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VAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSPPAKRATKPAARSVKPASAPQDTTTS TIPKRKTRAAAKSAAAKAPSARGHATKPRAPKDAQHEAATDPEDALDSVEELDAEPDLDVEPGEDLDLDA ADLNLDDLEDDVAPDADDDLDSGDDEDHEDLEAEAAVAPGQTADDDEEIAEPTEKDKASGDFVWDEDESE ALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRD MMWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWW IRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREP ISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLD EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2722 | sigA | - | 100% (528) | RNA polymerase sigma factor |
| M. bovis AF2122 / 97 | Mb2729 | sigB | e-106 | 62.86% (315) | RNA polymerase sigma factor SigB |
| M. bovis AF2122 / 97 | Mb3314c | sigF | 2e-18 | 27.95% (229) | RNA polymerase sigma factor SigF |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3939 | - | 0.0 | 75.05% (529) | RNA polymerase sigma factor |
| M. tuberculosis H37Rv | Rv2703 | sigA | 0.0 | 100.00% (528) | RNA polymerase sigma factor |
| M. leprae Br4923 | MLBr_01022 | rpoT | 0.0 | 80.68% (533) | RNA polymerase sigma factor |
| M. abscessus ATCC 19977 | MAB_3009 | - | 0.0 | 75.59% (512) | RNA polymerase sigma factor |
| M. marinum M | MMAR_2011 | sigA | 0.0 | 80.72% (529) | RNA polymerase sigma factor SigA |
| M. avium 104 | MAV_3595 | - | 0.0 | 82.66% (519) | RNA polymerase sigma factor |
| M. smegmatis MC2 155 | MSMEG_2758 | - | 0.0 | 75.76% (528) | RNA polymerase sigma factor |
| M. thermoresistible (build 8) | TH_0829 | sigB | 1e-146 | 85.49% (317) | RNA POLYMERASE SIGMA FACTOR SIGB |
| M. ulcerans Agy99 | MUL_3341 | sigA | 0.0 | 80.91% (529) | RNA polymerase sigma factor |
| M. vanbaalenii PYR-1 | Mvan_2461 | - | 0.0 | 76.32% (532) | RNA polymerase sigma factor |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2722|M.bovis_AF2122/97 --------------------------------------------------
Rv2703|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_2011|M.marinum_M --------------------------------------------------
MUL_3341|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01022|M.leprae_Br4923 MEQSRRVPPLQWLSAVARPIARVLTLISTPTFDIADTFGYACPNPPEVSP
MAV_3595|M.avium_104 --------------------------------------------------
TH_0829|M.thermoresistible__bu --------------------------------------------------
Mflv_3939|M.gilvum_PYR-GCK ------------------------------------------MCAPTTRT
Mvan_2461|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2758|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3009|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2722|M.bovis_AF2122/97 -----MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSP
Rv2703|M.tuberculosis_H37Rv -----MAATKASTATDEPVKRTATKSPAASASGAKTGAKRTAAKSASGSP
MMAR_2011|M.marinum_M -----MAATKASPETGEPVKRTATKSP------AKAGAKR-PTKTANGAA
MUL_3341|M.ulcerans_Agy99 -----MAATKASPETGEPVKRTATKSP------AKAGAKR-PTKTANGAP
MLBr_01022|M.leprae_Br4923 TEGVYVVATKTSPATGQPVKRTATKTP-------ATPAKRSTTKAANGSA
MAV_3595|M.avium_104 ------------------MKRTATKSP-------SSPAKRPAAKAANGSA
TH_0829|M.thermoresistible__bu --------------------------------------------------
Mflv_3939|M.gilvum_PYR-GCK TERVYVAATKASAATDEPVKRTAAKAP-------------------AKKA
Mvan_2461|M.vanbaalenii_PYR-1 -----MAATKASPATEEPVKRTAAKAP-------------------AKKA
MSMEG_2758|M.smegmatis_MC2_155 -----MAATKASPATEEPVKRTATKTP-------------------AKKA
MAB_3009|M.abscessus_ATCC_1997 -----MAATKAAPVTQATAETPSNTTA-------------------TKAA
Mb2722|M.bovis_AF2122/97 PAKRATKPAARSVKPASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHA
Rv2703|M.tuberculosis_H37Rv PAKRATKPAARSVKPASAPQDTTTSTIPKRKTRAAAKSAAAKAPSARGHA
MMAR_2011|M.marinum_M PAKRAAKTTG-------QADDATTGDAPK-KTR----------PSARG--
MUL_3341|M.ulcerans_Agy99 PAKRAAKTPG-------QADDATTGDAPK-KTR----------PSARG--
MLBr_01022|M.leprae_Br4923 PTKRATSTASRATKSTTPPKASGASDAAK-KARTSVKSVDTKAPSAQDHT
MAV_3595|M.avium_104 PAKRATKTASRSAKS----EAGAAAEPAK-KTRSSAKGADAKAPSGRG--
TH_0829|M.thermoresistible__bu --------------------------------------------------
Mflv_3939|M.gilvum_PYR-GCK PAKKATK-----------ATKPRAAKSAD-------------APATRGRA
Mvan_2461|M.vanbaalenii_PYR-1 PAKKAAKSAPA------KATKPRAAKSAD-------------APATRGRA
MSMEG_2758|M.smegmatis_MC2_155 PAKRAAK-------------SAAAKAGGK-------------APAKKAPA
MAB_3009|M.abscessus_ATCC_1997 PAKKAPA------------KAATKAPAKK-------------APAKKAPA
Mb2722|M.bovis_AF2122/97 TKPRAPKDAQHEA--ATDPEDALDSVEELDAEPDLDVEPGEDLDLD--AA
Rv2703|M.tuberculosis_H37Rv TKPRAPKDAQHEA--ATDPEDALDSVEELDAEPDLDVEPGEDLDLD--AA
MMAR_2011|M.marinum_M TKAARGTKAPGEG--ATDPDANLDTADDLDADPDIDVDSSDDLDLD--LD
MUL_3341|M.ulcerans_Agy99 TKAARGTKAPGEG--ATDPDANLDTADDLDADPDIDVDSSDDLDLD--LD
MLBr_01022|M.leprae_Br4923 TKASAAKDTLNDPEATLNTLDSDATADDLDAEPDLDVEPSEDIDIDIEAA
MAV_3595|M.avium_104 --TKAAKGGPADP----DALDTDGAVEDLDTEPDLEGEPGEDLDID---T
TH_0829|M.thermoresistible__bu ----------------------MANATTSRVDSDLDAQS-----------
Mflv_3939|M.gilvum_PYR-GCK KKATAAEPGVVDD--------ELTGTEVDATDD---IEPGEDL---VDDG
Mvan_2461|M.vanbaalenii_PYR-1 KKATA--PGAVDD--------DLAGSDVETGDDLVEAEPGDDLE--VEDT
MSMEG_2758|M.smegmatis_MC2_155 KRAAKGTAAKPED--------GVT-DDLEVTDD-LEAEPGEDLD--VEDT
MAB_3009|M.abscessus_ATCC_1997 KAATKAPAKKAPA--------KKAPAKKAAAKA---TDPALEPQGAADDA
. :.
Mb2722|M.bovis_AF2122/97 DLNLDDLEDDVAPDADDDLDSGDDEDHED-LEAEAAVAPGQTADDDEEIA
Rv2703|M.tuberculosis_H37Rv DLNLDDLEDDVAPDADDDLDSGDDEDHED-LEAEAAVAPGQTADDDEEIA
MMAR_2011|M.marinum_M DLEDEDEAASDEAEGDDDSDEGDDAEDGDGAKAPAAAAPG-TPSDEEEIA
MUL_3341|M.ulcerans_Agy99 DLEDEDEAASDEAEGDDDSDEGDDAEYGDGAKAPAAAAPG-TASDEEEIA
MLBr_01022|M.leprae_Br4923 DLGLDDLEDDDVVT---DIEPGETEDGE---ATAATKTDEASTDDDEEIV
MAV_3595|M.avium_104 DLNLDDLEEDVAADDA-DIEPGDAEEGEDEEAAAPKAAGATAADEDDEIA
TH_0829|M.thermoresistible__bu --------------------------------------------------
Mflv_3939|M.gilvum_PYR-GCK DLELDD-IEVEDEATEDDDSDDEAAEADPVVATTKAAAKPAKEADDDSLP
Mvan_2461|M.vanbaalenii_PYR-1 DLVLDEELEVDDDTAVDGDSDDEDADEG-----APKAAKPAKDGDDDGVA
MSMEG_2758|M.smegmatis_MC2_155 DLELDD-LDSDDDTAVEDEEEEADAATP--------AVATAKAADDD-ID
MAB_3009|M.abscessus_ATCC_1997 DIEPGD--DLDTDLADDADIEADLAEAA---------AEPEPEAEADGDD
Mb2722|M.bovis_AF2122/97 EPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVAL
Rv2703|M.tuberculosis_H37Rv EPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVAL
MMAR_2011|M.marinum_M EPSEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVAL
MUL_3341|M.ulcerans_Agy99 EPSEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVAL
MLBr_01022|M.leprae_Br4923 EPTEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVAL
MAV_3595|M.avium_104 EPSEKDKASGDFVWDEDESEALRQARKDAELTASADSVRAYLKQIGKVAL
TH_0829|M.thermoresistible__bu --------------------------------PAADLVRVYLNGIGKTAL
Mflv_3939|M.gilvum_PYR-GCK EPSEKDKASGDFVWDEEESEALRQARKDAELTASADSVRAYLKQIGKVAL
Mvan_2461|M.vanbaalenii_PYR-1 EPSEKDKASGDFVWDEEESEALRQARKDAELTASADSVRAYLKQIGKVAL
MSMEG_2758|M.smegmatis_MC2_155 EPSEKDKASGDFVWDEEESEALRQARKDAELTASADSVRAYLKQIGKVAL
MAB_3009|M.abscessus_ATCC_1997 EPSEKDKASGDFVWDEEESEALRQARKDAELTASADSVRAYLKQIGKVAL
.:** **.**: ***.**
Mb2722|M.bovis_AF2122/97 LNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDR
Rv2703|M.tuberculosis_H37Rv LNAEEEVELAKRIEAGLYATQLMTELSERGEKLPAAQRRDMMWICRDGDR
MMAR_2011|M.marinum_M LNAEEEVELAKRIEAGLYATQLMAELTDRGEKLPAAQRRDMMWICRDGDR
MUL_3341|M.ulcerans_Agy99 LNAEEEVELAKRIEAGLYATQLMAELTDRGEKLPAAQRRDMMWICRDGDR
MLBr_01022|M.leprae_Br4923 LNAEEEVELAKRIEAGLYATQLMTELSERGTKLPTAQRRDMMWICRDGDR
MAV_3595|M.avium_104 LNAEEEVELAKRIEAGLYATQLMSEMAERGEKLPAAQRRDMMWICRDGDR
TH_0829|M.thermoresistible__bu LDAAEEVELAKRIEAGLYAQHLLKTKKRLGQ----NRKRDLEAIVRDGEE
Mflv_3939|M.gilvum_PYR-GCK LNAEEEVELAKRIEAGLYCTQLMAEFAEKGEKLTTAQRRDYMWICRDGDR
Mvan_2461|M.vanbaalenii_PYR-1 LNAEEEVELAKRIEAGLYATQLMAELADKGEKLPAAQRRDMMWICRDGDR
MSMEG_2758|M.smegmatis_MC2_155 LNAEEEVELAKRIEAGLYATQKLAELAEKGEKLPVQQRRDMQWICRDGDR
MAB_3009|M.abscessus_ATCC_1997 LNAEEEVELAKRIEAGLYATQIVTELTEKGEKLPAAQRRDMMWICRDGDR
*:* **************. : : * ::** * ***:.
Mb2722|M.bovis_AF2122/97 AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
Rv2703|M.tuberculosis_H37Rv AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
MMAR_2011|M.marinum_M AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
MUL_3341|M.ulcerans_Agy99 AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
MLBr_01022|M.leprae_Br4923 AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
MAV_3595|M.avium_104 AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
TH_0829|M.thermoresistible__bu ARRHLLEANLRLVVSLAKRYTGRGMPLLDLIQEGNLGLIRAMEKFDYTKG
Mflv_3939|M.gilvum_PYR-GCK AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
Mvan_2461|M.vanbaalenii_PYR-1 AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
MSMEG_2758|M.smegmatis_MC2_155 AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
MAB_3009|M.abscessus_ATCC_1997 AKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKG
*:.**********************.:**************:********
Mb2722|M.bovis_AF2122/97 YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
Rv2703|M.tuberculosis_H37Rv YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
MMAR_2011|M.marinum_M YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
MUL_3341|M.ulcerans_Agy99 YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
MLBr_01022|M.leprae_Br4923 YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
MAV_3595|M.avium_104 YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
TH_0829|M.thermoresistible__bu FKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
Mflv_3939|M.gilvum_PYR-GCK YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
Mvan_2461|M.vanbaalenii_PYR-1 YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
MSMEG_2758|M.smegmatis_MC2_155 YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
MAB_3009|M.abscessus_ATCC_1997 YKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVINKLGRIQRELLQDL
:*************************************************
Mb2722|M.bovis_AF2122/97 GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
Rv2703|M.tuberculosis_H37Rv GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
MMAR_2011|M.marinum_M GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
MUL_3341|M.ulcerans_Agy99 GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
MLBr_01022|M.leprae_Br4923 GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
MAV_3595|M.avium_104 GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
TH_0829|M.thermoresistible__bu GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
Mflv_3939|M.gilvum_PYR-GCK GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
Mvan_2461|M.vanbaalenii_PYR-1 GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
MSMEG_2758|M.smegmatis_MC2_155 GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
MAB_3009|M.abscessus_ATCC_1997 GREPTPEELAKEMDITPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIE
**************************************************
Mb2722|M.bovis_AF2122/97 DSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLD
Rv2703|M.tuberculosis_H37Rv DSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLD
MMAR_2011|M.marinum_M DSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLD
MUL_3341|M.ulcerans_Agy99 DSEAVVAVDAVSFTLLQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLD
MLBr_01022|M.leprae_Br4923 DSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLD
MAV_3595|M.avium_104 DSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLD
TH_0829|M.thermoresistible__bu DSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLD
Mflv_3939|M.gilvum_PYR-GCK DSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLD
Mvan_2461|M.vanbaalenii_PYR-1 DSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLD
MSMEG_2758|M.smegmatis_MC2_155 DSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLD
MAB_3009|M.abscessus_ATCC_1997 DSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGVVRLRFGLTDGQPRTLD
************************:*************************
Mb2722|M.bovis_AF2122/97 EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
Rv2703|M.tuberculosis_H37Rv EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
MMAR_2011|M.marinum_M EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
MUL_3341|M.ulcerans_Agy99 EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
MLBr_01022|M.leprae_Br4923 EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
MAV_3595|M.avium_104 EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
TH_0829|M.thermoresistible__bu EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
Mflv_3939|M.gilvum_PYR-GCK EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
Mvan_2461|M.vanbaalenii_PYR-1 EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
MSMEG_2758|M.smegmatis_MC2_155 EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
MAB_3009|M.abscessus_ATCC_1997 EIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD
**************************************