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IRIGTRGSLLATTQAGTIRDALIAAGHDAELVIISTEGDRRADEPIADIGVGVFTAALREAIADNVVDAA VHSYKDLPTAVDPRFMIAATPVREDARDALVARDGMVLGELPAGSVIGTSSPRRVAQLKALGLGLEIRPL RGNLDTRLNRVSSGELDAIVVAKAGLSRIGRLEVVTETLEPVQMLPAPAQGALAIECRAGDTALAQLLAE LDDADTRAAVTAERTLLAELEAGCSAPVGAIAEVVESIDEDGRVFEELSLRGCVATLDGSDVIRASGIGS PDRARELGLSVAAELFDLGARDLLDERGRDT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0066 | hemC | - | 100% (312) | porphobilinogen deaminase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0523 | hemC | 1e-137 | 82.62% (305) | porphobilinogen deaminase |
| M. tuberculosis H37Rv | Rv0510 | hemC | 1e-137 | 82.62% (305) | porphobilinogen deaminase |
| M. leprae Br4923 | MLBr_02421 | hemC | 1e-128 | 77.05% (305) | porphobilinogen deaminase |
| M. abscessus ATCC 19977 | MAB_3992c | hemC | 1e-134 | 80.66% (305) | porphobilinogen deaminase |
| M. marinum M | MMAR_0843 | hemC | 1e-136 | 82.95% (305) | porphobilinogen deaminase HemC |
| M. avium 104 | MAV_4639 | hemC | 1e-137 | 81.03% (311) | porphobilinogen deaminase |
| M. smegmatis MC2 155 | MSMEG_0953 | hemC | 1e-144 | 85.21% (311) | porphobilinogen deaminase |
| M. thermoresistible (build 8) | TH_0268 | hemC | 1e-140 | 83.44% (308) | PROBABLE PORPHOBILINOGEN DEAMINASE HEMC (PBG) |
| M. ulcerans Agy99 | MUL_4599 | hemC | 1e-135 | 82.30% (305) | porphobilinogen deaminase |
| M. vanbaalenii PYR-1 | Mvan_0845 | hemC | 1e-158 | 91.64% (311) | porphobilinogen deaminase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0523|M.bovis_AF2122/97 -------MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGD-RS
Rv0510|M.tuberculosis_H37Rv -------MIRIGTRGSLLATTQAATVRDALIAGGHSAELVTISTEGD-RS
MMAR_0843|M.marinum_M -------MIRIGTRGSLLATTQAATVRDALIANGHAAELVTISTLGD-RS
MUL_4599|M.ulcerans_Agy99 -------MIRIGTRGSLLATTQAAIVRDALIANGHAAELVTISTLGD-RS
MAV_4639|M.avium_104 -------MIRIGTRGSLLATTQAGGVRDALIARGHPAELVTITTAGD-RS
MLBr_02421|M.leprae_Br4923 ----MAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGD-QS
Mflv_0066|M.gilvum_PYR-GCK -------MIRIGTRGSLLATTQAGTIRDALIAAGHDAELVIISTEGDRRA
Mvan_0845|M.vanbaalenii_PYR-1 -------MIRIGTRGSLLATTQAGTVRDALIAAGHDAELVIVSTEGDQRA
MSMEG_0953|M.smegmatis_MC2_155 MANNRDSVIRLGTRGSLLATTQAGTVRDALLAAGHPCELVIISTEGD-RN
TH_0268|M.thermoresistible__bu -LTQRDGVIRIGTRGSLLATTQAGVIRDALISRGHPAELVIISTRGDRSP
MAB_3992c|M.abscessus_ATCC_199 -------MIRIGTRGSLLATTQAGGIRDALRAKGHEAELVIVTTAGD-QS
:**:************. :**** : ** .*** :.* **
Mb0523|M.bovis_AF2122/97 MAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPP
Rv0510|M.tuberculosis_H37Rv MAPIASLGVGVFTTALREAMEAGLVDAAVHSYKDLPTAADPRFTVAAIPP
MMAR_0843|M.marinum_M SAPIETLGVGVFTTALREAIEDGRVDAAVHSHKDLPTAQDPRFTIAAIPP
MUL_4599|M.ulcerans_Agy99 SAPIETLGVGVFTTALREAIEDGRVDAAVHSHKDLPTAQDPRFTIAAIPP
MAV_4639|M.avium_104 SGPIESLGVGVFTTALREAIEEGRVDAAVHSHKDLPTADDPRFAVAAIPA
MLBr_02421|M.leprae_Br4923 SASIDSLGVGVFTTALRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPP
Mflv_0066|M.gilvum_PYR-GCK DEPIADIGVGVFTAALREAIADNVVDAAVHSYKDLPTAVDPRFMIAATPV
Mvan_0845|M.vanbaalenii_PYR-1 DAPIAEIGVGVFTAALREAIADGLVDAAVHSYKDLPTAPDPRFMIAATPV
MSMEG_0953|M.smegmatis_MC2_155 QGPIADIGIGVFTAALREAIHDGRVDMAVHSYKDLPTASDERFCIPAIPR
TH_0268|M.thermoresistible__bu DTPIEHMGVGVFTAELREAILDGRVDAAVHSYKDLPTADDPRFAIPAVPP
MAB_3992c|M.abscessus_ATCC_199 AAPVEQIGVGVFTAALREAIADDVVDVAVHSYKDLPTAADPRFVIPAIPP
.: :*:****: ** *: . ** ****:****** * ** :.* *
Mb0523|M.bovis_AF2122/97 RNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRG
Rv0510|M.tuberculosis_H37Rv RNDPRDAVVARDGLTLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRG
MMAR_0843|M.marinum_M RQDPRDAVVARDGLVLGELPVGSLVGTSSPRRAAQLRALGLGLEIRPLRG
MUL_4599|M.ulcerans_Agy99 RQDPRDAVVARDGLVLGELPVGSLVGTSSPRRAAQFRALGLGLEIRPLRG
MAV_4639|M.avium_104 RNDPRDAVVARDGLVLGELPPGSLVGTSSPRRAAQLRALGLGLEIRPLRG
MLBr_02421|M.leprae_Br4923 RNDPRDAVVTRDELVLAELPAGSLVGTSSPRRAAQLRALGLGLEIRPLRG
Mflv_0066|M.gilvum_PYR-GCK REDARDALVARDGMVLGELPAGSVIGTSSPRRVAQLKALGLGLEIRPLRG
Mvan_0845|M.vanbaalenii_PYR-1 REDARDALVARDGLVLGELPAGSVIGTSSPRRAAQLRALGLGLEIRPLRG
MSMEG_0953|M.smegmatis_MC2_155 REDPRDALVARDGLVLGELPTGSVIGTSSPRRAAQLRALGLGLEIRPLRG
TH_0268|M.thermoresistible__bu REDPRDVLVARDNLVLGELPAGSLIGTSSPRRAAQLRALGLGLEIRPLRG
MAB_3992c|M.abscessus_ATCC_199 REDYRDALVARDGLVLGELPAGSVIGTSSPRRAAQLRALGLGLEIRPLRG
*:* **.:*:** :.*.*** **::*******.**::*************
Mb0523|M.bovis_AF2122/97 NLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGA
Rv0510|M.tuberculosis_H37Rv NLDTRLNKVSSGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGA
MMAR_0843|M.marinum_M NLDTRLNRVSNGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGA
MUL_4599|M.ulcerans_Agy99 NLDTRLNRVSNGDLDAIVVARAGLARLGRLDDVTETLEPVQMLPAPAQGA
MAV_4639|M.avium_104 NLDTRLNRVSSGDLDAIVVARAGLARLGRLGDVTETLEPVQMLPAPAQGA
MLBr_02421|M.leprae_Br4923 NLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTETLDPVQMVPAPAQGA
Mflv_0066|M.gilvum_PYR-GCK NLDTRLNRVSSGELDAIVVAKAGLSRIGRLEVVTETLEPVQMLPAPAQGA
Mvan_0845|M.vanbaalenii_PYR-1 NLDTRLNRVSSGELDAIVVARAGLARIGRLDAVTEALEPVQMLPAPAQGA
MSMEG_0953|M.smegmatis_MC2_155 NLDTRLNRVTSGELDGIVVARAGLARIGRLNVVTETLEPVQMLPAPAQGA
TH_0268|M.thermoresistible__bu NLDTRLNRVRNGELDGIVVARAGLARIGRLEVVTETLEPVQMLPAPAQGA
MAB_3992c|M.abscessus_ATCC_199 NLDTRLSRVSNGDLDGVVVARAGLARIGRLDHITETLEPVQVLPAPAQGA
******.:* .*:**.:***:***:*:*** :**:*:***::*******
Mb0523|M.bovis_AF2122/97 LAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIA
Rv0510|M.tuberculosis_H37Rv LAVECRAGDSRLVAVLAELDDADTRAAVTAERALLADLEAGCSAPVGAIA
MMAR_0843|M.marinum_M LAIECRAGDSRLATVLAELDDADTRAAVTAERALLAELEAGCSAPVGAIA
MUL_4599|M.ulcerans_Agy99 LAIECRAGDSRLATVLAELDDADTRAAVTAERALLAELEAGCSAPVGAIA
MAV_4639|M.avium_104 LAVECRAGDSRLAAVLAELDDADTRASVTAERALLAELEAGCSAPVGAIA
MLBr_02421|M.leprae_Br4923 IAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAPVGAIA
Mflv_0066|M.gilvum_PYR-GCK LAIECRAGDTALAQLLAELDDADTRAAVTAERTLLAELEAGCSAPVGAIA
Mvan_0845|M.vanbaalenii_PYR-1 LAVECRAGDTALAQVLSQLDDADTRAAITAERTLLAELEAGCSAPVGAIA
MSMEG_0953|M.smegmatis_MC2_155 LAVECRAGDTELIAILSELDDADTRAAVTAERVLLAELEAGCSAPVGAIA
TH_0268|M.thermoresistible__bu LAVECRAEDTGLAAILAELDDSDTRAAVTAERVLLAELEAGCSAPVGAIA
MAB_3992c|M.abscessus_ATCC_199 LAVECRSEATDLVAVLAELDHADTRAAVTAERALLAELEAGCTAPVGAIA
:*:***: : * :*: **.:****::****.***:*****:*******
Mb0523|M.bovis_AF2122/97 EVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVA
Rv0510|M.tuberculosis_H37Rv EVVESIDEDGRVFEELSLRGCVAALDGSDVIRASGIGSCGRARELGLSVA
MMAR_0843|M.marinum_M EVVESIDEEGRVFEELSLRGCVAALDGSDVIRASGIGTSGRARELGLAVA
MUL_4599|M.ulcerans_Agy99 EVVESIDEEGRVFEELSLRGCVAALDGSDVIRASGIGTSGRARELGLAVA
MAV_4639|M.avium_104 EVVESIDEDGRIFEELSLRGCVAALDGSDVIRASGIGTPGRARELGLSVA
MLBr_02421|M.leprae_Br4923 QVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVA
Mflv_0066|M.gilvum_PYR-GCK EVVESIDEDGRVFEELSLRGCVATLDGSDVIRASGIGSPDRARELGLSVA
Mvan_0845|M.vanbaalenii_PYR-1 EVVESIDEDGRVFEELSLRGCVATLDGSDVIRATGIGTPDRARELGLSVA
MSMEG_0953|M.smegmatis_MC2_155 EVVESIDEDGNVFEELSLRGCAATLDGSDVIRASGIGTPDRAAELGVSVA
TH_0268|M.thermoresistible__bu EVVESIDEDGRVFEELSLRACVATVSGSDVIRASGVGTPGRARELGVSVA
MAB_3992c|M.abscessus_ATCC_199 EVVESIDEEGRVFDELSLRGCAAALDGSDVIRASGIGTPDRAAELGLAVA
:****** :*.:*:*****.*.*::.*******:*:.: .** ***::**
Mb0523|M.bovis_AF2122/97 AELFELGARELMWGVRH------
Rv0510|M.tuberculosis_H37Rv AELFELGARELMWGVRH------
MMAR_0843|M.marinum_M AELFELGARELMWGEGNSPQGS-
MUL_4599|M.ulcerans_Agy99 AELFELGARELMWGEGNSPQGS-
MAV_4639|M.avium_104 AELFELGARELMSGARHDPARGN
MLBr_02421|M.leprae_Br4923 VELFELGARELMWGARSDRARGS
Mflv_0066|M.gilvum_PYR-GCK AELFDLGARDLLDERGRDT----
Mvan_0845|M.vanbaalenii_PYR-1 EELFELGARDLLDEGGRDR----
MSMEG_0953|M.smegmatis_MC2_155 AELFDLGARELLEERGSEK----
TH_0268|M.thermoresistible__bu AELFELGARELMADRTEL-----
MAB_3992c|M.abscessus_ATCC_199 RELLDLGARALIGR---------
**::**** *: