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NIQRYAAAFLALAVSIAGCAPAESPPAPDWGPELAKRVVIDNVYGHLVTLQEIADAHDGNRADGSPGYQA SVDYVAQALRDKGFDVQTPEFERLSGSRGGAPALTVAGRGFRVEQASLKITTPPGGLRAITLRPRRPAGC TAADYREVSVDKAIAVVDDSGCSVVQKQRVAVGEGAVGVLVVSAATPSRPVGAPPTLFTPGYYNDLTVPV GVIDPTADAALRRTEAPVTLVLDNKPVMTTSRNVIAQTRTGDPGNIVMVGAHLDSAASGPGINDNGSGVA AVLETALQLGAQPQTANAVRFAFWGAEEISLDGSKAYLRSLERDQLNDIALYLNFDMLGSINAGYFTDDG DQSTQMEPDFVVAPEGSAGIERTLAGSLLLAGVRPADIPLTRTTDYAPFLAAGIPVGGLTTGSSQRKTEV QGRLWGGEAGVPFDPNYHTRRDDIDNVDRTALGRMASSAAFAVGTYADALDGVNGVPERDRRDRRTP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0189 | - | - | 100% (488) | aminopeptidase Y |
| M. gilvum PYR-GCK | Mflv_0190 | - | e-111 | 47.69% (497) | aminopeptidase Y |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0426 | lpqL | 1e-107 | 45.31% (501) | lipoprotein aminopeptidase LpqL |
| M. tuberculosis H37Rv | Rv0418 | lpqL | 1e-107 | 45.31% (501) | lipoprotein aminopeptidase LpqL |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4212c | - | 1e-134 | 52.85% (492) | lipoprotein aminopeptidase LpqL |
| M. marinum M | MMAR_0727 | lpqL_1 | 1e-148 | 57.38% (488) | lipoprotein aminopeptidase LpqL_1 |
| M. avium 104 | MAV_4737 | - | 1e-158 | 59.88% (486) | peptidase, M28 family protein |
| M. smegmatis MC2 155 | MSMEG_0807 | - | 1e-171 | 63.52% (488) | leupeptin-inactivating enzyme 1 |
| M. thermoresistible (build 8) | TH_2315 | lpqL | 1e-113 | 47.26% (493) | PROBABLE LIPOPROTEIN AMINOPEPTIDASE LPQL |
| M. ulcerans Agy99 | MUL_3587 | lpqL | 1e-107 | 47.31% (465) | lipoprotein aminopeptidase LpqL |
| M. vanbaalenii PYR-1 | Mvan_0716 | - | 0.0 | 78.33% (480) | aminopeptidase Y |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0189|M.gilvum_PYR-GCK ---MNIQR---YAAAFLALAVSIAGCAPA------------ESPPAPDWG
Mvan_0716|M.vanbaalenii_PYR-1 ---MTSRRS--GLGALVAVCALVVSCSSG------------LQAPVAGLG
MSMEG_0807|M.smegmatis_MC2_155 ---MTRRRLAAALATAAAVAVTAVACSQE------------PAAPSNELP
MMAR_0727|M.marinum_M MIRATVQRF----GATLVLACALAGCAAPKSL---------PPTAAPDLS
MAV_4737|M.avium_104 ---MTVRLG----ATLLWIAVLLAGCSSAGPG---------LPTAAPDLG
MAB_4212c|M.abscessus_ATCC_199 -MALFSARGLARGCSLLAIAAVASCCAHPSTPGAA-----APTAPNPNLA
Mb0426|M.bovis_AF2122/97 -MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSR----PVVNGPAAAEFA
Rv0418|M.tuberculosis_H37Rv -MVNKSRMMPAVLAVAVVVAFLTTGCIRWSTQSR----PVVNGPAAAEFA
MUL_3587|M.ulcerans_Agy99 -MVKKSRTMPAMVAVA-VVAFLVVGCVRWSTQTQTQPQPAISNPAAAEFA
TH_2315|M.thermoresistible__bu ------LTAGALMTAMAVFGTAVVGGCSRSTQTEP---VPGAAPAAADFA
. ..
Mflv_0189|M.gilvum_PYR-GCK PELAKRVVIDNVYGHLVTLQEIADAHDGNRADGSPGYQASVDYVAQALRD
Mvan_0716|M.vanbaalenii_PYR-1 PELADKVTIDGVYGHLGKFQEIADANDGNRADGSPGYQASVDYVAQLLRD
MSMEG_0807|M.smegmatis_MC2_155 HDLAQAVTVDAMFGHLRKLQEIADANGGNRAQGTPGYDASLDYVAGLLRD
MMAR_0727|M.marinum_M RDLAAKVTGDGMFAHLRALQTVADSNGGNRATGTPGYDASLDYVVKALKA
MAV_4737|M.avium_104 HGLAKKVTADAMMAHLRALQNIANANGGNRADGTPGFQASVDYVAKALRD
MAB_4212c|M.abscessus_ATCC_199 ADLARSVTVDAMMVHLQQLQQVADANGGNRAEGTSGYDASADYVAKVLKD
Mb0426|M.bovis_AF2122/97 VALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRN
Rv0418|M.tuberculosis_H37Rv VALRNRVSTDAMMAHLSKLQDIANANDGTRAVGTPGYQASVDYVVNTLRN
MUL_3587|M.ulcerans_Agy99 EALRNRVTTEAMMGHLTKLQEIADANNGTRAVGTPGYEASVDYVVNILRN
TH_2315|M.thermoresistible__bu AELRDRISGDAVFAHLTELQRIADEHGGNRALGTPGYDASVDYVVDVLRD
* : : : ** :* :*: :.*.** *:.*::** ***. *:
Mflv_0189|M.gilvum_PYR-GCK KGFDVQTPEFERLSGSRGGAPALTVAGRGFRVEQASLKITTPPGGLRAIT
Mvan_0716|M.vanbaalenii_PYR-1 KGFDVQTPEFQRLSGSEGGKPSLTVAGRQFRVDQASLLLTTPPGGLKAIT
MSMEG_0807|M.smegmatis_MC2_155 KGFEVETPEFERLGTVGGGNPSLTVSSQRFSVEQASLLVPTPDGGLNAPT
MMAR_0727|M.marinum_M KGFEVTTPEFQRLYTVSEGKPTLTVAGRSYSVDQASLLVQTPPGGLAGPP
MAV_4737|M.avium_104 KGFDVQTPQFDRLYPVSPGKPTLTVAGRGYPVDQASMLVQTPPGGLTGPA
MAB_4212c|M.abscessus_ATCC_199 RGFEVQTPELSRLKVLSEGKPLVDIGGRPYALDQASYFAQTPKGGLKANI
Mb0426|M.bovis_AF2122/97 SGFDVQTPEFSARVFKAE-KGVVTLGGNTVEARALEYSLGTPPDGVTGPL
Rv0418|M.tuberculosis_H37Rv SGFDVQTPEFSARVFKAE-KGVVTLGGNTVEARALEYSLGTPPDGVTGPL
MUL_3587|M.ulcerans_Agy99 SGFDVQTPEFSARVFHSE-KGSVDVGGMTAEAHALEYSLGTPPDGVTGPL
TH_2315|M.thermoresistible__bu SGFEVETPEFEVRLPFAE-DPEVTVGGAPVSAKPLLFTIGTGPDGVSGPL
**:* **::. : :.. * .*: .
Mflv_0189|M.gilvum_PYR-GCK LRPR-RP--AGCTAADYREVSVDKAIAVVDDSGCSVVQKQRVAVGEGAVG
Mvan_0716|M.vanbaalenii_PYR-1 LRPR-RP--AGCTAADYGDVSVAKAIAVVDDAGCSIVTKQRVAVAEGAVG
MSMEG_0807|M.smegmatis_MC2_155 LRPG-KP--AGCAASDYKGVTVKGAISVVDDTGCSIVVKQNVALAEGAVG
MMAR_0727|M.marinum_M VRPS-RS--DGCAVADYPPALPDNAIAVVDDTGCSVVDKHNSAVAKGAAG
MAV_4737|M.avium_104 VRPA-QP--SGCAASDYPGALPKGAIAVVDDTRCSVVDKQNSAVARGASA
MAB_4212c|M.abscessus_ATCC_199 IRPSGKA--SGCAAADYGTLKVDGQIAVVDGTGCSVVDKHNVAKQKGASA
Mb0426|M.bovis_AF2122/97 VAAPADD-SPGCSPSDYDRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVA
Rv0418|M.tuberculosis_H37Rv VAAPADD-SPGCSPSDYDRLPVSGAVVLVDRGVCPFAQKEDAAAQRGAVA
MUL_3587|M.ulcerans_Agy99 LLAPSDD-SPGCTPSDYDNLPVKGAVVLVDRGECQFAQKEDAAAQRGADA
TH_2315|M.thermoresistible__bu VPARADDDSPGCTADDYDGLPVDGAVVLVDRGHCPFGDKQAAAAERGAVA
: . **: ** : :** * . *. * .** .
Mflv_0189|M.gilvum_PYR-GCK VLVVSAATPSRPVGAPPTLFTPGYYNDLTVPVGVIDPTADAALRRTEAPV
Mvan_0716|M.vanbaalenii_PYR-1 MLVVSQASPSRPVGAAPTLFSPGYYHDLTVPVGVIDPAADAALRRTESPV
MSMEG_0807|M.smegmatis_MC2_155 LLVVSTSRPS-----PAGLFTSGYYGQLKVPVGVIDKTADAALRRTTRPV
MMAR_0727|M.marinum_M LIVISAAPDR---GSSANLFGPGYYNQLKVPVAVVGASGAAALARTNAPI
MAV_4737|M.avium_104 LIVVSAPDGH---GAPPTLFTPGYYKQLSVPVAVVNPSGAAALAGAGGPV
MAB_4212c|M.abscessus_ATCC_199 VLVAMQAGAG------EGLFTPNYYEQLSIPVGIIDSGVDTLLRRNSSPV
Mb0426|M.bovis_AF2122/97 LIIADNIDEQ------AMGGTLGANTDVKIPVVSVTKSVGFQLRGQSGPT
Rv0418|M.tuberculosis_H37Rv LIIADNIDEQ------AMGGTLGANTDVKIPVVSVTKSVGFQLRGQSGPT
MUL_3587|M.ulcerans_Agy99 LIIADNVDEQ------MMGGTLGVNTDVKIPVVSVTKSVGLQLRGKSGPA
TH_2315|M.thermoresistible__bu LIVANTVDEE------EMGGTLGERTEVEIPVVSVSKSEGARLRERPGPT
::: . :: :** : * *
Mflv_0189|M.gilvum_PYR-GCK TLVLDNKPVMTTSRNVIAQTRTGDPGNIVMVGAHLDSAASGPGINDNGSG
Mvan_0716|M.vanbaalenii_PYR-1 TLVLDNRPVMTTSRNVVAQTRTGDARNVVMVGAHLDSVRSGPGINDNGSG
MSMEG_0807|M.smegmatis_MC2_155 RLVLDNKAQMVKSRNLLAQTKTGSTDNVVVVGAHLDSIAGGPGINDNGSG
MMAR_0727|M.marinum_M RLVLDTENIQIKSRNVLAQTKTGTPDEVVMVGARLDSPPGSPGINSAGSG
MAV_4737|M.avium_104 RLILDAVNVKVTSRNVVAQTKTGSAHEVIMVGAHLDGSRAGPGINDNGSG
MAB_4212c|M.abscessus_ATCC_199 NLVLDMNVAKVRSHSVIAQTTTGDHANVVLTGAHLDSVSKGPGINDNGTG
Mb0426|M.bovis_AF2122/97 TVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVPEGPGINDNGSG
Rv0418|M.tuberculosis_H37Rv TVKLTASTQSFKARNVIAQTKTGSSANVVMAGAHLDSVPEGPGINDNGSG
MUL_3587|M.ulcerans_Agy99 TIKLTASSQSFKARNVIAQTKTGSTSDVVMAGAHLDSVPQGPGINDNGSG
TH_2315|M.thermoresistible__bu AITLEAGVETKRTRNVIAQTSTGATSDVVMIGAHLDGVPDGPGMNDNGSG
: * ::.::*** ** :::: **:**. .**:*. *:*
Mflv_0189|M.gilvum_PYR-GCK VAAVLETALQLGAQPQTANAVRFAFWGAEEISLDGSKAYLRSLERDQLND
Mvan_0716|M.vanbaalenii_PYR-1 VATVLETAVQLGGEPQTANAVRFTFWGAEEVSMDGSKTYLRSLSKEQLDD
MSMEG_0807|M.smegmatis_MC2_155 VSAILETALQLGGSPAINNAVRFAFWGAEETGLEGSSQYIRKLSPEQLDE
MMAR_0727|M.marinum_M VAAVLETALQLGPLPPVTNAVRFAFWG---DGINGAMDYVFGMDSEQLNS
MAV_4737|M.avium_104 VAAVLETALQLGPLAPVSNAVRFVFWGAGEDGLGGVMDYLFGLDRDQLND
MAB_4212c|M.abscessus_ATCC_199 VAAVLETALQLGPKPVVNNAVRFAFWTAEEDGLAGSLEYAKSRSPEELND
Mb0426|M.bovis_AF2122/97 VAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDALKG
Rv0418|M.tuberculosis_H37Rv VAAVLETAVQLGNSPHVSNAVRFAFWGAEEFGLIGSRNYVESLDIDALKG
MUL_3587|M.ulcerans_Agy99 VAAVLETAVQLGNSPHVHNAVRVAFWGAEELGLIGSRNYVQSLDLDELKN
TH_2315|M.thermoresistible__bu VAAVLETARQLGSAPDIANAVRFGFWGAEEVGLRGSRAYLASLDVEELKD
*:::**** *** . ****. ** .: * * . : *.
Mflv_0189|M.gilvum_PYR-GCK IALYLNFDMLGSINAGYFTDDGDQS---TQMEPDFVVAPEGSAGIERTLA
Mvan_0716|M.vanbaalenii_PYR-1 IALYLNFDMVGSPNPGYFTDDGDQS---TQTGP-VAPVPDGSAGIERTLA
MSMEG_0807|M.smegmatis_MC2_155 LALYLNFDMLGSTNTGYFTYDGDQS---AQAGD-PKPVPEGSAGVERTLA
MMAR_0727|M.marinum_M IALYLNFDMLGSPNAGYFTDDGDQSGL-PGTGVRSADVPEGSAAIERTLA
MAV_4737|M.avium_104 IALYLNFTMLGSPNAGFFTDDGDQSGP-PAPGISAADVPEGSAGIERTLA
MAB_4212c|M.abscessus_ATCC_199 IALYLNFDMLGSPNAGYFVLDGDQSAAKPDPNRPPLDVPEGSAGIERTFA
Mb0426|M.bovis_AF2122/97 IALYLNFDMLASPNPGYFTYDGDQSLP-LDARG-QPVVPEGSAGIERTFV
Rv0418|M.tuberculosis_H37Rv IALYLNFDMLASPNPGYFTYDGDQSLP-LDARG-QPVVPEGSAGIERTFV
MUL_3587|M.ulcerans_Agy99 IALYLNFDMLASPNPGIFTYDGDQSLP-LVEHG-QPVVPEGSAGIERTLV
TH_2315|M.thermoresistible__bu IAVYLNLDMVGSPNPGYFTYDGDLSSP-PDPNRPAPRVPEGSAGVERTLV
:*:***: *:.* *.* *. *** * .*:***.:***:.
Mflv_0189|M.gilvum_PYR-GCK GSLLLAGVRPADIPLTRTTDYAPFLAAGIPVGGLTTGSSQRKTEVQGRLW
Mvan_0716|M.vanbaalenii_PYR-1 ARLNTAGVRPADMPLTRTTDYGPFLAAGIPVGGLTTGSSQLKTEVQARLW
MSMEG_0807|M.smegmatis_MC2_155 GFLNLQGVRPADMPLSANTDYSAFMNAGVPIGGATTGSSQRKTEVQARLW
MMAR_0727|M.marinum_M GYLNLAGKRPADMPLSIRSDYHPFLVAGVPIGGMTTGASQTKTTVQARLW
MAV_4737|M.avium_104 GYLNLAGKRAADMPLNTRADYHPFMVAGVPIGGMTTGASQPKTTVQSRLW
MAB_4212c|M.abscessus_ATCC_199 GYLNLAGKRPAAEEFSGRSDYGPFMAAGIPVGGISSGALERMSGPEAKTW
Mb0426|M.bovis_AF2122/97 AYLKMAGKTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELW
Rv0418|M.tuberculosis_H37Rv AYLKMAGKTAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKKSAEQAELW
MUL_3587|M.ulcerans_Agy99 SYLRLSGKIAQDTSFDGRSDYDGFTLAGIPSGGLFSGAEVKMTEEQAKLW
TH_2315|M.thermoresistible__bu AALADEDIEPDDVNLEGRSDNDSFTLAGIPAGGLFTGGSGEKTEEQAERW
. * . . : :* * **:* ** :*. : :.. *
Mflv_0189|M.gilvum_PYR-GCK GGEAGVPFDPNYHTRRDDIDNVDRTALGRMASSAAFAVGTYADALDGVNG
Mvan_0716|M.vanbaalenii_PYR-1 GGQAGVAFDPNYHTPRDDIDNVDRGALAIMASSAAFAIGTYAQSIDGVNG
MSMEG_0807|M.smegmatis_MC2_155 GGKSGVAFDPNYHTRRDNIDNVDAHALSVMGPAVAFAVGTYALSTDGPNG
MMAR_0727|M.marinum_M GGQAGVAFDPEYLSVGDTIDNINRQALEVMGSGVAFAVGAYAESIRGVNG
MAV_4737|M.avium_104 GGQAGVPFDPDFQGPRDTADNINRDALAVMGSGVGFAVGSYAQSIGGVNG
MAB_4212c|M.abscessus_ATCC_199 EGHAGQPFDPNYHGPKDTLANVGKTALGINGPAVAFAVGTYALSTTGPNG
Mb0426|M.bovis_AF2122/97 GGTADEPFDPNYHQKTDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNG
Rv0418|M.tuberculosis_H37Rv GGTADEPFDPNYHQKTDTLDHIDRTALGINGAGVAYAVGLYAQDLGGPNG
MUL_3587|M.ulcerans_Agy99 GGTADEPFDPNYHQKSDTIDHIDRTSLGIQGGGVAYAVGLYAQDLTGRNG
TH_2315|M.thermoresistible__bu GGTAGEPFDPNYHKEGDDLDNIDRTALAVNAAAAAYAVGMYAQDQRGRNG
* :. .***:: * ::. :* . ...:*:* ** * **
Mflv_0189|M.gilvum_PYR-GCK VPERDRRDRRTP---
Mvan_0716|M.vanbaalenii_PYR-1 VPARDERDRSAP---
MSMEG_0807|M.smegmatis_MC2_155 VPGRDQRKRS-----
MMAR_0727|M.marinum_M VTPHDKRHRARVS--
MAV_4737|M.avium_104 VPPHDKRHRTRVP--
MAB_4212c|M.abscessus_ATCC_199 VPERKLRRHSPLER-
Mb0426|M.bovis_AF2122/97 VPVMADRTRHLIAKP
Rv0418|M.tuberculosis_H37Rv VPVMADRTRHLIAKP
MUL_3587|M.ulcerans_Agy99 VPVIGDRTRHVLAKP
TH_2315|M.thermoresistible__bu LPIRDDRTRHQLSNP
:. * :