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MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDGCREEGIRLIDTRHEQTAAFAAEGWSKV TRVPGVAALTAGPGITNGMSAMAAAQQNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVARFAATAQS AENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGRPGALTELPAGPTPAGDALDRAAGLLSTAQ RPVIMAGTNVWWGHAEAALLRLVEERHIPVLMNGMARGVVPADHRLAFSRARSKALGEADVALIVGVPMD FRLGFGGVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLTATLSALAGSGGTDHQGWIEELATAETMARD LEKAELVDDRIPLHPMRVYAELAALLERDALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCLGSGPGY ALAAKLARPQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVIGNNGIWGLEKHPMEALYGYSVVAELRP GTRYDEVVRALGGHGELVSVPAELRPALERAFASGLPAVVNVLTDPSVAYPRRSNLA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1851 | ilvG | - | 100% (547) | hypothetical protein Mb1851 |
| M. bovis AF2122 / 97 | Mb0122c | oxcA | 6e-66 | 32.36% (547) | putative oxalyl-CoA decarboxylase |
| M. bovis AF2122 / 97 | Mb3028c | ilvB1 | 3e-39 | 27.61% (489) | acetolactate synthase 1 catalytic subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1796 | - | 2e-42 | 26.89% (543) | thiamine pyrophosphate enzyme, central region |
| M. tuberculosis H37Rv | Rv1820 | ilvG | 0.0 | 100.00% (547) | hypothetical protein Rv1820 |
| M. leprae Br4923 | MLBr_02083 | ilvG | 0.0 | 86.13% (548) | hypothetical protein MLBr_02083 |
| M. abscessus ATCC 19977 | MAB_3470c | - | 1e-41 | 28.60% (514) | acetolactate synthase |
| M. marinum M | MMAR_2697 | ilvG | 0.0 | 85.45% (550) | acetolactate synthase IlvG |
| M. avium 104 | MAV_2895 | - | 0.0 | 83.73% (547) | hypothetical protein MAV_2895 |
| M. smegmatis MC2 155 | MSMEG_5297 | - | 1e-60 | 30.63% (555) | putative oxalyl-CoA decarboxylase |
| M. thermoresistible (build 8) | TH_4403 | - | 1e-44 | 28.23% (542) | PUTATIVE thiamine pyrophosphate enzyme, central domain family |
| M. ulcerans Agy99 | MUL_3039 | ilvG | 0.0 | 85.27% (550) | hypothetical protein MUL_3039 |
| M. vanbaalenii PYR-1 | Mvan_4954 | - | 2e-40 | 26.01% (542) | thiamine pyrophosphate binding domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1851|M.bovis_AF2122/97 -------MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDG
Rv1820|M.tuberculosis_H37Rv -------MSTDTAPAQTMHAGRLIARRLKASGIDTVFTLSGGHLFSIYDG
MLBr_02083|M.leprae_Br4923 -------MSTDPVLTHSIHAGRLVVRRLKASGVDTVFTLSGGHLFSIYDG
MMAR_2697|M.marinum_M -------MSTDAAPVQTVHAGRLVARRLRASGVDTVFTLSGGHLFSLYDG
MUL_3039|M.ulcerans_Agy99 -------MSTDATPVQTVHAGRLVARRLRASGVDTVFTLSGGHLFSLYDG
MAV_2895|M.avium_104 ------MMTSDATSAPTLHAGRLVARRLRASGVDTVFTLSGGHLFSIYDG
Mflv_1796|M.gilvum_PYR-GCK ---------------MGVPVYKRILDLFEAEGVNTLFGIPDPNFVHMFTE
Mvan_4954|M.vanbaalenii_PYR-1 -------------MTMGIPVYKRILDLFEAEGVNTLFGIPDPNFVHMFTE
TH_4403|M.thermoresistible__bu ---------------MGVPVYKRILDLFEAEGINTLFGIPDPNFVHLFLE
MSMEG_5297|M.smegmatis_MC2_155 MNTAPLMTESVPGTSPVTDGAHVLVDALKLNGVETLYGVVGIPITDVARV
MAB_3470c|M.abscessus_ATCC_199 ----------------------------------MVFGIPGEENIRFIQA
:: : . .
Mb1851|M.bovis_AF2122/97 CREEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALTAGPGITNGMSAMA
Rv1820|M.tuberculosis_H37Rv CREEGIRLIDTRHEQTAAFAAEGWSKVTRVPGVAALTAGPGITNGMSAMA
MLBr_02083|M.leprae_Br4923 CRSESIRLIDTRHEQTAAFAAEGWSKVTRQPGVAVLTAGPGVTNGMSAMA
MMAR_2697|M.marinum_M CRDEGVRLIDTRHEQAAAFAAEGWSKVTRVPGVAALTAGPGVTNGMSAMA
MUL_3039|M.ulcerans_Agy99 CRDEGVRLVDTRHEQTAAFAAEGWSKVTRVPGVAALTAGPGVTNGMSAMA
MAV_2895|M.avium_104 CRDEGIRLIDTRHEQTATFAAEGWSKVTRLPGVAALTAGPGVTNGMSAMA
Mflv_1796|M.gilvum_PYR-GCK ADARGWSVVAPHHELSAGFMAEAASRMTGGPGLCIGTLGPGVANIAGAMM
Mvan_4954|M.vanbaalenii_PYR-1 ADARGWSVVAPHHELSAGFMAEAASRMTGNPGLCIGTLGPGVANIAGAMM
TH_4403|M.thermoresistible__bu AETRGWSVVAPHHEESAGFMAEAASRMTGRPGLCIGTLGPGLANIAGAMM
MSMEG_5297|M.smegmatis_MC2_155 AQAQGLRYIGFRHESDAGHAAAAAGFLTKKPGFCLTVSAPGFLNGLVALA
MAB_3470c|M.abscessus_ATCC_199 LAASDIRYILTRHEQGAAFMAEMYGRVTGRAGVVSATLGPGAINLQLGVA
. : :** * . * . :* .*. . .** * .:
Mb1851|M.bovis_AF2122/97 AAQQNQSPLVVLGG---RAPALRWGMGSLQEIDHVPFVAPVARFAATAQS
Rv1820|M.tuberculosis_H37Rv AAQQNQSPLVVLGG---RAPALRWGMGSLQEIDHVPFVAPVARFAATAQS
MLBr_02083|M.leprae_Br4923 AAQQNQSPLVVLGG---RAPALRWGMGSLQEIDHVPFVAPLARFAATAQS
MMAR_2697|M.marinum_M AAQQNQSPLVVLGG---RAPAGRWGMGSLQEIDHVPFVAPLARFAATAQS
MUL_3039|M.ulcerans_Agy99 AAQQNQSPLVVLGG---RAPAGRWGMGSLQEIDHVPFVAPLTRFAATAQS
MAV_2895|M.avium_104 AAQQNSSPLVVLGG---RAPAQRWAMGSLQEIDHVPFVAPLARFAATAQS
Mflv_1796|M.gilvum_PYR-GCK CALVENSPVIFLGGQRARVTERRVRRGRIQFVQQEGLFAPSVKYSSSIEY
Mvan_4954|M.vanbaalenii_PYR-1 CALVENSPVIFLGGQRARITERRVRRGRIQFVQQEGLFAPSVKYSSSIEY
TH_4403|M.thermoresistible__bu CAKVENSPVIFLGGQRARITERRVRRGRIQFVQQEGMLAPMVKFSSSIEY
MSMEG_5297|M.smegmatis_MC2_155 NATTNCFPMVQISGS-SDRHIVDLQRGDYEEMDQLAAAKPFVKAAFRVNR
MAB_3470c|M.abscessus_ATCC_199 DASTNSTPLVAIAA---QVGQDRAYKESHQYVDLVAMFRPITRWADGVPT
* : *:: :.. : :: * .: :
Mb1851|M.bovis_AF2122/97 AENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGR-PGALTELP
Rv1820|M.tuberculosis_H37Rv AENAGLLVDQALQAAVSAPSGVAFVDFPMDHAFSMSSDNGR-PGALTELP
MLBr_02083|M.leprae_Br4923 ADAAGRLVDEALQAAVVAPSGVGFVDFPMDYVFSMADDVGGGPGALANLP
MMAR_2697|M.marinum_M AEDAGRLVDQALRAAVGSRSGVAFVDFPMDHVFSMAEDDGR-PGVLTEQP
MUL_3039|M.ulcerans_Agy99 AEDAGLLVDQALRAAVGSHSGVAFVDFPMDHVFSMAQDDGR-PGVLTEQP
MAV_2895|M.avium_104 ADDAGRLVDDALRAAVGAPSGVGFVDFPMDHVFSMAEDDGR-PGALVDLP
Mflv_1796|M.gilvum_PYR-GCK ADQTDEIIREAIRRSMSGTPGPSYVEFPSHVILEELDVADPLPPERYRLV
Mvan_4954|M.vanbaalenii_PYR-1 ADQTDEIVHEAIRRAMSGTPGPAYIEFPSHVILDELNVGEAPEPSTYRLL
TH_4403|M.thermoresistible__bu AEQTDEIIREAIRRAMSGTPGPAYVEYPQHVILEELDVPDPLPPHRYRLV
MSMEG_5297|M.smegmatis_MC2_155 AADIGLAVARAIRTASSGRPGGVYLDIPAAVLGEVIDAGAAAASLRTVVD
MAB_3470c|M.abscessus_ATCC_199 ARAIPEMFRKAFKLAETERPAAVFLAVPENIDADGANYELNPLPRNVVHP
* . *:: : .. :: * . .
Mb1851|M.bovis_AF2122/97 AG---PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEER
Rv1820|M.tuberculosis_H37Rv AG---PTPAGDALDRAAGLLSTAQRPVIMAGTNVWWGHAEAALLRLVEER
MLBr_02083|M.leprae_Br4923 VA---PAANPEALDRAAGLLAAAHRPVIMAGTNVWWGHAEAALLRLAEEC
MMAR_2697|M.marinum_M AAAQHPAPNGREIDRAAELLSRAHRPVIMAGTNVWWGHGERALLRLAEER
MUL_3039|M.ulcerans_Agy99 AAAQHPAPNGREIDRAAELLSRAQRPVIMAGTNVWWGHGERALLRLAEER
MAV_2895|M.avium_104 RE---PEPDGAALGRAAGLLSGAKRPVIMAGTNVWWGHGEAALLRLAEEL
Mflv_1796|M.gilvum_PYR-GCK NQG----AGEREIAEAARLIRAAERPILLVGHGVHTSRTQQQVRELAELM
Mvan_4954|M.vanbaalenii_PYR-1 NQG----AGAREVAEAVELIRQAERPILLVGHGVHTSRTQEQVRELAELM
TH_4403|M.thermoresistible__bu DQR----AGAAEIAEAVRLIRAAEHPILLVGHAVHTSRTQQPVRELAELM
MSMEG_5297|M.smegmatis_MC2_155 AAP-EQLPPPRAVDRAVALLAAARRPLVVLGKGAAYAQADKTIRNFLEST
MAB_3470c|M.abscessus_ATCC_199 EAP-----MAGQVQRAVDILRRAHRPVLLAGHGAARGGATAALIRFSEEL
: .*. :: *.:*::: * . . : .: *
Mb1851|M.bovis_AF2122/97 HIPVLMNGMARGVVP----ADHRLAFSRA-------RSKALGEADVALIV
Rv1820|M.tuberculosis_H37Rv HIPVLMNGMARGVVP----ADHRLAFSRA-------RSKALGEADVALIV
MLBr_02083|M.leprae_Br4923 QIPVLMNGMARGVVP----ADHPLAFSRA-------RGKALGEADVALVV
MMAR_2697|M.marinum_M QIPVLMNGMARGVVP----ADHPLAFSRA-------RSKALGEADVALIV
MUL_3039|M.ulcerans_Agy99 QIPVLMNGMARGVVP----ADHPLAFSRA-------RSKALGEADVALIV
MAV_2895|M.avium_104 AIPVLMNGMARGAVP----ADHPLAFSRV-------RGKALGEADVALIV
Mflv_1796|M.gilvum_PYR-GCK ACPVIQTSGGTSFIPGLQDRTFPYLFSPA-------ANEAVEQSDLCVAL
Mvan_4954|M.vanbaalenii_PYR-1 ACPVIQTSGGTSFIPGLEDRTFPYLFSPA-------ANEAVEQSDLCVAL
TH_4403|M.thermoresistible__bu GCPVIQTSGGTSFIPGIEDRTFPYGFSPA-------AIEAVRTSDLCVAL
MSMEG_5297|M.smegmatis_MC2_155 GLPFLPMSMAKGLLP----DTHPQSVASA-------RSMALRDADVVLLV
MAB_3470c|M.abscessus_ATCC_199 GVPVANTFHGKGAMP----DDHPNSMGTVGFMRRDYANFGFEHADVIVAV
*. . . :* . .. . .. :*: : :
Mb1851|M.bovis_AF2122/97 GVPMDFRLGFG-----GVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLT
Rv1820|M.tuberculosis_H37Rv GVPMDFRLGFG-----GVFGSTTQLIVADRVEPAREHPRPVAAGLYGDLT
MLBr_02083|M.leprae_Br4923 GVPMDFRLGFG-----KVFGSQTQLVVADRAEPDRDYPRPVAAGLYGDLP
MMAR_2697|M.marinum_M GVPMDFRLGFG-----GVFGPQTQLIVVDRAEPERQHPRPIAAGLYGDLS
MUL_3039|M.ulcerans_Agy99 GVPMDFRLGFG-----GVFGPQTQLIVVDRAEPERQHPRPIAAGLYGDLS
MAV_2895|M.avium_104 GVPMDFRLGFG-----AVFGPHTRLIVADRVAPERKHPRPVEAQLYGDLM
Mflv_1796|M.gilvum_PYR-GCK GTELGEPMHYGRTQHWAGNDANRKWILVEQDPTAIGVNRPIDVPLVGDLR
Mvan_4954|M.vanbaalenii_PYR-1 GTELGEPMHYGRTQHWAGNDANRKWVYVEQDPTAIGVNRSFDVPLVGDLR
TH_4403|M.thermoresistible__bu GTELGEPVHFGRHRHWVDNEANRKWVYVEQDPAAIGVNRPIDVPLIGDLR
MSMEG_5297|M.smegmatis_MC2_155 GARLNWLLGHGEP---PQFSRDVKFIQVDIDPGELDSNAPIAAPLVGDIG
MAB_3470c|M.abscessus_ATCC_199 GYELQEFDPVR-----INPHGDKQIIHLHRFPAEVDAHYSVSVGIIGDIS
* : : : . .. . : **:
Mb1851|M.bovis_AF2122/97 ATLSALAGSGGTDHQG---WIEELATAETMARDLEKAELVDDRIPLHPMR
Rv1820|M.tuberculosis_H37Rv ATLSALAGSGGTDHQG---WIEELATAETMARDLEKAELVDDRIPLHPMR
MLBr_02083|M.leprae_Br4923 AILSALAGVGGTDSQD---WIRALRTAETATRDLEKAELDDDRLPLHPMR
MMAR_2697|M.marinum_M QILAALTGPDAGDHQS---WIRELRDTETEAREREKTELAEDRIPLHPMR
MUL_3039|M.ulcerans_Agy99 QILAALTGPDAGDHQS---WIRELRDTETEAREREKTELAEDRIPLHPMR
MAV_2895|M.avium_104 TILAALATAGGGDHRD---WIDELRTAETAARAAEQAELADDRVPLHPMR
Mflv_1796|M.gilvum_PYR-GCK GVVPQLVDALRDTPRAPSANLDSLVKADAAELARVAEEAPSGRAPVHPAR
Mvan_4954|M.vanbaalenii_PYR-1 GVVPQLVEALRDTTRAPSANLETLVDADAAELARVAEEAPSGRTPVHPAR
TH_4403|M.thermoresistible__bu GVVPQLVEALREQPRQPSPDLDRWIRQDAERLAELAETAPTGRKPVHPAR
MSMEG_5297|M.smegmatis_MC2_155 SVIEALAERAQFIDAP-APWREQLAERKARNAESMAKRLAADPRPMRFHG
MAB_3470c|M.abscessus_ATCC_199 ASVNALTDALAGHRFD-----CAAAPGSALLAEEFTRGQQDSRFPMAPQR
: *. .: . *:
Mb1851|M.bovis_AF2122/97 VYAELAALLER---DALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCL
Rv1820|M.tuberculosis_H37Rv VYAELAALLER---DALVVIDAGDFGSYAGRMIDSYLPGCWLDSGPFGCL
MLBr_02083|M.leprae_Br4923 VYAELASLLDR---DAIVVIDAGDFGSYAGRVIDSYLPGCWLDSGPFGCL
MMAR_2697|M.marinum_M VYAELAPLLDR---DAIVVIDAGDFGSYAGRVIDSYQPGCWLDSGPFGCL
MUL_3039|M.ulcerans_Agy99 VYAELAPLLDR---DAIVVIDAGDFGSYAGRVIDSYQPGCWLDSGPFGCL
MAV_2895|M.avium_104 VYAELAPMLDR---DAIVVIDAGDFGSYAGRVIDSYRPGCWLDSGPFGCL
Mflv_1796|M.gilvum_PYR-GCK YVVEATKAFNEHTEDGILVRDGGATVIFQWTYSQVKPRDVIWNQN-FGHL
Mvan_4954|M.vanbaalenii_PYR-1 FVVEATKAFNDYAQDGILVRDGGATVIFQWTYSQAKPRDVIWNQN-FGHL
TH_4403|M.thermoresistible__bu FVVEATKALPD---DAILVRDGGATVIFQWTYSQAKPRDVIWNQN-FGHL
MSMEG_5297|M.smegmatis_MC2_155 ALRAIRDVLRDRP-DVYVVNEGANALDLARNVIDMAVPRHRLDSGTWGVM
MAB_3470c|M.abscessus_ATCC_199 IVADIRAALGR---SDVVLVDTGATKMWMARLYPTYEPNTCLVSNGLSTM
: . :: : . .. . :
Mb1851|M.bovis_AF2122/97 GSGPGYALAAKLAR-PQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVI
Rv1820|M.tuberculosis_H37Rv GSGPGYALAAKLAR-PQRQVVLLQGDGAFGFSGMEWDTLVRHNVAVVSVI
MLBr_02083|M.leprae_Br4923 GSGPGYALAAKLAR-PNRQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVI
MMAR_2697|M.marinum_M GSGPGYALAAKLAR-PERQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVV
MUL_3039|M.ulcerans_Agy99 GSGPGCALAAKLAR-PERQVVLLQGDGAFGFSGMEWDTLVRHNVPVVSVV
MAV_2895|M.avium_104 GSGPGYALAAKLAR-PERQVVLLQGDGAFGFSGMEWDTLVRHRVPVVSVI
Mflv_1796|M.gilvum_PYR-GCK GTGLPYAVGASVAEGRKRPVMLLTSDSAFLFHIAELETAVRENLPLVCVV
Mvan_4954|M.vanbaalenii_PYR-1 GTGLPYAVGASVAEGRTRPVMLLTSDSAFLFHIAELETAARENVPLVCVV
TH_4403|M.thermoresistible__bu GTGLPYAVGASVAEGGKRPVMLLTSDSAFLFHIAELETAARQNLPLVCVV
MSMEG_5297|M.smegmatis_MC2_155 GVGMGYAIAAAVEG--SGPVVAIEGDSAFGFSAMELETICRYRLPVVVVV
MAB_3470c|M.abscessus_ATCC_199 GFALPGALGVKLAR-PDTKVLAVAGDGAFLMNSQEIETAVRERIPLVVLI
* . *:.. : *: : .*.** : * :* * .:.:* ::
Mb1851|M.bovis_AF2122/97 GNNGIWGLEKHPMEALYG---YSVVAELRPGTRYDEVVRALGGHGELVSV
Rv1820|M.tuberculosis_H37Rv GNNGIWGLEKHPMEALYG---YSVVAELRPGTRYDEVVRALGGHGELVSV
MLBr_02083|M.leprae_Br4923 GNNGIWGLEKHPMEALYG---YSVVAELRPGTRYDEVVRALGGHGELVSV
MMAR_2697|M.marinum_M GNNGIWGLEKHPMEALYG---YSVVAELRPGTRYDEVVRALGGHGELVAA
MUL_3039|M.ulcerans_Agy99 GNNGIWGLEKHPMEALYG---YSVVAELRPGTRYDEVVRALGGHGELVAA
MAV_2895|M.avium_104 GNNGIWALEKHPMEQLYG---YSVVAELRPGTRYDEVARALGGHGELVAA
Mflv_1796|M.gilvum_PYR-GCK GVDHQWGLEVGVYKRTFEQPSPQPGVHWSKDVRMDKIAEGFGCHGEYVEK
Mvan_4954|M.vanbaalenii_PYR-1 GVDHQWGLEVGVYKRTFEQPSPQPGVHWSKDVRMDKIAEGFGCHGEYVEK
TH_4403|M.thermoresistible__bu GVDHAWGLEVGVYKRTFEQPSPQPGVHWSKNVRFDKIAEGLDCHGEFVDS
MSMEG_5297|M.smegmatis_MC2_155 LNNGGVYRGDGHNPASDD----PSPTTLMPAARHDRLIEAFGGTGHHVTT
MAB_3470c|M.abscessus_ATCC_199 WEDGGYGLIEWKMDLELG----EHHHVSFTNPDIVSYAESFGAKGYRITA
: ..:. * :
Mb1851|M.bovis_AF2122/97 PAELRPALERAFASGLPAVVNVLTDPSVAYPR--RSNLA-----------
Rv1820|M.tuberculosis_H37Rv PAELRPALERAFASGLPAVVNVLTDPSVAYPR--RSNLA-----------
MLBr_02083|M.leprae_Br4923 PGELRPALERAFVTGLPSVVNVLTDPSVAYPR--RSNLA-----------
MMAR_2697|M.marinum_M PAQLRPALERAFASGLPAVVNVLTDPSVAYPR--RSNLA-----------
MUL_3039|M.ulcerans_Agy99 PAELRPALERAFASGLPAVVNVLTDSSVAYPR--RSNLA-----------
MAV_2895|M.avium_104 PGELRPALERAFASGLPAVVNVLTDPTVAYPR--RSNLA-----------
Mflv_1796|M.gilvum_PYR-GCK EDEIGPAIQRAFASGKTAVVHVCIDPKANSEE--MPKYDRFRTWYAEGTQ
Mvan_4954|M.vanbaalenii_PYR-1 EDEIGPAIQRAYASGRTAVVHVCIDPKANSEE--MPKYDRFRTWYAEGTQ
TH_4403|M.thermoresistible__bu EEEIGPAIKRAYASGRTAVVHVAIDPKANSEE--MPSYDEFRTWYAEGQQ
MSMEG_5297|M.smegmatis_MC2_155 PAELGAALTEALASGGPALIDCVIDPADGTESGHLTQLNPAVVGHHPATN
MAB_3470c|M.abscessus_ATCC_199 ADQLLPTLQAALDDGGVSLIACPVDYSENLRLTDRLGQLDATL-------
:: .:: * * ::: *