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MSSATPPVTVAVTGAAGQIGYAALFRIAAGAMLGHDTPVTLRLLELPDAVRAAEGVVMELDDGAFPLLAG TEIYDDPTRAFDGVDVALLIGAKPRTKGMERADLLSANAQIFATSGRALNAGAGRDVRILVVGNPANTNA LVAAAHAPDIPRDRFTALTRLDHNRAVAAMARHSGVPVTEISRMIIWGNHSPTQYPDIFHSVVGGRAGAD YAADTRWLTDDFIPTVARRGTAIIEARGASSAASAANGAIDHVDDWMHGTPDGDWTSVALPSPGVYGVDE GLVCSFPCRSVDGRWEIVDGLDVNPFSRARIDASVAELRAERDAVAALGLL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3339 | - | - | 100% (331) | malate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4936 | - | 6e-05 | 26.37% (201) | carbohydrate kinase, YjeF related protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1272 | mdh | 1e-114 | 61.54% (325) | malate dehydrogenase |
| M. tuberculosis H37Rv | Rv1240 | mdh | 1e-114 | 61.54% (325) | malate dehydrogenase |
| M. leprae Br4923 | MLBr_01091 | mdh | 1e-115 | 61.85% (325) | malate dehydrogenase |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4198 | mdh | 1e-111 | 59.69% (325) | malate dehydrogenase Mdh |
| M. avium 104 | MAV_1380 | - | 1e-115 | 60.92% (325) | malate dehydrogenase |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_4504 | mdh | 1e-111 | 59.38% (325) | malate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3067 | - | 1e-177 | 92.17% (332) | malate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1272|M.bovis_AF2122/97 MS---ASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPA
Rv1240|M.tuberculosis_H37Rv MS---ASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPA
MMAR_4198|M.marinum_M MS---ASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPA
MUL_4504|M.ulcerans_Agy99 MS---ASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPA
MAV_1380|M.avium_104 MS---ASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPA
MLBr_01091|M.leprae_Br4923 MS---PRPLKVAVTGAAGQIGYSLLFRLASGSLLGLDRPIELRLLEIEPA
Mflv_3339|M.gilvum_PYR-GCK MSSATP-PVTVAVTGAAGQIGYAALFRIAAGAMLGHDTPVTLRLLELPDA
Mvan_3067|M.vanbaalenii_PYR-1 MSSTTASPVTVAVTGAAGHIGYAALFRIAAGAMLGHTTPVTLRLLELPDA
** . *:.********:***: ***:*:*::** *: *****: *
Mb1272|M.bovis_AF2122/97 LQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGM
Rv1240|M.tuberculosis_H37Rv LQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGM
MMAR_4198|M.marinum_M LKALEGVVMELDDCAFPLLSGVEIGSDANKIFDGANLALLVGARPRGPGM
MUL_4504|M.ulcerans_Agy99 LKALEGVVMELDDCAFPLLSGVEIGSDANKIFDGANLALLVGARPRGPGM
MAV_1380|M.avium_104 LKALEGVVMELDDCAFPLLSGVEIGADPNKIFDGANLALLVGARPRGPGM
MLBr_01091|M.leprae_Br4923 LKALEGVVMELDDCAFLLLAGVEIGADPNKVFDGVNLALLVGARPRGPGM
Mflv_3339|M.gilvum_PYR-GCK VRAAEGVVMELDDGAFPLLAGTEIYDDPTRAFDGVDVALLIGAKPRTKGM
Mvan_3067|M.vanbaalenii_PYR-1 VRAAEGVVMELEDGAFPLLAGTEIYDDPTRAFDGVDVALLIGARPRTKGM
::* *******:* ** **:*.** *. : ***..:***:**:** **
Mb1272|M.bovis_AF2122/97 ERSDLLEANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPD
Rv1240|M.tuberculosis_H37Rv ERSDLLEANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPD
MMAR_4198|M.marinum_M ERSDLLEANGAIFTAQGKALNEVAADDIRVGVTGNPANTNALIAMTNAPD
MUL_4504|M.ulcerans_Agy99 ERSDLLEANGAIFTAQGKALNEVAADDIRVGVTGNPANTNALIAMTNAPD
MAV_1380|M.avium_104 ERSDLLEANGAIFTAQGKALNEVAADDIRVGVTGNPANTNALIAMSNAPD
MLBr_01091|M.leprae_Br4923 ERGDLLEANGAIFTAQGKALNAVAAADIRVGVTGNPANTNALIAMTNAPD
Mflv_3339|M.gilvum_PYR-GCK ERADLLSANAQIFATSGRALNAGAGRDVRILVVGNPANTNALVAAAHAPD
Mvan_3067|M.vanbaalenii_PYR-1 ERADLLGANAEIFATSGKALNAGASPDVRVLVVGNPANTNALVASAHAPD
**.*** **. **::.*:*** *. *:*: *.*********:* ::***
Mb1272|M.bovis_AF2122/97 IPRERFSALTRLDHNRAISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLF
Rv1240|M.tuberculosis_H37Rv IPRERFSALTRLDHNRAISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLF
MMAR_4198|M.marinum_M IPRERFSALTRLDHNRAISQLAAKTGVAVTDIKKMTIWGNHSATQYPDLF
MUL_4504|M.ulcerans_Agy99 IPRERFSALTRLDHNRAISQLAAKTGVAVTDIKKMTIWGNHSATQYPDLF
MAV_1380|M.avium_104 IPRERFSALTRLDHNRAISQLAKKTGAKVTDITKMTIWGNHSATQYPDIF
MLBr_01091|M.leprae_Br4923 IPRERFSALTRLDHNRAIAQLATKTGSAVTDIRKMTIWGNHSATQYPDVF
Mflv_3339|M.gilvum_PYR-GCK IPRDRFTALTRLDHNRAVAAMARHSGVPVTEISRMIIWGNHSPTQYPDIF
Mvan_3067|M.vanbaalenii_PYR-1 IPADRFTALTRLDHNRAVAATARHSGVPVTEISRMTIWGNHSPTQYPDIF
** :**:**********:: * ::* **:* :* ******.*****:*
Mb1272|M.bovis_AF2122/97 HAEVAGKNAAEVVNDQAWIEDEFIPTVAKRGAAIIDARGASSAASAASAT
Rv1240|M.tuberculosis_H37Rv HAEVAGKNAAEVVNDQAWIEDEFIPTVAKRGAAIIDARGASSAASAASAT
MMAR_4198|M.marinum_M HAEVKGKNAAEVVNDQAWIEEYFIPTVAKRGAAIIDARGASSAASAASAT
MUL_4504|M.ulcerans_Agy99 HAEVKGKNAAEVVNDQAWIEEYFIPTVAKRGATIIDARGASSAASAASAS
MAV_1380|M.avium_104 HAEVKGKNAAEVVGDQNWIENDFIPTVAKRGAAIIDARGASSAASAASAT
MLBr_01091|M.leprae_Br4923 HAEIGGKNAAEVVGDQAWIEDYFIPTVAKRGAAIIDARGASSAASAASAT
Mflv_3339|M.gilvum_PYR-GCK HSVVGGRAGADYAADTRWLTDDFIPTVARRGTAIIEARGASSAASAANGA
Mvan_3067|M.vanbaalenii_PYR-1 HAVVGGRSGADYAADTRWLTDDFIPTVARRGTAIIEARGASSAASAANGA
*: : *: .*: . * *: : ******:**::**:***********..:
Mb1272|M.bovis_AF2122/97 IDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLISSFPVTTKGGNWTIVS
Rv1240|M.tuberculosis_H37Rv IDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLISSFPVTTKGGNWTIVS
MMAR_4198|M.marinum_M VDAARSWLLGTPADDWVSMAVLSDGSYGVPEGLISSFPVTTKDGNWSIVK
MUL_4504|M.ulcerans_Agy99 VDAARSWLLGTPADDWVSMAVLSDGSYGVPEGLISSFPVTTKDGNWSIVK
MAV_1380|M.avium_104 TDAARDWLLGTPAGDWVSMAVISDGSYGVPEGLISSFPVTTKDGDWTIVQ
MLBr_01091|M.leprae_Br4923 IDAARDWLLGTPEGNWVSMAVVSDGSYGVPEGLISSFPVTTTDGDWTIVR
Mflv_3339|M.gilvum_PYR-GCK IDHVDDWMHGTPDGDWTSVALPSPGVYGVDEGLVCSFPCRSVDGRWEIVD
Mvan_3067|M.vanbaalenii_PYR-1 IDHIDDWVHGTPDGDWTSVALPSPGAYGVDEGLVCSFPCRSVGGRWEIVE
* .*: *** .:*.*:*: * * *** ***:.*** : .* * **
Mb1272|M.bovis_AF2122/97 GLEIDEFSRGRIDKSTAELADERSAVTELGLI
Rv1240|M.tuberculosis_H37Rv GLEIDEFSRGRIDKSTAELADERSAVTELGLI
MMAR_4198|M.marinum_M GLEIDEFSRGRIDKTTAELADERKAVTELGLI
MUL_4504|M.ulcerans_Agy99 GLEIDEFSRGRIDKTAAELADERKAVTELGLI
MAV_1380|M.avium_104 GLEIDEFSRSRIDKTTAELADERNAVTQLGLI
MLBr_01091|M.leprae_Br4923 GLGIDDFSRGRIDKSTAELADERMAVKQLGLI
Mflv_3339|M.gilvum_PYR-GCK GLDVNPFSRARIDASVAELRAERDAVAALGLL
Mvan_3067|M.vanbaalenii_PYR-1 GLDINPFSRARIDASVAELRTERDAVAALGLL
** :: ***.*** :.*** ** ** ***: