For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHVDLLWSLSRAPDADAALRALIRLSENP DTGWDELNAALLRERSLRGRLFSVLGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECVEESEG MPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADAALAAALRVAEASVCGEHPPP RLAVIAMGKCGARELNYVSDVDVIFVAERSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLE SHIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDFVVEVQAMRRRVEQLVPADV RGRELKLGSGGLRDVEFAVQLLQLVHARSDESLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLE HRLQLQRLKRTHLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHTKLFYQPLLES IGPTGLEIAHGMTLEAAGRRLAALGYEGPQTALKHMSALVNQSGRRGRVQSVLLPRLLDWMSYAPDPDGG LLAYRRLSEALATESWYLATLRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPA AVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCRALTSVWVAVLQAALDVMIRA SLPDDDRAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPATGVDDARAVKWSTSIAERVRALLGTPSVDP PLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDAELGQRFLRMVDKTRYPPDGV SADSVREIRRIKARIESERLPRGADPNTHTKLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVI AAADLVPAADVELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRNDDGGEFLDNYLRV TRRAKAVVRKVFGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2245c | glnE | - | 100% (994) | glutamate-ammonia-ligase adenylyltransferase GLNE (glutamine-synthetase adenylyltransferase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2910 | - | 0.0 | 72.16% (995) | (glutamate--ammonia-ligase) adenylyltransferase |
| M. tuberculosis H37Rv | Rv2221c | glnE | 0.0 | 100.00% (994) | glutamate-ammonia-ligase adenylyltransferase GLNE |
| M. leprae Br4923 | MLBr_01630 | glnE | 0.0 | 82.87% (998) | bifunctional glutamine-synthetase |
| M. abscessus ATCC 19977 | MAB_1921 | - | 0.0 | 70.67% (992) | glutamate-ammonia-ligase adenylyltransferase GlnE |
| M. marinum M | MMAR_3293 | glnE | 0.0 | 84.69% (993) | glutamate-ammonia-ligase adenylyltransferase GlnE |
| M. avium 104 | MAV_2245 | - | 0.0 | 85.37% (998) | glutamate-ammonia-ligase adenylyltransferase |
| M. smegmatis MC2 155 | MSMEG_4293 | - | 0.0 | 73.68% (1003) | glutamate-ammonia-ligase adenylyltransferase |
| M. thermoresistible (build 8) | TH_0214 | glnE | 0.0 | 73.35% (1013) | GLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE GLNE |
| M. ulcerans Agy99 | MUL_1336 | glnE | 0.0 | 84.09% (993) | glutamate-ammonia-ligase adenylyltransferase GlnE |
| M. vanbaalenii PYR-1 | Mvan_3597 | - | 0.0 | 73.17% (995) | (glutamate--ammonia-ligase) adenylyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2910|M.gilvum_PYR-GCK ------MGVAKPATQRPKLPGVGRLGLVEPTAQADLDRLGWN---TDAHV
Mvan_3597|M.vanbaalenii_PYR-1 ------MGVAKPATQRPRLPGVGRLGLVEPTAQADLDTLGWN---TDAHV
MSMEG_4293|M.smegmatis_MC2_155 ------MFVRKPATERPRLPSVGRLGLFDPHAPAHLDQLGWN---TDDHV
TH_0214|M.thermoresistible__bu --------VTGPVTDRPTLPGPGRLGLVRRDARDHLDALGWN---TDDHV
Mb2245c|M.bovis_AF2122/97 ------MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHV
Rv2221c|M.tuberculosis_H37Rv ------MVVTKLATQRPKLPSVGRLGLVDPPAGERLAQLGWDRHEDQAHV
MMAR_3293|M.marinum_M ------MNVTKPATQRPKLPSVGRLGLVDALAGARLAELGWTEHDDQAHV
MUL_1336|M.ulcerans_Agy99 ------MNVTKPATQRPKLPSVGRLGLVDALAGAHLAELGWTEHDDQAHV
MLBr_01630|M.leprae_Br4923 MCCTTVVVVRKPATERLKRPSVGRLGLFDPHAAENLALLGWYDYDCREHV
MAV_2245|M.avium_104 ------MVVTKPATQRPRLPSVGRLGLVDPQAAERMAQLGWYDHDDQAHV
MAB_1921|M.abscessus_ATCC_1997 ---------MTRSSERSKVPGVGRLGLVDPRAAALLEELGWT---TEAHV
::* *. *****. * : *** **
Mflv_2910|M.gilvum_PYR-GCK ELLWALSRAPDADKALKAIVRLAEALDAEWDAVDAALLKDRGLRGRLFGI
Mvan_3597|M.vanbaalenii_PYR-1 ELLWSLSRAPDADTALKAIVRLSEALGPGWAELDGELLTDRSLRGRLFAV
MSMEG_4293|M.smegmatis_MC2_155 ELLWSLSRAPDADAALLAMVRLADELKDDWDELNRLLLTDRPLRGRLFAV
TH_0214|M.thermoresistible__bu DLLWSLSRAPDADLALHTMVRLAEAVGDDWPRLHQTLLRDRSLRGRLFSV
Mb2245c|M.bovis_AF2122/97 DLLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSV
Rv2221c|M.tuberculosis_H37Rv DLLWSLSRAPDADAALRALIRLSENPDTGWDELNAALLRERSLRGRLFSV
MMAR_3293|M.marinum_M DLLWSLSRAPDADAALKVLVRLAENPDTGWDELNAALLNERSLRGRLFAV
MUL_1336|M.ulcerans_Agy99 DLLWSLSRAPDADAALKVLVRLAENPDTGWDELNAALLNERSLRGRLFAV
MLBr_01630|M.leprae_Br4923 DLLWSLSRAPDADAVLRPMVRLFENPATGWDELNAALLTDRGLRGRLFAV
MAV_2245|M.avium_104 DLLWALSRAPDPDAALLALVRLAETPDAGWDELGAALLTERPLRGRLFAV
MAB_1921|M.abscessus_ATCC_1997 PLLWSLSRSPDADAALLTLIRLREEMGPQWAALDQELSANTALRGRLLSV
***:***:**.* .* ::** : * : * : *****:.:
Mflv_2910|M.gilvum_PYR-GCK LGSSLALGDHLIAHPASWRLLAGSVTLPDPQQLRDMFAEEAD--KATGP-
Mvan_3597|M.vanbaalenii_PYR-1 LGSSLALGDHLVANLDSWRLLAGNVKLPYPQELREMFADQAD--RVDG--
MSMEG_4293|M.smegmatis_MC2_155 LGSSLALGDHLVAHPQSWRLLHGDVRLPSARELRETFDDAAR--SVDIER
TH_0214|M.thermoresistible__bu LGSSAALGDHMVAHPDAWQMLAGDVRLPTFDELRTTFVDAAR--DTDDPR
Mb2245c|M.bovis_AF2122/97 LGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECV----EESEG
Rv2221c|M.tuberculosis_H37Rv LGSSLALGDHLVAHPQSWKLLRGKVTLPSHDQLQRSFVECV----EESEG
MMAR_3293|M.marinum_M LGSSLSLGDHLVANPQSWKLLRGKVALPSHAALLESFVDLA----EEVAA
MUL_1336|M.ulcerans_Agy99 LGSSLSLGDHLVANPQSWKLLRGKVALPSHAALLESFVDLA----EEVAA
MLBr_01630|M.leprae_Br4923 LGSSLALGDHLVAHPQSWKLLRGRVSLPSRTQLHQAFDECVSNFGDDPLD
MAV_2245|M.avium_104 LGSSLALGDHLVAQPRSWKLLRGNVSLPTHDELCAMFTGCV----DEALA
MAB_1921|M.abscessus_ATCC_1997 IGSSLALGDHLVAHPDRWQLLVGEVELESKETLQERFLKVVGAIDGRASV
:*** :****::*: *::* * * * * * .
Mflv_2910|M.gilvum_PYR-GCK -TAAAVPPLRTLYRDRLLVLGALDVASVVENEPVLPFTVVGEHLSDLADA
Mvan_3597|M.vanbaalenii_PYR-1 -ATAAIPPLRTLYRDRLLVLAALDVASTVENEPVLPFSVVGEHLSDLADA
MSMEG_4293|M.smegmatis_MC2_155 GASAAIPPLRDLYRDRLLVLAALDVASTVENEPVLPFVTVSAHLSDLADA
TH_0214|M.thermoresistible__bu ATSALVPRLRRLYRDQILLLAALDLASVVEDEPWMPVTEVGAQLSDMADA
Mb2245c|M.bovis_AF2122/97 MPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADA
Rv2221c|M.tuberculosis_H37Rv MPGSLVHRLRTQYRDYVLMLAALDLAATVEDEPVLPFTVVAARLADAADA
MMAR_3293|M.marinum_M APASAVHRLRALHRDHVLVLAGLDLAATVEDEPVLPFTVVAAHLADIADA
MUL_1336|M.ulcerans_Agy99 APASAVHRLRALHRDHVLVLAGLDLAATVEDEPVLSFTVVAAHLADIADA
MLBr_01630|M.leprae_Br4923 APDSVLPRLRTLYCDQLLVLAALDLAATVEDEPVLPFTLVAAQLADIADA
MAV_2245|M.avium_104 DPGSAMVRLRTLYRDRLLVLAALDLAATVEDEPVLPFTVVAAHLSDLADA
MAB_1921|M.abscessus_ATCC_1997 SEFVAISALRDAYRDRLLVLAALDLAATVENEPVLPFPVVGQHLADLADA
: ** : * :*:*..**:*:.**:** :.. *. :*:* ***
Mflv_2910|M.gilvum_PYR-GCK ALAGALRVVTASVCGDT-PAPALTIIAMGKCGARELNYVSDVDVIFVTD-
Mvan_3597|M.vanbaalenii_PYR-1 ALAAALRVVTASVCGDQ-PAPALSVIAMGKCGAQELNYVSDVDVIFVTD-
MSMEG_4293|M.smegmatis_MC2_155 ALSAALIVATRTVCGD--LDPRLAVIAMGKCGARELNYVSDVDVIFVGED
TH_0214|M.thermoresistible__bu ALAAALTVATRAVCGDE-PPPRLAVIAMGKCGARELNYVSDVDVIFVAD-
Mb2245c|M.bovis_AF2122/97 ALAAALRVAEASVCGEH-PPPRLAVIAMGKCGARELNYVSDVDVIFVAE-
Rv2221c|M.tuberculosis_H37Rv ALAAALRVAEASVCGEH-PPPRLAVIAMGKCGARELNYVSDVDVIFVAE-
MMAR_3293|M.marinum_M ALAAALRLAEKTVCRDR-TPPRLAVIAMGKCGARELNYVSDVDVIFVAE-
MUL_1336|M.ulcerans_Agy99 ALAAALRLAEKTVCRDR-TPPRLAVIAVGKCGARELNYVSDVDVIFVAE-
MLBr_01630|M.leprae_Br4923 AMATALRVAEKIVCGDR-TPPRLAVIAMGKWGARELNYVSDVDIIFVAE-
MAV_2245|M.avium_104 ALAAALRVAEHNVCGDR-TPPRLAVIAMGKCGARELNYVSDVDVIFVGE-
MAB_1921|M.abscessus_ATCC_1997 ALTAALAVAVSLVVPEGQEPPRLAVIAMGKCGARELNYVSDVDVIFVGE-
*:: ** :. * : * *::**:** **:*********:*** :
Mflv_2910|M.gilvum_PYR-GCK ---DGSHSSLALATRIAGEMMRLASDAFFEVDAALRPEGKQGQLVRTLES
Mvan_3597|M.vanbaalenii_PYR-1 ---DGSHSSLALATRIAGEMMRLASEAFFEVDAALRPEGKQGQLVRTLDS
MSMEG_4293|M.smegmatis_MC2_155 IEKDGRSDNLATATRVAGEMMRFAGDAFFEVDAALRPEGKRGQLVRTLDS
TH_0214|M.thermoresistible__bu ---DAEPDQLTVATRIAGQLMRFAADAFFEVDAALRPEGKRGQLVRTLDS
Mb2245c|M.bovis_AF2122/97 -------RSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLES
Rv2221c|M.tuberculosis_H37Rv -------RSDPRNARVASEMMRVASAAFFEVDAALRPEGRNGELVRTLES
MMAR_3293|M.marinum_M -------RADPISIRVAGEMMRVASSTFFEVDAGLRPEGRSGELVRTVES
MUL_1336|M.ulcerans_Agy99 -------RADPISIRVAGEMMRVASSTFFEVDAGLRPEGRSGELVRTVES
MLBr_01630|M.leprae_Br4923 -------QADPLSTRVASEMMRVASEAFFQVDAGLRPEGRNGELVRTVES
MAV_2245|M.avium_104 -------RADTVTTRVASEMMRLASEAFFQVDAGLRPEGRSGELVRTVES
MAB_1921|M.abscessus_ATCC_1997 -------QADSLTTRVAGEMMRVGSSTFFEVDAALRPEGKAGALVRTLDS
. *:*.::**... :**:***.*****: * ****::*
Mflv_2910|M.gilvum_PYR-GCK HIAYYERWAKTWEFQALLKARPCAGDMELGNRYIEALMPMVWTASEREDF
Mvan_3597|M.vanbaalenii_PYR-1 HIAYYERWAKTWEFQALLKARPAAGDMELGNRYTEALMPMVWTASEREDF
MSMEG_4293|M.smegmatis_MC2_155 HVAYYRRWAKTWEFQALLKARPAAGDPELGQAYIDALMPMVWTACEREDF
TH_0214|M.thermoresistible__bu HVAYYRRWAKTWEFQALMKARPAAGDPELGQRYIDAVMPMVWTASEREDF
Mb2245c|M.bovis_AF2122/97 HIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDF
Rv2221c|M.tuberculosis_H37Rv HIAYYQRWAKTWEFQALLKARPVVGDAELGERYLTALMPMVWRACEREDF
MMAR_3293|M.marinum_M HIAYYQRWAKTWEFQALLKARAAVGDAELGQSYLAALMPMVWTACERDDF
MUL_1336|M.ulcerans_Agy99 HIAYYQRWAKTWEFQALLKARAAVGDAELGQRYLAALMPMVWTACERDDF
MLBr_01630|M.leprae_Br4923 HIAYYQRWAKTWEFQALLKARSAVGDAELGERYLAALMPMVWAACERADF
MAV_2245|M.avium_104 HIAYYQRWAKTWEFQALLKARAAVGDAELGRRYLDALMPMVWVACEREDF
MAB_1921|M.abscessus_ATCC_1997 HVTYYRRWAKTWEFQALLKARPAVGDPDLGKAYVDALMPMVWTACEREDF
*::**.***********:***. .** :**. * *:***** *.** **
Mflv_2910|M.gilvum_PYR-GCK VPEVQAMRRRVEELVPAGVRTREIKLGTGGLRDVEFAVQLLQLVHGRNDD
Mvan_3597|M.vanbaalenii_PYR-1 VPEVQAMRRRVEELVPAGVRTREIKLGSGGLRDVEFAVQLLQLVHGRNDE
MSMEG_4293|M.smegmatis_MC2_155 VPEVQAMRRRVEELVPADVRSREIKLGTGGLRDVEFAVQLLQLVHGRTDE
TH_0214|M.thermoresistible__bu VAEVQAMRRRVESLVPADRRERELKLGTGGLRDVEFAVQLLQLVHGRTDE
Mb2245c|M.bovis_AF2122/97 VVEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDE
Rv2221c|M.tuberculosis_H37Rv VVEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHARSDE
MMAR_3293|M.marinum_M VAEVQAMRRRVEQLVPADIRGRELKLGTGGLRDVEFVAQLLQLVHGRSDE
MUL_1336|M.ulcerans_Agy99 VAEVQAMRRRVEQLVPADIRGRELKLGTGGLRDVEFVAQLLQLVHGRSDE
MLBr_01630|M.leprae_Br4923 VAEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHGRSDE
MAV_2245|M.avium_104 VVEVQAMRRRVEQLVPADVRGREIKLGSGGLRDVEFAVQLLQLVHGRSDE
MAB_1921|M.abscessus_ATCC_1997 VPEVQAMRRRVESLVPADLREREIKLGTGGLRDVEFAVQLLQLVHGRADE
* **********.****. * **:***:********..*******.* *:
Mflv_2910|M.gilvum_PYR-GCK SLHVASTVNALAALGQAGYVGRDDAANLTASYEFLRLLEHRLQLQRLKRT
Mvan_3597|M.vanbaalenii_PYR-1 SLHVASTVNALAALGDGGYIGRDDAANMTASYEFLRLLEHRLQLQRLKRT
MSMEG_4293|M.smegmatis_MC2_155 SLHVASTVDALAALGEGGYVGRDDAANMTASYEFLRLLEHRLQLQRLKRT
TH_0214|M.thermoresistible__bu SLRVASTVDALTALGAGGYIGRDDAANMRASYEFLRLLEHRLQLQRLKRT
Mb2245c|M.bovis_AF2122/97 SLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLEHRLQLQRLKRT
Rv2221c|M.tuberculosis_H37Rv SLRVASTVDALAALGEGGYIGREDAANMTASYEFLRLLEHRLQLQRLKRT
MMAR_3293|M.marinum_M SLHVASTVDALSALGEGGYIGREDAANMIASYEFLRLLEHRLQLQRLKRT
MUL_1336|M.ulcerans_Agy99 SLHVASTVDALSALGEGGYIGREDAANMIASYEFLRLLEHRLQLQRLKRT
MLBr_01630|M.leprae_Br4923 SLHVVSTVDALAALGEGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRT
MAV_2245|M.avium_104 SLHVASTVDALAALGQGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRT
MAB_1921|M.abscessus_ATCC_1997 SLHVASTVDALSVLSAGGYIGRDDGANLTASYEFLRLLEHRLQLQRLKRT
**:*.***:**:.*. .**:**:*.**: *********************
Mflv_2910|M.gilvum_PYR-GCK HMLPEADDEEAMRWLARAAHMRPDGRHDALGVLREELKRQSHRVSRLHAK
Mvan_3597|M.vanbaalenii_PYR-1 HMLPEADDEESMRWLARAAHMRPDGRHDALGVLREELKRQNHRVSRLHAK
MSMEG_4293|M.smegmatis_MC2_155 HMLPDDNDDEAYRWLARAAHIRPDGTHDAQGVLREELKRQSLRVSRLHAK
TH_0214|M.thermoresistible__bu HLLPEPDDDEALRWLARAAHIRPDGRHDALGVLREELKRQSRRVSRLHAK
Mb2245c|M.bovis_AF2122/97 HLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHTK
Rv2221c|M.tuberculosis_H37Rv HLLPDPEDEEAVRWLARAAHIRPDGRNDAAGVLREELKKQNVRVSKLHTK
MMAR_3293|M.marinum_M HLLPEFDDEEAVRWLARAAHIRPDGRHDAAGMLREELKHQNVRVSRLHAK
MUL_1336|M.ulcerans_Agy99 HLLPEFDDEEAVRWLARAAHIRPDGRHDAAGMLREELKHQNVRVSRLHAK
MLBr_01630|M.leprae_Br4923 HLLPEDGDEEAVRWLARAAHIRPDGRHDAAGVLREELKNQNLRVSQLHAK
MAV_2245|M.avium_104 HLLPEADDEEAVRWLARAAHIRPDGRHDAAGVLREELRHQNLRVSQLHAK
MAB_1921|M.abscessus_ATCC_1997 HTLPAPEDTEAMRWLARAAHVRPDGQNDALGVLRAEIKRQALRVSRLHAK
* ** * *: ********:**** :** *:** *::.* ***:**:*
Mflv_2910|M.gilvum_PYR-GCK LFYQPLLESVGQASVGLS-DVMSTDAAERQLAALGYEGPQSALTHLAALT
Mvan_3597|M.vanbaalenii_PYR-1 LFYQPLLESVGQASLGLS-DVMSTDAAERQLAALGYEGPQSALTHLAALT
MSMEG_4293|M.smegmatis_MC2_155 LFYQPLLESVGHTALGIG-EGMSAEAAERQLAALGYERPQSALAHLAALT
TH_0214|M.thermoresistible__bu LFYQPLLESVGQPVQGIT-ASMPTESAERLLAALGYDGPQNALTHLAALT
Mb2245c|M.bovis_AF2122/97 LFYQPLLESIGPTGLEIA-HGMTLEAAGRRLAALGYEGPQTALKHMSALV
Rv2221c|M.tuberculosis_H37Rv LFYQPLLESIGPTGLEIA-HGMTLEAAGRRLAALGYEGPQTALKHMSALV
MMAR_3293|M.marinum_M LFYQPLLESIAPAGLEIAGRGMTSEAAERQLAALGYEGPQTALKHMAALV
MUL_1336|M.ulcerans_Agy99 LFYQPLLESIAPAGLEIAGRGMTSEAAERQLAALGYEGPQTALKHMAALV
MLBr_01630|M.leprae_Br4923 LFYQPLLESIGPASLEIR-HGMTSEAAERQLATLGYEGSQTALKHISALV
MAV_2245|M.avium_104 LFYQPLLESIGPAGLEIR-HGMTSEAAERQLAALGYEGPQSALKHMSALV
MAB_1921|M.abscessus_ATCC_1997 LFYQPLLESVTEFDKEAL--GLSNEAAVRQLAALGYQQPQHALSHLAALT
*********: :. ::* * **:***: .* ** *::**.
Mflv_2910|M.gilvum_PYR-GCK GGSGRRARVQQVLLPTLLDWLSDTPDPDAGLLNYRRISDELAEARWYLAT
Mvan_3597|M.vanbaalenii_PYR-1 GSSGRRGRVQQVLLPTLLDWLSDTPDPDAGLLAYRRISDELAEQRWYLAT
MSMEG_4293|M.smegmatis_MC2_155 GATGRKGRIQQILLPTLLDWLSDTPDPDAGLLAYRRLSDEHSDLRWFLGT
TH_0214|M.thermoresistible__bu GQSGRRGRVQRVLLPTLLEWLADTPDPDGGLLAYRRISEALADQRWYLAT
Mb2245c|M.bovis_AF2122/97 NQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLAT
Rv2221c|M.tuberculosis_H37Rv NQSGRRGRVQSVLLPRLLDWMSYAPDPDGGLLAYRRLSEALATESWYLAT
MMAR_3293|M.marinum_M NHSGRRARVQSVLLPRLLDWLSYAPDPDGGLLAYRRLSEALATQSWYLST
MUL_1336|M.ulcerans_Agy99 NHSGRRARVQSVLLPRLLDWLSYAPDPDGGLLAYRRLSEALAPQSWYLST
MLBr_01630|M.leprae_Br4923 NQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALSAETWYLST
MAV_2245|M.avium_104 NQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALAGESWYLST
MAB_1921|M.abscessus_ATCC_1997 KEGGRRGRIQSILLPTLLDWLADTPDPDAGLLAYRRVSEALADQTWYLRT
**:.*:* :*** **:*:: :****.*** ***:*: : *:* *
Mflv_2910|M.gilvum_PYR-GCK LRDEGAVAKRLMHVLGTSAYVPELLMKAPEVIQLYADGPNGPKLCDVDTE
Mvan_3597|M.vanbaalenii_PYR-1 LRDEGAVAKRLMHVLGTSAYVPELLMRAPEVIQLYADGPNGPKLCDVDTE
MSMEG_4293|M.smegmatis_MC2_155 LRDEGAVAKRLMRVLGTSAYIPELLMRAPEVIQMYADGPSGPKLLEDDRE
TH_0214|M.thermoresistible__bu LRDEGAVAKRLMRVLGTSAYVPDLLMRAPDVIQSYADGPDGPKLLETDPE
Mb2245c|M.bovis_AF2122/97 LRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPA
Rv2221c|M.tuberculosis_H37Rv LRDKPAVAKRLMHVLGTSAYVPDLLMRAPRVIQQYEDGPAGPKLLETEPA
MMAR_3293|M.marinum_M LRDKPTVGRRLMHVLGTSAFVPDLLMRAPEVIQNYGDGRTGPKLLETEPA
MUL_1336|M.ulcerans_Agy99 LRDKPTVGRRLMHVLGTSAFVPDLLMRAPEVIQNYGDSRTGPKLLETEPA
MLBr_01630|M.leprae_Br4923 LRDKPAVARRLMHVLGTSVYVPDLLMRAPEVIQSYGDGLAGPKLLEAEPA
MAV_2245|M.avium_104 LRDKPAVARRLMHVLGTSAYVPDLLMRAPRVIQDYGDGPSGPRLLETDPA
MAB_1921|M.abscessus_ATCC_1997 LRDEGAVAKRLMQILGTSAYVPDLVMRAPEVIQLYADGPNGPKLLEAEPA
***: :*.:***::****.::*:*:*:** *** * *. **:* : :
Mflv_2910|M.gilvum_PYR-GCK SAAKSLVNSAARHADPMRAIAAARSLRRRELARIASADLLGMLHVTEVCK
Mvan_3597|M.vanbaalenii_PYR-1 SFAKSLVASAARHADPMRAIAAARSLRRRELARIASADLLGMLDVTAVCK
MSMEG_4293|M.smegmatis_MC2_155 SRARALVASASRYADPVRAIAAARTLRRRELARIASADVLGMLDVIDVCK
TH_0214|M.thermoresistible__bu SVARALIASAARYPDPVRAIAAARTLRRRELARVASADLLGMLDVVEVCR
Mb2245c|M.bovis_AF2122/97 AVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCR
Rv2221c|M.tuberculosis_H37Rv AVARALIASASRYPDPERAIAGARTLRRRELARIGSADLLGLLEVTEVCR
MMAR_3293|M.marinum_M AVARALIASAGRYSDPLRAIAAARTLRRRELARIGSADLLGLLEVTEVCR
MUL_1336|M.ulcerans_Agy99 AVARALIASAGRYSDPLRAIAAARTLRRRELARIGSADLLGLLEVTEVCR
MLBr_01630|M.leprae_Br4923 MVARALITSAGRHTDPIRAIDAARSLRRRELARVGSADLLGLLEVTEVCK
MAV_2245|M.avium_104 AVARALVASASRYSDPVRAIAGARTLRRRELARVASADLLGMLEVTDVCK
MAB_1921|M.abscessus_ATCC_1997 SVAKALIASSARHADPERAIAAARSLRRRELARVASADLLGLLDVVEVCG
*::*: *:.*:.** *** .**:********:.***:**:*.* **
Mflv_2910|M.gilvum_PYR-GCK QLTQVWVAVLQAALDALTRANTPEAG-----VPARIAVIGMGRLGGGELG
Mvan_3597|M.vanbaalenii_PYR-1 QLTLVWVAVLQAALDAVIRANSPDGK-----APARIAVIGMGRLGGGELG
MSMEG_4293|M.smegmatis_MC2_155 SLTAVWVAVLQAALDVVIRANTPDSG-----VPARIAVIGMGRLGGGELG
TH_0214|M.thermoresistible__bu ALTSVWVAVLQAALDAVIRANSRDGQ-----APARIAVIGMGRLGGGELG
Mb2245c|M.bovis_AF2122/97 ALTSVWVAVLQAALDVMIRASLPDDD----RAPAAIAVIGMGRLGGAELG
Rv2221c|M.tuberculosis_H37Rv ALTSVWVAVLQAALDVMIRASLPDDD----RAPAAIAVIGMGRLGGAELG
MMAR_3293|M.marinum_M ALTSVWVAVLQSALEAMIRANTPEGG----RPLARIAVIGMGRLGGSELS
MUL_1336|M.ulcerans_Agy99 ALTSVWVAVLQSALEAMIRANTPEGG----RPLARIAVIGMGRLGGSELS
MLBr_01630|M.leprae_Br4923 ALTSVWVAVLQAALDAVIRAYLPDGD----KAPAAIAVIGMGRLGGAELG
MAV_2245|M.avium_104 ALTSVWVAVLQAALDAMIRANLPDDGPQRGKAPAAIAVIGMGRLGGAELG
MAB_1921|M.abscessus_ATCC_1997 ALTSVWVAVLQAALDAVIKASIPEGE----QAPAVVSVIGMGRLGGGELG
** *******:**:.: :* : * ::*********.**.
Mflv_2910|M.gilvum_PYR-GCK YGSDADVLFVCEPADGVE------ESVAVKWAVTIAEQVRARLGTPSSDP
Mvan_3597|M.vanbaalenii_PYR-1 YGSDADVMFVCEPHAGVE------ESTAVKWSTTVAEQVRARLGTPSADP
MSMEG_4293|M.smegmatis_MC2_155 YGSDADVMFVCEPNSGVE------ESVAVRWSVGVAEQVRALLGTPSADP
TH_0214|M.thermoresistible__bu YGSDADVMFVCEPVEGADTGPNGDESGVVRWATGIAEQVTALLGTPSVDP
Mb2245c|M.bovis_AF2122/97 YGSDADVMFVCEPATGVD------DARAVKWSTSIAERVRALLGTPSVDP
Rv2221c|M.tuberculosis_H37Rv YGSDADVMFVCEPATGVD------DARAVKWSTSIAERVRALLGTPSVDP
MMAR_3293|M.marinum_M YGSDADVMYVCEPASGVT------DAQAVKWSTAVAEQVRAKLGTPSVDP
MUL_1336|M.ulcerans_Agy99 YGSDADVMYVCEPASGVT------DAQGVKWSTAVAEQVRAKLGTPSVDP
MLBr_01630|M.leprae_Br4923 YGSDADVMFVCEPAIGVE------DAQALRWSGMIAERVCRLLRTPSVDP
MAV_2245|M.avium_104 YGSDADVMFVCEPAPGVD------DSAAVRWAASVAEQVRTLLGTPSVDP
MAB_1921|M.abscessus_ATCC_1997 YGSDADVLYVCEARGEAT------DAEAVRWSATIAEKVGKLLGAPSTDP
*******::***. . :: ::*: :**:* * :** **
Mflv_2910|M.gilvum_PYR-GCK PLEVDTNLRPEGRNGPLVRTLASYEAYYAQWAQPWEVQALLRAHRVAGDL
Mvan_3597|M.vanbaalenii_PYR-1 PLEVDANLRPEGRSGPLVRTLASYEAYYTQWAQAWEVQALLRAHRVAGDL
MSMEG_4293|M.smegmatis_MC2_155 PLEVDTGLRPEGRSGPLVRTLASYDAYYSQWAQPWEIQALLRAHRVAGDL
TH_0214|M.thermoresistible__bu PLELDTTLRPEGRNGPLVRTLASYAAYYKQWAQPWEVQALLRAHAVAGDP
Mb2245c|M.bovis_AF2122/97 PLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDA
Rv2221c|M.tuberculosis_H37Rv PLELDANLRPEGRNGPLVRTLGSYAAYYEQWAQPWEIQALLRAHAVAGDA
MMAR_3293|M.marinum_M PLEVDANLRPEGRNGPLVRTLASYEAYYAQWAQAWEIQALLRAHAVAGDA
MUL_1336|M.ulcerans_Agy99 PLEVDANLRPEGRNGPLVRTLASYGAYYAQWAQAWEIQALLRAHAVAGDA
MLBr_01630|M.leprae_Br4923 PLDVDANLRPEGRNGPLVRTLGAYAAYYAQWAQPWEIQALLRAHAVAGDA
MAV_2245|M.avium_104 PLDVDANLRPEGRNGPLVRTLASYAAYYEQWAQPWEIQALLRAHAVAGDA
MAB_1921|M.abscessus_ATCC_1997 PLQVDTGLRPEGRNGPMVRTLAAYETYYAQWAQPWEVQALLRAHSVAGDS
**::*: ******.**:****.:* :** ****.**:******* ****
Mflv_2910|M.gilvum_PYR-GCK ELGERFLLMIDKIRYPAGGASAETVQEIRRIKARVDAERLPRGADPNTHT
Mvan_3597|M.vanbaalenii_PYR-1 ELGERFLLMIDKTRYPAGGVSPETVREIRRIKARVDAERLPRGADPNTHT
MSMEG_4293|M.smegmatis_MC2_155 ELGERFLLMADKIRYPEGGVSASAVQEIRRIKARVDAERLPRGADPNTHT
TH_0214|M.thermoresistible__bu DLGQRFLRMIDDVRYPPGGVAPEAVREIKRIKARVDAERLPRGADPNTHT
Mb2245c|M.bovis_AF2122/97 ELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHT
Rv2221c|M.tuberculosis_H37Rv ELGQRFLRMVDKTRYPPDGVSADSVREIRRIKARIESERLPRGADPNTHT
MMAR_3293|M.marinum_M ELGQRFLLLVDHTRYPPDGVSAEAVHEIRRIKARVESERLPRGADPNTHT
MUL_1336|M.ulcerans_Agy99 ALGQRFLLLVDHTRYPPDGVSAEAVHEIRRIKARVESERLPRGADPNTHT
MLBr_01630|M.leprae_Br4923 DLGQRFLLMADKMRYPPDGVSAEAVREIRRMKARVEAERLPRGADPHTHT
MAV_2245|M.avium_104 ELGQRFLLMADKTRYPADGVSPEAVREIRRIKARVDAERLPRGADPNTHT
MAB_1921|M.abscessus_ATCC_1997 DLGLRFLHMIDKTRYPAGGIAQDAVREIRRIKARVDAERLPRGADPNTNT
** *** : *. *** .* : .:*:**:*:***:::*********:*:*
Mflv_2910|M.gilvum_PYR-GCK KLGRGGLADIEWTVQLLQLRFAHKIPALHTTSTLDTLNAIGAAELIAEGD
Mvan_3597|M.vanbaalenii_PYR-1 KLGRGGLADIEWTVQLLQLRFAHKIPALHTTSTLETLNAIGAAELIAEGD
MSMEG_4293|M.smegmatis_MC2_155 KLGRGGLADIEWTVQLLQLRYAHKVPALHNTSTLEALNAIGAAELVAEGD
TH_0214|M.thermoresistible__bu KLGRGGLADIEWTVQLLQLKHAHEVPALHNTSTLQTLDAIGAAELLPQSD
Mb2245c|M.bovis_AF2122/97 KLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAAD
Rv2221c|M.tuberculosis_H37Rv KLGRGGLADIEWTVQLLQLQHAHQVPALHNTSTLQSLDVIAAADLVPAAD
MMAR_3293|M.marinum_M KLGRGGLADIEWTVQLLQLQNAHEIEALHNTSTLESLDAIAEAKLVAEDE
MUL_1336|M.ulcerans_Agy99 KLGRGGLADIEWTVQLLQLQNAHEIEALHNTSTLESLDAIAEAKLVAEDE
MLBr_01630|M.leprae_Br4923 KLGRGGLADIEWTVQLMQLRHAHELPALHKTSTLESLDAIAAANLIPEAD
MAV_2245|M.avium_104 KLGRGGLADIEWTVQLLQLLHAHEVPALHNTSTLECLDAIAEAGLVPADE
MAB_1921|M.abscessus_ATCC_1997 KLGRGGLADVEWTVQLLQLRHAHEHQSLHSTSTLQTLRAAAEAGLIETED
*********:******:** **: :**.****: * . . * *: :
Mflv_2910|M.gilvum_PYR-GCK LELLREAWLTATKARNALVLVRGKPTDQLPGPGKLLNAVAVAAGWPD---
Mvan_3597|M.vanbaalenii_PYR-1 IELLREAWLTATRARNALVLVRGKPTDQLPGPGKLLTAVAVAAGWPG---
MSMEG_4293|M.smegmatis_MC2_155 VELLREAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVALAAGWGS---
TH_0214|M.thermoresistible__bu VELLREAWLLATRARNALVLVRGKPTDQLPGPGKLLNAVAVAAGWTADAA
Mb2245c|M.bovis_AF2122/97 VELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRN---
Rv2221c|M.tuberculosis_H37Rv VELLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWRN---
MMAR_3293|M.marinum_M VKLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWHN---
MUL_1336|M.ulcerans_Agy99 VKLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWHN---
MLBr_01630|M.leprae_Br4923 VDLLRQAWLTATRARNALVLVRGKTTDQLPGPGRQLNAVAVAAGWPS---
MAV_2245|M.avium_104 VDLLRQAWLTATRARNALVLVRGKPTDQLPGPGRQLNAVAVAAGWPT---
MAB_1921|M.abscessus_ATCC_1997 AELLRQAWLTATNARNALVLARGKPTDQLPGPGRLLNTVAAAAGWPD---
.***:*** **.*******.***.********: *.:** ****
Mflv_2910|M.gilvum_PYR-GCK -------GDGGEFLDNYLRVTRRAKAVVRKVFGG
Mvan_3597|M.vanbaalenii_PYR-1 -------GDGGEFLDNYLRVTRRAKAVVLRVFGG
MSMEG_4293|M.smegmatis_MC2_155 -------DDGGEFLDNYLRVTRRAKAVVRKIFGG
TH_0214|M.thermoresistible__bu ASPTSGSDDGGEFLNHYLRVTRRAKAVVRKVFG-
Mb2245c|M.bovis_AF2122/97 -------DDGGEFLDNYLRVTRRAKAVVRKVFGS
Rv2221c|M.tuberculosis_H37Rv -------DDGGEFLDNYLRVTRRAKAVVRKVFGS
MMAR_3293|M.marinum_M -------DDGGEFLDNYLRVTRRAKAVVRKVFGS
MUL_1336|M.ulcerans_Agy99 -------DDGGEFLDNYLRVTRRAKAVVRKVFGS
MLBr_01630|M.leprae_Br4923 -------DDGSEFLDNYLRVTRRAKTFVRKVFGS
MAV_2245|M.avium_104 -------DEGGEFLDNYLRVTRRAKAVVRKVFGS
MAB_1921|M.abscessus_ATCC_1997 -------NDGGEFLDNYLRVTRRAKAVVQRVFGE
.:*.***::*********:.* ::**