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VTRYDSLLQALGDTPLVGLQRLSPRWNDGEHGEPHVRLWAKLEDRNPTGSIKDRPALRMIEDAEREGRLH PGATILEPTSGNTGISLAMAALLKGYQMVCVMPENTSIERRQLLELYGARIIYSPAEGGSNTAVAHAKEL ALQNPSWVMLYQYGNPSNALAHYEGTGPELLADLPEITHFVAGLGTTGTLMGTGRYLREHVPGVQIVAAE PRYGEGVYALRNIDEGFIPELYDPEILTTRFAVGAYDAIRRTRELVQVEGIFAGISTGAILHAALGMAAR AVKAGERADIAFTVCDAGWKYLSTGAYAGSLDDAEDALEGQLWA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2354 | - | - | 100% (324) | cysteine synthase |
| M. gilvum PYR-GCK | Mflv_2043 | - | 5e-45 | 37.25% (306) | cystathionine beta-synthase |
| M. gilvum PYR-GCK | Mflv_0899 | - | 7e-27 | 30.35% (313) | pyridoxal-5'-phosphate-dependent enzyme, beta subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1371 | cysM | 1e-158 | 84.26% (324) | cysteine synthase B CysM |
| M. tuberculosis H37Rv | Rv1336 | cysM | 1e-158 | 84.26% (324) | cysteine synthase B CysM |
| M. leprae Br4923 | MLBr_00839 | cysK | 4e-51 | 38.14% (312) | putative cysteine synthase |
| M. abscessus ATCC 19977 | MAB_1480 | - | 1e-169 | 88.58% (324) | cysteine synthase |
| M. marinum M | MMAR_4629 | cysM | 1e-126 | 71.01% (307) | cysteine synthase B CysM |
| M. avium 104 | MAV_2052 | cysK | 2e-50 | 37.34% (316) | cysteine synthase A |
| M. smegmatis MC2 155 | MSMEG_4905 | cysM | 1e-168 | 89.51% (324) | cysteine synthase B |
| M. thermoresistible (build 8) | TH_4143 | - | 1e-163 | 86.11% (324) | PUTATIVE cysteine synthase |
| M. ulcerans Agy99 | MUL_0242 | cysM | 1e-126 | 71.01% (307) | cysteine synthase B CysM |
| M. vanbaalenii PYR-1 | Mvan_4291 | - | 1e-170 | 90.43% (324) | cysteine synthases |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1371|M.bovis_AF2122/97 MTRYDSLLQALGNTPLVGLQRLSPRWDDG-RDGPHVRLWAKLEDRNPTGS
Rv1336|M.tuberculosis_H37Rv MTRYDSLLQALGNTPLVGLQRLSPRWDDG-RDGPHVRLWAKLEDRNPTGS
Mflv_2354|M.gilvum_PYR-GCK MTRYDSLLQALGDTPLVGLQRLSPRWNDGEHGEPHVRLWAKLEDRNPTGS
Mvan_4291|M.vanbaalenii_PYR-1 MARYNSLLETLGNTPLVGLQRLSPDWD----GSPHVRLWAKLEDRNPTGS
TH_4143|M.thermoresistible__bu VTRYNSLLESLGNTPLVGLQRLSPRWD----GEPHVRLWAKLEDRNPTGS
MAB_1480|M.abscessus_ATCC_1997 MTRYDSLLQALGNTPLVGLQRLSPRWDSGGDGSPHVRLWAKLEDRNPTGS
MSMEG_4905|M.smegmatis_MC2_155 MTRYDSLLQALGNTPLVGLQNLSPRWDDE-DGKPHVRLWAKLEDRNPTGS
MMAR_4629|M.marinum_M MTRYDSLLATLGDTPLVGLPRLSPGWD----NSPHVRLWAKLEDRNPTGS
MUL_0242|M.ulcerans_Agy99 MTRYDSLLATLGDTPLVGLPRLSPGWD----NSPHVRLWAKLEDRNPTGS
MLBr_00839|M.leprae_Br4923 MSIAEDVTQLVGNTPLVRLRRVT--------EGALADVVAKLESFNPANS
MAV_2052|M.avium_104 MSIAENVTQLIGNTPLVRLNRVT--------EGAVADVVAKLEFFNPGNS
:: :.: :*:**** * .:: . . : **** ** .*
Mb1371|M.bovis_AF2122/97 IKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLIC
Rv1336|M.tuberculosis_H37Rv IKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLIC
Mflv_2354|M.gilvum_PYR-GCK IKDRPALRMIEDAEREGRLHPGATILEPTSGNTGISLAMAALLKGYQMVC
Mvan_4291|M.vanbaalenii_PYR-1 IKDRAALRMIEDAEREGRLQPGVTILEPTSGNTGISLAMAALLKGYQMVC
TH_4143|M.thermoresistible__bu IKDRAALRMIEDAERQGLLSPGATILEPTSGNTGISLAMAARLKGYRLIC
MAB_1480|M.abscessus_ATCC_1997 IKDRPALRMIEQAEQDGLLERGATILEPTSGNTGISMAMAAQLKGYKMIC
MSMEG_4905|M.smegmatis_MC2_155 IKDRPALRMIEQAERDGLLQPGATILEPTSGNTGISLAMAALLKGYNMIC
MMAR_4629|M.marinum_M IKDRPALRMIEQAEADGWLRPGATILEATSGNTGISLAMAAKLKGYRLIC
MUL_0242|M.ulcerans_Agy99 IKDRPALRMIEQAEADGWLRPGATILEATSGNTGISLAMAAKLKGYRLIC
MLBr_00839|M.leprae_Br4923 VKDRIGVAMIDTAEEAGLIKPDTVILEPTSGNTGIALAMVCAARGYHCVL
MAV_2052|M.avium_104 VKDRIGVAMIDAAEQAGLIKPDTIILEPTSGNTGIALALVAAARGYRCVL
:*** .: **: ** * : .. ***.*******::*:.. :**. :
Mb1371|M.bovis_AF2122/97 VMPENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVML
Rv1336|M.tuberculosis_H37Rv VMPENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVML
Mflv_2354|M.gilvum_PYR-GCK VMPENTSIERRQLLELYGARIIYSPAEGGSNTAVAHAKELALQNPSWVML
Mvan_4291|M.vanbaalenii_PYR-1 VMPENTSIERRQLLELYGARIIYSPAEGGSNTAVAYAKEIAAENPSWVML
TH_4143|M.thermoresistible__bu VMPENTSVERRQLLELFGAEIIYSPAEGGSNTAVARAKELAAQNPSWVML
MAB_1480|M.abscessus_ATCC_1997 VMPENTSIERRQLLELYGAQIIFSPAEGGSNTAVATAKELAAQNPSWVML
MSMEG_4905|M.smegmatis_MC2_155 VMPENTSIERRQILELYGARIIFSPAEGGSNTAVATAKELAAQNPSWVML
MMAR_4629|M.marinum_M VIPENTSIERRRLLELYGTEIIFSPAEGGSNTAVALAKQLAAEHPEWVLL
MUL_0242|M.ulcerans_Agy99 VIPENTSIERRRLLELYGTEIIFSPAEGGSNTAVALAKQLAAEHPEWVLL
MLBr_00839|M.leprae_Br4923 TMPETMSIERRMLLRAYGAELILTPGADGMSGAIAKAEELAKSDKRYFIP
MAV_2052|M.avium_104 TMPETMSVERRMLLRALGAEIVLTPGADGMPGAIAKAEELAKSDDRYFVP
.:**. *:*** :*. *:.:: :.. .* *:* *:::* . :.:
Mb1371|M.bovis_AF2122/97 YQYGNPANTDSHYCGTGPELLADLP-EITHFVAGLGTTGTLMGTGRFLRE
Rv1336|M.tuberculosis_H37Rv YQYGNPANTDSHYCGTGPELLADLP-EITHFVAGLGTTGTLMGTGRFLRE
Mflv_2354|M.gilvum_PYR-GCK YQYGNPSNALAHYEGTGPELLADLP-EITHFVAGLGTTGTLMGTGRYLRE
Mvan_4291|M.vanbaalenii_PYR-1 YQYGNPSNAAAHYDGTGPELLADLP-EITHFVGGLGTTGTLMGTGRFLRE
TH_4143|M.thermoresistible__bu YQYGNPANAAAHHDGTGPELLADLP-EITHFVAGLGTTGTLMGTGRFLRE
MAB_1480|M.abscessus_ATCC_1997 YQYGNPANADAHYRGTGPEILADLP-EITHFVAGLGTTGTLMGTGRYLRE
MSMEG_4905|M.smegmatis_MC2_155 YQYGNPANSDAHYFGTGPELLADLP-EITHFVAGLGTTGTLMGTGRFLRE
MMAR_4629|M.marinum_M YQYGNPANSDSHYRGTGPELLADLP-EITHFVAGLGSSGTLMGAGRFLRE
MUL_0242|M.ulcerans_Agy99 YQYGNPANSESHYRGTGPELLADLP-EITHFVAGLGSSGTLMGAGRFLRE
MLBr_00839|M.leprae_Br4923 QQFENPANPAIHAATTAEEVWRDTDGKVDIFVSGIGTGGTITGVARIIKE
MAV_2052|M.avium_104 QQFENPANPAIHRSTTAEEVWRDTDGKVDIFVAGVGTGGTITGVAQVIKE
*: **:*. * *. *: * :: **.*:*: **: *..: ::*
Mb1371|M.bovis_AF2122/97 HVANVKIVAAEPRYG-------EGVYALRNMDEGFVPELYDPEILTARYS
Rv1336|M.tuberculosis_H37Rv HVANVKIVAAEPRYG-------EGVYALRNMDEGFVPELYDPEILTARYS
Mflv_2354|M.gilvum_PYR-GCK HVPGVQIVAAEPRYG-------EGVYALRNIDEGFIPELYDPEILTTRFA
Mvan_4291|M.vanbaalenii_PYR-1 RVPGVQIVAAEPRYG-------EGVYALRNIDEGFIPELYDPDVLTTRFA
TH_4143|M.thermoresistible__bu RVPGVQIVAAEPRYG-------EGVYALRNIDEGFIPELYDPDVLTTRYS
MAB_1480|M.abscessus_ATCC_1997 NVPGVQIVAAEPRYG-------EGVYALRNIDEGFVPELYDPEVLTTRFS
MSMEG_4905|M.smegmatis_MC2_155 HVPGVQIVAAEPRYG-------EGVYALRNIDEGFIPELYDADVLTTRFS
MMAR_4629|M.marinum_M HVANIKIVAVEPRHN-------EKLCGMRNLDEGFVPELYDPTLGAVRYP
MUL_0242|M.ulcerans_Agy99 HVANIKIVAVEPRHN-------EKLCGMRNLDEGFVPELYDPTLGAVRCP
MLBr_00839|M.leprae_Br4923 RRPATQFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPSVLVLDLVDEIVT
MAV_2052|M.avium_104 RKPSAQFIAVEPAASPVLSGGQKGPHPIQGLGAGFVPPVLAMDLVDEVIA
. . :::*.** . : ::.:. **:* : : .
Mb1371|M.bovis_AF2122/97 VGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGALAAGERADIAL
Rv1336|M.tuberculosis_H37Rv VGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGALAAGERADIAL
Mflv_2354|M.gilvum_PYR-GCK VGAYDAIRRTRELVQVEGIFAGISTGAILHAALGMAARAVKAGERADIAF
Mvan_4291|M.vanbaalenii_PYR-1 VGSYDAVRRTRELVHVEGIFAGISTGAILHAALGMAAKAVKAGERADIAF
TH_4143|M.thermoresistible__bu VGSFDAIRRTRELVQTEGIFAGISTGAVLHAALAMAAKAVTAQQRADIAF
MAB_1480|M.abscessus_ATCC_1997 VGSFDAVRRTRELVQVEGIFAGISTGAILHAALGMAAKAVKAGERADIAF
MSMEG_4905|M.smegmatis_MC2_155 VGSFDAVRRTRELVTREGIFAGISTGAVLHAALGMAAKAVKAGERADIAF
MMAR_4629|M.marinum_M VATADAEHRIRELAHTEGVLAGLSTGAALHAALEIGTQALQAGERADIAF
MUL_0242|M.ulcerans_Agy99 VATADAEHRIRELAHTEGVLAGLSTGAALHAALEIGTQALRAGERADIAF
MLBr_00839|M.leprae_Br4923 VGNEEALDLARRLAKEEGLLVGISAGAAVCAALHVARRPENTGK--LIVV
MAV_2052|M.avium_104 VGNEESIALARRLAAEEGLLVGISSGAALVAALQVARRPENAGK--LVVV
*. :: *.*. **::.*:*:** : *** :. . : : :..
Mb1371|M.bovis_AF2122/97 VVADAGWKYLSTGAYAGSLDDAETALEGQLWA-
Rv1336|M.tuberculosis_H37Rv VVADAGWKYLSTGAYAGSLDDAETALEGQLWA-
Mflv_2354|M.gilvum_PYR-GCK TVCDAGWKYLSTGAYAGSLDDAEDALEGQLWA-
Mvan_4291|M.vanbaalenii_PYR-1 TVCDAGWKYLSTGAYAGSLDDAEDALEGQLWA-
TH_4143|M.thermoresistible__bu VVADAGWKYLSTGAYTGSLDEAEDALEGQLWA-
MAB_1480|M.abscessus_ATCC_1997 VVADAGWKYLSTGAYAGTVDDAEDALEGQLWA-
MSMEG_4905|M.smegmatis_MC2_155 VVADAGWKYLSTGAYAGSLDDAEDALEGQLWA-
MMAR_4629|M.marinum_M VVADAAWKYLSSGVY-------EHPAPSKLLAP
MUL_0242|M.ulcerans_Agy99 VVADAAWKYLSSGVY-------EHPARSKLLAP
MLBr_00839|M.leprae_Br4923 VLPDFGERYLSTMLFADLAN-------------
MAV_2052|M.avium_104 VLPDFGERYLSTPLFADLAD-------------
.: * . :***: :