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TSEMDHVPDRPDTWQAAFDLIRTRGHERREEPFKLASGQLSHDYIDGKYAVDTGERLTIVSQAVADLAAM KGIEFDAVGGLTMGADPLAHGVAMVTGKAWFSVRKEQKKRGREQWVEGTRLGPGTRVLLVDDVISTGGST ELALERIAPLGVVVVGVIPMVDRGDVATARFAKRNVPFHALVTYRDLGIEPVADV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1084 | - | - | 100% (196) | orotate phosphoribosyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0389c | pyrE | 8e-16 | 31.01% (158) | orotate phosphoribosyltransferase |
| M. tuberculosis H37Rv | Rv0382c | pyrE | 8e-16 | 31.01% (158) | orotate phosphoribosyltransferase |
| M. leprae Br4923 | MLBr_02487 | pyrE | 1e-15 | 31.85% (157) | orotate phosphoribosyltransferase |
| M. abscessus ATCC 19977 | MAB_4260c | pyrE | 2e-15 | 33.12% (157) | orotate phosphoribosyltransferase |
| M. marinum M | MMAR_0649 | pyrE | 7e-15 | 30.57% (157) | orotate phosphoribosyltransferase PyrE |
| M. avium 104 | MAV_4790 | pyrE | 2e-15 | 30.57% (157) | orotate phosphoribosyltransferase |
| M. smegmatis MC2 155 | MSMEG_6520 | - | 6e-89 | 83.42% (187) | orotate phosphoribosyltransferase |
| M. thermoresistible (build 8) | TH_2135 | - | 6e-83 | 78.12% (192) | orotate phosphoribosyltransferase |
| M. ulcerans Agy99 | MUL_0123 | pyrE | 5e-15 | 30.57% (157) | orotate phosphoribosyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5738 | - | 2e-99 | 95.19% (187) | orotate phosphoribosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0649|M.marinum_M ----MAVR---------EREELAELVRRLAVVHG--RVTLSSGKEADYYV
MUL_0123|M.ulcerans_Agy99 ----MAVR---------EREELAELVRQLAVVHG--RVTLSSGKEADYYV
MAV_4790|M.avium_104 ----MAEP---------ELEELAELVRRLSVVHG--RVTLSSGKEADYYV
Mb0389c|M.bovis_AF2122/97 ----MAGP---------DRAELAELVRRLSVVHG--RVTLSSGREADYYV
Rv0382c|M.tuberculosis_H37Rv ----MAGP---------DRAELAELVRRLSVVHG--RVTLSSGREADYYV
MLBr_02487|M.leprae_Br4923 ----MAEL---------DRKELADLVRRLSVVQG--CVTLSSGKQADHYV
MAB_4260c|M.abscessus_ATCC_199 ----MAELDLGPDLNAADRDELAALVRDIAVVHG--KVTLSSGKEADYYV
Mflv_1084|M.gilvum_PYR-GCK MTSEMDHVPDRPD----TWQAAFDLIRTRGHERREEPFKLASGQLSHDYI
Mvan_5738|M.vanbaalenii_PYR-1 -MPGMPADTDRPQ----TWQAAFDLIRTRGHERREEPFKLASGQLSHDYI
MSMEG_6520|M.smegmatis_MC2_155 ----MPAAIERPD----TWQAAFNLIRTRGYEHREEPFRLASGQLSHDYI
TH_2135|M.thermoresistible__bu ----MTAAPDRPA----SWQEAFELIRTRGYERRAEPFRLASGQLSHDYI
* *:* . : . *:**: :. *:
MMAR_0649|M.marinum_M DLRRATLHHRAAALVGSLMRELT--QDWDYAVVGGLTLGADPVATAMMHA
MUL_0123|M.ulcerans_Agy99 DLRRATLHHRAAALVGSLMRELT--QDWDYAVVGGLTLGADPVATAMMHA
MAV_4790|M.avium_104 DLRRATLHHRASALIGRLMRELT--SDWDYAVVGGLTLGADPVATAIMHA
Mb0389c|M.bovis_AF2122/97 DLRRATLHHRASALIGRLMRELT--ADWDYSVVGGLTLGADPVATAIMHA
Rv0382c|M.tuberculosis_H37Rv DLRRATLHHRASALIGRLMRELT--ADWDYSVVGGLTLGADPVATAIMHA
MLBr_02487|M.leprae_Br4923 DLRRATLHHRASALIGRLMRELT--KDWNYTVVGGLTLGADPVAIAIIHS
MAB_4260c|M.abscessus_ATCC_199 DLRRATLHHRAGALIGRLVRELT--ADWDYAGVGGLTLGADPVATAVMHA
Mflv_1084|M.gilvum_PYR-GCK DGKYAVDTGERLTIVSQAVADLAAMKGIEFDAVGGLTMGADPLAHGVAMV
Mvan_5738|M.vanbaalenii_PYR-1 DGKYAVDTGERLTIVSRAVADLAAAKGIEFDAVGGLTMGADPLAHGVAMV
MSMEG_6520|M.smegmatis_MC2_155 DGKYAIDTGERMRIVSEAVADLAKAMGIEYDAVGGLTMGADPLAHGVAMV
TH_2135|M.thermoresistible__bu DGKYAVDTGTRLELVSRAVVELAAAHDIEFDAVGGLTMGADPLAHGIAIV
* : * ::. : :*: . :: *****:****:* .:
MMAR_0649|M.marinum_M PGRPIDAFVVRKAAKVHGMQRLIEGSEVS-GKQVLVVEDTSTTGNSALTA
MUL_0123|M.ulcerans_Agy99 PGRPIDAFVVRKAAKVHGMQRLIEGSEVS-GKQVLVVEDTSTTGNSALTA
MAV_4790|M.avium_104 PGRPIDAFVVRKSAKTHGLQRLIEGSEVA-GKRVLVVEDTSTTGNSALTA
Mb0389c|M.bovis_AF2122/97 PGRPIDAFVVRKSAKAHGMQRLIEGSEVT-GQRVLVVEDTSTTGNSALTA
Rv0382c|M.tuberculosis_H37Rv PGRPIDAFVVRKSAKAHGMQRLIEGSEVT-GQRVLVVEDTSTTGNSALTA
MLBr_02487|M.leprae_Br4923 PGRPIDAFVVRKYAKTHGLQRLIEGSEVS-GQRVLVVEDTSTTGASALTA
MAB_4260c|M.abscessus_ATCC_199 PGRPIDAFVVRKSVKTHGMQRLIEGFDVV-GQQVLVVEDTSTTGGSALTA
Mflv_1084|M.gilvum_PYR-GCK TGK--AWFSVRKEQKKRGREQWVEGTRLGPGTRVLLVDDVISTGGSTELA
Mvan_5738|M.vanbaalenii_PYR-1 TGK--AWFSVRKEQKKRGREQWVEGTRLEPGMRVLLVDDVISTGGSTELA
MSMEG_6520|M.smegmatis_MC2_155 TGK--AWFSVRKEQKSRGREQWIEGTRLEPGTRVLLVDDVISTGGSTEIA
TH_2135|M.thermoresistible__bu TGK--AWFSVRKEQKSRGREQWIEGTRLAPGTRVLLVDDVISTGGSTLQA
.*: * *** * :* :: :** : * :**:*:*. :** *: *
MMAR_0649|M.marinum_M VHAVQDAGGEVIGVATVVDRATGAAEAIQAEGLPYRSVLGLADLGLG---
MUL_0123|M.ulcerans_Agy99 VHAVQDAGGEVIGVTTVVDRATGAAEAIQAEGLPYRSVLGLADLGLG---
MAV_4790|M.avium_104 VRAVQQAGGQVLGVATVVDRATGAAEAIEAEGLPYRSVLGLADLGLG---
Mb0389c|M.bovis_AF2122/97 VHAVQDVGGEVVGVATVVDRATGAAEAIEAEGLRYRSVLGLADLGLD---
Rv0382c|M.tuberculosis_H37Rv VHAVQDVGGEVVGVATVVDRATGAAEAIEAEGLRYRSVLGLADLGLD---
MLBr_02487|M.leprae_Br4923 VRAVQDAGGDVVGVATVVDRGTGAAEAIKAEGLLYRSVLGLADLGLG---
MAB_4260c|M.abscessus_ATCC_199 VHAVRQAGGEVIGVATVVDRDTGAAEAIRAEGVPYRYVLGLADLGLAGS-
Mflv_1084|M.gilvum_PYR-GCK LERIAPLGVVVVGVIPMVDRGDVATARFAKRNVPFHALVTYRDLGIEPVA
Mvan_5738|M.vanbaalenii_PYR-1 LERIAPLGVVVTGVIPMVDRGDVAAGRFAKRNVPFHALVTYRDLGIEPVK
MSMEG_6520|M.smegmatis_MC2_155 YDRVTAAGAVVSGVIPMVDRGDIAAGRFAKRGVPFAALVTYRDLGIEPVK
TH_2135|M.thermoresistible__bu YERVTEAGAVVTGVIPMVDRGDSAARLFAERGVPFVALVTYRDLGIEPVQ
: * * ** .:*** *: : ..: : :: ***:
MMAR_0649|M.marinum_M ------
MUL_0123|M.ulcerans_Agy99 ------
MAV_4790|M.avium_104 ------
Mb0389c|M.bovis_AF2122/97 ------
Rv0382c|M.tuberculosis_H37Rv ------
MLBr_02487|M.leprae_Br4923 ------
MAB_4260c|M.abscessus_ATCC_199 ------
Mflv_1084|M.gilvum_PYR-GCK DV----
Mvan_5738|M.vanbaalenii_PYR-1 DV----
MSMEG_6520|M.smegmatis_MC2_155 DV----
TH_2135|M.thermoresistible__bu AVDPAT