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VTVVVVTDTSCRLPADLREQWSIRQVPLHILLDGLDLRDGVDEIPDDIHKRHATTAGATPVELSAAYQRA LADSGGDGVVAVHISSALSGTFRAAELTAAELGPAVRVIDSRSAAMGVGFAALAAGRAAAAGDELDTVAR AAAAAVSRIHAFVAVARLDNLRRSGRISGAKAWLGTALALKPLLSVDDGKLVLVQRVRTVSNATAVMIDR VCQLVGDRPAALAVHHVADPAAANDVAAALAERLPACEPAMVTAMGPVLALHVGAGAVGVCVDVGASPPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2440c | - | - | 100% (280) | hypothetical protein Mb2440c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2657 | - | 2e-89 | 61.59% (276) | degV family protein |
| M. tuberculosis H37Rv | Rv2417c | - | 1e-154 | 100.00% (280) | hypothetical protein Rv2417c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1625 | - | 1e-74 | 53.85% (273) | hypothetical protein MAB_1625 |
| M. marinum M | MMAR_3745 | - | 1e-116 | 75.09% (277) | hypothetical protein MMAR_3745 |
| M. avium 104 | MAV_1754 | - | 1e-110 | 75.37% (272) | DegV family protein |
| M. smegmatis MC2 155 | MSMEG_4577 | - | 9e-87 | 61.59% (276) | DegV family protein |
| M. thermoresistible (build 8) | TH_0785 | - | 6e-48 | 70.68% (133) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3689 | - | 1e-115 | 74.73% (277) | hypothetical protein MUL_3689 |
| M. vanbaalenii PYR-1 | Mvan_3922 | - | 2e-87 | 60.58% (274) | degV family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2440c|M.bovis_AF2122/97 MTVVVVTDTSCRLPADLREQWSIRQVPLHILLDGLDLRDGVDEIPDDIH-
Rv2417c|M.tuberculosis_H37Rv MTVVVVTDTSCRLPADLREQWSIRQVPLHILLDGLDLRDGVDEIPDDIH-
MMAR_3745|M.marinum_M MAVVVVTDTSARLPADIRERWAIREVPLHILLDGVDLRDGVDEVPDDIH-
MUL_3689|M.ulcerans_Agy99 MAVVVVTDTSARLPVDIRERWAIREVALHILLDGVDLRDGVDEVPDDIH-
MAV_1754|M.avium_104 MAVVVVTDSSARLPADLLGQWGIRVVPLHILLDGTDLRDGVDEVPADIH-
MAB_1625|M.abscessus_ATCC_1997 MPVVVVTDSGARLQPQDAEMLGIRLVPLHVLTGEQDLRDGVDPIPAAVYE
Mflv_2657|M.gilvum_PYR-GCK MPVVVVSDSSSRLQPEQRRRWGIREVPLHVLVDGVDLRDGVDDIPYDIHD
Mvan_3922|M.vanbaalenii_PYR-1 MPVVVVSDSSSRLQPEVRAQWDIREVPLHVLVDGVDLRDGIDDIPYDIHD
MSMEG_4577|M.smegmatis_MC2_155 MAVVVVTDSSSRLSRQLCERWGIRQVPLHILDGDNDLRDGVDAVPSDIHD
TH_0785|M.thermoresistible__bu VAVVVVTDSSARLSAEVRSRWAIRQVPLHVLVDGTDLRDGIDPVPHDIHN
:.****:*:..** : ** *.**:* . *****:* :* ::
Mb2440c|M.bovis_AF2122/97 KRHATTAGATPVELSAAYQRALADSGGDGVVAVHISSALSGTFRAAELTA
Rv2417c|M.tuberculosis_H37Rv KRHATTAGATPVELSAAYQRALADSGGDGVVAVHISSALSGTFRAAELTA
MMAR_3745|M.marinum_M KCHATTAAATPAELRAAYRAALADSAGDGVVAVHISAGLSGTYRAAKLAA
MUL_3689|M.ulcerans_Agy99 KCHATTAAATPVELRAAYRAALADSAGDGVVAVHISAGLSGTYRAAKLAA
MAV_1754|M.avium_104 QRAATTAAATPAELADAYQQALADSGGDGVVAVHISSALSGTCRAAERTA
MAB_1625|M.abscessus_ATCC_1997 KGRATTAGASPAELTEVYRQALIDSGGDGVVAVHLSGRLSSTFEAAEQAA
Mflv_2657|M.gilvum_PYR-GCK RPKVTTAGASPAELSEVYRQALADSGGDGVVAVHLSGALSSTYSAAATVA
Mvan_3922|M.vanbaalenii_PYR-1 RPKVTTAGATPAELVETYRQALADSDGAGVVAVHLSAALSSTYSAATMAA
MSMEG_4577|M.smegmatis_MC2_155 RPKVTTSGATPTEIADVYRRALADSGGDGVVAVHISAALSSTYSSAASAA
TH_0785|M.thermoresistible__bu RPNVTTAGATPLELSEAYRSALADSDGDGVVAVHISAALSGTFGSAVQTA
: .**:.*:* *: .*: ** ** * ******:*. **.* :* .*
Mb2440c|M.bovis_AF2122/97 AELGPAVRVIDSRSAAMGVGFAALAAGRAAAAG-----------------
Rv2417c|M.tuberculosis_H37Rv AELGPAVRVIDSRSAAMGVGFAALAAGRAAAAG-----------------
MMAR_3745|M.marinum_M ADLGPEVRVIDSKSAAMGTGFVALAAARAAAAG-----------------
MUL_3689|M.ulcerans_Agy99 ADLGPEVRVIDSKSAAMGTGFVALAAARAAAAG-----------------
MAV_1754|M.avium_104 ADLDPNLRVVDSKSAAMGTGFVALAAARAAAAG-----------------
MAB_1625|M.abscessus_ATCC_1997 RECGERVHVVDSQSAAMGSGFVALAAARAAAAG-----------------
Mflv_2657|M.gilvum_PYR-GCK REFGPAVRVVNSRSAAMGVGFIATAAARCAQAG-----------------
Mvan_3922|M.vanbaalenii_PYR-1 REFGPSVRVVNSRSAAMGVGFIALAAADCARSG-----------------
MSMEG_4577|M.smegmatis_MC2_155 REFSHAVRVVNSRSAAMGVGFAALAAARAAGAG-----------------
TH_0785|M.thermoresistible__bu REFGPAVRVVNSRSAAMGVGFVALAAARAXXXGRYAYHPFGVSASRTRSP
: . ::*::*:***** ** * **. . *
Mb2440c|M.bovis_AF2122/97 ---------------DELDTVARAAAAA----------------------
Rv2417c|M.tuberculosis_H37Rv ---------------DELDTVARAAAAA----------------------
MMAR_3745|M.marinum_M ---------------EDLESVGRAADAT----------------------
MUL_3689|M.ulcerans_Agy99 ---------------EDLESVGRAADAT----------------------
MAV_1754|M.avium_104 ---------------AQLDAVADAARAA----------------------
MAB_1625|M.abscessus_ATCC_1997 ---------------ADLSAAYQAARDA----------------------
Mflv_2657|M.gilvum_PYR-GCK ---------------GDLDTVEAAARSA----------------------
Mvan_3922|M.vanbaalenii_PYR-1 ---------------GDIDAVEAAARSA----------------------
MSMEG_4577|M.smegmatis_MC2_155 ---------------ASLDDVEAAARAA----------------------
TH_0785|M.thermoresistible__bu ITPFPARGMTGGEIRGTIDDFARSAELARRAGYDGVEIMGSEGYLINQFL
:. :* :
Mb2440c|M.bovis_AF2122/97 VSRIH------------------------------AFVAVARLDNLRRS-
Rv2417c|M.tuberculosis_H37Rv VSRIH------------------------------AFVAVARLDNLRRS-
MMAR_3745|M.marinum_M ASRTH------------------------------AFVVVHRLDNLRRS-
MUL_3689|M.ulcerans_Agy99 VSRTH------------------------------AFVVVHRLDNLRRS-
MAV_1754|M.avium_104 VSRGH------------------------------GFIVVHRLDNLRRS-
MAB_1625|M.abscessus_ATCC_1997 VGRSR------------------------------CVMVVHKLDHLRRS-
Mflv_2657|M.gilvum_PYR-GCK IAGSH------------------------------VFLVVHRLDNLRRS-
Mvan_3922|M.vanbaalenii_PYR-1 LTRSH------------------------------VFLVVHRLDNLRRS-
MSMEG_4577|M.smegmatis_MC2_155 AQRTH------------------------------AFIVVHRLDNLRRS-
TH_0785|M.thermoresistible__bu AARTNRRTDEWGGDPARRRRFAVEIVRRVRAAVGDDFLVIYRMSLLDLVP
. .:.: ::. *
Mb2440c|M.bovis_AF2122/97 -------------------------------GRIS--------GAKAWLG
Rv2417c|M.tuberculosis_H37Rv -------------------------------GRIS--------GAKAWLG
MMAR_3745|M.marinum_M -------------------------------GRIG--------GAKAWLG
MUL_3689|M.ulcerans_Agy99 -------------------------------GRIG--------GAKAWLG
MAV_1754|M.avium_104 -------------------------------GRIG--------GPAAWLG
MAB_1625|M.abscessus_ATCC_1997 -------------------------------GRIS--------ATSSWLG
Mflv_2657|M.gilvum_PYR-GCK -------------------------------GRIR--------TTASWLG
Mvan_3922|M.vanbaalenii_PYR-1 -------------------------------GRIR--------TAASWLG
MSMEG_4577|M.smegmatis_MC2_155 -------------------------------GRIG--------TAASWLG
TH_0785|M.thermoresistible__bu GGQTFADVTALAAEIEAAGVTMINTGIGWHESRVPTIVTSVPRAAFSWAT
.*: . :*
Mb2440c|M.bovis_AF2122/97 TALALKPLLSVDD-------------------------------------
Rv2417c|M.tuberculosis_H37Rv TALALKPLLSVDD-------------------------------------
MMAR_3745|M.marinum_M TALALKPLLRVED-------------------------------------
MUL_3689|M.ulcerans_Agy99 TALALKPLLRVED-------------------------------------
MAV_1754|M.avium_104 TALALKPLLRIDD-------------------------------------
MAB_1625|M.abscessus_ATCC_1997 TALALKPVLQIDEE------------------------------------
Mflv_2657|M.gilvum_PYR-GCK TALALKPLLCLDVD------------------------------------
Mvan_3922|M.vanbaalenii_PYR-1 TALALKPLLRLDVD------------------------------------
MSMEG_4577|M.smegmatis_MC2_155 TALALKPLLQLDID------------------------------------
TH_0785|M.thermoresistible__bu AALGRHVTVPVIASNRINMPEVAEEILARGDADLVSMARPFLADPEWVDK
:**. : : :
Mb2440c|M.bovis_AF2122/97 GKLVLVQRVRTVSNATAVMIDRVCQ-------------------------
Rv2417c|M.tuberculosis_H37Rv GKLVLVQRVRTVSNATAVMIDRVCQ-------------------------
MMAR_3745|M.marinum_M GKLVLAQRVRTVKHAMAALVDRVCE-------------------------
MUL_3689|M.ulcerans_Agy99 GKLVLAQRVRTVKHAMAALVDRVCE-------------------------
MAV_1754|M.avium_104 GKLVLAQRVRTAGHATEAMIDRVCQ-------------------------
MAB_1625|M.abscessus_ATCC_1997 GKLVLAQRVRTATKAIGAMVDNIVE-------------------------
Mflv_2657|M.gilvum_PYR-GCK GRLVLDQRIRTATKAHAAMVTRVAD-------------------------
Mvan_3922|M.vanbaalenii_PYR-1 GRLVLDQRIRTVGKAHAAMVERVAQ-------------------------
MSMEG_4577|M.smegmatis_MC2_155 GRLVLSQRIRTASKAHSALVEQVLE-------------------------
TH_0785|M.thermoresistible__bu ARQARSEEINTCIACNQACLDHAFARKRATCLVNPRAAYETELRLAPARR
.: . :.:.* . . : .
Mb2440c|M.bovis_AF2122/97 -----LVGD--------RPAALAVHHVADPAAANDVA--AALAERLP---
Rv2417c|M.tuberculosis_H37Rv -----LVGD--------RPAALAVHHVADPAAANDVA--AALAERLP---
MMAR_3745|M.marinum_M -----VVGR--------EPALLAVHHVANVEGANSVA--VELGRRLP---
MUL_3689|M.ulcerans_Agy99 -----VDGR--------EPALLAVHHVANVEGANSVA--VELGRRLP---
MAV_1754|M.avium_104 -----VVGE--------GAAALAVHHVDNPGGAAEVA--AALGERLP---
MAB_1625|M.abscessus_ATCC_1997 -----FVGE--------RRVSVTIHHVDNTETAEKVN--ELVCSRLV---
Mflv_2657|M.gilvum_PYR-GCK -----VVGE--------RPAELVVHHVDNHDAADELG--AALTQRLP---
Mvan_3922|M.vanbaalenii_PYR-1 -----VVGD--------RGADVVVHHVDNHDAADELG--AALTRRLP---
MSMEG_4577|M.smegmatis_MC2_155 -----EAGD--------RLVDVVVHHVDNPEAAEEIG--KQLTERLP---
TH_0785|M.thermoresistible__bu PLRIAVVGAGPAGLAAATTAAVRGHTVDLFEAAGVIGGQFQLARRIPGKE
* . : * * * : : *:
Mb2440c|M.bovis_AF2122/97 ------------------------ACEPAMVTAMG---PVLA--------
Rv2417c|M.tuberculosis_H37Rv ------------------------ACEPAMVTAMG---PVLA--------
MMAR_3745|M.marinum_M ------------------------ACEPALVTPLG---PVLA--------
MUL_3689|M.ulcerans_Agy99 ------------------------ACEPALVTPLG---PVLA--------
MAV_1754|M.avium_104 ------------------------ACDPAIITELG---PVLA--------
MAB_1625|M.abscessus_ATCC_1997 ------------------------TAHEPVISEMG---PVLA--------
Mflv_2657|M.gilvum_PYR-GCK ------------------------QLSSLTVADMG---PLLS--------
Mvan_3922|M.vanbaalenii_PYR-1 ------------------------QISSLTVADMG---PLLS--------
MSMEG_4577|M.smegmatis_MC2_155 ------------------------ALRSLEVADMG---PVLA--------
TH_0785|M.thermoresistible__bu EFAETIRYFTRRLEITGVKLHLNHRVTAAELLDAGYDDIVLATGVAPRIP
: * :*:
Mb2440c|M.bovis_AF2122/97 ---------LH------------------VGAGAVGVCVDVGASPPA---
Rv2417c|M.tuberculosis_H37Rv ---------LH------------------VGAGAVGVCVDVGASPPA---
MMAR_3745|M.marinum_M ---------LH------------------VGAEAVAVCVQVGAASLRG--
MUL_3689|M.ulcerans_Agy99 ---------LH------------------VGAEAVAVCVQVGAASLRG--
MAV_1754|M.avium_104 ---------LH------------------VGAGAVAVVVQQPGS------
MAB_1625|M.abscessus_ATCC_1997 ---------VH------------------VGPGAVGVCAEPVD-------
Mflv_2657|M.gilvum_PYR-GCK ---------VH------------------VGGGAVGVAVQVRRPNGR---
Mvan_3922|M.vanbaalenii_PYR-1 ---------IH------------------VGGGAVGVAVQVH--------
MSMEG_4577|M.smegmatis_MC2_155 ---------VH------------------VGGGAVGVALSVDPES-----
TH_0785|M.thermoresistible__bu DIPGIDRPNVHGYAEVITGQVDIGRRIAVIGAGGIGVDVTTLLTHGGVRP
:* :* .:.*
Mb2440c|M.bovis_AF2122/97 --------------------------------------------------
Rv2417c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3745|M.marinum_M --------------------------------------------------
MUL_3689|M.ulcerans_Agy99 --------------------------------------------------
MAV_1754|M.avium_104 --------------------------------------------------
MAB_1625|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2657|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3922|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4577|M.smegmatis_MC2_155 --------------------------------------------------
TH_0785|M.thermoresistible__bu QPVADWLREWGVADPAEHPGGLTGAQPPAPAREVYLLQRKRSQIGAGLGK
Mb2440c|M.bovis_AF2122/97 --------------------------------------------------
Rv2417c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3745|M.marinum_M --------------------------------------------------
MUL_3689|M.ulcerans_Agy99 --------------------------------------------------
MAV_1754|M.avium_104 --------------------------------------------------
MAB_1625|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2657|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3922|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4577|M.smegmatis_MC2_155 --------------------------------------------------
TH_0785|M.thermoresistible__bu TTGWVHRATLRHRGVHQLTGVRYHRIDQAGLHISVDGRDRVLDVDDIVVC
Mb2440c|M.bovis_AF2122/97 ------------------------------------------------
Rv2417c|M.tuberculosis_H37Rv ------------------------------------------------
MMAR_3745|M.marinum_M ------------------------------------------------
MUL_3689|M.ulcerans_Agy99 ------------------------------------------------
MAV_1754|M.avium_104 ------------------------------------------------
MAB_1625|M.abscessus_ATCC_1997 ------------------------------------------------
Mflv_2657|M.gilvum_PYR-GCK ------------------------------------------------
Mvan_3922|M.vanbaalenii_PYR-1 ------------------------------------------------
MSMEG_4577|M.smegmatis_MC2_155 ------------------------------------------------
TH_0785|M.thermoresistible__bu AGQLPQRELHAELSAAGMSVHLAGGAAVAAELDAKRAIAEGTRLAARI