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VADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRD PTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLDRAERGFAYATDA PLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIP APARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASA TPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2189c | mraW | - | 100% (344) | S-adenosyl-methyltransferase MraW |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2980 | mraW | 1e-119 | 71.20% (316) | S-adenosyl-methyltransferase MraW |
| M. tuberculosis H37Rv | Rv2165c | mraW | 0.0 | 100.00% (344) | S-adenosyl-methyltransferase MraW |
| M. leprae Br4923 | MLBr_00906 | mraW | 1e-146 | 77.22% (338) | S-adenosyl-methyltransferase MraW |
| M. abscessus ATCC 19977 | MAB_1998 | - | 1e-115 | 66.67% (321) | S-adenosyl-methyltransferase MraW |
| M. marinum M | MMAR_3202 | mraW | 1e-146 | 76.88% (346) | methyltransferase |
| M. avium 104 | MAV_2328 | mraW | 1e-149 | 81.68% (333) | S-adenosyl-methyltransferase MraW |
| M. smegmatis MC2 155 | MSMEG_4235 | mraW | 1e-123 | 70.62% (320) | S-adenosyl-methyltransferase MraW |
| M. thermoresistible (build 8) | TH_0703 | - | 1e-125 | 70.40% (321) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_3510 | mraW | 1e-146 | 76.59% (346) | S-adenosyl-methyltransferase MraW |
| M. vanbaalenii PYR-1 | Mvan_3531 | mraW | 1e-124 | 73.10% (316) | S-adenosyl-methyltransferase MraW |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2980|M.gilvum_PYR-GCK ----------------MKPSATSSDLATGPQARAVWPLSEPALTYFPDVR
Mvan_3531|M.vanbaalenii_PYR-1 ----------------MKHSATFSDLATGPQARAVRPLPEPALTYFPDVR
MSMEG_4235|M.smegmatis_MC2_155 --------------------------------------------------
TH_0703|M.thermoresistible__bu --------------------------------------------------
Mb2189c|M.bovis_AF2122/97 --------------------------------------------------
Rv2165c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00906|M.leprae_Br4923 ----------------------MPSDRDHDAGIFAFF-------------
MAV_2328|M.avium_104 --------------------------------------------------
MMAR_3202|M.marinum_M --------------------------------------------------
MUL_3510|M.ulcerans_Agy99 MHVRAPWSLPEPTLAYFPNARFVPSDRDLGAGALRLVGEDCPAPTRGGVA
MAB_1998|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2980|M.gilvum_PYR-GCK FATSDRDLTAGAAPTPQSAAMVDDQPHVPVLLDRCVELLAPALTR-----
Mvan_3531|M.vanbaalenii_PYR-1 SAPSDRDLTAGAAPTSPSAAMVDDEPHIPVLLDRCVELLAPALTRTSTDG
MSMEG_4235|M.smegmatis_MC2_155 -MTND-----------------PDHGHIPVLLDRCVELLAPALTRTDPDG
TH_0703|M.thermoresistible__bu --------------------MSETYGHIPVLLDRCVQLLRPALTRHHPDG
Mb2189c|M.bovis_AF2122/97 MADPGS--------------GPTGFGHVPVLAQRCFELLTPALTRYYPDG
Rv2165c|M.tuberculosis_H37Rv MADPGS--------------GPTGFGHVPVLAQRCFELLTPALTRYYPDG
MLBr_00906|M.leprae_Br4923 GAVPRSDRCRQTRGGGEVVDGSSVFGHVPVFAQRCVTLLAPALTRHHADG
MAV_2328|M.avium_104 -MVDDS----------------PDFGHVPVLLERCVELLTPALTRRHPDG
MMAR_3202|M.marinum_M MADGPTEP------------GFNDFHHVPVLAQRCVELLRPALTRHHADG
MUL_3510|M.ulcerans_Agy99 VADGPTEP------------GFNDFHHVPVLAQRCVELLRPALTRHHADG
MAB_1998|M.abscessus_ATCC_1997 MSDNDS-----------------RYGHIPVMLDRCYELLAPALTADSTDG
*:**: :** ** ****
Mflv_2980|M.gilvum_PYR-GCK EGATLVDATLGAGGHSERFLTDFPGLRLIGLDRDPDALRIAGERLAPFAD
Mvan_3531|M.vanbaalenii_PYR-1 SGATLVDATLGAGGHSERFLTQFPALRLIGLDRDPDALHIAGDRLARFGD
MSMEG_4235|M.smegmatis_MC2_155 TEAVLVDATLGAGGHSERFLTDFPALRLIGLDRDPNALAIAGDRLAPFGD
TH_0703|M.thermoresistible__bu AGAVLLDATLGAGGHAERFLTDLPGLRVIGLDRDPDALAVAADQLARFGD
Mb2189c|M.bovis_AF2122/97 SQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFAD
Rv2165c|M.tuberculosis_H37Rv SQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFAD
MLBr_00906|M.leprae_Br4923 SNAILVDATLGVGGHAERFLTEFPGLRLIGLDRDPSALDIARTRLMRFAD
MAV_2328|M.avium_104 SGAVLLDATLGAGGHAERFLTDLPGLRLIALDRDPSALEIARERLARFAD
MMAR_3202|M.marinum_M SEAVLVDATIGAGGHAERFLTELPGLRLIGLDRDPSALEIVRTRLARFAD
MUL_3510|M.ulcerans_Agy99 SEAVLVDATIGAGGHAERFLTELPGLRLIGLDRDPSALEIVRTRLARFTD
MAB_1998|M.abscessus_ATCC_1997 SGAVLVDATLGAGGHTEHFLTMLPGLTVIGLDRDTNALDIARSRLAPFGT
* *:***:*.***:*:** :*.* :*.****. ** :. :* *
Mflv_2980|M.gilvum_PYR-GCK RITLVRTRYDGIADAVRDA---AGGSVDAILFDLGVSSMQLDRVERGFSY
Mvan_3531|M.vanbaalenii_PYR-1 RVTLVRTRYDGIAAAVAESNC-AATGVDAILFDLGVSSMQLDRVERGFAY
MSMEG_4235|M.smegmatis_MC2_155 RVTLVRTRYDGITSALAEA---GVRRIDGVLFDLGVSSMQLDQKQRGFSY
TH_0703|M.thermoresistible__bu RVQLVQTRFDGIP---------RDTEFDGVLFDLGVSSMQLDRPERGFSY
Mb2189c|M.bovis_AF2122/97 RLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLDRAERGFAY
Rv2165c|M.tuberculosis_H37Rv RLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLDRAERGFAY
MLBr_00906|M.leprae_Br4923 RVTLIHTRYDNLAVALNKFGYAAVESVDGVLFDLGVSSMQLDCAERGFSY
MAV_2328|M.avium_104 RITLVHTRYDGIAAALTESGYAATESVDGILFDLGVSSMQLDRPERGFAY
MMAR_3202|M.marinum_M RVTLVHTRYDGLASALTELGYGAAQSIDGALFDLGVSSMQLDQAERGFAY
MUL_3510|M.ulcerans_Agy99 RVTLVHTRYDGLASALTELGYGAAQSIDGALFDLGVSSMQLDQAERGFAY
MAB_1998|M.abscessus_ATCC_1997 RFVGVHTRYDGLADALDGLGYRTTSSVDGVLFDLGVSSMQLDQAERGFAY
*. ::**:* : .*. ************ :***:*
Mflv_2980|M.gilvum_PYR-GCK STDAPLDMRMDSGADLTAAQVLNSYDERALARVLREYGEEKFAGRIAAFI
Mvan_3531|M.vanbaalenii_PYR-1 SVDAPLDMRMDSGSDLTAAQVLNTYDEKALARVLRVYGEEKFAGRIAAQI
MSMEG_4235|M.smegmatis_MC2_155 SADAPLDMRMDPDALLTAAEIVNTYDAKTLTRILRDYGEERFAGRIADKI
TH_0703|M.thermoresistible__bu SADAPLDMRMDPTAELTAAEVVNTYDEKALTRVLREFGEERFASRIAAQI
Mb2189c|M.bovis_AF2122/97 ATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGI
Rv2165c|M.tuberculosis_H37Rv ATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGI
MLBr_00906|M.leprae_Br4923 AQDVPLDMRMDPWSPVSAADIVNNYDEAALADILRRYGEERFARRIAAHI
MAV_2328|M.avium_104 AQDAPLDMRMDPGSPLTAADILNTYDEAELADILHRYGEERFARRIAAQI
MMAR_3202|M.marinum_M SKDAPLDMRMNPQSALSAADIINTYDEAALADILHRYGEERFARRIAARI
MUL_3510|M.ulcerans_Agy99 SKDAPLDMRMNPQSALSGADIINTYDEAALADILHRYGEERFARRIAARI
MAB_1998|M.abscessus_ATCC_1997 SVDAPLDMRMNAQDELTAADILNTYSAVELSRVLSRFGEERFARRIADEI
: *.******:. ::.*:::*.*. *: :* :***:** *** *
Mflv_2980|M.gilvum_PYR-GCK VRRRAVTPFTTTGELVELLYDAIPAPARRTGGHPAKRTFQALRIEVNAEL
Mvan_3531|M.vanbaalenii_PYR-1 VRRRANTPFSTTGELVELLYQAIPAPARRTGGHPAKRTFQALRIEVNAEL
MSMEG_4235|M.smegmatis_MC2_155 VRRRAKQPFTTTSELVELLYEAIPAPARRTGGHPAKRTFQALRIAVNAEL
TH_0703|M.thermoresistible__bu VRRRARRPFRTTGELVELLYETIPAPARRTGGHPAKRTFQALRIEVNAEL
Mb2189c|M.bovis_AF2122/97 VRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDEL
Rv2165c|M.tuberculosis_H37Rv VRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDEL
MLBr_00906|M.leprae_Br4923 VRRRAHTPFTSTAELVALLYQAIPAPARRIGGHPAKRTFQALRIAVNDEL
MAV_2328|M.avium_104 VRRRAKEPFTSTADLVSLLYQAIPAPARRTGGHPAKRTFQALRIAVNDEL
MMAR_3202|M.marinum_M IRRRADKPFTTTAELVALLYEAIPAAARRTGGHPAKRTFQALRIAVNDEL
MUL_3510|M.ulcerans_Agy99 IRRRADRPFTTTAELVALLYEAIPAAARRTGGHPAKRTFQALRIAVNDEL
MAB_1998|M.abscessus_ATCC_1997 VRRRANEPFTRSGQLVELLYATIPAATRRTGGHPAKRTFQALRIAVNAEL
:**** ** :.:** *** :***.:** ************** ** **
Mflv_2980|M.gilvum_PYR-GCK ESLRSAIPAALQALRPHGRLAVMAYQSLEDRIVKTAFAAATASRTPPGLP
Mvan_3531|M.vanbaalenii_PYR-1 ESLRLAIPAALEVLRPHGRIAVMAYQSLEDRIVKTEFAAATASRTPPGLP
MSMEG_4235|M.smegmatis_MC2_155 DSLRAAIPAALAALRPGGRIVVMAYQSLEDRIVKQAFSTVTASRTPPGLP
TH_0703|M.thermoresistible__bu EALRAALPAAMAALRVGGRIAVMSYQSLEDRIVKAEFAAATASRTPPGLP
Mb2189c|M.bovis_AF2122/97 ESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLP
Rv2165c|M.tuberculosis_H37Rv ESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLP
MLBr_00906|M.leprae_Br4923 NSLSNVLPAALDALTVAGRLVVLAYQSLEDRIVKRVFADAVSSRTPAGLP
MAV_2328|M.avium_104 DTLRCALPAALDALAVDGRIVVLAYQSLEDRIVKRLFAQAVASRTPVDLP
MMAR_3202|M.marinum_M GSLRSAIPAAMDALAVGGRIVVMAYQSLEDRIVKRVFADAVASRTPMDLP
MUL_3510|M.ulcerans_Agy99 GSLRSAVPAAMDALAVGGRIVVMAYQSLEDRIVKRVFADAVASRTPVDLP
MAB_1998|M.abscessus_ATCC_1997 ESLATAIPAAMAALRPGGRVAVMAYQSLEDKIVKAEFAAATASRSPIDLP
:* .:***: .* **:.*::******:*** *: ..:* :* .**
Mflv_2980|M.gilvum_PYR-GCK VELPGHGPEFVALTRGAERADAEEIERNPRSAPVRLRAVEKVGGE-----
Mvan_3531|M.vanbaalenii_PYR-1 VELPGHGPRFVALTRGAERADAEEIERNPRSASVRLRALEKVGGQ-----
MSMEG_4235|M.smegmatis_MC2_155 MELPGHEPEFVAVTRGAERADEQEIERNPRSAPVRLRALEKVGGRGS---
TH_0703|M.thermoresistible__bu VELPGHEPEFRALTRGAERADDAEIERNPRSAPVRLRALEKVARRDN---
Mb2189c|M.bovis_AF2122/97 VELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQ
Rv2165c|M.tuberculosis_H37Rv VELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQ
MLBr_00906|M.leprae_Br4923 IELPGHGPRFRLLTRGAEHADAAEIECNPRSAAVRLRALQRTQHGVEPQQ
MAV_2328|M.avium_104 VELPGHEPRFRALTHGAGRADAAEIERNPRSAAVRLRALQRTQAPQ----
MMAR_3202|M.marinum_M VELPGHGPRFRSLTHGAERADAAEVERNPRSAPVRLRALERLELEALPRQ
MUL_3510|M.ulcerans_Agy99 VELPGHGPRFRSLTHGAERADAAEVEHNPRSAPVRLRALQRLELEALPRQ
MAB_1998|M.abscessus_ATCC_1997 VELPGDAPEFTAITRGAERANDEEIEVNPRSAPVRLRAVERVADRRNA--
:****. *.* :*:** :*. *:* ****:.*****:::
Mflv_2980|M.gilvum_PYR-GCK --------
Mvan_3531|M.vanbaalenii_PYR-1 --------
MSMEG_4235|M.smegmatis_MC2_155 --------
TH_0703|M.thermoresistible__bu --------
Mb2189c|M.bovis_AF2122/97 WATEKGDS
Rv2165c|M.tuberculosis_H37Rv WATEKGDS
MLBr_00906|M.leprae_Br4923 -PTRRGDS
MAV_2328|M.avium_104 -ATGKGD-
MMAR_3202|M.marinum_M -GTGKGES
MUL_3510|M.ulcerans_Agy99 -GTGKGES
MAB_1998|M.abscessus_ATCC_1997 --------