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VSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEAMVLSTCNRVEVYAVVDAFHGGLSVIG QVLAEHSGMSMGELTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQVRRAYAVAESNRTVGRVLHE LAQRALSVGKRVHSETAIDAAGASVVSVALGMAERKLGSLAGTTAVVIGAGAMGALSAVHLTRAGVGHIQ VLNRSLSRAQRLARRIRESGVPAEALALDRLANVLADADVVVSCTGAVRPVVSLADVHHALAAARRDEAT RPLVICDLGMPRDVDPAVARLPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAAEVASYLVGQRMAEVTP TVTALRQRAAEVVEAELLRLDNRLPGLQSVQREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYAEAL RELFELDQTAVDAVATAGELPVVPSGFDAESRRGGGDMQSSPKRSPSN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0521 | hemA | - | 100% (468) | glutamyl-tRNA reductase |
| M. bovis AF2122 / 97 | Mb2971c | pks1 | 6e-06 | 25.66% (304) | polyketide synthase PKS1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0067 | hemA | 0.0 | 76.78% (435) | glutamyl-tRNA reductase |
| M. tuberculosis H37Rv | Rv0509 | hemA | 0.0 | 100.00% (468) | glutamyl-tRNA reductase |
| M. leprae Br4923 | MLBr_02422 | hemA | 0.0 | 82.51% (463) | glutamyl-tRNA reductase |
| M. abscessus ATCC 19977 | MAB_3993c | hemA | 1e-178 | 73.98% (442) | glutamyl-tRNA reductase |
| M. marinum M | MMAR_0842 | hemA | 0.0 | 85.03% (461) | glutamyl-tRNA reductase HemA |
| M. avium 104 | MAV_4640 | hemA | 0.0 | 86.50% (452) | glutamyl-tRNA reductase |
| M. smegmatis MC2 155 | MSMEG_0952 | hemA | 0.0 | 77.95% (449) | glutamyl-tRNA reductase |
| M. thermoresistible (build 8) | TH_0269 | hemA | 0.0 | 79.01% (443) | PROBABLE GLUTAMYL-TRNA REDUCTASE HEMA (GLUTR) |
| M. ulcerans Agy99 | MUL_4598 | hemA | 0.0 | 84.82% (461) | glutamyl-tRNA reductase |
| M. vanbaalenii PYR-1 | Mvan_0844 | hemA | 0.0 | 76.55% (435) | glutamyl-tRNA reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0067|M.gilvum_PYR-GCK MSVLLFGVSHRSAPVSVLEQLSTDESDQAKIIAEVLRSSLVTEAMVLSTC
Mvan_0844|M.vanbaalenii_PYR-1 MSVLLFGVSHRSAPVSVLEQLSVDDSDQAKLIDQVLQSSLVTEAMVLSTC
TH_0269|M.thermoresistible__bu VSVLLFGVSHRSAPVSVLEQLSTEESEQAKIIDRVLESSLVTEAMVLSTC
MSMEG_0952|M.smegmatis_MC2_155 MSVLLFGVSHRSAPVSVLEQLSTNEAEQAKIIDQVLQSSLVTEAMVLSTC
Mb0521|M.bovis_AF2122/97 MSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEAMVLSTC
Rv0509|M.tuberculosis_H37Rv MSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEAMVLSTC
MAV_4640|M.avium_104 MSVLLFGVSHRSAPVSVLEQLSIDESDHGKIVDRVLQSPLVTEAMVLSTC
MLBr_02422|M.leprae_Br4923 MSILLFGVSHRSAPVSVLEQLSLDRSDQIKIVDRVLQSPLVTEAMVLSTC
MMAR_0842|M.marinum_M MSILLFGVSHRSAPVSVLEQLSIDESEQVKIVDRVLQSPLVTEAMVLSTC
MUL_4598|M.ulcerans_Agy99 MSILLFGVSHRSAPVSVLEQLSIDESEQVKIVDRVLQSPLVTEAMVLSTC
MAB_3993c|M.abscessus_ATCC_199 MSVLLFGASHRSAPVPVLEKLAIGEADQPKIIEHILQSPLVTEVMVLSTC
:*:****.******* ***:*: ::: *:: .:* *.****.******
Mflv_0067|M.gilvum_PYR-GCK NRVEIYAVVEAFHGGLSVIGQVLSDHSGMSLQDLTKYAYVRYAEAAVEHL
Mvan_0844|M.vanbaalenii_PYR-1 NRVEIYAVVEAFHGGLSVIGQVLSEHSGMSLQDLTKHAYVRYAEAAVEHL
TH_0269|M.thermoresistible__bu NRVEIYAVVDAFHGGLSVIGQVLSEHSGMPLNDLTKYAYVRYAEAAVEHL
MSMEG_0952|M.smegmatis_MC2_155 NRVEVYAVVEAFHGGLSVIGQVLAERSGMSLNDLTKYAYVRYAEAAVEHL
Mb0521|M.bovis_AF2122/97 NRVEVYAVVDAFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHL
Rv0509|M.tuberculosis_H37Rv NRVEVYAVVDAFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHL
MAV_4640|M.avium_104 NRVEVYAVVDAFHGGLAVIGQVLSDHSGMSMSDLTKYAYVRYSEAAVEHL
MLBr_02422|M.leprae_Br4923 NRVEVYAVVEAFHAGLSVIGQVLSEYSAMSIGDLTKYAYVRYSEAAVEHL
MMAR_0842|M.marinum_M NRVEVYAVVEAFHGGLSAIGQVLSDHSGMSMGELTKHAYVRYSEAAVEHL
MUL_4598|M.ulcerans_Agy99 NRVEVYAVVEAFHGGLSAIGQVLSDHSGMSMGELTKHAYVRYSEAAVEHL
MAB_3993c|M.abscessus_ATCC_199 NRVEVYAVVEAFHGGLTVIGEAIARHAGMGMNELTKYAYVRYSEAAVEHL
****:****:***.**:.**:.:: :.* : :***:*****:*******
Mflv_0067|M.gilvum_PYR-GCK FAVASGLDSAVVGEQQVLGQVRRAYASAESNHTVGRTLHELSQRALAVGK
Mvan_0844|M.vanbaalenii_PYR-1 FSVAGGLDSAVIGEQQVLGQVRRAYASAEANHTVGRTLHELSQRALAVGK
TH_0269|M.thermoresistible__bu FAVASGLDSAVVGEQQVLGQVRRAYAAAEANRSVGRTLHELAQRALSVGK
MSMEG_0952|M.smegmatis_MC2_155 FAVTSGLDSAVIGEQQVLGQVRRAYATAEANRTVGRTLHELAQRALSVGK
Mb0521|M.bovis_AF2122/97 FAVASGLDSAVIGEQQVLGQVRRAYAVAESNRTVGRVLHELAQRALSVGK
Rv0509|M.tuberculosis_H37Rv FAVASGLDSAVIGEQQVLGQVRRAYAVAESNRTVGRVLHELAQRALSVGK
MAV_4640|M.avium_104 FAVASGLDSAVIGEQQVLGQVRRAYATAETNRTVGRVLHELAQRALSVGK
MLBr_02422|M.leprae_Br4923 FTVASGLDSAVVGEQQVLGQVRRAYAAAEANRTVGQVLHEVAQRALSVGK
MMAR_0842|M.marinum_M FAVASGLDSAVVGEQQVLGQVRRSYSAAEANRTVGRVLHELAQRALSVGK
MUL_4598|M.ulcerans_Agy99 FAVASGLDSAVVGEQQVLGQVRRSYSAAEANRTVGRVLHELAQRTLSVGK
MAB_3993c|M.abscessus_ATCC_199 FAVASGLDSMVVGEQQVLGQVRNAYATAESHQAVGRVLHELSQSALRVGK
*:*:.**** *:**********.:*: **::::**:.***::* :* ***
Mflv_0067|M.gilvum_PYR-GCK RVHSETGIDRAGASVVSVALDVAEKKVG-PLAGRSAVVVGAGSMGALAAT
Mvan_0844|M.vanbaalenii_PYR-1 RVHSETGIDAAGASVVSVALDTAEKKVG-SLAGRSAVLVGAGSMGALAAK
TH_0269|M.thermoresistible__bu RVHSETGIDAAGASVVSVALDIAGRTLG-SLAARNALIIGAGSMGALTAK
MSMEG_0952|M.smegmatis_MC2_155 RVHSETGIDAAGASVVSVALGMAETKLSGGLGGRTAAVVGAGAMGALAGA
Mb0521|M.bovis_AF2122/97 RVHSETAIDAAGASVVSVALGMAERKLG-SLAGTTAVVIGAGAMGALSAV
Rv0509|M.tuberculosis_H37Rv RVHSETAIDAAGASVVSVALGMAERKLG-SLAGTTAVVIGAGAMGALSAV
MAV_4640|M.avium_104 RVHSETAIDAAGASVVSVALDMADRRLG-GLAGKTAVLVGAGAMGALAAA
MLBr_02422|M.leprae_Br4923 RVHSETAIDAAGVSVVSVALGIAGRTLG-GLAGRIAVVIGAGAMGALSSS
MMAR_0842|M.marinum_M RVHSETSIDAAGASVVSVALGIAERKLG-GLGAKTAVVIGAGSMGALSSA
MUL_4598|M.ulcerans_Agy99 RVHSETSIDAAGASVVSVALGIAERKLG-GLGAKTAVVIGAGSMGALSSA
MAB_3993c|M.abscessus_ATCC_199 RVHSETGIDAAGASVVSVALNLADNKLD-GLPGRTAAVVGAGSMGSLATA
******.** **.*******. * :. * . * ::***:**:*:
Mflv_0067|M.gilvum_PYR-GCK QLARAGIERIHVVNRSLPRGKRLAENIRGYGIAAEAYPFDHLPPLLTDAD
Mvan_0844|M.vanbaalenii_PYR-1 QLMRAGVERIHVVNRTLPRAAKLAENVRSYGITAEAFPFDHLPPLLTDAD
TH_0269|M.thermoresistible__bu HLVAAGVERIQVVNRSLPRAKRLAHNITEQGVAAEALTLDHICAALADAD
MSMEG_0952|M.smegmatis_MC2_155 HLVRAGIERVHVVNRSLPRAERLAKNLTEQGVVADAVGLDDIARALVDAD
Mb0521|M.bovis_AF2122/97 HLTRAGVGHIQVLNRSLSRAQRLARRIRESGVPAEALALDRLANVLADAD
Rv0509|M.tuberculosis_H37Rv HLTRAGVGHIQVLNRSLSRAQRLARRIRESGVPAEALALDRLANVLADAD
MAV_4640|M.avium_104 HLSRAGIGQVHVLNRSLSRAQRLVRKIRETGVRADALPLEHLADALAGAD
MLBr_02422|M.leprae_Br4923 YLTQANVGRIHVLNRSLSRARRLAGKIGESGVPADVWTLNHLDEALADAD
MMAR_0842|M.marinum_M HLTRAGIGKVHVLNRSLARAQRLAGKIRQSGVLAEARTLDRLAEVLTDAD
MUL_4598|M.ulcerans_Agy99 HLTRAGIGKVHVLNRSLARAQRLAGKIRQSGVLAEARTLDRLAEVLTDAD
MAB_3993c|M.abscessus_ATCC_199 QLIRAGIDNLWVVNRSAERARRLAATAREAGVNAQAITLDNLDQALAQAD
* *.: .: *:**: *. :*. *: *:. :: : *. **
Mflv_0067|M.gilvum_PYR-GCK IVVSCTGAVRPVVSLADVHRGLAH------VREPKDLVICDLGMPRDVDA
Mvan_0844|M.vanbaalenii_PYR-1 IVVTCTGAVRPVVSLADVHRGLAH------VREPKELVICDLGMPRDVDP
TH_0269|M.thermoresistible__bu VVVSSTGAVSPVVSLADAHRALAG------RSEDRELVICDLGMPRDVDA
MSMEG_0952|M.smegmatis_MC2_155 VVLSSTGAVRPVVSLADVHYALAQRTL---AGAEHQMVVCDLGMPRDVDP
Mb0521|M.bovis_AF2122/97 VVVSCTGAVRPVVSLADVHHALAAARR---DEATRPLVICDLGMPRDVDP
Rv0509|M.tuberculosis_H37Rv VVVSCTGAVRPVVSLADVHHALAAARR---DEATRPLVICDLGMPRDVDP
MAV_4640|M.avium_104 VVVSCTGAVSPVVSLADVHHALAAAGRSAADETAHPLVICDLGMPRDVDP
MLBr_02422|M.leprae_Br4923 LVVSCTGAVSPVVSLADVHHALAAMRR---DETTRPLVICDLGMPRDVDP
MMAR_0842|M.marinum_M VVVSCTGAVAPVVSLADVHHALATARR---DETTRPLVICDLGMPRDVDP
MUL_4598|M.ulcerans_Agy99 AVVSCTGAVAPVVSLADVHHALATARR---DETTRPLVICDLGMPRDVDP
MAB_3993c|M.abscessus_ATCC_199 VVVSCTGAVRPVISLADVHHALEG---------GRQLVFCDLGMPRDVDP
*::.**** **:****.* .* : :*.**********.
Mflv_0067|M.gilvum_PYR-GCK AVAGLPGVFVIDMDRILREPTAKTATSDADAARSIVATEVANYLAGQRVA
Mvan_0844|M.vanbaalenii_PYR-1 AVAGLPGVFVVDMERILREPTARAAATDADAARTIVAAEVAKYLAGQRMA
TH_0269|M.thermoresistible__bu AVAGLPAVHVVDMERIQREPSARAAASDAEAARAIVAAEVARYLAGQRMA
MSMEG_0952|M.smegmatis_MC2_155 AVSGLPGVWVVDMDRIQREPSARAAAVDAEAARNIVAAEVANYLAGQRMA
Mb0521|M.bovis_AF2122/97 AVARLPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAAEVASYLVGQRMA
Rv0509|M.tuberculosis_H37Rv AVARLPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAAEVASYLVGQRMA
MAV_4640|M.avium_104 AVAGLPGVWVVDVDRVQHEPSAHAAAADVDAARTIVATEVAAYLAGQRMA
MLBr_02422|M.leprae_Br4923 AVAKLPGVWVVDVEGVQREPSARASAADVDAARRIVAAEVATYLTRQRMA
MMAR_0842|M.marinum_M AVAGLPGVWLIDVERVQREPSAHAASADVAAARHIVAAEVAGYLAGQRMA
MUL_4598|M.ulcerans_Agy99 AVAGLPGVWLIDVERVQREPSAHAASADVAAARHIVAAEVAGYLAGQRMA
MAB_3993c|M.abscessus_ATCC_199 TVAGLPGVVVVDMERIQREPTARAAANDAGAARQIVNDEVARYLTGERMA
:*: ** * ::*:: : :**:*:::: *. *** ** *** **. :*:*
Mflv_0067|M.gilvum_PYR-GCK EVTPTVTALRQRAADVVEAELLRLDNRLPGLDSSHRDEVANTVRRVVDKL
Mvan_0844|M.vanbaalenii_PYR-1 EVTPTVTALRQRAADVVEAELLRLDNRLPGLDAAHRDEVANTVRRVVDKL
TH_0269|M.thermoresistible__bu EVTPTVTALRKRAADVVEAELLRLDNRLPELDAAHRDEVARTVRRVVDKL
MSMEG_0952|M.smegmatis_MC2_155 EVTPTVTALRQRAADVVEAELLRLDNRLPGLDAAHRDEVAKTVRRVVDKL
Mb0521|M.bovis_AF2122/97 EVTPTVTALRQRAAEVVEAELLRLDNRLPGLQSVQREEVARTVRRVVDKL
Rv0509|M.tuberculosis_H37Rv EVTPTVTALRQRAAEVVEAELLRLDNRLPGLQSVQREEVARTVRRVVDKL
MAV_4640|M.avium_104 EVTPTVTALRQRAADVVEAELLRLDNRLPGLDSAHREEVARTVRRVVDKL
MLBr_02422|M.leprae_Br4923 EVAPTVTALRQRAADVVEAELLRLDHRLPGLESAQREEVARTVRRVVDKL
MMAR_0842|M.marinum_M EVTPTVTALRQRAADVVEAELLRLDNRLPGLDSAERDEVARTVRRVVDKL
MUL_4598|M.ulcerans_Agy99 EVTPTVTALRQRAADVVEAELLRLDNRLPGLDSAERDEVARTVRRVVDKL
MAB_3993c|M.abscessus_ATCC_199 EVTPTVTALRQRAAEVVEAELLRLDGRLPGLAGAERDEVAKTVRRVVDKL
**:*******:***:********** *** * . .*:***.*********
Mflv_0067|M.gilvum_PYR-GCK LHAPTVRVKQLASAPGGDSYAEALRELFELDQHAVDAVA-GSELGAVSG-
Mvan_0844|M.vanbaalenii_PYR-1 LHAPTVRVKQLAGAPGGDSYAEALRELFELDQHAVDAVA-GTELGPLAGG
TH_0269|M.thermoresistible__bu LHAPTVRVKQLASAPGGDSYAEALRELFELDQQAVDAVA-GSELKPTVSG
MSMEG_0952|M.smegmatis_MC2_155 LHAPTVRVKQLASAPGGDSYAEALRELFELDPQAVEAVA-ASELPLITT-
Mb0521|M.bovis_AF2122/97 LHAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVATAGELPVVPSG
Rv0509|M.tuberculosis_H37Rv LHAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVATAGELPVVPSG
MAV_4640|M.avium_104 LHAPTVRIKQLASAPGGDSYAEALRELFELDQTAVDAVA-AGELPVIATG
MLBr_02422|M.leprae_Br4923 LHAPTVRIKQLASAPGGDSYTEALRELFELDQTAVDAVATAGELPVMVSG
MMAR_0842|M.marinum_M LHAPTVRIKQLASAPGGDSYAEALRELFQLDQTAVDAVATAGELPVFSSG
MUL_4598|M.ulcerans_Agy99 LHAPTVRIKQLASAPGGDSYAEALRELFQLDQTAVDAVATAGELPVFSSG
MAB_3993c|M.abscessus_ATCC_199 LHAPTVRVKQLASAPGGDSYAEALRELFELDPHTVEAVATAGELPLATKE
*******:****.*******:*******:** :*:*** . **
Mflv_0067|M.gilvum_PYR-GCK DELAAP--AIDLDLTE-----------------------------
Mvan_0844|M.vanbaalenii_PYR-1 DELGSL--AIDLDMTE-----------------------------
TH_0269|M.thermoresistible__bu DINTAVGDALDTALSDAARATVPPEIRAPEIKAPDIRSVTTELED
MSMEG_0952|M.smegmatis_MC2_155 ----------DLDKTE-----------------------------
Mb0521|M.bovis_AF2122/97 FDAESRRGGGDMQSSPKRSPSN-----------------------
Rv0509|M.tuberculosis_H37Rv FDAESRRGGGDMQSSPKRSPSN-----------------------
MAV_4640|M.avium_104 FDAG----------APQQ-PTE-----------------------
MLBr_02422|M.leprae_Br4923 FSDTTRYGTSPAQSSSKYHAE------------------------
MMAR_0842|M.marinum_M LDAGAGPQGADGPSAGPTPSAPNPSAE------------------
MUL_4598|M.ulcerans_Agy99 LDAGSGPQGADGPSAGPTPSAPNPSAE------------------
MAB_3993c|M.abscessus_ATCC_199 LHE------------------------------------------