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FVATDAGVDRVIFSASDLAAAARCEYALLRSFDDRLGRGPAVSGDDELLARTATLGDQHEKRHLDELALA SDVTVIGRPAYTVAGLTDAAGQTLRAVERRAPVIYQAAMFDGRFAGFADFLLLEEGPDGQRYRLRDTKLA RSVKVEALLQMAAYVETLTAAGVPVAPEIDLVLGDGTAVSYPVDELLPVYRPRRAALQQLLEDHLAGGRA VEWEDEHVRACFRCAECDTQVRARDDLLLVAGMRVSARARLLDAGITTVHELAAHRGPVAELSSRTVTAL TAQARLQVARRVVENGTEKPPYEIVDPQPLMVLPDADKGDLFFDFEGDPLWTTDGRDWGLEYLWGVLTPG DEFQPFWAHNRTEERQALQDFLKFVRKRRNRYPGMHIYHYAAYEKSALLRLAGRYGVGEHEVDELLRDGV LVDLYPLVRKSIRVGTENYSIKSLEPLYMGNELRDGDVTTATASITEYAHYCELRDDGNAEEAASVLKAI EDYNHYDCRSTRRLRDWLMNRAIECGVPPRGPVRPSPDTDRPRAEVDAVERTLLKFAGDGIEARTPEQRA AAMMAAAKGFHKREDKPFWWGHFDRVNNPVEEWADDSDVFIADRHEIVEDWHTPPRARKPQRHVRLFGEI ANGGLATDMYALYDPPTPEGLSDDPDRRGFASVSVADCDNPEAPTEVVIVERRPTGGDVYTQVPFALTPG APISTALLQNAVADTAALIAAGLPNLPADALTDIFLRRPPRTRSGNPLPRTGGTVADLTAALLDLDSSYL AVHGPPGTGKTYTSGKVIAALLTEHQWKIGVVAQSHAVVENLFGDIMRAGVDGARVGKKRHTVSTGWTEL GRDDYVDFLCQGGCVVGGTAWDFANATKFERECLDLLVIEEAGQFSLANTVAVARAARNLMLLGDPQQLP QVSQGTHPEPVDGSALGWLVDGHATLPPERGYFLDQSFRMHPDVCRAVSRLSYDGRLLSYETVTAARRLD GVAPGVRTLPVSHLGNATESPEEADAIVTEIRRLLGAAWTDAASTDTDATRPLDQTDVLIVTPYNAQVVL LRRRLDAAGLTRVRAGTVDKFQGQQAPVVFVSMTASSIDDVPRGISFLLNRNRLNVAVSRAKYLAVVVRS EHLTDYLPGTPDRLVELGAFLSLTSGTAGVPGSVACDDRHRS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2223 | - | - | 100% (1163) | RecB family-like nuclease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1283c | - | 0.0 | 62.86% (1147) | hypothetical protein Mb1283c |
| M. tuberculosis H37Rv | Rv1251c | - | 0.0 | 62.86% (1147) | hypothetical protein Rv1251c |
| M. leprae Br4923 | MLBr_01098 | - | 0.0 | 62.42% (1147) | hypothetical protein MLBr_01098 |
| M. abscessus ATCC 19977 | MAB_1401c | - | 0.0 | 58.89% (1153) | hypothetical protein MAB_1401c |
| M. marinum M | MMAR_4191 | - | 0.0 | 62.55% (1151) | hypothetical protein MMAR_4191 |
| M. avium 104 | MAV_1388 | - | 0.0 | 64.72% (1145) | ATPase |
| M. smegmatis MC2 155 | MSMEG_5044 | - | 0.0 | 69.70% (1155) | ATPase |
| M. thermoresistible (build 8) | TH_2480 | - | 0.0 | 67.62% (738) | PUTATIVE nuclease (RecB family)-like protein |
| M. ulcerans Agy99 | MUL_4495 | - | 0.0 | 62.38% (1151) | hypothetical protein MUL_4495 |
| M. vanbaalenii PYR-1 | Mvan_4472 | - | 0.0 | 82.52% (1150) | RecB family-like nuclease |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2223|M.gilvum_PYR-GCK ---MFVATDAG-VDRVIFSASDLAAAARCEYALLRSFDDRLGRGPAVS-G
Mvan_4472|M.vanbaalenii_PYR-1 ---MFVATDAD-DVRVIYSASDLAAAARCEYALLRSFDARLGWGPAVS-A
MSMEG_5044|M.smegmatis_MC2_155 ---MFVTEDGGSGPRVIYSASDLAAAARCEYALLRAFDAQLGRGPAVS-S
TH_2480|M.thermoresistible__bu ---MFVA-----ADRVIYSASDLAAAARCEYALLRSFDAELGWGPPVA-V
MLBr_01098|M.leprae_Br4923 ---MFVTD-----ETIVYSASDLAAASRCEYALLRDFDARLGRGPVVATT
MAV_1388|M.avium_104 ---MFVTG-----DSIVYSASDLAAAARCEFALLRDFDAKLGRGPAVT-V
Mb1283c|M.bovis_AF2122/97 ---MFVTG-----DSIVYSASDLAAAARCQYALLREFDAKLGRGPAVA-V
Rv1251c|M.tuberculosis_H37Rv ---MFVTG-----DSIVYSASDLAAAARCQYALLREFDAKLGRGPAVA-V
MMAR_4191|M.marinum_M MAAVFVAD-----DVVVYSASDLAAAARCEFAFLRHFDSKLGRGPAIS-A
MUL_4495|M.ulcerans_Agy99 ---MFVAG-----DVVVYSASDLAAAARCEFAFLRHFDSKLGRGPAIS-A
MAB_1401c|M.abscessus_ATCC_199 ---MFVLD-----DRVVYSASDLASAARCEYALLRVFDAKLGWAPAPP-R
:** :::******:*:**::*:** ** .** .* .
Mflv_2223|M.gilvum_PYR-GCK DDELLARTATLGDQHEKRHLDELALASD-----VTVIGRPAYTVAGLTDA
Mvan_4472|M.vanbaalenii_PYR-1 DDELLARTATLGDEHEQRHLDELRHDTE-----VAVIGRPRYSVSGLTAA
MSMEG_5044|M.smegmatis_MC2_155 EDELLKRTAQLGGEHEQRHLDELREGSE-----ITVIGRPRYTVPGLTAA
TH_2480|M.thermoresistible__bu DDGMLTRTVELGDAHERRHLEALREASDDADDPVTVIGRPAYTVEGLTAA
MLBr_01098|M.leprae_Br4923 EDELFARTSALGADHEQRHLDQLRHEFGD---AVAVIGRPAYTYAGFAAA
MAV_1388|M.avium_104 EDDLLIRTATLGAEHERRELARLRERFGD---AVAVIGRPAYTPAALTAA
Mb1283c|M.bovis_AF2122/97 DDELMARAAVLGSAHEGRRLDQLRHEFGD---AVAIIGRPAYTPAGLAAA
Rv1251c|M.tuberculosis_H37Rv DDELMARAAVLGSAHEGRRLDQLRHEFGD---AVAIIGRPAYTPAGLAAA
MMAR_4191|M.marinum_M EDDLLARTTELGNEHERRTLDRLRDQFG----EIAVIGHPAYTLAGLTAA
MUL_4495|M.ulcerans_Agy99 EDDLLVRTTELGNEHERRTLDRLRDQFG----EIAVIGHPAYTLVGLTAA
MAB_1401c|M.abscessus_ATCC_199 DDELLARTAILGDAHEAHHLSALQARFGAG--VAGIPFPPAFTLEGLQAA
:* :: *: ** ** : * * : * :: .: *
Mflv_2223|M.gilvum_PYR-GCK AGQTLRAVERRAPVIYQAAMFDGRFAGFADFLLLEEGPDGQRYRLRDTKL
Mvan_4472|M.vanbaalenii_PYR-1 AEQTLRAIERRVPVVYQAAMFDGRFAGFADFLILEDSPDGPRYRLRDTKL
MSMEG_5044|M.smegmatis_MC2_155 ANATLAAVTQRAPVIYQAAMFDGRFAGFADFLILSDG----QYRLRDTKL
TH_2480|M.thermoresistible__bu AEATLRAVQRRAPVIYQATMFDGRFVGFADFLVHEPADDGGRYRLRDTKL
MLBr_01098|M.leprae_Br4923 AEATQRAIANRAPAVYQAAMFDGRFVGFIDFLVRDGE----QYRVVDTKL
MAV_1388|M.avium_104 SEATRRAVADRAPVIYQAAMFDGRFLGFADFLVRDGE----RYQVVDTKL
Mb1283c|M.bovis_AF2122/97 ADATRRAIANHAPVVYQAAMFDGRFVGFADFLIRDGH----RYRVADTKL
Rv1251c|M.tuberculosis_H37Rv ADATRRAIANHAPVVYQAAMFDGRFVGFADFLIRDGH----RYRVADTKL
MMAR_4191|M.marinum_M AEATQRAIADRAPVVYQAAMFDGRFVGFADFLIRDRE----RYRITDTKL
MUL_4495|M.ulcerans_Agy99 AEATQRAIADRAPVVYQAAMFDGRFVGFADFLIRDRE----RYRITDTKL
MAB_1401c|M.abscessus_ATCC_199 AAATRRAFEQGYPAVYQAAMFDGRFLGFADFVVREGE----HYLVCDTKL
: * *. *.:***:****** ** **:: . :* : ****
Mflv_2223|M.gilvum_PYR-GCK ARSVKVEALLQMAAYVETLTAAGVPVAPEIDLVLGDGTAVSYPVDELLPV
Mvan_4472|M.vanbaalenii_PYR-1 ARSVKVEALLQMAAYVETLTAAGVPVGPEVDLVLGDGTAVSYPVDELLPV
MSMEG_5044|M.smegmatis_MC2_155 ARSVKVEALLQLAAYSETLSAAGVPVAPEVELVLGDGAVATYPVDELLPV
TH_2480|M.thermoresistible__bu ARSAKVEALLQLAAYAEALIAAGVPVAPEVELVLGDGHTVRYRVDELLPV
MLBr_01098|M.leprae_Br4923 ARSPKVTALLQLAAYADALAHSGVPVAPEAELRLGDGMVVSYRICDLIPV
MAV_1388|M.avium_104 ARSEKVTALLQLAAYADALAAAGVPVAPEAELRLGDGTAVRHRVCDLVPV
Mb1283c|M.bovis_AF2122/97 ARSPTVTALLQLAAYADALVHSGVPVAADAELELGDGTIVRYRVGELIPV
Rv1251c|M.tuberculosis_H37Rv ARSPTVTALLQLAAYADALVHSGVPVAADAELELGDGTIVRYRVGELIPV
MMAR_4191|M.marinum_M ARSPKVTALMQLGAYADALTGAGVPVAPEADLELGDGTVVHFRVSDLIPV
MUL_4495|M.ulcerans_Agy99 ARSPKVTALMQLGAYADALTGAGVPVAPEADLELGDGTAVHFRVSDLIPV
MAB_1401c|M.abscessus_ATCC_199 ARSAKVTALLQLAAYADSLAATGVPVAPSVRLILGDRSAVDYPAADLVGV
*** .* **:*:.** ::* :****... * *** . . :*: *
Mflv_2223|M.gilvum_PYR-GCK YRPRRAALQQLLEDHLAGGRAVEWEDEHVRACFRCAECDTQVRARDDLLL
Mvan_4472|M.vanbaalenii_PYR-1 YRPRRAALQRLLDEHFAGGRAVAWEDEHVRACFRCAECDKQVRAHDDLLL
MSMEG_5044|M.smegmatis_MC2_155 YRPRRAALEHLLDAHLASGEPVSWEDTEIRACFRCPECEVQVRAHDDLLL
TH_2480|M.thermoresistible__bu YAPRRAALERLLDEHLAGGRPVRWEDEEVRACFRCPECRSRVAESDDLLL
MLBr_01098|M.leprae_Br4923 YRSQRSLLQRLLDRHYTAGTAVRWQDDEVRSCFRCPQCTEQLRATDDLLL
MAV_1388|M.avium_104 YRSARARLQRLLDEHRAGGAAVRWDDENVTACFRCAVCVEQLRATDDVLL
Mb1283c|M.bovis_AF2122/97 YRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQCTERLRASDDLLL
Rv1251c|M.tuberculosis_H37Rv YRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQCTERLRASDDLLL
MMAR_4191|M.marinum_M YRAQRAELQRLLDEHYAADTAVCWDDHGVRACFRCELCMEELRRRDDLLL
MUL_4495|M.ulcerans_Agy99 YRAQRAELQRLLDEHYAADTAVCWDDHGVRACFRCELCMEELRRRDDLLL
MAB_1401c|M.abscessus_ATCC_199 YRQRRKQLQDLLDHHLSGGVPVRWSDHHVRACFRCPVCEPEVERTDDLLL
* * *: **: * :.. .* *.* : :**** * .: **:**
Mflv_2223|M.gilvum_PYR-GCK VAGMRVSARARLLDAGITTVHELAAHRG--PVAELSSRTVTALTAQARLQ
Mvan_4472|M.vanbaalenii_PYR-1 VAGMRVSQRARLLDAGITTVQELAAHDG--PVPELSTRAVTALKSQARLQ
MSMEG_5044|M.smegmatis_MC2_155 VAGMRTSQRARLIDAGITTVADLAARRDDEPVEGLHPRIAQGLTAQARLQ
TH_2480|M.thermoresistible__bu VAGMRVSQRARLLDAGITTRTALARHRG--PVPGLPARTVDALTEQARLQ
MLBr_01098|M.leprae_Br4923 IAGMRISQRSKLLNVGITTIAELADHSG--PVPDLSSSALSELTAQAKLQ
MAV_1388|M.avium_104 VAGMRVSQRDKLFDAGISTVAELAAHRG--PVPELAAGVVAKLTAQAKLQ
Mb1283c|M.bovis_AF2122/97 VGGMRVRQRDKLLEAGITTIAELADHTA--PVPGLTTNALGKLTAQAKLQ
Rv1251c|M.tuberculosis_H37Rv VGGMRVRQRDKLLEAGITTIAELADHTA--PVPGLTTNALGKLTAQAKLQ
MMAR_4191|M.marinum_M VAGMRVSQREKLLDAGITTIGGLASHTG--AVPELSANALAKLAAQAKVQ
MUL_4495|M.ulcerans_Agy99 VAGMRVSQREKLLDAGITTIGGLASHTG--AVPELSANALAKLSAQAKVQ
MAB_1401c|M.abscessus_ATCC_199 VAGMRVSQRAALLQAGVGTVAQLATRTE--PVADLSARSLRQLMAQAELQ
:.*** * *::.*: * ** : .* * . * **.:*
Mflv_2223|M.gilvum_PYR-GCK VARRVVENGTEKPPYEIVDPQPLMVLPDADKGDLFFDFEGDPLWTTDGRD
Mvan_4472|M.vanbaalenii_PYR-1 LADRVIENGNVKPPYELVDPQPLMVLPDVDKGDLFFDFEGDPLWTTDGHE
MSMEG_5044|M.smegmatis_MC2_155 RAPRTGK----KPPYEVVDPQPLMSLPNPDRGDLFFDFEGDPLWTDDGVQ
TH_2480|M.thermoresistible__bu IEAGDTG----KPPFVVADPQPLALLPDPDKGDLFFDFEGDPLWTVDGRE
MLBr_01098|M.leprae_Br4923 VQQRNTG----TPQFEIVDPQPLALLPDPDPGDLFFDFEGDPLWTVDGQE
MAV_1388|M.avium_104 VRERETG----VPQVEIVDPQPLALLPEPDPGDLFFDFEGDPLWTADGRE
Mb1283c|M.bovis_AF2122/97 IRQRDTG----APQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQ
Rv1251c|M.tuberculosis_H37Rv IRQRDTG----APQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQ
MMAR_4191|M.marinum_M VQQRDTS----TPQYEISDPQPLALLPEPNPGDLFFDFEGDPLWTADGHE
MUL_4495|M.ulcerans_Agy99 VQQRDTG----APQYEISDPQPLALLPEPNPGDLFFDFEGDPLWTADGHE
MAB_1401c|M.abscessus_ATCC_199 IRQRDSG----TPQFEVADPIPLGTLPAPNPGDVFFDFEGDPLWTEDGVH
* : ** ** ** : **:*********** ** .
Mflv_2223|M.gilvum_PYR-GCK WGLEYLWGVLTPG----DEFQPFWAHNRTEERQALQDFLKFVRKRRNRYP
Mvan_4472|M.vanbaalenii_PYR-1 WGLEYLWGVLSVA----DDFEPLWAHNRSEERQALKDFLALVRKRKRRYP
MSMEG_5044|M.smegmatis_MC2_155 WGLEYMFGVLGTAPRADEDFHPLWAHNRREERQALRDFLALVRKRRKRHP
TH_2480|M.thermoresistible__bu WGLEYLWGVLESG----GRFTALWAHDRAEERRALADFLAFVRKRRRRYP
MLBr_01098|M.leprae_Br4923 WGLEYLFGVLDSEIS--GTFRPLWAHNRVEERKALTEFLKMVTKRRKQRP
MAV_1388|M.avium_104 WGLEYLFGVLEAGPS--GRFRPLWAHNRSEERKALTDFLALVANRRRRRP
Mb1283c|M.bovis_AF2122/97 WGLEYLFGVLEAGRA--GVFRPLWAHDRTAERQALTDFLAIVARRRRRHP
Rv1251c|M.tuberculosis_H37Rv WGLEYLFGVLEAGRA--GVFRPLWAHDRTAERQALTDFLAIVARRRRRHP
MMAR_4191|M.marinum_M WGLEYLFGVLEAGKK--GAFRPLWAHDRRDERKALTDFLALVAKRRKRHP
MUL_4495|M.ulcerans_Agy99 WGLEYLFGVLEAGKK--GAFRPLWAHDRRDERKALTDFLALVAKRRKRHP
MAB_1401c|M.abscessus_ATCC_199 WGLEYLFGVLEYDRSGNEKFRPIWAHDRRTERKALLAFLELVAKRRRRYP
*****::*** * .:***:* **:** ** :* .*:.: *
Mflv_2223|M.gilvum_PYR-GCK GMHIYHYAAYEKSALLRLAGRYGVGEHEVDELLRDGVLVDLYPLVRKSIR
Mvan_4472|M.vanbaalenii_PYR-1 GMHVYHYAAYEKSTLLRLAGRYGVGEHEVDELLRDGVLVDLYPLVRKSIR
MSMEG_5044|M.smegmatis_MC2_155 HMHVYHYAAYEKTALLRLAGRYGEGEDEVDELLRAGVLVDLYPLVRKSIR
TH_2480|M.thermoresistible__bu NMHIYHYAAYEKTTLLRLAGRYGVGEDEVDELLRSGVLVDLFPLVRKSLR
MLBr_01098|M.leprae_Br4923 HMHVYHYAPYEKTALLRLAGRYGVCEDEVDELLRSGTLVDLYPLVSKSIR
MAV_1388|M.avium_104 NMHIYHYAPYEKTALLRLAGRYGVGEDQVDELLRSGTLVDLYPLVRRSIR
Mb1283c|M.bovis_AF2122/97 NMHIYHYAPYEKTALLRLVGRYGIGEDDVDDLLRNGVLVDLYPLVRKSIR
Rv1251c|M.tuberculosis_H37Rv NMHIYHYAPYEKTALLRLVGRYGIGEDDVDDLLRNGVLVDLYPLVRKSIR
MMAR_4191|M.marinum_M NMHIYHYAPYEKTALLRLAGRYGVGEDAIDDLLRNGVLVDLYPVVRKSFR
MUL_4495|M.ulcerans_Agy99 NMHIYHYAPYEKKALLRLAGRYGVGEDAIDDLLRNGVLVDLYPVVRKSFR
MAB_1401c|M.abscessus_ATCC_199 GMHVYHYAAYEKSALLRLAGRYGIGEQQIDDLLRDNILVDLYPVVRKSIR
**:****.***.:****.**** *. :*:*** . ****:*:* :*:*
Mflv_2223|M.gilvum_PYR-GCK VGTENYSIKSLEPLYMGNELRDGDVTTATASITEYAHYCELRDDGNAEEA
Mvan_4472|M.vanbaalenii_PYR-1 VGTENYSIKSLEPLYMGNELRDGEVTTATASITEYARYCALRDEGRTDEA
MSMEG_5044|M.smegmatis_MC2_155 VGTENYSLKSLEPLYMGAQLRDGDVTTATDSITQYGLYCTLRAEGRDDEA
TH_2480|M.thermoresistible__bu VGTENYSLKSLEPLYMGAELRAGDVTTAAESINMYARFTELTAAGRHDEA
MLBr_01098|M.leprae_Br4923 VGAESFSLKALEPLYMGKQLRSGDVTTATDSITCYGRYCELLSAGNFDEA
MAV_1388|M.avium_104 VGADSFSLKALEPLYMGSRLRAGEVTTAAGSITSYARYCELQADGRADEA
Mb1283c|M.bovis_AF2122/97 VGTDSFSLKALEPLYLGTQPRSGDVTTAADSINSYARYCELRAAGRIDEA
Rv1251c|M.tuberculosis_H37Rv VGTDSFSLKALEPLYLGTQPRSGDVTTAADSINSYARYCELRAAGRIDEA
MMAR_4191|M.marinum_M VGAESVSLKALEPLYMGAQLRSGEVTTATDSITSYARYSQLRADGRLDEA
MUL_4495|M.ulcerans_Agy99 VGAESVSLKALEPLYMGAQLRSGEVTTATDSITSYARYSQLRADGRLDEA
MAB_1401c|M.abscessus_ATCC_199 CGSNGYGLKALEPLFIESGKRSGEVTTAVDSINEYARYCALRDNGDPG-A
*::. .:*:****:: * *:****. **. *. : * * *
Mflv_2223|M.gilvum_PYR-GCK ASVLKAIEDYNHYDCRSTRRLRDWLMNRAIECGVPPRGPVRPSPDTDRPR
Mvan_4472|M.vanbaalenii_PYR-1 ATVLKEIEEYNRYDCRSTRRLRDWLMARAIECGVPPRGPVPVTAGQEGAA
MSMEG_5044|M.smegmatis_MC2_155 ALVLKEIEDYNLYDCVSTRKLRDWLINRAIECSVPPLGAQPVGRDT---A
TH_2480|M.thermoresistible__bu RTVLKEIEDYNHYDCRSTRKLRDWLLTLAFESGVPPLGPQPVVTDHT--D
MLBr_01098|M.leprae_Br4923 ATVLKEIEDYNHYDCRSTRELRNWLLLQAYEAGVVPVGAQPVPEGN---T
MAV_1388|M.avium_104 VAVLKEIEDYNHYDCRSTQELRNWLMLRAYESGVLPVGAQPVGDGN---T
Mb1283c|M.bovis_AF2122/97 ATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQPVPDAD---P
Rv1251c|M.tuberculosis_H37Rv ATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQPVPDAD---P
MMAR_4191|M.marinum_M ATVLKEIEDYNHYDCRSTRELRDWLLIRAWEAGVTPIGVQPVPRRD---A
MUL_4495|M.ulcerans_Agy99 ATVLKEIEDYNHYDCRSTRELRDWLLIRAWEAGVTPIGVQPVPRRD---A
MAB_1401c|M.abscessus_ATCC_199 QEVLDSIAEYNRYDCASTRKLRDWLLVRAFEHGITHLSSSSSAAGEQ--P
**. * ** *** **: **:**: * * .: .
Mflv_2223|M.gilvum_PYR-GCK AEV-DAVERTLLKFAGDGI----EARTPEQRAAAMMAAAKGFHKREDKPF
Mvan_4472|M.vanbaalenii_PYR-1 ADSPDPVDRKLLKFAGDGI----EPRTPEQAAVAMLAAAKGFHKREDKPY
MSMEG_5044|M.smegmatis_MC2_155 PEPEDQIARTLRRFVGD------DERTPQQQAVAMIAAARGYHRREDKPF
TH_2480|M.thermoresistible__bu DEEPDDVAAALSAFAGDTV----EQRTAEQTAVALLAAARGYHRRERKPF
MLBr_01098|M.leprae_Br4923 VKDDDELSAILSALSGFTGDVAVGDRTPEQTAIALVAAARGYHRREDKPF
MAV_1388|M.avium_104 VDDRDELVATLSAFTGAAG---IDERTPQQTAVALLAAARGYHRREDKPF
Mb1283c|M.bovis_AF2122/97 IDDGDSLASVLSKFTGDAAA---GERTPEQTAVALLAAARGYHRREDKPF
Rv1251c|M.tuberculosis_H37Rv IDDGDSLASVLSKFTGDAAA---GERTPEQTAVALLAAARGYHRREDKPF
MMAR_4191|M.marinum_M IEDHDELAATLSDFAGDAAA---GNRTAEQTAVALLAAARGYHRREDKPF
MUL_4495|M.ulcerans_Agy99 IEDHDELAATLSDFAGDAAS---GNRTAEQTAVALLAAARGYHRREDKPF
MAB_1401c|M.abscessus_ATCC_199 EQESDEVGRALADFAGDGAP---ADRAPDQTAAAMIAAARGYHNRERKPF
. * : * : * *:.:* * *::***:*:*.** **:
Mflv_2223|M.gilvum_PYR-GCK WWGHFDRVNNPVEEWADDSDVFIADRHEIVEDWHTPPRARKPQRHVRLFG
Mvan_4472|M.vanbaalenii_PYR-1 WWGHFDRVNNPVDEWADDGGVFVAERHEVVADWHQPPRARKPQRHLRLFG
MSMEG_5044|M.smegmatis_MC2_155 WWSHFDRLNHPVEEWSDGAGVFVADTAHVEVDWHTPPRARKPQRWVRLTG
TH_2480|M.thermoresistible__bu WWAHFDRLNNPVDEWGDSSDVFLADNAVVVEDWHKPPRARKLQRHTRLTG
MLBr_01098|M.leprae_Br4923 WWGHFDRLNFPVGEWADNTDVFVADDASIIIDWHTPPRARKPQRRVRLRG
MAV_1388|M.avium_104 WWAHFDRLNFPIDEWADNTDVFVAEQASVCVDWQTPARARKPQRRVRLRG
Mb1283c|M.bovis_AF2122/97 WWAHFDRLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTG
Rv1251c|M.tuberculosis_H37Rv WWAHFDRLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTG
MMAR_4191|M.marinum_M WWSHFDRLNYPIDEWSDSTDVFIVDHASVTVTWHTPARARKPQRRVRLTG
MUL_4495|M.ulcerans_Agy99 WWSHFDRLNYPIDEWSDSTDVFIVDHASVTVTWHTPARARKPQRRVRLTG
MAB_1401c|M.abscessus_ATCC_199 WWSHFDRLNNPVDEWADTAGVFIVESARLVEDWHKSGSQRKLRRHVQVTG
**.****:* *: **.* .**:.. : *: . ** :* :: *
Mflv_2223|M.gilvum_PYR-GCK EIANGGLATDMYALYDPPTPEGLSD-DPDRRGFASVSVADCDNPE-APTE
Mvan_4472|M.vanbaalenii_PYR-1 EIATGELGREMYALYDPPSPAGLSD-DPDRRAFGSVTVTECDDPE-APTE
MSMEG_5044|M.smegmatis_MC2_155 AMAAGELSREMYALYEPPAPSGLTD-DPERRAFGSVQVLEADDAS-APTE
TH_2480|M.thermoresistible__bu TLAAGALGDRVFALYEPPAPRHLTN-DPDRRAAGDADVIAVDDPA-VPTE
MLBr_01098|M.leprae_Br4923 RLARGNLGSAVFALYDPPAPLAMDV-HPGRRAAGRAEVVEADDLS-IPTE
MAV_1388|M.avium_104 ELARGELRTEVFALYDPPAPPGMTD-NPDRRGAGRATVVEADDPA-LPTE
Mb1283c|M.bovis_AF2122/97 ELARGDLNGNVFALYEPPAPPGMTD-NPDRRAAGPAAVVETDDPT-VPTE
Rv1251c|M.tuberculosis_H37Rv ELARGDLNGNVFALYEPPAPPGMTD-NPDRRAAGPAAVVETDDPT-VPTE
MMAR_4191|M.marinum_M ELARGDLKTSVFALYQPPAPPSMTA-DPDLRAAGHAEIVELDDPS-LPTD
MUL_4495|M.ulcerans_Agy99 QLARGDLKTSVFALYQPPAPPSMTA-DPDLRAAGHAEIVELDDPS-LPTD
MAB_1401c|M.abscessus_ATCC_199 DLAGGVLEDSVYALYEPPAPPGLGDGDPDRRASGSATVVEITESGGVPVE
:* * * ::***:**:* : .* *. . . : : *.:
Mflv_2223|M.gilvum_PYR-GCK VVIVERRPTGGDVYTQVPFALTPGAPISTALLQNAVADTAALIAAGLPNL
Mvan_4472|M.vanbaalenii_PYR-1 VVIVERQPKGGDVFPQAPFALTPGPPISTAQLQDAIADTAALVAAGLPNL
MSMEG_5044|M.smegmatis_MC2_155 VLICEREPKEGGTFHQLPFALTPGPPIRTTALQNSIEATAAQIAEGLPRL
TH_2480|M.thermoresistible__bu VVICER-VDDGGQFDQLPFALTPGQLIPTEPLRKSIDDTAAAVAAGLPAL
MLBr_01098|M.leprae_Br4923 VVIVERVGNDGNTFHQLPFALTPGPPIATTALRDSIESTATTLAASLPQL
MAV_1388|M.avium_104 VVVLERVTSDGKPFHQLPFALTPGPPIPTTALRDSIEATVAAVAAGLPRL
Mb1283c|M.bovis_AF2122/97 VVIVERTGSDGNTFQQLPFALAPGPPVPTTALRESIESTAAAVASGSPQL
Rv1251c|M.tuberculosis_H37Rv VVIVERTGSDGNTFQQLPFALAPGPPVPTTALRESIESTAAAVASGSPQL
MMAR_4191|M.marinum_M VVILERTGADGATFQQLPFALTPGPPVPTRALRDSIEATAAAAAAELPRL
MUL_4495|M.ulcerans_Agy99 VVILERTGADGATFQQLPFALTPGPPVPTRALRDSIEATAAAAAAELPRL
MAB_1401c|M.abscessus_ATCC_199 VTIRELTPKNGEVFSAMPMALTPGPPVMTKALEAAIEEVAMGVAHRLPEM
* : * * : *:**:** : * *. :: .. * * :
Mflv_2223|M.gilvum_PYR-GCK PADALTDIFLRRPPRTRSGNPLPR-TGGTVADLTAALLDLDSSYLAVHGP
Mvan_4472|M.vanbaalenii_PYR-1 PADGLTDILLRRPPRTRSGGPLPR-TGDAVADITAALLDLDSSYLAVHGP
MSMEG_5044|M.smegmatis_MC2_155 PGNAVVDILLRRPPRTRSGGPLPHGQAAKHELITAALLDLDSSYLAVHGP
TH_2480|M.thermoresistible__bu PDTAVVDLLARRTPRRXX--------------------------------
MLBr_01098|M.leprae_Br4923 PRTALIDILLRRIPRTHSGATLPR-GTDTVADITAAVLDLDSSYLAVHGP
MAV_1388|M.avium_104 PDSAVVDVLLRRAPRTRSGAALPR-SADTVADIASALTDLDSSYLAVHGP
Mb1283c|M.bovis_AF2122/97 PSTALMDVLLRRPPRTRSGAALPR-SSDPVTDIAAAALDLDSSYLAVHGP
Rv1251c|M.tuberculosis_H37Rv PSTALMDVLLRRPPRTRSGAALPR-SSDPVTDIAAAALDLDSSYLAVHGP
MMAR_4191|M.marinum_M PRTALIDVLLRCPPRTRSAAPLPR-SGNTVADITAAVLDLDSSYLAVHGP
MUL_4495|M.ulcerans_Agy99 PRTALIDVLLRCPPRTRSAAPLPR-SGDTVADITAAVLDLDSSYLAVHGP
MAB_1401c|M.abscessus_ATCC_199 PRTASLDILLRRNP--RGGPLPPVDAGGYAGAITSALRALDSSYLAVHGP
* . *:: * *
Mflv_2223|M.gilvum_PYR-GCK PGTGKTYTSGKVIAALLTEHQWKIGVVAQSHAVVENLFGDIMRAGVDGAR
Mvan_4472|M.vanbaalenii_PYR-1 PGTGKTHTSAQVIATLVGRHGWTVGVVAQSHAVVENLFTDVMRAGVDGTR
MSMEG_5044|M.smegmatis_MC2_155 PGTGKTFTSAAVIARLVNRHHWRIGVVAQAHAVVENLFRDVIAADVPADA
TH_2480|M.thermoresistible__bu -----------------------XDVAALDDAAVN---------------
MLBr_01098|M.leprae_Br4923 PGTGKTHTAAHVITQLVSNHSWRIGVVAQSHAAVENLLDGVITAGLDARQ
MAV_1388|M.avium_104 PGTGKTHTAARVIVRLVAEHRWRVGVVAQSHATVENLLDCVIDAGLDPRR
Mb1283c|M.bovis_AF2122/97 PGTGKTYTAARVIAELVTEHAWRIGVVAQSHATVENLLEGVISAGLDPGQ
Rv1251c|M.tuberculosis_H37Rv PGTGKTYTAARVIAELVTEHAWRIGVVAQSHATVENLLEGVISAGLDPGQ
MMAR_4191|M.marinum_M PGTGKTHTAARVIGRLVQEHCWRVGVVAQSHATVENLLDCVIDAGLDPAR
MUL_4495|M.ulcerans_Agy99 PGTGKTHTAARVIGRLVQEHCWRVGVVAQSHATVENLLDCVIDAGLDPAR
MAB_1401c|M.abscessus_ATCC_199 PGTGKTFTAARVIADLVTQDRWLVGVVAQSHAVVEHLLDQVVAAGVPADR
.*.* .*.*:
Mflv_2223|M.gilvum_PYR-GCK VGKKR---HTVSTGWTELGRDDYVDFLCQG---GCVVGGTAWDFANATKF
Mvan_4472|M.vanbaalenii_PYR-1 IGKKAHTAHTVSGGWTELDRDDYAEFLRQD---GCVVGGTAWDFANDNKF
MSMEG_5044|M.smegmatis_MC2_155 VAKKP---HGDNACWTELSEKEYPDFLDQHTGTGCVIGGTAWDFANPVRI
TH_2480|M.thermoresistible__bu --------------------------------------------------
MLBr_01098|M.leprae_Br4923 VAKKR--HDRSAPPWQEIDGNDYPTFIADP--MGCVIGGTAWDFANRNRV
MAV_1388|M.avium_104 IAKKR--YDRQAPRWQEIDGNAYAAFLADT--PGCVIGGTAWDFANANRI
Mb1283c|M.bovis_AF2122/97 VAKKP--HDHTAGRWQSIDGSQYTEFIRDT--AGCVIGGTAWDFANGNRV
Rv1251c|M.tuberculosis_H37Rv VAKKP--HDHTAGRWQSIDGSQYTEFIRDT--AGCVIGGTAWDFANGNRV
MMAR_4191|M.marinum_M IAKKR--YDHGAPRWQEIDGNHYAAFIADH--PGCVVGGTAWDFANGNRV
MUL_4495|M.ulcerans_Agy99 IAKKR--YDHGAPRWQEIDSNHYAAFIADH--PGCVVGGTAWDFANGNRV
MAB_1401c|M.abscessus_ATCC_199 VAKKAS-PYSGDAAWTQIRDSDYARFIADHTGQGAVIGGTAWDFANATRV
Mflv_2223|M.gilvum_PYR-GCK ERECLDLLVIEEAGQFSLANTVAVARAARNLMLLGDPQQLPQVSQGTHPE
Mvan_4472|M.vanbaalenii_PYR-1 TRGCLDLLVIEEAGQFSLANTVAVSRAARNLLLLGDPQQLPQVSQGTHPE
MSMEG_5044|M.smegmatis_MC2_155 PPGSLDLLVVEEAGQYSLANTIAVAPAAHNLLLLGDPQQLPQVSQGTHPE
TH_2480|M.thermoresistible__bu --------------------------------------ELPGEPTGPEPP
MLBr_01098|M.leprae_Br4923 PPGSLDLLVIDEAGQFCLANTIAVAPAAANLMLLGDPQQLPQVSQGTHPE
MAV_1388|M.avium_104 PPGSLDLLVIDEAGQFCLANTIAVAPAAANLLLLGDPQQLPQVSQGTHPE
Mb1283c|M.bovis_AF2122/97 PKASLDLLVIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPE
Rv1251c|M.tuberculosis_H37Rv PKASLDLLVIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPE
MMAR_4191|M.marinum_M PPGSLDLLVVDEAGQFCLANTVAVAPAAANLLLLGDPQQLPQVSQGKHPE
MUL_4495|M.ulcerans_Agy99 PPGSLDLLVVDEAGQFCLANTVAVAPAAANLLLLGDPQQLPQVSEGKHPE
MAB_1401c|M.abscessus_ATCC_199 ADDALELLVIDEAGQFSLANTLAVARGARNLLLLGDPQQLPQVSQGVHPE
:** . * .*
Mflv_2223|M.gilvum_PYR-GCK PVDGSALGWLVDGHATLPPERGYFLDQSFRMHPDVCRAVSRLSYDGRLLS
Mvan_4472|M.vanbaalenii_PYR-1 PVDGSALGWLVDGHHTLPPERGYFLDRSYRMHPDVCRAVSRLSYDGRLLS
MSMEG_5044|M.smegmatis_MC2_155 PVDTSALGWLVDGHHTLPAELGYFLDCSYRMHPAVCAAVSRLSYDNRLRS
TH_2480|M.thermoresistible__bu PLT-----------------------------------------------
MLBr_01098|M.leprae_Br4923 PVNTSALDWLVEGQRTLPNERGYFLDRSYRMHPAICAAVSTLSYEGKLHA
MAV_1388|M.avium_104 PVDTSALDWLVDGQRTLPDERGYFLDRSYRMHPAVCAAVSALSYEGRLHS
Mb1283c|M.bovis_AF2122/97 PVDTSALSWLVDGQHTLPDERGYFLDRSYRMHPAVCAAVSALSYEGRLCS
Rv1251c|M.tuberculosis_H37Rv PVDTSALSWLVDGQHTLPDERGYFLDRSYRMHPAVCAAVSALSYEGRLCS
MMAR_4191|M.marinum_M PVDVSALEWLVDGQRTLPEERGYFLDRSFRMHPAVCHAVSMLSYAGKLHS
MUL_4495|M.ulcerans_Agy99 PVDVSALEWLVDGQRTLPEERGYFLDRSFRMHPAVCHAVSMLSYAGKLHS
MAB_1401c|M.abscessus_ATCC_199 PVDTSALGWLVEGHGALPASRGYFLERSYRMHPALCQYVSRLSYDGELES
*:
Mflv_2223|M.gilvum_PYR-GCK YETVTAARRLDGVAPGVRTLPVSHLGNATESPEEADAIVTEIRRLLGAAW
Mvan_4472|M.vanbaalenii_PYR-1 NEHVTAARRLDGVTPGVRTLEVDHLGNATESPEEADAIVTAITGLLATPW
MSMEG_5044|M.smegmatis_MC2_155 VDDVTAARHLDGQEPGVHVLLVDHDGNATDSPEEAQVIVAEIRRLLGAAW
TH_2480|M.thermoresistible__bu -DDGTSGTTPVGDGAGARTGGM----------------------------
MLBr_01098|M.leprae_Br4923 HTEYTAARRLNEYQPGVHVLAVHHQGNSTESPEEAGAITAEIERLLGTPW
MAV_1388|M.avium_104 -DACTAARRLDGCPPGVRLLSVDHQGNSTESPEEADAIAAAVTGLLGASW
Mb1283c|M.bovis_AF2122/97 HTERTAVRRLDGYPPGVHTRGVHHKGNSIESPEEAEAILAELRQLLGSPW
Rv1251c|M.tuberculosis_H37Rv HTERTAVRRLDGYPPGVHTRGVHHKGNSIESPEEAEAILAELRQLLGSPW
MMAR_4191|M.marinum_M HTERTTARRLSASPPGVHVLAVEHQGNSIESAEEAEAILAQIQRLLGSPW
MUL_4495|M.ulcerans_Agy99 HTERTTARRLSASPPGVHVLAVEHQGNSIESAEEAEAILAQIQRLLGSPW
MAB_1401c|M.abscessus_ATCC_199 ---AAPERSLAGQPPGVRTLLVDHEGNATSSPQEAEAIATEIARLIGSDW
:. .*.: :
Mflv_2223|M.gilvum_PYR-GCK TDAASTDTDATRPLDQTDVLIVTPYNAQVVLLRRRLDAAGLT---RVRAG
Mvan_4472|M.vanbaalenii_PYR-1 TDEG-----GTRPLAQRDVLIVTPYNAQVVLVRRRLDAAGLT---EVRAG
MSMEG_5044|M.smegmatis_MC2_155 TDER-----GTVPLGQDHVLVVTPYNAQVVTMRRYLDAAGLT---DVRVG
TH_2480|M.thermoresistible__bu --------------------------------------------------
MLBr_01098|M.leprae_Br4923 TDEH-----GTRPLDVSDILVLAPYNAQVALVRQQLMSAGFS---GVRVG
MAV_1388|M.avium_104 TDEH-----GTRALTASDVLVLAPYNAQVALLRRRLGSAGLD---GVRVG
Mb1283c|M.bovis_AF2122/97 TDEH-----GTRPLAASDVLVLAPYNAQVALVRRRLASAGLGGADGVRVG
Rv1251c|M.tuberculosis_H37Rv TDEH-----GTRPLAASDVLVLAPYNAQVALVRRRLASAGLGGADGVRVG
MMAR_4191|M.marinum_M TDEH-----GTRPLATHDLLVLAPYNAQVALIRQRLLSAGLN---GVRVG
MUL_4495|M.ulcerans_Agy99 TDEH-----GTRPLATRDLLVLAPYNAQVALIRQRLLSAGLN---GVRVG
MAB_1401c|M.abscessus_ATCC_199 TDES-----GTRPLEQSDVLVVAPYNAQVLTLRATLAAAGLG---EVLVG
Mflv_2223|M.gilvum_PYR-GCK TVDKFQGQQAPVVFVSMTASSIDDVPRGISFLLNRNRLNVAVSRAKYLAV
Mvan_4472|M.vanbaalenii_PYR-1 TVDKFQGQQAPVVFVSMTASSIDDVPRGIAFLLNRNRLNVAVSRAKYLAV
MSMEG_5044|M.smegmatis_MC2_155 TVDKFQGQQAPVVFISMVASSVDDVPRGISFLLNRNRLNVAVSRAKYAAV
TH_2480|M.thermoresistible__bu --------------------------------------------------
MLBr_01098|M.leprae_Br4923 TVDKFQGGQAPVVFISMTSSSVEVVPRGISFLLNRNRLNVAVSRAQYAAV
MAV_1388|M.avium_104 TVDKFQGGQAPVVFISMTASSVDVVPRGISFLLNRNRLNVAVSRAQYAAV
Mb1283c|M.bovis_AF2122/97 TVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAAV
Rv1251c|M.tuberculosis_H37Rv TVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAAV
MMAR_4191|M.marinum_M TVDKFQGAQAPVVFVSMTASAVDDVPRGISFLLNRNRLNVAISRAQYAAV
MUL_4495|M.ulcerans_Agy99 TVDKFQGAQAPVVFVSMTASSVDDVPRGISFLLNRNRLNVAISRAQYAAV
MAB_1401c|M.abscessus_ATCC_199 TVDKFQGRQAPVVFVSMTASAVDDVPRGMSFLLNRNRLNVAISRAKFQAV
Mflv_2223|M.gilvum_PYR-GCK VVRSEHLTDYLPGTPDRLVELGAFLSLTSGTAGVPGSVACDDRHRS
Mvan_4472|M.vanbaalenii_PYR-1 IVRSQHLTDYLPGTPDGLVQLGAFLSLAT----------CDTPTE-
MSMEG_5044|M.smegmatis_MC2_155 IVRSAALTEYLPSTPAGVVELGAFLALPDALP--------DALNTV
TH_2480|M.thermoresistible__bu ----------------------------------------------
MLBr_01098|M.leprae_Br4923 IVRSETLTEYLPATPVGLIDLGAFLTLTTFNGTGRLESRLDKP---
MAV_1388|M.avium_104 IVRSPTLTEYLPGTPAGLIELGAFLALTQPDLR-------------
Mb1283c|M.bovis_AF2122/97 IVRSELLTQYLPATPDGLVDLGAFLGLTSTS---------------
Rv1251c|M.tuberculosis_H37Rv IVRSELLTQYLPATPDGLVDLGAFLGLTSTS---------------
MMAR_4191|M.marinum_M IVRSELLTRYLPGTPAGLVDLGAFLALTEPG---------------
MUL_4495|M.ulcerans_Agy99 IVRSELLTRYLPGTPAGLVDLGAFLALTEPA---------------
MAB_1401c|M.abscessus_ATCC_199 IVRSPALTEYLPTTPDGLVELGAFLALSPDKTFS------------