For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SILVVTGTGTGIGKTVVTAALACHARLAGLDVAVCKPIQTGTRDGDDDLAVVARLAGVEDLHSLAKFPEP LAPLAAAHRAGADLPSRAALDDLIAAVDRPGRLTLVEGAGGLLVEIGRGGVTLRDLAEDLRAPVLTVVAP GLGTLNHTVLTLEALAHRDVRSEGLVIGSWPAQPGVAEIDNRDALARLGPVRAALPAGAGTLSGTDFERL SVQAFDEAWVRGLVG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3627 | bioD | - | 100% (226) | dithiobiotin synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1597 | bioD | 3e-76 | 65.04% (226) | dithiobiotin synthetase |
| M. tuberculosis H37Rv | Rv1570 | bioD | 4e-76 | 65.04% (226) | dithiobiotin synthetase |
| M. leprae Br4923 | MLBr_01218 | bioD | 8e-76 | 62.67% (225) | dithiobiotin synthetase |
| M. abscessus ATCC 19977 | MAB_2686c | bioD | 9e-61 | 55.95% (227) | dithiobiotin synthetase |
| M. marinum M | MMAR_2385 | bioD | 1e-74 | 64.16% (226) | dethiobiotin synthetase BioD |
| M. avium 104 | MAV_3204 | bioD | 3e-78 | 65.49% (226) | dithiobiotin synthetase |
| M. smegmatis MC2 155 | MSMEG_3190 | bioD | 2e-78 | 66.96% (224) | dithiobiotin synthetase |
| M. thermoresistible (build 8) | TH_2514 | - | 8e-79 | 64.78% (230) | PUTATIVE dethiobiotin synthase |
| M. ulcerans Agy99 | MUL_1561 | bioD | 2e-75 | 64.16% (226) | dithiobiotin synthetase |
| M. vanbaalenii PYR-1 | Mvan_2790 | bioD | 1e-102 | 82.14% (224) | dithiobiotin synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3627|M.gilvum_PYR-GCK MSILVVTGTGTGIGKTVVTAALACHARLAGLDVAVCKPIQTGTRD-----
Mvan_2790|M.vanbaalenii_PYR-1 MSVLVVTGTGTGIGKTVATAALACHARLHGIDVAVCKPVQTGTRD-----
MSMEG_3190|M.smegmatis_MC2_155 MTVLAVTGTDTGVGKTVTTAALACAARLARRDVAVCKPVQTGTID-----
TH_2514|M.thermoresistible__bu MTVLLITGTGTGVGKTMTTAALACHARLAGIDVAVCKPVQTGSAGPDGGP
Mb1597|M.bovis_AF2122/97 MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTAR-----
Rv1570|M.tuberculosis_H37Rv MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTAR-----
MLBr_01218|M.leprae_Br4923 MTVVVVTGTDTGVGKTVACAALACHARQAGIEVAVCKPVQTGTQI-----
MMAR_2385|M.marinum_M MTVLCVTGTCTGVGKTVVTAALASQANQAGIDVVVCKPVQTGTGI-----
MUL_1561|M.ulcerans_Agy99 MTVLCVTGTCTGVGKTVVTAALASQANQAGIDVVVCKPVQTGTGN-----
MAV_3204|M.avium_104 MTVLVVTGTDTGVGKTVATAALACHARRAGIDVAVCKPVQTGTDD-----
MAB_2686c|M.abscessus_ATCC_199 MTILLVTGTSTGVGKTVATAALAAAAVRQGIDVTVCKPVQTGDDH-----
*::: :*** **:***:. ****. * :*.****:***
Mflv_3627|M.gilvum_PYR-GCK GDDDLAVVARLAGVEDLHSLAKFPEPLAPLAAAHRAGADLPSRAALDDLI
Mvan_2790|M.vanbaalenii_PYR-1 GDDDLAEVARLAGVTELHSLARFPEPLAPLAAARRSGAELPTRAQILDLI
MSMEG_3190|M.smegmatis_MC2_155 GDDDLGEVRRLSGVTALHGGWRYPEPLAPVAAAGRAGAPLPTRTELVGSV
TH_2514|M.thermoresistible__bu GDDDLAEIGRLAGVTARYGRWRYPEPLAPPAAAERAGARLPTRSELVGFI
Mb1597|M.bovis_AF2122/97 GDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLI
Rv1570|M.tuberculosis_H37Rv GDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLI
MLBr_01218|M.leprae_Br4923 GDDDLAEVARLSGVTELTGLVRYPQPLAPAAAAEHAGMALPTREQLLELI
MMAR_2385|M.marinum_M GDDDLAEIGRLSGVTELVGLARYPLPMAPVAAAEQAGQPLPSRDQLVQHI
MUL_1561|M.ulcerans_Agy99 GDDDLAEIGRLSGVTELVGLARYPLPMAPVAAAEQAGQPLPSRDQLVQHI
MAV_3204|M.avium_104 GDDDLAEVARLSGVTELAGLARYPRPLAPVAAAAAAGMALPSREQLLRFI
MAB_2686c|M.abscessus_ATCC_199 ---DAGEVARLSGVTRVQTLVRYPEPLAPVASASRAGLELLDHTQMATAI
* . : **:** ::* *:** *:* :* * : : :
Mflv_3627|M.gilvum_PYR-GCK AAVDRPGRLTLVEGAGGLLVEIGRGGVTLRDLAEDLRAPVLTVVAPGLGT
Mvan_2790|M.vanbaalenii_PYR-1 TAADRPGRLTLVEGAGGLLVEIASDGSTLRDVAADLGAPVLTVVAPGLGT
MSMEG_3190|M.smegmatis_MC2_155 RAVDAAGRLTIVEGAGGLLVALGADGVTLRDLAHDLGAQVLIVVSPGLGT
TH_2514|M.thermoresistible__bu AEVAAAHRLTLVEGAGGLLVELAADGTTLRDVAVDLSAPVLVVVDAGLGT
Mb1597|M.bovis_AF2122/97 ADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGT
Rv1570|M.tuberculosis_H37Rv ADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGT
MLBr_01218|M.leprae_Br4923 AGLDRPGRLILVEGAGGLLVELADASATLRDLAVELGALALVTVSVELGT
MMAR_2385|M.marinum_M RGLDRPGRLTLVEGAGGLLVELADSGGTLRDLAVDLGAAMLVVVAAGLGT
MUL_1561|M.ulcerans_Agy99 RGLDRPGRLTLVEGAGGLLVELADSGGTLRDLAVDLGAAMLVVVAAGLGT
MAV_3204|M.avium_104 GELDRPGRLTLVEGAGGLLVELGENGVTARDLAVALGAAVLVVVRPALGT
MAB_2686c|M.abscessus_ATCC_199 VALDRPGALTLVEGAGGLLVELAADGKTLRDLAMVLDAPVLVVTTADLGT
. * :********* :. . * **:* : * * .. ***
Mflv_3627|M.gilvum_PYR-GCK LNHTVLTLEALAHRDVRSEGLVIGSWPAQPGVAEIDNRDALARLG--PVR
Mvan_2790|M.vanbaalenii_PYR-1 LNHTVLTLEALAHRQISSAGLVIGAWPAQPGVAEIDNRDALSRLA--PVR
MSMEG_3190|M.smegmatis_MC2_155 LNHTALTLEALAAHGLSCAGLVIGAWPAEPGVAELDNRTALEALA--PVR
TH_2514|M.thermoresistible__bu LNHTALTLESLARHEVRCEGLAIGAWPAQPGPAELSNREALARMA--TVR
Mb1597|M.bovis_AF2122/97 LNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIA--TVR
Rv1570|M.tuberculosis_H37Rv LNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIA--MVR
MLBr_01218|M.leprae_Br4923 LNHTALTLEALTTRGVACAGLVIGSWTGRPGAVQISNRSALARLA--PMR
MMAR_2385|M.marinum_M LNHTALTLEALAAQKVSCAGLVLGSWPAHPGLVESSNRDALARLA--PMR
MUL_1561|M.ulcerans_Agy99 LNHTALTLEALAAQKVSCAGLVLGSWPAHPGLVESSNRDALARLA--PMR
MAV_3204|M.avium_104 LNHTALTLEALAAQGLSCAGLVIGAWPEHPGPVETSNRPALEALA--PVR
MAB_2686c|M.abscessus_ATCC_199 LNHTALTLEALAVQSVPCAGLVVGSFPAEPDLAQRLNRENLANQFGTPVR
**** ****:*: : : . **.:*::. *. . ** * :*
Mflv_3627|M.gilvum_PYR-GCK AALPAGAGTLSGTDFERLSVQAFDEAWVRGLVG
Mvan_2790|M.vanbaalenii_PYR-1 AALPAGAGSLGRADFERLSVDAFDPSWVEGLAA
MSMEG_3190|M.smegmatis_MC2_155 AVLPAGAGAASPERFEALSAAAFDADWITSLS-
TH_2514|M.thermoresistible__bu AALPAGIGTLGDRDFERLAATSFAPGWVTGLV-
Mb1597|M.bovis_AF2122/97 AALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
Rv1570|M.tuberculosis_H37Rv AALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
MLBr_01218|M.leprae_Br4923 ATLPAGAGSMDATDFAAMSAAAFDRDWVTTLVH
MMAR_2385|M.marinum_M AVLSAGAAQLSVADFAVMSAGAFDREWVATLVG
MUL_1561|M.ulcerans_Agy99 AVLSAGAAQLSVADFAVMSAGAFDREWVATLVG
MAV_3204|M.avium_104 AVLPAGAAALAAAEFEAVSAGAFDRDWVTALAG
MAB_2686c|M.abscessus_ATCC_199 AVIPEGAARLMPPVFAELSIELFEPQWVAGLVA
*.:. * . * :: * *: *