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TDEWQSGRAEPLAVGPPRQRMTRRERARAERQRRRRRAGLVITLSMLVVVVVVAVFLGSKMWHSLFGGTT GDYAGDGVSDVVIQVHDGDSTTAIGQTLQDNNVVANVKTFVDAADGNSAISAIQPGFYKVRTEIPASSAV QRLADPANRVGKLTIPEGRQLDDVRDVKTNAVTAGILTLIANASCVDLDGDRRCVSADDLKQIAGAAAPA DLGVPQWATDAVDRMGADHRRLEGLIAPGTWNIDPSAQPQDILFTLISTSASQYEQSGLLTAAESVDLSP YEILTVASLVQREATPEDFSKVARVIYNRLDERRTLEFDSTVNYPLDRVEVATTDADRGQATPWNTYVRP GLPATPICSPGNPALVAAENPEPGDWLYFVTIDLQGTTLFTREYEQHLANIQLALRNGVLDSGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3761 | - | - | 100% (415) | aminodeoxychorismate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2583c | - | 1e-147 | 63.88% (418) | hypothetical protein Mb2583c |
| M. tuberculosis H37Rv | Rv2553c | - | 1e-147 | 63.88% (418) | hypothetical protein Rv2553c |
| M. leprae Br4923 | MLBr_00514 | - | 1e-145 | 63.35% (412) | hypothetical protein MLBr_00514 |
| M. abscessus ATCC 19977 | MAB_2849c | - | 1e-136 | 59.86% (416) | hypothetical protein MAB_2849c |
| M. marinum M | MMAR_2172 | - | 1e-148 | 63.72% (419) | hypothetical protein MMAR_2172 |
| M. avium 104 | MAV_3429 | - | 1e-148 | 63.44% (413) | hypothetical protein MAV_3429 |
| M. smegmatis MC2 155 | MSMEG_3027 | - | 1e-170 | 70.36% (415) | hypothetical protein MSMEG_3027 |
| M. thermoresistible (build 8) | TH_0112 | - | 1e-155 | 72.39% (373) | PROBABLE CONSERVED MEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_1756 | - | 1e-146 | 63.25% (419) | hypothetical protein MUL_1756 |
| M. vanbaalenii PYR-1 | Mvan_2642 | - | 0.0 | 82.89% (415) | aminodeoxychorismate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2583c|M.bovis_AF2122/97 ------------MPDG-GHRHRAQPVSVRPNRHRRTRVSRAQR-RHAQQI
Rv2553c|M.tuberculosis_H37Rv ------------MPDG-GHRHRAQPVSVRPNRHRRTRVSRAQR-RHAQQI
MMAR_2172|M.marinum_M ------------MAED-VYRSRAEPVAVGPNRHRMSRVDRLKRNREQHNR
MUL_1756|M.ulcerans_Agy99 ------------MAED-VYRSRAEPVAVGPNRHRMSRVDRLKRNREQHNR
MAV_3429|M.avium_104 ------------MVDS-ARRERAEPEAVGPPRRRSS---RMARNRAERG-
MLBr_00514|M.leprae_Br4923 ------------MGDSYLARHRLAPEAAGLGRHQMSSGDRDGR-RLAKSG
Mflv_3761|M.gilvum_PYR-GCK ------------MTDE-WQSGRAEPLAVGPPRQRMTRRERARA----ERQ
Mvan_2642|M.vanbaalenii_PYR-1 ------------MTDD-WQTDRAEPLAVGPPRRRLTRRERARE----ERY
MSMEG_3027|M.smegmatis_MC2_155 ------------MAED-WGAERARPVAVGPPRRGLSRAERARK----ARN
TH_0112|M.thermoresistible__bu --------------------------------------------------
MAB_2849c|M.abscessus_ATCC_199 MSDWRDWDDRQEHDDDWGGGRRAVPVAVGP-RPRETRRERARR----RAA
Mb2583c|M.bovis_AF2122/97 RRRRRVAGGFALSLLVVVVVVAVVVGAKLWQTMLGFGN---DYTGPGKRD
Rv2553c|M.tuberculosis_H37Rv RRRRRVAGGFALSLLVVVVVVAVVVGAKLWQTMLGFGN---DYTGPGKRD
MMAR_2172|M.marinum_M RRRRRVLGGFVFGLLVVFVVVVVVFGTKLWNVMLGTGG---DYAGPGKRD
MUL_1756|M.ulcerans_Agy99 RRRRRVLGGFVFGLLVVFVVVVVVFGTKLLNVMLGTGG---DYAGPGKRD
MAV_3429|M.avium_104 RRRRRFALRAALALLVVVVLAGVFAGGKLWHTVFGPGD---DYSGSGERD
MLBr_00514|M.leprae_Br4923 YRCRRFADKIVFGLLVVVVVLATFVGLRLWHTLFGSADGYTDYAGAGKHD
Mflv_3761|M.gilvum_PYR-GCK RRRRRAGLVITLSMLVVVVVVAVFLGSKMWHSLFGGTTG--DYAGDGVSD
Mvan_2642|M.vanbaalenii_PYR-1 RRRRKTALVVTLSMLVVVVLVAVFLGSKMWHSLFGGPGD--DFAGAGVND
MSMEG_3027|M.smegmatis_MC2_155 DRKRRLARALSLALLIVVAVGAVFLGSKLWHSMSG-STS--DYAGDGVAD
TH_0112|M.thermoresistible__bu ---------MSLSVLIVVMIGAVFLGSRLWHSMFG-TPT--DFRGDGVAD
MAB_2849c|M.abscessus_ATCC_199 ARRRRNAGILGLAAVVIITVAAVVGGATLWDSLFGADRPVTDYSGSGVKD
:. :::. : .. * : . : * *: * * *
Mb2583c|M.bovis_AF2122/97 IVIQIRAGDSTTAVGETLLKHGVVATVRAFVDAAHGNTAISSIQPGFYRM
Rv2553c|M.tuberculosis_H37Rv IVIQIRAGDSTTAVGETLLKHGVVATVRAFVDAAHGNTAISSIQPGFYRM
MMAR_2172|M.marinum_M VVIHISPGDSTTAVGETLYNNHVVATVRAFVDAAHGNAVIAAIQPGFYLV
MUL_1756|M.ulcerans_Agy99 VVIHISPGDSTTAVGETLYNNHVVATVRAFVDAAHGNAVIAAIQPGFYMV
MAV_3429|M.avium_104 LVIQIQAGDSTTMVGETLHNQHVVKTVRAFVNAAHGNSKIDSIQPGFYRM
MLBr_00514|M.leprae_Br4923 IMIQIHAGDSTTVIGETLRNQGVVASVRAFVDASHGNAAISSIQPGFYRM
Mflv_3761|M.gilvum_PYR-GCK VVIQVHDGDSTTAIGQTLQDNNVVANVKTFVDAADGNSAISAIQPGFYKV
Mvan_2642|M.vanbaalenii_PYR-1 VVIQVHDGDSTTAIGQTLHDNNVVANVKVFVEAADGNAAISAIQPGFYKV
MSMEG_3027|M.smegmatis_MC2_155 VVIQVHDGDSTTAIGETLVEKNVIATVKSFVEAAQGNDAISAIQPGFYKV
TH_0112|M.thermoresistible__bu VVIEVRDGDTTTAIGQTLQEHNVVATVKAFVDAAAGNAAISSIQPGFYKM
MAB_2849c|M.abscessus_ATCC_199 FVFEVHRGDTTKVIGQRLKDEGVVATPSAFTDAAAGNQAIAAIQPGFYKL
.::.: **:*. :*: * .. *: . *.:*: ** * :****** :
Mb2583c|M.bovis_AF2122/97 RTEISAASAVARLTDPHNRVGKLVIPEGRQLDDTTDMKTNVVNPGIFALI
Rv2553c|M.tuberculosis_H37Rv RTEISAASAVARLTDPHNRVGKLVIPEGRQLDDTTDMKTNVVNPGIFALI
MMAR_2172|M.marinum_M RTEIPAADAVARLADPKNRVGKLVIPEGRQLDDTTDMKTNVVTPGILTLI
MUL_1756|M.ulcerans_Agy99 RTEIPAADAVARLADPKNRVGKLVIPEGRQLDDTTDMKTNVVTPGILTLI
MAV_3429|M.avium_104 RTEIPASDAVARLADPNSRVGRLVIPEGRQLDDTTDMKTNKVNPGIFTLI
MLBr_00514|M.leprae_Br4923 RTEIPAAAAAARLADPENRVGKLVIPEGRQLDDATDMTTGKVNPGIFSLI
Mflv_3761|M.gilvum_PYR-GCK RTEIPASSAVQRLADPANRVGKLTIPEGRQLDDVRDVKTNAVTAGILTLI
Mvan_2642|M.vanbaalenii_PYR-1 RTEIPAADAVDRLADPGNRVGKLVIPEGRQLDDVRDVKTNAVTEGILTLI
MSMEG_3027|M.smegmatis_MC2_155 RTEIPAANAVERLSDPENRVGKLTIPEGRQLDDIADVKTNDVTAGILSLI
TH_0112|M.thermoresistible__bu RTEIPAADAVARLADPENRVGKLVIPEGRQLDDTRDVKTDRVTEGILTMI
MAB_2849c|M.abscessus_ATCC_199 RTKIAGKEAVARLAEQDNRVGLLVIPEGRQLDDVSAVSNGAVTEGIFTLI
**:*.. *. **:: .*** *.********* :... *. **:::*
Mb2583c|M.bovis_AF2122/97 SRATCVDLDGTQRCVSVADLRAAASRSTPTMLSVPRWAVGPVMELGTDHR
Rv2553c|M.tuberculosis_H37Rv SRATCVDLDGTQRCVSVADLRAAASRSTPTMLSVPRWAVGPVMELGTDHR
MMAR_2172|M.marinum_M SRATCVDLDGKKHCISMADLRTAATKSTPATLAVPSWAVEPVLELGADHR
MUL_1756|M.ulcerans_Agy99 SRATCVDLDGKKHCMSMADLRTAATKSTPATLAVPSWAVEPVLELGADHR
MAV_3429|M.avium_104 SQATCVDLDGNRRCVPVQQLRAAATNSTTAALSVPPWALEPVNELGRDHR
MLBr_00514|M.leprae_Br4923 SRATCVDLDGNRHCVSLNDLRAATRRTSLAKLSVPAWATESVIELGNDHR
Mflv_3761|M.gilvum_PYR-GCK ANASCVDLDGDRRCVSADDLKQIAGAAAPADLGVPQWATDAVDRMGADHR
Mvan_2642|M.vanbaalenii_PYR-1 SKASCVDLDGDRHCVSADDLRNTAAGADPAELGVPQWATEPVEALGSDLR
MSMEG_3027|M.smegmatis_MC2_155 SQASCVELDGEKRCVPVEDLRAAAGATPAAALAVPSWATQPVAAMGDDHR
TH_0112|M.thermoresistible__bu ARASCVDLDGEERCMSVEQLREVASTAPAAALSVPHWAEPAVRAMGDDPR
MAB_2849c|M.abscessus_ATCC_199 ARASCVDLDGDKHCVAASDLRQAATTASQGELDVPDWASNGVNAVRDDHR
:.*:**:*** .:*:. :*: : : * ** ** * : * *
Mb2583c|M.bovis_AF2122/97 RIEGLIAPGTFNIDPSASAETILATLISAGAVEYMKSGLVDTAKSLGLSP
Rv2553c|M.tuberculosis_H37Rv RIEGLIAPGTFNIDPSASAETILATLISAGAVEYMKSGLVDTAKSLGLSP
MMAR_2172|M.marinum_M RIEGLIAPGTFNIDPAGSADKILASLISAGAVEYLKSGLVDNAKSLGLSP
MUL_1756|M.ulcerans_Agy99 RIEGLIAPGTFNIDPAGSADKILASLISAGAVEYLKSGLVDNAKSLGLSP
MAV_3429|M.avium_104 RIEGLIAPGTFNVDPSASPESILAGLISAGAEEYLKSGLVDTAQAMGLSP
MLBr_00514|M.leprae_Br4923 RIEGLIAPGTFNVDPSASADSIMANLISTSAVGYTDSGLVDTARSLGLSP
Mflv_3761|M.gilvum_PYR-GCK RLEGLIAPGTWNIDPSAQPQDILFTLISTSASQYEQSGLLTAAESVDLSP
Mvan_2642|M.vanbaalenii_PYR-1 RLEGLIAPGSWNIDPSAQPQDILSTLISASATLYEQNGLLDAAAAVNMSP
MSMEG_3027|M.smegmatis_MC2_155 RLEGLIAPGTWNIDPDASAQDILSNLIAASSAVYTQSGLLDTAAAMKMSP
TH_0112|M.thermoresistible__bu RLEGLIAAGTWNINPAATPQQTLSTLISASAALYAQNGLLEAAERANMSP
MAB_2849c|M.abscessus_ATCC_199 RIEGLIAAGRWDFDPMAEPEQILASLIRESNAQYQQLGLLS-SDAAGLSP
*:*****.* ::.:* . .: : ** . * . **: : :**
Mb2583c|M.bovis_AF2122/97 YDILVVASLVQQEANTQDFPKVARVIYNRLHEHRTLEFDSTVNYPLDRRE
Rv2553c|M.tuberculosis_H37Rv YDILVVASLVQQEANTQDFPKVARVIYNRLHEHRTLEFDSTVNYPLDRRE
MMAR_2172|M.marinum_M YDILVVASLVQQESNAQDFPKVARVIYNRLNEHRALEFDSTVNYSLDRRE
MUL_1756|M.ulcerans_Agy99 YDILVVASLVQQESNAQDFPKVARVIYNRLNEHRALEFDSTVNYSLDRRE
MAV_3429|M.avium_104 YDILVVASLVQQESNTPDFAKVAQVIYNRLHAHHTLEFDSTVNYPLDRRE
MLBr_00514|M.leprae_Br4923 YAILVVASLVQQEASPQDFPKVARVIYNRLYEHRTLEFDSTVNYPLDRRE
Mflv_3761|M.gilvum_PYR-GCK YEILTVASLVQREATPEDFSKVARVIYNRLDERRTLEFDSTVNYPLDRVE
Mvan_2642|M.vanbaalenii_PYR-1 YQILTVASLVQREATPEDFSKVARVIYNRLAERRTLEFDSTVNYPLDRIE
MSMEG_3027|M.smegmatis_MC2_155 YEILTVASLVQRESKPQDFSKVSRVIYNRLAEHRKLEFDSTVNYSLDRQE
TH_0112|M.thermoresistible__bu YEILTVASLVQRESTPEDFAKVARVIYNRLAVNQKLEFDSTVNYALDRQE
MAB_2849c|M.abscessus_ATCC_199 YQVLVVASLLQREAKPRDFAKVARVVYNRLAKHQKLEFDSTVNYPLDRQE
* :*.****:*:*:.. **.**::*:**** .: *********.*** *
Mb2583c|M.bovis_AF2122/97 VATSDTDRAQRTPWNTYMAQGLPATAICSPGVDALRAAEHPVPGDWLYFV
Rv2553c|M.tuberculosis_H37Rv VATSDTDRAQRTPWNTYMAQGLPATAICSPGVDALRAAEHPVPGDWLYFV
MMAR_2172|M.marinum_M VATSDADRAMRTPWNTYMSEGLPATAICSPGVEALHAAEHPQPGDWLYFV
MUL_1756|M.ulcerans_Agy99 VATSDADRAMRTPWNTYMSEGLPATAICSPGVEALHAAEHPQPGDWLYFV
MAV_3429|M.avium_104 VATSDADRGQKTPWNTYVSQGLPATAICSPGIDALHAAEHPAPGDWLYFV
MLBr_00514|M.leprae_Br4923 VATSDADRGLWTPWNTYVSPGLPATAICSPGIDALYAAEHPEPGDWLYFV
Mflv_3761|M.gilvum_PYR-GCK VATTDADRGQATPWNTYVRPGLPATPICSPGNPALVAAENPEPGDWLYFV
Mvan_2642|M.vanbaalenii_PYR-1 VATTDGDRAQLTPWNTYVRPGLPATPICSPSQAALVAAENPEPGDWLYFV
MSMEG_3027|M.smegmatis_MC2_155 IATTDADRAQVTPWNTYASEGLPRTPICSPGIDALGSAEHPEPGDWLYFV
TH_0112|M.thermoresistible__bu VATTDEDRGQVTPWNTYMSEGLPATPICSPSKSALLAAEQPEPGDWLFFV
MAB_2849c|M.abscessus_ATCC_199 VATTDEDRERKTLWNTYVSQGLPGTPISSPSPEALQAAERPESGDWLYFV
:**:* ** * **** *** *.*.**. ** :**.* .****:**
Mb2583c|M.bovis_AF2122/97 TIDSQGTTLFTRDYQQHLANIELAKHNGVLDSAR-
Rv2553c|M.tuberculosis_H37Rv TIDSQGTTLFTRDYQQHLANIELAKHNGVLDSAR-
MMAR_2172|M.marinum_M TIDSQGTTLFTRDYQQHLANIELAKRNGVLDSAR-
MUL_1756|M.ulcerans_Agy99 TIDSQGTTRFTRDYQQHLANIELAKRNGVLDSAR-
MAV_3429|M.avium_104 TIDAAGTTLFTKDYQQHLANIELAKHNGVLDSTPR
MLBr_00514|M.leprae_Br4923 TVDTQGTTLFTRDYQQHLTNIELAKHNGVLDSVR-
Mflv_3761|M.gilvum_PYR-GCK TIDLQGTTLFTREYEQHLANIQLALRNGVLDSGR-
Mvan_2642|M.vanbaalenii_PYR-1 TVDMQGTTLFTREYEQHLANIEVAQRNGVLDSAR-
MSMEG_3027|M.smegmatis_MC2_155 TIDMQGTTLFTRDYDQHLANIEIAQRNGVLDSAR-
TH_0112|M.thermoresistible__bu TIDMEGTTLFTRDYEQHLINIQEALRNGVLDSAR-
MAB_2849c|M.abscessus_ATCC_199 TIDAEGTTLFTADYNEHLANIELAKKNGILDSAR-
*:* *** ** :*::** **: * :**:***