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MFARASGIAAAVVADLVFGDPRRGHPVALFGSAAAGLERRTYADARGAGVVHTAALLTAVGAAGVLAERT GRRRGAVAEAASVAAATFVAAGGTTLCRTGEQMAGLLRGGDLDGARALLPSLCGRDPSALYAPGLARAAL ESIAENTSDAQIGPLVWAAAGGTPAVLVYRAANTLDAMIGSRSSRYARFGWAAARFDDLLNLVPARLTGL LVVACAPVVGGSPAAAWRAWRRDAGDHPSPNAGVVEASFAGALGVRLGGPTQYAHELEIRPTLGDGRAPD VDDLVRAVRLSRAVQGLAAALAVSAACRSGRRASARWSGPLRPRRSRLRRRPELSPGVAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2886 | cobD | - | 100% (340) | cobalamin biosynthesis protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2260c | cobD | 1e-104 | 64.59% (305) | cobalamin biosynthesis protein |
| M. tuberculosis H37Rv | Rv2236c | cobD | 1e-104 | 64.59% (305) | cobalamin biosynthesis protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1898 | - | 9e-95 | 59.09% (308) | cobalamin biosynthesis protein CobD |
| M. marinum M | MMAR_3311 | cobD | 1e-105 | 66.33% (297) | cobalamin biosynthesis transmembrane protein CobD |
| M. avium 104 | MAV_2205 | cobD | 1e-106 | 64.71% (306) | cobalamin biosynthesis protein |
| M. smegmatis MC2 155 | MSMEG_4310 | cobD | 1e-122 | 70.44% (318) | cobalamin biosynthesis protein |
| M. thermoresistible (build 8) | TH_1461 | cobD | 1e-90 | 75.80% (219) | Probable cobalamin biosynthesis transmembrane protein CobD |
| M. ulcerans Agy99 | MUL_1317 | cobD | 1e-105 | 66.55% (296) | cobalamin biosynthesis protein |
| M. vanbaalenii PYR-1 | Mvan_3624 | cobD | 1e-143 | 80.44% (317) | cobalamin biosynthesis protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2260c|M.bovis_AF2122/97 MFASIWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQITYRDG
Rv2236c|M.tuberculosis_H37Rv MFASTWQTRAVGVLIGCLLDVVFGDPKRGHPVALFGRAAAKLEQITYRDG
MMAR_3311|M.marinum_M MVASARQARTVGVLVGYLADLVLGDPQRGHPVAVFGRLAAGLERASYRDT
MUL_1317|M.ulcerans_Agy99 MVASARQARTVGVLVGYLADLVLGDPQRGHPVAVFGRLAAGLERASYRDT
MAV_2205|M.avium_104 MLA----THPVGVLIGYLADRALGDPRRGHPVALFGRAAAGLENLSYRDG
Mflv_2886|M.gilvum_PYR-GCK -----MFARASGIAAAVVADLVFGDPRRGHPVALFGSAAAGLERRTYADA
Mvan_3624|M.vanbaalenii_PYR-1 -----MFARGIGMAAGVAADLAFGDPRRGHPVALFGGAAAALERYTYADD
MSMEG_4310|M.smegmatis_MC2_155 ----MVAGAAAGIACGYLADLVFADPRRGHPVALFGSGAARLERLTYRDN
TH_1461|M.thermoresistible__bu --------------------------------------------------
MAB_1898|M.abscessus_ATCC_1997 --MSRRGLRAVGIALGYALDRCFADPQRFHPVAGFGQAAAALEAYSYRDS
Mb2260c|M.bovis_AF2122/97 RVAGAVHVGLLVGAVGLLGAALQRLPGRC---WPVAATATATWAALGGTS
Rv2236c|M.tuberculosis_H37Rv RVAGAVHVGLLVGAVGLLGAALQRLPGRS---WPVAATATATWAALGGTS
MMAR_3311|M.marinum_M RAAGAVHVGVLVGGVGLLGAVLGRPAGRP---WSVAATAMATWVSLGGTS
MUL_1317|M.ulcerans_Agy99 RAAGAVHVGVLVGGVGLLGAVLGRPAGRP---WSVAATAMATWVSLGGTS
MAV_2205|M.avium_104 RVAGALHVAVSIGAVGLLGLAVHRAAARAGPRWSIAATAAAGWVCSGGSS
Mflv_2886|M.gilvum_PYR-GCK RGAGVVHTAALLTAVGAAGVLAERTGRRRGAVAEAASVAAATFVAAGGTT
Mvan_3624|M.vanbaalenii_PYR-1 RRAGALHTAALLTGVGVAAAVVQQAGRRRGVPAEAACVAAATFIAAGGTT
MSMEG_4310|M.smegmatis_MC2_155 RAAGLAHTGLLLAGLALLGVAAQRRNRPH------LGLAAATFVALGGTS
TH_1461|M.thermoresistible__bu --------------------------------------------------
MAB_1898|M.abscessus_ATCC_1997 KLAGTAHTAALLVAVAATGWVAERATHRS-ATATVAVTAVATWATLGGTS
Mb2260c|M.bovis_AF2122/97 LARTGRQISDLLERDDVEAARRLLPSLCGRDPAQLGGPGLTRAALESVAE
Rv2236c|M.tuberculosis_H37Rv LARTGRQISDLLERDDVEAARRLLPSLCGRDPAQLGGPGLTRAALESVAE
MMAR_3311|M.marinum_M LVRTGREMAELLDRGDLDAARRLLPSLCGRDPAQLDVPDLTRAALESVAE
MUL_1317|M.ulcerans_Agy99 LVRTGREMAELLDRGDLDAARRLLPSLCGRDPAQLDVPDLTRAALESVAE
MAV_2205|M.avium_104 LTRTGLAMAELLQRGDVDAARRLLPSLCGRDPAALDAAGLARAALESVAE
Mflv_2886|M.gilvum_PYR-GCK LCRTGEQMAGLLRGGDLDGARALLPSLCGRDPSALYAPGLARAALESIAE
Mvan_3624|M.vanbaalenii_PYR-1 LSRTGEQMVRLLRASDVEGARRLLPSLCGRDPSVLDAAGLTRAALESIAE
MSMEG_4310|M.smegmatis_MC2_155 LNRVGDRMADLLAADDVDGARALVPSLCGRDPASLDAAGLTRATVESLAE
TH_1461|M.thermoresistible__bu -------MAALLRDGDIDGARALLPALCGRDPDALDPAGLTRAAVESVAE
MAB_1898|M.abscessus_ATCC_1997 LIRVGAEMSERLYDDDIDEARALLPSLCGRDPKLLGVGGIARATTESLAE
: * .*:: ** *:*:****** * .::**: **:**
Mb2260c|M.bovis_AF2122/97 NTADAQVVPLLWAASSGVPAVLGYRAINTLDSMIGYRSPRYLRFGWAAAR
Rv2236c|M.tuberculosis_H37Rv NTADAQVVPLLWAASSGVPAVLGYRAINTLDSMIGYRSPRYLRFGWAAAR
MMAR_3311|M.marinum_M NTSDAQVAPLLWAAVGGVPAVLVYRAVNTLDAMVGYRSPRYLRFGWAAAR
MUL_1317|M.ulcerans_Agy99 NTSDAQVAPLLWAAVGGVPAVLVYRAVNTLDAMIGYRSPRYLRFGWAAAR
MAV_2205|M.avium_104 NTSDAQVAPLLWAAAGGVPAVLAYRGINTLDAMIGHRSPRYLRFGWAAAK
Mflv_2886|M.gilvum_PYR-GCK NTSDAQIGPLVWAAAGGTPAVLVYRAANTLDAMIGSRSSRYARFGWAAAR
Mvan_3624|M.vanbaalenii_PYR-1 NTSDAQIGPLVWAAVGGAPAVLVYRAANTLDAMIGNRSPRYARFGWAAAR
MSMEG_4310|M.smegmatis_MC2_155 NTSDAQVAPLLWAAVAGVPGVLVYRGANTLDAMIGHRSPRYLRFGWAAAR
TH_1461|M.thermoresistible__bu NTSDAQVAPLLWAAVGGVPAVLVYRGANTLDAMIGHRSPRYARFGWAAAR
MAB_1898|M.abscessus_ATCC_1997 NTSDAHTGPLVWAALAGVPGVLAYRAANTLDAMIGHKSARYLRFGWAAAR
**:**: **:*** .*.*.** **. ****:*:* :*.** *******:
Mb2260c|M.bovis_AF2122/97 LDDWANYVGARATAVLVVICAPVVGGSPRGAVRAWRRDAARHPSPNAGVV
Rv2236c|M.tuberculosis_H37Rv LDDWANYVGARATAVLVVICAPVVGGSPRGAVRAWRRDAARHPSPNAGVV
MMAR_3311|M.marinum_M LDDLANYFGARVTAGLVVLCAPLVGGSALGAMRAWRRDAARHPSPNAGVV
MUL_1317|M.ulcerans_Agy99 LDDLANYFGARVTAGLVVLCAPLVGGSALGAVRAWRRDAARHPSPNAGVV
MAV_2205|M.avium_104 LDDIANYPAARVTASLTVLLAPVVGGSPSGAARAWRRDAARHPSPNAGVV
Mflv_2886|M.gilvum_PYR-GCK FDDLLNLVPARLTGLLVVACAPVVGGSPAAAWRAWRRDAGDHPSPNAGVV
Mvan_3624|M.vanbaalenii_PYR-1 FDDLLNLAPARLTGVLAVVCAPVVGGSPAEAWRVWQRDARKHPSPNAGVA
MSMEG_4310|M.smegmatis_MC2_155 FDDVLNYVPARVTGLLVAVCAPVVGGSPVAALRAWRRDAARHPSPNAGVV
TH_1461|M.thermoresistible__bu FDDLMNLVAARVTAALTVVCAPLVGGSAAASWRAWHRDARRHPSPNAGVV
MAB_1898|M.abscessus_ATCC_1997 LDDLMNVLPARITALATALTAPFLGGSAVASLRVCLRDGRSHPSPNAGVA
:** * ** *. .. **.:***. : *. **. ********.
Mb2260c|M.bovis_AF2122/97 EAAFAGALDVRLGGPTRYHHELQIRPTLGDGRSPKVADLRRAVVLSRVVQ
Rv2236c|M.tuberculosis_H37Rv EAAFAGALDVRLGGPTRYHHELQIRPTLGDGRSPKVADLRRAVVLSRVVQ
MMAR_3311|M.marinum_M EATFAGALRVRLGGPTRYHFELQIRPTLGDGGQPTVDDLRRAVTLSRAVQ
MUL_1317|M.ulcerans_Agy99 EAAFAGALRVRLGGPTRYHFELQIRPTLGDGGQPTVDDLRRAVTLSRAVQ
MAV_2205|M.avium_104 EAAFAGALGVRLGGPTQYRHQLQIRPTLGAGREPTVTDLRRAVRLSAAVQ
Mflv_2886|M.gilvum_PYR-GCK EASFAGALGVRLGGPTQYAHELEIRPTLGDGRAPDVDDLVRAVRLSRAVQ
Mvan_3624|M.vanbaalenii_PYR-1 EASFAGALGVRLGGPTQYAYELEIRPTLGDGRTPDVDDLARAVRLSRAVQ
MSMEG_4310|M.smegmatis_MC2_155 EASFAGALGVRLGGPTQYAHQLEIRPSLGDGRAPEVEDVGRAVRLSRAVQ
TH_1461|M.thermoresistible__bu EAAFAGALGIRLGGPTRYTHRLEIRPTLGDGPAPDVADLSRAVRLSRAVQ
MAB_1898|M.abscessus_ATCC_1997 EAAFAGALGVRLGGPLRYPYGEEVRPVLGDGAPPRVGDMHEAVRLSRAVQ
**:***** :***** :* . ::** ** * * * *: .** ** .**
Mb2260c|M.bovis_AF2122/97 AGAAVLAV--MLVYR------RRP--------------------------
Rv2236c|M.tuberculosis_H37Rv AGAAVLAV--MLVYR------RRP--------------------------
MMAR_3311|M.marinum_M AAAAVGAG--LFVYR------RRP--------------------------
MUL_1317|M.ulcerans_Agy99 AAAGVGAG--LFVYR------RRP--------------------------
MAV_2205|M.avium_104 AAAVALAAGLLAAYR------RRP--------------------------
Mflv_2886|M.gilvum_PYR-GCK GLAAALAVSAA------CRSGRRASARWSGPLRPRRSRLRRRPELSPGVA
Mvan_3624|M.vanbaalenii_PYR-1 LLAAVVAISVA------CRSGRRVSARY----------------------
MSMEG_4310|M.smegmatis_MC2_155 GAAALVAVAAAGWLSGACRSGRRASPRV----------------------
TH_1461|M.thermoresistible__bu TAAAGLAVGLAGMLS-AARSGRRVSPRR----------------------
MAB_1898|M.abscessus_ATCC_1997 NVTAVVAVLATLRQ-------RRP--------------------------
: * **
Mb2260c|M.bovis_AF2122/97 -
Rv2236c|M.tuberculosis_H37Rv -
MMAR_3311|M.marinum_M -
MUL_1317|M.ulcerans_Agy99 -
MAV_2205|M.avium_104 -
Mflv_2886|M.gilvum_PYR-GCK P
Mvan_3624|M.vanbaalenii_PYR-1 -
MSMEG_4310|M.smegmatis_MC2_155 -
TH_1461|M.thermoresistible__bu -
MAB_1898|M.abscessus_ATCC_1997 -