDPKVDGTGGPGYKFANEYPTDQYPP
MAB_2874|M.abscessus_ATCC_1997 QGGYFDNTVCHRMTSG-GLSVLQCGDPTATGSGGPGYEFDNEYPTTQYKA
TH_2333|M.thermoresistible__bu QQGYFDDTTCHRLTATPALSVLQCGDPTGTGAGGPGYQFGNEYPTNQYPQ
:* .* ***:*: *.*******. *:*****:* ***** **
Mflv_3811|M.gilvum_PYR-GCK DDPKLGEPVVYPRGTLAMAN-AGPGTNGSQFFLVYKDSQLPPQYTVFGTI
Mvan_2588|M.vanbaalenii_PYR-1 DDPALGAPVVYPRGTLAMAN-AGPGTNGSQFFLVYKDSQLPPQYTVFGTI
MSMEG_2974|M.smegmatis_MC2_155 DNPALQQPVVYPRGTVAMAN-AGPGTNGSQFFLVYQDSQLPPNYTVFGKI
Mb2613|M.bovis_AF2122/97 NDPKLNEPVIYPRGTLAMAN-AGPNTNSSQFFMVYRDSKLPPQYTVFGTI
Rv2582|M.tuberculosis_H37Rv NDPKLNEPVIYPRGTLAMAN-AGPNTNSSQFFMVYRDSKLPPQYTVFGTI
MMAR_2125|M.marinum_M NDPALRQPVIYPRGTLAMAN-AGPDTNSSQFFMVYRDSQLPPQYTVFGTI
MUL_1730|M.ulcerans_Agy99 NDPALRQPVIYPRGTLAMAN-AGPDTNSSQFFMVYRDSQLPPQYTVFGTI
MAV_3462|M.avium_104 NDPKAQQPVLYPRGTLAMAN-ARPGTNGSQFFMVYKDSQLPPQYTVFGKI
MLBr_00492|M.leprae_Br4923 NDPKLKQPVLYPRGTLAMAN-SGPNTNGSQFFLVYHDSQLPPEYTVFGTI
MAB_2874|M.abscessus_ATCC_1997 DDPAAQQAVVYPAGTLAMAN-AGPGTNGSQFFMVYKDSKLPPQYTVFGTI
TH_2333|M.thermoresistible__bu GDPALQEPVTYPRGALAMAHSAGQHNNGSQFFLVYQDSQLPPDYTVFGVI
.:* .* ** *::***: : .*.****:**:**:***:***** *
Mflv_3811|M.gilvum_PYR-GCK DETGLETLDKIAEAGVDGGGP---DGAPKLPVTVKNIQLD
Mvan_2588|M.vanbaalenii_PYR-1 DETGLQTLDKIAAAGVAGGGP---DGAPQLATTVKSIQLD
MSMEG_2974|M.smegmatis_MC2_155 DETGLATLDKIAAGGVEGGGP---DGKPALDVELKSVALD
Mb2613|M.bovis_AF2122/97 QADGLTTLDKIAKAGVAGGGE---DGKPATEVTITSVLLD
Rv2582|M.tuberculosis_H37Rv QADGLTTLDKIAKAGVAGGGE---DGKPATEVTITSVLLD
MMAR_2125|M.marinum_M QADGLETLDKIAKAGVAGGGE---DGPPALDVTIKSVFLD
MUL_1730|M.ulcerans_Agy99 QADGLETLDKIAKAGVAGGGE---DGPPALDVTIKSVFLD
MAV_3462|M.avium_104 QDDGLATLDKIAKAGVAGGGE---DGAPATEVTITSVLLD
MLBr_00492|M.leprae_Br4923 QADGLATLDKIAKGGIASGGD---DGPPATEVTIESLRLD
MAB_2874|M.abscessus_ATCC_1997 DKTGMDTLAKIAKNGIKPGARGAGDGEPAQEVKIIDLQLD
TH_2333|M.thermoresistible__bu DETGLETLDKIAAAGIAGNAM---DGAPAEEVRVTSILMD
: *: ** *** *: .. ** * . : .: :*